???global.info.a_carregar???
Bárbara B. Mendes obtained a BsC in Biomedical Sciences (2012) from Beira Interior University and a MsC in Biomedical Engineering (2014) from University of Oporto. In July 2020, Bárbara B. Mendes successfully defended her PhD on Tissue Engineering and Biomaterials from 3B's group at Minho University in collaboration with Prof. Jason Burdick at University of Pennsylvania (USA). She have acquired expertise on engineering intrinsically bioactive biomaterials as mimics of the native extracellular matrix. At the moment, the main outcomes of her research work are (1) throve blood derivatives-based biomaterials as modular extracellular matrix-mimetic scaffolds; (2) exploited human-based nanocomposite systems to meet personalized and complex 3D in vitro models conferring tissue-specific roles to the engineered scaffolds. In particular, hierarchical fibrillar network, mechanical properties (e.g., through cellulose nanocrystals content variation), and protein-engineered microenvironment (e.g., via native cell binding motifs and/or selective presentation of platelet derived-proteins). At her current postdoc fellowship, she has been profiling breast tumor heterogeneity in a cell-by-cell approach by designing logic synthetic gene circuits as a biobarcode of multicolor RNA circuits that will be efficient delivered to breast tumor microenvironment using bioresponsive nanohydrogels. The developed platform will be explored to evaluate pre-clinical nanomedicine therapy outcomes in a patient-by-patient basis. As a PhD student, she published 10 articles (6 as first-author) in renowned peer-reviewed journals (Biofabrication, Acta Biomaterialia, Advanced Drug Delivery Reviews), 1 book chapter, 1 international patent granted, and she orally presented in the most important conferences of the field, such as BMES'19, ESB'18, and TERMIS'17. As a junior researcher, from Oct 2020, she published 12 papers (7 as first author, 1 as corresponding author – ALL INDEPENDENT of her PhD collaborators, 2 papers just accepted); 2 journal covers; 3 patents (2 patents submitted, 1 in preparation); I presented 1 invited-talk; 1 invited-workshop; and 3 oral presentations with 73 citations. She is co-supervisor of 1 BSc, 1 MSc, and 1 PhD student (2nd year). She acquired animal FELASA certification (2022). She is a team member in EIC project (€2.5 M) and ERC ‘GelGeneCircuit’ project (€1.5 M). Finally, she is the PI of a FCT-funded exploratory project (€50 K) on 3D lung cancer models (2023). From July 2023 to December 2023, she was in maternity leave. Her h-index is 12/13 (Scopus/Scholar) with over 632/773citations (Scopus/Scholar) - Updated at 16.04.2024.
Identification

Personal identification

Full name
Bárbara Mendes

Citation names

  • Mendes, Bárbara
  • Bárbara B. Mendes

Author identifiers

Ciência ID
BD10-2F99-9DD9
ORCID iD
0000-0001-8630-1119

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Engineering and Technology - Nano-technology - Nano-materials
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Engineering and Technology - Industrial Biotechnology - Bioproducts Biomaterials
  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Upper intermediate (B2) Intermediate (B1)
Education
Degree Classification
2022/01 - 2022/02
Concluded
Curso Pós-Graduado de Experimentação Animal (Teórico e Prático) - 7ª Edição (Pós-Graduação)
Major in Experimentação Animal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/05/10 - 2021/05/17
Attended
3rd FLxFlow Course (Outros)
Fundação Champalimaud, Portugal

Instituto Gulbenkian de Ciência, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2015/09/01 - 2020/07/24
Concluded
Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais (Doutoramento)
Universidade do Minho - Instituto de Investigação em Biomateriais, Biodegradáveis, Biomiméticos;, Portugal
"Micro/Nano-structured hydrogels based on platelet lysate for tissue engineering and regeneration" (THESIS/DISSERTATION)
Very good with unanimity
2012/09/01 - 2014/10/15
Concluded
Engenharia Biomédica (Mestrado)
Universidade do Porto, Portugal
"Development and characterization of a co-culture two-dimensional blood-brain barrier for the study of nanoparticle permeation." (THESIS/DISSERTATION)
17 valores
2009 - 2012
Concluded
Ciências Biomédicas (Licenciatura)
Universidade da Beira Interior, Portugal
"n/a" (THESIS/DISSERTATION)
15 valores
Affiliation

Science

Category
Host institution
Employer
2020/10/01 - Current Contracted Researcher (Research) Universidade Nova de Lisboa, Portugal
Universidade Nova de Lisboa, Portugal
2019/02 - 2019/08 Visiting Researcher (Research) University of Pennsylvania Department of Bioengineering, United States
University of Pennsylvania Department of Bioengineering, United States

