Joana Patrícia Mota Guerreiro (B91A-9DCD-63AF)

Curriculum Vitae

Joana Patrícia Mota Guerreiro. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Sementes lupinus; MMP-9; doenças inflamatórias intestino; alimentos funcionais; .

Identification

Personal identification

Full name: Joana Patrícia Mota Guerreiro

Citation names

Mota, Joana
Mota, J.

Author identifiers

Ciência ID: B91A-9DCD-63AF
ORCID iD: 0000-0002-8835-852X

Education

	Degree	Classification
2018 - 2023 Concluded	Biologia (Doutoramento) Major in Engenharia Alimentar e Bioquímica Universidade de Lisboa Instituto Superior de Agronomia, Portugal	Distinção e Louvor
2016 Concluded	Bioquímica para a Saúde (Mestrado) Major in Sem especialização Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal "Deflamin bioactivities - A novel inhibitory protein of MMP-9 from Lupinus albus" (THESIS/DISSERTATION)	18 valores
2014 Concluded	Biologia (Licenciatura) Universidade de Lisboa Instituto Superior de Agronomia, Portugal	16

Projects

Contract

	Designation	Funders
2022/01/01 - 2024/12/31	Desenvolvimento de bebidas vegetais de tremoço e grão como alimento funcional para o cancro colorectal PTDC/OCE-ETA/4836/2021 Universidade de Lisboa Instituto Superior de Agronomia, Portugal Universidade de Lisboa Centro de Investigação em Agronomia Alimentos Ambiente e Paisagem, Portugal Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/09 - 2022/09	Potential of antibacterial bioactivities against mastitis in milk obtained from dairy cattle fed with Opuntia ficus-indica OP-FEED&FOOD Researcher Universidade Lusófona de Humanidades e Tecnologias Faculdade de Medicina Veterinária, Portugal	Ongoing
2021/09 - 2022/09	Desenvolvimento de novas terapias nutrace^uticas para tratamento de osteoartrite utilizando o cavalo como modelo natural da doenc¸a OSTEOHEALTH Researcher Universidade Lusófona de Humanidades e Tecnologias Faculdade de Medicina Veterinária, Portugal
2021/09 - 2022/09	Using an extract from legume seeds to prevent post-weaning diarrhea in piglets Lupine4Weaning Researcher Universidade Lusófona de Humanidades e Tecnologias Faculdade de Medicina Veterinária, Portugal
2021/09 - 2022/09	Bioactivities of fermented whey enriched with antibacterial and anti-inflammatory peptides as a way towards a healthier gut microbiome and a healthier life WHEY2HEALTH Researcher Universidade de Lisboa Instituto Superior de Agronomia, Portugal
2018/01/01 - 2021/12/31	Ludexin, an edible anti-inflammatory and anticancer protein isolated from legume seeds SFRH/BD/132832/2017 Universidade de Lisboa Instituto Superior de Agronomia, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/09/01 - 2021/08/31	Atividades anti-inflamatórias e anticancerígenas de uma proteína isolada de sementes de Lupinus e a sua aplicação em alimentos funcionais PTDC/BAA-AGR/28608/2017 Universidade de Lisboa Instituto Superior de Agronomia, Portugal	Fundação para a Ciência e a Tecnologia Ongoing

