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Leonor Amaral Silva Ferreira, completed her master thesis in Toxicologia e Contaminação Ambientais in 2018 by Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar and Faculdade de Ciências da Universidade do Porto and a bachelor's degree in Ciências e Tecnologia do Ambiente in 2016 by Universidade do Porto Faculdade de Ciências. Currently is a contracted researcher in Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental. Published 1 article and participated in over 6 events with poster presentations and oral communications. Works in the area of Natural sciences with emphasis on Biological Sciences, Medical and Health Sciences and Medical Biotechnology. In her curriculum Ciência Vitae the most frequent terms in the context of scientific and technological output are: cyanobacteria; anticancer natural compounds; 3D tumor cell model; multidrug resistance; .
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Identification

Personal identification

Full name
Leonor Amaral Silva Ferreira
Date of birth
1995/08/10
Gender
Female

Citation names

  • Ferreira, Leonor

Author identifiers

Ciência ID
BF1C-1689-38BB
ORCID iD
0000-0003-2337-3152

Email addresses

  • lferreira@ciimar.up.pt (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences
  • Medical and Health Sciences - Medical Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2022/10 - 2026
Ongoing
 Biotecnologia Marinha e Aquacultura (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
"Cyanobacteria and drug discovery: advances and novel approaches to exploit the prolific production of anticancer compounds" (THESIS/DISSERTATION)
2016 - 2018
Concluded
 Toxicologia e Contaminação Ambientais (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
"Bioactivity screening of cyanobacteria for the isolation of novel anticancer compounds using 2D and 3D cell culture models" (THESIS/DISSERTATION)
 18
2013 - 2016
Concluded
 Ciências e Tecnologia do Ambiente (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
 14
Affiliation

Science

Category
Host institution 		Employer
2022/01/01 - 2023/02/28 Contracted Researcher (Research) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2018/12/03 - 2021/12/31 Researcher (Research) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Others

Category
Host institution 		Employer
2017/09/01 - 2018/11/26 Master's thesis student - Bioactivity screening of cyanobacteria for the isolation of anticancer compounds using 2D and 3D cell culture models Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2016/02/15 - 2016/07/15 Bachelor's degree curricular internship - Implementation of the OECD 301F method and study of the biodegradability of the pharmaceutical Bezafibrate Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
Projects

Grant

Designation Funders
2018/07/01 - 2021/12/31 Uncovering the cyanobacterial chemical diversity: the search for novel anticancer compounds
PTDC/MED-QUI/30944/2017
Research Fellow
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing

Contract

Designation Funders
2022/11/01 - Current Microbial Resource Research Infrastructure - MIRRI
312251
Research Technician Fellow
European Commission
Ongoing
Outputs

