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Lígia Vanessa Rocha Fão. Concluiu o(a) Mestrado em Mestrado Integrado em Engenharia Biomédica - Especialização em Neurociências em 2016 pelo(a) Universidade de Coimbra Faculdade de Ciencias e Tecnologia. É Investigador no(a) Universidade de Coimbra Centro de Neurociências e Biologia Celular, PhD student - Doctoral Programme in Health Sciences - University of Coimbra no(a) Universidade de Coimbra Faculdade de Medicina e PhD Student - Doctoral Programme in Health Sciences no(a) Universidade de Coimbra Faculdade de Medicina.
Identification

Personal identification

Full name
Lígia Vanessa Rocha Fão

Citation names

  • Fão, Lígia
  • Fão L

Author identifiers

Ciência ID
BC15-D65C-1769
ORCID iD
0000-0003-1497-7894

Email addresses

  • ligia.fao@outlook.com (Professional)

Telephones

Telephone
  • 239820190 (Professional)

Addresses

  • Centro de Neurociências de Coimbra (CNC). Rua Larga, Ed. Faculdade de Medicina, Universidade de Coimbra (pólo I), 3004-504, Coimbra, Coimbra, Portugal (Professional)

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2017/09/26 - 2021/09
Ongoing
 Doctoral Programme in Health Sciences (Doutoramento)
Major in Biomedical Sciences - Neuroscience
Universidade de Coimbra, Portugal
2011/09/19 - 2016/09/21
Concluded
 Integrated Master's in Biomedical Engineering (Mestrado integrado)
Major in Neuroscience
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Amyloid-beta peptide-evoked Src signaling and redox changes in hippocampal cells" (THESIS/DISSERTATION)
 15/20
Affiliation

Science

Category
Host institution 		Employer
2016/09/01 - 2019/11/30 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

Category
Host institution 		Employer
2017/09/01 - Current PhD student - Doctoral Programme in Health Sciences - University of Coimbra Universidade de Coimbra Faculdade de Medicina, Portugal
2017/06/12 - 2019/11/30 BIM 4.1.1 fellowship in HealthyAging2020 Title: “HEALTHY AGING 2020 – WP4 - Changes in neurogenesis and mitochondrial function in Alzheimer's and Huntington's disease.” Project: Healthy Aging 2020 Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09/01 - 2017/04/01 Voluntary Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/09/01 - 2016/09/01 Master Thesis in Neurosciences Thesis Title: “Amyloid-beta peptide-evoked Src signaling and redox changes in hippocampal cells”. Thesis Grade: 18/20 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projects

Contract

Designation Funders
2021/11/01 - 2022/10/31 Examining Fyn/Src in Huntington’s Disease cell models.
1159/ACREGO
Technical development
Ongoing
2018/09 - 2021/08 Transcriptional activity modulation in Alzheimer's disease by inhibitors of histone deacetylases
PTDC/MED-TOX/32316/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/06/01 - 2020/11/30 “HEALTHY AGING 2020 – WP4 - Changes in neurogenesis and mitochondrial function in Alzheimer's and Huntington's disease.”
CENTRO-01-0145-FEDER-000012
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Ongoing
2018/10/01 - 2019/09/30 Exploring striatal postsynaptic SAPAP3 in Huntington’s disease
948/ACREGO
Concluded
Outputs

