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I have a Biochemistry degree, a Master's degree in Molecular and Microbial Biology, and a PhD in Mechanisms of Disease and Regenerative Medicine. Since my undergraduate internship in 2006, I successfully contributed with my expertise to several multidisciplinary international research groups, while participating as a Researcher/Research Fellow in ten Research Projects. My work and research have contributed to advances in a variety of scientific fields, including virology, cancer, ageing, neurosciences, stem cell biology, and computational biology. From research on viruses affecting one of the most globally economically relevant crops to viruses responsible for acute gastroenteritis worldwide, I have contributed with genetic data, molecular diagnostic tools, and infection control strategies. Through my continuous work in molecular analysis and computational biology, I have also focused on developing risk assessment tools for breast cancer, which can be applied to other complex diseases. Furthermore, I have contributed to molecular testing and monitoring of variants of concern during the COVID-19 pandemic. I further contributed to ageing and neurodegeneration research in the field of stem cell biology by developing neuronal cellular models to test and identify geroprotective compounds able to delay or inhibit ageing and neurodegenerative processes. In total, I am the author/co-author of 13 articles in specialized peer-reviewed journals and presented my work nationally and internationally in congresses and meetings. I have co-supervised and mentored undergraduate, master, and doctorate students, and integrated academic juries. I am also an experienced reviewer for international journals and part of the expert teams for reviewing scientific proposals presented to international science centers.
Identification

Personal identification

Full name
Filipa Alexandra Oleiro Esteves

Citation names

  • Esteves, Filipa
  • Esteves, F

Author identifiers

Ciência ID
B61D-969F-4DD5

Knowledge fields

  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Medical and Health Sciences - Health Sciences - Epidemiology
  • Natural sciences - Biological Sciences - Virology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
Education
Degree Classification
2016/01/01 - 2021/12/09
Concluded
Mechanisms of Disease and Regenerative Medicine, PhD (Doutoramento)
Universidade do Algarve, Faculdade de Medicina e Ciências Biomédicas, Portugal
"Unveiling the role of cis-regulatory variation in breast cancer aetiology" (THESIS/DISSERTATION)
2013
Concluded
Molecular and Microbial Biology, MSc (Mestrado)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Application of molecular tools for detection of plant viruses" (THESIS/DISSERTATION)
2007
Concluded
Biochemistry, BSc (Licenciatura)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Reavaliação da Taxonomia de Grapevine leafroll-associated virus 3 e suas Implicações no Diagnóstico do Enrolamento da Videira" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution
Employer
2022/01/01 - Current Researcher (Research) Algarve Biomedical Center, Portugal
2016/01/01 - 2021/12/09 Researcher (Research) Universidade do Algarve, Portugal
2020/04/01 - 2021/08/24 Researcher (Research) Algarve Biomedical Center, Portugal
2015/03/01 - 2015/08/31 Researcher (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2011/03/15 - 2014/07/21 Researcher (Research) Universidade do Algarve, Portugal
2008/06/16 - 2010/07/15 Researcher (Research) Universidade do Algarve, Portugal
2006/09/01 - 2007/09/30 Research Trainee (Research) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
Projects

