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Reto Gassmann is a group leader at the Institute for Research and Innovation in Health (i3S) in Porto interested in the function and regulation of the major microtubule minus end-directed motor in animal cells, cytoplasmic dynein 1 (dynein). Reto studied biochemistry and molecular biology at the Swiss Federal Institute of Technology (ETH) in Zurich and joined the group of Prof. Bill Earnshaw at the Wellcome Centre for Cell Biology in Edinburgh, UK, for graduate research on mitotic chromosome segregation. In 2005, he moved to the USA for postdoctoral work in the group of Prof. Arshad Desai at the Ludwig Institute for Cancer Research in La Jolla, CA, where he continued to work on cell division and started research on dynein in the animal model Caenorhabditis elegans. In 2012, he joined the Institute for Molecular and Cell Biology in Porto (now part of i3S) as a Principal Investigator and became a group leader in 2014. His group uses live-cell fluorescence microscopy, genetics, and biochemical approaches in C. elegans and human cultured cells to study dynein function and regulation during chromosome segregation and intracellular transport. Current projects focus on adaptor proteins, which bring dynein together with its processivity factor dynactin and establish a link between the motor and its diverse cargo. The goal is to uncover general and cargo-specific mechanisms underlying assembly and activation of the dynein-dynactin transport machine in different cellular and developmental contexts.
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Identification

Personal identification

Full name
Reto Gassmann
Gender
Male

Citation names

  • Gassmann, Reto

Author identifiers

Ciência ID
B816-8F36-DF36
ORCID iD
0000-0002-0360-2977

Email addresses

  • rgassmann@ibmc.up.pt (Professional)

Telephones

Telephone
  • 220408800 Ext.: 6125 (Professional)

Addresses

  • Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
Education
Degree Classification
2001/10/01 - 2005/06/21
Concluded
 PhD (Doctor of Philosophy)
Major in Cell Biology
The University of Edinburgh College of Science and Engineering, United Kingdom
"Identification and characterization of borealin, a novel subunit of the vertebrate chromosomal passenger complex" (THESIS/DISSERTATION)
1996/10/21 - 2001/05/04
Concluded
 Molecular Biology and Biochemistry (Master of Science ETH) (Master)
Major in Molecular Biology and Biochemistry
Eidgenössische Technische Hochschule Zürich Departement Biologie, Switzerland
"Subcellular fate of the MMTV envelope protein signal peptide" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2015/01/01 - Current Principal Investigator (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012/01/01 - Current Principal Investigator (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2005/06/15 - 2011/12/31 Postdoc (Research) Ludwig Institute for Cancer Research San Diego Branch, United States
Projects

