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Sílvia Andreia Sousa. Concluiu o(a) Doutoramento em Biotecnologia em 2007/03/31 pelo(a) Universidade de Lisboa Instituto Superior Técnico e Licenciatura em Biologia Microbiana e Genética em 2001/07 pelo(a) Universidade de Lisboa Faculdade de Ciências. É Investigador Contratado no(a) Associação para o Desenvolvimento do Instituto Superior Técnico e Professor Auxiliar Convidado no(a) Universidade de Lisboa Instituto Superior Técnico. Publicou 48 artigos em revistas especializadas. Possui 6 capítulo(s) de livros. Recebeu 4 prémio(s) e/ou homenagens. Participa e/ou participou como Bolseiro de Cientista Convidado em 1 projeto(s), Bolseiro de Doutoramento em 1 projeto(s), Bolseiro de Pós-Doutoramento em 2 projeto(s), Investigador em 9 projeto(s) e Investigador responsável em 1 projeto(s). Atua na(s) área(s) de Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Microbiologia. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Burkholderia cepacia complex; Cystic fibrosis; Immunogenic proteins; new antimicrobials; Therapeutic antibodies; Pseudomonas aeruginosa; Multidrug resistance; .
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Identification

Personal identification

Full name
Sílvia Andreia Sousa

Citation names

  • Sousa, Sílvia A.

Author identifiers

Ciência ID
C013-C2E6-EE4C
ORCID iD
0000-0001-9291-9169

Email addresses

  • sousasilvia@tecnico.ulisboa.pt (Professional)

Telephones

Telephone
  • 218419986 (Professional)

Addresses

  • Instituto Superior Técnico, Av. Rovisco Pais, Torre Sul, 6º Piso, 1049-001, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2) Advanced (C1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Elementary (A2) Beginner (A1)
Education
Degree Classification
2015/08/01 - 2018/11/14
Concluded
 SFRH/BPD/102006/2014 (Pós-doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017
Concluded
 XII Course on Laboratory Animal Science (Outros)
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Universiteit Utrecht, Netherlands
Aprovado
2007/04/01 - 2013/03/31
Concluded
 SFRH/BPD/27079/ 2006 (Pós-doutoramento)
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2002/10/01 - 2007/03/31
Concluded
 Biotecnologia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Burkholderia cepacia complex infections in cystic fibrosis patients: biosynthesis and role of the exopolysaccharide and investigation of other potential virulence factors" (THESIS/DISSERTATION)
 Aprovado por unanimidade
2003/04/01 - 2004/03/31
Concluded
 PhD Trainee (Outros)
Eberhard Karls Universität Tübingen Institut für Medizinische Mikrobiologie und Hygiene, Germany
2003/09/01 - 2003/09/30
Concluded
 PhD Trainee (Outros)
Cardiff University School of Medicine, United Kingdom
1996/09 - 2001/07
Concluded
 Biologia Microbiana e Genética (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Papel do exopolissacárido nas infecções respiratórias por Burkholderia cepacia em doentes com Fibrose Quística." (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2018/11/15 - Current Contracted Researcher (Research) Associação para o Desenvolvimento do Instituto Superior Técnico, Portugal
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2007/04/01 - 2018/11/14 Postdoc (Research) Associação para o Desenvolvimento do Instituto Superior Técnico, Portugal
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2011/12/01 - 2011/12/31 Visiting Researcher (Research) Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2011/07/01 - 2011/07/31 Visiting Researcher (Research) Eberhard Karls Universität Tübingen Institut für Medizinische Mikrobiologie und Hygiene, Germany

Teaching in Higher Education

Category
Host institution 		Employer
2019/09/01 - Current Invited Assistant Professor (University Teacher) Universidade de Lisboa Instituto Superior Técnico, Portugal
Projects

