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John Griffith Jones is currently a Senior Researcher in the Center of Neurosciences at the University of Coimbra, Portugal. His longstanding research focus has been the use of stable isotopes and NMR spectroscopy to study metabolic fluxes in different organisms, ranging from yeast to humans. He completed his Ph.D. at the University of Texas at Arlington under the supervision of Dr Edward Bellion, where he applied 13C- and 15N-enriched stable isotope tracers and NMR spectroscopy to study metabolic fluxes in methylotrophic yeast. He then moved to the Lab of Craig Malloy and Dean Sherry at the Department of Radiology at U.T. Southwestern Medical Center in Dallas where he initially studied Krebs cycle fluxes in isolated perfused hearts using the 13C NMR isotopomer analyses and modeling methods that was being developed by this group. He became interested in hepatic Krebs cycle metabolism and contributed to the modeling of futile pyruvate cycling by 13C isotopomer analysis and integrating Krebs cycle flux information with gluconeogenesis by combining the Landau deuterated water measurement of gluconeogenesis with 13C isotopomer analysis After moving to Coimbra, Portugal, he applied this approach for characterizing the nutrient precursors of hepatic glycogen synthesis. Currently, he is developing methods for identifying the nutrient sources of acetyl-CoA for hepatic de novo lipogenesis and fatty acid elongation. Outside of research, he has longstanding passions for fly-fishing, golf and brewing beer.
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Identification

Personal identification

Full name
John Griffith Jones

Citation names

  • Jones, John

Author identifiers

Ciência ID
B81B-FD5E-E743
ORCID iD
0000-0002-3745-3885

Knowledge fields

  • Medical and Health Sciences - Health Sciences - Nutrition, Dietetics

Languages

Language Speaking Reading Writing Listening Peer-review
Welsh (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese Upper intermediate (B2) Upper intermediate (B2) Elementary (A2) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
1985/09/01 - 1991/05/01
Concluded
 Applied Chemistry (Doctor of Philosophy)
University of Texas at Arlington, United States
1981/09/15 - 1985/05/31
Concluded
 Biology and Chemistry (Bachelor)
University of Stirling, United Kingdom
Affiliation

Science

Category
Host institution 		Employer
1999/01/01 - 2000/10/31 Principal Investigator (Research) The University of Texas Southwestern Medical Center, United States
The University of Texas Southwestern Medical Center, United States
1995/06/01 - 1999/01/01 Auxiliary Researcher (Research) The University of Texas Southwestern Medical Center, United States
The University of Texas Southwestern Medical Center, United States
1991/06/01 - 1995/05/31 Postdoc (Research) The University of Texas Southwestern Medical Center, United States
The University of Texas Southwestern Medical Center, United States

Positions / Appointments

Category
Host institution 		Employer
2002/04/01 - Current Principal Investigator - Research Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Others

Category
Host institution 		Employer
2000/11/01 - 2001/10/31 Marie Curie Experienced Researcher Fellowship Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Projects

Grant

Designation Funders
2023/06/01 - 2027/05/31 PAS GRAS - de-risking metabolic, environmental and behavioural determinants of obesity in children, adolescents and young adults
HORIZON-HLTH-2022-STAYHLTH-01-101080329-2
Co-Principal Investigator (Co-PI)
EU Framework Programme for Research and Innovation Secure Societies
Ongoing
2023/10/01 - 2026/09/30 High-sensitivity 13C NMR isotopomer analysis of human liver metabolite enrichment from [U-13C]glucose via a novel chemical biopsy agent: application to metabolic flux profiling of NAFLD and NASH patients
P020421
Principal investigator
National High Magnetic Field Laboratory, United States
 National Science Foundation
Ongoing
2025/02/20 - 2026/08/19 Measuring hepatic polyol pathway activity and connecting it with lipogenic glucose metabolism in Type 2 Diabetes patients
2023.11517.PEX
Principal investigator
Ongoing
2024/01/01 - 2025/12/31 Pentose phosphate pathway and serine oxidation fluxes in NAFLD and NASH
77183119
Principal investigator
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Pfizer Global Research and Development
Ongoing
2022/01/01 - 2024/12/31 Developing H218O as a tracer of carbohydrate metabolism: Positional analysis of liver glycerol and glycogen 18O-enrichment by isotope-shifted 13C and 31P NMR
P19803
Principal investigator
Ongoing
2017/01/01 - 2021/12/31 Metabolism and the Liver-Gut Axis in Non-Alcoholic Fatty Liver Disease
H2020-MSCA-RISE-2016-734719
H2020-MSCA-ITN-2016-722619
Co-Principal Investigator (Co-PI)
European Commission
Concluded
2017/01/01 - 2021/12/31 Metabolic dysfunctions associated with pharmacological treatment of Schizophrenia
H2020-MSCA-ITN-2016-721236
Co-Principal Investigator (Co-PI)
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
Concluded
2018/11/01 - 2021/10/31 High-sensitivity 13C NMR isotopomer analysis of triglyceride fatty acid enrichment from [U-13C]fructose
P17827
Principal investigator
National High Magnetic Field Laboratory, United States
 National Science Foundation
Concluded
2019/07/01 - 2021/06/30 Coffee protects against NAFLD progression through preservation of intestinal permeability and inhibition of liver fibrosis
ISIC
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 The Institute for Scientific Information on Coffee (ISIC)
Concluded
2018/06/01 - 2021/05/31 The Role of Visceral Fructose Metabolism in the Development of Non-alcoholic Fatty Liver Disease
02/SAICT/2017/028147
Principal investigator
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/05/01 - 2019/04/30 Reducing nitrogenous waste production of farmed seabass by dietary glycerol supplementation
PTDC/CVT-NUT/2851/2014
Co-Principal Investigator (Co-PI)
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2016/01 - 2019/04 Prognostic and Protective Roles of the Clusterin-PON1 axis Against Obesity Complications
PTDC/BIM-MET/4265/2014
124913
Provided by PTCRIS: 124913
Co-Principal Investigator (Co-PI)
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2013/06 - 2016/05 Anticipating diabetes and diabetic wounding for siblings of Type 2 diabetics.
124979
Provided by PTCRIS: 124979
Co-Principal Investigator (Co-PI)
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2013/04/01 - 2016/03/31 UC NMR: a voyage from chemical space to biological function
RECI/QEQ-QFI/0168/2012
Co-Principal Investigator (Co-PI)
Fundação para a Ciência e a Tecnologia
Concluded
2013/01 - 2015/12 Identification and validation of biomarker genes to improve the production of Sparus aurata by optimizing the use of dietary nutrients
MICINN AGL2012-33305
Co-Principal Investigator (Co-PI)
Ministro de Economia e Competitividad
Concluded
2013/08 - 2015/07 The Effect of TCF7L2 on Glucose Metabolism
DK 078646-06
Consultant
National Institutes of Health Office of the Director
Concluded
2011/07/01 - 2014/06/30 Role of the intestine in promoting the lipogenic effects of fructose
PTDC-SAU-MET-111398-2009
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/04 - 2013/09 Optimizing carbohydrate utilization in farmed sea-bass through metabolic profiling
Provided by PTCRIS: 98111
98111
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2009/08 - 2012/07 Effect of Transaldolase Enzyme Pathway on Gluconeogenesis in People with Prediabetes
DK29953
Consultant
National Institutes of Health Office of the Director
Concluded
2007/10 - 2010/12 Disruption of hepatic glucose and lipid metabolism by immunosuppressive agents: implications for diagnosis and treatment of posttransplant diabetes
Provided by PTCRIS: 65140
65140
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2006/05/01 - 2008/12/31 Noninvasive measurement of hepatic glycogen kinetics in Type 1 diabetics
1-2006-74
Principal investigator
Juvenile Diabetes Research Foundation International
Concluded
2005/09 - 2008/08 Improvement of insulin oral availability through encapsulation in polyelectrolyte complex nanoparticles
Provided by PTCRIS: 59940
59940
Collaborator
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2005/10 - 2008/06 Study of the possible environmental and molecular mechanisms responsible for Insulin Resistance, Type 2 Diabetes and Obesity in Portugal
82373
Provided by PTCRIS: 82373
Provided by PTCRIS: 109279
109279
Co-Principal Investigator (Co-PI)
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2005/10 - 2007/09 Hepatic intermediary metabolism of glucose in children with and without hepatic glucose-6-phosphatase activity
POCTI/QUI/55603/2004
Principal investigator
Fundação para a Ciência e a Tecnologia
Concluded
2005/10 - 2007/06 Design of new Vanadium compounds: towards their application as anti-diabetic and anti-cancer agents
Provided by PTCRIS: 56949
Collaborator
Fundação para a Ciência e a Tecnologia
Concluded
2004/04 - 2005/07 Noninvasive assessment of hepatic glycogen metabolism in Type 1 diabetics
5-2004-306
Principal investigator
Juvenile Diabetes Research Foundation International
Concluded
1991/06/01 - 2000/10/31 Southwestern NMR Center for in Vivo Metabolism
P41RR002584
Integration into Research Grant Fellow
National Center for Advancing Translational Sciences
Concluded
Outputs