Positions / Appointments

Category
Host institution
Employer
2020/10 - 2021/10 Elected member of Postdoc Committee as representative of the Postdoc at CEDOC and Toxomics Universidade Nova de Lisboa, Portugal
2018 - 2019 Elected member of 3Bs Institute Council as representative of the PhD students I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Portugal, Portugal
Projects

Grant

Designation Funders
2020/10/01 - Current Cancer heterogeneity and therapy profiling using bioresponsive nanohydrogels for the delivery of multicolor logic genetic circuits
Researcher
Universidade Nova de Lisboa, Portugal
European Research Council
Ongoing
2015/09 - 2019/08 PhD scholarship - Micro/Nano-structured hydrogels based on platelet lysate for tissue engineering and regeneration
PD/BD/113807/2015
PhD Student Fellow
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023/01/01 - 2024/06/30 Organoides de tumores de pulmão para recriação do fenómeno da disseminação do tumor por via respiratória
2022.07775.PTDC
Principal investigator
Universidade NOVA de Lisboa, Portugal

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Centro Hospitalar Universitário de Lisboa Central EPE, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 ICVS/3B¿s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos
UID/Multi/50026/2019
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2023 - Current GENERA - A revolutionary, highly versatile drug delivery platform based on Metal-Organic Frameworks
Technical development
European Innovation Council
Ongoing
2019 - 2025 InjecTE - Injectable biomaterials for dental tissue engineering.
287953
Technical development
Universidade do Minho - Instituto de Investigação em Biomateriais, Biodegradáveis, Biomiméticos;, Portugal
Norges forskningsråd
Ongoing
2018 - 2023 MagTendon - Magnetic tissue engineering approaches for tendon regeneration.
772817
Technical development
Universidade do Minho - Instituto de Investigação em Biomateriais, Biodegradáveis, Biomiméticos;, Portugal
European Research Council
Ongoing
2018 - 2020 Nanoplant - Nanopatterned dental implants to enhance soft tissue integration and reduce bacterial colonization.
1306_2018
Technical development
Universidade do Minho - Instituto de Investigação em Biomateriais, Biodegradáveis, Biomiméticos;, Portugal
ITI Stiftung für Orale Implantologie und deren Grenzgebiete
Concluded
2011/07 - 2014/06 InVitroBrain - Development of a humanized dynamic in vitro blood-brain barrier model and a vesicle-based barrier for brain penetration of drugs incorporated in lipid nanoparticles - Closing the gap between in vivo and in vitro properties
Technical development
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Gomez-Florit, Manuel; Domingues, Rui M. A.; Bakht, Syeda Mahwish; Bárbara B. Mendes; Reis, Rui L.; Manuela E. Gomes. "Chapter 1.3.6. Natural Materials". In Biomaterials Science: An Introduction to Materials in Medicine, edited by William Wagner; Shelly Sakiyama-Elbert; Guigen Zhang; Michael Yaszemski. Elsevier, 2020.
    Published
  2. Gomes, Maria João; Mendes, Bárbara; Martins, Susana; Sarmento, Bruno. "Nanoparticle Functionalization for Brain Targeting Drug Delivery and Diagnostic". In Handbook of Nanoparticles, 941-959. Springer International Publishing, 2016.
    Published • 10.1007/978-3-319-15338-4_42
  3. Gomes, M.J.; Mendes, B.; Martins, S.; Sarmento, B.. "Cell-based in vitro models for studying blood-brain barrier (BBB) permeability". 169-188. 2016.
  4. Gomes, M.J.; Mendes, B.; Martins, S.; Sarmento, B.. "Nanoparticle functionalization for brain targeting drug delivery and diagnostic". 941-959. 2015.
Conference paper
  1. Mendes, B.B.; Gómez-Florit, M.; Randall, L.; Babo, P.S.; Almeida, R.C.; Detamore, M.S.; Domingues, R.M.A.; Reis, R.L.; Gomes, M.E.. "Human-based nanocomposite cryogels for hemostatic and wound healing applications". 2019.