Grant

Designation Funders
2015/08 - 2018/11 SFRH/BPD/102006/2014
SFRH/BPD/102006/2014
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2013/06 - 2015/07 PTDC/BBB-BIO/1958/2012
PTDC/BBB-BIO/1958/2012
Invited Scientist Fellow
Concluded
2007/04 - 2013/03 SFRH/BPD/27079/ 2006
SFRH/BPD/27079/ 2006
Post-doc Fellow
Concluded
2002/10 - 2006/09 SFRH/BD/8906/2002
SFRH/BD/8906/2002
PhD Student Fellow
Concluded

Contract

Designation Funders
2023/01/01 - Current Os RNAs não codificantes contidos em vesiculas extracelulares produzidas pelo complexo Burkholderia cepacia manipulam a resposta imunitária do hospedeiro?
2022.07091.PTDC
Researcher
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/05 - 2019/10 CNCVir - The coding and noncoding virulome of Burkholderia cenocepacia
Provided by PTCRIS: 140240
PTDC/BIA-MIC/1615/2014
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2016/07 - 2017/12 Extracellular production of heterologous antigenic proteins in Escherichia coli platform – an integrated approach.
Funded by UID/BIO/04565/2013
Researcher
Concluded
2016/07 - 2017/12 Aerobic granular sludge technology toward effective elimination of the azo dye in textile wastewater treatment
Funded by UID/BIO/04565/2013
Researcher
Concluded
2012/01 - 2016/06 RNomics-Bcc: RNomics studies to identify small non-coding RNAs of Burkholderia cepacia complex involved in host-pathogen interactions
Provided by PTCRIS: 119091
PTDC/BIA-MIC/119091/2010
119091
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2013/04/01 - 2015/09/30 Exploitation of immunogenic proteins of the Burkholderia cepacia complex to design new diagnostic and therapeutic strategies.
Provided by PTCRIS: 127429
PTDC/BBB-BIO/1958/2012
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2010/01 - 2013/05 Exploiting the type II phosphomannose isomerase BceAJ as a new target for the development of new antimicrobials and for biotechnological applications
Provided by PTCRIS: 98352
PTDC/EBB-BIO/098352/2008
98352
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2010/01 - 2011/12 Regulation of Burkholderia cenocepacia gene expression under low oxygen tensions.
A-09/10, bilateral cooperation Portugal-Germany CRUP/DAAD
Researcher
Concluded
2008/01 - 2011/06 Optimization and Control of Intermittent UASB Reactors and Microbial Population Dynamics
Provided by PTCRIS: 65025
PDTC/AMB/65025/2006
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2003/01 - 2006/06 Studies to produce an exopolysaccharide - vaccine to protect cystic fibrosis patients against Burkholderia cepacia infections.
POCTI/BIO/38273/2001
Researcher
Concluded
Outputs