Publications

Conference poster
  1. Fão, Lígia; Coelho, Patrícia; Mota, Sandra I.; Ana Cristina Carvalho Rego. "c-Src/Fyn decreased levels in Huntington’s Disease – impact on mitochondrial function and ROS formation.". Paper presented in SPN 2021, 2021.
  2. Fão, Lígia; Sandra Isabel Freitas Mota; Ana Cristina Carvalho Rego. "c-Src/Fyn role in Huntington’s Disease progression". Paper presented in 23rd Annual Meeting of the Portuguese Society of Human Genetics., 2019.
  3. Fão, Lígia. "c-Src regulated Nrf2 activity through PKCd after an oxidant stimulus.". Paper presented in Portuguese Society of Neurosciences., 2019.
  4. Fão, Lígia. "Regulation of Nrf2 activity by Src Kinase Family and PKCd after an oxidant stimulus.". Paper presented in 9th Meeting on Signal Transduction, 2018.
  5. Fão, Lígia. "Oligomeric amyloid-beta peptide-induced redox dendritic mitochondrial changes in mature hippocampal neurons: role of NMDA receptors and Src kinase.". Paper presented in . MitoPorto International Symposium, 2018.
  6. Fão, Lígia. "Crosstalk between Src kinase and Nrf2 following oxidant stimulus - mitochondria and nucleus as relevant subcellular targets; and NMDA receptor-dependent redox changes and modified dendritic mitochondria following exposure to oligomeric amyloid-beta peptide in mature hippocampal neurons.". Paper presented in MitoPorto International Symposium, 2017.
  7. Fão, Lígia. "Induction of oxidative stress by amyloid-beta1-42 in mature hippocampal neurons: linking Src activity to Alzheimer’s disease.". Paper presented in . XL Portuguese Genetics Conference., 2016.
  8. Fão, Lígia; Sandra Isabel Freitas Mota; Ana Cristina Carvalho Rego. "Role of src kinase in oligomeric amyloid-betainduced early oxidative stress in mature hippocampal neurons - a link to alzheimer’s disease.". Paper presented in Synaptic Functions & Dysfunctions in Brain Disease – ISN, 2016.
Journal article
  1. Coelho, Patrícia; Fão L; Mota, Sandra; Rego, A. Cristina. "Mitochondrial function and dynamics in neural stem cells and neurogenesis: Implications for neurodegenerative diseases". Ageing Research Reviews 80 (2022): 101667. http://dx.doi.org/10.1016/j.arr.2022.101667.
    10.1016/j.arr.2022.101667
  2. Fão L; Coelho, Patrícia; Duarte, Luís; Vilaça, Rita; Hayden, Michael R.; Mota, Sandra I.; Rego, Ana Cristina. "Restoration of c-Src/Fyn Proteins Rescues Mitochondrial Dysfunction in Huntington's Disease". Antioxidants & Redox Signaling (2022): http://dx.doi.org/10.1089/ars.2022.0001.
    10.1089/ars.2022.0001
  3. Magalhães, João Duarte; Fão L; Vilaça, Rita; Cardoso, Sandra Morais; Rego, Ana Cristina. "Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions". Biomedicines 9 11 (2021): 1625. http://dx.doi.org/10.3390/biomedicines9111625.
    10.3390/biomedicines9111625
  4. Naia, Luana; Pinho, Catarina M.; Dentoni, Giacomo; Liu, Jianping; Leal, Nuno Santos; Ferreira, Duarte M. S.; Schreiner, Bernadette; et al. "Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling". BMC Biology 19 1 (2021): http://dx.doi.org/10.1186/s12915-021-00979-5.
    10.1186/s12915-021-00979-5
  5. Naia, Luana; Carmo, Catarina; Campesan, Susanna; Fão, Lígia; Cotton, Victoria E.; Valero, Jorge; Lopes, Carla; et al. "Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics". Free Radical Biology and Medicine 163 (2021): 163-179. http://dx.doi.org/10.1016/j.freeradbiomed.2020.11.031.
    10.1016/j.freeradbiomed.2020.11.031
  6. Fão, Lígia. "Mitochondrial and redox-based therapeutic strategies in Huntington's disease". Antioxidants and Redox Signaling (2020): https://pubmed.ncbi.nlm.nih.gov/32498555/.
    10.1089/ars.2019.8004
  7. Fão, Lígia. "Modified Glutamatergic Postsynapse in Neurodegenerative Disorders". Neuroscience (2019): http://dx.doi.org/10.1016/j.neuroscience.2019.12.002.
