???global.info.a_carregar???
Maria Lurdes Barrela Patricio Gano. Lurdes Gano graduated in Pharmacy by Faculdade de Farmácia, Universidade de Lisboa(FFUL) in 1984 and has got a PhD in Pharmacy (Pharmaceutical Chemistry) in 2000, also at FFUL, under the supervision of Dr. L. Patrício and Prof S. Mather with specialization in the field of Radiolabelled Monoclonal Antibodies and Receptor Specific Peptides. In 1985, Lurdes Gano was engaged as a research trainee at the research institute Laboratório Nacional de Engenharia e Tecnologia Industrial (LNETI). Since then, her academic and scientific career was developed in the field of Radiopharmaceutical Sciences as: Research assistant from 1990 ¿ 2000 at LNETI/ INETI; Auxiliary investigator 2000 ¿ 2021 at Instituto Tecnológico e Nuclear (ITN). Currently, is Principal Investigator at C2TN and DECN from IST. Her domain of research has been focused in the development of biospecific radiopharmaceuticals for molecular imaging and systemic targeted therapy in Nuclear Medicine. Research activities have been mostly centered on the radiolabelling of antibodies, peptides and small molecules with different radionuclides and subsequent radiochemical, in vitro and in vivo stability and biological evaluation as specific radioactive probes for theranostics. In the past few years, she has been involved in the synthesis, characterization and biological evaluation of In/111In-based compounds aiming their application for targeted radiotherapy of estrogen receptor expressing tumors. To achieve that goal two different classes of biomolecules have been explored estradiol-based and peptides based on the LXXLL motif. As part of a long-time experience on radiochemical and biological assessment of radiopharmaceuticals, her main scientific activities are related with the preclinical evaluation of radioactive compounds and nanoplatforms (micelles, lipossomes and gold nanoparticles) to assess their potential interest for molecular imaging, systemic targeted therapy or targeted drug delivery. Such studies are mostly based on cell culture assays and imaging, biodistribution and biokinetics studies in small animal models, namely: receptor binding affinity studies; citotoxicity and cellular uptake/internalization and efflux studies of radioactive compounds; ex-vivo biodistribution, in vivo stability, metabolization and pharmacokinetics studies of radiometal complexes and radioiodinated compounds in experimental small animal models (healthy and disease models as infection or tumour-bearing animals). Author of 117 papers in international peer review journals (more than 65% in Q1 journals) with a total of 1800 citations and 37 papers published as proceedings of refereed conferences in the scientific domain of Chemical and Radiopharmaceutical Sciences. Within the framework of the divulgation of results has more than 175 communication, 55 of them as oral, in international meetings. The h-index is 27.
Identification

Personal identification

Full name
Maria Lurdes Barrela Patricio Gano

Citation names

  • Gano, Lurdes
  • Gano, Maria Lurdes
  • Patricio G., Lurdes

Author identifiers

Ciência ID
C11F-51E3-6084
ORCID iD
0000-0001-7186-2060
Researcher Id
J-6929-2013
Scopus Author Id
8976995900

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2000/07/28
Concluded
Pharmacy (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Radiolabelled Antibodies and Peptides with Tecnécio-99m" (THESIS/DISSERTATION)
PhD with honours
1990/10
Concluded
Radiopharmaceutical Sciences (Mestrado integrado)
Laboratório Nacional de Engenharia e Tecnologia Nuclear, Portugal
Very Good
1984/06
Concluded
Pharmaceutical Sciences (Licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Relatório de actividades em Análises Clínicas" (THESIS/DISSERTATION)
15/20
Affiliation

Science

Category
Host institution
Employer
2021/02/01 - Current Principal Investigator (Research) Centro de Ciências e Tecnologias Nucleares, Portugal
2012 - 2021/02/01 Auxiliary Researcher (Research) Centro de Ciências e Tecnologias Nucleares, Portugal
2000 - 2012 Auxiliary Researcher (Research) Instituto Tecnológico e Nuclear, Portugal
1997 - 2000 Research Assistant (Research) Instituto Tecnológico e Nuclear, Portugal
1990 - 1997 Research Assistant (Research) Instituto Nacional de Engenharia e Tecnologia Nuclear, Portugal
1985/06 - 1990/10 Research Trainee (Research) Laboratório Nacional de Engenharia e Tecnologia Nuclear, Portugal
Projects

Grant

Designation Funders
2021 - 2024 Rifabutin liposomes: a novel nanotechnological strategy for effective treatment of systemic methicilin-resistant staphylococus aureus infections
Phospholipid Research Center
Researcher
Ongoing
2018 - 2020 DRug dElivery nAnosysteM for HPV infection therapy
UTAP-EXPL/NTec/0015/2017
Researcher
Concluded
2000 - 2006 Lanthanides in Therapy: Particle Emitting Radiolanthanides and Stable Lanthanides with Radiation Induced by External Irradiation
COST D18
Researcher
Concluded

