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Deolinda Santinha. She completed her Master's degree in Biomedical Research at the Faculty of Medicine of the University of Coimbra in 2012 and obtained her first degree in Biomedical Laboratory Sciences at the Polytechnic Institute of Coimbra at the School of Health Technology of Coimbra in 2008. Since 2014, she has been enrolled in the PhD program in Aging and Chronic Diseases at the Faculty of Medicine of the University of Coimbra. During her PhD, she gained extensive experience in data analysis and visualization with R software and participated in several courses on data visualization and biostatistics with R software. She has published 15 articles in peer-reviewed journals. Has 1 section(s) of books. Organized 2 event(s). Has participated in 23 event(s). Has participated and/or collaborated on 1 project(s) as an Invited Scientist Fellow and 1 project(s) as a PhD Student Fellow. Works in the fields of Medicine and Health Sciences with a focus on Health Sciences, Medical Biotechnology (biomaterials, bioinformatics and technologies to manipulate cells, tissues, organs or the whole organism) and Basic Medicine (Immonology), Exact Sciences - Chemical Sciences with a focus on Analytical Chemistry (Proteomics and Lipidomics).
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Identification

Personal identification

Full name
Deolinda Santinha

Citation names

  • Santinha D
  • Santinha DR

Author identifiers

Ciência ID
BD19-E686-C979
ORCID iD
0000-0001-8948-5232

Addresses

  • Rua de Coimbra, 106, 3090-399, Caceira de Cima, Figueira da Foz, Portugal (Personal)

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Exact Sciences - Chemical Sciences - Analytical Chemistry
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Exact Sciences - Computer and Information Sciences - Bioinformatics

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2024/01/03
Concluded
 Biostatistics (Outros)
Universidade do Porto Faculdade de Ciências, Portugal
2014/10/01 - 2021/12/20
Ongoing
 Envelhecimento e Doenças Crónicas (Doutoramento)
Universidade de Coimbra, Portugal
2021/01/29
Concluded
 Análise Estatística e Multivariada em R (Outros)
Universidade de Coimbra, Portugal
 19
2019/11/04 - 2019/11/07
Concluded
 Integrative Biological Interpretation using Proteomics (Outros)
Gulbenkian Institute for Molecular Medicine, Portugal
2018/09/24 - 2018/09/28
Concluded
 Quantitative Fluorescence Microscopy Course (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/02/11
Concluded
 Investigação Biomédica (Mestrado integrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
"Changes in lipidomic profile induced by lipopolysaccharide and skin sensitizer in dendritic cells and keratinocytes " (THESIS/DISSERTATION)
 17
2004/09/17 - 2008/09/18
Concluded
 Ciências Biomédicas Laboratoriais (Licenciatura)
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
"Quantificação da frequência de células T e NK do sangue periférico produtoras de Factor de Necrose Tumoral-alfa (TNF-a) e quantificação desta proteína por célula em indivíduos com Esclerose Múltipla" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2021/10/15 - 2022/04/15 Research Assistant (Research) Universidade de Coimbra Departamento de Química, Portugal
2019/06/01 - 2021/03/30 Research Assistant (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
2016/10/01 - 2019/04/01 Research Trainee (Research) CNC.IBILI, Portugal
CNC.IBILI, Portugal
2012/02/02 - 2013/06/04 Research Assistant (Research) Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal

Others

Category
Host institution 		Employer
2022/05/07 - 2022/11/30 Biomedical Laboratory Scientist Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2013/08/01 - 2014/09/30 Biomedical Laboratory Scientist Laboratório de Análises Clínicas Santo Estevão, Portugal
2011/07/01 - 2011/12/30 Biomedical Laboratory Scientist Hospitais da Universidade de Coimbra, Portugal
Projects

Contract

Designation Funders
2014/10/01 - 2019/03/31 Changes in Extracellular Matrix of the Pathological and Physiological Cardiac Aging
PD / BD / 106051 / 2015
PhD Student Fellow
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing

Other

Designation Funders
2021/06 - 2022/04 RESETageing
952266
Invited Scientist Fellow
Universidade de Coimbra, Portugal
Ongoing
Outputs

