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Identification

Personal identification

Full name
Paulo César Silva Pinheiro

Author identifiers

Ciência ID
B712-04A4-B409

Websites

Education
Degree Classification
2019
Concluded
 Modular Training in Laboratory Animal Science (small rodents) (Outros)
CNC.IBILI, Portugal
 Module A, 17.7/20; Module B, 19.3/20
2001/10/01 - 2006/01/19
Concluded
 PhD in Biology (Doutoramento)
Major in Cell Biology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Presynaptic kainate receptors in the hippocampus: a critical role for GluR7 at the mossy fiber synapse" (THESIS/DISSERTATION)
 Magna cum laude
2001
Concluded
 Biologia Aplicada (Applied Biology) (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"Organotypic Slice Cultures as a Model to Research Presynaptic Kainate Receptors and Excitotoxicity" (THESIS/DISSERTATION)
 16/20 (very good)
Affiliation

Science

Category
Host institution 		Employer
2022/10/01 - 2023/01/31 Principal Investigator (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/07/01 - 2022/09/30 Auxiliary Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/01/01 - 2020/06/30 Contracted Researcher (Research) Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2013/10/01 - 2018/09/30 Auxiliary Researcher (Research) CNC.IBILI, Portugal
2009/05/01 - 2014/12/31 Postdoc (Research) Københavns Universitet Det Natur- og Biovidenskabelige Fakultet, Denmark
Kobenhavns Universitet Panum Instituttet, Denmark
2008/04/01 - 2009/03/31 Contracted Researcher (Research) Centre National de la Recherche Scientifique, France
Neurocentre Magendie, France
2006/04/01 - 2008/03/31 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Neurocentre Magendie, France
(...)
2001/10/01 - 2006/01/19 Research Trainee (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2023/02/01 - Current Assistant Professor (University Teacher) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2017/09/01 - 2023/01/31 Invited Assistant Professor (University Teacher) Escola Universitária Vasco da Gama, Portugal

Others

Category
Host institution 		Employer
2011/01 - 2012/12 Marie Curie Fellow Københavns Universitet Det Natur- og Biovidenskabelige Fakultet, Denmark
Kobenhavns Universitet Panum Instituttet, Denmark
Projects

Grant

Designation Funders
2004 - Current Zinc excitotoxicity in organotypic hippocampal slice cultures
Calouste Gulbenkian short-term fellowship
PhD Student Fellow
Biologisk Institut Syddansk Universitet, Denmark
Concluded
2016 - 2016 IBRO/FENS travel grant
N/A
813986
 International Brain Research Organization
2012 - 2013 Role of Doc2 in vesicle fusion and transmitter release
n/a
Principal investigator
Kobenhavns Universitet Panum Instituttet, Denmark
 Københavns Universitet
Concluded
2006/05/01 - 2008/04/30 Role of mossy fiber synapse kainate receptors in synaptic transmission and plasticity
SFRH/BPD/23314/2005
Post-doc Fellow
Institut Interdisciplinaire de Neurosciences, France
 Fundação para a Ciência e a Tecnologia
Concluded
2001/10/01 - 2006/01/19 Presynaptic kainate receptors in the hippocampus: Essential role for the glur7 subunit at mossy fiber synapses in the hippocampus
SFRH/BD/5319/2001
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2000/10 - 2001/09 12 months Grant for Initiation to Scientific Research
n/a
Integration into Research Grant Fellow
Concluded

Contract

Designation Funders
2021/01/01 - Current Synaptic vesicle maturation and its relevance for neurodegeneration
PTDC/MED-NEU/8030/2020
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/09/26 - Current Syn2Psy - Synaptic Dysfunction in Neuropsychiatric Disorders
info:eu-repo/grantAgreement/EC/H2020/813986/EU
Principal investigator
CNC.IBILI, Portugal
 EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
Ongoing
2024/01/01 - 2026/12/31 CROSS_3DTOOL_4ALS
CROSS_3DTOOL_4ALS
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidad de Salamanca Facultad de Medicina, Spain
Comissão de Coordenação e Desenvolvimento Regional do Centro
Ongoing
2023 - 2026 Homeostatic plasticity defects in autism: insight from human mutations in the CNTNAP2 gene
n/a
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundació la Marató de TV3
Ongoing
2022/01/15 - 2025/01/14 Human Neuronal Cells Differentiated from Urine-derived Stem Cells as a Platform for Personalized Medicine in Amyotrophic Lateral Sclerosis
PTDC/BTM-ORG/0055/2021
Researcher
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2025 MicroRNAs And Cognition in Longcovid: Exploratory Study (MIRACLES)
2022.04018.PTDC
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/12/01 - 2024/11/30 Regulation of prefrontal cortical synaptic function and behaviour by chronic stress-induced miRNA-186-5p
HR21-01077
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Obra Social La Caixa
Ongoing
2021/01/01 - 2023/12/31 mStar - Potassium channel dysfunction in models of neurodevelopmental disorders
HR20-00904
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Obra Social La Caixa
Ongoing
2018/10 - 2021/09 Alternate SNAPs in neurotransmitter release: from molecular function to neurocognitive dysfunction
PTDC/BIA-CEL/29451/2017
Principal investigator
CNC.IBILI, Portugal
 Foundation for Science and Technology (Lisbon)
Ongoing
2018/07/01 - 2021/06/30 COGNITIVE DISORDERS AS DEFECTS IN SYNAPTIC FUNCTION: INSIGHT FROM HUMAN MUTATIONS IN THE CACNG2 GENE
PTDC/MED-NEU/28541/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2020 BrainHealth 2020: Deteção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias
CENTRO-01-0145-FEDER-000008
Supervisor
Universidade de Coimbra, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro

European Commission
Ongoing
2013/10 - 2018/09 Role of distinct synaptotagmin isoforms in exocytosys and neuronal function
IF/01302/2012
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2014 - 2017 A role for Contactin-associated proteins 1 and 2 in experience-dependent plasticity
PTDC/NEU-NMC/4888/2014
Researcher
Fundação para a Ciência e a Tecnologia
2010/07 - 2014/12 synSys - Synaptic Systems: dissecting brain function in health and disease
H-2009-242167
 European Commission
2010/01 - 2014/12 Synaptotagmin isoformer og deres funktion i neurotransmitter-frisættelsen
R34-A3740
Principal investigator
Københavns Universitet, Denmark
 Lundbeckfonden
Concluded
2011 - 2012 Marie Curie Fellowship - Exosyts
PIEF-GA-2009-254647
Principal investigator
Københavns Universitet, Denmark
 European Commission
Concluded
2007/05/01 - 2010/04/30 Células estaminais da região subventricular na reparação cerebral em epilepsia do lobo temporal
PTDC/SAU-NEU/68465/2006
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/12 - 2009/12 From molecules to networks: understanding synaptic physiology and pathology of the brain through mouse models
LSH-2004-019055
 European Commission
2007 - 2009 Le zinc synaptique : un modulateur endogène de la neurotransmission excitatrice?
ANR-07-NEUR-0044
Researcher
Centre National de la Recherche Scientifique, France
 Agence nationale de la recherche
Concluded
2005 - 2007 Récepteurs kaïnate présynaptiques: fonctions, mécanismes et trafic polarizé
ANR-05-NEUR-0033
Researcher
Agence nationale de la recherche
2002 - 2005 Immunological and functional identification of ionotropic presynaptic glutamate receptors
FCB/46804/2002
 Fundação para a Ciência e a Tecnologia
2002 - 2005 Neuroprotective effect of NPY in excitotoxicity and temporal lobe epilepsy
POCTI/NSE/46848/2002
Researcher
Fundação para a Ciência e a Tecnologia
1999 - 2002 Mechanisms of presynaptic kainate receptor inhibition of glutamate and GABA release: role in epileptogenesis
POCTI/1999/BCI/36491
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference abstract
  1. Pinheiro, PS. "ARHGAP8 Regulates Excitatory Synapse Function". 2018.
  2. Pinheiro, PS. "Formin-2 links neuropsychiatric phenotypes at young age to an increased risk for dementia". 2018.
  3. Pinheiro, PS. "MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons". 2018.
    10.1073/pnas.1900338116
  4. Pinheiro, PS. "Doc2b Is a Dual-Action Upstream Calcium Sensor For Vesicle Priming Interacting With Munc13 And Snares". 2016.
  5. Pinheiro, PS. "Role Of Syntaxin-1 Clustering In Regulation Of Ca2+ Channel Activity And Neurotransmitter Release". 2016.
  6. Pinheiro, PS. "The implication of Doc2b in vesicle fusion and exocytosis in mouse chromaffin cells". 2012.
  7. Pinheiro, PS. "Postsynaptic kainate receptors are not involved in presynaptic facilitation at hippocampal mossy fiber synapses". 2009.
  8. Pinheiro, Paulo. "Mechanisms for the Facilitation of Mossy Fiber Synaptic Transmission by Presynaptic Kainate Receptors". 2007.
  9. Pinheiro, PS. "Role of GluR7-containing presynaptic kainate receptors in the control of mossy fiber synaptic plasticity". 2007.
  10. Pinheiro, PS. "Functional role of GluR7 kainate receptors at the mossy fiber synapse in hippocampal CA3 pyramidal cells". 2005.
  11. Pinheiro, PS. "Activation of neuropeptide Y1 or Y2 receptors can prevent the excitotoxicity induced by kainate in rat organotypic hippocampal slice cultures". 2005.
  12. Pinheiro, PS. "Excitotoxic neurodegeneration is accompanied by activation of calpains but not of caspases in the hippocampus of epileptic rats". 2005.
  13. Pinheiro, Paulo. "Kainate receptors are localized within the active zone of hippocampal synapses". 2004.
  14. Pinheiro, Paulo. "Up-regulation of neuropeptide Y2 receptors and neuropetide Y levels following kainate injection in rats". 2004.
  15. Pinheiro, Paulo. "Proteolytic Events and Cell Death in Rat Hippocampus Following Status Epilepticus: Involvement of Calpains". 2004.
  16. Pinheiro, Paulo. "Role of presynaptic kainate receptors in the control of neurotransmitter release and neurotoxicity". 2004.
  17. Pinheiro, PS. "Calpain-mediated proteolysis in the epileptic hippocampus and neurodegenerative events". 2004.
  18. Pinheiro, Paulo. "Sub-synaptic Distribution of Kainate Receptor Subunits in the Rat Hippocampus". 2003.
  19. Pinheiro, Paulo. "Different subsynaptic distribution of adenosine receptors in CNS synapses". 2003.
  20. Pinheiro, Paulo. "AMPA and Kainate Receptors as Key Mediators of Zinc Neurotoxicity in Organotypic Cultures of the Rat Hippocampus". 2002.
  21. Pinheiro, Paulo. "Identification of presynaptic AMPA receptors in the rat hippocampus". 2002.
  22. Pinheiro, Paulo. "Mechanisms involved in the modulation of basal and evoked release of glutamate by kainate receptors". 2001.
Conference poster
  1. Beatriz; Pinheiro, PS. "miRNA-186-5p modulates the synaptic dysfunction induced by repeated stress exposure". Paper presented in BEB day 2022 - PDBEB symposium, 2022.
  2. Pinheiro, PS; Tomé, Diogo; Almeida, Ramiro D. "Regenerative and synaptogenic effect of human umbilical cord perivascular cells’ secretome in central nervous system neurons". Paper presented in 8th European Synapse Meeting, 2022.
  3. Carvalhais, Lia G; Milosevic, Ira; Ana Luísa Carvalho; Pinheiro, PS. "New insights into the roles of SNAP-29 in neuronal and synaptic functions". Paper presented in 8th European Synapse Meeting, 2022.
  4. Schmidt, J; Ana Luísa Carvalho; Pinheiro, PS. Corresponding author: Ana Luísa Carvalho. "Regulation of Glutamatergic Synapses by the Rho GTPase Activating Protein ARHGAP8". Paper presented in 8th European Synapse Meeting, 2022.
    Editor
  5. Pinheiro, PS; Carvalhais, Lia G; Carvalho, Mario; Costa, Jéssica. Corresponding author: Pinheiro, PS. "SNAP-29 influences mammalian neuronal development, glutamatergic synapse function and cognitive behavior". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  6. Pinheiro, PS; Martins L. "Synaptogenic effect of human umbilical cord perivascular cells secretome in central nervous system neurons". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  7. Pinheiro, PS; Carvalhais, Li G; Carvalho, Mario; Costa, Jéssica. Corresponding author: Pinheiro, PS. "SNAP-29 influences mammalian neuronal development, glutamatergic synapse function and cognitive behavior". Paper presented in The synaptic dimension of brain disorders, 2020.
  8. Pinheiro, PS; Ferreiro, Elisabete; Lanzillo, Mariagrazia; Canhoto, Diogo; Antonio Silva; Mastrella, Giorgia; Fontes, Ana Raquel; Valero, Jorge; Rego, A. Cristina. "Chronic hyperglycemia impairs the maturation of newly-generated hippocampal neurons and exacerbates memory loss in a transgenic mouse model of Alzheimer’s disease". Paper presented in Meeting of the Portuguese Society for Neuroscience, 2017.
  9. Pinheiro, PS; de Luca, P.; Afonso, P.; Mele, M.; Duarte, CB. "BDNF upregulates synaptic expression of GluN2B-NMDAR in cultured hippocampal neurons". Paper presented in 7th Special ISN Conference on Synpatic Function and Dysfunction in Brain Diseases, 2016.
  10. Pinheiro, PS; Houy, S.; Groffen, A.J.; Verhage, M.; Sorensen, J.B.. "Doc2B interacts with Munc13 and SNAREs and acts as an upstream calcium sensor for vesicle priming". Paper presented in 7th Special ISN Conference on Synpatic Function and Dysfunction in Brain Diseases, 2016.
