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Vânia Castro. Completed the Mestrado in Quimica Medicinal in 2013/12 by Universidade do Minho Centro de Química and Licenciatura in Licenciatura em Química in 2012 by Universidade do Minho Escola de Ciências. Attends the Doutoramento in Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais by Universidade do Minho since 2017/09. Published 12 articles in journals. Has 1 patent(s) registered. Has received 1 awards and/or honors. Participates and/or participated as Master Student Fellow in 1 project(s), PhD Student Fellow in 1 project(s) and Researcher in 5 project(s). Works in the area(s) of Exact Sciences with emphasis on Chemical Sciences with emphasis on Organic Chemistry, Natural sciences with emphasis on Biological Sciences with emphasis on Biochemistry, Medical and Health Sciences with emphasis on Medical Biotechnology with emphasis on Biomaterials, Exact Sciences with emphasis on Chemical Sciences with emphasis on Analytical Chemistry and Exact Sciences with emphasis on Chemical Sciences. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Ciências Naturais::Ciências Químicas; 577.18; 577.112.6; Dialkylglycines; Peptaibolin; Antimicrobial peptides; Model membranes; Conformational studies; Peptaibols; Microwave assisted synthesis; Cryoprotectants; Freeze-thawing; Natural deep eutectic solvents; Sugars; Biochemistry, Genetics and Molecular Biology(all); Agricultural and Biological Sciences(all); Peptide; NMR spectroscopy; Mass spectrometry; HPLC purification; Fluorescence spectroscopy; Membrane active peptides; Unnatural amino acids; MW-SPPS; Membrane permeation; .
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Identification

Personal identification

Full name
Vânia Castro

Citation names

  • Castro, Vânia I. B.
  • Castro, V. I.B.

Author identifiers

Ciência ID
B713-7514-C755
ORCID iD
0000-0002-3061-3954

Email addresses

  • vaniacastro@i3bs.uminho.pt (Professional)

Telephones

Telephone
  • 253510900 (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Exact Sciences - Chemical Sciences - Analytical Chemistry
  • Exact Sciences - Chemical Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Intermediate (B1) Advanced (C1)
Education
Degree Classification
2017/09 - 2021
Ongoing
 Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais (Doutoramento)
Universidade do Minho, Portugal
2011/09 - 2013/12
Concluded
 Quimica Medicinal (Mestrado)
Universidade do Minho Centro de Química, Portugal
"Síntese em fase sólida assistida por microondas de péptidos contendo a,a-dialquilglicinas não naturais" (THESIS/DISSERTATION)
 17
2012
Concluded
 Licenciatura em Química (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"Péptidos com atividade antibiótica: síntese de miméticos" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2016/08/01 - 2017/08/31 Researcher (Research) 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, from I3Bs, University of Minho, Portugal
3B's Research Group - Biomaterials, Biodegradables and Biomimetics, from I3Bs, University of Minho, Portugal
2016/01/04 - 2016/07/29 Researcher (Research) Primor, Charcutaria Prima, Portugal
Primor, Charcutaria Prima, Portugal
(...)
2014/05/01 - 2014/11/30 Researcher (Research) Universidade do Minho Centro de Química, Portugal
Universidade do Minho Centro de Química, Portugal

Others

Category
Host institution 		Employer
2013/02/01 - 2013/10/31 master student Universidade do Minho Centro de Química, Portugal
Universidade do Minho Centro de Química, Portugal
Projects

Grant

Designation Funders
2017/09/01 - 2022/08/31 PhD program on Tissue Engineering, Regenerative Medicine and Stem Cells, (TERM&SC)
PD/BD/135256/2017
COVID/BD/152018/2021
PhD Student Fellow
3B's Research Group - Biomaterials, Biodegradables and Biomimetics, from I3Bs, University of Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/08/01 - 2017/08/31 DESZYME: Biocatalytic separation of enantiomers using Natural Deep Eutectic Solvents
PTDC/BBBEBB/1676/2014
Researcher
3B's Research Group - Biomaterials, Biodegradables and Biomimetics, from I3Bs, University of Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/01/04 - 2016/07/31 COVER-ED
3334
Researcher
Primor, Charcutaria Prima, Portugal