Publications

Book
  1. Jones, John. Dietary Sugars. Royal Society of Chemistry. 2012.
    10.1039/9781849734929
  2. Jones, John. Carbohydrate Chemistry. Royal Society of Chemistry. 2011.
    10.1039/9781849732765
  3. Jones, J.G.. Tracing Hepatic Glucose and Glycogen Fluxes with 2H2O. 2007.
    10.1002/9780470513095.ch8
Book chapter
  1. Viegas, Ivan; Albuquerque Carvalho, Rui de; ngelo, Miguel; Griffith, John. "Advances and Applications of Tracer Measurements of Carbohydrate Metabolism in Fish". In New Advances and Contributions to Fish Biology. InTech, 2012.
    10.5772/54053
  2. Barosa, C.; Jones, J. G.. "Recent Developments in the use of Stable Isotope Carbohydrate Tracers for the Study of Human Health". edited by Rauter, A. P.; Lindhorst, T. K., 208-226. 2011.
    10.1039/9781849732765-00208
  3. Jones, John. "Chapter 8: Recent developments in the use of stable isotope carbohydrate tracers for the study of human health in carbohydrate chemistry". 2011.
  4. Jones, John. "Chapter 6: Direct and indirect pathways of hepatic glycogen synthesis in normal and in insulin resistant states". In Advances in Medicine and Biology. 2010.
  5. Jones, John. "Chapter 8: Tracing hepatic glucose and glycogen fluxes with 2H2O". In Clinical Diabetes Research: Methods and Techniques. 2007.
Journal article
  1. Margarida Coelho; João Capela; Vera M. Mendes; João Pacheco; Margarida Sá Fernandes; Isabel Amendoeira; John G. Jones; Luís Raposo; Bruno Manadas. "Peptidomics Unveils Distinct Acetylation Patterns of Histone and Annexin A1 in Differentiated Thyroid Cancer". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms25010376.
    10.3390/ijms25010376
  2. Margarida Coelho; João Capela; Sandra I. Anjo; João Pacheco; Margarida Sá Fernandes; Isabel Amendoeira; John G. Jones; Luís Raposo; Bruno Manadas. "Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241914542.
    10.3390/ijms241914542
  3. Vitor Ferreira; Cintia Folgueira; María García-Altares; Maria Guillén; Mónica Ruíz-Rosario; Giada DiNunzio; Irma Garcia-Martinez; et al. "Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition". Redox Biology 63 (2023): 102741-102741. http://dx.doi.org/10.1016/j.redox.2023.102741.
    10.1016/j.redox.2023.102741
  4. João Pessoa; Getachew D. Belew; Cristina Barroso; Conceição Egas; John G. Jones. "The Gut Microbiome Responds Progressively to Fat and/or Sugar-Rich Diets and Is Differentially Modified by Dietary Fat and Sugar". Nutrients (2023): https://doi.org/10.3390/nu15092097.
    10.3390/nu15092097
  5. Margarida Coelho; Patarrao RS; Inês Sousa-Lima; Rogério T. Ribeiro; Maria João Meneses; Rita Andrade; Vera M. Mendes; et al. "Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes". Nutrients (2022): https://www.mdpi.com/2072-6643/15/1/4.
    10.3390/nu15010004
  6. Ivan Viegas; Giada Di Nunzio; Getachew D. Belew; Alejandra N. Torres; João G. Silva; Luis Perpétuo; Cristina Barosa; Ludgero C. Tavares; John G. Jones. "Integration of Liver Glycogen and Triglyceride NMR Isotopomer Analyses Provides a Comprehensive Coverage of Hepatic Glucose and Fructose Metabolism". Metabolites (2022): https://doi.org/10.3390/metabo12111142.
    10.3390/metabo12111142
  7. Getachew Debas Belew; John G. Jones. "De novo lipogenesis in non-alcoholic fatty liver disease: Quantification with stable isotope tracers". European Journal of Clinical Investigation (2022): https://doi.org/10.1111/eci.13733.
    10.1111/eci.13733
  8. Coelho, Margarida; Mahar, Rohit; Belew, Getachew D.; Torres, Alejandra; Barosa, Cristina; Cabral, Fernando; Viegas, Ivan; et al. "Enrichment of hepatic glycogen and plasma glucose from (H2O)-O-18 informs gluconeogenic and indirect pathway fluxes in naturally feeding mice". NMR in Biomedicine (2022): https://publons.com/wos-op/publon/54600422/.
    10.1002/NBM.4837
  9. Patricio, Joao S.; Dias-Pedroso, Daniela; Carvalho, Rui A.; Viera, Helena L. A.; Jones, John G.. "A simple method for quantifying de novo lipogenesis rate and substrate selection in cell cultures by C-13 NMR isotopomer analysis of the crude lipid fraction". NMR in Biomedicine (2022): https://publons.com/wos-op/publon/50808444/.
    10.1002/NBM.4648
  10. Amorim, Ricardo; Cagide, Fernando; Tavares, Ludgero C.; Simoes, Rui F.; Soares, Pedro; Benfeito, Sofia; Baldeiras, Ines; et al. "Mitochondriotropic antioxidant based on caffeic acid AntiOxCIN(4) activates Nrf2-dependent antioxidant defenses and quality control mechanisms to antagonize oxidative stress-induced cell damage". Free Radical Biology and Medicine (2022): https://publons.com/wos-op/publon/51770689/.
    10.1016/J.FREERADBIOMED.2021.12.304
  11. Molina-Molina, Emilio; Furtado, Guilherme Eustaquio.; Jones, John G.; Portincasa, Piero; Vieira-Pedrosa, Ana; Teixeira, Ana Maria; Barros, Marcelo Paes; Bachi, Andre Luis Lacerda; Sardao, Vilma A.. "The advantages of physical exercise as a preventive strategy against NAFLD in postmenopausal women". European Journal of Clinical Investigation (2022): https://publons.com/wos-op/publon/49682785/.
    10.1111/ECI.13731
  12. Amorim, Ricardo; Simoes, Ines C. M.; Teixeira, Jose; Cagide, Fernando; Potes, Yaiza; Soares, Pedro; Carvalho, Adriana; et al. "Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems". Redox Biology (2022): https://publons.com/wos-op/publon/53932683/.
    10.1016/J.REDOX.2022.102400
  13. John G. Jones. "Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy". Metabolites 11 11 (2021): 751-751. https://doi.org/10.3390/metabo11110751.
    10.3390/metabo11110751
  14. Cristina Barosa; Rogério T. Ribeiro; Rita Andrade; João F. Raposo; John G. Jones. "Effects of Meal Fructose/Glucose Composition on Postprandial Glucose Appearance and Hepatic Glycogen Synthesis in Healthy Subjects". Journal of Clinical Medicine (2021): https://doi.org/10.3390/jcm10040596.
    10.3390/jcm10040596
  15. Dias-Pedroso, Daniela; Ramalho, Jose S.; Sardao, Vilma A.; Jones, John G.; Romao, Carlos C.; Oliveira, Paulo J.; Vieira, Helena L. A.. "Carbon Monoxide-Neuroglobin Axis Targeting Metabolism Against Inflammation in BV-2 Microglial Cells". Molecular Neurobiology (2021): https://publons.com/wos-op/publon/50262822/.
    10.1007/S12035-021-02630-4
  16. Borges, Diego O.; Patarrao, Rita S.; Ribeiro, Rogerio T.; de Oliveira, Rita Machado; Duarte, Nadia; Belew, Getachew Debas; Martins, Madalena; et al. "Loss of postprandial insulin clearance control by Insulin-degrading enzyme drives dysmetabolism traits". Metabolism (2021): https://publons.com/wos-op/publon/41702324/.