Contract

Designation Funders
2022/06/01 - 2026/05/31 Building European Nuclear Competence through continuous Advanced and Structural Education and Training Actions 101061677
101061677
Researcher
EU Framework Programme for Research and Innovation Euratom
Ongoing
2022 - 2025 Development of potent and broadly neutralizing antibodies fragments for COVID-19 derived from domestic cats naturally infected with SARS-CoV-2
PTDC/CVT-CVT/0149/2021
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2021 - 2025 The European medical isotope programme:Production of high purity isotopes by mass separation
Programa H2020; 101008571 PRISMAP
Researcher
Ongoing
2022 - 2024 A molecular and nano approach to target the RANK-TRAF6 interface for bone metastases treatment
PTDC/QUI-OUT/3854/2021
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2021 - 2024 Ruthenium-peptide conjugates: arrows for selectively targeting breast cancer
PTDC/QUI-QIN/0146/2020
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2021 - 2024 Novel nanoplatforms for targeting melanoma with 8-hydroxyquinoline metal complexes
PTDC/QUI-QIN/0586/2020
Researcher
Fundação para a Ciência e a Tecnologia
2021 - 2024 Novel nanoplatforms for targeting melanoma with 8-hydroxyquinoline metal complexes
PTDC/QUI-QIN/0586/2020
Fundação para a Ciência e a Tecnologia
2022/04/01 - 2023/03/31 Theranostic Strategy for Proton Boron Capture Therapy of Pancreatic Cancer
UTAP-EXPL/FMT/0020/2021
Researcher
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2022 Engineering of Smart Exosomes for Amyloid-beta Clearance in Alzheimer disease
PTDC/BTM-SAL/31057/2017
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2022 Novel Molecular Imaging tools for Cystic Fibrosis
PTDC/BTM-TEC/29256/2017
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021 Development of a novel class of antibody-drug conjugates molecules for cancer treatment
PTDC/BTM-SAL/32085/2017
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2016 - 2020 Peptides for blood brain barrier transmigration and drug delivery novel therapies for the central nervous system
FCT-PTDC/BBB-NAN/1578/2014
Researcher
Concluded
2016 - 2019 Overcoming the Brain Drug Delivery Bottleneck: Development of single domain antibodies for brain targeting and drug delivery across the Blood Brain Barrier
FCT-PTDC/BBB-BIO/0508/2014
Researcher
Concluded
2013 - 2018 Molecular and nano tools for cancer theranostics
EXCL/QEQ-MED/0233/2012
Researcher
2014 - 2016 Metal-based Compounds Relevant for Nuclear Medicine Applications
Bilateral Action Portugal/Brasil, FCT-CAPES
Researcher
Concluded
2014 - 2015 Dual Targeting Strategy for EGFR Positive Tumors
EXPL/QEQ-MED/1950/2013
Researcher
Concluded
2012 - 2015 Preclinical evaluation of ruthenium potential drugs for cancer therapy
PTDC/QUI-QUI/118077/2010
Researcher
Concluded
2011 - 2014 Synthesis and Pre-clinical Evaluation of Novel Estradiol-Based Indium Complexes for Targeted Radiotherapy of Tumors
PTDC/QUI-QUI/111891/2009
Principal investigator
Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2014 Synthesis, Characterization and Biological Assessment of Multi-Functional Bone-Seeking Agents
PTDC/QUI-QUI/111891/2009
Researcher
Concluded
2011 - 2014 Albumin binding-domain fusions to improve protein pharmacokinetics
PTDC/SAU-FAR/115846/2009
Researcher
Concluded
2010 - 2012 Radiolabeled Benzazole Derivatives for In vivo Imaging of Amyloid Aggregation
PTDC/QUI-QUI/102049/2008
Researcher
Concluded
2009 - 2012 Chemical, Radiochemical and Biological Studies of Pyrazolyl-Alkylamine Pt(II) Complexes: Application on the Development of Novel Anti-cancer Drugs
PTDC/QUI/66813/2006
Researcher
Concluded
2009 - 2010 Radiosynthesis and Biological Evaluation of Novel Receptor Tyrosine Kinase Inhibitors for In Vivo Targeting of EGFR and VEGFR
FCT/DAAD nº 441.00
Researcher
Concluded
2007 - 2010 Evaluation of Acute Pulmonary Oedema – Development of a New Technique Using Giant Unilamellar Liposomes
PTDC/SAU-BEB/76455/2006
Researcher
Concluded
2006 - 2010 Novel Drugs to Target Bio-Receptors Aimed at Pharmacological Applications
POCI/QUI/56985/2004
Researcher
Concluded
2005 - 2009 Novel Metal Fragments Potentially Useful for Labelling Biologically Relevant Molecules with Tc and/or Re
POCI/QUI/58245/2004
Researcher
Concluded
2005 - 2009 Radiolabelling of L-Arginine Analogues with the fac-99mTc(CO)3+ for Probing Nitric Oxide Synthase (NOS) In Vivo: Synthesis, Characterization and Biological Evaluation
POCI/SAU-FCF/58855/2004
Researcher
Concluded
2007 - 2008 Lanthanide Complexes as Potential Therapeutic Agents: Chemistry, Radiochemistry and Biological Studies
GRICES/Academy of Sciences of the Czech Republic
Researcher
Concluded
2005 - 2008 Novel Estrogen Receptor Ligands as Potential Probes for Targeted Tumour Imaging and Therapy
CIMAGO/FLAD
Principal investigator
Concluded
2002 - 2005 Virtual Radiopharmacy – A mindful Learning Environment
ECShared Cost RTD Action: IST-2001-32291
Principal investigator
Concluded
2002 - 2005 Radiopharmaceuticals for Treatment of Bone Cancer Pain and/ or Therapy Based on Macrocyclic Lanthanide Complexes
POCTI735859/SAU/99
Researcher
Concluded
2002 - 2005 Organometallic Rhenium and Technetium Complexes: Design of Radiopharmaceuticals for Brain Receptor Imaging
POCTI/2001/QUI/42939
Researcher
Concluded
2000 - 2004 Molecular Recognition and Sequestring of Metalic Ions Towards Potential Biomedical Applications
POCTI/35344/QUI/99
Researcher
Concluded
2000 - 2004 Re and Tc Complexes for Peptides Based Radiopharmaceuticals: Chemistry, Radiochemistry and Biological Studies in vivo and in vitro
POCTI735423/Qui/99
Researcher
Concluded
2000 - 2004 Evaluation of the Genotoxic and Antiestrogenic Potential of Triphenylethylene Derivatives and their Metabolites
POCTI/33544/Qui/99
Researcher
Concluded
1996 - 2000 Development of 99mTc labelled somatostatin and evaluation of their radiochemical and biological behavior
A.I.E.A. project 8972/RO
Principal investigator
Concluded
Outputs