  2. Silva, Elsa; Babo, Pedro; Costa-Almeida, Raquel; Domingues, Rui M. A.; Bárbara B. Mendes; Granja, Pedro L.; Manuela E. Gomes. "Multifunctional magnetic-responsive hydrogels modulate platelet lysate-derived growth factor release and guide cell fate.". Paper presented in Personalized Therapies for Regenerative Medicine, Davos, 2017.
    Published
  3. Marques, Claudia; Azevedo, Ana Rita; Carvalho, Isabel; Bárbara B. Mendes; Ferreira, M.; Ferreira, G.; Moreira, A. R.; et al. "Solid lipid nanoparticles as carriers for camptothecin delivery to brain tumor using an in vitro blood brain barrier model.". Paper presented in 51st Congress of the European Societies of Toxicology (EUROTOX), Porto, 2015.
    Accepted
  4. Sarmento, Bruno; Marques, Claudia; Azevedo, Ana Rita; Carvalho, Isabel; Mendes, Bárbara; Moreira, Gabriela; Moreira, Ana Rita; Costa, Paulo; Ferreira, Domingos. "Solid lipid nanoparticles as carriers for camptothecin delivery to brain tumor using an in vitro blood brain barrier model. Toxicity, permeability and inflammatory studies". Paper presented in Toxicology Letters, 2015.
    Published
Conference poster
  1. yasmina orraca; Bárbara B. Mendes; Amaral-Silva, Daniela; Conniot, João; Conde, João; helena soares. "Natural-based photocrosslinkable hydrogels for rheumatoid arthritis treatment". Paper presented in NMS PhD retreat, 2022.
  2. Syeda Mahwish Bakht; Lamers, Tara; Sixt, Milan; Gomez-Florit, Manuel; Bárbara B. Mendes; Reis, R. L.; Domingues, Rui M. A.; Gomes, Manuela E. "3D Printing/Bioprinting of Miniaturized Tissues Embedded in Self-Assembled Nanoparticle-based Fibrillar Platforms". Paper presented in TERMIS EU 2020, 2020.
  3. Bárbara B. Mendes. "Cellulose nanocrystals of variable sulfation degree for sequestering specific growth factors". Paper presented in TERMSTEM 2019, 2019.
  4. Bakht, Syeda Mahwish; Lamers, Tara; Gomez-Florit, Manuel; Sixt, Milan; Bárbara B. Mendes; Reis, Rui L.; Domingues, Rui M. A.; Manuela E. Gomes. "Combining 3D Printing with Nanoparticles Self-Assembly for the Fabrication of Fibrillar, Perfusable and Transparent Microfluidics Devices". Paper presented in 1st Discoveries Forum on regenerative and precision medicine., 2019.
  5. Bárbara B. Mendes; Gomez-Florit, Manuel; Randall, Lindsey; Babo, Pedro; Costa-Almeida, Raquel; Detamore, Michael S.; Domingues, Rui M. A.; Reis, Rui L.; Manuela E. Gomes. "Intrinsically bioactive cryogels for hemorrhage hemostasis and regenerative wound healing applications.". Paper presented in 30th Annual Meeting of the European Society for Biomaterials., 2019.
  6. Bárbara B. Mendes; Gomez-Florit, Manuel; Randall, Lindsey; Babo, Pedro; Costa-Almeida, Raquel; Detamore, Michael S; Domingues, Rui M. A.; Reis, Rui L.; Manuela E. Gomes. "Human-based hemostatic cryogels for wound healing applications.". Paper presented in CHEM2Nature – Final Conference, 2018.
  7. Domingues, Rui M. A.; Araújo-Custódio, Sandra; Tomás, A.; Bárbara B. Mendes; Gomez-Florit, Manuel; Babo, Pedro; Reis, Rui L.; Manuela E. Gomes. "Injectable and Magnetic Responsive Hydrogels with Bioinspired Ordered Structures for the Regeneration of Anisotropic Tissues". Paper presented in 29th Annual Meeting of the European Society for Biomaterials., 2018.
  8. Domingues, Rui M. A.; Araújo-Custódio, Sandra; Bárbara B. Mendes; Gomez-Florit, Manuel; Babo, Pedro; Reis, Rui L.; Manuela E. Gomes. "Cellulose nanocrystals as nanostructuring tools to modulate the artificial cell microenvironment in nanocomposite hydrogels". Paper presented in 5TH World TERMIS congress 2018, 2018.