Grant

Designation Funders
2022/01 - 2024/12 Axonal transport regulation by motor-cargo adaptors
PTDC/BIA-CEL/1321/2021
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2018/06/01 - 2021/05/31 Molecular mechanisms of the dynein-dynactin transport machinery in health and disease
NORTE-01-0145-FEDER-030507
PTDC/BIA-CEL/30507/2017
Principal investigator
Fundação para a Ciência e a Tecnologia
Concluded
2014/03/01 - 2019/10/31 Cytoplasmic Dynein: Mechanisms of Regulation and Novel Interactors
ERC-2013-StG-338410-DYNEINOME
Principal investigator
European Research Council
Ongoing
2013/01/01 - 2017/12/31 Molecular mechanisms of cytoplasmic dynein regulators
EMBO Installation Grant 2545
Principal investigator
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Zanin, E.; Dumont, J.; Gassmann, R.; Cheeseman, I.; Maddox, P.; Bahmanyar, S.; Carvalho, A.; et al. Affinity Purification of Protein Complexes in C. elegans. 2011.
    10.1016/B978-0-12-544172-8.00011-6
Journal article
  1. Cátia Carvalho; Daniel J Barbosa; Ricardo Celestino; Esther Zanin; Ana Xavier Carvalho; Reto Gassmann; M Boxem. "Dynein directs prophase centrosome migration to control the stem cell division axis in the developing Caenorhabditis elegans epidermis". GENETICS (2024): https://doi.org/10.1093/genetics/iyae005.
    10.1093/genetics/iyae005
  2. Gonçalves-Santos, Francisco; De-Castro, Ana R.G.; Rodrigues, Diogo R.M.; De-Castro, Maria J.G.; Gassmann, Reto; Abreu, Carla M.C.; Dantas, Tiago J.. "Hot-wiring dynein-2 establishes roles for IFT-A in retrograde train assembly and motility". Cell Reports 42 11 (2023): 113337. http://dx.doi.org/10.1016/j.celrep.2023.113337.
    10.1016/j.celrep.2023.113337
  3. Inês C. Santos; Ana M. Silva; Reto Gassmann; Ana X. Carvalho. "Anillin and the microtubule bundler PRC1 maintain myosin in the contractile ring to ensure completion of cytokinesis". Development (2023): https://doi.org/10.1242/dev.201637.
    10.1242/dev.201637
  4. Helder Rocha; Patrícia A. Simões; Jacqueline Budrewicz; Pablo Lara-Gonzalez; Ana Xavier Carvalho; Julien Dumont; Arshad Desai; Reto Gassmann. "Nuclear-enriched protein phosphatase 4 ensures outer kinetochore assembly prior to nuclear dissolution". Journal of Cell Biology (2023): https://doi.org/10.1083/jcb.202208154.
    10.1083/jcb.202208154
  5. Reto Gassmann. "Dynein at the kinetochore". Journal of Cell Science (2023): https://doi.org/10.1242/jcs.220269.
    10.1242/jcs.220269
  6. Silva, A.M.; Chan, F.-Y.; Norman, M.J.; Sobral, A.F.; Zanin, E.; Gassmann, R.; Belmonte, J.M.; Carvalho, A.X.. "ß-heavy-spectrin stabilizes the constricting contractile ring during cytokinesis". The Journal of cell biology 222 1 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85139739598&partnerID=MN8TOARS.
    10.1083/jcb.202202024
  7. De-Castro, A.R.G.; Rodrigues, D.R.M.; De-Castro, M.J.G.; Vieira, N.; Vieira, C.; Carvalho, A.X.; Gassmann, R.; Abreu, C.M.C.; Dantas, T.J.. "WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing". The Journal of cell biology 221 1 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85123025569&partnerID=MN8TOARS.
    10.1083/jcb.202010178