Publications

Book
  1. Andrea Santos; Luisa Roldao Pereira; Paolo Turco; Erik Rosa-Rizzotto; Diego Caroli; Alessandro Gubbiotti; Lurdes Gano; et al. Gastrointestinal Molecular Imaging. 2023.
    10.52717/IJDW6277
  2. Marie-Claire Attard; Marius Mada; Zéna Wimana; Lei Li Corrigan; David Gilmore; Daniel Tempesta; Sergio do Carmo; et al. Radiopharmacy: An update. European Association of Nuclear Medicine. 2019.
    10.52717/GXUO4736
Conference paper
  1. 1) R. Cappai, M. A. Santos, K. Chand, L. Gano, M. A. Zoroddu, M. Peana, J. I. Lachowicz, V. M. Nurchi. "Synthesis, chemical and in vivo studies of a new tris-hydroxypyridinone chelating agent". Paper presented in ISMEC, Dijon, 2017.
    Published
  2. 2) Irto A., K. Chand, R. M. Cigala, F. Crea, L. Gano, C. De Stefano, S. Sammartano, M. A. Santos. "Bis-3-hydroxy-4-pyridinones: From the synthesis to the complexation with Al3+ and Fe3+ and the biological assays". Paper presented in ISMEC, Dijon, 2017.
    Published
  3. "67Ga estradiol based complex for breast cancer ER+ imaging: synthesis and preclinical evaluation". 2014.
  4. "A Bifunctional Tripodal Hydroxypyrimidinone-Based Chelator for Metal Decorporation". Paper presented in ISMEC 2013, 2013.
  5. "Estradiol based indium complexes towards the estrogen receptor". Paper presented in ISMEC 2012, 2012.
  6. "Alkylamine-bearing N-heterocyclic chelators for hard metal ions". Paper presented in ISMEC 2012, 2012.
    Published
  7. "A New Tripodal Hydroxypyrimidone Sequestering Agent. Acta of the XXII International Symposia on Metal Complexes". Paper presented in ISMEC 2011, 2011.
  8. "Novel estradiol based metal complexes of Tc-99m for breast cancer imaging". Paper presented in Int Symp. on Technetium and Other Radiometals in Chemistry and Medicine, Technetium and Other Radiometals in Chemistry and Medicine, 2010.
  9. "Technetium(I)-99m tricarbonyl complexes for targeting melanotic melanoma". Paper presented in Int Symp. on Technetium and Other Radiometals in Chemistry and Medicine, Technetium and Other Radiometals in Chemistry and Medicine, 2010.
  10. "2,3-Diamino propionic acid based chelators for labeling biomolecules with 99mTc(I)". Paper presented in Int Symp. on Technetium and Other Radiometals in Chemistry and Medicine, Technetium and Other Radiometals in Chemistry and Medicine, 2010.
  11. "1-Hydroxybisphophonate-containing amino acids for radioactivity delivery". Paper presented in Int Symp. on Technetium and Other Radiometals in Chemistry and Medicine, Technetium and Other Radiometals in Chemistry and Medicine, 2010.
  12. "A new technique to evaluate experimental acute oedema induced by two different drugs using giant unilamellar liposomes". Paper presented in Int Symp. on Technetiedum and Other Radiometals in Chemistry and Medicine, Technetium and Other Radiometals in Chemistry and Medicine, 2010.
  13. "C7- and C17- substituted estrane derivatives as potential cancer diagnostic agentes". Paper presented in 10th. Cross Straits Symp. Materials, Energy and Environmental Engineering, 2008.
  14. "Ring annelated estranes". Paper presented in 9th Cross Straits Symp. Materials, Energy and Environmental Engineering, 2007.
  15. "Labelling of quinazoline and RGD peptides with the [99mTc(OH2)3(CO)3]+ core: Synthesis, characterization and biological evaluation. In: Labelling of Small molecules Using Novel Technetium-99m Cores". Paper presented in CRP on Development of 99mTc Based Small Biomolecules Using Novel 99mTc Cores, 2007.
  16. "Novel Re(I)/ 99mTc tricarbonyl complexes bearing quinazoline moiety as biomarkers for epidermal growth factor receptor positive tumors". Paper presented in 7th International Symposium on Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine, 2006.
  17. "Mixed tetraazamacrocycles with phosphonate pendant arms on the radiochemical and biological behaviour of their 153Sm and 166Ho complexes". Paper presented in 7th International Symposium on Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine, 2006.
  18. "Rhenium(I) and 99mTechnetium(I) tricarbonyl complexes anchored by monoanionic pyrazolyl-based chelators". Paper presented in 7th International Symposium on Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine,, 2006.
  19. "Proceedings of the 13th Symposium on Radiopharmacy and Radiopharmaceuticals". Paper presented in 13th Symposium on Radiopharmacy and Radiopharmaceuticals, 2006.
    Published
  20. "Auger emitters in radiotherapy: Novel estrogen receptor ligands". Paper presented in 13th Symposium on Radiopharmacy and Radiopharmaceuticals, 2006.
  21. "Radiolanthanide complexes with a novel Bis(methylphosphonate) tetraazamacrocycle". Paper presented in 9th International Symposium on Metal Ions in Biology and Medicine, 2006.
  22. "Coadjuvation of a Bis(3-hydroxy-4-pyridinone) with a deferiprone derivative: A new approach for chelation therapy". Paper presented in 9th International Symposium on Metal Ions in Biology and Medicine, 2006.
  23. "Biological evaluation of 153Sm and 166Ho complexes with macrocyclic ligands containing pendant arms as potential agents for therapy". Paper presented in ISTR 2005, 2005.
    Published