Universidade de Coimbra Departamento de Química, Portugal
European Regional Development Fund

Autoridade de Gestão do Programa Operacional Competitividade e Internacionalização
Concluded
2014/05/01 - 2014/11/30 Structure-based design, biological activity and model membrane permeation studies of antimicrobial peptaibols bearing unnatural amino acids
PTDC/QUI-BIQ/118389/2010
Researcher
Universidade do Minho Centro de Química, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/09/01 - 2025/08/31 "ECaBox ""Eyes in a Care Box"": Regenerating human retina from resuscitated cadaveric eyes"
964342
10.3030/964342
Researcher
European Commission
Ongoing

Other

Designation Funders
2022/10 - 2025/10 RePark - Refining the efficacy of systemic administration of bioactive molecules for Parkinson's Disease
M-ERA-NET3/0007/2021
Researcher
Ongoing
2013/02/01 - 2013/12/31 Structure-based design, biological activity and model membrane permeation studies of antimicrobial peptaibols bearing unnatural amino acids
PTDC/QUI-BIQ/118389/2010
Master Student Fellow
Universidade do Minho Centro de Química, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Castro, Vânia I. B.; Araujo A. R.; Duarte, Filipa; António Sousa-Franco; Reis, Rui L.; Pashkuleva, Iva; Pires, Ricardo A. "Self-Assembling glycopeptide hydrogels induce the differentiation of stem cells into neural lineages". Paper presented in REMIX- Regenerative Medicine Innovation Crossing - Research and Innovation Staff Exchange in Regenerative Medicine, 2023.
  2. Castro, Vânia I. B.; Amorim, Sara; Caballero, David; Abreu, Catarina M.; Reis, Rui L.; Pashkuleva, Iva; Pires, Ricardo. "Micropatterned glycopeptide-based supramolecular hydrogels promote the alignment and contractility of cardiomyocytes". Paper presented in TERMIS-2023, 2023.
  3. Castro, Vânia I. B.; Araujo A. R.; Duarte, Filipa; António Sousa-Franco; Reis, Rui L.; Pashkuleva, Iva; Pires, Ricardo. "Tunable glycopeptide-based supramolecular hydrogels drive the differentiation of stem cells into neural lineages". Paper presented in TERMIS-2023, 2023.
  4. Castro, Vânia I. B.; Araujo A. R.; António Sousa-Franco; Duarte, Filipa; Reis, Rui L.; Pashkuleva, Iva; Pires, Ricardo. "Glycopeptide-based supramolecular hydrogels induce stem cell differentiation into neural lineages". Paper presented in Term_Stem Achilles, 2022.
  5. Castro, Vânia I. B.; Ana Rita Araujo; António Duarte Zapico Bicho de Sousa Franco; Reis, Rui L.; Pashkuleva, Iva; Pires, Ricardo A. "Supramolecular hydrogels induce differentiation of stem cell into neural lineages". Paper presented in Third Achilles Workshop, 2021.
  6. Castro, Vânia I. B.; Ge, J.; Chen, J.; Reis, Rui L.; Pashkuleva, Iva; Pires, Ricardo. "Carbohydrates can code bioinformation by inversion of the supramolecular chirality". Paper presented in TermStem 2019, 2019.
  7. Castro, Vânia I. B.; Yuting Gao; Brito, Alexandra; Soares da Costa, Diana; Jien Chen; Reis, Rui L.; Rein V. Ulijn; Pashkuleva, Iva; Pires, Ricardo. "Carbohydrate stereoisomers self-assemble into supramolecular fibers with different helicity". Paper presented in Glupor13, 2019.
  8. Castro, Vânia I. B.; Gao, Y.; Brito, Alexandra; Soares da Costa, Diana; Chen, J.; Ulijn, R. V.; Reis, Rui L.; Pashkuleva, Iva; Pires, Ricardo. "Out of equilibrium assembly of carbohydrate amphiphiles as a modulator of the supramolecular helicity and gelation". Paper presented in FoReCast 2nd Workshop, 2019.
  9. Yuting Gao; Brito, Alexandra; Jien Chen; Rein V. Ulijn; Reis, Rui L.; Pashkuleva, Iva; Pires, Ricardo A. "Control of supramolecular helicity by the energy input and the monomer stereochemistry". Paper presented in TERMIS-EU 2020 Chapter Meeting, 2019.