  8. Celestino, R.; Gama, J.B.; Castro-Rodrigues, A.F.; Barbosa, D.J.; Rocha, H.; D’Amico, E.A.; Musacchio, A.; et al. "JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport". Journal of Cell Biology 221 8 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85134435160&partnerID=MN8TOARS.
    10.1083/jcb.202110057
  9. Daniel J. Barbosa; Vanessa Teixeira; Joana Duro; Ana X. Carvalho; Reto Gassmann. "Dynein-dynactin segregate meiotic chromosomes in C. elegans spermatocytes". Development (2021): dev.197780-dev.197780. https://doi.org/10.1242/dev.197780.
    10.1242/dev.197780
  10. Gassmann, R.. "Cell Division: Chromatin Dynamics Shape Insect Holocentromeres". Current Biology 31 1 (2021): R34-R37. http://www.scopus.com/inward/record.url?eid=2-s2.0-85098774621&partnerID=MN8TOARS.
    10.1016/j.cub.2020.10.049
  11. Sobral, A.F.; Chan, F.-Y.; Norman, M.J.; Osório, D.S.; Dias, A.B.; Ferreira, V.; Barbosa, D.J.; et al. "Plastin and spectrin cooperate to stabilize the actomyosin cortex during cytokinesis". Current Biology 31 24 (2021): 5415-5428.e10. http://www.scopus.com/inward/record.url?eid=2-s2.0-85121234178&partnerID=MN8TOARS.
    10.1016/j.cub.2021.09.055
  12. Kops, G.J.P.L.; Gassmann, R.. "Crowning the Kinetochore: The Fibrous Corona in Chromosome Segregation". Trends in Cell Biology (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85084228116&partnerID=MN8TOARS.
    10.1016/j.tcb.2020.04.006
  13. Conde, C.; Gassmann, R.. "Spindle checkpoint: trapped by the corona, cyclin B1 goes MAD". EMBO Journal (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85086043496&partnerID=MN8TOARS.
    10.15252/embj.2020105279
  14. Leite, J.; Chan, F.-Y.; Osório, D.S.; Saramago, J.; Sobral, A.F.; Silva, A.M.; Gassmann, R.; Carvalho, A.X.. "Equatorial Non-muscle Myosin II and Plastin Cooperate to Align and Compact F-actin Bundles in the Cytokinetic Ring". Frontiers in Cell and Developmental Biology 8 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85092498962&partnerID=MN8TOARS.
    10.3389/fcell.2020.573393
  15. Chan, F.-Y.; Silva, A.M.; Saramago, J.; Pereira-Sousa, J.; Brighton, H.E.; Pereira, M.; Oegema, K.; Gassmann, R.; Carvalho, A.X.. "The ARP2/3 complex prevents excessive formin activity during cytokinesis". Molecular biology of the cell 30 1 (2019): 96-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059257752&partnerID=MN8TOARS.
    10.1091/mbc.E18-07-0471
  16. Celestino, R.; Henen, M.A.; Gama, J.B.; Carvalho, C.; McCabe, M.; Barbosa, D.J.; Born, A.; et al. "A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport". PLoS biology 17 1 (2019): e3000100-e3000100. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060185140&partnerID=MN8TOARS.
    10.1371/journal.pbio.3000100
  17. Osório, D.S.; Chan, F.-Y.; Saramago, J.; Leite, J.; Silva, A.M.; Sobral, A.F.; Gassmann, R.; Carvalho, A.X.. "Crosslinking activity of non-muscle myosin II is not sufficient for embryonic cytokinesis in C. elegans". Development (Cambridge, England) 146 21 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074964249&partnerID=MN8TOARS.
    10.1242/dev.179150
  18. Rocha, H.; Maia, A.F.; Gassmann, R.. "Data Descriptor: A genome-scale RNAi screen for genetic interactors of the dynein co-factor nud-2 in Caenorhabditis elegans". Scientific Data 5 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85044305058&partnerID=MN8TOARS.
    10.1038/sdata.2018.47