Publications

Book chapter
  1. Vera L. R. Esgueira; Clara P. A. Lopes; Ana Catarina A. dos Santos; Fátima Pinto; Silvia A. Sousa; Dragana P. C. de Barros; Jorge H. Leitão; Luis P. Fonseca. "LipNanoCar Technology – A Versatile and Scalable Technology for the Production of Lipid Nanoparticles". 43-82. Springer International Publishing, 2022.
    10.1007/978-3-030-88071-2_3
  2. Leitão, Jorge H.; Feliciano, Joana R.; Sousa, Sílvia A.; Pita, Tiago; Guerreiro, Soraia I.. "Burkholderia cepacia Complex Infections Among Cystic Fibrosis Patients: Perspectives and Challenges". In Progress in Understanding Cystic Fibrosis. InTech, 2017.
    Published • 10.5772/67712
  3. Leitão, J.H.; Ramos, C.G.; Feliciano, J.R.; Sousa, S.A.; Grilo, A.M.; da Costa, P.J.P.. "Hfq-like RNA chaperones and small non-coding regulatory RNAs: A new paradigm of bacterial gene regulation". 2014.
  4. Leitão JH; Sousa, Sílvia A.; Ramos CG; Feliciano JR; Grilo AM; da Costa PJP. "Experimental and bioinformatics approaches to identify potential targets and develop novel strategies to fight infections caused by multiresistant Burkholderia cepacia complex bacteria". In Microbial pathogens and strategies for combating them: science, technology and education, 372-383. Microbiology Book series, Formatex Research Center, 2013.
    Published
  5. A., Silvia; R., Joana; H., Jorge. "Activated Sugar Precursors: Biosynthetic Pathways and Biological Roles of an Important Class of Intermediate Metabolites in Bacteria". In Biotechnology of Biopolymers, 257-274. InTech, 2011.
    Published • 10.5772/19649
  6. Sousa, Sílvia A.; Ramos CG; Feliciano JR; Leitão JH. "Bacterial type II PMIs: Exploitable bifunctional enzymes for biotechnological applications and the rational design of antimicrobials". In Biopolymers, 285-302. InTech, 2010.
    Published
Conference paper
  1. S.A. Sousa; T. Pita; J.R. Feliciano; P. Soares-Castro; M. Morad; C. Barreto; L. Pereira; et al. "117 Exploitation of immunogenic proteins of the Burkholderia cepacia complex to design new therapeutic strategies". 2013.
    10.1016/s1569-1993(17)30481-2
  2. S.A. Sousa; J.R. Feliciano; C.G. Ramos; J.H. Leitão. "111 The Burkholderia cenocepacia J2315 small non-coding RNA MavA is required for fitness and virulence". 2013.
    10.1016/s1569-1993(13)60253-2
  3. S.A. Sousa; P. Soares-Castro; J.R. Feliciano; C.G. Ramos; P.M. Santos; J.H. Leitão. "113 Unveiling the Burkholderia cenocepacia J2315 RNA chaperone Hfq2 interactome". 2013.
    10.1016/s1569-1993(13)60255-6
  4. A. Pinto-de-Oliveira; C.P. Coutinho; C.G. Ramos; S.A. Sousa; C.C.C.R. de Carvalho; J.H. Leitão; I. Sá-Correia. "109 The Burkholderia cepacia small colony variants (SCV) are a more pathogenic bacterial form that may facilitate persistent respiratory infections in CF patients". 2013.
    10.1016/s1569-1993(13)60251-9
  5. Sousa SA. "Microbial population shifts as a tool for improving biogas production in anaerobic reactors". 2011.
Journal article
  1. António M. M. Seixas; Sara C. Gomes; Carolina Silva; Leonilde M. Moreira; Jorge H. Leitão; Sílvia A. Sousa. "A Polyclonal Antibody against a Burkholderia cenocepacia OmpA-like Protein Strongly Impairs Pseudomonas aeruginosa and B. multivorans Virulence". Vaccines (2024): https://doi.org/10.3390/vaccines12020207.
    10.3390/vaccines12020207
  2. Rui N. L. Carvalho; Luisa L. Monteiro; Silvia A. Sousa; Sudarsu V. Ramanaiah; Jorge H. Leitão; Cristina M. Cordas; Luis P. Fonseca. "Design and Optimization of Microbial Fuel Cells and Evaluation of a New Air-Breathing Cathode Based on Carbon Felt Modified with a Hydrogel—Ion Jelly®". Energies (2023): https://doi.org/10.3390/en16104238.
    10.3390/en16104238
