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F. Santos graduated in biochemistry in 2008 at Universidade de Évora, completing a diploma thesis on urease activity in olive grove soil samples and Fusarium oxysporum. Part of this work was published in a national reference journal in AGRICULTURAL SCIENCES. The knowledge acquired sparked her deep interest in fungi, later proven to be crucial for the development of the PhD project. She was awarded a COMPETITIVE FELLOWSHIP (BD-Mic/12A/08), in 2009, under the EUROPEAN PROJECT “Safewater - Development and validation of integrated drinking water treatment processes in Portugal and Norway” (EEA Grants) at IBET, using advanced analytical and decontamination techniques on real water samples. She completed the MSc. in Inorganic Biomedical Chemistry at Universidade de Lisboa, in 2011, focusing on anticancer metallodrugs and their interaction with biomolecules. Following her MSc., she was AWARDED several COMPETITIVE RESEARCH FELLOWSHIPS to work in FCT-funded projects (PTDC/Qui-Qui/101187/2008; PTDC/Qui-Qui/118077/2010), which endowed her with expertise in several other techniques, such as hydrodynamic viscosity, lipophilicity studies, cytotoxicity and genotoxicity - Ames test (Genetics Department, NOVA Medical School). Her work resulted in 4 publications in J. Inorg. Biochem. and 1 in BioMetals. The knowledge acquired showed to be extremely useful for her PhD, since she learned to handle light and oxygen-sensitive compounds. She had the first contact with Molecular Biophysics group, where she was hired as a research fellow under the R&D Unit’s Strategic Projects, being after a while AWARDED a FCT PhD fellowship (SFRH/BD/108031/2015) allowing her to pursuit the research she planned. F. Santos obtained her PHD in Biochemistry (Molecular Biophysics) with Distinction on January 6th, 2023. Her PhD focused on the biophysical characterization of the fungal plasma membrane (PM), combining her favourite interests, fungi and biophysics. During her PhD, she AUTONOMOUSLY IMPLEMENTED N. crassa growth and manipulation techniques, after visiting Prof. Arnaldo Vieira’s lab (I3S, Porto). F. Santos PUBLISHED THE FIRST COMPREHENSIVE STUDIES IN NEUROSPORA CRASSA PM BIOPHYSICAL PROPERTIES, demonstrating the importance of PM domains for fungal development (BBA – Mol Cell Biol Lipids) and drug response (Front Physiol). Additionally, she studied the relationship between membrane protein compartments and lipid domains in Saccharomyces cerevisiae, using fluorescence spectroscopy (steady-state and time-resolved) and confocal FLIM (Biomol.) and determined the antifungal activity of new derivatives of Ketoconazole against yeast strains (Sci. Rep.). Her PhD culminated with a FIRST AUTHORSHIP OF AN INVITED REVIEW IN FEBS LETTERS entitled “Sphingolipid-enriched domains in fungi”. She also had the opportunity to COLLABORATE in a MULTIDISCIPLINARY PROJECT, resulting in publications in HIGH-IMPACT JOURNALS, Redox Biol. She was SELECTED to participate in the FEBS Advanced Practical Course – Microspectroscopy: Functional imaging of biological systems (Netherlands, 2018) and received a YOUTH TRAVEL FUND GRANT, as well as an EBSA FELLOWSHIP to present a communication at the 59th ICBL (Finland). After obtaining the PhD, she was awarded a competitive Research Fellowship in FCT-funded project EXPL/BIA-BFS/1034/2021 (2023) and in 2024 was hired as an INVITED ASSISTANT PROFESSOR in Biochemistry at Faculdade de Ciências, Universidade de Lisboa (FCUL), and the invitation was renewed for 2025. She supervised an ERASMUS+ Master student and currently supervises a Graduation Project at FCUL. To date, F. Santos has co-authored 12 international peer-reviewed articles and 2 international book chapters totalizing ca. 300 citations and an h-index: 10 (Scopus/Web of Science), 1 peer-reviewed national article, 1 national book chapter, 5 international conference abstracts in indexed journals, 13 oral communications (8 international) and 38 poster communications (16 international).
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Identification

Personal identification

Full name
Filipa Pedro Costa Santos

Citation names

  • Santos, Filipa C.
  • Santos, F.