  19. Simões, P.A.; Celestino, R.; Carvalho, A.X.; Gassmann, R.. "NudE regulates dynein at kinetochores but is dispensable for other dynein functions in the C. elegans early embryo". Journal of Cell Science 131 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85042557731&partnerID=MN8TOARS.
    10.1242/jcs.212159
  20. Pereira, C.; Reis, R.M.; Gama, J.B.; Celestino, R.; Cheerambathur, D.K.; Carvalho, A.X.; Gassmann, R.. "Self-Assembly of the RZZ Complex into Filaments Drives Kinetochore Expansion in the Absence of Microtubule Attachment". Current Biology 28 21 (2018): 3408-3421.e8. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055739143&partnerID=MN8TOARS.
    10.1016/j.cub.2018.08.056
  21. Barbosa, D.J.; Duro, J.; Prevo, B.; Cheerambathur, D.K.; Carvalho, A.X.; Gassmann, R.. "Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport". PLoS Genetics 13 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85026624927&partnerID=MN8TOARS.
    10.1371/journal.pgen.1006941
  22. Gama, J.B.; Pereira, C.; Simões, P.A.; Celestino, R.; Reis, R.M.; Barbosa, D.J.; Pires, H.R.; et al. "Molecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly". Journal of Cell Biology 216 4 (2017): 943-960. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021847678&partnerID=MN8TOARS.
    10.1083/jcb.201610108
  23. Silva, A.M.; Osório, D.S.; Pereira, A.J.; Maiato, H.; Pinto, I.M.; Rubinstein, B.; Gassmann, R.; Telley, I.A.; Carvalho, A.X.. "Robust gap repair in the contractile ring ensures timely completion of cytokinesis". Journal of Cell Biology 215 6 (2016): 789-799. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009223214&partnerID=MN8TOARS.
    10.1083/jcb.201605080
  24. Maia, A.F.; Tanenbaum, M.E.; Galli, M.; Lelieveld, D.; Egan, D.A.; Gassmann, R.; Sunkel, C.E.; Van Den Heuvel, S.; Medema, R.H.. "Genome-wide RNAi screen for synthetic lethal interactions with the C. elegans kinesin-5 homolog BMK-1". Scientific Data 2 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84960970688&partnerID=MN8TOARS.
    10.1038/sdata.2015.20
  25. Holland, A.J.; Reis, R.M.; Niessen, S.; Pereira, C.; Andres, D.A.; Spielmann, H.P.; Cleveland, D.W.; Desai, A.; Gassmann, R.. "Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors". Molecular Biology of the Cell 26 10 (2015): 1845-1856. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929440905&partnerID=MN8TOARS.
    10.1091/mbc.E14-11-1560)
  26. Varma, D.; Wan, X.; Cheerambathur, D.; Gassmann, R.; Suzuki, A.; Lawrimore, J.; Desai, A.; Salmon, E.D.. "Spindle assembly checkpoint proteins are positioned close to core microtubule attachment sites at kinetochores". Journal of Cell Biology 202 5 (2013): 735-746. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884170422&partnerID=MN8TOARS.
    10.1083/jcb.201304197
  27. Earnshaw, W.C.; Allshire, R.C.; Black, B.E.; Bloom, K.; Brinkley, B.R.; Brown, W.; Cheeseman, I.M.; et al. "Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant". Chromosome Research 21 2 (2013): 101-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880573233&partnerID=MN8TOARS.
    10.1007/s10577-013-9347-y
  28. Cheerambathur, D.K.; Gassmann, R.; Cook, B.; Oegema, K.; Desai, A.. "Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation". Science 342 6163 (2013): 1239-1242. http://www.scopus.com/inward/record.url?eid=2-s2.0-84889245451&partnerID=MN8TOARS.