  10. Castro, Vânia I. B.; Gao, Y.; A. Brito; Chen, J.; Reis, Rui L.; Pashkuleva, Iva; Pires, Ricardo. "Effect of stereochemistry on the assembly and properties of supramolecular structures made of short aromatic carbohydrate amphiphiles". Paper presented in Chem2Nature_Final Conference, 2018.
  11. Castro, Vânia I. B.; Reis, Rui L.; Pashkuleva, Iva; Pires, Ricardo. "Supramolecular hydrogels generated by short peptide sequences that mimic the extracellular matrix". Paper presented in Chem2Nature, 2018.
  12. Castro, Vânia I. B.; Silva, Joana M.; Reis, Rui L.; Paiva, Alexandre; Duarte, Ana Rita C.. "Natural deep eutectic systems inspired in animals living in extreme environments: cytotoxicity profile". Paper presented in International symposium on Bioinspired Macromolecular Systems, 2017.
  13. Castro, Vânia I. B.; Craveiro, Rita Paula Paiva; Silva, Joana M.; Reis, Rui L.; Paiva, Alexandre; Duarte, Ana Rita C.. "Natural deep eutectic systems as cryoprotective agents for cryopreservation process of cells: Characterization of thermophysical and cytotoxicity properties.". Paper presented in FoReCast 1st Workshop, 2017.
  14. Mano, Francisca; Castro, Vânia I. B.; Barreiros, S.; Reis, Rui L.; Paiva, Alexandre; Duarte, Ana Rita C.. "Coffee Ground Lignocellulosic Fractionation Using Natural Deep Eutectic Solvents Coupled with CO2". Paper presented in The Internation Symposium on Green Chemistry, 2017.
  15. Castro, Vânia I. B.; Mano, Francisca; Margarida S. Miranda; Reis, Rui L.; Paiva, Alexandre; Duarte, Ana Rita C; Duarte, Ana Rita C.. "Physical and thermodynamic properties of natural deep eutectic solvents for cellulose processing". Paper presented in The International Symposium on Green Chemistry, 2017.
  16. Carvalho, Carina Martins; Castro, Vânia I. B.; Pereira-Lima, Sílvia M. M. A.; Costa, Susana P. G.; Castanheira, Elisabete M. S.. "Peptide-induced permeation of model membranes by antimicrobial peptidomimetics". 2015.
  17. Castro, Vânia I. B.; Carvalho, Carina Martins; Costa, Susana P. G.; Lima, Sílvia M. M. A. Pereira. "HPLC purification and structural characterization by NMR spectroscopy and mass spectrometry of Peptaibolin mimetics". 2014.
  18. Carvalho, Carina Martins; Castro, Vânia I. B.; Lima, Sílvia M. M. A. Pereira; Costa, Susana P. G.. "Analysis of permeation of model membranes by Peptaibolin mimetics by fluorescence spectroscopy". 2014.
  19. Castro, Vânia I. B.; Carvalho, Carina Martins; Fernandes, Rui D. V.; Costa, Susana P. G.; Pereira-Lima, Sílvia M. M. A.. "Solid phase microwave assisted synthesis of Peptaibolin mimetics bearing a,a-dialkylglycines". 2013.
  20. Castro, Vânia I. B.; Carvalho, Carina Martins; Fernandes, Rui D. V.; Aguiam, Nádia; Costa, Susana P. G.; Pereira-Lima, Sílvia M. M. A.. "Optimizations studies on the microwave assisted synthesis of antimicrobial Peptaibols". 2013.
  21. Carvalho, Carina Martins; Castro, Vânia I. B.; Costa, Susana P. G.; Pereira-Lima, Sílvia M. M. A.. "NMR and IR conformational studies of the influence of bulky C-tetrasubstituted amino acids on Peptaibolin mimetics". 2013.
  22. Castro, Vânia I. B.; Fernandes, Rui D. V.; Lima, Sílvia M. M. A. Pereira; Costa, Susana P. G.. "Membrane-active peptides bearing unnatural amino acids : studies on solution phase and microwave-assisted solid phase synthesis". 2012.
Journal article
  1. Maria L. Castro-Ribeiro; Vânia I. B. Castro; Joana Vieira de Castro; Ricardo A. Pires; Rui L. Reis; Bruno M. Costa; Helena Ferreira; Nuno M. Neves. "The Potential of the Fibronectin Inhibitor Arg-Gly-Asp-Ser in the Development of Therapies for Glioblastoma". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25094910.
    10.3390/ijms25094910
  2. Vânia Castro; Ana Rita Rodrigues Araújo; Filipa Duarte; António Sousa-Franco; Rui L. Reis; I Pashkuleva; Ricardo A. Pires. Corresponding author: I Pashkuleva. "Glycopeptide-Based Supramolecular Hydrogels Induce Differentiation of Adipose Stem Cells into Neural Lineages". ACS Applied Materials & Interfaces (2023): http://dx.doi.org/10.1021/acsami.3c05309.