Author identifiers

Ciência ID
BE16-3628-D73B
ORCID iD
0000-0001-9632-2300
Researcher Id
J-8627-2013
Scopus Author Id
55589595100

Email addresses

  • fpsantos@fc.ul.pt (Professional)

Addresses

  • Faculdade de Ciências da Universidade de Lisboa. Campo Grande, Ed C8, Piso 4, lab 8.4.67, 1749-016, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Biophysics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Intermediate (B1) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Spanish; Castilian Beginner (A1) Intermediate (B1) Elementary (A2) Intermediate (B1)
German Beginner (A1) Intermediate (B1) Beginner (A1) Intermediate (B1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2023/01/06
Concluded
 Bioquímica (Doutoramento)
Major in Biofísica Molecular
Universidade de Lisboa Faculdade de Ciências, Portugal
"Sphingolipid domains in the plasma membrane of fungal cells – Interplay with membrane proteins and antifungal resistance" (THESIS/DISSERTATION)
 Approved with Distinction
2011
Concluded
 Química Inorgânica Biomédica - Aplicações em Diagnóstico e Terapia (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Complexos de iões metálicos com interesse na terapia do Cancro: Estudos de interação com biomoléculas" (THESIS/DISSERTATION)
 15
2008
Concluded
 Bioquímica (Licenciatura)
Universidade de Évora, Portugal
"Caracterização da actividade da urease no solo e em <i>Fusarium oxysporum</i>" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2023/05 - 2023/12 Postdoc (Research) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Universidade de Lisboa Centro de Química Estrutural, Portugal
2020/07/01 - 2022/12/31 Researcher (Research) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/04/01 - 2020/06/30 Contracted Researcher (Research) FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2014/02/03 - 2020/01/31 Researcher (Research) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2016/02/01 - 2020 Contracted Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Departamento de Química e Bioquímica, Portugal
2013/01/01 - 2013/12/31 Researcher (Research) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2012/07/02 - 2012/10/31 Researcher (Research) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2011/07/01 - 2012/06/30 Researcher (Research) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2009/04/01 - 2009/09/30 Researcher (Research) Instituto de Biologia Experimental e Tecnológica, Portugal
Instituto de Biologia Experimental e Tecnológica, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2025/02/01 - Current Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2024/02/01 - 2024/07/31 Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal

Others

Category
Host institution 		Employer
2025/02/01 - Current Member of Centro de Química Estrutural Universidade de Lisboa Centro de Química Estrutural, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/05 - 2024/12 Integrated Member of Centro de Química Estrutural Universidade de Lisboa Centro de Química Estrutural, Portugal
Projects

Grant

Designation Funders
2023/05 - 2023/12 Role of sphingolipid hydroxylation in the organization of yeast plasma membrane and antifungal mode of action
EXPL/BIA-BFS/1034/2021
Research Fellow
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2020/04 - 2020/06 Consultoria e Análises de fluorescência
100AC9108_CC327
 FCiências.ID – Associação para a Investigação e Desenvolvimento de Ciências
2016/02 - 2020/01 Sphingolipid domains in the plasma membrane of fungal cells – Interplay with membrane proteins and antifungal resistance
SFRH/BD/108031/2015
PhD Student Fellow
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e Tecnologia
Concluded
2013/01 - 2013/12 Avaliação pré-clínica de potenciais fármacos de Ruténio na terapia do cancro
PTDC/QUI-QUI/118077/2010
 Ministério da Ciência Tecnologia e Ensino Superior
2011/07 - 2012/06 Complexos de Ruténio para aplicação anti-tumoral
PTDC/Qui-Qui/101187/2008
 Ministério da Ciência Tecnologia e Ensino Superior
2009/04 - 2009/09 Safewater - Development and validation of integrated drinking water treatment processes in Portugal and Norway
BD-Mic/12A/08
 Ministério da Ciência Tecnologia e Ensino Superior

Other

Designation Funders
2015/01/01 - 2015/12/31 Biophysical study of Neurospora crassa plasma membrane properties
PEst 2015-2020
UID/Multi/00612/2013
Researcher
Universidade de Lisboa Faculdade de Ciências, Portugal
Concluded
2014/02/01 - 2014/12/31 Biophysical study of Neurospora crassa plasma membrane in vivo; using stationary state and time resolved state fluorescence. Manipulation of mutants related to staurosporine metabolism.
PEstOE/ QUI/UI0612/20132014
Researcher
Universidade de Lisboa Faculdade de Ciências, Portugal
2012/07/02 - 2012/10/31 Characterization of the biophysical properties of the plasma membrane of Neurospora crassa by steadystate and timeresolved fluorescence techniques
PEst-OE/QUI/UI0612/2011
Researcher
Universidade de Lisboa Faculdade de Ciências, Portugal
Concluded
Outputs