  24. "Radiopharmaceuticals for targeted radiotherapy". Paper presented in 10th International Conference on Radiation Shielding, 2004.
    Published
  25. "A new bis-(3-hydroxy-4-pyridinone) with potential clinical application. Solution chemistry and biodistribution of Ga(III) complexes". Paper presented in 8th International Symposium on Metal Ions in Biology and Medicine, 2004.
    Published
  26. "Complexation of N-carboxyalkyl derivatives of 3-hydroxy-4-pyridinones with Fe(III), Al(III), Ga(III) and In(III). Studies in vitro and in vivo". Paper presented in 7th International Symposium on Metal Ions in Biology and Medicine, 2002.
  27. "New building blocks for labeling peptides with the 99mTc(CO)3+ Core". Paper presented in 6th International Symposium on Technetium in Chemistry and Nuclear Medicine, 2002.
    Published
  28. Gano, Lurdes. "Tc Oxocomplexes with the PNO/S and PNS/S donor atom sets: Labelling of a 5HT1A receptor-binding ligand". Paper presented in 14th International Symposium on Radiopharmaceutical Chemistry, 2001.
    http://onlinelibrary.wiley.com/doi/10.1002/jlcr.25804401184/epdf
  29. "Development of 99mTc labelled somatostatin analogues and evaluation of their radiochemical and biological behaviour". 2001.
  30. "Chelating properties towards Fe(III), Al(III) and Ga(III) and biological evaluation of two N-substituted 3-hydroxy-4-pyridinones". Paper presented in 6th International Symposium on Metal Ions in Biology and Medicine, 2000.
    Published
  31. "Ciprofloxacin in imaging of infective versus sterile inflammation". Paper presented in International Symposium on Modern Trends in Radiopharmaceuticals for Diagnosis and Therapy, 1998.
  32. "Technetium-99m labelling of ior-CEA-1 monoclonal antibody: Evaluation of different methods". 1996.
  33. "Characterization and biodistribution of 99mTc Oxo and nitrido complexes of biguanide-derived ligands". Paper presented in 4th International Symposium on Technetium in Chemistry and Nuclear Medicine, 1995.
Conference poster
  1. F. Silva, C. Mendes, A. D’Onofrio, M. P. Cabral Campello, F.Marques, T. Pinheiro, K. Gonçalves, S. Figueiredo, L. Gano,. "Gold Nanoparticles for Image-Guided delivery of Pt(IV) Prodrugs to Gastrin-Releasing Peptide Receptor Positive Cancers". Paper presented in International Symposium on Modern Trends in Radiopharmaceuticals for Diagnosis and Therapy, 2023.
  2. "More than 150 poster communications presented in national and international meetings". 2022.
Journal article
  1. Ana S. André; Joana N. R. Dias; Sandra I. Aguiar; Ana Leonardo; Sara Nogueira; Joana D. Amaral; Célia Fernandes; et al. "Panobinostat-loaded folate targeted liposomes as a promising drug delivery system for treatment of canine B-cell lymphoma". Frontiers in Veterinary Science (2023): http://dx.doi.org/10.3389/fvets.2023.1236136.
    10.3389/fvets.2023.1236136
  2. Ana S. André; Joana N. R. Dias; Sandra Aguiar; Sara Nogueira; Pedro Bule; Joana Inês Carvalho; João P. M. António; et al. "Rabbit derived VL single-domains as promising scaffolds to generate antibody–drug conjugates". Scientific Reports 13 1 (2023): http://dx.doi.org/10.1038/s41598-023-31568-x.
    10.1038/s41598-023-31568-x
  3. Jacinta O. Pinho; Mariana Matias; Vanda Marques; Carla Eleutério; Célia Fernandes; Lurdes Gano; Joana D. Amaral; et al. "Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management". Biomedicine & Pharmacotherapy 157 (2023): 114021-114021. http://dx.doi.org/10.1016/j.biopha.2022.114021.
    10.1016/j.biopha.2022.114021
  4. Francisco Silva; Carolina Mendes; Alice D'Onofrio; Maria Paula Cabral Campello; Fernanda Marques; Teresa Pinheiro; Kyle Gonçalves; et al. "Image-Guided Nanodelivery of Pt(IV) Prodrugs to GRP-Receptor Positive Tumors". Nanotheranostics 7 1 (2023): 22-40. http://dx.doi.org/10.7150/ntno.78807.
    10.7150/ntno.78807
  5. Alice D’Onofrio; Francisco Silva; Lurdes Gano; Paula Raposinho; Célia Fernandes; Arkadiusz Sikora; Monika Wyczólkowska; et al. "Bioorthogonal Chemistry Approach for the Theranostics of GRPR-Expressing Cancers". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14122569.
    10.3390/pharmaceutics14122569
  6. "The HIV-1 Matrix Protein p17 Does Cross the Blood-Brain Barrier". Journal of Virology 96 1 (2022): http://dx.doi.org/10.1128/jvi.01200-21.
    10.1128/jvi.01200-21
  7. Silvia Chaves; Karolina Gwizdala; Karam Chand; Lurdes Gano; Agnès Pallier; Éva Tóth; M. Amélia Santos. "GdIII and GaIII complexes with a new tris-3,4-HOPO ligand as new imaging probes: complex stability, magnetic properties and biodistribution". Dalton Transactions 51 16 (2022): 6436-6447. https://doi.org/10.1039/D2DT00066K.
    10.1039/D2DT00066K
  8. Sandra Isabel Aguiar; Joana N. R. Dias; Ana André; Marta Lisete Silva; Diana Martins; Belmira Carrapiço; Miguel Castanho; et al. "Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening". Pharmaceutics (2021): https://www.mdpi.com/1999-4923/13/10/1598.
    10.3390/pharmaceutics13101598
  9. "Bioconjugate Supramolecular Pd2+ Metallacages Penetrate the Blood Brain Barrier In Vitro and In Vivo". Bioconjugate Chemistry 32 7 (2021): 1399-1408. http://dx.doi.org/10.1021/acs.bioconjchem.0c00659.
    10.1021/acs.bioconjchem.0c00659