Publications

Conference abstract
  1. Ferreira, Leonor; Sousa, Maria Lígia; Preto, Marco; Morais, João; Silva, Raquel; Urbatzka, Ralph; Vasconcelos, Vitor; Reis, Mariana. "Combination of metabolomic tools and bioactivity screening as a strategy to find hit anticancer compounds from a library of cyanobacterial fractions". Paper presented in Blue Think Conference 2021, Matosinhos, 2021.
  2. Sandra Pereira; Leonor Ferreira; Catarina Gonçalves; Vitor Vasconcelos; Mariana Reis; Joana Reis Almeida. "Cyanobacterial bioactive nucleosides with antifouling properties". Paper presented in 1st International Congress of Biotechnology and Bioengineering and 5th Peruvian Congress Biotechnology and Bioengineering, 2021.
Conference paper
  1. Leonor Ferreira; Maria Ligía Sousa; Tiago Ribeiro; João Morais; Abel Forero; Raquel Castelo-Branco; Pedro N. Leão; et al. "Uncovering the Cyanobacterial Chemical Diversity: The Search for Novel Anticancer Compounds". 2022.
    10.3390/blsf2022014049
  2. Leonor Ferreira; João Morais; Vitor Vasconcelos; Mariana Reis. "Discovery of a Novel Potent Cytotoxic Compound from Leptothoe sp.". 2022.
    10.3390/blsf2022014046
  3. Sandra Pereira; Leonor Ferreira; Catarina Gonçalves; Vitor Vasconcelos; Mariana Reis; Joana R. Almeida. "Cyanobacteria as a Source of New Antifouling Sustainable Solutions". 2022.
    10.3390/blsf2022014037
Conference poster
  1. Ferreira, Leonor; Ana Catarina Fonseca; João Morais; Ralph Urbatzka; Vitor Vasconcelos; Mariana Reis. "Synergistic approaches in natural products discovery: metabolomic, genomic, and bioactivity- guided isolation of new compounds from the cyanobacterium Phormidium sp. LEGE 15488". Paper presented in International Congress on Natural Products Research, Krakow, 2024, July 13-17, 2024.
  2. Ferreira, Leonor; Ana Catarina Fonseca; João Morais; Ralph Urbatzka; Vitor Vasconcelos; Mariana Reis. "The cyanobacterium Phormidium sp. LEGE 15488 as a producer of new bioactive compounds for obesity treatment". Paper presented in 8th Congress of the International Society of Applied Phycology, June 16 to 21, 2024, Porto, Portugal, 2024.
  3. Flávia Rodrigues; Ferreira, Leonor; Clara Grosso; Mariana Reis; Vitor Vasconcelos; Ricardo Ferraz; Rosário Martins. "Screening the potential of cyanobacteria towards neurodegenerative diseases.". Paper presented in 6th Meeting of Medicinal Biotechnology. 17 May 2024. Porto. Portugal., 2024.
  4. Flávia Rodrigues; Ferreira, Leonor; Clara Grosso; Mariana Reis; Vitor Vasconcelos; Ricardo Ferraz; Rosário Martins. "Neuroprotective effects of cyanobacteria extracts.". Paper presented in 17th Edition of Investigação Jovem da Universidade do Porto (IJUP). 08-10 May 2024. Porto. Portugal., 2024.
  5. Ferreira, Leonor; Maria Ligia Sousa; João Morais; Vitor Vasconcelos; Ralph Urbatzka; Mariana Reis. "Bioactive compounds from cyanobacteria: the importance of library screening". Paper presented in Ciência 2023, 2023.
  6. Ferreira, Dora; Ferreira, Leonor; Urbatzka, Ralph; Almeida, Joana; Vasconcelos, Vítor; Morais, Rui; Reis, Mariana. Corresponding author: Reis, Mariana. "Revealing the biosynthetic potential of Leptothoe sp. through OSMaC strategies". Paper presented in 16° Edição do Encontro de Investigação Jovem da Universidade do Porto, 2023.
  7. Maria Lígia Sousa; Ferreira, Leonor; Abel Forero; Castelo-Branco, Raquel; Gabriella Spengler; Carlos Jiménez; Jaime Rodriguez; et al. Corresponding author: Reis, Mariana. "Discovery and isolation of new cyanobacterial salicyl capped-thiazol(in)e siderophores". Paper presented in 7th Iberian Congress on Cyanotoxins/3rd Iberoamerican Congress on Cyanotoxins, 2022.
  8. Ferreira, Leonor; Morais, João; Marco Preto; Silva, Raquel; Sousa, Maria Lígia; Urbatzka, Ralph; Vasconcelos, Vitor; Reis, Mariana. "Exploring a cyanobacterial fractions library for its anticancer potential using metabolomics". Paper presented in XII European Conference on Marine Natural Products, 2021.
  9. Sandra Pereira; Leonor Ferreira; Catarina Gonçalves; Vitor Vasconcelos; Mariana Reis; Joana Reis Almeida. "Antifouling bioactive nucleosides from marine cyanobacteria". Paper presented in XII European Conference on Marine Natural Products, 2021.