Grant

Designation Funders
2016/01/01 - 2021/12/09 Unveiling the role of cis-regulatory variation in breast cancer aetiology
PD/BD/114252/2016
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2024/01/01 - Current AdvGT-CSB: Advancing the development of a gene therapy for Cockayne Syndrome type B
AdvGT-CSB: Advancing the development of a gene therapy for Cockayne Syndrome type B
Post-doc Fellow
2023/02/01 - Current ExCITinG - Exploring CITED2 role in glioblastoma stem cell biology
2022.09209.PTDC
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2023/12/31 ALFA Score - ALgarve Fit Aging Score: uma nova ferramenta integrada para melhorar a qualidade de vida e o envelhecimento saudável
ALG-01-0145-FEDER-072586
Post-doc Fellow
Algarve Biomedical Center, Portugal
Programa Operacional Regional do Algarve - CRESC ALGARVE 2020
Concluded
2019/03/28 - 2022/05/31 INTERGEN - INnovating breast cancer GWAS through inTEgRation of functional GENomics
PTDC/MED-GEN/30895/2017
Researcher
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/04/01 - 2021/08/24 PtCAC - CRE-ABC
72682
Researcher
Algarve Biomedical Center, Portugal
Comissão de Coordenação e Desenvolvimento Regional do Algarve
Ongoing
2020/04/01 - 2021/08/24 VISITOR (VarIants Screen In souThern pORtugal) - Monitoring Variants of Concern (VOC) in Southern Portugal
ALG-01-01D2-FEDER-000001
Researcher
Algarve Biomedical Center, Portugal
Programa Operacional Regional do Algarve - CRESC ALGARVE 2020
Ongoing
2015/03/01 - 2015/08/31 Norovirus infection and disease in Portuguese elderly: a glimpse on epidemiology and host genetics
PTDC/DTP-EPI/1222/2012
Research Fellow
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/03/15 - 2014/07/21 VirVitis - Molecular probing for effective strategies to control Fanleaf and Leafroll in grapevine
PTDC/AGR-ALI/109859/2009
Research Fellow
Universidade do Algarve, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/06/16 - 2010/07/15 AMPELO - Molecular re-assessment of taxonomic units within Ampelovirus and its implications under the new grapevine certification scheme
PTDC/AGR-AAM/65094/2006
Research Fellow
Universidade do Algarve, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Fernandes, MT; Matos, A; Calado, SM ; Correia, CD; De Sousa-Coelho, Ana Luísa; Esteves, F; Bragança, José. "CITED2 Expression Level Impacts the Self-renewal Properties of Glioblastoma Stem Cells". Paper presented in EACR 2024 Congress: Innovative Cancer Science | EACR2024, Rotterdam, 2024.
    Published
Conference poster
  1. Fernandes, MT; Matos, A; Calado, SM ; Correia, CD; De Sousa-Coelho, Ana Luísa; Esteves, F; Bragança, José. "CITED2 Expression Level Impacts the Self-renewal Properties of Glioblastoma Stem Cells". Paper presented in EACR 2024 Congress: Innovative Cancer Science | EACR2024, 2024.
  2. Esteves, F; Calado, SM ; Fernandes, MT. "CITED2 role in Gliomas: insights from transcriptomics". Paper presented in SINAL 2024 - 11th Meeting on Signal Transduction, 2024.
Journal article
  1. Esteves, Filipa; Brito, David; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vânia Palma; Andrade, Raquel P.; et al. "Establishment of an induced pluripotent cell line (ABCRIi001-A) from an elderly female for ageing research". Stem Cell Research 81 (2024): 103576. http://dx.doi.org/10.1016/j.scr.2024.103576.
    Published • 10.1016/j.scr.2024.103576
  2. Santos, Daniela F.; Simão, Sónia; Nóbrega, Clévio; Bragança, José; Castelo-Branco, Pedro; Araújo, Inês M.; Andrade, Raquel P.; et al. "Oxidative stress and aging: synergies for age related diseases". FEBS Letters (2024): http://dx.doi.org/10.1002/1873-3468.14995.
    10.1002/1873-3468.14995
  3. Brito, D. V. C.; Esteves, F.; Rajado, A. T.; Silva, N.; Andrade, R.; Apolónio, J.; Calado, S.; et al. "Assessing cognitive decline in the aging brain: lessons from rodent and human studies". npj Aging 9 23 (2023): http://dx.doi.org/10.1038/s41514-023-00120-6.
    10.1038/s41514-023-00120-6