Publications

Book chapter
  1. Sousa, Carla; Santos, Filipa C.; Bento-Oliveira, Andreia; Mestre, Beatriz; Silva, Liana C; DE ALMEIDA, R.F.M.. "Biophysical Analysis of Lipid Domains in Mammalian and Yeast Membranes by Fluorescence Spectroscopy". In Lipid Rafts: Methods in Molecular Biology, edited by Bieberich, Erhard, 247-269. Portugal: Springer US, 2021.
    Published • 10.1007/978-1-0716-0814-2_14
  2. DE ALMEIDA, RODRIGO F.M.; Santos, Filipa C.; Bento-Oliveira, Andreia; Marquês, Joaquim Trigo. "Membranas em ação? Nitrogénio em rede é campeão!". In Os Elementos em Ciências - uma viagem pela Tabela Periódica, edited by Mourato, Ana; Carvalho, A.P.; A.P. Carvalho; Ana P. Carvalho; Martins, Filomena; Pamplona, T.. Lisbon, Portugal: FCUL, 2020.
    Published
  3. Marquês, Joaquim Trigo; Antunes, Catarina A.C.; Santos, Filipa C.; DE ALMEIDA, RODRIGO F.M.. "Chapter 3 - Biomembrane Organization and Function". In Advances in Planar Lipid Bilayers and Liposomes, 65-96. Elsevier, 2015.
    Published • 10.1016/bs.adplan.2015.06.002
Conference abstract
  1. Santos, Filipa C.; Fernandes, Andreia S.; Videira, Arnaldo; Almeida, Rodrigo F.M. De. "Fungal Plasma Membrane Lipid Domains Alterations Upon Drug Exposure". Paper presented in 65th Biophysical Society Annual Meeting, 2021.
    Published
  2. Almeida, Rodrigo F.M. De; Marquês, Joaquim T.; Silva, Liana C.; Marinho, H. Susana; Corvo, M.L.; Fedeli, Francesca; Faria-Silva, Catarina; Santos, Filipa C.; Bento-Oliveira, Andreia. "Sphingolipid-Enriched Domains in Yeast: Biophysical Properties and Antifungal Interaction". Paper presented in 65th Biophysical Society Annual Meeting, 2021.
    Published • 10.1016/j.bpj.2020.11.517
  3. Bento-Oliveira, Andreia; Santos, Filipa C.; Marquês, Joaquim T.; Paulo, Pedro M.R.; Marinho, Susana; Almeida, Rodrigo F.M. de. "Impact of Sphingolipid Profile in Yeast Gel Domains and Membrane Compartments". Paper presented in 65th Biophysical Society Annual Meeting, 2021.
    Published • 10.1016/j.bpj.2020.11.526
  4. Santos, Filipa C.; Fernandes, Andreia S.; Videira, Arnaldo; DE ALMEIDA, RODRIGO F.M.. "Biophysical characterization of Neurospora crassa membrane and its sensitivity to Staurosporine". Paper presented in EBSA 2013, Lisboa, 2013.
    Published
  5. Santos, Telma C.; Matos, Cristina P.; Santos, Filipa C.; Corvo, M. Luisa; Garcia, M. Helena; Tomaz, A. I.; DE ALMEIDA, RODRIGO F.M.. "Interaction of new active Ruthenium anticancer agents with lipid bilayers". Paper presented in EBSA 2013, Lisboa, 2013.
    Published
Conference poster
  1. Santos, Filipa C.; Savarino, Renata; Gomes, Margarida; Leitão, Helena; Guimarães, Mafalda; Bento-Oliveira, Andreia; Marquês, Joaquim Trigo; DE ALMEIDA, RODRIGO F.M.. "The fungal membrane: biophysical impact of sphingolipid profile". Paper presented in Institute of Molecular Sciences (IMS) Open Day, 2024.
  2. Savarino, Renata; Santos, Filipa C.; Gomes, Margarida; Coelho, Beatriz; Leitão, Helena; Guimarães, Mafalda; Bento-Oliveira, Andreia; Marquês, Joaquim Trigo; DE ALMEIDA, R.F.M.. "How closely do sphingolipids and sterols interact in yeast plasma membrane?". Paper presented in 4th Chem & Biochem Students Meeting 2024, 2024.
  3. Savarino, Renata; Santos, Filipa C.; Gomes, Margarida; Coelho, Beatriz; Leitão, Helena; Guimarães, Mafalda; Bento-Oliveira, Andreia; Marquês, Joaquim Trigo; DE ALMEIDA, R.F.M.. "What happens in the yeast plasma membrane if sterol or sphingolipid profile changes?". Paper presented in CQE Days 2024, 2024.
  4. Santos, Filipa. "Sphingolipid domains in the plasma membrane of fungal cells - Interplay with antifungal resistance". Paper presented in 7ª Conferência Anual da redeSAÚDE, 2023.
  5. Bento-Oliveira, Andreia; Santos, Filipa C.; Marquês, Joaquim Trigo; Paulo, Pedro M. R.; Korte, Thomas; Herrmann, Andreas; Marinho, H. S.; DE ALMEIDA, R.F.M.. "Sphingolipid structure is crucial for the compartmentalization of membrane proton pump ATPase in yeast". Paper presented in 2nd Workshop on Sphingolipids in Health and Disease, 2022.
  6. Bento-Oliveira, Andreia; Santos, Filipa C.; Marquês, Joaquim Trigo; Paulo, Pedro M. R.; Korte, Thomas; Herrmann, Andreas; Marinho, H. S.; DE ALMEIDA, R.F.M.. "Impact of sphingolipid profile on yeast gel domains and membrane compartments". Paper presented in 2nd Chem&BioChem Postgraduate Students Meeting 2022, 2022.
  7. Santos, Filipa C.; Fernandes, Andreia S.; Videira, Arnaldo; DE ALMEIDA, RODRIGO F.M.. "Fungal plasma membrane lipid domains alterations upon drug exposure". Paper presented in 65th Biophysical Society Annual Meeting, 2021.
