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I completed my BSc in Biochemistry in 2016 and my MSc in Health Sciences in 2018 at the University of Minho, Braga, Portugal. During my undergraduate training period, I was involved in a project focused on metabolic alterations in Acute Myeloid Leukemia cell lines, at the Life and Health Sciences Research Institute (ICVS) under the supervision of Prof. Paula Ludovico. My MSc work was conducted at ICVS under the supervision of Dr. Sara Granja and Prof. Fátima Baltazar, and it was focused on the development of a novel therapeutic tool based on nanosystems to specifically target both glycolysis and OXPHOS pathways in the context of lung cancer. In 2019, I was awarded with a PhD fellowship from the Foundation of Science and Technology (FCT) to pursue my research in the field of onco-immunology. During the first two years of my PhD in Health Sciences, I was at the ICVS research institute developing a project that aimed to shed light on the biological mechanisms in which CD147 promotes an immunosuppressive tumor microenvironment and resistance to immunotherapy. In the last two years, I moved to Belgium to do part of my PhD at the Laboratory of Tumor Inflammation and Angiogenesis (VIB - KU Leuven, Center for Cancer Biology). I had the opportunity to work on two projects, under the supervision of Massimiliano Mazzone, that aimed to determine the effect of genetic targeting and pharmacological inhibition of macrophage Glud1 in cancer and Duchenne Muscular Dystrophy. Currently, I'm in Portugal finishing my PhD thesis. During my academic path, I had the opportunity to materialize my scientific activity by authoring original and review articles as well as a book chapter, and presenting 1st-authorship posters at five different international congresses. Moreover, I have greatly expanded my knowledge of technical skills in cancer biology, namely, in cell culture (cell transfection, metabolism, viability, proliferation, migration, invasion), molecular biology (Western blot, immunofluorescence, immunohistochemistry, immunoprecipitation, RT-qPCR and Flow cytometry), and in animal experimentation (mice - handling; restraining, body weight and tumor measurement; bone marrow and lymph node isolation; organ, tumor and muscle excision and intraperitoneal, intratracheal, subcutaneous and orthotopic mammary fat pad injections).
Identification

Personal identification

Full name
Andreia Nunes

Citation names

  • Pereira-Nunes, Andreia

Author identifiers

Ciência ID
BA11-FDEE-4EC0
ORCID iD
0000-0002-7890-9228

Email addresses

  • id8806@alunos.uminho.pt (Professional)

Addresses

  • Instituto de Investigação em Ciências da Vida e Saúde (ICVS), Campus de Gualtar, Universidade do Minho , 4710-057 , Gualtar, Braga, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Advanced (C1) Upper intermediate (B2) Upper intermediate (B2)
French Elementary (A2) Intermediate (B1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2019/09/01 - 2023/10/31
Ongoing
Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Vlaams Instituut voor Biotechnologie KU Leuven Center for Cancer Biology, Belgium
"Targeting CD147- and Glud1-mediated metabolic reprograming in cancer and muscular dystrophy" (THESIS/DISSERTATION)
2016/09/01 - 2018/10/29
Concluded
Health Sciences (Mestrado)
Major in Health Sciences
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
"Targeting cancer cell metabolism using targeted-drug delivery systems" (THESIS/DISSERTATION)
18
2013/09/01 - 2016/07/11
Concluded
Bioquímica (Licenciatura)
Major in Biochemistry
Universidade do Minho Escola de Ciências, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
"Metabolic Alterations in Acute Myeloid Leukemia Cell Lines" (THESIS/DISSERTATION)
16
Affiliation

Science

Category
Host institution
Employer
2019/09/01 - 2023/10/31 Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
(...)