Publications

Book chapter
  1. Deolinda Santinha; Andreia Vilaça; Alessandro Ori; Lino Ferreira. "The extracellular matrix in cardiovascular aging". In Aging - From Fundamental Biology to Societal Impact. Elsevier, 2022.
    10.1016/c2020-0-00576-1
Journal article
  1. Deolinda Santinha; Andreia Vilaça; Luís Estronca; Svenja C. Schüler; Catherine Bartoli; Annachiara De Sandre-Giovannoli; Arnaldo Figueiredo; et al. "Remodeling of the Cardiac Extracellular Matrix Proteome During Chronological and Pathological Aging". Molecular & Cellular Proteomics (2024): https://doi.org/10.1016/j.mcpro.2023.100706.
    10.1016/j.mcpro.2023.100706
  2. Almeida, H.V.; Tenreiro, M.F.; Louro, A.F.; Abecasis, B.; Santinha, D.; Calmeiro, T.; Fortunato, E.; et al. "Human Extracellular-Matrix Functionalization of 3D hiPSC-Based Cardiac Tissues Improves Cardiomyocyte Maturation". ACS Applied Bio Materials 4 2 (2021): 1888-1899. http://www.scopus.com/inward/record.url?eid=2-s2.0-85101037290&partnerID=MN8TOARS.
    10.1021/acsabm.0c01490
  3. Schüler, Svenja C; Kirkpatrick, Joanna M; Schmidt, Manuel; Santinha, Deolinda; Koch, Philipp; Di Sanzo, Simone; Cirri, Emilio; et al. "Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality". Cell Reports 35 10 (2021): http://hdl.handle.net/10316/100614.
    https://doi.org/10.1016/j.celrep.2021.109223
  4. Katarzyna Buczak; Joanna M. Kirkpatrick; Felicia Truckenmueller; Deolinda Santinha; Lino Ferreira; Stephanie Roessler; Stephan Singer; Martin Beck; Alessandro Ori. "Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry". Nature Protocols (2020): https://doi.org/10.1038%2Fs41596-020-0356-y.
    10.1038/s41596-020-0356-y
  5. Santinha, Deolinda; Klopot, Anna; Marques, Igor; Ellis, Ewa; Jorns, Carl; Johansson, Helene; Melo, Tânia; et al. "Lipidomic analysis of human primary hepatocytes following LXR activation with GW3965 identifies AGXT2L1 as a main target associated to changes in phosphatidylethanolamine". The Journal of Steroid Biochemistry and Molecular Biology 198 (2020): 105558. http://dx.doi.org/10.1016/j.jsbmb.2019.105558.
    10.1016/j.jsbmb.2019.105558
  6. Pitrez, Patrícia R.; Estronca, Luís Miguel Beicinha Branco; Monteiro, Luís Miguel Marques; Colell, Guillem; Vazão, Helena; Santinha, Deolinda da Conceição Ribafeita; Harhouri, Karim; et al. "Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13". Nature Communications (2020): http://hdl.handle.net/10316/92394.
    https://doi.org/10.1038/s41467-020-17901-2
  7. Araújo, Ana Rita D.; Melo, Tânia; Maciel, Elisabete A.; Pereira, Clara; Morais, Catarina M.; Santinha, Deolinda R.; Tavares, Joana F.; et al. "Errors in protein synthesis increase the level of saturated fatty acids and affect the overall lipid profiles of yeast". PLOS ONE 13 8 (2018): e0202402. http://hdl.handle.net/10316/107991.
    https://doi.org/10.1371/journal.pone.0202402
  8. Couto D; Santinha D; Melo T; Ferreira-Fernandes E; Videira RA; Campos A; Fardilha M; Domingues P; Domingues MR. "Glycosphingolipids and oxidative stress: evaluation of hydroxyl radical oxidation of galactosyl and lactosylceramides using mass spectrometry.". Chemistry and physics of lipids (2015): http://europepmc.org/abstract/med/26315528.
    10.1016/j.chemphyslip.2015.08.014
  9. Santinha D; Ferreira-Fernandes E; Melo T; Silva EM; Maciel E; Fardilha M; Domingues P; Domingues MR. "Evaluation of the photooxidation of galactosyl- and lactosylceramide by electrospray ionization mass spectrometry.". Rapid communications in mass spectrometry : RCM (2014): http://europepmc.org/abstract/med/25279740.
    10.1002/rcm.7020
  10. Faria R; Santana MM; Aveleira CA; Simões C; Maciel E; Melo T; Santinha D; et al. "Alterations in phospholipidomic profile in the brain of mouse model of depression induced by chronic unpredictable stress.". Neuroscience (2014): http://europepmc.org/abstract/med/24814727.
    10.1016/j.neuroscience.2014.04.042
