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Passionate, determined, and enthusiastic from an early age, I realised that curiosity and eagerness for knowledge are my fuel. Scientific Questions: Yes/No Why/Why not With my background in biotechnology and biochemistry, I am able to know if works experimentally, allying my knowledge in Computational Chemistry I can now determine why, make predictions, and design solutions. I seek to combine my strengths in collaboration with a dynamic team that allows me to grow and be part of the world's evolution.
Identification

Personal identification

Full name
Sónia Filipa Gomes dos Santos

Citation names

  • Santos, Sónia
  • Sónia F G Santos
  • Sónia F Santos

Author identifiers

Ciência ID
BE17-4192-3F2B

Email addresses

  • sonia.santos@northumbria.ac.uk (Professional)
  • soniafgsantos@gmail.com (Professional)
  • sonia17051989@gmail.com (Personal)

Addresses

  • 10 Longhorn Close, NE6-1XJ, Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom (Professional)

Websites

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
French Intermediate (B1) Intermediate (B1) Elementary (A2) Intermediate (B1) Elementary (A2)
Spanish; Castilian Elementary (A2) Upper intermediate (B2) Elementary (A2) Upper intermediate (B2)
Education
Degree Classification
2020/10 - 2023/09
Ongoing
 Computational Chemistry (Doctor of Philosophy)
Northumbria University, United Kingdom

Hub for Biotechnology in the Built Environment , Portugal
2020/04/14 - 2020/07/06
Ongoing
 Introduction to Java programming (Outros)
Universidade de Coimbra, Portugal
2017/10/06 - 2019/09/13
Concluded
 Biochemistry (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Estudos de dinâmica molecular em endonucleases de restrição do tipo 2 de raro corte- Estudo da enzima SgrAI " (THESIS/DISSERTATION)
2017/02 - 2017/04
Concluded
 Introduction to Computers in Chemistry (Outros)
Universidade de Coimbra, Portugal
2007 - 2012/10/18
Concluded
 Biotechnology (Licenciatura)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
"Extraction of RNA from Triticum aestivum L., Introduction to ereal-time PCR with Triticum aestivum L., Tissue culture in Bog Pine, Somatic embryogenesis in conifers, Immunolocalization of PIN proteins in Pisum saticum L. and SSR Markers PCR. " (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2020/06/01 - 2020/09/30 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/02/12 - 2013/05/15 Research Trainee (Research) Centro de Estudos de Recursos Naturais Ambiente e Sociedade, Portugal
Centro de Estudos de Recursos Naturais Ambiente e Sociedade, Portugal
2012/07/01 - 2012/09/30 Research Trainee (Research) Mendelova Univerzita v Brne, Czech Republic
Mendelova Univerzita v Brne, Czech Republic

Others

Category
Host institution 		Employer
2015/08/10 - 2020/01/27 Technique of complementary diagnostic exams in Ophthalmology Centro Cirurgico de Coimbra, Portugal
Projects

Grant

Designation Funders
2020/10/01 - 2023/09/30 Computational Enzyme design for the development of biotechnology to create a new generation of living buildings
ET20/HLS/APP/SINGH
PhD Student Fellow
Northumbria University Faculty of Health and Life Sciences, United Kingdom
 UK Research and Innovation
Ongoing
2020/06/01 - 2020/09/30 Rational design of endonucleases
IF/01272/2015
Research Fellow
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia

Other

Designation Funders
2012/02 - 2013/05 Geranium Robertianum L. antioxidant properties
PTDC/AAC-CLI/098308/2008
PTDC/AAC-CLI/118092/2010
PEst-OE/AGR/UI0681/CNC/CEF/2011
Extracurricular Internship
Centro de Estudos de Recursos Naturais Ambiente e Sociedade, Portugal

Universidade de Coimbra Departamento de Química, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal
2011/03 - 2011/05 Cannabinoid effect on an increased intraocular pressure model
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Extracurricular Internship
Associação para a Investigação Biomédica e Inovação em Luz e Imagem, Portugal
Outputs