Others

Category
Host institution
Employer
2018/11/01 - 2019/07/12 Volunteer Internship Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Escola de Medicina, Portugal
(...)
2016/11/01 - 2018/10/29 Master's Student Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Escola de Medicina, Portugal
(...)
Projects

Contract

Designation Funders
2019/09/01 - 2023/10/31 CD147 in cancer immunosurveillance: new tool for T-cell based immunotherapy?
SFRH/BD/148476/2019
PhD Student Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/09/01 - 2023/06/30 Genetic targeting and pharmacological inhibition of macrophage-specific GLUD1 as potential treatment option for muscular dystrophy
N/A
PhD Student Fellow
Vlaams Instituut voor Biotechnologie KU Leuven Center for Cancer Biology, Belgium
Concluded
2021/07/01 - 2023/06/30 GLUD1 as a potential target for cancer therapy
N/A
PhD Student Fellow
Vlaams Instituut voor Biotechnologie KU Leuven Center for Cancer Biology, Belgium
Concluded

Other

Designation Funders
2017/04/01 - 2018/10/29 Targeting cancer cell metabolism using targeted-drug delivery systems (Master's student)
N/A
Other
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Concluded
Outputs

Publications

Book chapter
  1. Pereira-Nunes, Andreia; Afonso, Julieta; Granja, Sara; Baltazar, Fátima. "Lactate and Lactate Transporters as Key Players in the Maintenance of the Warburg Effect". In Advances in Experimental Medicine and Biology, 51-74. Springer International Publishing, 2020.
    Published • 10.1007/978-3-030-34025-4_3
Conference poster
  1. Ammarah, Ummi; Pereira-Nunes, Andreia; Shang, Min; Di Matteo, Mario; Granja, Sara; Baltazar, Fátima; Mazzone, Massimiliano. "Targeting macrophage GLUD1 inhibits metachronous and synchronous metastases. Recent insights into Immuno-Oncology". Paper presented in VIB Conference Series: "Recent insights into Immuno-Oncology", 2022.
  2. Pereira-Nunes, Andreia; Santos, Nuno; Baltazar, Fátima; Granja, Sara. "CD147 in cancer immunosurveillance: new-tool for T-cell based immunotherapy?". Paper presented in EACR 2021 Congress: "Innovative Cancer Science: Better Outcomes through Research", 2021.
  3. Pereira-Nunes, Andreia; Ferreira, Helena; Neves, Nuno M.; Baltazar, Fátima; Granja, Sara. "Disruption of cancer cell metabolism using targeted-drug delivery systems". Paper presented in Virtual Conference: "Cancer Biology: From Basic to Translational Research", 2020.
  4. Pereira-Nunes, Andreia; Santos, Nuno; Costa, Sandra; Baltazar, Fátima; Granja, Sara. "Lactate transporters as targets to improve immunotherapy". Paper presented in EACR-AACR-ASPIC 2020 Conference: "Tumor Microenvironment", 2020.
  5. Pereira-Nunes, Andreia; Ferreira, Helena; Neves, Nuno M.; Baltazar, Fátima; Granja, Sara. "Disruption of cancer cell metabolism using targeted-drug delivery systems". Paper presented in 6th Annual Meeting of of the International Society of Cancer Metabolism (ISCaM) 2019 - "Cancer Metabolic Rewiring: Mapping the Road to Clinical Translation", 2019.
  6. Pereira-Nunes, Andreia; Ferreira, Helena; Neves, Nuno M.; Baltazar, Fátima; Granja, Sara. "Targeting cancer cell metabolism using targeted-drug delivery systems". Paper presented in 26th Porto Cancer Meeting: "The Cancer Ecosystem", 2019.
  7. Pereira-Nunes, Andreia; Ferreira, Helena; Neves, Nuno M.; Baltazar, Fátima; Granja, Sara. "Targeting cancer cell metabolism using targeted drug-delivery systems". Paper presented in ICVS Open Day 2019, 2019.
  8. Pereira-Nunes, Andreia; Ferreira, Helena; Neves, Nuno M.; Baltazar, Fátima; Granja, Sara. "Targeting cancer cell metabolism using targeted-drug delivery systems". Paper presented in 25th Porto Cancer Meeting: "Cancer Wars: The Immune Force Awakens", 2018.
  9. Pereira-Nunes, Andreia; Ferreira, Helena; Neves, Nuno M.; Baltazar, Fátima; Granja, Sara. "Targeting cancer cell metabolism using targeted-drug delivery systems". Paper presented in ICVS Open Day 2018, 2018.
Journal article
  1. Ammarah, Ummi; Pereira-Nunes, Andreia; Delfini, Marcello; Mazzone, Massimiliano. "From monocyte-derived macrophages to resident macrophages - how metabolism leads their way in cancer". Molecular Oncology (2024): http://dx.doi.org/10.1002/1878-0261.13618.
    Published • 10.1002/1878-0261.13618
  2. Pereira-Nunes, Andreia; Ferreira, Helena; Abreu, Sara; Guedes, Marta; Neves, Nuno M.; Baltazar, Fátima; Granja, Sara. "Combination Therapy With CD147-Targeted Nanoparticles Carrying Phenformin Decreases Lung Cancer Growth". Advanced Biology 7 7 (2023): http://dx.doi.org/10.1002/adbi.202300080.
    Published • 10.1002/adbi.202300080
  3. Pereira-Nunes, Andreia; Simões-Sousa, Susana; Pinheiro, Céline; Miranda-Gonçalves, Vera; Granja, Sara; Baltazar, Fátima. "Targeting lactate production and efflux in prostate cancer". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 11 (2020): 165894. http://dx.doi.org/10.1016/j.bbadis.2020.165894.
    Open access • Published • 10.1016/j.bbadis.2020.165894
  4. Santos, Nuno; Pereira-Nunes, Andreia; Baltazar, Fátima; Granja, Sara. "Lactate as a Regulator of Cancer Inflammation and Immunity". Immunometabolism 1 (2019): e190015. http://dx.doi.org/10.20900/immunometab20190015.
    Open access • Published • 10.20900/immunometab20190015
Thesis / Dissertation
  1. Pereira-Nunes, Andreia. "Targeting cancer cell metabolism using targeted drug-delivery systems". Master, Universidade do Minho, 2018.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/01/01 Laboratory rotation: "Unravel the role of lactate receptor GPR81 in lung cancer". Supervision: Sara Granja and Fátima Baltazar
2017/02/13 Laboratory rotation: "Interaction between macrophages and tumor cells in lung cancer". Supervision: Sara Granja and Sandra Costa.
2016/11/01 Laboratory rotation: "Immunological aging as a trigger for Multiple Sclerosis". Supervision: Cláudia Nobrega and João Gomes.

