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Filipa Esteves completed her Biochemistry degree in 2007, and her Master's degree in Molecular and Microbial Biology in 2013, both by the Universidade do Algarve - Faculdade de Ciências e Tecnologia. She concluded her PhD in Mechanisms of Disease and Regenerative Medicine, a joint Doctoral Programme by the Universidade do Algarve - Faculdade de Medicina e Ciências Biomédicas and the Nova Medical School from the Universidade Nova de Lisboa, in 2021. She has participated as a Researcher/Research Fellow in eight Research Projects. Her knowledge fields include bioinformatics, iPSCs, cell culture, cells differentiation, molecular biology, molecular diagnostics, molecular variability, human genetics, genetics and heredity, population genetics, immunology, epidemiology, oncology, virology, microscopy, and laboratory management.
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Identification

Personal identification

Full name
Filipa Alexandra Oleiro Esteves

Citation names

  • Esteves, Filipa
  • Esteves, F

Author identifiers

Ciência ID
B61D-969F-4DD5

Knowledge fields

  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Medical and Health Sciences - Health Sciences - Epidemiology
  • Natural sciences - Biological Sciences - Virology
  • Natural sciences - Biological Sciences - Genetics and Heredity
  • Medical and Health Sciences - Clinical Medicine - Oncology
Education
Degree Classification
2016/01/01 - 2021/12/09
Concluded
 Mechanisms of Disease and Regenerative Medicine, PhD (Doutoramento)
Universidade do Algarve, Faculdade de Medicina e Ciências Biomédicas, Portugal
"Unveiling the role of cis-regulatory variation in breast cancer aetiology" (THESIS/DISSERTATION)
2013
Concluded
 Molecular and Microbial Biology, MSc (Mestrado)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Application of molecular tools for detection of plant viruses" (THESIS/DISSERTATION)
2007
Concluded
 Biochemistry, BSc (Licenciatura)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Reavaliação da Taxonomia de Grapevine leafroll-associated virus 3 e suas Implicações no Diagnóstico do Enrolamento da Videira" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2022/01/01 - Current Researcher (Research) Algarve Biomedical Center, Portugal
2016/01/01 - 2021/12/09 Researcher (Research) Universidade do Algarve, Portugal
2020/04/01 - 2021/08/24 Researcher (Research) Algarve Biomedical Center, Portugal
2015/03/01 - 2015/08/31 Researcher (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2011/03/15 - 2014/07/21 Researcher (Research) Universidade do Algarve, Portugal
2008/06/16 - 2010/07/15 Researcher (Research) Universidade do Algarve, Portugal
2006/09/01 - 2007/09/30 Research Trainee (Research) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
Projects