  11. Maciel E; Neves BM; Santinha D; Reis A; Domingues P; Teresa Cruz M; Pitt AR; Spickett CM; Domingues MR. "Detection of phosphatidylserine with a modified polar head group in human keratinocytes exposed to the radical generator AAPH.". Archives of biochemistry and biophysics (2014): http://europepmc.org/abstract/med/24560783.
    10.1016/j.abb.2014.02.002
  12. Antunes, Diana; Padrão, Ana Isabel; Maciel, Elisabete; Santinha, Deolinda; Oliveira, Paula; Vitorino, Rui; Moreira-Gonçalves, Daniel; et al. "Molecular insights into mitochondrial dysfunction in cancer-related muscle wasting". Biochimica et biophysica acta (2014): http://hdl.handle.net/10348/4870.
    10.1016/j.bbalip.2014.03.004
  13. Maciel E; Faria R; Santinha D; Domingues MR; Domingues P. "Evaluation of oxidation and glyco-oxidation of 1-palmitoyl-2-arachidonoyl-phosphatidylserine by LC-MS/MS.". Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (2013): http://europepmc.org/abstract/med/23669606.
    10.1016/j.jchromb.2013.04.009
  14. Santinha DR; Dória ML; Neves BM; Maciel EA; Martins J; Helguero L; Domingues P; Cruz MT; Domingues MR. "Prospective phospholipid markers for skin sensitization prediction in keratinocytes: a phospholipidomic approach.". Archives of biochemistry and biophysics (2013): http://europepmc.org/abstract/med/23474456.
    10.1016/j.abb.2013.02.012
  15. Santinha DR; Marques DR; Maciel EA; Simões CS; Rosa S; Neves BM; Macedo B; et al. "Profiling changes triggered during maturation of dendritic cells: a lipidomic approach.". Analytical and bioanalytical chemistry (2012): http://europepmc.org/abstract/med/22402731.
    10.1007/s00216-012-5843-8
Thesis / Dissertation
  1. Santinha, Deolinda da Conceição Ribafeita; Santinha D. "Changes in lipidomic profile induced by lipopolysaccharide and skin sensitizer in dendritic cells and keratinocytes". Master, 2011. http://hdl.handle.net/10316/31379.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/03/02 Remodelling Of The Cardiac Extracellular Matrix Proteome During Chronological And Pathological Ageing II Congresso BioMedLab
Associação Portuguesa de Ciências Biomédicas Laboratoriais (Coimbra, Portugal)
2021/11/16 Extracellular matrix during physiological and pathological cardiac ageing: a proteomic study 6th TERMIS World Congress
Tissue Engineering and Regenerative Medicine International Society (TERMIS) (Maastricht, Netherlands)
2021/06/11 Extracellular matrix during physiological and pathological cardiac ageing: a proteomic study 55rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) - Online Event
European Society for Clinical Investigation (ESI)
2021/06/05 A matriz extracelular durante o envelhecimento cardíaco fisiológico e patológico: um estudo de proteómica Webinar "Investigação, um mundo de oportunidades"
Associação Portuguesa de Técnicos de Análises Clínicas e Saúde Pública
2012/04/23 Changes in lipidomic profile induced by lipopolysaccharide and skin sensitizer in dendritic cells and keratinocytes VI Jornadas de Bioquímica - Universidade de Aveiro
Universidade de Aveiro (Aveiro, Portugal)
2007/11/29 Comunicações Livres do Curso de Análises Clínicas e Saúde Pública, integradas no I Congresso de Ciências Aplicadas na Saúde Comunicações Livres do Curso de Análises Clínicas e Saúde Pública, integradas no I Congresso de Ciências Aplicadas na Saúde
I Congresso de Ciências Aplicadas na Saúde (Coimbra, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/06/28 - 2019/06/29 Ageing: models, mechanisms and therapies (2019/06/28 - 2019/06/29)
Conference (Member of the Organising Committee)
 Universidade de Coimbra, Portugal
2008/02/29 - 2008/03/01 VIII Jornadas de Análises Clínicas e Saúde Pública (2008/02/29 - 2008/03/01)
Congress (Member of the Organising Committee)
 Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/03/01 - 2024/03/03 II Congresso BioMedLab
Conference
 II Congresso BioMedLab
Associação Portuguesa de Ciências Biomédicas Laboratoriais, Portugal
2022/12/06 - 2022/12/15 Participation in the Course of "Escolas Doutorais" in Data vizualization with R software
Universidade de Coimbra, Portugal
2022/12/06 - 2022/12/07 Poster presentation AGEING WITHOUT BORDERS Meeting