  11. Pinheiro, PS; de Wit, Heidi; Jansen, AM; Verhage, M.; Madsen, K.L.; Gether, U.; Sorensen, J.B.. "The BAR Protein Pick1 controls dense core vesicle size in mouse chromaffin cells". Paper presented in 17th international symposium on chromaffin cell biology, Rouen, France, 2013.
  12. Pinheiro, PS; Sorensen, J.B.. "The implication of Doc2b in vesicle fusion and exocytosis in chromaffin cells". Paper presented in INF Conference, Copenhagen, Denmark, 2012.
  13. Pinheiro, PS; Sorensen, J.B.. "The implication of Doc2B in Dense Core Vesicle Fusion". Paper presented in Neurizons 2011 - From Molecules to Mind: Making Sense of the Brain, Göttingen, Germany, 2011.
  14. Pinheiro, PS; Sorensen, J.B.. "The implication of double C2 domain proteins in vesicle fusion and exocytosis". Paper presented in INF conference, Copenhagen, Denmark, 2011.
  15. Pinheiro, PS; Araújo, IM; Gil, J; Carreira, B.P.; Petersen, Å.; Mohapel, P.; Malva, JO; et al. "Activation of calpains but not of caspases in early excitotoxic neurodegeneration in the hippocampus of epileptic rats". Paper presented in 9th Meeting of the Portuguese Neuroscieince Society, Luso, Portugal, 2005.
  16. Pinheiro, PS; Malva, JO; Silva, AP; Cavadas, C.; Oliveira, CR. "Modulation of presynaptic excitability by kainate and NPY receptors in the rat hippocampus: relevance for epileptogenesis and neuroprotection". Paper presented in 1st Neuroscience Symposium - Natal, Brasil., 2004.
  17. Pinheiro, PS; Araújo, IM; Gil, J; Petersen, Å.; Mohapel, P.; Verdasca, MJ; Malva, JO; et al. "Calpains and neurotoxicity in the hippocampus: lessons from in vitro and in vivo models". Paper presented in 12th ECDO Euroconference on Apoptosis - Chania, Greece, 2004.
  18. Pinheiro, PS; Oliveira, CR; Jakobsen, B.; Zimmer, J.; Malva, JO. "Zinc neurotoxicity in organotypic slice cultures of the rat hippocampus: role of AMPA and kainate receptors". Paper presented in Zinc Signals 2003 4th Annual International Conference, 2003.
  19. Pinheiro, PS; Oliveira, CR; Malva, JO. "Identification of Pre- and Postsynaptic AMPA and Kainate Receptor Subunits in the Rat Hippocampus". Paper presented in 8th Meeting of the Portuguese Neuroscience Society, 2003.
  20. Pinheiro, PS; Xapelli, S.; Silva, AP; Cavadas, C.; Oliveira, CR; Malva, JO. "Sub-cellular Synaptic Distribution of NPY Y2 and Y5 receptor subtypes and NPY levels in Rat Hippocampal Subregions". Paper presented in 8th Meeting of the Portuguese Neuroscience Society, 2003.
  21. Pinheiro, PS; Malva, JO; Oliveira, CR; Jakobsen, B.; Zimmer, J.. "Zinc Neurotoxicity in Organotypic Slice Cultures of the Rat Hippocampus: Involvment of different Glutamate Receptor Subtypes in CA1 and CA3". Paper presented in 16ª Reunião do Grupo de Estudos do Envelhecimento Cerebral e Demência, 2002.
  22. Pinheiro, PS; Silva, AP; Carvalho, AP; Jakobsen, B.; Zimmer, J.; Malva, JO. "Activation of Neuropeptide Receptors Prevents AMPA and Kainate Cell Death in Rat Hippocampal Slice Cultures". Paper presented in III Congress of Research in Medicine, 2002.
  23. Pinheiro, PS; Silva, AP; Oliveira, CR; Malva, JO. "Solubilization and Separation of Pre- and Postsynaptic AMPA and Kainate Receptors in the Rat Hippocampus". Paper presented in III Congress of Research in Medicine, 2002.
  24. Pinheiro, PS; Malva, JO; Salgado, A; Cunha, RA; Oliveira, CR. "Identification and functional characterization of kainate receptors in rat macrophages and microglia". Paper presented in 7th Meeting of the Portuguese Neuroscience Society, 2001.
  25. Pinheiro, PS; Malva, JO; Salgado, A; Cunha, RA; Oliveira CR. "Kainate receptor-like immunoreactivity in macrophages and microglia". Paper presented in 15ª Reunião do Grupo de Estudos do Envelhecimento Cerebral e Demência, 2001.
  26. Pinheiro, PS; Malva, JO; Catarina, CR. "Organotypic cultures of hippocampal slices: Morphological characterization and toxicity studies". Paper presented in XII Congresso Nacional de Bioquímica, 2000.
  27. Pinheiro, PS; Malva, JO; Catarina, CR. "Ca2+ imaging of CA3 mossy fiber nerve terminals in hippocampal slices". Paper presented in II Congress of Research in Medicine, 2000.
Journal article
  1. Mele, Miranda; De Luca, Pasqualino; Santos, Ana Rita; Vieira, Marta; Salazar, Ivan L.; Pinheiro, Paulo S.; Duarte, Carlos B.. "GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons". The FASEB Journal 35 8 (2021): http://dx.doi.org/10.1096/fj.201903061rr.
    10.1096/fj.201903061rr
  2. Mele, Miranda; Vieira, Ricardo; Correia, Bárbara; De Luca, Pasqualino; Duarte, Filipe V.; Pinheiro, Paulo S.; Duarte, Carlos B.. "Transient incubation of cultured hippocampal neurons in the absence of magnesium induces rhythmic and synchronized epileptiform-like activity". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-90486-y.
    10.1038/s41598-021-90486-y
  3. Tawfik, Bassam; Martins, Joana S; Houy, Sébastien; Imig, Cordelia; Pinheiro, Paulo S; Wojcik, Sonja M; Brose, Nils; Cooper, Benjamin H; Sørensen, Jakob Balslev. "Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming". eLife 10 (2021): http://dx.doi.org/10.7554/elife.64527.
    Open access • 10.7554/elife.64527
  4. Pinheiro, PS. "Unraveling the Nanoscopic Organization and Function of Central Mammalian Presynapses With Super-Resolution Microscopy". Frontiers in Neuroscience 14 (2021): http://dx.doi.org/10.3389/fnins.2020.578409.
    10.3389/fnins.2020.578409
  5. Ferreiro, Elisabete; Lanzillo, Mariagrazia; Canhoto, Diogo; Carvalho da Silva, António M.; Mota, Sandra I.; Dias, Inês S.; Ferreira, Ildete L.; et al. "Chronic Hyperglycemia Impairs Hippocampal Neurogenesis and Memory in an Alzheimer’s disease mouse model". Neurobiology of Aging (2020): http://dx.doi.org/10.1016/j.neurobiolaging.2020.04.003.
    10.1016/j.neurobiolaging.2020.04.003
  6. Gowrisankaran, Sindhuja; Houy, Sébastien; del Castillo, Johanna G. Peña; Steubler, Vicky; Gelker, Monika; Kroll, Jana; Pinheiro, Paulo S.; et al. "Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-14993-8.
    Open access • 10.1038/s41467-020-14993-8
  7. Miranda Mele; Ricardo Vieira; Barbara Correia; Filipe V. Duarte; Pinheiro, PS; Carlos B. Duarte. "Rhythmic and synchronized neuronal activity in primary hippocampal cultures incubated transiently in the absence of magnesium: characterization as an in vitro model of epilepsy". Epilepsia (2020):
    Submitted
  8. Pedro Afonso; Pasqualino De Luca; Rafael S. Carvalho; Luísa Cortes; Paulo Pinheiro; Barbara Oliveiros; Ramiro D. Almeida; Miranda Mele; Carlos B. Duarte. "BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons". Science Signaling 12 586 (2019): eaav3577-eaav3577. https://doi.org/10.1126/scisignal.aav3577.
    10.1126/scisignal.aav3577
  9. Mele, M.; De Luca, P; Santos, AR; Vieira, M; Pinheiro, PS; Duarte CB. "GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons". The FASEB Journal (2019):
    Open access • Under revision
  10. Houy S; Groffen AJ; Ziomkiewicz I; Verhage M; Pinheiro PS; Sørensen JB; Houy, S.; et al. "Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.". eLife 6 (2017): http://europepmc.org/abstract/med/29274147.
    10.7554/elife.27000
  11. Agís-Balboa, R.C.; Pinheiro, P.S.; Rebola, N.; Kerimoglu, C.; Benito, E.; Gertig, M.; Bahari-Javan, S.; et al. "Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia". EMBO Journal 36 19 (2017): 2815-2828. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026640250&partnerID=MN8TOARS.
