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Maria Cristina Moreira Romariz e Barosa de Oliveira. Completed the Doutoramento in N/A in 2012/01/10 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia and Licenciatura in Biochemistry in 1988/12/03 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia. Is Contracted Researcher in Fundação para a Ciência e a Tecnologia. Published 24 articles in journals. Co-supervised 1 MSc dissertation(s). Co-supervised 1 work(s) of course completion of LSc/BSc. Participates and/or participated as Pos-doctoral Fellow in 2 project(s), Research Fellow in 1 project(s), Research Technician Fellow in 3 project(s) and Scientific Initiation Fellow in 2 project(s). Works in the area(s) of Exact Sciences with emphasis on Chemical Sciences with emphasis on Organic Chemistry, Medical and Health Sciences with emphasis on Clinical Medicine with emphasis on Endocrinology and Metabolism and Natural sciences with emphasis on Biological Sciences with emphasis on Biochemistry. In their professional activities interacted with 93 collaborator(s) co-authorship of scientific papers. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Health Sciences - Metabolism and Nutrition; Chemistry and Biochemistry; .
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Identification

Personal identification

Full name
Maria Cristina Moreira Romariz e Barosa de Oliveira

Citation names

  • Barosa, C.

Author identifiers

Ciência ID
B61F-02F9-0F6E
ORCID iD
0000-0001-7819-2434
Researcher Id
A-6377-2014

Addresses

  • Centro de Neurociências e Biologia Celular. UC-Biotech- Biocant - Technology Transfer Association | Biocant Park |Núcleo 04 Lote 3 , 3060-197, Cantanhede, Cantanhede, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Medical and Health Sciences - Clinical Medicine - Endocrinology and Metabolism
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
French Beginner (A1) Intermediate (B1) Beginner (A1) Elementary (A2)
English Intermediate (B1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Advanced (C1) Advanced (C1)
Education
Degree Classification
2007/10/01 - 2012/01/10
Concluded
 Biochemistry (Doutoramento)
Major in Tecnologia Bioquímica
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
""Noninvasive measurements of human hepatic metabolism using deuterated water : influence of deuterium exchange processes on metabolic flux " (THESIS/DISSERTATION)
 Louvor e Distinção
2010/04/19 - 2010/04/30
Attended
 Laboratory Animal Science Course (Outros)
CNC.IBILI, Portugal
 Aprovada
1990/08/01 - 1990/08/14
Attended
 Curso Interdisciplinar Avançado em Biologia – Toxicologia Molecular Factores de Risco – no Centro de Citologia Experimental (INIC) da Universidade do Porto (Outros)
Major in Toxicologia
Universidade do Porto Faculdade de Ciências, Portugal
 B
1988/12/03
Concluded
 Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Characterization of Glycolipids isolated form Thermophilic Bacteria by NMR" (THESIS/DISSERTATION)
 12 valores
Affiliation

Science

Category
Host institution 		Employer
2019/01/15 - Current Contracted Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2015/01/15 - 2019/01/14 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
2013 - 2015 Researcher (Research) CNC.IBILI, Portugal
CNC.IBILI, Portugal
2012 - 2013 Researcher (Research) CNC.IBILI, Portugal
CNC.IBILI, Portugal
2012 - 2012 Researcher (Research) CNC.IBILI, Portugal
CNC.IBILI, Portugal
2010 - 2011 Researcher (Research) CNC.IBILI, Portugal
CNC.IBILI, Portugal
2007 - 2010 Researcher (Research) CNC.IBILI, Portugal
CNC.IBILI, Portugal
2005 - 2007 Researcher (Research) CNC.IBILI, Portugal
CNC.IBILI, Portugal
2004 - 2005 Researcher (Research) CNC.IBILI, Portugal
CNC.IBILI, Portugal