Event participation

Activity description
Type of event
Event name
Institution / Organization
2023/02/09 - 2023/02/10 Tracer metabolomics course
Vlaams Instituut voor Biotechnologie KU Leuven Center for Cancer Biology, Belgium
2022/06/06 - 2022/06/17 Participation in Recent insights into Immuno-Oncology. This conference provided new insights into the immune response to tumors and the improvements in immune checkpoint therapies.
Conference
Recent insights into Immuno-Oncology
Vlaams Instituut voor Biotechnologie KU Leuven Center for Cancer Biology, Belgium
2022/05/16 - 2022/06/03 Immunometabolism: from basics to therapy
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021/06/09 - 2021/06/12 Participation in the EACR 2021 Virtual Congress: Innovative Cancer Science. This event highlighted the latest basic, preclinical and translational cancer research across a wide breadth of topics.
Congress
EACR 2021 Virtual Congress: Innovative Cancer Science
European Association For Cancer Research, United Kingdom
2020/09/25 - 2020/09/25 Participation in the Webinar: Cancer Biology: From Basic to Translational Research. This conference aimed to present the most promising results in the area of oncology that may have an impact a clinical impact.
Liga Portuguesa Contra o Cancro, Portugal
2020/03/02 - 2020/03/04 Participation in the EACR-AACR-ASPIC 2020 Conference in Lisbon. This event aimed to discuss the current state of the tumor microenvironment (TME) field and to share effective therapeutic approaches targeting the TME for long-term management of disease.
Congress
EACR-AACR-ASPIC 2020 Conference: Tumor Microenvironment
European Association For Cancer Research, United Kingdom