    10.1016/J.METABOL.2021.154735
  17. Sousa, Luis; Guarda, Mariana; Meneses, Maria Joao; Macedo, M. Paula; Vicente Miranda, Hugo. "Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases". The Journal of Pathology (2021): https://publons.com/wos-op/publon/49707570/.
    10.1002/PATH.5777
  18. Laurenti, Marcello C.; Dalla Man, Chiara; Varghese, Ron T.; Andrews, James C.; Jones, John G.; Barosa, Cristina; Rizza, Robert A.; et al. "Insulin Pulse Characteristics and Insulin Action in Non-diabetic Humans". The Journal of Clinical Endocrinology & Metabolism (2021): https://publons.com/wos-op/publon/46827652/.
    10.1210/CLINEM/DGAB100
  19. Torres, Alejandra N.; Tavares, Ludgero; Pereira, Maria J.; Eriksson, Jan W.; Jones, John G.. "Positional and compositional analysis of saturated, monounsaturated, and polyunsaturated fatty acids in human adipose tissue triglyceride by C-13 nuclear magnetic resonance". NMR in Biomedicine (2021): https://publons.com/wos-op/publon/50291978/.
    10.1002/NBM.4632
  20. Sousa-Lima, Ines; Kim, Hyun Jeong; Jones, John; Kim, Young-Bum. "Rho-Kinase as a Therapeutic Target for Nonalcoholic Fatty Liver Diseases". Diabetes & Metabolism Journal (2021): https://publons.com/wos-op/publon/55608243/.
    10.4093/DMJ.2021.0197
  21. Jones, John. "Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice". Scientific Reports (2020): http://dx.doi.org/10.1038/s41598-020-69820-3.
    10.1038/s41598-020-69820-3
  22. Getachew D. Belew; Giada Di Nunzio; Ludgero Tavares; Joao G. Silva; Alejandra N. Torres; John G. Jones. "Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13 C-isotopomers derived from [U- 13 C]fructose and [U- 13 C]glucose". Magnetic Resonance in Medicine 84 5 (2020): 2765-2771. https://doi.org/10.1002/mrm.28286.
    10.1002/mrm.28286
  23. Jones, John. "Metabolic incorporation of H 2 18 O into specific glucose-6-phosphate oxygens by red-blood-cell lysates as observed by 13 C isotope-shifted NMR signals". NMR in Biomedicine (2020): http://dx.doi.org/10.1002/nbm.4395.
    10.1002/nbm.4395
  24. Margarida Coelho; Luis Raposo; Brian J. Goodfellow; Luigi Atzori; John Jones; Bruno Manadas. "The Potential of Metabolomics in the Diagnosis of Thyroid Cancer". International Journal of Molecular Sciences 21 15 (2020): 5272-5272. https://doi.org/10.3390/ijms21155272.
    10.3390/ijms21155272
  25. Jones, John. "Monounsaturated fat rapidly induces hepatic gluconeogenesis and whole-body insulin resistance". JCI Insight (2020): http://dx.doi.org/10.1172/jci.insight.134520.
    10.1172/jci.insight.134520
  26. Jones, John. "Limitations to Starch Utilization in Barramundi (Lates calcarifer) as Revealed by NMR-Based Metabolomics". Frontiers in Physiology (2020): http://dx.doi.org/10.3389/fphys.2020.00205.
    10.3389/fphys.2020.00205
  27. Barosa, Cristina; Shanmugam, Harshitha; Cabral, Fernando; Jones, John G.. "p-Aminobenzoic acid as an alternative chemical biopsy agent for human hepatic UDP-glucose". Analytical Biochemistry 590 (2020): 113511. http://dx.doi.org/10.1016/j.ab.2019.113511.
    10.1016/j.ab.2019.113511
  28. Getachew Debas Belew; Joao Silva; Joao Rito; Ludgero Tavares; Ivan Viegas; Jose Teixeira; Paulo J. Oliveira; Maria Paula Macedo; John G. Jones. "Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis". Journal of Lipid Research 60 12 (2019): 2050-2056. https://doi.org/10.1194/jlr.RA119000354.
    10.1194/jlr.RA119000354
  29. Silva, João C.P.; Marques, Cátia; Martins, Fátima O.; Viegas, Ivan; Tavares, Ludgero; Macedo, Maria Paula; Jones, John G.. "Determining contributions of exogenous glucose and fructose to de novo fatty acid and glycerol synthesis in liver and adipose tissue". Metabolic Engineering 56 (2019): 69-76. http://dx.doi.org/10.1016/j.ymben.2019.08.018.
    10.1016/j.ymben.2019.08.018
  30. Caroline D. Veloso; Getachew D. Belew; Luciana L. Ferreira; Luís F. Grilo; John G. Jones; Piero Portincasa; Vilma A. Sardão; Paulo J. Oliveira. "A Mitochondrial Approach to Cardiovascular Risk and Disease". Current Pharmaceutical Design 25 29 (2019): 3175-3194. https://doi.org/10.2174/1389203720666190830163735.
    10.2174/1389203720666190830163735
  31. Jones, John. "27th Annual Meeting of the European Group for the study of Insulin Resistance, Lisbon, Portugal, 8–9th May 2019". Cardiovascular Endocrinology & Metabolism (2019): http://dx.doi.org/10.1097/xce.0000000000000179.
    10.1097/xce.0000000000000179
  32. Jonás I. Silva-Marrero; Juliana Villasante; Ania Rashidpour; Mariana Palma; Anna Fàbregas; María Pilar Almajano; Ivan Viegas; et al. "The Administration of Chitosan-Tripolyphosphate-DNA Nanoparticles to Express Exogenous SREBP1a Enhances Conversion of Dietary Carbohydrates into Lipids in the Liver of Sparus aurata". Biomolecules 9 8 (2019): 297-297. https://doi.org/10.3390/biom9080297.
    10.3390/biom9080297
  33. Araújo, Pedro M.; Viegas, Ivan; Rocha, Afonso D.; Villegas, Auxiliadora; Jones, John G.; Mendonça, Liliana; Ramos, Jaime A.; Masero, José A.; Alves, José A.. "Understanding how birds rebuild fat stores during migration: insights from an experimental study". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-46487-z.
    10.1038/s41598-019-46487-z
  34. Viegas, Ivan; Trenkner, Lauren H.; Rito, João; Palma, Mariana; Tavares, Ludgero C.; Jones, John G.; Glencross, Brett D.; Wade, Nicholas M.. "Impact of dietary starch on extrahepatic tissue lipid metabolism in farmed European (Dicentrarchus labrax) and Asian seabass (Lates calcarifer)". Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 231 (2019): 170-176. http://dx.doi.org/10.1016/j.cbpa.2019.02.025.
    10.1016/j.cbpa.2019.02.025
  35. Rito, João; Viegas, Ivan; Pardal, Miguel Â.; Metón, Isidoro; Baanante, Isabel V.; Jones, John G.. "Utilization of glycerol for endogenous glucose and glycogen synthesis in seabass (Dicentrarchus labrax): A potential mechanism for sparing amino acid catabolism in carnivorous fish". Aquaculture 498 (2019): 488-495. http://dx.doi.org/10.1016/j.aquaculture.2018.08.066.
    10.1016/j.aquaculture.2018.08.066
  36. Jarak, Ivana; Barosa, Cristina; Martins, Fatima O.; Silva, Joao C. P.; Santos, Cristiano; Belew, Getachew Debas; Rito, Joao; et al. "Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate". Magnetic Resonance in Medicine 81 1 (2018): 639-644. http://dx.doi.org/10.1002/mrm.27378.
    10.1002/mrm.27378
