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I am a biomedical engineer specializing in radiation protection and imaging, with a deep passion for the field of light and photochemistry. This led me to pursue a PhD in Photochemistry, during which I developed innovative oxygen sensors derived from natural sources and utilized them for intracellular metabolic and oxygen imaging. Currently, I am working in Germany as a Scientist, contributing to several projects related to metabolic imaging, including studies on aging, cancer, and physical rehabilitation. Looking ahead, my ambition is to establish my own research group and teach at a high-level institution, driving innovation and advancements in this dynamic field.
Identification

Personal identification

Full name
Daniela Nobre Sarmento dos Santos

Citation names

  • DC Nobre
  • Sarmento, D.
  • Sarmento-Santos, D.
  • Daniela N. S. dos Santos

Author identifiers

Ciência ID
BF1E-79A9-8914
Google Scholar ID
https://scholar.google.com/citations?user=De5LFWoAAAAJ&hl=pt-PT&oi=ao

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences
  • Medical and Health Sciences - Health Sciences - Social Biomedical Sciences
  • Medical and Health Sciences - Health Sciences - Social Biomedical Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Proficiency (C2) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Upper intermediate (B2) Upper intermediate (B2) Elementary (A2) Upper intermediate (B2) Upper intermediate (B2)
German Beginner (A1) Elementary (A2) Beginner (A1) Elementary (A2) Beginner (A1)
Education
Degree Classification
2024/06/10 - 2024/07/19
Ongoing
Top Female Founders Summer School 2024 (Postgraduate Certificate)
Major in Business
EIT Health, Germany
2018/09/01 - 2024
Ongoing
Chemistry (Doutoramento)
Major in Photochemistry
Universidade de Coimbra, Portugal
"Unveiling the Excited State Deactivation Mechanisms of Indirubin and Its Role in Metabolic and Oxygen Imaging in Living Cells" (THESIS/DISSERTATION)
2022/02 - 2022/06
Concluded
Science of Well-being (Postgraduate Certificate)
Yale University, United States
2020/06/15 - 2020/06/19
Concluded
Advanced Concepts in Pharmacogenomics (Outros)
Major in farmacogenómica
Universidade de Coimbra Faculdade de Medicina, Portugal
20
2019/05/31 - 2019/05/31
Concluded
THOR Low level light therapy Training course (Postgraduate Certificate)
Major in cold lasers
THOR LASERS, United Kingdom
Aprovada
2013/12/01 - 2014/02/15
Concluded
Certificado de Competências Pedagógicas (Outros)
Major in CCP
Psicosoma, Portugal
Aprovada
2007/09/15 - 2012/07/13
Concluded
Biomedical Engineering (Mestrado integrado)
Major in Radiation and Imaging
Universidade de Coimbra, Portugal
"Células Estaminais do Cancro do Endométrio" (THESIS/DISSERTATION)
16
2012/03/19 - 2012/03/30
Concluded
ALARA Workshop - SARA Trainning Course (Postgraduate Certificate)
Major in Protecção Radiológica
Erasmus, Netherlands
"nao aplicavel" (THESIS/DISSERTATION)
B
Affiliation

Science

Category
Host institution
Employer
2023/04/04 - 2024/12/31 Contracted Researcher (Research) Universität Ulm, Germany

Others

Category
Host institution
Employer
2018/10/15 - 2023/01/11 FCT PhD Grant Universidade de Coimbra Departamento de Química, Portugal
Universidade de Coimbra Centro de Química de Coimbra, Portugal
2016/07/15 - 2018/08/31 Research Grant Universidade de Coimbra Centro de Química de Coimbra, Portugal
Universidade de Coimbra Centro de Química de Coimbra, Portugal
2015/09/15 - 2016/07/15 Internship - Photochemistry Group Universidade de Coimbra Departamento de Química, Portugal
Universidade de Coimbra Departamento de Química, Portugal
2014/04/15 - 2015/04/14 Profissional Intership- Water Quality Control IOM unipessoal, Portugal
LifeStyle SPA, Portugal
2011/06/01 - 2011/07/31 Summer Traineeship in the Serviço de Física Médica do Instituto Português de Oncologia de Coimbra Francisco Gentil, E.P.E. Instituto Português de Oncologia de Coimbra Francisco Gentil EPE, Portugal
Instituto Português de Oncologia de Coimbra Francisco Gentil EPE, Portugal
2010/09/15 - 2010/12/15 Internship - Liposom Production Universidade de Coimbra Departamento de Ciências da Vida, Portugal
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
Outputs