American Association for Cancer Research, United States
2019/10/17 - 2019/10/19 Participation in the 6th Annual Meeting of the International Society of Cancer Metabolism (ISCaM) 2019 in Braga. This congress tackled the many faces of cancer metabolism, highlighted the recent advances in the field and the road ahead for clinical translation.
Congress
6th Annual Meeting of the International Society of Cancer Metabolism (ISCaM) 2019
Universidade do Minho Escola de Ciências, Portugal

Universidade do Minho Escola de Medicina, Portugal

Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/10/03 - 2019/10/03 This workshop seminar organized by Elsevier Researcher Academy was focused on: (i) how to write great papers and get published; (ii) understanding and benefiting from the publishing process.
Workshop
How to Write a Great Research Paper, and Get it Accepted by a Good Journal
Universidade do Minho, Portugal

Universidade do Minho Escola de Ciências, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/05/02 - 2019/05/03 Participation in the 26th Porto Cancer Meeting in Porto. This event aimed to share knowledge on the latest developments on the cancer ecosystem and discuss its pivotal role on the modulation of tumor development, diagnosis and treatment.
Congress
26th Porto Cancer Meeting: "The Cancer Ecosystem"
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/04/06 - 2019/04/06 Participation in the ICVS Open Day 2019 in Braga.
Meeting
ICVS Open Day 2019
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/01/16 - 2019/01/18 Participation in the nanoGateway Winter School 2019 in Braga. This initiative aimed to share knowledge on therapy and diagnostic applications of nanotechnology and in medical context.
Conference
nanoGateway Winter School 2019: "Nanotechnology for Therapy and Diagnostics"
International Iberian Nanotechnology Laboratory, Portugal
2018/04/26 - 2018/04/27 Participation in the 25th Porto Cancer Meeting in Porto. This event aimed to discuss the latest developments in Immuno-Oncology as a crucial means for developing the best possible therapies for cancer patients.
Congress
25th Porto Cancer Meeting: "Cancer Wars: The Immune Force Awakens"
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/04/06 - 2018/04/06 Participation in the ICVS Open Day 2018 in Braga.
Meeting
ICVS Open Day 2018
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/03/13 - 2017/03/31 Cell functional and phenotypical analysis: the usefulness of flow cytometry and related tools
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/01/30 - 2017/02/10 Laboratory Animal Sciences
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/11/14 - 2016/11/17 Course structure of the forming unit (643/CEPS/2016): Basic principles in first aid; basic life support; external automatic defibrillation; bleeding, bruising and burns; injuries to the head, neck, back, bones, muscles or joints; and intoxications, precordial pain and stroke.
Workshop
First Aid Course
Universidade do Minho, Portugal
2016/04/06 - 2016/04/06 Workshop of clinical microbiology and infection.
Workshop
Microbiologia Clínica e Infeção
Universidade do Minho Escola de Medicina, Portugal
2016/04/05 - 2016/04/06 Participation in the VII Biochemistry Journeys in Braga.
Conference
VII Jornadas de Bioquímica: "Ciência para a vida"
Universidade do Minho, Portugal

Universidade do Minho Escola de Ciências, Portugal
2016/02/25 - 2016/02/25 Workshop of scientific writing techniques.
Workshop
Técnicas de Escrita Científica
Universidade do Minho, Portugal

Universidade do Minho Escola de Ciências, Portugal
2015/04/21 - 2015/04/22 Participation in the VI Biochemistry Journeys in Braga.
Conference
VI Jornadas de Bioquímica: "Aventuras do Conhecimento"
Universidade do Minho, Portugal

Universidade do Minho Escola de Ciências, Portugal

Mentoring / Tutoring

Topic Student name
2018/05/01 - 2018/06/15 Part of Patricia's master thesis Patrícia Correia
2017/11/01 - 2018/01/01 Laboratory Rotation Joana Mendes
Distinctions

Award

2019 PhD scholarship
Fundação para a Ciência e a Tecnologia, Portugal