  9. Gomez-Florit, Manuel; Bárbara B. Mendes; Domingues, Rui M. A.; Reis, Rui L.; Manuela E. Gomes. "Platelet Lysate-based Nanocomposite Bioink for 3D Printing in Tissue Engineering". Paper presented in 5TH World TERMIS congress 2018., 2018.
  10. Bárbara B. Mendes; Domingues, Rui M. A.; Reis, Rui L.; Manuela E. Gomes. "Human-based nanocomposite scaffolds towards new bioinstructive matrices to TERM strategies". Paper presented in Encontro de Ciência, 2018., 2018.
  11. Bakht, Syeda Mahwish; Domingues, Rui M. A.; Bárbara B. Mendes; Reis, Rui L.; Manuela E. Gomes. "Development of tunable supramolecular nanocomposite hydrogels as nanoinks for tissue specific needs in bioprinting". Paper presented in FORECAST 2017, 2017.
  12. Bárbara B. Mendes; Gomez-Florit, Manuel; Domingues, Rui M. A.; Reis, Rui L.; Manuela E. Gomes. "Platelet lysate loaded in nanocomposite bioinks towards a new generation of bioinks for TERM strategy". Paper presented in Forecast 2017, 2017.
  13. Gomez-Florit, Manuel; Bárbara B. Mendes; Domingues, Rui M. A.; Reis, Rui L.; Manuela E. Gomes. "Tunable Nanocomposite Bioactive Bioinks for 3D Printing in Tissue Engineering". Paper presented in 28th Annual Conference of the European Society for Biomaterials (ESB), 2017.
  14. Gomez-Florit, Manuel; Bárbara B. Mendes; Domingues, Rui M. A.; Reis, Rui L.; Manuela E. Gomes. "Research road map towards the development of scaffolds for tendon tissue engineering.". Paper presented in CHEM2Nature - Second School., 2017.
  15. Bárbara B. Mendes; Costa-Almeida, Raquel; Babo, Pedro; Domingues, Rui M. A.; Reis, Rui L.; Manuela E. Gomes. "Platelet lysate hydrogels enriched with oxidized cellulose nanocrystals.". Paper presented in TERM STEM 2016, 2016.
  16. Silva, Elsa; Babo, Pedro; Costa-Almeida, Raquel; Domingues, Rui M. A.; Bárbara B. Mendes; Granja, Pedro L.; Manuela E. Gomes. "Multifunctional magnetic-responsive hydrogels to engineer tendon-to-bone interface.". Paper presented in TERM STEM 2016, 2016.
  17. Marques, Claudia; Bárbara B. Mendes; Azevedo, A. R.; Costa, Paulo; Martins, Susana; Sarmento, Bruno; Ferreira, Domingos. "Drug loaded-lipid nanoparticles as carriers for drug delivery to glioma using an in vitro blood brain barrier model.". Paper presented in 11th International Conference on Nanosciences & Nanotechnologies, 2014.
  18. Marques, Claudia; Mendes, Bárbara; Azevedo, Ana Rita; Costa, Paulo; Martins, Susana; Ferreira, Domingos; Sarmento, Bruno. "Drug loaded-lipid nanoparticles as carriers for drug delivery to gliomas using an in vitro blood brain barrier model". Paper presented in 11th International Conference on Nanosciences & Nanotechnologies (NN14), 2014.
  19. Bárbara B. Mendes; Marques, Claudia; Costa, Paulo; Martins, Susana; Ferreira, Domingos; Sarmento, Bruno. "Development of an in vitro Blood-Brain Barrier model for drug-loaded solid lipid nanoparticles delivery". Paper presented in 5th International Conference on Advanced Nanomedicine., 2014.
  20. Bárbara B. Mendes; Marques, Claudia; Costa, Paulo; Martins, Susana; Ferreira, Domingos; Sarmento, Bruno. "Development and characterization of a co-culture two-dimensional blood-brain barrier for the study and correlation of drug permeation.". Paper presented in 7th meeting of new investigators of Porto University, 2014.
Journal article
  1. Calado, Rita D.A.; Mendes, Bárbara B.; Conniot, João; Ravasco, João M.J.M.; Sobral, Daniel; Ferreira, Carolina; Ferreira, Rita; et al. "Preclinical assessment of an antibiotic-free cationic surfactant-based cellulose hydrogel for sexually and perinatally transmitted infections". Matter (2024): http://dx.doi.org/10.1016/j.matt.2024.04.002.
    10.1016/j.matt.2024.04.002