  37. Silva, João C. P.; Mota, Marta; Martins, Fátima O.; Nogueira, Célia; Gonçalves, Teresa; Carneiro, Tatiana; Pinto, Joana; et al. "Intestinal Microbial and Metabolic Profiling of Mice Fed with High-Glucose and High-Fructose Diets". Journal of Proteome Research 17 8 (2018): 2880-2891. http://dx.doi.org/10.1021/acs.jproteome.8b00354.
    10.1021/acs.jproteome.8b00354
  38. Rito, Joao; Viegas, Ivan; Pardal, Miguel A.; Meton, Isidoro; Baanante, Isabel V.; Jones, John G.. "Disposition of a Glucose Load into Hepatic Glycogen by Direct and Indirect Pathways in Juvenile Seabass and Seabream". Scientific Reports 8 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000419941000005&KeyUID=WOS:000419941000005.
    10.1038/s41598-017-19087-y
  39. Huang, Hu; Lee, Seung-Hwan; Sousa-Lima, Ines; Kim, Sang Soo; Hwang, Won Min; Dagon, Yossi; Yang, Won-Mo; et al. "Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition". Journal of Clinical Investigation 128 12 (2018): 5335-5350. https://publons.com/wos-op/publon/19310035/.
    10.1172/JCI63562
  40. Viegas, Ivan; Araujo, Pedro M.; Rocha, Afonso D.; Villegas, Auxiliadora; Jones, John G.; Ramos, Jaime A.; Masero, Jose A.; Alves, Jose A.. "Metabolic plasticity for subcutaneous fat accumulation in a longdistance migratory bird traced by (H2O)-H-2". Journal of Experimental Biology 220 6 (2017): 1072-1078. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000397614200019&KeyUID=WOS:000397614200019.
    10.1242/jeb.150490
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  48. Coelho, Margarida; Valente-Silva, Paula; Tylki-Szymanska, Anna; Henriques, Tiago; Barosa, Cristina; Carvalho, Filipa; Jones, John G.; Jones, John G. "Demonstration of Glucose-6-Phosphate Hydrogen 5 Enrichment from Deuterated Water by TransaldolaseMediated Exchange Alone". Magnetic Resonance in Medicine 75 4 (2016): 1781-1786. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000372910900040&KeyUID=CCC:000372910900040.
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  53. Martins, Fatima O.; Delgado, Teresa C.; Viegas, Joana; Gaspar, Joana M.; Scott, Donald K.; O'Doherty, Robert M.; Macedo, M. Paula; Jones, John G.. "Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia". British Journal of Pharmacology 173 2 (2016): 267-278. https://publons.com/wos-op/publon/2029575/.
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  56. Burgess, Shawn C.; Merritt, Mathew E.; Jones, John G.; Browning, Jeffrey D.; Sherry, A. Dean; Malloy, Craig R.. "Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-C-13] acetate". Nature Medicine 21 2 (2015): 20-21. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000348974800007&KeyUID=CCC:000348974800007.
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  57. Valente-Silva, Paula; Lemos, Cristina; Koefalvi, Attila; Cunha, Rodrigo A.; Jones, John G.. "Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices". Nmr in Biomedicine 28 9 (2015): 1111-1116. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359809800006&KeyUID=WOS:000359809800006.
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  58. Viegas, Ivan; Rito, Joao; Jarak, Ivana; Leston, Sara; Caballero-Solares, Albert; Meton, Isidoro; Pardal, Miguel A.; Baanante, Isabel V.; Jones, John G.. "Contribution of dietary starch to hepatic and systemic carbohydrate fluxes in European seabass (Dicentrarchus labrax L.)". British Journal of Nutrition 113 9 (2015): 1345-1354. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000355283800002&KeyUID=WOS:000355283800002.
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  59. Coelho, Margarida; Nunes, Patricia; Mendes, Vera M.; Manadas, Bruno; Heerschap, Arend; Jones, John G.. "Effect of Global ATGL Knockout on Murine Fasting Glucose Kinetics". Journal of Diabetes Research (2015): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000358227400001&KeyUID=WOS:000358227400001.
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  61. Duarte, Joao A. G.; Carvalho, Filipa; Pearson, Mackenzie; Horton, Jay D.; Browning, Jeffrey D.; Jones, John G.; Burgess, Shawn C.. "A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice". Journal of Lipid Research 55 12 (2014): 2541-2553.
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  71. Rajpal, Aman; Dube, Simmi; Carvalho, Filipa; Simoes, Ana Rita; Figueiredo, Angelo; Basu, Ananda; Jones, John; Basu, Rita. "Effects of transaldolase exchange on estimates of gluconeogenesis in type 2 diabetes". American Journal of Physiology-Endocrinology and Metabolism 305 4 (2013): E465-E474.
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  75. Delgado, Teresa C.; Barosa, Cristina; Nunes, Patricia M.; Cerdan, Sebastian; Geraldes, Carlos F. G. C.; Jones, John G.. "Resolving the Sources of Plasma Glucose Excursions following a Glucose Tolerance Test in the Rat with Deuterated Water and [U-C-13]Glucose". Plos One 7 3 (2012):
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  79. Reis, C.P.; Neufeld, R.; Veiga, F.; Figueiredo, I.V.; Jones, J.; Soares, A.F.; Nunes, P.; Damgé, C.; Carvalho, R.A.. "Effects of an oral insulin nanoparticle administration on hepatic glucose metabolism assessed by 13C and 2H isotopomer analysis". Journal of Microencapsulation 29 2 (2012): 167-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863418969&partnerID=MN8TOARS.
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  95. Soares, Ana F.; Viega, Francisco J.; Carvalho, Rui A.; Jones, John G.. "Quantifying hepatic glycogen synthesis by direct and indirect pathways in rats under normal ad libitum feeding conditions". Magnetic Resonance in Medicine 61 1 (2008): 1-5. http://dx.doi.org/10.1002/mrm.21830.
    10.1002/mrm.21830
  96. Delgado, T.C.; Barosa, C.; Castro, M.M.C.A.; Geraldes, C.F.G.C.; Bastos, M.; Baptista, C.; Fagulha, A.; et al. "Sources of hepatic glucose production by 2H2O ingestion and Bayesian analysis of 2H glucuronide enrichment". Magnetic Resonance in Medicine 60 3 (2008): 517-523. http://dx.doi.org/10.1002/mrm.21681.
    10.1002/mrm.21681
  97. Jones, John G.; Garcia, Paula; Barosa, Cristina; Delgado, Teresa C.; Caldeira, M. Madalena; Diogo, Luisa. "Quantification of hepatic transaldolase exchange activity and its effects on tracer measurements of indirect pathway flux in humans". Magnetic Resonance in Medicine 59 2 (2008): 423-429. http://dx.doi.org/10.1002/mrm.21451.
    10.1002/mrm.21451