  8. Bento-Oliveira, Andreia; Santos, Filipa C.; Marquês, Joaquim Trigo; Paulo, Pedro M. R.; DE ALMEIDA, RODRIGO F.M.. "Impact of sphingolipid profile in yeast gel domains and membrane compartments". Paper presented in 65th Biophysical Society Annual Meeting, 2021.
  9. DE ALMEIDA, RODRIGO F.M.; Marquês, Joaquim Trigo; Silva, Liana C.; Marinho, H. Susana; Corvo, M. Luisa; Faria-Silva, Catarina; Santos, Filipa C.; Bento-Oliveira, Andreia. "Sphingolipid-enriched domains in yeast: biophysical properties and antifungal interaction". Paper presented in 65th Biophysical Society Annual Meeting, 2021.
  10. Bento-Oliveira, Andreia; Santos, Filipa C.; Marquês, Joaquim Trigo; Paulo, Pedro M. R.; Korte, Thomas; Herrmann, Andreas; Marinho, H. Susana; DE ALMEIDA, RODRIGO F.M.. "Gel domains and membrane compartments in yeast: impact of sphingolipid profile.". Paper presented in CQE Days Spring Meeting 2020, 2020.
  11. Bento-Oliveira, Andreia; Santos, Filipa C.; Marquês, Joaquim Trigo; Paulo, Pedro M. R.; Herrmann, Andreas; Marinho, Helena S.; DE ALMEIDA, RODRIGO F.M.. "The absence of Mannosyldiinositolphosphorylceramide in yeast plasma membrane affects sphingolipid-enriched domains and the membrane compartment of Pma1p". Paper presented in Dia de Investigação em Ciências 2019, 2019.
  12. Bento-Oliveira, Andreia; Marquês, Joaquim Trigo; Santos, Filipa C.; Antunes, Catarina A. C.; Marinho, Helena S.; DE ALMEIDA, RODRIGO F.M.. "Sphingolipid domains in yeast: Linking membrane biophysical properties and action of antifungal agents". Paper presented in CQE Days Spring Meeting 2019, 2019.
  13. Santos, Filipa C.; Marquês, Joaquim Trigo; Bento-Oliveira, Andreia; Starosta, Radoslaw; Herrmann, Andreas; Marinho, Helena S.; DE ALMEIDA, RODRIGO F.M.. "Tackling a possible relationship between fungal plasma membrane biophysical properties and antifungal sensitivity". Paper presented in FEBS Special Meeting 2019 - Sphingolipid Biology: Sphingolipids in Physiology and Pathology, 2019.
  14. Santos, Filipa C.; Lobo, Gerson M.; Fernandes, Andreia S.; Videira, Arnaldo; DE ALMEIDA, RODRIGO F.M.. "How do sphingolipid-enriched domains of fungal plasma membrane evolve upon a drug challenge?". Paper presented in 59th International Conference on the Bioscience of Lipids (ICBL 2018), 2018.
  15. DE ALMEIDA, RODRIGO F.M.; Marquês, Joaquim Trigo; Santos, Filipa C.; Marinho, Helena S.. "Sphingolipid headgroup impact on gel domains in Saccharomyces cerevisiae plasma membrane". Paper presented in X Iberian Spectroscopy Conference, 2018.
  16. Santos, Filipa C.; Fernandes, Andreia S.; Antunes, Catarina A. C.; Moreira, F. P.; Videira, Arnaldo; Marinho, Helena S.; DE ALMEIDA, RODRIGO F.M.. "Plasma membrane domains of filamentous fungi reorganize extensively during the lag phase". Paper presented in CQB-Day 2017, 2017.
  17. Antunes, Catarina A. C.; Moreira, F. P.; Santos, Filipa C.; Marquês, Joaquim Trigo; Bastos, André E. P.; Khmelinskaia, Alena; Malhó, Rui; et al. "Sphingolipid-enriched versus ergosterol-enriched domains in Saccharomyces cerevisiae". Paper presented in CQB-Day 2017, 2017.
  18. Marquês, Joaquim Trigo; Antunes, Catarina A. C.; Moreira, F. P.; Santos, Filipa C.; Viana, Ana S.; Marinho, Helena S.; DE ALMEIDA, RODRIGO F.M.. "Structural Stability and Molecular Organization of Yeast Sphingolipid-enriched Membrane Domains". Paper presented in CQB-Day 2017, 2017.
  19. Marquês, Joaquim Trigo; Antunes, Catarina A. C.; Moreira, Filipe P.; Santos, Filipa C.; Viana, Ana S.; Marinho, Helena S.; DE ALMEIDA, RODRIGO F.M.. "Structural Stability and Molecular Organization of Yeast Sphingolipid enriched Membrane Domains". Paper presented in Yeast Lipid Conference 2017, 2017.
  20. Antunes, Catarina A. C.; Moreira, Filipe P.; Santos, Filipa C.; Marquês, Joaquim Trigo; Bastos, André E. P.; Khmelinskaia, Alena; Marinho, Helena S.; DE ALMEIDA, RODRIGO F.M.. "Sphingolipid-enriched versus ergosterol-enriched domains in Saccharomyces cerevisiae". Paper presented in Yeast Lipid Conference 2017, 2017.
  21. Santos, Filipa; Fernandes, Andreia S.; Lobo, Gerson M.; Lange, Tobias; Videira, Arnaldo; DE ALMEIDA, RODRIGO F.M.. "Changes in the biophysical properties of the cell membrane in a chemotherapy resistance model". Paper presented in Encontro Ciência 2016, 2016.
  22. Santos, Filipa; Fernandes, Andreia S.; Antunes, Catarina A. C.; Moreira, Filipe P.; Videira, Arnaldo; Marinho, Helena S.; de Almeida, Rodrigo F. M.. "Reorganization of plasma membrane lipid domains in Neurospora crassa during conidial germination". Paper presented in CQB Day 2016, 2016.