  2. Prasad, Rajendra; Peng, Berney; Mendes, Bárbara B.; Kilian, Hailey I.; Gorain, Mahadeo; Zhang, Huijuan; Kundu, Gopal Chandra; et al. "Biomimetic bright optotheranostics for metastasis monitoring and multimodal image-guided breast cancer therapeutics". Journal of Controlled Release 367 (2024): 300-315. http://dx.doi.org/10.1016/j.jconrel.2024.01.056.
    10.1016/j.jconrel.2024.01.056
  3. Xu Chen; Bárbara B. Mendes; Yunhui Zhuang; João Conniot; Sergio Mercado Argandona; Francesca Melle; Diana P. Sousa; et al. "A Fluorinated BODIPY-Based Zirconium Metal–Organic Framework for In Vivo Enhanced Photodynamic Therapy". Journal of the American Chemical Society (2024): https://doi.org/10.1021/jacs.3c12416.
    10.1021/jacs.3c12416
  4. Bárbara B. Mendes. "A large-scale machine learning analysis of inorganic nanoparticles in preclinical cancer research". (2024):
    In press
  5. Fatima Hameedat; Bárbara B. Mendes; Conniot, João; Leonardo Filippo; Marcus Chorilli; Avi Schroeder; Conde, João; Sousa, Flávia. Corresponding author: Sousa, Flávia. "Engineering nanomaterials for glioblastoma nanovaccination". Nature Reviews Materials (2024):
  6. Prasad, Rajendra; Mendes, Bárbara B.; Gorain, Mahadeo; Chandra Kundu, Gopal; Gupta, Narendra; Peng, Berney; Aung Win, Eaint Honey; Qing, He; Conde, João. "Bioinspired and biomimetic cancer-cell-derived membrane nanovesicles for preclinical tumor-targeted nanotheranostics". Cell Reports Physical Science 4 11 (2023): 101648. http://dx.doi.org/10.1016/j.xcrp.2023.101648.
    Published • 10.1016/j.xcrp.2023.101648
  7. Bárbara B. Mendes; Oliveira, Jhenifer; Conde, João. Corresponding author: Bárbara B. Mendes. "Biomimetic hydrogel supporting baths as an alternative to initiate and maintain breast tumor-derived organoids culture". MedComm - Biomaterials and Applications (2023):
    Accepted
  8. Ruibo Zhong; Sepehr Talebian; Bárbara B. Mendes; Gordon Wallace; Robert Langer; João Conde; Jinjun Shi. "Hydrogels for RNA delivery". Nature Materials (2023): https://doi.org/10.1038/s41563-023-01472-w.
    10.1038/s41563-023-01472-w
  9. sepehr talebian; Bárbara Mendes; João Conniot; Syamak Farajikhah; Fariba Dehghani; Zhongyan Li; Diogo Bitoque; et al. "Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants". Advanced Science (2023): 2207603-2207603. http://dx.doi.org/10.1002/advs.202207603.
    Published • 10.1002/advs.202207603
  10. Liyi Fu; Yang Zhang; Ryan A. Farokhzad; Bárbara B. Mendes; João Conde; Jinjun Shi. "‘Passive’ nanoparticles for organ-selective systemic delivery: design, mechanism and perspective". Chemical Society Reviews (2023): https://doi.org/10.1039/D2CS00998F.
    10.1039/D2CS00998F
  11. Bárbara B. Mendes; Conniot, João; Avital, Aviram; Yao, Dongbao; Jiang, Xingya; Zhou, Xiang; Sharf-Pauker, Noga; et al. "Nanodelivery of nucleic acids". Nature Reviews Methods Primers 2 1 (2022): http://dx.doi.org/10.1038/s43586-022-00104-y.
    10.1038/s43586-022-00104-y
  12. Lorenc, Andzelika; Mendes, Bárbara B.; Conniot, João; Sousa, Diana P.; Conde, João; Rodrigues, Tiago. "Machine learning for next-generation nanotechnology in healthcare". Matter 4 10 (2021): 3078-3080. http://dx.doi.org/10.1016/j.matt.2021.09.014.
    10.1016/j.matt.2021.09.014
  13. Bárbara B. Mendes; Diana P. Sousa; João Conniot; João Conde. "Nanomedicine-based strategies to target and modulate the tumor microenvironment". Trends in Cancer (2021): https://doi.org/10.1016/j.trecan.2021.05.001.
    10.1016/j.trecan.2021.05.001
  14. Adriana Vilaça; Rui M. A. Domingues; Hanna Tiainen; Bárbara B. Mendes; Alejandro Barrantes; Rui L. Reis; Manuela E. Gomes; Manuel Gomez-Florit. "Multifunctional Surfaces for Improving Soft Tissue Integration". Advanced Healthcare Materials (2021): https://doi.org/10.1002/adhm.202001985.
    10.1002/adhm.202001985