  10. Ferreira, Leonor; Morais, João; Preto, Marco; Silva, Raquel; Sousa, Maria Lígia; Urbatzka, Ralph; Vasconcelos, Vitor; Reis, Mariana. "Evaluation of the Anticancer Potential of a Library of Cyanobacterial Fractions by Combining Metabolomic Tools and Bioactivity Screening.". Paper presented in Vanguards of Natural Product Research 2021, 2021.
  11. Sousa, Maria Lígia; Ferreira, Leonor; Raquel Castelo-Branco; Vasconcelos, Vítor; Ralph Urbatzka; Leão, Pedro N.; Reis, Mariana. Corresponding author: Reis, Mariana. "New cyanobacterial phenolate-type siderophores with anticancer activity against cancer multicellular spheroid cultures". Paper presented in Vanguards of Natural Product Research 2021, 2021.
  12. Sandra Pereira; Leonor Ferreira; Vitor Vasconcelos; Mariana Reis; Joana Reis Almeida. "A bioguided approach on the discovery of nucleosides with antifouling properties". Paper presented in Blue Think Conference 2021, 2021.
  13. Ferreira, Leonor; Scharfenstein, Hugo; Krempel, Tim; Morais, João; Preto, Marco; Vasconcelos, Vitor; Urbatzka, Ralph; Reis, Mariana. "Cyanobacteria as a Source of Anticancer Compounds". Paper presented in XVI International Symposium on Marine Natural Products|XI European Conference on Marine Natural Products, 2019.
    https://doi.org/10.3390/md18010040
  14. Ferreira, Leonor; Scharfenstein, Hugo; Krempel, Tim; Morais, João; Preto, Marco; Vasconcelos, Vitor; Urbatzka, Ralph; Reis, Mariana. "Exploiting Cyanobacterial Chemical Diversity for Anticancer Drug Discovery". Paper presented in Natural Products in Drug Discovery and Human Health (NatProdDDH) – PSE Meeting, 2019.
  15. Ferreira, Leonor; Sousa, Maria Lígia; Preto, Marco; Vasconcelos, Vitor; Urbatzka, Ralph. "Bioactivity screening of cyanobacteria for the isolation of novel anticancer compounds using 2D and 3D cell culture models". Paper presented in IMMR'18 - International Meeting on Marine Research, 2018.
    doi: 10.3389/conf.FMARS.2018.06.00089
Journal article
  1. Flávia Rodrigues; Mariana Reis; Leonor Ferreira; Clara Grosso; Ricardo Ferraz; Mónica Vieira; Vitor Vasconcelos; Rosário Martins. "The Neuroprotective Role of Cyanobacteria with Focus on the Anti-Inflammatory and Antioxidant Potential: Current Status and Perspectives". Molecules (2024): https://doi.org/10.3390/molecules29204799.
    10.3390/molecules29204799
  2. Nicole E. Avalon; Mariana A. Reis; Christopher C Thornburg; R. Thomas Williamson; Daniel Petras; Allegra T. Aron; George Neuhaus; et al. "Leptochelins A–C, Cytotoxic Metallophores Produced by Geographically Dispersed Leptothoe Strains of Marine Cyanobacteria". Journal of the American Chemical Society (2024): http://dx.doi.org/10.1021/jacs.4c05399.
    10.1021/jacs.4c05399
  3. Vitória Ramos; Mariana Reis; Leonor Ferreira; Ana Margarida Silva; Ricardo Ferraz; Mónica Vieira; Vitor Vasconcelos; Rosário Martins. "Stalling the Course of Neurodegenerative Diseases: Could Cyanobacteria Constitute a New Approach toward Therapy?". Biomolecules (2023): https://doi.org/10.3390/biom13101444.
    10.3390/biom13101444
  4. Leonor Ferreira; João Morais; Marco Preto; Raquel Silva; Ralph Urbatzka; Vitor Vasconcelos; Mariana Reis. "Uncovering the Bioactive Potential of a Cyanobacterial Natural Products Library Aided by Untargeted Metabolomics". Marine Drugs (2021): https://doi.org/10.3390/md19110633.
    10.3390/md19110633
Preprint
  1. Nicole E. Avalon; Mariana A. Reis; Christopher C. Thornburg; R. Thomas Williamson; Daniel Petras; Allegra T. Aron; George F. Neuhaus; et al. "Leptochelins A-C, Cytotoxic Metallophores Produced by Geographically Dispersed Leptothoe Strains of Marine Cyanobacteria". 2024. https://doi.org/10.26434/chemrxiv-2024-nhrn8.
    10.26434/chemrxiv-2024-nhrn8
Thesis / Dissertation
  1. Ferreira, Leonor. "Bioactivity screening of cyanobacteria for the isolation of novel anticancer compounds using 2D and 3D cell culture models". Master, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2018. https://hdl.handle.net/10216/117697.