    10.1126/science.1246232
  29. Gassmann, R.; Rechtsteiner, A.; Yuen, K.W.; Muroyama, A.; Egelhofer, T.; Gaydos, L.; Barron, F.; et al. "An inverse relationship to germline transcription defines centromeric chromatin in C. elegans". Nature 484 7395 (2012): 534-537. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860253153&partnerID=MN8TOARS.
    10.1038/nature10973
  30. Stevens, D.; Gassmann, R.; Oegema, K.; Desai, A.. "Uncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrest". PLoS ONE 6 8 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79960988207&partnerID=MN8TOARS.
    10.1371/journal.pone.0022969
  31. Liu, W.; Tanasa, B.; Tyurina, O.V.; Zhou, T.Y.; Gassmann, R.; Liu, W.T.; Ohgi, K.A.; et al. "PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression". Nature 466 7305 (2010): 508-512. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954954200&partnerID=MN8TOARS.
    10.1038/nature09272
  32. Gassmann, R.; Holland, A.J.; Varma, D.; Wan, X.; Çivril, F.; Cleveland, D.W.; Oegema, K.; Salmon, E.D.; Desai, A.. "Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells". Genes and Development 24 9 (2010): 957-971. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951875761&partnerID=MN8TOARS.
    10.1101/gad.1886810
  33. Gerstein, M.B.; Lu, Z.J.; Van Nostrand, E.L.; Cheng, C.; Arshinoff, B.I.; Liu, T.; Yip, K.Y.; et al. "Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project". Science 330 6012 (2010): 1775-1787. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650410139&partnerID=MN8TOARS.
    10.1126/science.1196914
  34. Nakano, M.; Cardinale, S.; Noskov, V.N.; Gassmann, R.; Vagnarelli, P.; Kandels-Lewis, S.; Larionov, V.; Earnshaw, W.C.; Masumoto, H.. "Inactivation of a Human Kinetochore by Specific Targeting of Chromatin Modifiers". Developmental Cell 14 4 (2008): 507-522. http://www.scopus.com/inward/record.url?eid=2-s2.0-41849114919&partnerID=MN8TOARS.
    10.1016/j.devcel.2008.02.001
  35. Gassmann, R.; Essex, A.; Hu, J.-S.; Maddox, P.S.; Motegi, F.; Sugimoto, A.; O'Rourke, S.M.; et al. "A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex". Genes and Development 22 17 (2008): 2385-2399. http://www.scopus.com/inward/record.url?eid=2-s2.0-51149118049&partnerID=MN8TOARS.
    10.1101/gad.1687508
  36. Yue, Z.; Carvalho, A.; Xu, Z.; Yuan, X.; Cardinale, S.; Ribeiro, S.; Lai, F.; et al. "Deconstructing Survivin: Comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line". Journal of Cell Biology 183 2 (2008): 279-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-55949106979&partnerID=MN8TOARS.
    10.1083/jcb.200806118
  37. Gassmann, R.; Kline, S.L.; Carvalho, A.; Desai, A.. "Analysis of kinetochore assembly and function in Caenorhabditis elegans embryos and human cells". Methods 41 2 (2007): 177-189. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845781985&partnerID=MN8TOARS.
    10.1016/j.ymeth.2006.07.027
  38. Gassmann, R.; Henzing, A.J.; Earnshaw, W.C.. "Novel components of human mitotic chromosomes identified by proteomic analysis of the chromosome scaffold fraction". Chromosoma 113 7 (2005): 385-397. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844266228&partnerID=MN8TOARS.
    10.1007/s00412-004-0326-0