  23. Santos, Filipa C.; Antunes, Catarina A. C.; Marquês, Joaquim Trigo; Fernandes, Andreia S.; Viana, Ana S.; Videira, Arnaldo; Marinho, Helena S.; de Almeida, Rodrigo F. M.. "Sphingolipid-dependent plasma membrane biophysical properties in antifungal drug action and resistance". Paper presented in CQB-Day 2015, 2015.
  24. de Sousa, Andreia D.; Santos, Telma C.; Santos, Filipa C.; Santos, M.S.; Corvo, M. Luisa; Garcia, M. Helena; Tomaz, A. I.; de Almeida, Rodrigo F. M.. "A membrane biophysics approach to the mechanism of action of new active Ruthenium anticancer compounds". Paper presented in CQB-Day 2015, 2015.
  25. Bagulho, A.; Vilas-Boas, Filipe; Pena, Andreia; Peneda, Catarina; Santos, Filipa C.; Jerónimo, Ana; de Almeida, Rodrigo F. M.; Real, Carla. "H2O2 Consumption rate and redox signaling in Endothelial cells is modulated by extracellular matrix". Paper presented in CQB-Day 2015, 2015.
  26. Santos, Filipa C.; Fernandes, Andreia S.; Videira, Arnaldo; de Almeida, Rodrigo F. M.. "Membrane domain reorganization in Neurospora crassa during growth and Staurosporine-induced programmed cell death". Paper presented in CQB-Day 2014, 2014.
  27. Santos, Filipa C.; Fernandes, Andreia S.; Videira, Arnaldo; de Almeida, Rodrigo F. M.. "Biophysical characterization of Neurospora crassa membrane and its sensitivity to Staurosporine". Paper presented in EBSA 13 - 9th European Biophysics Congress, 2013.
  28. Santos, Telma C.; Matos, Cristina P.; Santos, Filipa C.; Corvo, M. Luisa; Garcia, M. Helena; Tomaz, A. I.; de Almeida, Rodrigo F. M.. "Interaction of new active Ruthenium anticancer agentes with lipid bilayers". Paper presented in EBSA 13 - 9th European Biophysics Congress, 2013.
  29. Santos, Telma C.; Matos, Cristina P.; Santos, Filipa C.; Garcia, M. Helena; Tomaz, A. I.; de Almeida, Rodrigo F. M.. "Mechanisms of action of metallodrugs in cancer therapy: probing the interaction of new active Ruthenium agents with lipid bilayers". Paper presented in 1st Research in Health Sciences, 2013.
  30. Santos, Filipa C.; Rojas, Oscar L.; Santos, Fernando J.V.; de Almeida, Rodrigo F. M.; Garcia, M. Helena; Tomaz, A. I.. "Ru(II) polypyridyl antitumor complexes: Interaction with DNA and human serum albumin". Paper presented in ICOMC 2012, 2012.
  31. Santos, Filipa C.; Rojas, Oscar L.; Santos, Fernando J.V.; de Almeida, Rodrigo F. M.; Garcia, M. Helena; Tomaz, A. I.. "DNA as a potential biological target for new Ruthenium(II) polypyridyl anti-tumor complexes". Paper presented in ISABC 11, 2011.
  32. Rojas, Oscar L.; Santos, Filipa C.; Brito, M. José; Marques, Fernanda; Robalo, M. Paula; de Almeida, Rodrigo F. M.; Garcia, M. Helena; Tomaz, A. I.. "New Ruthenium antitumor complexes: synthesis, anti-proliferative activity and interaction with human albumin". Paper presented in ISABC 11, 2011.
  33. Santos, Filipa C.; Rojas, Oscar L.; Santos, Fernando J.V.; de Almeida, Rodrigo F. M.; Garcia, M. Helena; Tomaz, A. I.. "DNA as a potential biological target for new ruthenium(II) complexes". Paper presented in 4th European Conference on Chemistry for Life Sciences (4ECCLS), 2011.
  34. Rojas, Oscar L.; Santos, Filipa C.; Brito, M. José; Marques, Fernanda; Robalo, M. Paula; de Almeida, Rodrigo F. M.; Garcia, M. Helena; Tomaz, A. I.. "New ruthenium(II) polypyridyl complexes as potential anti-tumor agents: synthesis, characterization and anti-proliferative activity". Paper presented in 4th European Conference on Chemistry for Life Sciences (4ECCLS), 2011.
  35. Santos, Filipa C.; Rojas, Oscar L.; Santos, Fernando J.V.; de Almeida, Rodrigo F. M.; Garcia, M. Helena; Tomaz, A. I.. "New RuII polypyridyl antitumor complexes: interaction with DNA and human albumin". Paper presented in XXII Encontro Nacional SPQ, 2011.
  36. Santos, Filipa C.; Rojas, Oscar L.; Santos, Fernando J.V.; de Almeida, Rodrigo F. M.; Garcia, M. Helena; Tomaz, A. I.. "Estudo da interacção do DNA com complexos RuII com interesse na terapia do Cancro". Paper presented in 1º Encontro de Alunos do DQB-FCUL, 2011.
  37. Rojas, Oscar L.; Santos, Filipa C.; Brito, M. José; Marques, Fernanda; Robalo, M. Paula; de Almeida, Rodrigo F. M.; Garcia, M. Helena; Tomaz, A. I.. "Desenvolvimento de complexos de RuII para aplicações anti-tumorais". Paper presented in 1º Encontro de Alunos do DQB-FCUL, 2011.
  38. Santos, Filipa C.; Martins, M. Rosário; Cruz-Morais, Júlio. "Urease activity in soil and in Fusarium oxysporum cultures". Paper presented in XVI Congresso Nacional de Bioquímica, 2008.
Journal article
  1. Santos FC; Costa PJ; Garcia MH; Morais TS. "Binding of RuCp complexes with human apo-transferrin: fluorescence spectroscopy and molecular docking methods.". Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine (2021): http://europepmc.org/abstract/med/34155581.