Conference
 AGEING WITHOUT BORDERS Meeting
Universidade do Algarve, Portugal
2021/11/15 - 2021/11/19 6th TERMIS World Congress
Congress
 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021)
2021/06/09 - 2021/06/11 55th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) - Online Event
Congress
 55th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
2020/12/03 - 2020/12/03 2nd edition of the University of Coimbra Three-Minute Thesis Competition, 2020/2021
Other
Universidade de Coimbra, Portugal
2019/06/28 - 2019/06/29 Porter presentation at Conference "Ageing: models, mechanisms and therapies"
Conference
 Ageing: models, mechanisms and therapies
Universidade de Coimbra, Portugal
2019/05/22 - 2019/05/24 Poster Presentation at the 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
Congress
 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
European Society for Clinical Investigation, Netherlands
2019/05/15 - 2019/05/17 Poster presentation at the Annual Meeting of the French Society for Extracellular Matrix
Conference
 Annual Meeting of the French Society for Extracellular Matrix
Université de Reims Champagne-Ardenne, France
2017/11/28 - 2017/11/28 5º Congresso Regional sobre Envelhecimento Ativo e Saudável
Conference
 Ageing@Coimbra
Universidade de Coimbra, Portugal
2017/04/05 - 2017/04/05 6th WORKSHOP IN LIPIDOMICS
Conference
 6th WORKSHOP IN LIPIDOMICS
Universidade de Aveiro, Portugal
2013/05/09 - 2013/05/11 Poster presentattion at the XIII Congresso Sociedade Ibérica de Citometria
Congress
 XIII Congresso Sociedade Ibérica de Imunologia
Universitat de València Centro de Citometría y Citómica, Spain
2011/04/27 - 2011/04/27 V Jornadas de Bioquímica
Conference
Universidade de Aveiro, Portugal
2010/10/22 - 2010/10/26 Participation in the course "Introduction to Pharmacogenomics - Clinical Applications"
Seminar
Universidade de Coimbra Faculdade de Medicina, Portugal
2009/11/01 - 2009/11/01 1st Annual Meeting of IBILI
Congress
 1st Annual Meeting of IBILI
CNC.IBILI, Portugal
2008/04/24 - 2008/04/24 Seminar in "Learming and Employability"
Seminar
 Learning and Employability
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2008/03/31 - 2008/04/06 Participação na Semana das Ciências Aplicadas na Saúde 2008 a decorrer na Praça da República em Coimbra, realizando acções de rastreio e sensibilização à população Semana das Ciências Aplicadas na Saúde 2008
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2007/11/29 - 2007/11/30 Workshops teórico-práticos “Epidemiologia e perfil de resistência antimicrobiana de Clostridium difficile num Hospital de adultos” e “Investigação em Saúde Pública" I Congresso das Ciências Aplicadas na Saúde
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2007/11/17 - 2007/11/17 1º Colóquio do Departamento das Ciências Laboratoriais Aplicadas na Saúde
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2007/02/23 - 2007/02/24 VII Jornadas de Análises Clínicas e Saúde Pública VII Jornadas de Análises Clínicas e Saúde Pública
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2006/04/03 - 2006/04/09 Participação como voluntária na Semana das Ciências Aplicadas à Saúde 2006 a decorrer na Praça da República em Coimbra, realizando acções de rastreio e sensibilização à população Semana das Ciências Aplicadas à Saúde 2006
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2006/03/03 - 2006/03/04 VI Jornadas de Análises Clínicas e Saúde Pública VI Jornadas de Análises Clínicas e Saúde Pública
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2005/11/28 - 2005/11/30 III Tertúlias das Ciências Aplicadas na Saúde III Tertúlias das Ciências Aplicadas na Saúde
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal

Mentoring / Tutoring

Topic Student name
2012/03/01 - 2012/07/01 Alterations in phospholipidomic profile in the brain of mouse model of depression induced by chronic unpredictable stress. Renata Faria
2012/03/01 - 2012/06/30 Molecular insights into mitochondrial dysfunction in cancer-related muscle wasting Diana Antunes