  15. Bárbara B. Mendes; Andrew C. Daly; Rui L. Reis; Rui M.A. Domingues; Manuela E. Gomes; Jason A. Burdick. "Injectable hyaluronic acid and platelet lysate-derived granular hydrogels for biomedical applications". Acta Biomaterialia (2020): https://doi.org/10.1016/j.actbio.2020.10.040.
    10.1016/j.actbio.2020.10.040
  16. Bárbara B. Mendes. "Intrinsically Bioactive Cryogels Based on Platelet Lysate Nanocomposites for Hemostasis Applications". Biomacromolecules (2020): http://dx.doi.org/10.1021/acs.biomac.0c00787.
    10.1021/acs.biomac.0c00787
  17. Bárbara B. Mendes; Manuel Gómez-Florit; Hugo Osório; Adriana Vilaça; Rui M. A. Domingues; Rui L. Reis; Manuela E. Gomes. "Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response". Chemical Communications (2020): https://doi.org/10.1039/D0CC01850C.
    10.1039/D0CC01850C
  18. Mendes, Bárbara B; Gómez-Florit, Manuel; Hamilton, Alex G; Detamore, Michael S; Domingues, Rui M A; Reis, Rui L; Gomes, Manuela E. "Human platelet lysate-based nanocomposite bioink for bioprinting hierarchical fibrillar structures". Biofabrication 12 1 (2019): 015012. http://dx.doi.org/10.1088/1758-5090/ab33e8.
    Published • 10.1088/1758-5090/ab33e8
  19. Araújo-Custódio, Sandra; Gomez-Florit, Manuel; Tomás, Ana R.; Mendes, Bárbara B.; Babo, Pedro S.; Mithieux, Suzanne M.; Weiss, Anthony; et al. "Injectable and Magnetic Responsive Hydrogels with Bioinspired Ordered Structures". ACS Biomaterials Science & Engineering 5 3 (2019): 1392-1404. http://dx.doi.org/10.1021/acsbiomaterials.8b01179.
    Published • 10.1021/acsbiomaterials.8b01179
  20. Silva, Elsa D.; Babo, Pedro S.; Costa-Almeida, Raquel; Domingues, Rui M.A.; Mendes, Bárbara B.; Paz, Elvira; Freitas, Paulo; et al. "Multifunctional magnetic-responsive hydrogels to engineer tendon-to-bone interface". Nanomedicine: Nanotechnology, Biology and Medicine 14 7 (2018): 2375-2385. http://dx.doi.org/10.1016/j.nano.2017.06.002.
    10.1016/j.nano.2017.06.002
  21. Mendes, Bárbara B.; Gómez-Florit, Manuel; Babo, Pedro S.; Domingues, Rui M.; Reis, Rui L.; Gomes, Manuela E.. "Blood derivatives awaken in regenerative medicine strategies to modulate wound healing". Advanced Drug Delivery Reviews 129 (2018): 376-393. http://dx.doi.org/10.1016/j.addr.2017.12.018.
    Published • 10.1016/j.addr.2017.12.018
  22. Tamagno Pesqueira; Raquel Costa-Almeida; Suzanne M. Mithieux; Pedro S. Babo; Albina R. Franco; Bárbara B. Mendes; Rui M. A. Domingues; et al. "Engineering magnetically responsive tropoelastin spongy-like hydrogels for soft tissue regeneration". Journal of Materials Chemistry B 6 7 (2018): 1066-1075. https://doi.org/10.1039/C7TB02035J.
    Published • 10.1039/C7TB02035J
  23. Mendes, B.B.; Gómez-Florit, M.; Pires, R.A.; Domingues, R.M.A.; Reis, R.L.; Gomes, M.E.. "Human-based fibrillar nanocomposite hydrogels as bioinstructive matrices to tune stem cell behavior". Nanoscale 10 36 (2018): 17388-17401. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059804414&partnerID=MN8TOARS.
    Published • 10.1039/c8nr04273j
  24. Mendes, Bárbara; Marques, Cláudia; Carvalho, Isabel; Costa, Paulo; Martins, Susana; Ferreira, Domingos; Sarmento, Bruno. "Influence of glioma cells on a new co-culture in vitro blood brain barrier model for characterization and validation of permeability". International Journal of Pharmaceutics 490 1-2 (2015): 94-101. http://dx.doi.org/10.1016/j.ijpharm.2015.05.027.
    Published • 10.1016/j.ijpharm.2015.05.027
Thesis / Dissertation
  1. Bárbara B. Mendes. "Micro/Nano-structured hydrogels based on platelet lysate for tissue engineering and regeneration". PhD, Universidade do Minho, 2020.
  2. Bárbara Bruna da Silva Mendes. "Development and characterization of a co-culture two-dimensional blood-brain barrier for the study of nanoparticle permeation". Master, 2014. https://repositorio-aberto.up.pt/handle/10216/89528.