  3. Andreia Sousa; Joana F. Santos; Francisco Silva; Sílvia A. Sousa; Jorge H. Leitão; António P. Matos; Teresa Pinheiro; et al. "Antitumoral and Antimicrobial Activities of Block Copolymer Micelles Containing Gold Bisdithiolate Complexes". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15020564.
    10.3390/pharmaceutics15020564
  4. António M. M. Seixas; Sílvia A. Sousa; Jorge H. Leitão. "Antibody-Based Immunotherapies as a Tool for Tackling Multidrug-Resistant Bacterial Infections". Vaccines (2022): https://doi.org/10.3390/vaccines10111789.
    10.3390/vaccines10111789
  5. Sousa SA. "Bixa orellana L. from northern Brazil: morphological analysis, phenolic content, antioxidant and antibacterial activities". Brazilian Journal of Botany 45 3 (2022): 883-896. http://dx.doi.org/10.1007/s40415-022-00832-1.
    10.1007/s40415-022-00832-1
  6. Yann Le Gal; Agathe Filatre-Furcate; Dominique Lorcy; Olivier Jeannin; Thierry ROISNEL; Vincent Dorcet; Diana Fontinha; et al. "Broad Spectrum Functional Activity of Structurally Related Monoanionic Au(III) Bis(Dithiolene) Complexes". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/13/7146.
    10.3390/ijms23137146
  7. António M. M. Seixas; Sílvia A. Sousa; Joana R. Feliciano; Sara C. Gomes; Mirela R. Ferreira; Leonilde M. Moreira; Jorge H. Leitão. "A Polyclonal Antibody Raised against the Burkholderia cenocepacia OmpA-like Protein BCAL2645 Impairs the Bacterium Adhesion and Invasion of Human Epithelial Cells In Vitro". Biomedicines (2021): https://doi.org/10.3390/biomedicines9121788.
    10.3390/biomedicines9121788
  8. Joana P. Costa; Sílvia A. Sousa; Catarina Soeiro; Jorge H. Leitão; Adelino M. Galvão; Fernanda Marques; M. Fernanda N. N. Carvalho. "Synthesis and Characterization of Camphorimine Au(I) Complexes with a Remarkably High Antibacterial Activity towards B. contaminans and P. aeruginosa". Antibiotics 10 10 (2021): 1272-1272. https://doi.org/10.3390/antibiotics10101272.
    10.3390/antibiotics10101272
  9. Sílvia A. Sousa; Joana R. Feliciano; Tiago Pita; Catarina F. Soeiro; Beatriz L. Mendes; Luis G. Alves; Jorge H. Leitão. "Bacterial Nosocomial Infections: Multidrug Resistance as a Trigger for the Development of Novel Antimicrobials". Antibiotics (2021): https://doi.org/10.3390/antibiotics10080942.
    10.3390/antibiotics10080942
  10. "Sono-Biosynthesis and Characterization of AuNPs from Danube Delta Nymphaea alba Root Extracts and Their Biological Properties". Nanomaterials 11 6 (2021): 1562-1562. http://dx.doi.org/10.3390/nano11061562.
    10.3390/nano11061562
  11. Sousa SA; António Seixas; Joana Monteiro Marques; Jorge H. Leitão. "Immunization and Immunotherapy Approaches against Pseudomonas aeruginosa and Burkholderia cepacia Complex Infections". Vaccines (2021): https://www.mdpi.com/2076-393X/9/6/670.
    10.3390/vaccines9060670
  12. Costa, Joana; Sousa, Sílvia; Galvão, Adelino; Mata, J.; Leitão, Jorge; Carvalho, M.. "Key Parameters on the Antibacterial Activity of Silver Camphor Complexes". Antibiotics 10 2 (2021): 135. http://dx.doi.org/10.3390/antibiotics10020135.
    Open access • Published • 10.3390/antibiotics10020135
  13. Sousa SA; António Seixas; Manoj Mandal; Manuel J. Rodríguez-Ortega; Jorge H. Leitão. "Characterization of the Burkholderia cenocepacia J2315 Surface-Exposed Immunoproteome". Vaccines (2020): https://www.mdpi.com/2076-393X/8/3/509.
    10.3390/vaccines8030509
  14. Nady, Soad; Abdel-Rahman, Mona; Sousa, Silvia; Leitão, Jorge; Morad, Mostafa; El-Hennamy, Rehab. "Differential effects of Th17 cytokines during the response of neutrophils to Burkholderia cenocepacia outer membrane protein A". Central European Journal of Immunology 44 4 (2020): 403-413. http://dx.doi.org/10.5114/ceji.2019.92800.
    Open access • Published • 10.5114/ceji.2019.92800