    10.15252/embj.201796821
  12. Walter, A.M.; Müller, R.; Tawfik, B.; Wierda, K.D.; Pinheiro, P.S.; Nadler, A.; McCarthy, A.W.; et al. "Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis". eLife 6 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85049410553&partnerID=MN8TOARS.
    10.7554/eLife.30203
  13. Leal G; Comprido D; de Luca P; Morais E; Rodrigues L; Mele M; Santos AR; et al. "The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons.". eNeuro (2017): http://europepmc.org/abstract/med/29255796.
    10.1523/eneuro.0268-17.2017
  14. Leal, G.; Comprido, D.; de Luca, P.; Morais, E.; Rodrigues, L.; Mele, M.; Santos, A.R.; et al. "The RNA-binding protein hnRNP K mediates the effect of BDNF on dendritic mRNA metabolism and regulates synaptic NMDA receptors in hippocampal neurons". eNeuro 4 6 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85039718465&partnerID=MN8TOARS.
    10.1523/ENEURO.0268-17.2017
  15. Pinheiro PS; Houy S; Sørensen JB. "C2-domain Containing Calcium Sensors in Neuroendocrine Secretion.". (2016): http://europepmc.org/abstract/med/27731902.
    10.1111/jnc.13865
  16. Toft-Bertelsen, T.L.; Ziomkiewicz, I.; Houy, S.; Pinheiro, P.S.; Sorensen, J.B.. "Regulation of Ca2+channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clusters". Molecular Biology of the Cell 27 21 (2016): 3329-3341. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994259455&partnerID=MN8TOARS.
    10.1091/mbc.E16-03-0184
  17. Yasuko Antoku; Peter Dedecker; Paulo S. Pinheiro; Tom Vosch; Jakob Balslev Sørensen. "Spatial distribution and temporal evolution of DRONPA-fused SNAP25 clusters in adrenal chromaffin cells". Photochem. Photobiol. Sci. (2015): http://dx.doi.org/10.1039/c4pp00423j.
    10.1039/c4pp00423j
  18. Man KN; Imig C; Walter AM; Pinheiro PS; Stevens DR; Rettig J; Sørensen JB; et al. "Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis.". eLife 4 NOVEMBER20 (2015): http://europepmc.org/abstract/med/26575293.
    10.7554/elife.10635
  19. Pinheiro, P.S.; Jansen, A.M.; de Wit, H.; Tawfik, B.; Madsen, K.L.; Verhage, M.; Gether, U.; Sørensen, J.B.. "The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells". Journal of Neuroscience 34 32 (2014): 10688-10700. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905715514&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.5132-13.2014
  20. Vergnano, A.M.; Rebola, N.; Savtchenko, L.P.; Pinheiro, P.S.; Casado, M.; Kieffer, B.L.; Rusakov, D.A.; Mulle, C.; Paoletti, P.. "Zinc dynamics and action at excitatory synapses". Neuron 82 5 (2014): 1101-1114. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901768895&partnerID=MN8TOARS.
    10.1016/j.neuron.2014.04.034
  21. Janesh Kumar; Julien Veran; Paulo S. Pinheiro; Axel Athane; David Perrais; Christophe Mulle; Mark L. Mayer. "The GluK3 Ligand Binding Domain has a Zinc Binding Site at the Dimer Interface". Biophysical Journal 104 2 (2013): 272a-272a. https://doi.org/10.1016%2Fj.bpj.2012.11.1526.
    10.1016/j.bpj.2012.11.1526
  22. Walter, A.M.; Pinheiro, P.S.; Verhage, M.; Sørensen, J.B.. "A Sequential Vesicle Pool Model with a Single Release Sensor and a Ca2+-Dependent Priming Catalyst Effectively Explains Ca2+-Dependent Properties of Neurosecretion". PLoS Computational Biology 9 12 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84892688353&partnerID=MN8TOARS.
    10.1371/journal.pcbi.1003362
  23. Pinheiro, P.S.; de Wit, H.; Walter, A.M.; Groffen, A.J.; Verhage, M.; Sørensen, J.B.. "Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release". Journal of Neuroscience 33 42 (2013): 16459-16470. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885441178&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.2656-13.2013
  24. Mohrmann, R.; de Wit, H.; Connell, E.; Pinheiro, P.S.; Leese, C.; Bruns, D.; Davletov, B.; Verhage, M.; Sørensen, J.B.. "Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering". Journal of Neuroscience 33 36 (2013): 14417-14430. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883430611&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.1236-13.2013
  25. Pinheiro, P.S.; Lanore, F.; Veran, J.; Artinian, J.; Blanchet, C.; Crépel, V.; Perrais, D.; Mulle, C.. "Selective block of postsynaptic kainate receptors reveals their function at hippocampal mossy fiber synapses". Cerebral Cortex 23 2 (2013): 323-331. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872315470&partnerID=MN8TOARS.
    10.1093/cercor/bhs022
  26. Hovelsø, N.; Sotty, F.; Montezinho, L.P.; Pinheiro, P.S.; Herrik, K.F.; Mørk, A.. "Therapeutic potential of metabotropic glutamate receptor modulators". Current Neuropharmacology 10 1 (2012): 12-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857705629&partnerID=MN8TOARS.
    10.2174/157015912799362805
  27. Veran, J.; Kumar, J.; Pinheiro, P.; Athané, A.; Mayer, M.; Perrais, D.; Mulle, C.. "Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface". Neuron 76 3 (2012): 565-578. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868660479&partnerID=MN8TOARS.
    10.1016/j.neuron.2012.08.027
  28. Lanore, F.; Blanchet, C.; Fejtova, A.; Pinheiro, P.; Richter, K.; Balschun, D.; Gundelfinger, E.; Mulle, C.. "Impaired development of hippocampal mossy fibre synapses in mouse mutants for the presynaptic scaffold protein Bassoon". Journal of Physiology 588 12 (2010): 2133-2145. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954626422&partnerID=MN8TOARS.
    10.1113/jphysiol.2009.184929
  29. Perrais, D.; Pinheiro, P.S.; Jane, D.E.; Mulle, C.. "Antagonism of recombinant and native GluK3-containing kainate receptors". Neuropharmacology 56 1 (2009): 131-140. http://www.scopus.com/inward/record.url?eid=2-s2.0-58049104342&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2008.08.002
  30. Pinheiro, P.S.; Mulle, C.. "Presynaptic glutamate receptors: physiological functions and mechanisms of action.". Nature reviews. Neuroscience 9 6 (2008): 423-436. http://www.scopus.com/inward/record.url?eid=2-s2.0-44949104175&partnerID=MN8TOARS.
    10.1038/nrn2379
  31. Araújo, I.M.; Gil, J.M.; Carreira, B.P.; Mohapel, P.; Petersen, Å.; Pinheiro, P.S.; Soulet, D.; et al. "Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus". Journal of Neurochemistry 105 3 (2008): 666-676. http://www.scopus.com/inward/record.url?eid=2-s2.0-42449116702&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2007.05181.x
  32. Pinheiro, P.S.; Perrais, D.; Coussen, F.; Barhanin, J.; Bettler, B.; Mann, J.R.; Malva, J.O.; Heinemann, S.F.; Mulle, C.. "GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses". Proceedings of the National Academy of Sciences of the United States of America 104 29 (2007): 12181-12186. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547511221&partnerID=MN8TOARS.
    10.1073/pnas.0608891104
  33. Pinheiro, P.; Mulle, C.. "Kainate receptors". Cell and Tissue Research 326 2 (2006): 457-482. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748932824&partnerID=MN8TOARS.
    10.1007/s00441-006-0265-6
  34. Pinheiro, P.S.; Rodrigues, R.J.; Rebola, N.; Xapelli, S.; Oliveira, C.R.; Malva, J.O.. "Presynaptic kainate receptors are localized close to release sites in rat hippocampal synapses". Neurochemistry International 47 5 (2005): 309-316. http://www.scopus.com/inward/record.url?eid=2-s2.0-22044433723&partnerID=MN8TOARS.
