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Ivo F. Machado concluiu o Mestrado em Biologia Celular e Molecular em 2019 pela Faculdade de Ciências e Tecnologia da Universidade de Coimbra e a Licenciatura em Bioquímica em 2017 pela Faculdade de Ciências e Tecnologia da Universidade de Coimbra. Atualmente, é aluno de doutoramento na Universidade de Coimbra. Ele é autor/co-autor de 10 artigos em revistas especializadas e de 5 capítulos de livro.
Identification

Personal identification

Full name
Ivo Manuel Ferreira Machado

Citation names

  • Machado, I.F.
  • Machado, Ivo F.

Author identifiers

Ciência ID
BD1D-EF4F-2F65
ORCID iD
0000-0002-9666-4594

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2020 - 2024
Ongoing
 Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017/08 - 2019/07
Concluded
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Modulation of complex I and oxidative capacity in cells under metabolic stress: the interplay between miR-378a-3p and metformin" (THESIS/DISSERTATION)
 19 valores
2014/09 - 2017/06
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 17 valores
Affiliation

Science

Category
Host institution 		Employer
2019/10 - 2020/12 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Outputs

Publications

Book chapter
  1. Palmeira, Carlos M.; Machado, Ivo F.; Ramalho-Santos, João. "Mitochondrial dysfunction in reproductive and developmental toxicity". In Reproductive and Developmental Toxicology, 1103-1116. Elsevier, 2022.
    Published • 10.1016/b978-0-323-89773-0.00054-0
  2. Teodoro, João S.; Machado, Ivo F.; Castela, Ana C.; Rolo, Anabela P.; Palmeira, Carlos M.. "Mitochondria as a target for safety and toxicity evaluation of nutraceuticals". In Nutraceuticals: Efficacy, Safety and Toxicity, edited by Gupta, Ramesh C.. United States: Academic Press/Elsevier, 2021.
    Published • 10.1016/B978-0-12-821038-3.00030-6
  3. Teodoro, João S.; Machado, Ivo F.; Palmeira, Carlos M.; Rolo, Anabela P.. "Determination of oxidative phosphorylation complexes activities". In Methods in Molecular Biology, 17-31. Springer US, 2021.
    10.1007/978-1-0716-1433-4_2
  4. Machado, Ivo F.; Teodoro, João S.; Castela, Ana C.; Palmeira, Carlos M.; Rolo, Anabela P.. "Mitohormesis". In Mitochondrial Physiology and Vegetal Molecules, 729-746. Elsevier, 2021.
    Published • 10.1016/b978-0-12-821562-3.00035-6
  5. Teodoro, João S.; Machado, Ivo F.; Castela, Ana C.; Rolo, Anabela P.; Palmeira, Carlos M.. "Evaluation of mitochondrial membrane potential using fluorescent dyes or a membrane-permeable cation (TPP+) electrode in isolated mitochondria and intact cells". In Immunometabolism. Methods in Molecular Biology, edited by Mishra, Suresh. United States: Springer US, 2020.
    Published • 10.1007/978-1-0716-0802-9_14
Conference abstract
  1. Machado, Ivo F.; Teodoro, João S.; Palmeira, Carlos M.; Rolo, Anabela P.. "Interplay between metformin and miR-378a-3p in cells under hyperglycaemia". Paper presented in 12th MiP/MitoEAGLE Training School, 2019.
    10.26124/mitofit:ea19.mipschool.0008
  2. João Teodoro; Anabela Rolo; Rui Silva; Ivo Machado; Joan Rosello-Catafau; Clemens Steegborn; Carlos Palmeira. "Novel avenues of ischemia/reperfusion injury prevention: lessons from a soluble adenylyl cyclase inhibitor and a SirT3 activator". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2019.
    10.1111/eci.13108
Conference poster
  1. Ivo Machado; João Teodoro; Carlos Palmeira; Anabela Rolo. "Modulation of complex I and oxidative capacity in cells under metabolic stress". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2019.
    10.1111/eci.13109
Journal article
  1. Ivo F. Machado; Raul G. Miranda; Daniel J. Dorta; Anabela P. Rolo; Carlos M. Palmeira. "Targeting Oxidative Stress with Polyphenols to Fight Liver Diseases". Antioxidants (2023): https://doi.org/10.3390/antiox12061212.
    10.3390/antiox12061212
  2. Ivo F. Machado; Carlos M. Palmeira; Anabela P. Rolo. "Preservation of Mitochondrial Health in Liver Ischemia/Reperfusion Injury". Biomedicines (2023): https://doi.org/10.3390/biomedicines11030948.
    10.3390/biomedicines11030948