  15. Sousa, Sílvia A.; Soares-Castro, Pedro; Seixas, António M.M.; Feliciano, Joana R.; Balugas, Bernardo; Barreto, Celeste; Pereira, Luísa; Santos, Pedro M.; Leitão, Jorge H.. "New insights into the immunoproteome of B. cenocepacia J2315 using serum samples from cystic fibrosis patients". New Biotechnology 54 (2020): 62-70. http://dx.doi.org/10.1016/j.nbt.2019.08.006.
    Published • 10.1016/j.nbt.2019.08.006
  16. Sousa, Sílvia A.; Leitão, Jorge H.; Silva, Rafaela A.L.; Belo, Dulce; Santos, Isabel C.; Guerreiro, Joana F.; Martins, Marta; et al. "On the path to gold: Monoanionic Au bisdithiolate complexes with antimicrobial and antitumor activities". Journal of Inorganic Biochemistry 202 (2020): 110904. http://dx.doi.org/10.1016/j.jinorgbio.2019.110904.
    Open access • Published • 10.1016/j.jinorgbio.2019.110904
  17. Fontinha, Diana; Sousa, Silvia Andreia; Morais, Tânia S.; Prudêncio, Miguel; Leitão, Jorge; Le Gal, Yann; Lorcy, Dominique; et al. "Gold(III) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents". Metallomics (2020): http://dx.doi.org/10.1039/d0mt00064g.
    Accepted • 10.1039/d0mt00064g
  18. Mihaela Cudalbeanu; Bianca Furdui; Geta Cârâc; Vasilica Barbu; Alina Viorica Iancu; Fernanda Marques; Jorge Humberto Leitão; Sílvia Andreia Sousa; Rodica Mihaela Dinica. "Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts". Antibiotics 9 1 (2019): 7-7. https://doi.org/10.3390/antibiotics9010007.
    10.3390/antibiotics9010007
  19. Luis G. Alves; João F. Portel; Sílvia A. Sousa; Olga Ferreira; Stephanie Almada; Elisabete R. Silva; Ana M. Martins; Jorge H. Leitão. "Investigations into the Structure/Antibacterial Activity Relationships of Cyclam and Cyclen Derivatives". Antibiotics 8 4 (2019): 224-224. https://doi.org/10.3390/antibiotics8040224.
    10.3390/antibiotics8040224
  20. Joana P. Costa; M. Joana F. Pinheiro; Sílvia A. Sousa; Ana M. Botelho do Rego; Fernanda Marques; M. Conceição Oliveira; Jorge H. Leitão; Nuno P. Mira; M. Fernanda N. N. Carvalho. "Antimicrobial Activity of Silver Camphorimine Complexes against Candida Strains". Antibiotics (2019): https://doi.org/10.3390/antibiotics8030144.
    10.3390/antibiotics8030144
  21. Sousa, Sílvia. "Silver Camphor Imine Complexes: Novel Antibacterial Compounds from Old Medicines". Antibiotics (2018): http://www.mdpi.com/2079-6382/7/3/65.
    10.3390/antibiotics7030065
  22. Sousa, Sílvia. "Postgenomic Approaches and Bioinformatics Tools to Advance the Development of Vaccines against Bacteria of the Burkholderia cepacia Complex". Vaccines (2018): http://www.mdpi.com/2076-393X/6/2/34.
    10.3390/vaccines6020034
  23. Sousa, Sílvia. "Burkholderia puraquae sp. nov., a novel species of the Burkholderia cepacia complex isolated from hospital settings and agricultural soils.". International journal of systematic and evolutionary microbiology (2017): http://europepmc.org/abstract/med/29095137.
    10.1099/ijsem.0.002293
  24. Ana S. Moreira; Dalila Mil-Homens; Sílvia A. Sousa; Carla P. Coutinho; Ana Pinto-de-Oliveira; Christian G. Ramos; Sandra C. dos Santos; et al. "Variation of Burkholderia cenocepacia virulence potential during cystic fibrosis chronic lung infection". Virulence (2017): 1-15. https://doi.org/10.1080/21505594.2016.1237334.
    10.1080/21505594.2016.1237334
  25. Sousa SA; Feliciano JR; Pita T; Guerreiro SI; Leitão JH. "Burkholderia cepacia Complex Regulation of Virulence Gene Expression: A Review.". (2017): http://europepmc.org/abstract/med/28106859.
    10.3390/genes8010043
  26. Sousa SA; Morad M; Feliciano JR; Pita T; Nady S; El-Hennamy RE; Abdel-Rahman M; et al. "The Burkholderia cenocepacia OmpA-like protein BCAL2958: identification, characterization, and detection of anti-BCAL2958 antibodies in serum from B. cepacia complex-infected Cystic Fibrosis patients.". (2016): http://europepmc.org/abstract/med/27325348.
    10.1186/s13568-016-0212-1