Publications

Conference paper
  1. Rueck, Angelika C.; Wieland, Johannes; Reess, Kirsten; Daniela N. S. dos Santos; Naskar, Nilanjon. "Metabolic FLIM and oxygen PLIM/dFLIM in translational research". Paper presented in SPIE Photonics West, San Francisco, 2024.
    10.1117/12.3001595
  2. Daniela N. S. dos Santos; Naskar, Nilanjon; Reess, Kirsten; Delgado-Pinar, Estefanía; Seixas de Melo, João Sérgio; Rueck, Angelika. "Metabolic imaging with FLIM/PLIM indirubin derivatives: an ultrafast window into cellular metabolism and oxygen consumption". Paper presented in SPIE Photonics West, San Francisco, 2024.
    10.1117/12.3002527
Journal article
  1. Daniela N. S. dos Santos; Naskar, N.; Delgado-Pinar, E.; Reess, K.; Seixas de Melo, J.S.; Rueck, A.. "Bromine indirubin FLIM/PLIM sensors to measure oxygen in normoxic and hypoxic PDT conditions". Photodiagnosis and Photodynamic Therapy 45 (2024): 103964. http://dx.doi.org/10.1016/j.pdpdt.2024.103964.
    10.1016/j.pdpdt.2024.103964
  2. Daniela N. S. dos Santos; Delgado-Pinar, Estefanía; Cunha, Carla; Sérgio Seixas de Melo, J.. "The role of the oxime group in the excited state deactivation processes of indirubin". Physical Chemistry Chemical Physics 26 9 (2024): 7416-7423. http://dx.doi.org/10.1039/d3cp05260e.
    10.1039/d3cp05260e
  3. Daniela N. S. dos Santos; Delgado-Pinar, Estefanía; Cunha, Carla; Galvão, Adelino M.; Seixas de Melo, J. Sérgio. "Indirubin: Nature finding efficient light-activated protective molecular mechanisms". Dyes and Pigments 212 (2023): 111116. http://dx.doi.org/10.1016/j.dyepig.2023.111116.
    10.1016/j.dyepig.2023.111116
  4. Daniela N. S. dos Santos; Cunha, Carla; Porciello, Alessandro; Valentini, Federica; Marrocchi, Assunta; Vaccaro, Luigi; Galvão, Adelino M.; de Melo, J. Sérgio Seixas. "Photoresponsive N,N'-disubstituted indigo derivatives". Dyes and Pigments 176 (2020): 108197. http://dx.doi.org/10.1016/j.dyepig.2020.108197.
    10.1016/j.dyepig.2020.108197
  5. Carvalho, Maria João; Laranjo, Mafalda; Abrantes, Ana Margarida; Casalta-Lopes, João; Daniela N. S. dos Santos; Costa, Tânia; Serambeque, Beatriz; et al. "Endometrial Cancer Spheres Show Cancer Stem Cells Phenotype and Preference for Oxidative Metabolism". Pathology & Oncology Research 25 3 (2018): 1163-1174. http://dx.doi.org/10.1007/s12253-018-0535-0.
    10.1007/s12253-018-0535-0
  6. Aguiló, Elisabet; Moro, Artur J.; Outis, Mani; Pina, João; Daniela N. S. dos Santos; Seixas de Melo, J. Sérgio; Rodríguez, Laura; Lima, João Carlos. "Deactivation Routes in Gold(I) Polypyridyl Complexes: Internal Conversion Vs Fast Intersystem Crossing". Inorganic Chemistry 57 21 (2018): 13423-13430. http://dx.doi.org/10.1021/acs.inorgchem.8b01993.
    10.1021/acs.inorgchem.8b01993
  7. Pina, J.; Daniela N. S. dos Santos; Accoto, Marco; Gentili, Pier Luigi; Vaccaro, Luigi; Galvão, Adelino; Seixas de Melo, J. Sérgio. "Excited-State Proton Transfer in Indigo". The Journal of Physical Chemistry B 121 10 (2017): 2308-2318. http://dx.doi.org/10.1021/acs.jpcb.6b11020.
    10.1021/acs.jpcb.6b11020
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/09/16 Oral Communication - ''Optimizing Photodynamic Therapy through Metabolic Intracellular Pattern Segmentation'' Photodynamic Therapy and Photodiagnosis Update 2024