  4. Esteves, Filipa; Brito, David; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vânia Palma; ALFA Score Consortium; et al. "Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials". Mechanisms of Ageing and Development 214 (2023): 111854. http://dx.doi.org/10.1016/j.mad.2023.111854.
    10.1016/j.mad.2023.111854
  5. Silva, Nádia; Rajado, Ana Teresa; Esteves, Filipa; Brito, David; Apolónio, Joana; Roberto, Vânia Palma; ALFA Score Consortium; et al. "Measuring healthy ageing: current and future tools". Biogerontology (2023): http://dx.doi.org/10.1007/s10522-023-10041-2.
    10.1007/s10522-023-10041-2
  6. Correia, Cátia D.; Ferreira, Anita; Fernandes, Mónica T.; Silva, Bárbara M.; Esteves, Filipa; Leitão, Helena S.; Bragança, José; Calado, Sofia M.. "Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications - Are We on the Road to Success?". Cells 12 13 (2023): 1727. http://dx.doi.org/10.3390/cells12131727.
    10.3390/cells12131727
  7. Rajado, Ana Teresa; Silva, Nádia; Esteves, Filipa; Brito, David; Binnie, Alexandra; ALFA Score Consortium; Araújo, Inês M.; et al. "How can we modulate aging through nutrition and physical exercise? An epigenetic approach". Aging 15 8 (2023): 3191-3217. http://dx.doi.org/10.18632/aging.204668.
    10.18632/aging.204668
  8. Esteves, Filipa; Xavier, Joana M; Ford, Anthony M; Rocha, Cátia; Pharoah, Paul DP; Caldas, Carlos; Chin, Suet-Feung; Maia, Ana-Teresa. Corresponding author: Maia, Ana-Teresa. "Germline Allelic Expression of Genes at 17q22 Locus Associates with Risk of Breast Cancer". European Journal of Cancer 172 (2022): 146-157. https://doi.org/10.1016/j.ejca.2022.05.034.
    Open access • Published
  9. Correia, Lizelle; Magno, Ramiro; Xavier, Joana M.; de Almeida, Bernardo P.; Duarte, Isabel; Esteves, Filipa; Ghezzo, Marinella; et al. "Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant". npj Breast Cancer 8 1 (2022): http://dx.doi.org/10.1038/s41523-022-00435-9.
    Open access • 10.1038/s41523-022-00435-9
  10. Piedade, João; Nordgren, Johan; Esteves, Filipa; Esteves, Aida; Teodósio, Rosa; Svensson, Lennart; Istrate, Claudia. "Molecular epidemiology and host genetics of norovirus and rotavirus infections in Portuguese elderly living in aged care homes". Journal of Medical Virology 91 6 (2019): 1014-1021. http://dx.doi.org/10.1002/jmv.25425.
    Published • 10.1002/jmv.25425
  11. Fonseca, F; Esteves, Filipa; Teixeira Santos, M; Brazão, J; Eiras-Dias, JE. "Genetic variants of Grapevine leafroll-associated virus 2 infecting Portuguese grapevine cultivars". Phytopathologia Mediterranea 55 11 (2016): 73-88. https://doi.org/10.14601/Phytopathol_Mediterr-16378.
    Published • 10.14601/Phytopathol_Mediterr-16378
  12. Esteves, Filipa; Teixeira Santos, Margarida; Eiras-Dias, José Eduardo; Fonseca, Filomena. "Molecular data mining to improve antibody-based detection of Grapevine leafroll-associated virus 1 (GLRaV-1)". Journal of Virological Methods 194 1-2 (2013): 258-270. http://dx.doi.org/10.1016/j.jviromet.2013.09.004.
    10.1016/j.jviromet.2013.09.004
  13. Esteves, Filipa; Teixeira Santos, Margarida; Eiras-Dias, José Eduardo; Fonseca, Filomena. "Occurrence of grapevine leafroll-associated virus 5 in Portugal: genetic variability and population structure in field-grown grapevines". Archives of Virology 157 9 (2012): 1747-1765. http://dx.doi.org/10.1007/s00705-012-1371-2.
    10.1007/s00705-012-1371-2
Thesis / Dissertation
  1. "Unveiling the role of cis-regulatory variation in breast cancer aetiology". PhD, Universidade do Algarve, Faculdade de Medicina e Ciências Biomédicas, 2021.
  2. "Application of molecular tools for detection of plant viruses". Master, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2013.
  3. "Reavaliação da Taxonomia de Grapevine Leafroll-associated Virus 3 (GLRaV-3) e suas Implicações no Diagnóstico do Enrolamento da Videira". Degree, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2007.

Intellectual property

Provisional application for patent
  1. 2019. "Methods of analysis of polymorphisms associated with cancer and uses thereof".
    Protected