Others

Category
Host institution 		Employer
1992/01/15 - 1997/10/10 Técnica Superior de Análises Clínicas Laboratório de Análises Clínicas Cruz de Celas, Portugal
1991/03/01 - 1992/01/14 Técnica Superior de Análises Clínicas Laboratório de Análises Clínicas Sourelab, Portugal
1989 - 1990 Estagiária Laboratório de Análises Clinicas Drª Teresa Malheiro, Portugal
Outputs

Publications

Book chapter
  1. Barosa, Cristina; Jones, John G.. "Chapter 8. Recent Developments in the use of Stable Isotope Carbohydrate Tracers for the Study of Human Health". In Carbohydrate Chemistry, 208-226. Royal Society of Chemistry, 2012.
    Published • 10.1039/9781849732765-00208
Journal article
  1. Ivan Viegas; Giada Di Nunzio; Getachew Debas Belew; Torres AN; João Gabriel Silva; Perpétuo L; Barosa C; Tavares L C; John Jones. "Integration of Liver Glycogen and Triglyceride NMR Isotopomer Analyses Provides a Comprehensive Coverage of Hepatic Glucose and Fructose Metabolism.". Metabolites (2022): https://europepmc.org/articles/PMC9698123.
    10.3390/metabo12111142
  2. Margarida Coelho; Rohit Mahar; Getachew D. Belew; Alejandra Torres; Cristina Barosa; Fernando Cabral; Ivan Viegas; et al. "Enrichment of hepatic glycogen and plasma glucose from H2 18 O informs gluconeogenic and indirect pathway fluxes in naturally feeding mice". NMR in Biomedicine (2022): https://doi.org/10.1002/nbm.4837.
    10.1002/nbm.4837
  3. Laurenti, Marcello C; Dalla Man, Chiara; Varghese, Ron T; Andrews, James C; Jones, John G; Barosa, Cristina; Rizza, Robert A; et al. "Insulin Pulse Characteristics and Insulin Action in Non-Diabetic Humans". The Journal of Clinical Endocrinology & Metabolism (2021): http://dx.doi.org/10.1210/clinem/dgab100.
    In press • 10.1210/clinem/dgab100
  4. Barosa, Cristina; Ribeiro, Rogério T.; Andrade, Rita; Raposo, João F.; Jones, John G.. "Effects of Meal Fructose/Glucose Composition on Postprandial Glucose Appearance and Hepatic Glycogen Synthesis in Healthy Subjects". Journal of Clinical Medicine 10 4 (2021): 596. http://dx.doi.org/10.3390/jcm10040596.
    Accepted • 10.3390/jcm10040596
  5. Margarida Coelho; Cristina Barosa; Ludgero Tavares; John G. Jones. "Metabolic incorporation of H 2 18 O into specific glucose-6-phosphate oxygens by red-blood-cell lysates as observed by 13 C isotope-shifted NMR signals". NMR in Biomedicine (2020): https://doi.org/10.1002/nbm.4395.
    10.1002/nbm.4395
  6. DiNunzio, Giada; Belew, Getachew D.; Torres, Alejandra N.; Silva, João Gabriel; Silva, Luis P.; Barosa, Cristina; Tavares, Ludgero; Jones, John G.. "Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-69820-3.
    10.1038/s41598-020-69820-3
  7. Theresia Sarabhai; Sabine Kahl; Julia Szendroedi; Daniel F. Markgraf; Oana-Patricia Zaharia; Cristina Barosa; Christian Herder; et al. "Monounsaturated fat rapidly induces hepatic gluconeogenesis and whole-body insulin resistance". JCI Insight 5 10 (2020): https://doi.org/10.1172/jci.insight.134520.
    10.1172/jci.insight.134520
  8. Barosa, C.; Shanmugam, H.; Cabral, F.; Jones, J.G.. "p-Aminobenzoic acid as an alternative chemical biopsy agent for human hepatic UDP-glucose". Analytical Biochemistry (2020): http://dx.doi.org/10.1016/j.ab.2019.113511.
    10.1016/j.ab.2019.113511
  9. Jarak, I.; Barosa, C.; Martins, F.O.; Silva, J.C.P.; Santos, C.; Belew, G.D.; Rito, J.; et al. "Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate". Magnetic Resonance in Medicine 81 1 (2019): 639-644. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051198810&partnerID=MN8TOARS.