  39. Gassmann, R.; Carvalho, A.; Henzing, A.J.; Ruchaud, S.; Hudson, D.F.; Honda, R.; Nigg, E.A.; Gerloff, D.L.; Earnshaw, W.C.. "Borealin: A novel chromosomal passenger required for stability of the bipolar mitotic spindle". Journal of Cell Biology 166 2 (2004): 179-191. http://www.scopus.com/inward/record.url?eid=2-s2.0-3342887700&partnerID=MN8TOARS.
    10.1083/jcb.200404001
  40. Gassmann, R.; Vagnarelli, P.; Hudson, D.; Earnshaw, W.C.. "Mitotic chromosome formation and the condensin paradox". Experimental Cell Research 296 1 (2004): 35-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-2142656052&partnerID=MN8TOARS.
    10.1016/j.yexcr.2004.03.006
  41. Hudson, D.F.; Vagnarelli, P.; Gassmann, R.; Earnshaw, W.C.. "Condensin is required for nonhistone protein assembly and structural integrity of vertebrate mitotic chromosomes". Developmental Cell 5 2 (2003): 323-336. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041440100&partnerID=MN8TOARS.
    10.1016/S1534-5807(03)00199-0
Preprint
  1. Carvalho, Cátia; Barbosa, Daniel J.; Celestino, Ricardo; Zanin, Esther; Carvalho, Ana Xavier; Gassmann, Reto. "Dynein directs prophase centrosome migration to control the stem cell division axis in the developingC. elegansepidermis". 2023. http://dx.doi.org/10.1101/2023.09.25.559295.
    10.1101/2023.09.25.559295
  2. Gonçalves-Santos, Francisco; De-Castro, Ana R. G.; Rodrigues, Diogo R. M.; De-Castro, Maria J. G.; Gassmann, Reto; Abreu, Carla M. C.; Dantas, Tiago J.. "Hot-wiring dynein-2 uncovers roles for IFT-A in retrograde train assembly and motility". 2023. http://dx.doi.org/10.1101/2023.05.10.539247.
    10.1101/2023.05.10.539247
  3. Rocha, Helder; Simões, Patrícia A.; Budrewicz, Jacqueline; Lara-Gonzalez, Pablo; Carvalho, Ana Xavier; Dumont, Julien; Desai, Arshad; Gassmann, Reto. "Nuclear-enriched protein phosphatase 4 ensures outer kinetochore assembly prior to nuclear dissolution". 2022. http://dx.doi.org/10.1101/2022.09.01.505886.
    10.1101/2022.09.01.505886
  4. Singh, Kashish; Lau, Clinton K.; Manigrasso, Giulia; Gama, José B.; Gassmann, Reto; Carter, Andrew P.. "Molecular mechanism of dynein-dynactin activation by JIP3 and LIS1". 2022. http://dx.doi.org/10.1101/2022.08.17.504273.
    10.1101/2022.08.17.504273
  5. Celestino, Ricardo; Gama, José B.; Castro-Rodrigues, Artur F.; Barbosa, Daniel J.; d’Amico, Ennio A.; Musacchio, Andrea; Carvalho, Ana Xavier; Morais-Cabral, João H.; Gassmann, Reto. "JIP3 regulates bi-directional organelle transport in neurons through its interaction with dynein and kinesin-1". 2021. http://dx.doi.org/10.1101/2021.10.11.463801.
    10.1101/2021.10.11.463801
  6. De-Castro, Ana R. G.; Rodrigues, Diogo R. M.; De-Castro, Maria J. G.; Vieira, Neide; Vieira, Cármen; Carvalho, Ana X.; Gassmann, Reto; Abreu, Carla M.; Dantas, Tiago J.. "WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing". 2021. http://dx.doi.org/10.1101/2021.09.19.459328.
    10.1101/2021.09.19.459328
  7. Barbosa, Daniel J.; Teixeira, Vanessa; Duro, Joana; Carvalho, Ana X.; Gassmann, Reto. "Dynein-dynactin segregate meiotic chromosomes in C. elegans spermatocytes". 2020. http://dx.doi.org/10.1101/2020.10.19.345041.
    10.1101/2020.10.19.345041