  10. "Clickable Radiocomplexes With Trivalent Radiometals for Cancer Theranostics: In vitro and in vivo Studies". frontiers in medicine (2021):
    doi: 10.3389/fmed.2021.647379
  11. D'Onofrio, Alice; Gano, Lurdes; Melo, Rita; Mendes, Filipa; Oliveira, Maria Cristina; Denoël, Thibaut; Schaefer, Niklaus; et al. "Biological evaluation of new TEM1 targeting recombinant antibodies for radioimmunotherapy: In vitro, in vivo and in silico studies". European Journal of Pharmaceutics and Biopharmaceutics 158 (2021): 233-244. http://dx.doi.org/10.1016/j.ejpb.2020.11.015.
    10.1016/j.ejpb.2020.11.015
  12. Prado, Viviana S.; Leitao, Renan C. F.; Silva, Francisco; Gano, Lurdes; Santos, Isabel C.; Marques, Fabio L. N.; Paulo, António; Deflon, Victor M.. "Gallium and indium complexes with new hexadentate bis(semicarbazone) and bis(thiosemicarbazone) chelators". Dalton Transactions 50 5 (2021): 1631-1640. http://dx.doi.org/10.1039/d0dt04028b.
    10.1039/d0dt04028b
  13. Cadima-Couto, Iris; Tauzin, Alexandra; Freire, João M.; Figueira, Tiago N.; Silva, Rúben D. M.; Pérez-Peinado, Clara; Cunha-Santos, Catarina; et al. "Anti-HIV-1 Activity of pepRF1, a Proteolysis-Resistant CXCR4 Antagonist Derived from Dengue Virus Capsid Protein". ACS Infectious Diseases 7 1 (2020): 6-22. http://dx.doi.org/10.1021/acsinfecdis.9b00507.
    10.1021/acsinfecdis.9b00507
  14. Ferreira, Vera F. C.; Oliveira, Bruno L.; D’Onofrio, Alice; Farinha, Carlos M.; Gano, Lurdes; Paulo, António; Bernardes, Gonçalo J. L.; Mendes, Filipa. "In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry". Bioconjugate Chemistry 32 1 (2020): 121-132. http://dx.doi.org/10.1021/acs.bioconjchem.0c00551.
    Published • 10.1021/acs.bioconjchem.0c00551
  15. Gano, Lurdes. "Docetaxel-loaded block copolymer micelles labeled with 188Re for combined radiochemotherapy". Journal of Drug Delivery Science and Technology 60 (2020): 101898-101898. http://dx.doi.org/10.1016/j.jddst.2020.101898.
    10.1016/j.jddst.2020.101898
  16. Gano, Lurdes. "Chemical and biological studies of Re(I)/Tc(I) thiosemicarbazonate complexes relevant for the design of radiopharmaceuticals". Journal of Inorganic Biochemistry (2020): http://dx.doi.org/10.1016/j.jinorgbio.2019.110917.
    10.1016/j.jinorgbio.2019.110917
  17. Silva, Francisco; Paulo, António; Pallier, Agnès; Même, Sandra; Tóth, Éva; Gano, Lurdes; Marques, Fernanda; et al. "Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics". Materials 13 3 (2020): 513. http://dx.doi.org/10.3390/ma13030513.
    10.3390/ma13030513
  18. Mendes, Filipa. "Imaging probes for non-invasive tumoral detection and functional monitoring of cancer multidrug resistance". Cancer Drug Resistance (2020): http://dx.doi.org/10.20517/cdr.2019.86.
    10.20517/cdr.2019.86
  19. Gano, Lurdes. "Antitumour and Toxicity Evaluation of a Ru(II)-Cyclopentadienyl Complex in a Prostate Cancer Model by Imaging Tools". Anti-Cancer Agents in Medicinal Chemistry (2019): http://dx.doi.org/10.2174/1871520619666190318152726.
    10.2174/1871520619666190318152726
  20. Gano, Lurdes. "A new bis-(3-hydroxy-4-pyridinone)-DTPA-derivative: Synthesis, complexation of di-/tri-valent metal cations and in vivo M3+ sequestering ability". Journal of Molecular Liquids (2019): http://dx.doi.org/10.1016/j.molliq.2019.02.042.
    10.1016/j.molliq.2019.02.042
  21. Valeria M. Nurchi; Maria de Guadalupe Jaraquemada-Pelaez; Guido Crisponi; Joanna I. Lachowicz; Rosita Cappai; Lurdes Gano; M. Amelia Santos; et al. "A new tripodal kojic acid derivative for iron sequestration: Synthesis, protonation, complex formation studies with Fe3+, Al3+, Cu2+ and Zn2+, and in vivo bioassays". Journal of Inorganic Biochemistry 193 (2019): 152-165. https://doi.org/10.1016/j.jinorgbio.2019.01.012.
    10.1016/j.jinorgbio.2019.01.012
  22. Valeria M. Nurchi; Rosita Cappai; Karam Chand; Sílvia Chaves; Lurdes Gano; Guido Crisponi; Massimiliano Peana; M. Antonietta Zoroddu; M. Amélia Santos. "New strong extrafunctionalizable tris(3,4-HP) and bis(3,4-HP) metal sequestering agents: synthesis, solution and in vivo metal chelation". Dalton Transactions (2019): https://doi.org/10.1039/C9DT02905B.
    10.1039/C9DT02905B
  23. Gano, Lurdes. "Establishment of a bioluminescent canine B-cell lymphoma xenograft model for monitoring tumor progression and treatment response in preclinical studies". PLOS ONE (2018): http://dx.doi.org/10.1371/journal.pone.0208147.
    10.1371/journal.pone.0208147
  24. Gano, Lurdes. "New bis-(3-hydroxy-4-pyridinone)-NTA-derivative: Synthesis, binding ability towards Ca2+, Cu2+, Zn2+, Al3+, Fe3+ and biological assays". Journal of Molecular Liquids (2018): http://dx.doi.org/10.1016/j.molliq.2018.09.107.
    10.1016/j.molliq.2018.09.107
  25. Anna Irto; Paola Cardiano; Karam Chand; Rosalia Maria Cigala; Francesco Crea; Concetta De Stefano; Lurdes Gano; Silvio Sammartano; Maria Amélia Santos. "Bifunctional 3-hydroxy-4-pyridinones as effective aluminium chelators: synthesis, solution equilibrium studies and in vivo evaluation". Journal of Inorganic Biochemistry 186 (2018): 116-129. https://doi.org/10.1016/j.jinorgbio.2018.05.017.
    10.1016/j.jinorgbio.2018.05.017