    10.1016/j.neuint.2005.05.007
  35. Silva, A.P.; Xapelli, S.; Pinheiro, P.S.; Ferreira, R.; Lourenço, J.; Cristóvão, A.; Grouzmann, E.; et al. "Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats". Journal of Neurochemistry 93 1 (2005): 163-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-20144388681&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2004.03005.x
  36. Araújo, I.M.; Xapelli, S.; Gil, J.M.A.C.; Mohapel, P.; Petersén, Å.; Pinheiro, P.S.; Malva, J.O.; et al. "Proteolysis of NR2B by calpain in the hippocampus of epileptic rats". NeuroReport 16 4 (2005): 393-396. http://www.scopus.com/inward/record.url?eid=2-s2.0-20144387582&partnerID=MN8TOARS.
    10.1097/00001756-200503150-00017
  37. Rebola, N.; Pinheiro, P.C.; Oliveira, C.R.; Malva, J.O.; Cunha, R.A.. "Subcellular localization of adenosine A1 receptors in nerve terminals and synapses of the rat hippocampus". Brain Research 987 1 (2003): 49-58. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142106470&partnerID=MN8TOARS.
    10.1016/S0006-8993(03)03247-5
  38. Lopes, L.V.; Rebola, N.; Pinheiro, P.C.; Richardson, P.J.; Oliveira, C.R.; Cunha, R.A.. "Adenosine A3 receptors are located in neurons of the rat hippocampus". NeuroReport 14 12 (2003): 1645-1648. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141645291&partnerID=MN8TOARS.
    10.1097/00001756-200308260-00021
  39. Pinheiro, P.S.; Rodrigues, R.J.; Silva, A.P.; Cunha, R.A.; Oliveira, C.R.; Malva, J.O.. "Solubilization and immunological identification of presynaptic a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus". Neuroscience Letters 336 2 (2003): 97-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037448310&partnerID=MN8TOARS.
    10.1016/S0304-3940(02)01217-X
  40. Silva, A.P.; Pinheiro, P.S.; Carvalho, A.P.; Carvalho, C.M.; Jakobsen, B.; Zimmer, J.; Malva, J.O.. "Activation of neuropeptide Y receptors is neuroprotective against excitotoxicity in organotypic hippocampal slice cultures.". The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17 9 (2003): 1118-1120. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037704392&partnerID=MN8TOARS.
Preprint
  1. Carvalho, Ana Luisa; Rodrigues, Beatriz; Leitão, Ricardo; Santos, Mónica; Trofimov, Alexander; Silva, Mariline; Inácio, Ângela; et al. "MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress". 2023. http://dx.doi.org/10.21203/rs.3.rs-3405749/v1.
    10.21203/rs.3.rs-3405749/v1
Thesis / Dissertation
  1. Pinheiro, Paulo; Pinheiro, Paulo César da Silva. "Presynaptic kainate receptors in the hippocampus: a critical role for GluR7 at the mossy fiber synapse". PhD, 2006. http://hdl.handle.net/10316/10149.
  2. Pinheiro, PS. "Organotypic Slice Cultures as a Model to Research Presynaptic Kainate Receptors and Excitotoxicity". Degree, Universidade do Minho, 2001.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/10/15 Orchestrating neurosecretion with multiple calcium sensors CIBB - Neuroscience and Disease thematic strand meeting
Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2019/03/20 Orchestrating neurosecretion with multiple calcium sensors IBIMED seminar series
IBIMED - Universidade de Aveiro (Aveiro, Portugal)
2017/03/30 Modulation of vesicle priming by an upstream, dual-action calcium sensor Invited Seminar
Universidade da Beira Interior (Covilhã, Portugal)
2016/11/04 Regulation of Large Dense Core Vesicle exocytosis by an upstream, dual-action calcium sensor CNC.IBILI winter seminar series
Centro de Neurociênicas e Biologia Celular (Coimbra, Portugal)
2007 Mechanisms for the Facilitation of Mossy Fiber Synaptic Transmission by Presynaptic Kainate Receptors - Minisymposium "Disarming the detonator: Novel insights into hippocampal mossy fiber information processing". SFN Annual Meeting
Society For Neuroscience (San Diego, CA, United States)
2004/12/02 Neuroprotection mediated by neuropeptide Y receptors in the hippocampus XIV Congresso Nacional de Bioquímica
Sociedade Portuguesa de Bioquímica (Vilamoura, Portugal)
2004/02/03 Modulation of glutamate release by neuropeptide Y receptors in epileptic rats – relevance for neuroprotection 7th International NPY Meeting
Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2004/02/03 Involvment of Neuropeptide Y receptors in mediating neuroprotection under excitotoxic conditions 7th International NPY Meeting
Centro de neurociências e Biologia Celular (Coimbra, Portugal)
2003/12/03 Synaptic distribution of kainate receptor subunits in the mouse and rat hippocampus: role in regulating the release of [3H]glutamate XXXIV Annual Meeting of the Portuguese Pharmacological Society
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2002 Subcellular Synaptic Localization of N- and P/Q-type Voltage Sensitive Calcium Channels in Rat Hippocampal Synapses XXXIII Annual Meeting of the Portuguese Pharmacological Society
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019 - Current FMRP regulation of synapse dynamics
Co-supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019 - Current DISSECTING THE ROLES OF SNAP29 IN NEURONAL DEVELOPMENT AND FUNCTION: POSSIBLE IMPLICATIONS IN SCHIZOPHRENIA
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 - Current Synaptic regulation by chronic stress-induced miRNAs
Co-supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016 - Current Lab rotation presentation: SNAP-47: POTENTIAL ROLE IN MEMORY CONSOLIDATION
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/04 - 2021/06 Post-doc Supervision: Electrophysiological characterization of SNAP47 KO mouse brain circuits
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/10/01 - 2020/12/31 Roles of SNAP47 in neuronal function and animal behaviour
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/02/01 - 2020/05/31 Dissecting the roles of SNAP29 in neuronal polarized trafficking and development
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/02 - 2020/03 Bahavior analysis of SNAP47 KO mice
Supervisor
 Medicina Veterinária (Degree)
Escola Universitária Vasco da Gama, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/01/27 - 2020/02/24 Lab rotation - contact with electrophysiology techniques
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019 - 2019 Lab rotation - Behavioural characterization of a new transgenic mouse model
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019 - 2019 Lab rotation: Behavioural characterization of a new transgenic mouse model
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019 - 2019 Roles of SNAP29 in neuronal function and animal behaviour
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017 - 2018 n/a
Co-supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/05/01 - 2017/05/19 Lab rotation - Contact with electrophysiology techniques
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/06/13 - 2016/07/08 Lab rotation - Introduction to electrophysiology techniques
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2014 Postdoc supervision: Role of Doc2B in large dense-core vesicle priming and fusion
Co-supervisor
Københavns Universitet, Denmark
2013 - 2014 Postdoc supervision: Role of SNAP23 in inhibitory and excitatory synaptic transmission
Co-supervisor
Københavns Universitet, Denmark
2011 - 2014 n/a
Co-supervisor
Københavns Universitet, Denmark
2011 - 2014 n/a
Co-supervisor
Københavns Universitet, Denmark