  8. Osorio, DS; Chan, FY; Saramago, J; Leite, J; Silva, AM; Sobral, AF; Gassmann, R; Carvalho, AX. "Flow-independent accumulation of motor-competent non-muscle myosin II in the contractile ring is essential for cytokinesis". 2018. http://dx.doi.org/10.1101/333286.
    10.1101/333286
  9. Pereira, Cláudia; Reis, Rita M.; Gama, José B.; Cheerambathur, Dhanya K.; Carvalho, Ana X.; Gassmann, Reto. "Self-assembly of the RZZ complex into filaments drives kinetochore expansion in the absence of microtubule attachment". 2018. http://dx.doi.org/10.1101/282707.
    10.1101/282707
  10. Barbosa, Daniel José; Duro, Joana; Cheerambathur, Dhanya K.; Prevo, Bram; Carvalho, Ana Xavier; Gassmann, Reto. "Dynactin binding to tyrosinated microtubules promotes centrosome centration inC. elegansby enhancing dynein-mediated organelle transport". 2017. http://dx.doi.org/10.1101/130104.
    10.1101/130104
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/01/01 - Current Dissecting the mechanisms of ciliary gating: interplay between Dynein-2 and the transition zone
Co-supervisor
 PhD (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/01/01 - Current Dissecting the NDE1/LIS1-dependent regulation of Dynein-mediated transport in the brain
Co-supervisor
 PhD (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/01/01 - Current A novel dynein adaptor for the ER involved in ER organization
Supervisor
 PhD (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/01/01 - 2024 Functional characterization of the microtubule motor dynein in the C. elegans epidermis
Supervisor
 PhD (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/01/01 - 2024 Uncovering the mechanisms regulating the essential roles of dynein-2 in cilia function
Co-supervisor
 PhD (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/03/01 - 2023/10/13 Functional Dissection of the Dynein Cargo Adaptor JIP3/UNC-16 in C. elegans
Supervisor
 Master (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2013/01/01 - 2019/10/07 Pathogenic variants in movement disorders: modifiers, interactors and disease models
Co-supervisor
 PhD (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/09/01 - 2019/10/01 Identification of novel conserved dynein pathway genes using a genome-wide synthetic lethal screen in C. elegans
Supervisor
 PhD (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/09/01 - 2019/03/20 Functional dissection of dynein cofactors in mitosis
Supervisor
 PhD (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/09/01 - 2018/11/27 Dissecting the role of Caenorhabditis elegans dynein light intermediate chain in neuronal trafficking
Supervisor
 Master (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2015/09/01 - 2016/11/24 Defining the role of dynactin's microtubule binding activity during cell division
Supervisor
 Master (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2013/09/01 - 2014/12/19 Biochemical characterization of interactions between kinetochore protein complexes
Supervisor
 Master (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2013/09/01 - 2014/10/20 Functional characterization of dynein cofactors in the one-cell C. elegans embryo
Supervisor
 Master (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/09/08 - 2021/09/09 Dynein 2021 International Workshop (2021/09/08 - 2021/09/09)
Conference (Member of the Organising Committee)