  26. Dias, Joana N.R.; Aguiar, Sandra I.; Pereira, Diane M.; André, Ana S.; Gano, Lurdes; Correia, João D.G.; Carrapiço, Belmira; et al. "The histone deacetylase inhibitor panobinostat is a potent antitumor agent in canine diffuse large B-cell lymphoma". Oncotarget 9 47 (2018): http://dx.doi.org/10.18632/oncotarget.25580.
    10.18632/oncotarget.25580
  27. Rosita Cappai; Karam Chand; Joanna I. Lachowicz; Sílvia Chaves; Lurdes Gano; Guido Crisponi; Valeria M. Nurchi; et al. "A new tripodal-3-hydroxy-4-pyridinone for iron and aluminium sequestration: synthesis, complexation and in vivo studies". New Journal of Chemistry (2018): https://doi.org/10.1039/C8NJ00116B.
    10.1039/C8NJ00116B
  28. Filipe Vultos; Célia Fernandes; Filipa Mendes; Fernanda Marques; João D. G. Correia; Isabel Santos; Lurdes Gano. "A Multifunctional Radiotheranostic Agent for Dual Targeting of Breast Cancer Cells". ChemMedChem 12 14 (2017): 1103-1107. https://doi.org/10.1002%2Fcmdc.201700287.
    10.1002/cmdc.201700287
  29. Gano, Lurdes. "In Vitro/In Vivo “Peeling” of Multilayered Aminocarboxylate Gold Nanoparticles Evidenced by a Kinetically Stable 99mTclabel: Implications for Glutathione-mediated Drug Release". Dalton Trans (2017): http://10.1039/c7dt00864c.
    10.1039/c7dt00864c
  30. Neves, V.; Aires-Da-Silva, F.; Morais, M.; Gano, L.; Ribeiro, E.; Pinto, A.; Aguiar, S.; et al. "Novel Peptides Derived from Dengue Virus Capsid Protein Translocate Reversibly the Blood-Brain Barrier through a Receptor-Free Mechanism". ACS Chemical Biology 12 5 (2017): 1257-1268. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019592875&partnerID=MN8TOARS.
    10.1021/acschembio.7b00087
  31. Cantante, C.; Lourenço, S.; Morais, M.; Leandro, J.; Gano, L.; Silva, N.; Leandro, P.; et al. "Albumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins". Journal of Biotechnology 253 (2017): 23-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019767367&partnerID=MN8TOARS.
    10.1016/j.jbiotec.2017.05.017
  32. Morais, G.R.; Palma, E.; Marques, F.; Gano, L.; Oliveira, M.C.; Abrunhosa, A.; Miranda, H.V.; et al. "Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents". Journal of Heterocyclic Chemistry 54 1 (2017): 255-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952673515&partnerID=MN8TOARS.
    10.1002/jhet.2575
  33. Océane Florès; Audrey Trommenschlager; Souheila Amor; Fernanda Marques; Francisco Silva; Lurdes Gano; Franck Denat; et al. "In vitro and in vivo trackable titanocene-based complexes using optical imaging or SPECT". Dalton Transactions 46 42 (2017): 14548-14555. https://doi.org/10.1039/C7DT01981E.
    10.1039/C7DT01981E
  34. Bihari, Z.; Vultos, F.; Fernandes, C.; Gano, L.; Santos, I.; Correia, J.D.G.; Buglyó, P.. "Synthesis, characterization and biological evaluation of a 67Ga-labeled (¿6-Tyr)Ru(¿5-Cp) peptide complex with the HAV motif". Journal of Inorganic Biochemistry 160 (2016): 189-197. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958568371&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2016.02.011
  35. Oliveira, M.C.; Gano, L.; Santos, I.; Correia, J.D.G.; Serrano, I.D.; Santos, S.S.; Ribeiro, M.; et al. "Improvement of the pharmacological properties of amidated kyotorphin by means of iodination". MedChemComm 7 5 (2016): 906-913. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971246172&partnerID=MN8TOARS.
    10.1039/c6md00028b
  36. Ribeiro, E.; Alho, I.; Marques, F.; Gano, L.; Correia, I.; Correia, J.D.G.; Casimiro, S.; et al. "Radiolabeled block copolymer micelles for image-guided drug delivery". International Journal of Pharmaceutics 515 1-2 (2016): 692-701. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994560511&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2016.11.004
  37. Fernandes, C.; Monteiro, S.; Belchior, A.; Marques, F.; Gano, L.; Correia, J.D.G.; Santos, I.. "Novel 188Re multi-functional bone-seeking compounds: Synthesis, biological and radiotoxic effects in metastatic breast cancer cells". Nuclear Medicine and Biology 43 2 (2016): 150-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958225304&partnerID=MN8TOARS.
    10.1016/j.nucmedbio.2015.11.004
  38. Jasem, Y.A.; Thiemann, T.; Gano, L.; Oliveira, M.C.. "Fluorinated steroids and their derivatives". Journal of Fluorine Chemistry 185 (2016): 48-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962226693&partnerID=MN8TOARS.
    10.1016/j.jfluchem.2016.03.009
  39. Lachowicz, J.I.; Nurchi, V.M.; Crisponi, G.; Jaraquemada-Pelaez, M.G.; Arca, M.; Pintus, A.; Santos, M.A.; et al. "Hydroxypyridinones with enhanced iron chelating properties. Synthesis, characterization and in vivo tests of 5-hydroxy-2-(hydroxymethyl)pyridine- 4(1H)-one". Dalton Transactions 45 15 (2016): 6517-6528. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964663124&partnerID=MN8TOARS.
    10.1039/c6dt00129g
  40. Silva, F.; Zambre, A.; Campello, M.P.C.; Gano, L.; Santos, I.; Ferraria, A.M.; Ferreira, M.J.; et al. "Interrogating the Role of Receptor-Mediated Mechanisms: Biological Fate of Peptide-Functionalized Radiolabeled Gold Nanoparticles in Tumor Mice". Bioconjugate Chemistry 27 4 (2016): 1153-1164. http://www.scopus.com/inward/record.url?eid=2-s2.0-84965104329&partnerID=MN8TOARS.
    10.1021/acs.bioconjchem.6b00102