  98. Reis, Catarina P.; Figueiredo, Isabel V.; Carvalho, Rui A.; Jones, John; Nunes, Patricia; Soares, Ana F.; Silva, Cristina F.; et al. "Toxicological assessment of orally delivered nanoparticulate insulin". Nanotoxicology 2 4 (2008): 205-217. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000207480800003&KeyUID=WOS:000207480800003.
    10.1080/17435390802398309
  99. Nunes, P.M.; Carvalho, E.; Jones, J.G.. "Elimination of glucose contamination from adipocyte glycogen extracts". Carbohydrate Research 343 9 (2008): 1486-1489. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449114046&partnerID=MN8TOARS.
    10.1016/j.carres.2008.04.004
  100. Alves, Tiago Cardoso; Nunes, Patrícia Maria; Palmeira, Carlos Marques; Jones, John Griffith; Carvalho, Rui Albuquerque. "Estimating gluconeogenesis by NMR isotopomer distribution analysis of [13C]bicarbonate and [1-13C]lactate". NMR in Biomedicine 21 4 (2007): 337-344. http://dx.doi.org/10.1002/nbm.1195.
    10.1002/nbm.1195
  101. Reis, Catarina Pinto; Veiga, Francisco; Nunes, Patricia; Soares, Ana Francisca; Laranjeira, Tania; Carvalho, Rui; Jones, John; et al. "Toxicological in vivo studies of an oral insulin nanosystern". Toxicology Letters 172 (2007): S90-S90.
    10.1016/j.toxlet.2007.05.250
  102. SENA, CM; BAROSA, C; NUNES, E; SEICA, R; JONES, JG. "Sources of endogenous glucose production in the Goto-Kakizaki diabetic rat". DIABETES & METABOLISM 33 (2007): 296-302.
    10.1016/j.diabet.2007.03.002
  103. Duarte, Iola F.; Goodfellow, Brian J.; Barros, António; Jones, John G.; Barosa, Cristina; Diogo, Luisa; Garcia, Paula; Gil, Ana M.. "Metabolic characterisation of plasma in juveniles with glycogen storage disease type 1a (GSD1a) by high-resolution 1H NMR spectroscopy". NMR in Biomedicine 20 4 (2006): 401-412. http://dx.doi.org/10.1002/nbm.1073.
    10.1002/nbm.1073
  104. Mendes, Ana C.; Caldeira, M. Madalena; Silva, Claudia; Burgess, Shawn C.; Merritt, Matthew E.; Gomes, Filipe; Barosa, Cristina; et al. "Hepatic UDP-glucose 13C isotopomers from [U-13C]glucose: A simple analysis by 13C NMR of urinary menthol glucuronide". Magnetic Resonance in Medicine 56 5 (2006): 1121-1125. http://dx.doi.org/10.1002/mrm.21057.
    10.1002/mrm.21057
  105. Jones, John G.; Fagulha, Ana; Barosa, Cristina; Bastos, Margarida; Barros, Luisa; Baptista, Carla; Caldeira, M. Madalena; Carvalheiro, Manuela. "Noninvasive Analysis of Hepatic Glycogen Kinetics Before and After Breakfast with Deuterated Water and Acetaminophen". Diabetes 55 8 (2006): 2294-2300. http://dx.doi.org/10.2337/db06-0304.
    10.2337/db06-0304
  106. Jones, J.; Barosa, C.; Gomes, F.; Carina Mendes, A.; Delgado, T.; Diogo, L.; Garcia, P.; et al. "NMR Derivatives for quantification of 2H and 13C-enrichment of human glucuronide from metabolic tracers". Journal of Carbohydrate Chemistry 25 2-3 (2006): 203-217. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745133402&partnerID=MN8TOARS.
    10.1080/07328300600732840
  107. Ribeiro, Angela; Caldeira, M. Madalena; Carvalheiro, Manuela; Bastos, Margarida; Baptista, Carla; Fagulha, Ana; Barros, Luisa; Barosa, Cristina; Jones, John G.. "Simple measurement of gluconeogenesis by direct 2H NMR analysis of menthol glucuronide enrichment from 2H2O". Magnetic Resonance in Medicine 54 2 (2005): 429-434. http://dx.doi.org/10.1002/mrm.20567.
    10.1002/mrm.20567
  108. Jin, Eunsook S.; Jones, John G.; Burgess, Shawn C.; Merritt, Matthew E.; Dean Sherry, A.; Malloy, Craig R.. "Comparison of [3,4-13C2]glucose to [6,6-2H2]glucose as a tracer for glucose turnover by nuclear magnetic resonance". Magnetic Resonance in Medicine 53 6 (2005): 1479-1483. http://dx.doi.org/10.1002/mrm.20496.
    10.1002/mrm.20496
  109. Fonseca, C.P.; Jones, J.G.; Carvalho, R.A.; Jeffrey, F.M.H.; Montezinho, L.P.; Geraldes, C.F.G.C.; Castro, M.M.C.A.. "Tricarboxylic acid cycle inhibition by Li+ in the human neuroblastoma SH-SY5Y cell line: A 13C NMR isotopomer analysis". Neurochemistry International 47 6 (2005): 385-393. http://www.scopus.com/inward/record.url?eid=2-s2.0-24144491138&partnerID=MN8TOARS.
    10.1016/j.neuint.2005.06.005
  110. Delgado, T.C.; Tomaz, A.I.; Correia, I.; Costa Pessoa, J.; Jones, J.G.; Geraldes, C.F.G.C.; Castro, M.M.C.A.. "Uptake and metabolic effects of insulin mimetic oxovanadium compounds in human erythrocytes". Journal of Inorganic Biochemistry 99 12 (2005): 2328-2339. http://www.scopus.com/inward/record.url?eid=2-s2.0-28544439916&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2005.08.014
  111. Delgado, Teresa C.; Castro, M. Margarida; Geraldes, Carlos F.; Jones, John G.. "Quantitation of erythrocyte pentose pathway flux with [2-13C]glucose and 1H NMR analysis of the lactate methyl signal". Magnetic Resonance in Medicine 51 6 (2004): 1283-1286. http://dx.doi.org/10.1002/mrm.20096.
    10.1002/mrm.20096
  112. JIN, ES; JONES, JG; MERRITT, M; BURGESS, SC; MALLOY, CR; SHERRY, AD. "Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative". ANALYTICAL BIOCHEMISTRY 327 2 (2004): 149-155.
    10.1006/abio.1998.2796
  113. Perdigoto, Rui; Rodrigues, Tiago B.; Furtado, Alexandre L.; Porto, Armando; Geraldes, Carlos F. G. C.; Jones, John G.. "Integration of [U-13C]glucose and 2H2O for quantification of hepatic glucose production and gluconeogenesis". NMR in Biomedicine 16 4 (2003): 189-198. http://dx.doi.org/10.1002/nbm.826.
    10.1002/nbm.826
  114. Burgess, Shawn C; Weis, Brian; Jones, John G; Smith, Erin; Merritt, Matthew E; Margolis, David; Dean Sherry, A; Malloy, Craig R. "Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine". Analytical Biochemistry 312 2 (2003): 228-234. http://dx.doi.org/10.1016/s0003-2697(02)00465-7.
    10.1016/s0003-2697(02)00465-7
  115. PERDIGOTO, R; FURTADO, AL; PORTO, A; RODRIGUES, TB; GERALDES, CFGC; JONES, JG. "Sources of glucose production in cirrhosis by (H2O)-H-2 ingestion and H-2 NMR analysis of plasma glucose". BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1637 2 (2003): 156-163.
    10.1016/S0925-4439(03)00018-8
  116. Jones, John G.; Perdigoto, Rui; Rodrigues, Tiago B.; Geraldes, Carlos F.G.C.. "Quantitation of absolute 2H enrichment of plasma glucose by 2H NMR analysis of its monoacetone derivative". Magnetic Resonance in Medicine 48 3 (2002): 535-539. http://dx.doi.org/10.1002/mrm.10234.
    10.1002/mrm.10234
  117. Carvalho, Rui A.; Jones, John G.; McGuirk, Chris; Sherry, A. Dean; Malloy, Craig R.. "Hepatic gluconeogenesis and Krebs cycle fluxes in a CCl4 model of acute liver failure". NMR in Biomedicine 15 1 (2002): 45-51. http://dx.doi.org/10.1002/nbm.745.