  27. Feliciano JR; Grilo AM; Guerreiro SI; Sousa SA; Leitão JH. "Hfq: a multifaceted RNA chaperone involved in virulence.". (2016): http://europepmc.org/abstract/med/26685037.
    10.2217/fmb.15.128
  28. Sílvia A. Sousa; Jorge H. Leitão; Raul C. Martins; João M. Sanches; Jasjit S. Suri; Alejandro Giorgetti. "Bioinformatics Applications in Life Sciences and Technologies". BioMed Research International 2016 (2016): 1-2. http://dx.doi.org/10.1155/2016/3603827.
    10.1155/2016/3603827
  29. Ramos CG; Grilo AM; Sousa SA; Feliciano JR; da Costa PJ; Leitão JH. "Regulation of Hfq mRNA and protein levels in Escherichia coli and Pseudomonas aeruginosa by the Burkholderia cenocepacia MtvR sRNA.". (2014): http://europepmc.org/abstract/med/24901988.
    https://doi.org/10.1371/journal.pone.0098813
  30. Sousa, S.A.; Feliciano, J.R.; Grilo, A.M.; Leitão, J.H.. "Bioinformatics: A molecular microbiologist's perspective". Current Bioinformatics 9 1 (2014): 8-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893420498&partnerID=MN8TOARS.
    10.2174/1574893608999140109121908
  31. Sousa, S.A.; Feliciano, J.R.; Pinheiro, P.F.; Leitão, J.H.. "Biochemical and Functional Studies on the Burkholderia cepacia Complex bceN Gene, Encoding a GDP-D-Mannose 4,6-Dehydratase". PLoS ONE 8 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874519520&partnerID=MN8TOARS.
    10.1371/journal.pone.0056902
  32. Ramos, C.G.; Sousa, S.A.; Grilo, A.M.; Da Costa, P.J.P.; Feliciano, J.R.; Leitão, J.H.. "A RNomics-based strategy identifies regulatory small RNAs in Burkholderia cepacia complex". 1st Portuguese Meeting in Biomedical Engineering, ENBENG 2011 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80053972949&partnerID=MN8TOARS.
    10.1109/ENBENG.2011.6026035
  33. Sousa, S.A.; Ramos, C.G.; Feliciano, J.; Leitão, J.H.. "Identification and exploitation of Burkholderia cepacia complex virulence factors as potential antimicrobial targets". 1st Portuguese Meeting in Biomedical Engineering, ENBENG 2011 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80053961594&partnerID=MN8TOARS.
    10.1109/ENBENG.2011.6026036
  34. Nadais, H.; Barbosa, M.; Capela, I.; Arroja, L.; Ramos, C.G.; Grilo, A.; Sousa, S.A.; Leitão, J.H.. "Enhancing wastewater degradation and biogas production by intermittent operation of UASB reactors". Energy 36 4 (2011): 2164-2168. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952818378&partnerID=MN8TOARS.
    10.1016/j.energy.2010.03.007
  35. Sousa, S.A.; Ramos, C.G.; Leitão, J.H.. "Burkholderia cepacia complex: Emerging multihost pathogens equipped with a wide range of virulence factors and determinants". International Journal of Microbiology (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79951969857&partnerID=MN8TOARS.
    10.1155/2011/607575
  36. Leitão JH; Sousa SA; Ferreira AS; Ramos CG; Silva IN; Moreira LM. "Pathogenicity, virulence factors, and strategies to fight against Burkholderia cepacia complex pathogens and related species.". (2010): http://europepmc.org/abstract/med/20390415.
    https://doi.org/10.1007/s00253-010-2528-0
  37. Ramos CG; Sousa SA; Grilo AM; Eberl L; Leitão JH. "The Burkholderia cenocepacia K56-2 pleiotropic regulator Pbr, is required for stress resistance and virulence.". (2010): http://europepmc.org/abstract/med/20206249.
    https://doi.org/10.1016/j.micpath.2010.02.006
  38. Sousa SA; Ramos CG; Moreira LM; Leitão JH. "The hfq gene is required for stress resistance and full virulence of Burkholderia cepacia to the nematode Caenorhabditis elegans.". (2010): http://europepmc.org/abstract/med/19942656.
    https://doi.org/10.1099/mic.0.035139-0
  39. Ferreira AS; Leitão JH; Silva IN; Pinheiro PF; Sousa SA; Ramos CG; Moreira LM. "Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.". (2010): http://europepmc.org/abstract/med/19948863.