  41. Vultos, F.; Cunha, S.; Fernandes, C.; Oliveira, M.C.; Marques, F.; Botelho, M.F.; Santos, I.; Gano, L.. "New estradiol based 111In complex towards the estrogen receptor". Radiochimica Acta 103 11 (2015): 765-776. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946206468&partnerID=MN8TOARS.
    10.1515/ract-2014-2355
  42. Silva, F.; Campello, M.P.C.; Gano, L.; Fernandes, C.; Santos, I.; Santos, I.C.; Ascenso, J.R.; João Ferreira, M.; Paulo, A.. "Chemical, radiochemical and biological studies of new gallium(iii) complexes with hexadentate chelators". Dalton Transactions 44 7 (2015): 3342-3355. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922643996&partnerID=MN8TOARS.
    10.1039/c4dt02274b
  43. Nunes, P.; Morais, G.R.; Palma, E.; Silva, F.; Oliveira, M.C.; Ferreira, V.F.C.; Mendes, F.; et al. "Isostructural Re(i)/<sup>99m</sup>Tc(i) tricarbonyl complexes for cancer theranostics". Organic and Biomolecular Chemistry 13 18 (2015): 5182-5194. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928905685&partnerID=MN8TOARS.
    10.1039/c5ob00124b
  44. Oliveira, B.L.; Morais, M.; Gano, L.; Santos, I.; Correia, J.D.G.. "A 99mTc(CO)3-labeled benzylguanidine with persistent heart uptake". Journal of Labelled Compounds and Radiopharmaceuticals 57 5 (2014): 358-364. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901585470&partnerID=MN8TOARS.
    10.1002/jlcr.3188
  45. Morais, M.; Cantante, C.; Gano, L.; Santos, I.; Lourenço, S.; Santos, C.; Fontes, C.; et al. "Biodistribution of a 67Ga-labeled anti-TNF VHH single-domain antibody containing a bacterial albumin-binding domain (Zag)". Nuclear Medicine and Biology 41 S (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899084462&partnerID=MN8TOARS.
    10.1016/j.nucmedbio.2014.01.009
  46. Adriaenssens, L.; Liu, Q.; Chaux-Picquet, F.; Tasan, S.; Picquet, M.; Denat, F.; Le Gendre, P.; et al. "Novel heterobimetallic radiotheranostic: Preparation, activity, and biodistribution". ChemMedChem 9 7 (2014): 1567-1573. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903819569&partnerID=MN8TOARS.
    10.1002/cmdc.201300494
  47. Gano, Lurdes. "Re(I) and 99mTc(I) tricarbonyl complexes with ether-containing pyrazolyl-based chelators: Chemistry, biodistribution and metabolism". Journal of Organometallic Chemistry (2014):
    http://dx.doi.org/10.1016/j.jorganchem.2013.11.013
  48. Gano, Lurdes. "Biological assessment of novel bisphosphonate-containing 99mTc/Reorganometallic complexes". Journal of Organometallic Chemistry 760 (2014) 197e204 (2014):
    http://dx.doi.org/10.1016/j.jorganchem.2013.10.038
  49. Toso, L.; Crisponi, G.; Nurchi, V.M.; Crespo-Alonso, M.; Lachowicz, J.I.; Mansoori, D.; Arca, M.; et al. "Searching for new aluminium chelating agents: A family of hydroxypyrone ligands". Journal of Inorganic Biochemistry 130 1 (2014): 112-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887066767&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2013.09.022
  50. Chaves, S.; Capelo, A.; Areias, L.; Marques, S.M.; Gano, L.; Esteves, M.A.; Santos, M.A.. "A novel tripodal tris-hydroxypyrimidinone sequestering agent for trivalent hard metal ions: Synthesis, complexation and in vivo studies". Dalton Transactions 42 17 (2013): 6033-6045. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875801298&partnerID=MN8TOARS.
    10.1039/c2dt32361c
  51. Ribeiro Morais, G.; Gano, L.; Kniess, T.; Bergmann, R.; Abrunhosa, A.; Santos, I.; Paulo, A.. "Radiosynthesis and in vivo evaluation of a 18F-labelled styryl-benzoxazole derivative for ß-amyloid targeting". Applied Radiation and Isotopes 82 (2013): 100-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883032318&partnerID=MN8TOARS.
    10.1016/j.apradiso.2013.07.003
  52. Mendes, F.; Gano, L.; Fernandes, C.; Paulo, A.; Santos, I.. "Perfusion and specific radioprobes for cardiac imaging". CARDIOTECHNIX 2013 - Proceedings of the International Congress on Cardiovascular Technologies (2013): 79-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887219380&partnerID=MN8TOARS.
  53. Morais, M.; Paulo, A.; Gano, L.; Santos, I.; Correia, J.D.G.. "Target-specific Tc(CO)3-complexes for in vivo imaging". Journal of Organometallic Chemistry 744 (2013): 125-139. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884533667&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2013.05.050
  54. Moura, C.; Mendes, F.; Gano, L.; Santos, I.; Paulo, A.. "Mono- and dicationic Re(I)/99mTc(I) tricarbonyl complexes for the targeting of energized mitochondria". Journal of Inorganic Biochemistry 123 (2013): 34-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874931259&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2013.02.008
  55. Cunha, S.; Gano, L.; Ribeiro Morais, G.; Thiemann, T.; Oliveira, M.C.. "Progesterone receptor targeting with radiolabelled steroids: An approach in predicting breast cancer response to therapy". Journal of Steroid Biochemistry and Molecular Biology 137 (2013): 223-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886720304&partnerID=MN8TOARS.
    10.1016/j.jsbmb.2013.04.003