    10.1002/mrm.27378
  10. Hernández, E.A.; Kahl, S.; Seelig, A.; Begovatz, P.; Irmler, M.; Kupriyanova, Y.; Nowotny, B.; et al. "Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance". Journal of Clinical Investigation 127 2 (2017): 695-708. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014086154&partnerID=MN8TOARS.
    10.1172/JCI89444
  11. Coelho, M.; Valente-Silva, P.; Tylki-Szymanska, A.; Henriques, T.; Barosa, C.; Carvalho, F.; Jones, J.G.. "Demonstration of glucose-6-phosphate hydrogen 5 enrichment from deuterated water by transaldolase-mediated exchange alone". Magnetic Resonance in Medicine 75 4 (2016): 1781-1786. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929832530&partnerID=MN8TOARS.
    10.1002/mrm.25749
  12. Varghese, R.T.; Man, C.D.; Sharma, A.; Viegas, I.; Barosa, C.; Marques, C.; Shah, M.; et al. "Mechanisms underlying the pathogenesis of isolated impaired glucose tolerance in humans". Journal of Clinical Endocrinology and Metabolism 101 12 (2016): 4816-4824. http://www.scopus.com/inward/record.url?eid=2-s2.0-85003545634&partnerID=MN8TOARS.
    10.1210/jc.2016-1998
  13. Varghese, R.T.; Viegas, I.; Barosa, C.; Marques, C.; Shah, M.; Rizza, R.A.; Jones, J.G.; Vella, A.. "Diabetes-associated variation in TCF7L2 is not associated with hepatic or extrahepatic insulin resistance". Diabetes 65 4 (2016): 887-892. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962160951&partnerID=MN8TOARS.
    10.2337/db15-1593
  14. Jones, J.G.; Kahl, S.; Carvalho, F.; Barosa, C.; Roden, M.. "Simplified analysis of acetaminophen glucuronide for quantifying gluconeogenesis and glycogenolysis using deuterated water". Analytical Biochemistry (2015): http://www.scopus.com/record/display.url?eid=2-s2.0-84927713909&origin=inward&txGid=6A3F3CA7BCA19FE70C8A1465E4C2B54D.zQKnzAySRvJOZYcdfIziQ%3a15.
    10.1016/j.ab.2015.03.018
  15. Barosa, C.; Jones, J.G.; Rizza, R.; Basu, A.; Basu, R.. "Acetaminophen glucuronide and plasma glucose report identical estimates of gluconeogenesis and glycogenolysis for healthy and prediabetic subjects using the deuterated water method". Magnetic Resonance in Medicine 70 2 (2013): 315-319. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881130089&partnerID=MN8TOARS.
    10.1002/mrm.24485
  16. Basu, R.; Barosa, C.; Jones, J.; Dube, S.; Carter, R.; Basu, A.; Rizza, R.A.. "Pathogenesis of prediabetes: Role of the liver in isolated fasting hyperglycemia and combined fasting and postprandial hyperglycemia". Journal of Clinical Endocrinology and Metabolism 98 3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874826222&partnerID=MN8TOARS.
    10.1210/jc.2012-3056
  17. Barosa, C.; Silva, C.; Fagulha, A.; Barros, L.; Caldeira, M.M.; Carvalheiro, M.; Jones, J.G.. "Sources of hepatic glycogen synthesis following a milk-containing breakfast meal in healthy subjects". Metabolism: Clinical and Experimental 61 2 (2012): 250-254. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856105554&partnerID=MN8TOARS.
    10.1016/j.metabol.2011.06.022
  18. Delgado, T.C.; Barosa, C.; Nunes, P.M.; Cerdán, S.; Geraldes, C.F.G.C.; Jones, J.G.. "Resolving the sources of plasma glucose excursions following a glucose tolerance test in the rat with deuterated water and [u- 13c]glucose". PLoS ONE 7 3 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859129416&partnerID=MN8TOARS.
    10.1371/journal.pone.0034042