    10.1007/s10534-021-00325-w
  2. Starosta, Radoslaw; Santos, Filipa C.; de Almeida, Rodrigo F.M.. "Human and bovine serum albumin time-resolved fluorescence: Tryptophan and tyrosine contributions, effect of DMSO and rotational diffusion". Journal of Molecular Structure 1221 (2020): 128805. http://dx.doi.org/10.1016/j.molstruc.2020.128805.
    10.1016/j.molstruc.2020.128805
  3. Santos, Filipa C.; Marquês, Joaquim Trigo; Bento-Oliveira, Andreia; DE ALMEIDA, RODRIGO F.M.. "Sphingolipid-enriched domains in fungi". FEBS Letters 594 22 (2020): 3698-3718. https://doi.org/10.1002/1873-3468.13986.
    10.1002/1873-3468.13986
  4. Bento-Oliveira, Andreia; Santos, Filipa C.; Marquês, Joaquim Trigo; Paulo, Pedro M. R.; Korte, Thomas; Herrmann, Andreas; Marinho, H. Susana; de Almeida, Rodrigo F. M.. "Yeast Sphingolipid-Enriched Domains and Membrane Compartments in the Absence of Mannosyldiinositolphosphorylceramide". Biomolecules 10 6 (2020): 871. http://dx.doi.org/10.3390/biom10060871.
    Published • 10.3390/biom10060871
  5. DE ALMEIDA, RODRIGO F.M.; Santos, Filipa C.; Marycz, Krzysztof; Alicka, Michalina; Krasowska, Anna; Suchodolski, Jakub; Panek, Jaroslaw J.; Jezierska, Aneta; Starosta, Radoslaw. "New diphenylphosphane derivatives of ketoconazole are promising antifungal agents". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-52525-7.
    10.1038/s41598-019-52525-7
  6. Santos, Filipa; Lobo, Gerson M.; Fernandes, Andreia S.; Videira, Arnaldo; DE ALMEIDA, RODRIGO F.M.. "Changes in the Biophysical Properties of the Cell Membrane Are Involved in the Response of Neurospora crassa to Staurosporine". Frontiers in Physiology - Membrane Physiology and Membrane Biophysics 9 1375 (2018): 1-12. https://www.frontiersin.org/articles/10.3389/fphys.2018.01375/full.
    Open access • Published • 10.3389/fphys.2018.01375
  7. Santos, Filipa C.; Fernandes, Andreia S.; Antunes, Catarina A. C.; Moreira, Filipe P.; Videira, Arnaldo; Marinho, Helena S.; DE ALMEIDA, RODRIGO F.M.. "Reorganization of plasma membrane lipid domains during conidial germination.". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1862 2 (2017): 156-166. http://dx.doi.org/10.1016/j.bbalip.2016.10.011.
    Published • 10.1016/j.bbalip.2016.10.011
  8. Côrte-Real, Leonor; Robalo, M. Paula; Marques, Fernanda; Nogueira, Guilherme; Avecilla, Fernando; J.L. Silva, Tiago; C. Santos, Filipa; et al. "The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds". Journal of Inorganic Biochemistry 150 (2015): 148-159. http://dx.doi.org/10.1016/j.jinorgbio.2015.06.015.
    10.1016/j.jinorgbio.2015.06.015
  9. Santos, Filipa. "The extracellular matrix modulates H2O2 degradation and redox signaling in endothelial cells". Redox Biology (2015):
    10.1016/j.redox.2015.09.006
  10. Morais, T.S.; Santos, F.C.; Jorge, T.F.; Côrte-Real, L.; Madeira, P.J.A.; Marques, F.; Robalo, M.P.; et al. "New water-soluble ruthenium(II) cytotoxic complex: Biological activity and cellular distribution". Journal of Inorganic Biochemistry 130 1 (2014): 1-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885498325&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2013.09.013
  11. Morais, T.S.; Santos, F.; Côrte-Real, L.; Marques, F.; Robalo, M.P.; Madeira, P.J.A.; Garcia, M.H.. "Biological activity and cellular uptake of [Ru(¿5-C 5H5)(PPh3)(Me2bpy)][CF 3SO3] complex". Journal of Inorganic Biochemistry 122 (2013): 8-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873704110&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2013.01.011
  12. Morais, T.S.; Santos, F.C.; Corte-Real, L.; Garcia, M.H.. "Exploring the effect of the ligand design on the interactions between [Ru(¿5-C5H5)(PPh3)(N,O)][CF 3SO3] complexes and human serum albumin". Journal of Inorganic Biochemistry 129 (2013): 94-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884952269&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2013.09.008
  13. Martins, M. Rosário; Santos, Filipa C.; Candeias, P.; Cruz-Morais, Júlio. "Effect of temperature, pH and Hg2+ and Pb2+ traces in dehydrogenase and urease activities of a soil from Évora region". Revista de Ciências Agrárias 33 1 (2010): 314-322.
    Published
Thesis / Dissertation
  1. "Sphingolipid domains in the plasma membrane of fungal cells – Interplay with membrane proteins and antifungal resistance". PhD, Universidade de Lisboa Faculdade de Ciências, 2023. http://hdl.handle.net/10451/57798.
  2. Santos, Filipa C.. "Complexos de iões metálicos com interesse na terapia do Cancro: Estudos de interação com biomoléculas". Master, Universidade de Lisboa Faculdade de Ciências, 2011. https://repositorio.ul.pt/handle/10451/8705.