Intellectual property

Patent
  1. Bárbara B. Mendes; Domingues, Rui M. A.; Babo, Pedro; Reis, Rui L.; Manuela E. Gomes. 2017. "Blood derivatives composite material, methods of production and uses thereof.". Portugal.
    Granted/Issued

Other

Other output
  1. Hydrogels for RNA delivery. Nature Materials Reviews - Cover image.. 2023. Bárbara B. Mendes. https://doi.org/10.1038/s41563-023-01472-w.
  2. Nanodelivery of nucleic acids. Nature Reviews Methods Primers - PrimeView. 2022. Bárbara B. Mendes.
    https://doi.org/10.1038/s43586-022-00115-9
  3. Trends in Cancer Cover image. 2021. Bárbara B. Mendes; Conde, João; Diana P. Sousa; Conniot, João.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/10/20 In vitro recapitulation of breast tumor microenvironment for personalized theranostic strategies NMS PhD retreat
Nova Medical School
2022/05/18 Novel nanoplatforms for imaging and targeting the breast tumor microenvironment Encontro de Ciência e Tecnologia, 2022
Fundação para a Ciência e Tecnologia (Lisboa, Portugal)
2021/11 QAS-hydrogels as a promising microbicide against sexually and perinatal transmitted infections. Microbiotech 2021
Nova University Lisbon
2021/10 Biodegradable polymeric hydrogels as an effective vaginal microbicide delivery system. 3rd NMS symposium
Nova Medical School
2021/09 3D Bioprinting in Self-Assembled Nanoparticles to Fabricate Microphysiological Systems for Tissue/Organ-On-A Chip Applications. European Society for Biomaterials
(Portugal)
2021/09 Multifunctional coatings to improve soft tissue integration of metallic implants. European Society for Biomaterials
2019/11/04 Combining 3D Printing with Nanoparticles Self-Assembly for the Fabrication of Fibrillar, Perfusable and Transparent Microfluidics Devices. Second Achilles Conference
Universidade do Minho - Instituto de Investigação em Biomateriais, Biomiméticos e Biodegradáveis (Braga, Portugal)
2019/10 Platelet Lysate-Based Bioinks for 3D Printing Applications. BMES 2019 Annual Meeting
(Philadelphia, United States)
2019/06/12 Platelet Lysate-Based Nanocomposite Biomaterials for Tissue Engineering & Regenerative Medicine. In eCM Online Periodical 2019, Collection 2: Scandinavian Society for Biomaterials 2019 Conference. Page 13. Kirkkonummi, Finland. Scandinavian Society for Biomaterials.
(Kirkkonummi, Finland)
2018 Platelet lysate fibrillar nanocomposite bioink for soft tissues bioprinting. European Society for Biomaterials
(Maastritcht, Netherlands)
2018 Human-based nanocomposite bioink for freeform structures printing. Chem2Nature - Summer School
(Porto, Portugal)
2017/06/26 Injectable platelet lysate/cellulose nanocrystals hydrogels: a novel combined approach for regenerative medicine strategies. In eCM Meeting Abstracts 2017, Collection 2: Personalized Therapies for Regenerative Medicine, TERMIS-EU 2017. 0105. Davos, Switzerland. TERMIS-EU
(Davos, Switzerland)
2017 Incorporation of modified cellulose nanocrystals in platelet lysate-based hydrogels for 3D microenvironment sequestration of platelet lysate bioactive molecules. CHEM2Nature - Second School
(Porto, Portugal)
2016/11 Sulfated cellulose nanocrystals: synthesis and application on growth factors sequestering biomaterials. CHEM2Nature - First School
(Guimarães, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2024/01 - Current Development and characterization of tumour spread through air spaces (STAS) phenomenon three-dimensional in vitro model
Supervisor of Diogo Dias
BIOLOGIA CELULAR E MOLECULAR (Degree)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/09 - Current Profiling breast cancer heterogeneity using patient-derived organoids
Co-supervisor of Jhenifer Oliveira
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2024/01 - 2024/03 Glioblastoma multiforme targeted delivery of temozolomide using nanostructured lipid carriers
Supervisor of Mariana Jardim
Biomedical Engineering (Scientific initiation)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/09/01 - 2023/12/11 Development of novel nanoplatforms for the imaging and targeting of breast tumor microenvironment
Supervisor of Mariana Pereira
mestrado em oncobiologia (Master)
Universidade do Algarve, Portugal
2023/01/23 - 2023/07 Development of polymeric nanoparticles for Breast Cancer diagnosis, prognosis, and treatment
Supervisor
Bioquímica (Degree)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2021/10/11 - 2021/10/13 The CEDOC Post-Doctoral Committee organized the 3rd NMS Symposium on Chronic Diseases and Translational Science from 11th-13th October 2021. The Symposium aims to bring together young and established researchers from Portugal and abroad in a stimulating environment fostering both exchange and generation of new ideas. (2021/10/10 - 2021/10/13)
Conference (Co-organisor)
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2019/11/04 - 2019/11/05 Conference organizing comitee. 04 to 05 November 2019. Second Achilles Conference “Tendon Biophysical Environment”. Braga, Portugal. (2019/11/04 - 2019/11/05)
Conference (Member of the Organising Committee)
Universidade do Minho - Instituto de Investigação em Biomateriais, Biodegradáveis, Biomiméticos;, Portugal
2018/10/25 - 2018/10/26 CONFERENCE ORGANIZING COMITEE. 25 to 26 October 2018. CHEM2Nature – Final Conference. “Multifunctional Biomaterials Inspired by Nature”. Guimarães, Portugal. (2018/10/25 - 2018/10/26)
Conference (Member of the Organising Committee)
Universidade do Minho - Instituto de Investigação em Biomateriais, Biodegradáveis, Biomiméticos;, Portugal
2017/11/15 - 2017/11/17 CONFERENCE ORGANIZING COMITEE. 15 to 17 November 2017. Forecast. Porto, Portugal. (2017/11/15 - 2017/11/17)
Conference (Member of the Organising Committee)
Universidade do Minho - Instituto de Investigação em Biomateriais, Biodegradáveis, Biomiméticos;, Portugal
2016/11/21 - 2016/11/25 CONFERENCE ORGANIZING COMITTEE. 21 to 25 November 2016. CHEM2Nature – First School. Guimarães, Portugal. (2016/11/21 - 2016/11/25)
Conference (Member of the Organising Committee)
Universidade do Minho - Instituto de Investigação em Biomateriais, Biodegradáveis, Biomiméticos;, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2021/11/08 - 2021/11/12 The participants gain theoretical knowledge and are introduced to protocols and scientific methods related to lysosome and cilia biology, as well as being assisted to solve specific problems.
Workshop
LYSOCIL Summer School
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2021/10/12 - 2021/10/15 Biology of Cancer: Microenvironment & Metastasis.
Conference
Sixth Cold Spring Harbor Laboratory meeting
Cold Spring Harbor Laboratory, United States
2021/07/21 - 2021/07/22 R3 - Replace, Repair, Regenerate workshop attendance.
Workshop
Janelia Research Campus called ¿4D Cellular Physiology : R3 - Replace, Repair, Regenerate
2019/05/04 - 2019/05/04 Philly Motility conference attendance.
Meeting
Philly Motility 2019.
Drexel University, United States
2016/11 - 2016/11 B. B. Mendes, Oral presentation: "Orgãos à la Carte", PubhD Uminho, November 2016. STOL - Science Through Our Lives
Universidade do Minho Departamento de Biologia, Portugal