    https://doi.org/10.1128/aem.01828-09
  40. Ramos CG; Grilo AM; Sousa SA; Barbosa ML; Nadais H; Leitão JH. "A new methodology combining PCR, cloning, and sequencing of clones discriminated by RFLP for the study of microbial populations: application to an UASB reactor sample.". (2010): http://europepmc.org/abstract/med/19844706.
    https://doi.org/10.1007/s00253-009-2268-1
  41. Sousa SA; Ramos CG; Almeida F; Meirinhos-Soares L; Wopperer J; Schwager S; Eberl L; Leitão JH. "Burkholderia cenocepacia J2315 acyl carrier protein: a potential target for antimicrobials' development?". (2008): http://europepmc.org/abstract/med/18771721.
    https://doi.org/10.1016/j.micpath.2008.08.002
  42. Leitão, J.H.; Sousa, S.A.; Cunha, M.V.; Salgado, M.J.; Melo-Cristino, J.; Barreto, M.C.; Sá-Correia, I.. "Variation of the antimicrobial susceptibility profiles of Burkholderia cepacia complex clonal isolates obtained from chronically infected cystic fibrosis patients: A five-year survey in the major Portuguese treatment center". European Journal of Clinical Microbiology and Infectious Diseases 27 11 (2008): 1101-1111. http://www.scopus.com/inward/record.url?eid=2-s2.0-55549117784&partnerID=MN8TOARS.
    10.1007/s10096-008-0552-0
  43. Sousa, S.A.; Moreira, L.M.; Leitão, J.H.. "Functional analysis of the Burkholderia cenocepacia J2315 BceAJ protein with phosphomannose isomerase and GDP-d-mannose pyrophosphorylase activities". Applied Microbiology and Biotechnology 80 6 (2008): 1015-1022. http://www.scopus.com/inward/record.url?eid=2-s2.0-53249134462&partnerID=MN8TOARS.
    10.1007/s00253-008-1612-1
  44. Sousa, S.A.; Ulrich, M.; Bragonzi, A.; Burke, M.; Worlitzsch, D.; Leitão, J.H.; Meisner, C.; et al. "Virulence of Burkholderia cepacia complex strains in gp91phox-/-mice". Cellular Microbiology 9 12 (2007): 2817-2825. http://www.scopus.com/inward/record.url?eid=2-s2.0-35948975135&partnerID=MN8TOARS.
    10.1111/j.1462-5822.2007.00998.x
  45. Sousa, S.A.; Moreira, L.M.; Wopperer, J.; Eberl, L.; Sá-Correia, I.; Leitão, J.H.. "The Burkholderia cepacia bceA gene encodes a protein with phosphomannose isomerase and GDP-d-mannose pyrophosphorylase activities". Biochemical and Biophysical Research Communications 353 1 (2007): 200-206. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845659599&partnerID=MN8TOARS.
    10.1016/j.bbrc.2006.12.016
  46. Ferreira, A.S.; Leitão, J.H.; Sousa, S.A.; Cosme, A.M.; Sá-Correia, I.; Moreira, L.M.. "Functional analysis of Burkholderia cepacia genes bceD and bceF, encoding a phospholyrosine phosphatase and a tyrosine autokinase, respectively: Role in exopolysaccharide biosynthesis and biofilm formation". Applied and Environmental Microbiology 73 2 (2007): 524-534. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846443658&partnerID=MN8TOARS.
    10.1128/AEM.01450-06
  47. Cunha, M.V.; Sousa, S.A.; Leitão, J.H.; Moreira, L.M.; Videira, P.A.; Sá-Correia, I.. "Studies on the involvement of the exopolysaccharide produced by cystic fibrosis-associated isolates of the Burkholderia cepacia complex in biofilm formation and in persistence of respiratory infections". Journal of Clinical Microbiology 42 7 (2004): 3052-3058. http://www.scopus.com/inward/record.url?eid=2-s2.0-3142721877&partnerID=MN8TOARS.
    10.1128/JCM.42.7.3052-3058.2004
  48. Moreira, L.M.; Videira, P.A.; Sousa, S.A.; Leitão, J.H.; Cunha, M.V.; Sá-Correia, I.. "Identification and physical organization of the gene cluster involved in the biosynthesis of Burkholderia cepacia complex exopolysaccharide". Biochemical and Biophysical Research Communications 312 2 (2003): 323-333. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344845053&partnerID=MN8TOARS.
    10.1016/j.bbrc.2003.10.118