    10.1002/nbm.745
  118. Burgess, Shawn C.; Carvalho, Rui A.; Merritt, Matthew E.; Jones, John G.; Malloy, Craig R.; Sherry, A.Dean. "13C Isotopomer Analysis of Glutamate by J-Resolved Heteronuclear Single Quantum Coherence Spectroscopy". Analytical Biochemistry 289 2 (2001): 187-195. http://dx.doi.org/10.1006/abio.2000.4930.
    10.1006/abio.2000.4930
  119. Jones, JG; Merritt, M; Malloy, C. "Quantifying tracer levels of (H2O)-H-2 enrichment from microliter amounts of plasma and urine by H-2 NMR". Magnetic Resonance in Medicine 45 1 (2001): 156-158. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000166167400020&KeyUID=WOS:000166167400020.
    10.1002/1522-2594(200101)45:1<156::AID-MRM1020>3.3.CO;2-Q
  120. Jones, JG; Solomon, MA; Cole, SM; Sherry, AD; Malloy, CR; Jones, J.G.; Solomon, M.A.; et al. "An integrated H-2 and C-13 NMR study of gluconeogenesis and TCA cycle flux in humans". American Journal of Physiology-Endocrinology and Metabolism 281 4 (2001): E848-E856. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000171583200025&KeyUID=WOS:000171583200025.
    10.1152/AJPENDO.2001.281.4.E848
  121. Jones, John G.; Carvalho, Rui A.; Sherry, A.Dean; Malloy, Craig R.. "Quantitation of Gluconeogenesis by 2H Nuclear Magnetic Resonance Analysis of Plasma Glucose Following Ingestion of 2H2O". Analytical Biochemistry 277 1 (2000): 121-126. http://dx.doi.org/10.1006/abio.1999.4391.
    10.1006/abio.1999.4391
  122. O'Doherty, RM; Jensen, PB; Anderson, P; Jones, JG; Berman, HK; Kearney, D; Newgard, CB; et al. "Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen". Journal of Clinical Investigation 105 4 (2000): 479-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033995047&partnerID=MN8TOARS.
    10.1172/JCI8673
  123. Jones, John G.; Carvalho, Rui A.; Franco, Byron; Sherry, A.Dean; Malloy, Craig R.. "Measurement of Hepatic Glucose Output, Krebs Cycle, and Gluconeogenic Fluxes by NMR Analysis of a Single Plasma Glucose Sample". Analytical Biochemistry 263 1 (1998): 39-45. http://dx.doi.org/10.1006/abio.1998.2796.
    10.1006/abio.1998.2796
  124. Jones, J.G.; Solomon, M.A.; Dean Sherry, A.; Jeffrey, F.M.H.; Malloy, C.R.; Jones, JG; Solomon, MA; et al. "13C NMR measurements of human gluconeogenic fluxes after ingestion of [U-13C]propionate, phenylacetate, and acetaminophen". American Journal of Physiology - Endocrinology and Metabolism 275 5 38-5 (1998): E843-E852. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032209269&partnerID=MN8TOARS.
    10.1152/AJPENDO.1998.275.5.E843
  125. Jones, John G.; Hansen, Jim; Sherry, A.Dean; Malloy, Craig R.; Victor, Ronald G.. "Determination of Acetyl-CoA Enrichment in Rat Heart and Skeletal Muscle by1H Nuclear Magnetic Resonance Analysis of Glutamate in Tissue Extracts". Analytical Biochemistry 249 2 (1997): 201-206. http://dx.doi.org/10.1006/abio.1997.2172.
    10.1006/abio.1997.2172
  126. Bertocci, L.A.; Jones, J.G.; Malloy, C.R.; Victor, R.G.; Thomas, G.D.; Bertocci, LA; Jones, JG; et al. "Oxidation of lactate and acetate in rat skeletal muscle: Analysis by 13C-nuclear magnetic resonance spectroscopy". Journal of Applied Physiology 83 1 (1997): 32-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030844432&partnerID=MN8TOARS.
    10.1152/JAPPL.1997.83.1.32
  127. Jones, J.G.; Naidoo, R.; Sherry, A.D.; Jeffrey, F.M.H.; Cottam, G.L.; Malloy, C.R.. "Measurement of gluconeogenesis and pyruvate recycling in the rat liver: A simple analysis of glucose and glutamate isotopomers during metabolism of [1,2,3-13C3]propionate". FEBS Letters 412 1 (1997): 131-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030754203&partnerID=MN8TOARS.
    10.1016/S0014-5793(97)00764-3
  128. MALLOY, CR; JONES, JG; JEFFREY, FM; JESSEN, ME; SHERRY, AD. "Contribution of various substrates to total citric acid cycle flux and anaplerosis as determined by C-13 isotopomer analysis and O-2 consumption in the heart". MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE 4 1 (1996): 35-46.
    10.1007/BF01759778
  129. JONES, JG; LE, TH; STOREY, CJ; SHERRY, AD; MALLOY, CR; BURTON, KP. "Effects of different oxidative insults on intermediary metabolism in isolated perfused rat hearts". FREE RADICAL BIOLOGY AND MEDICINE 20 4 (1996): 515-523.
    10.1016/0891-5849(95)02088-8
  130. Jones, J.G.; Cottam, G.L.; Miller, B.C.; Sherry, A.D.; Malloy, C.R.. "A Method for Obtaining 13C Isotopomer Populations in 13C-Enriched Glucose". Analytical Biochemistry 217 1 (1994): 148-152. http://dx.doi.org/10.1006/abio.1994.1095.
    10.1006/abio.1994.1095
  131. BURTON, KP; JONES, JG; LE, TH; SHERRY, AD; MALLOY, CR. "EFFECTS OF OXIDANT EXPOSURE ON SUBSTRATE UTILIZATION AND HIGH-ENERGY PHOSPHATES IN ISOLATED RAT HEARTS". Circulation Research 75 1 (1994): 97-104. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1994NV03100012&KeyUID=WOS:A1994NV03100012.
    10.1161/01.RES.75.1.97
  132. Sherry, A.D.; Sumegi, B.; Miller, B.; Cottam, G.L.; Gavva, S.; Jones, J.G.; Malloy, C.R.; et al. "Orientation-conserved transfer of symmetric krebs cycle intermediates in mammalian tissue". Biochemistry 33 20 (1994): 6268-6275. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028356902&partnerID=MN8TOARS.
    10.1021/bi00186a029
  133. Jones, J.G.; Sherry, A.D.; Jeffrey, F.M.H.; Storey, C.J.; Malloy, C.R.; JONES, JG; SHERRY, AD; et al. "Sources of acetyl-CoA entering the tricarboxylic acid cycle as determined by analysis of succinate 13C isotopomers". Biochemistry 32 45 (1993): 12240-12244. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027359228&partnerID=MN8TOARS.
    10.1021/bi00096a037
  134. JONES, JG; BELLION, E. "METHYLAMINE METABOLISM IN HANSENULA-POLYMORPHA - AN INVIVO C-13 AND P-31 NUCLEAR-MAGNETIC-RESONANCE STUDY". JOURNAL OF BACTERIOLOGY 173 16 (1991): 4959-4969. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991GB01400007&KeyUID=WOS:A1991GB01400007.
    10.1128/JB.173.16.4959-4969.1991
  135. JONES, JG; BELLION, E. "METHANOL OXIDATION AND ASSIMILATION IN HANSENULA-POLYMORPHA - AN ANALYSIS BY C-13 NMR INVIVO". BIOCHEMICAL JOURNAL 280 (1991): 475-481. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991GU90100031&KeyUID=WOS:A1991GU90100031.
    10.1042/BJ2800475
  136. JONES, JG; BELLION, E. "INVIVO C-13 AND N-15 NMR-STUDIES OF METHYLAMINE METABOLISM IN PSEUDOMONAS SPECIES MA". JOURNAL OF BIOLOGICAL CHEMISTRY 266 18 (1991): 11705-11713. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991FT76200046&KeyUID=WOS:A1991FT76200046.