  3. Santos, Filipa C.. "Caracterização da actividade da urease no solo e em Fusarium oxysporum". Degree, Universidade de Évora, 2008.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11/14 Sphingolipid domains in the plasma membrane of fungal cells - Interplay with antifungal resistance 7ª Conferência Anual da redeSAÚDE
Rede Saúde Universidade de Lisboa (Lisboa, Portugal)
2022/06 Targeting yeast sphingolipids by the antifungal polyene Nystatin YLC 2022 – Yeast Lipid Conference
Chalmers University of Technology (Gothenburg, Sweden)
2022/06 Impact of sphingolipid hydroxylation and polar headgroup on yeast lipid domains and membrane protein compartments YLC 2022 – Yeast Lipid Conference
Chalmers University of Technology (Gothenburg, Sweden)
2021/12/12 Impact of Sphingolipid Profile in Yeast Gel Domains and Membrane Compartments Webinar Series in Sphingolipids Biology: PhD Students contest
2019/05 Sphingolipid headgroup impact on gel domains in Saccharomyces cerevisiae plasma membrane FEBS Special Meeting 2019 – Sphingolipid Biology: Sphingolipids in Physiology and Pathology
FEBS (Cascais, Portugal)
2018/07 Adaptation of fungal plasma membrane to a drug challenge Xth Iberian Spectroscopy Conference
Faculdade de Ciências Universidade de Lisboa (Lisboa, Portugal)
2018/07 Ruthenium complexes as cancer metallodrugs 12th Inorganic and Bioinorganic Chemistry Conference
Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)
2017/12 Ruthenium complexes and their potential in cancer therapy 2nd International Caparica Christmas Congress on Translational Chemistry
Caparica (Almada, Portugal)
2017/05/31 Plasma membrane domains of filamentous fungi reorganize extensively during the lag phase CQB-Day 2017
Centro de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa (Lisboa, Portugal)
2014/10 Changes in the biophysical properties of the cell membrane in a chemotherapy resistance model Jornadas I CBIOS
Universidade Lusófona (Lisboa, Portugal)
2011/07 Synthesis and cytotoxicity of new Ruthenium(II) complexes for antitumor application XXII Encontro Nacional SPQ
Braga (Braga, Portugal)
2008/07 Dehydrogenase and Urease activities of a soil from Évora region III Congreso Ibérico de la Ciência del Suelo
Universidade de Évora (Évora, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024 - Current Influência da hidroxilação de esfingolípidos na organização membranar e no mecanismo de ação de antifúngicos
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2024/10/01 - 2024/12/31 Research fellowship of a ERASMUS Master student under the project: Impact of the sphingolipid profile on the biophysical properties of the yeast plasma membrane.
Co-supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2014 Fluorescence spectroscopy study of plasma membrane domains in the filamentous fungi Neurospora crassa; ERASMUS Master
Co-supervisor of Tobias Lange
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/05/06 - 2019/05/10 FEBS Special Meeting - Sphingolipid Biology: Sphingolipids in Physiology and Pathology (2019/05/06 - 2019/05/10)
Conference (Other)
2017/02/09 - 2017/02/09 Membro da Organização do “Chem&BioChem Postgraduate Students Meeting 2017” (2017/02/09 - 2017/02/09)
Conference (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Ciências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/05/03 - 2023/05/03 From yeast membrane to antifungals, Open Day FCUL
Other
 Open Day FCUL
Universidade de Lisboa Faculdade de Ciências, Portugal
2017/11/23 - 2017/11/23 Science & Technology Week promoted by the Ciência Viva Agency
Other
 Science & Technology Week
Universidade de Lisboa Faculdade de Ciências, Portugal
2017/05/09 - 2017/05/09 Visit of the Portuguese Asperger Syndrome Association: APSA to the Molecular Biophysics laboratory
Other
 Visit of the Portuguese Asperger Syndrome Association: APSA to the Molecular Biophysics laboratory
Universidade de Lisboa Faculdade de Ciências, Portugal
2017/05/03 - 2017/05/03 Molecular Biophysics OpenLab
Other
 Open Day FCUL
Universidade de Lisboa Faculdade de Ciências, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/09/30 Estudo das interações moleculares e do modo de ação de fármacos em sistemas modelo de membranas biológicas
(Thesis) Main arguer
 Francisco Correia (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/09/29 Influência da hidroxilação de esfingolípidos na organização membranar e no mecanismo de ação de antifúngicos
(Thesis) Main arguer
 SANDRA CATARINA REBELO DIAS (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal

Association member

Society Organization name Role
2016 - Current Biophysical Society Regular Associate
2014/10/02 - Current European Society of Clinical Microbiology and Infectious Diseases Full Membership
2012 - Current Sociedade Portuguesa de Biofísica (SPBf) Effective Associate
2011/04/26 - Current Sociedade Portuguesa de Química (SPQ) Effective Associate
2008 - Current Associação Nacional de Bioquímicos (ANBIOQ) Student Associate
2008 - Current Sociedade Portuguesa de Bioquímica (SPB) Effective Associate

Committee member

Activity description
Role 		Institution / Organization
2018/07/09 - 2018/07/11 X Iberian Spectroscopy Conference/ XXVI National Spectroscopy Meeting
Member
 Universidade de Lisboa Faculdade de Ciências, Portugal
2017 - 2017 Membro do Comité Pedagógico (Bioquímica, 3º ciclo)
Member
 Universidade de Lisboa Faculdade de Ciências, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/01/09 - 2019/01/29 Teaching staff of the Pharmaceutical Biophysics Course under the FCT PhD Programme Medicines and Pharmaceutical Innovation Universidade de Lisboa Faculdade de Farmácia, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2023/04 - Current Archives of Microbiology Springer Nature
2013/06 - Current Plos One

Mentoring / Tutoring

Topic Student name
2024 - 2024 Mitch Bruyneel
2023 - 2023 Helena Leitão
2017 - 2018 Andreia Bento-Oliveira
2015 - 2016 Filipe Moreira
2015 - 2016 Gerson Lobo
2014 - 2015 Andreia Sousa
2012 - 2013 Telma Cordeiro Santos
2012 - 2013 Catarina Antunes
Distinctions

Award

2022 Best oral communication
Federation Of European Microbiological Societies, Netherlands

Other distinction

2018 YTF, Youth Travel Fund to attend FEBS Practical course “Microspectroscopy: Functional Imaging of Biological Systems”
Federation of European Biochemical Societies, United Kingdom
2018 Waiver Registration Fee to attend 59th International Conference on the Bioscience of Lipids
European Biophysical Societies' Association (EBSA), United Kingdom
2011 ESF Student Grant, Scientific Committee of the 4th European Conference on Chemistry for Life Sciences
European Science Foundation, France