  3. João S. Teodoro; Rui T. Da Silva; Ivo F. Machado; Arnau Panisello-Roselló; Joan Roselló-Catafau; Anabela P. Rolo; Carlos M. Palmeira. "Shaping of Hepatic Ischemia/Reperfusion Events: The Crucial Role of Mitochondria". Cells 11 4 (2022): 688-688. https://doi.org/10.3390/cells11040688.
    10.3390/cells11040688
  4. Rui Teixeira da Silva; Ivo F. Machado; João S. Teodoro; Arnau Panisello-Roselló; Joan Roselló-Catafau; Anabela P. Rolo; Carlos M. Palmeira. "PEG35 as a Preconditioning Agent against Hypoxia/Reoxygenation Injury". International Journal of Molecular Sciences 23 3 (2022): 1156-1156. https://doi.org/10.3390/ijms23031156.
    10.3390/ijms23031156
  5. João S. Teodoro; Ivo F. Machado; Ana C. Castela; João A. Amorim; Ivana Jarak; Rui A. Carvalho; Carlos M. Palmeira; Anabela P. Rolo. "Chenodeoxycholic Acid Has Non-Thermogenic, Mitodynamic Anti-Obesity Effects in an In Vitro CRISPR/Cas9 Model of Bile Acid Receptor TGR5 Knockdown". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms222111738.
    10.3390/ijms222111738
  6. Piochi, Luiz F.; Machado, Ivo F.; Palmeira, Carlos M.; Rolo, Anabela P.. "Sestrin2 and mitochondrial quality control: Potential impact in myogenic differentiation". Ageing Research Reviews 67 (2021): 101309. http://dx.doi.org/10.1016/j.arr.2021.101309.
    10.1016/j.arr.2021.101309
  7. Oliveira, Raúl P.; Machado, Ivo F.; Palmeira, Carlos M.; Rolo, Anabela P.. "The potential role of sestrin 2 in liver regeneration". Free Radical Biology and Medicine 163 (2021): 255-267. http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.027.
    Published • 10.1016/j.freeradbiomed.2020.12.027
  8. Machado, Ivo F.; Teodoro, João S.; Castela, Ana C.; Palmeira, Carlos M.; Rolo, Anabela P.. "miR-378a-3p participates in metformin's mechanism of action on C2C12 cells under hyperglycemia". International Journal of Molecular Sciences 22 2 (2021): 541. https://doi.org/10.3390/ijms22020541.
    Published • 10.3390/ijms22020541
  9. Teodoro, João S.; Amorim, João A.; Machado, Ivo F.; Castela, Ana C.; Steegborn, Clemens; Sinclair, David A.; Rolo, Anabela P.; Palmeira, Carlos M.. "The soluble adenylyl cyclase inhibitor LRE1 prevents hepatic ischemia/reperfusion damage through improvement of mitochondrial function". International Journal of Molecular Sciences 21 14 (2020): 4896-4896. https://doi.org/10.3390/ijms21144896.
    Published • 10.3390/ijms21144896
  10. Machado, Ivo F.; Teodoro, João S.; Palmeira, Carlos M.; Rolo, Anabela P.. "miR-378a: a new emerging microRNA in metabolism". Cellular and Molecular Life Sciences 77 10 (2020): 1947-1958. http://dx.doi.org/10.1007/s00018-019-03375-z.
    Published • 10.1007/s00018-019-03375-z
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/07/08 Interplay between metformin and miR-378a-3p in cells under hyperglycaemia 12th MiP/MitoEAGLE Training School
Universidade de Coimbra Faculdade de Ciencias e Tecnologia (Coimbra, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/09/27 - 2022/10/01 Mechanisms of Aging
Conference
Cold Spring Harbor Laboratory, United States
2020/01/21 - 2020/01/21 Oficina BCM nas escolas (Gabinete de Apoio à Divulgação da Universidade de Coimbra). Atividades teórico-práticas no âmbito da Biologia Celular e Molecular para alunos do 11º ano na Escola Secundária Lima de Faria (Cantanhede)
Workshop
Universidade de Coimbra, Portugal
2019/05/22 - 2019/05/24 Participação e apresentação de poster - "Modulation of complex I and oxidative capacity in cells under metabolic stress"
Meeting
 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
European Society for Clinical Investigation, Netherlands
2019/01/18 - 2019/01/18 Oficina BCM nas escolas (Gabinete de Apoio à Divulgação da Universidade de Coimbra). Atividades teórico-práticas no âmbito da Biologia Celular e Molecular para alunos do 11º ano na Escola Básica e Secundária Dr. Pascoal José de Melo (Ansião)
Workshop
Universidade de Coimbra, Portugal
2019/01/18 - 2019/01/18 Oficina BCM nas escolas (Gabinete de Apoio à Divulgação da Universidade de Coimbra). Atividades teórico-práticas no âmbito da Biologia Celular e Molecular para alunos do 11º ano na Escola Secundária Lima de Faria (Cantanhede)
Workshop
Universidade de Coimbra, Portugal
Distinctions

Other distinction

2020 PhD Research Scholarship
Fundação para a Ciência e a Tecnologia, Portugal