Other

Other output
  1. Insights into the antibacterial activity of cyclam derivatives. 2021. Luis Alves; Beatriz Mendes; Silvia Sousa; Stephanie Almada; Elisabete Silva; Jorge Leitão. https://doi.org/10.3390%2Fecmc2021-11386.
    10.3390/ecmc2021-11386
  2. Antibacterial activity of cyclam derivatives. 2018. Luis Alves; João Portel; Sílvia Sousa; Jorge Leitão; Ana Martins. https://doi.org/10.3390%2Fecmc-4-05595.
    10.3390/ecmc-4-05595
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019 - 2019 Contribution to the identification of surface-exposed immunogenic proteins of bactéria from the Burkholderia cepacia complex
Co-supervisor
 Microbiologia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
Distinctions

Other distinction

2015 Best Poster award, Topic "Cellular Microbiology and Pathogenesis", Poster "“Dissecting the biological roles played by each of the two distinct HFQ-like proteins”".
2011 Honorable Mention “Prémios Jovens Investigadores UTL/Deloitte 2011”. Scientific area: Engenharia Biológica e Biotecnologia.
2010 Honorable Mention “Prémios Jovens Investigadores UTL/Deloitte 2010”. Scientific area: Engenharia Biológica e Biotecnologia.
2007 Honorable mention- Poster "The outer membrane protein A (OmpA) and the acyl carrier protein (ACP) are virulence determinants of Burkholderia cenocepacia J2315" presented at Microbiotec 2007. Topic: Clinical Microbiology, Genetics and Health Biotechnology.