    10.1016/j.neuroscience.2019.12.002
  8. Fão, Lígia. "Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases". Ageing Research Reviews (2019): http://dx.doi.org/10.1016/j.arr.2019.100942.
    10.1016/j.arr.2019.100942
  9. Fão, Lígia. "c-Src regulates Nrf2 activity through PKCd after oxidant stimulus". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (2019): http://dx.doi.org/10.1016/j.bbamcr.2019.01.011.
    10.1016/j.bbamcr.2019.01.011
Thesis / Dissertation
  1. Fão, Lígia. "Amyloid-beta peptide-evoked Src signaling and redox changes in hippocampal cells". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2016.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/07/02 The involvement of c-Src/Fyn proteins in Huntington’s Disease mitochondrial dysfunction. 36aReunião do Grupo de Estudos de Envelhecimento Cerebral e Demência (GEECD).
(Coimbra, Portugal)
2021/07/06 Altered autophagy-dependent c- Src/Fyn degradation in Huntington’s Disease – impact on NMDAR activity. 45th FEBS Virtual Congress 2021 Ljubljana
(Ljubljana, Slovenia)
2020/10/17 Increased autophagy-dependent c-Src/Fyn degradation in Huntington’s Disease – impact on NMDAR activity Sociedade Portuguesa das Doenças!do Movimento (SPDMOV)
SPDMOV (Online, Portugal)
2019/10/18 Exploring the role of c-Src/Fyn tyrosine kinases in Huntington’s Disease; (Lígia Fão, Sandra Mota, A. Cristina Rego) 10th Meeting on Signal Transduction
Signal team (Olhão, Portugal)
2018/09/21 Role of NMDAR receptors and Src family kinases in amyloid-beta oligomers-induced mitochondrial changes in neurites. (Sandra Mota, Lígia Fão, A. Cristina Rego) 9th Meeting on Signal Transduction.
Signal Team (Lisboa, Portugal)
2017/02/16 Src signaling in Alzheimer’s disease-associated oxidative stress. (Lígia Fão, Sandra I. Mota, A. Cristina Rego= 5th Portuguese Meeting in Bioengineering
(Coimbra, Portugal)
2017/02/02 Oxidative Stress and Src Signaling in Alzheimer’s Disease. (Lígia Fão, Sandra I. Mota, A. Cristina Rego) XLVII Portuguese Society of Pharmacology.
(Coimbra, Portugal)
2016/06/03 Amyloid-beta1-42-induced oxidative stress in mature hippocampal neurons: role of Src kinase. (Lígia Fão, Sandra I. Mota, A. Cristina Rego) XXX Meeting of the Study Group on Brain Aging and Dementia
(Lisboa, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/09/01 - 2019/09/20 "Cell Signaling in Aging and Neurodegenerative Diseases" An exciting meeting with a multifaceted and highly interesting scientific program was prepared to create a unique opportunity to meet and discuss the latest research advances in understanding calcium signalling in the brain underlying aging and neurodegenerative disorders. (2019/09/18 - 2019/09/20)
Congress (Member of the Organising Committee)
 Universidade de Coimbra, Portugal

European Calcium Society, Belgium

Mentoring / Tutoring

Topic Student name
2019/09/25 - 2020/08/30 Supervisão laboratorial no âmbito da tese do "Mestrado em Biologia" Bruno Santos
2020/01/21 - 2020/02/19 Rotação laboratorial no âmbito do "Mestrado em Biologia Celular e Molecular" Francisca Silva
2018/04/03 - 2018/04/25 Rotação laboratorial no âmbito do mestrado "M1 Biologia Santé" (Biologia da Saúde) Marcelo Duarte Azevedo
Distinctions

Award

2021 Prize for best speed talk - 45th FEBS Virtual Congress 2021 Ljubljana
Federation of the European Biochemical Societies - FEBS, United Kingdom
2020 2o lugar na iniciativa Three minute-Thesis Competition da Universidade de Coimbra, no ano letivo 2019/2020.
Universidade de Coimbra, Portugal
2020 Invitation to participate at the 20th FEBS Young Scientists’ Forum
Federation of European Biochemical Societies, United Kingdom
2020 Prize for Best Basic Science Work - SPDMov 2020
Sociedade Portuguesa das Doenças do Movimento, Portugal