Intellectual property

Provisional application for patent
  1. 2022. "Bioactive compounds obtained from the cyanobacteria Leptothoe sp. LEGE 181152".
    Disclosed
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/05/25 New cytotoxic macrolide-type compound isolated from a cyanobacterium Trends in Natural Products Research: A PSE’S Young Scientist Meeting
Phytochemical Society of Europe (PSE) (Crete, Greece)
2021/09/23 Combination of metabolomic tools and bioactivity screening as a strategy to find hit anticancer compounds from a library of cyanobacterial fractions Blue Think Conference
CIIMAR (Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/09 - 2022/09 Annual outreach event from CIIMAR Open Day - Porto de Leixões 2022 (2022/09 - 2022/09)
Exhibition
 Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2019/07/28 - 2019/07/31 Staff member of the organization committee: "Natural Products in Drug Discovery and Human Health" PSE meeting 2019 (2019/07/28 - 2019/07/31)
Conference (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/11/22 - 2019/11/22 Workshop - How to make a perfect scientific poster? CIIMAR PhD studens workshop
Workshop
 How to make a perfect scientific poster?
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2018/11/05 - 2018/11/07 Blue and Green course. The High Throughput Screening & Safety Course provided state-of-the-art lectures on important developments in the field of HTS: sample management, data analysis, phenotypic screening, target-based assays, whole small animal models, and secondary screenings.
Workshop
 High Throughput screening and Safety course
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2018/06/25 - 2018/06/28 Blue and Green course. This course provided state-of-the-art lectures and hands-on-training on Discovery, Isolation and Structure Elucidation of Marine Natural Products. This 4-day course will focus on important aspects of MS-based structure elucidation, NMR-based structure elucidation, Computational predictions, X-ray crystallography, Dereplication, Molecular Networks, Synthesis and Medicinal Chemistry, Metabolomics and Chemical imaging.
Workshop
 Marine Natural Products: Discovery and Structure elucidation
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2017/05/25 - 2017/05/26 Meeting on Health, Environment and Work (Encontro Saúde, Ambiente e Trabalho) – Santo António Hospital, Porto
Meeting
 II Encontro de Saúde, Ambiente e Trabalho
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Centro Hospitalar Universitário do Porto EPE, Portugal
2017/05/24 - 2017/05/24 III Analytical Chemistry Symposium: Alternative Technologies of pharmaceuticals’ removal from water
Symposium
 III Analytical Chemistry Symposium: Alternative Technologies of pharmaceuticals’ removal from water
Universidade de Aveiro, Portugal
2016/12/19 - 2016/12/20 Microplastics 2016 – 1st Portuguese Congress about Microplastics (Microplásticos 2016 – 1o Congresso Português sobre Microplásticos: Contaminação Ambiental por Microplásticos e suas Implicações para a Saúde dos Ecossistemas, Animal e Humana)
Congress
 Microplastics 2016 – 1st Portuguese Congress about Microplastics
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Distinctions

Award

2024 PSE Award for the Best Poster Presentation
Phytochemical Society of Europe, United Kingdom