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/10/20 - 2022/10/21 8th European Synapse Meeting, September 2021 (2020)
Congress (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/06/01 - 2016/06/04 7th special meeting of the International Society for Neurochemistry, "synaptic function & dysfunction in brain diseases", S. Francisco Convent, Coimbra (2016/06/01 - 2016/06/04)
Conference (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/09 - Current Demonstration of basic principles of electrophysiology using devices from backyardbrains.com
Other
 European Researcher's Night
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/11 - 2019/11 Supervision of Lab visits by highschool students
Other
 Science and technology week
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/01/07 - 2019/01/18 II Modular Training in Laboratory Animal Science”, (small rodents), Functions A (graded 17.7/20) and B (graded 19.3/20)
Workshop
 Modular Training in Laboratory Animal Science
CNC.IBILI, Portugal
2013/07/13 - 2013/07/17 International Symposium on Chromaffin Cell Biology
Symposium
 17th International Symposium on Chromaffin Cell Biology
Université de Rouen, France
2005/09/04 - 2005/09/09 Gordon Research Conference "Excitatory Amino Acids and Brain Function" Chair, Morgan H. Sheng; Vice Chair, Robert Malenka
Conference
 Gordon Research Conference
2003/05/26 - 2003/06/01 NATO/FEBS advanced workshop, Antalya, Turkey
Workshop
 Frontiers in Neurodegenerative Disorders and Aging: Fundamental Aspects, Clinical Perspectives and New Insights
Federation of European Neuroscience Societies, Belgium
2002/09/11 - 2002/09/14 Neuroimmunology Course, Tampere, Finland
Workshop
 Third course of the European School of Neuroimmunology - ESNI
Tampereen yliopisto, Finland
2001/10/15 - 2001/10/19 Stereotaxic Surgery course
Workshop
 Stereotaxic Surgery for Rodent Models of Neurodegeneration and Repair
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2001/04/16 - 2001/04/20 Workshop on the developmant and plasticity of the vertebrate retina and visual pathway
Workshop
 Development and Plasticity of the Vertebrate Retina and Visual Pathway
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2000/04/10 - 2000/04/14 Workshop on culturing and maintaining organotipic cultures of hippocampal slices
Workshop
 Organotypic Cultures of Hippocampal Slices
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/02/23 The secretome of mesenchymal stem cells induces synapse formation in neurons of the central nervous system.
(Thesis) Main arguer
 Ricardo Araújo Faria, (Master)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2020/07/14 Characterization of protein and transcript levels in amisyn mutant mice
(Thesis) Main arguer
 Joana Sofia Lopes Ferreira (Master)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2020/02/03 The role of endocytosis in BDNF-induce axonal outgrowth and branching
Thesis Member
 Luís Filipe Maximino Martins (PhD)
Universidade de Coimbra, Portugal
2018/09/25 Regulatory Mechanisms of Presenilin on Kainate Receptor Currents at CA3 Pyramidal Cells in Alzheimer´s Disease
(Thesis) Main arguer
 Jorge Miguel Santos Castanheira (Master)
Universidade de Coimbra, Portugal
2018/09/25 The role of hippocampal A2A receptors in the generalization of conditioned fear
(Thesis) Main arguer
 Ana Margarida Pinto da Fonseca Almeida Ribeiro (Master)
Universidade de Coimbra, Portugal
2018/09/12 Measuring dopamine release in different domains of the striatum during development of habitual reward seeking
(Thesis) Main arguer
 João Manuel Silveira de Matos (Master)
Universidade de Coimbra, Portugal
2017/07/19 Role of astrocytes in synaptic function and memory. Focus on adenosine A2A receptors.
(Thesis) Main arguer
 Marlene Cristina Faria Pereira (Master)
Universidade de Coimbra, Portugal
2017/07/07 Modulation of NMDA receptor currents by adenosine A2A receptors in the Schaffer collaterals-CA1 synapses.
(Thesis) Main arguer
 Ana Margarida Cardoso Henriques (Master)
Universidade de Coimbra, Portugal
2016/07/07 The impact of psychotomimetic and antipsychotic molecules on the trafficking of NMDA receptors
(Thesis) Main arguer
 Alexandra Inês Pereira Fernandes (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/11/27 Presynaptic formation and function under the control of ubiquitin and the proteasome
Thesis Member
 Maria Joana Guimarães Pinto (PhD)
Universidade de Coimbra, Portugal
2015/09/16 Interplay between Dopamine and gamma2-AminoButyric Acid type A receptors´ surface dynamics during maturation of neurons and development of hippocampal networks
(Thesis) Main arguer
 Miguel Albino Matias (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Committee member