Association member

Society Organization name Role
2018 - Current European Society for Biomaterials (ESB) Member of the society.
2019 - 2020 Biomedical Engineering Society (BMES) Member of the society.
2017 - 2018 Tissue Engineering and Regenerative Medicine International Society (TERMIS) Member of the society.

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/05/07 - Current Emerging Technologies on tumor microenvironment biomimetic systems for drug screening| Hands-on Workshop (Outros) Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

TEC2MED, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2019 Research highlight "Cells thrive in blood-based bioink" by Physicsworld news journal. Physicsworld news

Journal scientific committee

Journal title (ISSN) Publisher
2021 - Current ACS biomaterials science & engineering. American Chemical Society
2017 - Current International Journal of Pharmaceutics (0378-5173) Elsevier

Mentoring / Tutoring

Topic Student name
2022/02 - 2022/06 Profiling breast cancer heterogeneity using polymeric nanoparticles for the delivery of multicolor genetic circuits Ana Maria Cunha
2022/04 - 2022/05 Development of polyplexes as nanocarriers for the delivery od DNA to Breast Cancer Cells Pedro Rosado
2022/01 - 2022/02 Development of polymeric nanoparticles for loading gene therapeutics Carolina Melo
2021/07 - 2021/08 Supervision through their first contact with laboratory equipment and scientific method of work. Beatriz Alves
2021/06 - 2021/07 Development of novel nanoplatforms for the imaging and targeting of breast tumor microenvironment Joana Amorim
2018/09/10 - 2019/02/09 Optimization of Cellulose Nanocrystal hydrogel support baths for high resolution 3D Bioprinting. Milan Sixt
2018/06/03 - 2018/08/03 Characterization of platelet lysate sponges reinforced with oxidized cellulose nanocrystals. Lindsey Randall
2016/08/01 - 2016/08/30 Supervision through their first contact with laboratory equipment and scientific method of work. Miguel Antunes
2016/08/01 - 2016/08/30 Supervision through their first contact with laboratory equipment and scientific method of work. Marisa Monteiro
Distinctions

Award

2022 Prémio Jovem Universitário de Ourém
Câmara Municipal de Ourém, Portugal
2021 Julia Polak European Doctorate Award 2021
European Society of Biomaterials, France

Other distinction

2015 PhD scholarship - PD/BD/113807/2015