Outputs

Publications

Conference abstract	Mota, Joana (B91A-9DCD-63AF); Lima, A.I.G.; Ferreira, Ricardo Boavida; Bischoff, Nicholas; Silva, M.J.; Ventura, C; Louro, H. "Safety assessment of the new bioactive compound deflamin, extracted from Lupinus albus seeds, through the analysis of its cytotoxic and genotoxic properties.". Paper presented in 4th International Congress on Environmental Health, Lisboa, 2019. Accepted
Conference poster	"Emerging new possibilities on bioactive whey peptides: extended fermentation produces a novel casein-derived peptide with broad-range antibacterial activities that also inhibits MMP-2 and MMP-9.". Paper presented in Encontro Ciência 2021, 2021. "Lupin Seed Protein Extract Can Enrich the Physical Properties of Cookies Prepared with Alternative Flours". Paper presented in Encontro Ciência 2021, 2021. "New alternatives to milk from pulses: digestibility and bioactivity.". Paper presented in Encontro Ciência 2021, 2021. "Anti-inflammatory and anticancer activities of a protein isolated from Lupinus seeds and its application in functional foods.". Paper presented in Encontro Ciência 2021, 2021. "New alternatives to milk from pulses: digestibility and bioactivity". Paper presented in Agri-Food Ecosystem, 2021. Alvim, M. C.; Mota, Joana (B91A-9DCD-63AF); Martins, J.N.; Ferreira, Ricardo Boavida; Lima, A.I.G.. "Anti-inflammatory potential of Lupinus Mutabilis seeds: isolation of deflamin, a polypeptide with a potente inhibitory effect on MMP-9 activities". Paper presented in XV International Lupin Conference, 2019. Sousa, C; Mota, Joana (B91A-9DCD-63AF); Martins, J.N.; Ferreira, Ricardo Boavida; Lima, A.I.G.. "Deflamin isolated from Lupinus mutabilis seeds inhibits colon cancer cell invasion.". Paper presented in XV International Lupin Conference, 2019.
Journal article	Sara Miguel Silva; Ana Cláudia Martins Cavaco; Bianca Basso; Joana Mota; Raquel Duarte; Miguel Costa; Luis Costa; et al. "Therapeutic Potential of Deflamin against Colorectal Cancer Development and Progression". Cancers (2022): https://www.mdpi.com/2072-6694/14/24/6182. 10.3390/cancers14246182 Joana Mota; Sandra Casimiro; João Carlos Fernandes; Renata M. Hartmann; Elizângela Schemitt; Jaqueline Picada; Luis Costa; et al. "Lupin Protein Concentrate as a Novel Functional Food Additive That Can Reduce Colitis-Induced Inflammation and Oxidative Stress". Nutrients (2022): https://www.mdpi.com/2072-6643/14/10/2102. 10.3390/nu14102102 Joana Mota; Joao Rocha; João Fernandes; Bruno Sepodes; Figueira, ME; A. Raymundo; Ana Lima; Ricardo Boavida Ferreira. "Lupinus albus Protein Components Inhibit MMP-2 and MMP-9 Gelatinolytic Activity In Vitro and In Vivo". International Journal of Molecular Sciences (2021): https://www.mdpi.com/1422-0067/22/24/13286. 10.3390/ijms222413286 Maria Isabel Santos; Ana Lima; Joana Mota; Patrícia Rebelo; Ricardo Boavida Ferreira; Laurentina Pedroso; Maria Adélia Ferreira; Isabel Sousa. "Extended Cheese Whey Fermentation Produces a Novel Casein-Derived Antibacterial Polypeptide That Also Inhibits Gelatinases MMP-2 and MMP-9". International Journal of Molecular Sciences (2021): https://www.mdpi.com/1422-0067/22/20/11130. 10.3390/ijms222011130 Joana Mota; Ana Lima; Ricardo Boavida Ferreira; A. Raymundo. "Technological Potential of a Lupin Protein Concentrate as a Nutraceutical Delivery System in Baked Cookies". Foods (2021): https://www.mdpi.com/2304-8158/10/8/1929. 10.3390/foods10081929 Joana Mota; Figueira, ME; Ricardo Boavida Ferreira; Ana Lima. "An Up-Scalable and Cost-Effective Methodology for Isolating a Polypeptide Matrix Metalloproteinase-9 Inhibitor from Lupinus albus Seeds". Foods (2021): https://www.mdpi.com/2304-8158/10/7/1663. 10.3390/foods10071663 Carla Graça; Joana Mota; Ana Lima; Ricardo Boavida Ferreira; A. Raymundo; Isabel Sousa. "Glycemic Response and Bioactive Properties of Gluten-Free Bread with Yoghurt or Curd-Cheese Addition". Foods (2020): https://www.mdpi.com/2304-8158/9/10/1410. 10.3390/foods9101410 Mota, Joana; Lima, Ana; Ferreira, Ricardo Boavida; Raymundo, Anabela. "Lupin Seed Protein Extract Can Efficiently Enrich the Physical Properties of Cookies Prepared with Alternative Flours". Foods 9 8 (2020): 1064-1064. http://dx.doi.org/10.3390/foods9081064. 10.3390/foods9081064 Rocha, João; Direito, Rosa; Lima, Ana; Mota, Joana; Gonçalves, Margarida; Duarte, Maria Paula; Solas, João; et al. "Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice". Biomedicine & Pharmacotherapy 118 (2019): 109351. http://dx.doi.org/10.1016/j.biopha.2019.109351. Accepted • 10.1016/j.biopha.2019.109351 Direito, Rosa; Lima, Ana; Rocha, João; Ferreira, Ricardo Boavida; Mota, Joana; Rebelo, Patrícia; Fernandes, Adelaide; et al. "Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities". The Journal of Nutritional Biochemistry 46 (2017): 100-108. http://dx.doi.org/10.1016/j.jnutbio.2017.03.002. Accepted • 10.1016/j.jnutbio.2017.03.002 Lima, Ana; Oliveira, Jennifer; Saúde, Filipe; Mota, Joana; Ferreira, Ricardo. "Proteins in Soy Might Have a Higher Role in Cancer Prevention than Previously Expected: Soybean Protein Fractions Are More Effective MMP-9 Inhibitors Than Non-Protein Fractions, Even in Cooked Seeds". Nutrients 9 3 (2017): 201. http://dx.doi.org/10.3390/nu9030201. Accepted • 10.3390/nu9030201 Lima, A.I.G.; Mota, J.; Monteiro, S.A.V.S.; Ferreira, R.M.S.B.. "Legume seeds and colorectal cancer revisited: Protease inhibitors reduce MMP-9 activity and colon cancer cell migration". Food Chemistry 197 (2016): 30-38. http://dx.doi.org/10.1016/j.foodchem.2015.10.063. Accepted • 10.1016/j.foodchem.2015.10.063

Intellectual property

Patent

Mota, Joana (B91A-9DCD-63AF); Lima, A.I.G.; Ferreira, Ricardo Boavida. 2017. "DEFLAMIN: Therapeutic protein".
Granted/Issued

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2019/11/12	Deflamin, an edible anti-inflammatory protein isolated from lupin seeds.	World Summit on Advancement in Food Science and Technology (Valência, Spain)
2019/09/21	Deflamin, a non-toxic oligomer from lupinus albus seeds, resists digestion and inhibits colitis by targeting mmp-9 activity in vitro and in vivo	World Congress of Gastroenterology (Istambul, Turkey)
2018/09/26	Deflamin, an edible anti-inflammatory protein isolated from legume seeds.	2nd International Conference on Food Bioactives & Health (Lisboa, Portugal)

Event organisation

	Event name Type of event (Role)	Institution / Organization
2021/11/19 - 2021/11/19	I Webinar, One Health Day, Antimicrobial Awareness Week, A importância dos Antimicrobianos na era One Health (2021/11/19 - 2021/11/19) Conference (Member of the Organising Committee)	Universidade Lusófona de Humanidades e Tecnologias Faculdade de Medicina Veterinária, Portugal

Distinctions

Award

2018	Born From Knowledge - Deflamin, a protein present in a lupin preparation with bioactivities for health and well-being. Agência Nacional de Inovação SA, Portugal