Activity description
Role 		Institution / Organization
2019 - Current Ethics and Animal Welfare Committee member
Member
 Escola Universitária Vasco da Gama, Portugal
2018 - Current Master project grants committee
Member
 Escola Universitária Vasco da Gama, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2018 - Current Biochemistry II (metabolism) laboratory classes (in French), semester 2 Medicina Veterinária (Mestrado integrado) Escola Universitária Vasco da Gama, Portugal
2017 - Current Biochemistry I (structural biochemistry) laboratory classes (in French), semester 1 Medicina Veterinária (Mestrado integrado) Escola Universitária Vasco da Gama, Portugal
2016 - Current Lecture "Electrophysiology - a primer II" presented in the context of the Neuoscience course of the MIT-Portugal Bio-engineering doctoral program MIT-Portugal Bio-engineering PhD program (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016 - Current Lecture "Mechanisms of Neurotransmitter Release and methods to study them" presented in the context of the neuroscience course of the MIT-Portugal bio-engineering doctoral program MIT-Portugal PhD program (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016 - Current Lecture " Electrophysiology - a primer II" presented in the context of the Synapse structure and function course of the PDBEB PhD program Synapse structure and function (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016 - Current Lecture " Molecular mechanisms of neurotransmitter release" presented in the context of the Synapse structure and function course of the PDBEB PhD program Synapse structure and function (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/11/25 - 2020/12/20 Electrophysiology contact sessions Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2019/10/28 - 2019/11/22 Mechanisms of Neurotransmitter Release – and methods to study them. Lecture at the Cellular and Molecular Neurobiology Course Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2018/11/26 - 2018/12/20 Electrophysiology contact sessions Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2018/11/30 - 2018/11/30 Studying Exocytosis Using Electrophysiology – basic principles and applications (PDF). Lecture presented at the Advanced Course on Intercellular Communication Ciências da Saúde (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/10/22 - 2018/11/16 Lecture: Mechanisms of Neurotransmitter Release – and methods to study them. Cellular and Molecular Neurobiology Course Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2017/12/15 - 2017/12/15 Studying Exocytosis Using Electrophysiology – basic principles and applications (PDF). Lecture presented at the Advanced Course on Intercellular Communication Ciências da Saúde (Doutoramento) Universidade de Coimbra, Portugal
2017/10/30 - 2017/11/10 Lecture: Mechanisms of Neurotransmitter Release – and methods to study them. Cellular and Molecular Neurobiology Course Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2016/11/14 - 2016/11/25 Lecture: Mechanisms of Neurotransmitter Release – and methods to study them. Cellular and Molecular Neurobiology Course Biologia Celular e Molecular (Mestrado) Universidade de Coimbra, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2020/09/08 - Current Frontiers in Synaptic Neuroscience (1663-3563) Frontiers