(Kochel am See, Germany)
2024/09/10 Oral Communication - '' Unravelling the Excited State Deactivation Mechanisms of Indirubin and Its Role in Metabolic and Oxygen Imaging in Living Cells'' VIII Jornadas Ibéricas de Fotoquímica
Sociedade Portuguesa de Química (Lisboa, Portugal)
2024/03/25 Poster - ''Mapping Intracellular pH : Insights from FLIM/PLIM Metabolic Imaging'' Focus on Microscopy 2024
University of Genoa (Genoa, Italy)
2024/01/30 Oral Communication - Metabolic imaging with FLIM/PLIM indirubin derivatives: an ultrafast window into cellular metabolism and oxygen consumption SPIE Photonics West
SPIE (San Francisco, United States)
2024/01/22 Poster - ''Tracking Intracellular pH through FLIM/PLIM Metabolic Imaging Algorithms'' 21st Workshop Advanced Imaging Methods
Univeristy of California, Berkeley (Berkeley, United States)
2023/07/10 Poster - ''Bromine indirubin FLIM/PLIM sensors to measure oxygen in normoxic and hypoxic PDT conditions'' 18th International Photodynamic Association World Congress
IPA (Tampere, Finland)
2021/03/29 Oral Communication - Photophysics and Photochemistry in N,N'-disubstituted indigo derivatives: Competition between ESPT and photoisomerization 14º Encontro Nacional de Química Física
universidade de coimbra, sociedade portuguesa de química (coimbra, Portugal)
2020/02/13 Three Minute Thesis competition (3MT) Three Minute Thesis competition
universidade de coimbra (coimbra, Portugal)
2019/09/02 Poster - "Excited State Deactivation Mechanisms in Indirubin: Photostability and Interaction (with Guanine Rich sequences." Light and Life Barcelona , Spain (17th Congress of the International Union of Photobiology and 18th Congress of the European Society for Photobiology)
(Barcelona, Spain)
2018/09/12 Poster - "ON THE HIGH PHOTOSTABILITY OF INDIRUBIN" 6ª jornadas ibericas de fotoquímica
universidade de aveiro (aveiro, Portugal)
2017/07/17 Poster - ''The photostability and interaction with Biomolecular Targets of Indirubin'' Encontro nacional SPQ Lisbon
sociedade portuguesa de química (Lisboa, Portugal)
2012/07/06 Poster - ‘’Doxorubicin cytotocicity in Endometrial Cancer: Importance of Stem Cells’’ EACR-22 Barcelona
EACR Barcelona (Barcelona, Spain)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2024/02/26 - 2024/02/29 FLIM/PLIM Workshop- Hands On provider together with Becker and Hickl and Dr. Angelika Rueck
Workshop
GerBi FLIM Workshop
German BioImaging, Germany

Association member

Society Organization name Role
2020/05/08 - Current Cartas com Ciência (letters with science) Trocar cartas e levar a ciência a todos os cantos da lusofonia - Exchanging letters in Portuguese with children and/or young people from Portuguese-speaking countries.

Conference scientific committee

Conference name Conference host
2024/09/16 - 2024/09/20 Photodynamic Therapy and Photodiagnosis Update 2024 Kochel am See
2024/01/22 - 2024/01/25 21st Workshop Advanced Imaging Methods Berkeley, CA, EUA

Interview (tv / radio show)

Program Topic
2021/03/04 - 2021/03/04 PodCast Molecular Divulgação de Ciência - Fotoquímica e Fotobiologia
Distinctions

Award

2024 SPIE Student Award
2008 The 3% Best Students Award in the year 2008/2009
Universidade de Coimbra, Portugal