    10.1021/acsami.3c05309
  3. Ana Luísa Alves; Ana C Carvalho; Inês Marques Machado; Gabriela S. Diogo; Emanuel M. Fernandes; Vânia I. B. Castro; Ricardo A. Pires; et al. "Cell-Laden Marine Gelatin Methacryloyl Hydrogels Enriched with Ascorbic Acid for Corneal Stroma Regeneration". Bioengineering 10 1 (2023): 62-62. http://dx.doi.org/10.3390/bioengineering10010062.
    10.3390/bioengineering10010062
  4. David S. Freitas; Diana Rocha; Tarsila G. Castro; Jennifer Noro; Vânia Castro; Marta A. Teixeira; Rui L. Reis; Cavaco-Paulo; Silva C.. "Green Extraction of Cork Bioactive Compounds Using Natural Deep Eutectic Mixtures". ACS Sustainable Chemistry & Engineering 10 24 (2022): 7974-7989. http://dx.doi.org/10.1021/acssuschemeng.2c01422.
    10.1021/acssuschemeng.2c01422
  5. "Green extraction of cork bioactive compounds using natural deep eutectic mixtures". Green Chemistry (2022):
    Submitted
  6. Alexandra Brito; Dhwanit Dave; Ayala Lampel; Vânia I. B. Castro; Daniela Kroiss; Rui L. Reis; Tell Tuttle; et al. "Expanding the Conformational Landscape of Minimalistic Tripeptides by Their O-Glycosylation". Journal of the American Chemical Society (2021): https://doi.org/10.1021/jacs.1c07592.
    10.1021/jacs.1c07592
  7. Craveiro, Rita Paula Paiva; Castro, Vânia I. B.; M. T. Viciosa; Dionísio, M; Reis, Rui L.; Ana Rita C. Duarte; Paiva, Alexandre. "Influence of natural deep eutectic systems in water thermal behavior and their applications in cryopreservation". Journal of Molecular Liquids 329 115533 (2021): https://doi.org/10.1016/j.molliq.2021.115533.
    Published
  8. Ana R. Araújo; Vânia I. B. Castro; Rui L. Reis; Ricardo A. Pires. "Glucosamine and Its Analogues as Modulators of Amyloid-ß Toxicity". ACS Medicinal Chemistry Letters 12 4 (2021): 548-554. https://doi.org/10.1021/acsmedchemlett.0c00350.
    10.1021/acsmedchemlett.0c00350
  9. Silva, Joana M.; Pereira, Carolina V.; Mano, Francisca; Silva, Eduardo; Castro, Vânia I. B.; Sá-Nogueira, Isabel; Reis, Rui L.; et al. "Therapeutic Role of Deep Eutectic Solvents Based on Menthol and Saturated Fatty Acids on Wound Healing". ACS Applied Bio Materials 2 10 (2019): 4346-4355. http://dx.doi.org/10.1021/acsabm.9b00598.
    10.1021/acsabm.9b00598
  10. Castro, Vânia I.B.; Craveiro, Rita; Silva, Joana M.; Reis, Rui L.; Paiva, Alexandre; C. Duarte, Ana Rita. "Natural deep eutectic systems as alternative nontoxic cryoprotective agents". Cryobiology 83 (2018): 15-26. http://dx.doi.org/10.1016/j.cryobiol.2018.06.010.
    10.1016/j.cryobiol.2018.06.010
  11. Castro, Vânia I. B.; Mano, Francisca; Reis, Rui L.; Paiva, Alexandre; Duarte, Ana Rita C.. "Synthesis and Physical and Thermodynamic Properties of Lactic Acid and Malic Acid-Based Natural Deep Eutectic Solvents". Journal of Chemical & Engineering Data 63 7 (2018): 2548-2556. http://dx.doi.org/10.1021/acs.jced.7b01037.
    Published • 10.1021/acs.jced.7b01037
  12. Castro, Vânia I. B.. "Peptaibolin analogues by incorporation of a,a-dialkylglycines: synthesis and study of their membrane permeating ability". Eur. J. Org. Chem (2015):
    10.1016/j.tet.2015.12.079
  13. Aguiam, Nádia R.; Castro, Vânia I. B.; Ribeiro, Ana I.F.; Fernandes, Rui D.V.; Carvalho, Carina M.; Costa, Susana P.G.; Pereira-Lima, Sílvia M.M.A.. "a,a-Dialkylglycines obtained by solid phase Ugi reaction performed over isocyanide functionalized resins". Tetrahedron 69 43 (2013): 9161-9165. http://dx.doi.org/10.1016/j.tet.2013.08.002.
    10.1016/j.tet.2013.08.002
Thesis / Dissertation
  1. Castro, Vânia I. B.. "Síntese em fase sólida assistida por micro-ondas de péptidos contendo a, a-dialquilglicinas não naturais". Master, 2013. http://hdl.handle.net/1822/29418.