Mentoring / Tutoring

Topic Student name
2022/02 - 2022/03 Integrated Veterinary Practice. Tutoring of internship in the context of the integrated Master in veterinary medicine, Escola Universitária Vasco da Gama, Coimbra. Lisa Sagot
2022/02 - 2022/03 Integrated Veterinary Practice. Tutoring of internship in the context of the integrated Master in veterinary medicine, Escola Universitária Vasco da Gama, Coimbra. Lisuarte Medeiros
2022/02 - 2022/03 Integrated Veterinary Practice. Tutoring of internship in the context of the integrated Master in veterinary medicine, Escola Universitária Vasco da Gama, Coimbra. Lucas Andrieux
2022/02 - 2022/03 Integrated Veterinary Practice. Tutoring of internship in the context of the integrated Master in veterinary medicine, Escola Universitária Vasco da Gama, Coimbra. Malaurine Afonso
2022/02 - 2022/03 Integrated Veterinary Practice. Tutoring of internship in the context of the integrated Master in veterinary medicine, Escola Universitária Vasco da Gama, Coimbra. Manon Videau
2021/02/01 - 2021/03/01 Integrated Veterinary Practice. Juline Stoffel
2021/02/01 - 2021/03/01 Integrated Veterinary Practice. Jelila Akoone
2021/02/01 - 2021/03/01 Integrated Veterinary Practice. Julie Sá Rodrigues
2021/02/01 - 2021/03/01 Integrated Veterinary Practice. Laura Dufossé
2021/02/01 - 2021/03/01 Integrated Veterinary Practice. Leeloo Stricher
2020/01 - 2020/02 Integrated Veterinary Practice. Manon Hennebert
2020/01 - 2020/02 Integrated Veterinary Practice. Marine Hauchard
2020/01 - 2020/02 Integrated Veterinary Practice. Mathilde Gerbouin
2020/01 - 2020/02 Integrated Veterinary Practice. Matthieu Cazorla
2020/01 - 2020/02 Integrated Veterinary Practice. Salomé Bouniol
2019/01 - 2019/02 Integrated Veterinary Practice. Thibaud Mokrani
2019/01 - 2019/02 Integrated Veterinary Practice. Solène Blanc
2019/01 - 2019/02 Integrated Veterinary Practice. Solène Berger
2019/01 - 2019/02 Integrated Veterinary Practice. Tiffany Oudot
2019/01 - 2019/02 Integrated Veterinary Practice. Olivier San German
2018/01 - 2018/02 Integrated Veterinary Practice. Anaelle Marquier
2018/01 - 2018/02 Integrated Veterinary Practice. Andy Garcia
2018/01 - 2018/02 Integrated Veterinary Practice. Camille Vernières
2018/01 - 2018/02 Integrated Veterinary Practice. Salomé Ferté
2013 - 2013 Capacitance measurements from mouse chromaffin cells Mimi Man
2011 - 2013 Tutoring in electrophysiology capacitance recordings Anders Sonne Munch
2012 - 2012 Electrophysiology capacitance measurements Monica Gelker
2009 - 2012 Tutoing in molecular biology/cloning techniques Leanne Graham
2009 - 2012 Tutoring in molecular biology/cloning lab techniques Lise Hoj Thomson
2009 - 2012 Tutoring in molecular biology/cloning lab techniques Anna Sofie Husted
2009 - 2012 Cell culture/electrophysiology recordings Sophie Bohr Fabricius
2008/09 - 2008/09 two-photon calcium imaging of hippocampal mossy fiber boutons n/a; 2 students
2007/09 - 2007/09 Physiology of hippocampal mossy fiber synapses n/a; 2 students
2006 - 2007 Electrophysiology in brain slices Joana Lourenço
2006/09 - 2006/09 Synaptic physiology of kainate receptors n/a; 2 students
2003 - 2003 General tutoring in laboratory techniques Sara Xapeli
2002 - 2002 Lab tutoring - Preparation of sub-synaptic protein fractions Nelson Rebola
2002 - 2002 Lab tutoring/supervision - preparation of sub-synaptic protein fractions Ricardo Rodrigues

Other jury / evaluation

Activity description Institution / Organization
2018/03 - Current Jury for the defenses of annual intership reports by veterinary medicine students, in the context of the Integrated veterinary practice curricular unit Escola Universitária Vasco da Gama, Portugal
2018 - Current Main arguer of PhD projects: - Mariana Laranjo, “Dissecting the role of parvalbumin positive inhibitory neurons in the cellular and behavioral phenotypes associated with Gprasp2 deletion”, Supervised by João Peça, 2019 - Marina Rodrigues, “Stargazin as a regulator of neuronal activity”, Supervised by Ana Luísa Carvalho, 2018 Universidade de Coimbra, Portugal
2018 - Current Main arguer in Integrated Veterinary Practice report presentations from students of the integrated Master in Veterinary Medicine, Escola Universitária Vasco da Gama, Coimbra, Portugal. Students examined: 13 Escola Universitária Vasco da Gama, Portugal
2020/01/23 - 2020/01/23 Juri member for the selection of a project manager for the ITN syn2psy Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/06/01 - 2019/06/30 Jury member for the recruitment of 2 ESR PhD candidates for the syn2psy ITN Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Distinctions

Award

2016 IBRO/FENS travel grant
International Brain Research Organization, France
2011 Prize for securing EU funding
Københavns Universitet, Denmark
2007 Prize for best research publication - SPN 2007
Sociedade Portuguesa de Neurociências, Portugal
2006 Prize for best PhD thesis
Associação Portuguesa de Doutorados em França (APDF), Portugal
2005 Gulbenkian prize "Research Stimulus"
Fundação Calouste Gulbenkian, Portugal
2001 Grant for Initiation to Scientific Research
Fundação para a Ciência e a Tecnologia, Portugal

Title

2010 FP7 Marie Curie Fellow
European Commission, Belgium

Other distinction

2004 Short-term Fellowship
Fundação Calouste Gulbenkian, Portugal
2004 Short-term Fellowship
2004 Short-term fellowship
Fundação Calouste Gulbenkian, Portugal