Intellectual property

Patent
  1. Jones, John. 2011. "Methods of Distinguishing Between Glutamine Formed by Cataplerosis or Proteolysis". United States.
  2. Jones, John. 2007. "Measurements of gluconeogenesis and intermediary metabolism using stable isotopes".
  3. Jones, John. 2001. "Methods for determining gluconeogenesis, anapleurosis and pyruvate recycling". United States.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/10/01 - Current The role of exogenous and endogenous fructose turnover in adipose tissue dysfunction during the development of Type 2 Diabetes
Supervisor
2022/10/01 - Current Development of a zebrafish model for high-resolution analyses of lipogenic fluxes in non-alcoholic fatty liver disease
Supervisor
2017/10/01 - 2022/12/10 Multiomic approaches for thyroid cancer diagnosis
Supervisor
2017/10/01 - 2022/01/14 Fructose metabolism and lipogenesis fluxes in mice models of diet-induced non-alcoholic fatty liver disease
Supervisor
2017/10 - 2021/11/06 Tracing hepatic glycogen metabolism with stable isotope tracers - insights from murine studies
Supervisor
2019/09/01 - 2021/02/01 The effects of high fat feeding on the metabolomics of heart, kidney and skeletal muscle in C57BL6J mice as analysed by 1H NMR
Supervisor
2014/10/01 - 2020/05/12 Sugar, intestine & metabolic syndrome - high fructose feeding and hepatic fatty liver disease inflammation: the role of intestinal microbiota
Supervisor
2018/09/01 - 2020/02/01 NMR analysis of urinary acetaminophen glucuronide enrichments from 2H and 13C metabolic tracers in mouse models
Supervisor
2018/09/01 - 2020/02/01 The impact of different lipogenic diets on direct and indirect pathway contributions to hepatic glycogen synthesis
Supervisor
2016/09/01 - 2018/02/01 13C NMR analysis of triglyceride fatty acid enrichment from 13C-enriched lipogenic substrates
Supervisor
2013/09/01 - 2015/02/01 Ketone bodies as brain substrates
Supervisor
2013/09/01 - 2015/02/01 Quantifying triglyceride futile cycling with deuterated water and 2H NMR analysis of glycerol 2H enrichment
Supervisor
2010/10/01 - 2014/12/02 Brain-liver Nitric oxide – A Major Player in Insulin Clearance and Actions
2012/09/01 - 2013/10/01 Quantifying the effects of high fructose feeding on the intestinal permeability of endotoxins
Supervisor
2008/10/01 - 2012/11/12 Sources of Blood Glucose and Liver Glycogen in the Seabass: Implications for Carbohydrate Metabolism in Fish
2007/10/01 - 2012/01/20 Noninvasive Measurements of Human Hepatic Metabolism Using Deuterated Water
2007/01/01 - 2011/06/15 Profiling the control of hepatic glucose and lipid metabolism for evaluating novel strategies of insulin delivery
2005/10 - 2009/03 Insulin Resistance & Diabetes: Insights from Magnetic Resonance Studies of Hepatic Glucose & Lipid Metabolism