Grant

Designation Funders
2016/01/01 - 2021/12/09 Unveiling the role of cis-regulatory variation in breast cancer aetiology
PD/BD/114252/2016
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2024/01/01 - Current AdvGT-CSB: Advancing the development of a gene therapy for Cockayne Syndrome type B
AdvGT-CSB: Advancing the development of a gene therapy for Cockayne Syndrome type B
Post-doc Fellow
2023/02/01 - Current ExCITinG - Exploring CITED2 role in glioblastoma stem cell biology
2022.09209.PTDC
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2023/12/31 ALFA Score - ALgarve Fit Aging Score: uma nova ferramenta integrada para melhorar a qualidade de vida e o envelhecimento saudável
ALG-01-0145-FEDER-072586
Post-doc Fellow
Algarve Biomedical Center, Portugal
 Programa Operacional Regional do Algarve - CRESC ALGARVE 2020
Concluded
2019/03/28 - 2022/05/31 INTERGEN - INnovating breast cancer GWAS through inTEgRation of functional GENomics
PTDC/MED-GEN/30895/2017
Researcher
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/04/01 - 2021/08/24 PtCAC - CRE-ABC
72682
Researcher
Algarve Biomedical Center, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Algarve
Ongoing
2020/04/01 - 2021/08/24 VISITOR (VarIants Screen In souThern pORtugal) - Monitoring Variants of Concern (VOC) in Southern Portugal
ALG-01-01D2-FEDER-000001
Researcher
Algarve Biomedical Center, Portugal
 Programa Operacional Regional do Algarve - CRESC ALGARVE 2020
Ongoing
2015/03/01 - 2015/08/31 Norovirus infection and disease in Portuguese elderly: a glimpse on epidemiology and host genetics
PTDC/DTP-EPI/1222/2012
Research Fellow
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/03/15 - 2014/07/21 VirVitis - Molecular probing for effective strategies to control Fanleaf and Leafroll in grapevine
PTDC/AGR-ALI/109859/2009
Research Fellow
Universidade do Algarve, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/06/16 - 2010/07/15 AMPELO - Molecular re-assessment of taxonomic units within Ampelovirus and its implications under the new grapevine certification scheme
PTDC/AGR-AAM/65094/2006
Research Fellow
Universidade do Algarve, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Fernandes, MT; Matos, A; Calado, SM ; Correia, CD; De Sousa-Coelho, Ana Luísa; Esteves, F; Bragança, José. "CITED2 Expression Level Impacts the Self-renewal Properties of Glioblastoma Stem Cells". Paper presented in EACR 2024 Congress: Innovative Cancer Science | EACR2024, Rotterdam, 2024.
    Published
Conference poster
  1. Fernandes, MT; Matos, A; Calado, SM ; Correia, CD; De Sousa-Coelho, Ana Luísa; Esteves, F; Bragança, José. "CITED2 Expression Level Impacts the Self-renewal Properties of Glioblastoma Stem Cells". Paper presented in EACR 2024 Congress: Innovative Cancer Science | EACR2024, 2024.
  2. Esteves, F; Calado, SM ; Fernandes, MT. "CITED2 role in Gliomas: insights from transcriptomics". Paper presented in SINAL 2024 - 11th Meeting on Signal Transduction, 2024.
Journal article
  1. Brito, D. V. C.; Esteves, F.; Rajado, A. T.; Silva, N.; Andrade, R.; Apolónio, J.; Calado, S.; et al. "Assessing cognitive decline in the aging brain: lessons from rodent and human studies". npj Aging 9 23 (2023): http://dx.doi.org/10.1038/s41514-023-00120-6.
    10.1038/s41514-023-00120-6
  2. Esteves, Filipa; Brito, David; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vânia Palma; ALFA Score Consortium; et al. "Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials". Mechanisms of Ageing and Development 214 (2023): 111854. http://dx.doi.org/10.1016/j.mad.2023.111854.
    10.1016/j.mad.2023.111854
  3. Silva, Nádia; Rajado, Ana Teresa; Esteves, Filipa; Brito, David; Apolónio, Joana; Roberto, Vânia Palma; ALFA Score Consortium; et al. "Measuring healthy ageing: current and future tools". Biogerontology (2023): http://dx.doi.org/10.1007/s10522-023-10041-2.
    10.1007/s10522-023-10041-2
  4. Correia, Cátia D.; Ferreira, Anita; Fernandes, Mónica T.; Silva, Bárbara M.; Esteves, Filipa; Leitão, Helena S.; Bragança, José; Calado, Sofia M.. "Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications - Are We on the Road to Success?". Cells 12 13 (2023): 1727. http://dx.doi.org/10.3390/cells12131727.
    10.3390/cells12131727
  5. Rajado, Ana Teresa; Silva, Nádia; Esteves, Filipa; Brito, David; Binnie, Alexandra; ALFA Score Consortium; Araújo, Inês M.; et al. "How can we modulate aging through nutrition and physical exercise? An epigenetic approach". Aging 15 8 (2023): 3191-3217. http://dx.doi.org/10.18632/aging.204668.
    10.18632/aging.204668
  6. Esteves, Filipa; Xavier, Joana M; Ford, Anthony M; Rocha, Cátia; Pharoah, Paul DP; Caldas, Carlos; Chin, Suet-Feung; Maia, Ana-Teresa. Corresponding author: Maia, Ana-Teresa. "Germline Allelic Expression of Genes at 17q22 Locus Associates with Risk of Breast Cancer". European Journal of Cancer 172 (2022): 146-157. https://doi.org/10.1016/j.ejca.2022.05.034.
    Open access • Published
  7. Correia, Lizelle; Magno, Ramiro; Xavier, Joana M.; de Almeida, Bernardo P.; Duarte, Isabel; Esteves, Filipa; Ghezzo, Marinella; et al. "Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant". npj Breast Cancer 8 1 (2022): http://dx.doi.org/10.1038/s41523-022-00435-9.
    Open access • 10.1038/s41523-022-00435-9
  8. Piedade, João; Nordgren, Johan; Esteves, Filipa; Esteves, Aida; Teodósio, Rosa; Svensson, Lennart; Istrate, Claudia. "Molecular epidemiology and host genetics of norovirus and rotavirus infections in Portuguese elderly living in aged care homes". Journal of Medical Virology 91 6 (2019): 1014-1021. http://dx.doi.org/10.1002/jmv.25425.
    Published • 10.1002/jmv.25425
  9. Fonseca, F; Esteves, Filipa; Teixeira Santos, M; Brazão, J; Eiras-Dias, JE. "Genetic variants of Grapevine leafroll-associated virus 2 infecting Portuguese grapevine cultivars". Phytopathologia Mediterranea 55 11 (2016): 73-88. https://doi.org/10.14601/Phytopathol_Mediterr-16378.
    Published • 10.14601/Phytopathol_Mediterr-16378
  10. Esteves, Filipa; Teixeira Santos, Margarida; Eiras-Dias, José Eduardo; Fonseca, Filomena. "Molecular data mining to improve antibody-based detection of Grapevine leafroll-associated virus 1 (GLRaV-1)". Journal of Virological Methods 194 1-2 (2013): 258-270. http://dx.doi.org/10.1016/j.jviromet.2013.09.004.
    10.1016/j.jviromet.2013.09.004
  11. Esteves, Filipa; Teixeira Santos, Margarida; Eiras-Dias, José Eduardo; Fonseca, Filomena. "Occurrence of grapevine leafroll-associated virus 5 in Portugal: genetic variability and population structure in field-grown grapevines". Archives of Virology 157 9 (2012): 1747-1765. http://dx.doi.org/10.1007/s00705-012-1371-2.
    10.1007/s00705-012-1371-2
Thesis / Dissertation
  1. "Unveiling the role of cis-regulatory variation in breast cancer aetiology". PhD, Universidade do Algarve, Faculdade de Medicina e Ciências Biomédicas, 2021.
  2. "Application of molecular tools for detection of plant viruses". Master, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2013.
  3. "Reavaliação da Taxonomia de Grapevine Leafroll-associated Virus 3 (GLRaV-3) e suas Implicações no Diagnóstico do Enrolamento da Videira". Degree, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2007.

Intellectual property

Provisional application for patent
  1. 2019. "Methods of analysis of polymorphisms associated with cancer and uses thereof".
    Protected