  19. Delgado, T.C.; Barosa, C.; Nunes, P.M.; Scott, D.K.; O'Doherty, R.M.; Cerdán, S.; Geraldes, C.F.; Jones, J.G.. "Effect of cyclosporine A on hepatic carbohydrate metabolism and hepatic gene expression in rat". Expert Opinion on Drug Metabolism and Toxicology 8 10 (2012): 1223-1230. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866515605&partnerID=MN8TOARS.
    10.1517/17425255.2012.709500
  20. Basu, R.; Barosa, C.; Basu, A.; Pattan, V.; Saad, A.; Jones, J.; Rizza, R.. "Transaldolase exchange and its effects on measurements of gluconeogenesis in humans". American Journal of Physiology - Endocrinology and Metabolism 300 2 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79251576452&partnerID=MN8TOARS.
    10.1152/ajpendo.00403.2010
  21. Kacerovsky, M.; Jones, J.; Schmid, A.I.; Barosa, C.; Lettner, A.; Kacerovsky-Bielesz, G.; Szendroedi, J.; et al. "Postprandial and fasting hepatic glucose fluxes in long-standing type 1 diabetes". Diabetes 60 6 (2011): 1752-1758. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959442449&partnerID=MN8TOARS.
    10.2337/db10-1001
  22. Barosa, C.; Almeida, M.; Caldeira, M.M.; Gomes, F.; Jones, J.G.. "Contribution of proteolytic and metabolic sources to hepatic glutamine by 2H NMR analysis of urinary phenylacetylglutamine 2H-enrichment from 2H2O". Metabolic Engineering 12 1 (2010): 53-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449718782&partnerID=MN8TOARS.
    10.1016/j.ymben.2009.08.009
  23. Jones, J.G.; Garcia, P.; Barosa, C.; Delgado, T.C.; Diogo, L.. "Hepatic anaplerotic outflow fluxes are redirected from gluconeogenesis to lactate synthesis in patients with Type 1a glycogen storage disease". Metabolic Engineering 11 3 (2009): 155-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-63949084742&partnerID=MN8TOARS.
    10.1016/j.ymben.2009.01.003
  24. Jones, J.G.; Garcia, P.; Barosa, C.; Delgado, T.C.; Caldeira, M.M.; Diogo, L.. "Quantification of hepatic transaldolase exchange activity and its effects on tracer measurements of indirect pathway flux in humans". Magnetic Resonance in Medicine 59 2 (2008): 423-429. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949195682&partnerID=MN8TOARS.
    10.1002/mrm.21451
  25. Delgado, T.C.; Barosa, C.; Castro, M.M.C.A.; Geraldes, C.F.G.C.; Bastos, M.; Baptista, C.; Fagulha, A.; et al. "Sources of hepatic glucose production by 2H2O ingestion and Bayesian analysis of 2H glucuronide enrichment". Magnetic Resonance in Medicine 60 3 (2008): 517-523. http://www.scopus.com/inward/record.url?eid=2-s2.0-51449093986&partnerID=MN8TOARS.
    10.1002/mrm.21681
  26. Duarte, I.F.; Goodfellow, B.J.; Barros, A.; Jones, J.G.; Barosa, C.; Diogo, L.; Garcia, P.; Gil, A.M.. "Metabolic characterisation of plasma in juveniles with glycogen storage disease type 1a (GSD1a) by high-resolution 1H NMR spectroscopy". NMR in Biomedicine 20 4 (2007): 401-412. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249731949&partnerID=MN8TOARS.
    10.1002/nbm.1073
  27. Sena, C.M.; Barosa, C.; Nunes, E.; Seiça, R.; Jones, J.G.. "Sources of endogenous glucose production in the Goto-Kakizaki diabetic rat". Diabetes and Metabolism 33 4 (2007): 296-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548695455&partnerID=MN8TOARS.
    10.1016/j.diabet.2007.03.002
  28. Jones, J.; Barosa, C.; Gomes, F.; Carina Mendes, A.; Delgado, T.; Diogo, L.; Garcia, P.; et al. "NMR Derivatives for quantification of 2H and 13C-enrichment of human glucuronide from metabolic tracers". Journal of Carbohydrate Chemistry 25 2-3 (2006): 203-217. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745133402&partnerID=MN8TOARS.