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/05/09 - 2019/05/10 EASD-EGIR meeting in Lisbon (2019/05/09 - 2019/05/10)
Conference (Co-organisor)
2019/05/08 - 2019/05/09 EASD-NAFLD meeting in Lisbon (2019/05/08 - 2019/05/09)
Conference (Co-organisor)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/12/05 - 2022/12/06 International Diabetes Federation Biennial Meeting Invited lecture: “Role of high sugar and high fat feeding on lipid overflow” Biennial Meeting
2022/09/22 - 2022/09/23 European Association for the Study of Diabetes (EASD) 58th Annual meeting. invited lecture ¿Exogenous fructose and glucose as precursors for hepatic de novo synthesis of lipotoxic fatty acids¿
Conference
 European Association for the Study of Diabetes (EASD) annual meeting
2019/12/06 - 2019/12/07 International Diabetes Federation Biennial Meeting invited lecture "“The role of the microbiome in perturbing the gut-brain axis during high sugar and fat feeding”
Conference
 International Diabetes Federation Biennial Meeting
2017/12/08 - 2017/12/09 International Diabetes Federation Biennial Meeting invited lecture “Metabolic flux profiling of non-alcoholic fatty liver disease”
Conference
 International Diabetes Federation Biennial Meeting
2017/05/16 - 2017/05/17 Departmental seminar, Francis Crick Institute, “Metabolic studies in different organisms using deuterated water tracer”
Seminar
 Departmental Seminar
2017/03/04 - 2017/03/05 Departmental seminar CEDOC, New University of Lisbon "“Metabolic studies in different organisms using deuterated water tracer”
Seminar
 Departmental Seminar
2015/09/16 - 2015/09/17 European Association for the Study of Diabetes (EASD) 51st meeting. Symposium: The Liver in Focus, “Hepatic glucose and lipid metabolism”
Conference
 Symposium: The Liver in Focus, “Hepatic glucose and lipid metabolism”
2014/10/20 - 2014/10/21 Departmental seminar, Institute of Physiology, Czech Republic “Studies of metabolism using deuterated water and 2H NMR”
Seminar
 Departmental Seminar
2012/09/02 - 2012/09/03 IV Ibero-American NMR Meeting invited lecture “Studies of metabolism with deuterated water and 2H NMR”
Conference
 IV Ibero-American NMR Meeting
2011/11/12 - 2011/11/13 Departmental seminar, German Diabetes Center, “Novel approaches for assessing metabolic regulation in diabetes”
Seminar
 Departmental seminar, German Diabetes Center
2011/09/13 - 2011/09/14 Glycosciences in the International Year of Chemistry invited lecture “Effects and implications of transaldolase activity on glucose flux measurements in humans”
Conference
 Glycosciences in the International Year of Chemistry
2008/09/12 - 2008/09/13 5th Iberian Spectroscopy Meeting invited lecture “Non-invasive studies of liver metabolism in humans by stable isotope tracers and NMR”
Conference
 5th Iberian Spectroscopy Meeting
2008/09/06 - 2008/09/07 GLUPOR 8 meeting invited lecture “Liver carbohydrate metabolism in humans using stable isotope tracers and NMR.”
Conference
 GLUPOR 8 meeting
2008/09/02 - 2008/09/03 4th Iberian Carbohydrate meeting invited lecture “Studies of carbohydrate metabolism in humans by stable isotope tracers and NMR”
Conference
 4th Iberian Carbohydrate meeting
2007/09/05 - 2007/09/06 GLUPOR 7 meeting invited lecture “Studies of carbohydrate metabolism in humans by stable isotope tracers and NMR.”
Conference
 GLUPOR 7 meeting
2003/12/05 - 2003/12/06 University of Algarve Biochemistry Department Departmental seminar “Non-invasive studies of glucose metabolism in humans”
Seminar
 Departmental Seminar

Association member

Society Organization name Role
2005/03/01 - Current Portuguese Society of Diabetology Head of the Group for Fundamental and Translational Investigation (GIFT) from 2017-2023
2005/01/01 - Current European Association for the Study of Diabetes

Committee member

Activity description
Role 		Institution / Organization
2017/03/01 - 2023/03/15 Coordinator of the Group for Fundamental and Translational Investiagtion (GIFT) Study group for the Portuguese Society for Diabetology from 2017-2023
Coordinator
2017/05/06 - 2021/05/15 Board member for the European Association for the Study of Diabetes Insulin Resistance Study group
Member

Mentoring / Tutoring

Topic Student name
2015/01/01 - Current Mentoring of FCT and DL57 Postdoctoral Fellowship and Contract Cristina Barosa
2022/03/01 - 2022/07/01 Monteclimar fellowship for visiting students Ivonne Palacios Marin
2021/10/01 - 2021/12/15 ERASMUS Student Exchange Fellowship Charlotte Kahm
2018/01/01 - 2021/03/01 NMR studies of fructose metabolism in animal models Ludgero Canário Tavares
2019/04/01 - 2019/06/30 Secondment of Student in the Marie Curie Training Network TREATMENT Dora Koller
2019/03/01 - 2019/05/01 Secondment of Student in the Marie Curie Training Network FOIE GRAS Sara Guerra
2013/01/01 - 2017/12/31 Developing stable isotope tracer studies in fish Ivan Viegas
2014/03/01 - 2014/05/31 Visiting EFSD Albert Renold Travel Fellowship Petr Zouhar
2009/01/01 - 2012/06/06 NMR studies of metabolism Teresa Cardoso Delgado
Distinctions

Award

2008 GSK IdeaSpring Prize, Most Promising Innovative Technology
2005 Portuguese Society of Diabetes-JABA Industry Hargreaves Prize, Best Research Study on Diabetes in Portugal in 2004