Intellectual property

Patent
  1. Castro, Vânia I. B.; Silva, Joana M.; Craveiro, Rita; Reis, Rui L.; Paiva, Alexandre; Duarte, Ana Rita C.. 2017. "A cryopreservation composition and methods thereof".
    Granted/Issued
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/09/05 Self-Assembling glycopeptide hydrogels for neuronal differentiation ESB2023
(Davos, Switzerland)
2022/06/30 Glycopeptide-based supramolecular hydrogels induce differentiation of stem cells into neural lineages TERMIS EU 2022
(Kravów, Poland)
2019/09/25 Different energy inputs promotes helicity change in the supramolecular arrangement of carbohydrates 1st Discoveries Forum on Regenerative and Precision Medicine
(Porto, Portugal)
2019/09/04 Carbohydrate stereoisomers self-assemble into supramolecular fibers with different helicity Glupor 13
(Porto, Portugal)
2017/06/05 Natural deep eutectic solvents inspired in animals living in extreme environments: Characterization of physical and cytotoxicity properties The Internation Symposium on Green Chemistry
(La Rochelle, France)

Committee member

Activity description
Role 		Institution / Organization
2022/03/02 - Current PhD student representative from I3B’s of the University of Minho
Member
 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, from I3Bs, University of Minho, Portugal
Distinctions

Award

2017 PhD scholarship in the Doctoral Programme in Tissue Engineering, Regenerative Medicine and Stem Cells, (TERM&SC)
3B's Research Group - Biomaterials, Biodegradables and Biomimetics, from I3Bs, University of Minho, Portugal