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/11/24 Molecular mechanisms underlying robust mitotic checkpoint activation
(Thesis) Main arguer
 Inês Sofia Pinto Antunes (Master)
Universidade do Porto, Portugal
2023/10/13 Functional Dissection of the Dynein Cargo Adaptor JIP3/UNC-16 in C. elegans
Supervisor
 Ana Matilde Ribeiro Moreira (Master)
Universidade do Porto, Portugal
2023/02/16 Structural basis for PP2A-mediated regulation of accurate chromosome segregation
(Thesis) Main arguer
 Paula Sotelo Parrilla (PhD)
The University of Edinburgh, United Kingdom
2022/12/19 Identification of novel CENP-A maintenance mechanisms
(Thesis) Main arguer
 Sebastiaan Jan Wigger van den Berg (PhD)
Universidade Nova de Lisboa, Portugal
2022/12/14 Feedback Regulation Behind Age-associated CellCycle Slow Down as a Potential Anti-aging Target
(Thesis) Main arguer
 Filipa Gaspar do Espírito Santo Martins da Silva (Master)
Universidade do Porto, Portugal
2022/10/12 Investigating Dynein-2 regulation during intraflagellar transport in Cilia
(Thesis) Main arguer
 Francisco Gonçalves Santos (Master)
Universidade do Porto, Portugal
2022/09/21 Biophysics of mitotic spindle assembly
(Thesis) Arguer
 Vanessa Nunes (PhD)
Universidade do Porto, Portugal
2022/03/10 The Roles of Branched Microtubule Nucleation and Kinetochore Architecture in Chromosome Congression and Segregation
(Thesis) Arguer
 Ana Isabel Coelho de Almeida (PhD)
Universidade do Porto, Portugal
2021/03/19 Dissecting the role of polo kinase in the regulation of kinetochore-microtubule attachments
(Thesis) Main arguer
 João Francisco Portugal antas de Barros Barbosa (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/12/02 Ciliary recruitment of the dynein-2 motor and its role in C. elegans sensory functions
(Thesis) Main arguer
 Ana Rita Gonçalves de Castro (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/09/15 Formation of the CenH3-independent holocentromere in Lepidoptera avoids active chromatin
Thesis Member
 Aruni Prabhashwari Senaratne (PhD)
Institut Curie, France
2020/05/29 The role of microtubule detyrosination in mitotic fidelity
(Thesis) Arguer
 Ana Luísa Teixeira Ferreira (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2019/11/20 Identification of Novel Conserved Dynein Pathway Genes Using a Genome-wideSynthetic Lethal Screen in C. elegans
Supervisor
 Helder Henrique Ribeiro Rocha (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/11/11 Dissecting the mechanism of dynein recruitment to the nuclear envelope during neocortical development
(Thesis) Main arguer
 João Carlos Lima Gonçalves (PhD)
Universidade do Minho Escola de Ciências da Saúde, Portugal
2019/10/07 Pathogenic variants in movement disorders: modifiers, interactors and disease models
(Thesis) Arguer
 Maria da Conceição Moutinho Pedroso Pereira (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/06/03 Spindle assembly in the C. elegans embryo
(Thesis) Main arguer
 Alexandra Bondaz (PhD)
Universite de Geneve, Switzerland
2019/03/20 Functional dissection of dynein cofactors in mitosis
Supervisor
 Patrícia Alexandra Carvalho Simões (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/03/08 The role of nuclear positioning in muscle function
(Thesis) Main arguer
 Mafalda Ramos de Melo Pimentel (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018/11/27 Dissecting the Role of Caenorhabditis elegans Dynein Light Intermediate Chain in Neuronal Trafficking
Supervisor
 Cátia Filipa Vieira de Carvalho (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/07/03 Mechanisms of chromosome alignment and segregation during mitosis in Caenorhabditis elegans zygotes
(Thesis) Main arguer
 Frances Edwards (PhD)
Université Paris Diderot, France
2018/04/30 Determining the mechanism of the CSR-1 RNAi pathway in organizing holocentromeres in Caenorhabditis elegans
Thesis Member
 Yan Yu Charmaine Wong (PhD)
Chinese University of Hong Kong, Hong Kong SAR China
2017/05/29 The role of chromosome arms and kinetochore architecture in the formation of amphitelic attachments - implications for mitotic fidelity
(Thesis) Arguer
 Danica Drpic (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/11/24 Defining the role of dynactin's microtubule binding activity during cell division
Supervisor
 Joana Maria Duro Fernandes (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/06/08 Quantitative centromere epigenetics: accurate maintenance of centromeric CENP-A levels
(Thesis) Arguer
 Daniel Bodor (PhD)
Instituto Gulbenkian de Ciência, Portugal
2014/12/19 Biochemical characterization of interactions between kinetochore protein complexes
Supervisor
 João Rodrigues Amorim (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/11/25 Condensin: a dynamic organizer of vertebrate chromosome structure
Thesis Member
 Ji Hun Kim (PhD)
The University of Melbourne, Australia
2014/10/20 Functional Characterization of Dynein Cofactors in the One-Cell C. elegans Embryo
Supervisor
 Patrícia Alexandra Carvalho Simões (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/05/22 Kinetochore-microtubule interaction and regulation
(Thesis) Main arguer
 Tália Cláudia Moreira Figueiredo (PhD)
Universidade do Porto Faculdade de Ciências, Portugal
2013/12/03 Probing MPS1 function in mitosis
(Thesis) Main arguer
 Tale Sliedrecht (PhD)
Universitair Medisch Centrum Utrecht, Netherlands

Association member

Society Organization name Role
2005/01/01 - Current American Society for Cell Biology

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021/03/16 - 2021/03/16 Hcéres evaluation of the Institute of Genetics and Development (IGDR), Rennes
Evaluator
 Institut de Génétique et Développement de Rennes, France Haut Conseil de l'évaluation de la recherche et de l'enseignement supérieur
Distinctions

Other distinction

2019 Stimulus of Scientific Employment Individual Support
Fundação para a Ciência e a Tecnologia, Portugal
2014 Development Grant from the FCT Investigator Programme
Fundação para a Ciência e a Tecnologia, Portugal
2012 Marie Curie Fellow of the Welcome II Programme
Fundação para a Ciência e a Tecnologia, Portugal
2010 Kerr Award for Research Excellence
Ludwig Institute for Cancer Research San Diego Branch, United States
2003 Iain Clark Memorial Prize (best performance by a second year PhD student)
Wellcome Centre for Cell Biology, United Kingdom