Publications

Conference abstract
  1. Septiyani, Retnosyari; Wibowo, Condro. "Antioxidant properties of Geranium robertianum L.". Paper presented in European Journal of Clinical Investigation, 2019.
    10.1063/1.5097503
Conference poster
  1. Santos, Sónia. "The O-Demethylation of 4-alkylguaiacols by Cytochrome P450 AgcAEP4". Paper presented in 8th Annual CCPBiosim Conference- Frontiers in Biomolecular Simulations 2022, 2022.
  2. Santos, Sónia; Singh, Warispreet. Corresponding author: Singh, Warispreet. "The O-Demethylation of 4-alkylguaiacols by Cytochrome P450 AgcAEP4". Paper presented in NextGenBiocat- Next Generation Biocatalysis an International Young Investigator Symposium, 2022.
  3. Santos, Sónia; Singh, Warispreet. "Reaction mechanism of Mevalonate diphosphate decarboxylases using QM/MM". Paper presented in MGMS Young Modellers Forum 2021, 2021.
Journal article
  1. Sónia F. G. Santos; Rajesh Reddy Bommareddy; Gary Black; Warispreet Singh; Meilan Huang. "The substrate specificity in the O-demethylation of 4-alkylguaiacols by cytochrome P450 AgcAP450". Catalysis Science & Technology 13 7 (2023): 2070-2079. http://dx.doi.org/10.1039/d3cy00123g.
    10.1039/d3cy00123g
  2. Sónia Filipa Gomes dos Santos; Warispreet Singh; Santos SFG; Paul James; Gary Black; Meilan Huang; Kshatresh Dutta Dubey. "Single-Site Mutation Induces Water-Mediated Promiscuity in Lignin Breaking Cytochrome P450GcoA.". ACS omega (2022): https://europepmc.org/articles/PMC9219061.
    10.1021/acsomega.2c00524
  3. Figueiredo, Pedro R.; Santos, Sónia F. G.; Almeida, Beatriz C.; Simões, Isaura; Carvalho, Alexandra T. P.. "Introduction of a Glycine Linker Connecting the Heavy and Light Chains in Synthetic Cardosin B-Derived Rennet Changes the Specificity of Subpocket S3'". The Journal of Physical Chemistry B 125 17 (2021): 4368-4374. http://dx.doi.org/10.1021/acs.jpcb.1c01826.
    10.1021/acs.jpcb.1c01826
  4. Helena Ramos; Juliana Calheiros; Joana Almeida; Valentina Barcherini; ´Sónia Santos; Alexandra T. P. Carvalho; Maria M. M. Santos; Lucília Saraiva. "SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner". International Journal of Molecular Sciences (2020): https://www.mdpi.com/1422-0067/21/2/596.
    10.3390/ijms21020596
Preprint
  1. Sónia Filipa Gomes dos Santos; Warispreet Singh; Sonia F Santos; Shalini Yadav; Gary Black; Vera Krewald; Kshatresh Dutta Dubey. "Substrate Conformation Masquerades Two different Oxidants in Aromatic C-H and C-F bond activation by Heme-dependent Tyrosine Hydroxylase". 2022. http://dx.doi.org/10.26434/chemrxiv-2022-25g47.
    10.26434/chemrxiv-2022-25g47
Thesis / Dissertation
  1. Santos, Sónia. "Estudos de Dinâmica Molecular em endonucleases de restrição do tipo 2 de raro corte". Master, 2019.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/11/25 QM/MM study on aromatic hydroxylation performed by the P450 Cinnamate-4-Hydroxylase MGMS Young Modellers Forum 2022
Molecular Graphics and Modelling Society (Oxford, United Kingdom)
2022/07/15 The O-demethylation of 4-alkylguaiacols by Cytochrome P450 AgcAEP4
Chemistry and Biochemistry Department of Faculdade de Ciências da Universidade de Lisboa (FCUL) (Lisbon, Portugal)
2021/02/10 Breakdown of biomass using enzyme engineering PhD talks
HBBE (Newcastle upon Tyne, United Kingdom)
2020/02/27 “Hands-on session: Molecular Dynamics” PDBEB Courses 2019/2020 - Computational Biology
(Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2018/10/01 - Current 2018 MIT Portugal Annual Conference
Conference
 Annual Conference of the MIT Program
2011/11/15 - Current Cell/Tissue Culture Workshop
Conference
2010/04/15 - Current Animal testing Workshop
Conference
2022/09/10 - 2023/01/10 Programming with Python
Workshop
 Programming with Python
2022/06/09 - 2022/06/10 Using MD Analysis and ML in real-life MD workflows
Workshop
 MD Analysis and Machine Learning workshop
The University of Edinburgh, United Kingdom

CCPBioSim- Collaborative Computational Project for Biomolecular Simulation, United Kingdom
2020/10/02 - 2020/10/09 Biomolecular simulations workshops and seminars
Workshop
 CCPBiosim Training Week 2020
CCPBioSim- Collaborative Computational Project for Biomolecular Simulation, United Kingdom
2020/09/19 - 2020/09/19 Latest advances in innovative therapies
Conference
 2nd CIBB Innovative Therapies Retreat 2020
Universidade de Coimbra, Portugal
2012/09/11 - 2012/09/13 Applied Plant Biotechnology Conference

Association member

Society Organization name Role
2021 - Current IChemE -Advancing Chemical Engineering Worldwide Affiliate member/ Postgraduate student

Mentoring / Tutoring

Topic Student name
2022/06/01 - 2022/09/15 Master's Project- Unspecific Peroxydases in Lignin Breakdown Kaustubh Mane
Distinctions

Award

2022 Best oral communication- "The O-demethylation of 4-alkylguaiacols by Cytochrome P450 AgcAEP4"