    10.1080/07328300600732840
  29. Jones, J.G.; Fagulha, A.; Barosa, C.; Bastos, M.; Barros, L.; Baptista, C.; Caldeira, M.M.; Carvalheiro, M.. "Noninvasive analysis of hepatic glycogen kinetics before and after breakfast with deuterated water and acetaminophen". Diabetes 55 8 (2006): 2294-2300. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749326344&partnerID=MN8TOARS.
    10.2337/db06-0304
  30. Mendes, A.C.; Caldeira, M.M.; Silva, C.; Burgess, S.C.; Merritt, M.E.; Gomes, F.; Barosa, C.; et al. "Hepatic UDP-glucose 13C isotopomers from [U-13C] glucose: A simple analysis by 13C NMR of urinary menthol glucuronide". Magnetic Resonance in Medicine 56 5 (2006): 1121-1125. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750619915&partnerID=MN8TOARS.
    10.1002/mrm.21057
  31. Ribeiro, A.; Caldeira, M.M.; Carvalheiro, M.; Bastos, M.; Baptista, C.; Fagulha, A.; Barros, L.; Barosa, C.; Jones, J.G.. "Simple measurement of gluconeogenesis by direct 2H NMR analysis of menthol glucuronide enrichment from 2H2O". Magnetic Resonance in Medicine 54 2 (2005): 429-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-22744445555&partnerID=MN8TOARS.
    10.1002/mrm.20567
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2012/03/09 “Paracetamol Glucuronide And Plasma Glucose Report Identical 2H-Enrichments From Deuterated Water For Healthy And Pre-Diabetic Subjects” 10º Congresso Português Diabetes, Vilamoura¿, Portugal, 7-10 Março de 2012
Sociedade Portuguesa de Diabetes (Vilamoura, Portugal)
2010/06/27 “Significant Transaldolase Exchange Activity in Human Liver: implications for tracer measurements of gluconeogenesis” American Diabetes Association 70th Scientific Sessions, Orlando, FL., USA, June 25-29, 2010
American Diabetes Association (ADA) (Orlando, United States)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020 - Current Developing 18O water (H218O) as a tracer to quantify fat metabolism
Supervisor
Center for Neurosciences and Cell Metabolism- University of Coimbra, Portugal
2021/02/15 - 2021/11/04 Glycogen isolation from mesenteric adipose tissue obtained from mice under high sugar diet and after anti diabetic treatment. Developing a method for tracer MS analysis
Supervisor
 Biochemistry (Degree)
Center for Neurosciences and Cell Metabolism- University of Coimbra, Portugal
2020/09/08 - 2020/10/12 Determinação da lipogénese de novo em murganhos previamente submetidos a uma dieta com elevado teor de açúcares e tratados com um antidiabético oral
Supervisor
 Biochemistry (Scientific initiation)
Center for Neurosciences and Cell Metabolism- University of Coimbra, Portugal
2020 - 2020 Synthesis and 1H and 13C NMR assignments of a, ß-D-glucose pentaacetate
Supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 - 2020 Metabolic Study Using Acetaminophen and Isotope Labeling 13C and 2H
Co-supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/03 - 2019/07 Isolation and purification of urinary N-acetylbenzoylglucuronate, a product of hepatic biotransformation of p-aminobenzoic acid: its application in noninvasive sampling of glucose metabolism intermediates in humans
Co-supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Association member

Society Organization name Role
2008 - Current Portuguese Society of Diabetology
2008 - Current Portuguese Society of Diabetology
Distinctions

Award

2020 Poster-Oral
European Society for Clinical Investigation, Netherlands