  56. Oliveira, M.C.; Neto, C.; Gano, L.; Marques, F.; Santos, I.; Thiemann, T.; Santos, A.C.; Botelho, F.; Oliveira, C.F.. "Estrogen receptor ligands for targeting breast tumours: A brief outlook on radioiodination strategies". Current Radiopharmaceuticals 5 2 (2012): 124-141. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857132356&partnerID=MN8TOARS.
    10.2174/1874471011205020124
  57. Mendes, F.; Gano, L.; Fernandes, C.; Paulo, A.; Santos, I.. "Studies of the myocardial uptake and excretion mechanisms of a novel 99mTc heart perfusion agent". Nuclear Medicine and Biology 39 2 (2012): 207-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856362049&partnerID=MN8TOARS.
    10.1016/j.nucmedbio.2011.08.007
  58. Neto, C.; Fernandes, C.; Oliveira, M.C.; Gano, L.; Mendes, F.; Kniess, T.; Santos, I.. "Radiohalogenated 4-anilinoquinazoline-based EGFR-TK inhibitors as potential cancer imaging agents". Nuclear Medicine and Biology 39 2 (2012): 247-260. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856346831&partnerID=MN8TOARS.
    10.1016/j.nucmedbio.2011.09.001
  59. Caballero, J.; Muñoz, C.; Alzate-Morales, J.H.; Cunha, S.; Gano, L.; Bergmann, R.; Steinbach, J.; Kniess, T.. "Synthesis, in silico, in vitro, and in vivo investigation of 5-[ 11C]methoxy-substituted sunitinib, a tyrosine kinase inhibitor of VEGFR-2". European Journal of Medicinal Chemistry 58 (2012): 272-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868248820&partnerID=MN8TOARS.
    10.1016/j.ejmech.2012.10.020
  60. Neto, C.; Oliveira, M.C.; Gano, L.; Marques, F.; Yasuda, T.; Thiemann, T.; Kniess, T.; Santos, I.. "Novel 7a-alkoxy-17a-(4'-halophenylethynyl)estradiols as potential SPECT/PET imaging agents for estrogen receptor expressing tumours: Synthesis and binding affinity evaluation". Steroids 77 11 (2012): 1123-1132. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865491838&partnerID=MN8TOARS.
    10.1016/j.steroids.2012.05.004
  61. Neto, C.; Oliveira, M.C.; Gano, L.; Marques, F.; Thiemann, T.; Santos, I.. "Novel estradiol based metal complexes of Tc-99m". Journal of Inorganic Biochemistry 111 (2012): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860528917&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2012.03.001
  62. Kuchar, M.; Oliveira, M.C.; Gano, L.; Santos, I.; Kniess, T.. "Radioiodinated sunitinib as a potential radiotracer for imaging angiogenesis - Radiosynthesis and first radiopharmacological evaluation of 5-[ 125I]Iodo-sunitinib". Bioorganic and Medicinal Chemistry Letters 22 8 (2012): 2850-2855. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859438032&partnerID=MN8TOARS.
    10.1016/j.bmcl.2012.02.068
  63. Santos, A.C.; Matos, C.M.; Oliveiros, B.; Almeida, T.; Gano, L.; Neves, M.; Ferreira, N.. "Thermolabile liposomes: A controlled release delivery tool in diagnosis/therapy in experimental pulmonary oedema". Current Radiopharmaceuticals 5 2 (2012): 166-174. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857128664&partnerID=MN8TOARS.
    10.2174/1874471011205020166
  64. Moura, C.; Gano, L.; Mendes, F.; Raposinho, P.D.; Abrantes, A.M.; Botelho, M.F.; Santos, I.; Paulo, A.. "99mTc(I)/Re(I) tricarbonyl complexes for in vivo targeting of melanotic melanoma: Synthesis and biological evaluation". European Journal of Medicinal Chemistry 50 (2012): 350-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858449323&partnerID=MN8TOARS.
    10.1016/j.ejmech.2012.02.014
  65. Moura, C.; Gano, L.; Santos, I.C.; Paulo, A.; Santos, I.. "99mTc(I) scorpionate complexes for brain imaging: Synthesis, characterization and biological evaluation". Current Radiopharmaceuticals 5 2 (2012): 150-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857129797&partnerID=MN8TOARS.
    10.2174/1874471011205020150
  66. Moura, C.; Gano, L.; Santos, I.; Santos, I.C.; Paulo, A.. "99mTcI/ReI tricarbonyl complexes with tridentate cysteamine based ligands: Synthesis, characterization and in vitro/in vivo evaluation". European Journal of Inorganic Chemistry 35 (2011): 5405-5413. http://www.scopus.com/inward/record.url?eid=2-s2.0-82955245710&partnerID=MN8TOARS.
    10.1002/ejic.201100796
  67. Palma, E.; Correia, J.D.G.; Oliveira, B.L.; Gano, L.; Santos, I.C.; Santos, I.. "99mTc(CO)3-labeled pamidronate and alendronate for bone imaging". Dalton Transactions 40 12 (2011): 2787-2796. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952647633&partnerID=MN8TOARS.
    10.1039/c0dt01396j
  68. Neves, M.; Teixeira, F.C.; Antunes, I.; Majkowska, A.; Gano, L.; Santos, A.C.. "Chemical and biological evaluation of 153Sm and 46/47Sc complexes of indazolebisphosphonates for targeted radiotherapy". Applied Radiation and Isotopes 69 1 (2011): 80-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958460858&partnerID=MN8TOARS.
    10.1016/j.apradiso.2010.09.015
  69. Gano, Lurdes. "Rapid hepatic clearance of 99mTc-TMEOP: a new candidate for myocardial perfusion imaging". (2011):
    10.1002/cmmi.413
  70. Lima, L.M.P.; Delgado, R.; Marques, F.; Gano, L.; Santos, I.. "TETA analogue containing one methylenephosphonate pendant arm: Lanthanide complexes and biological evaluation of its 153Sm and 166Ho complexes". European Journal of Medicinal Chemistry 45 12 (2010): 5621-5627. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649318835&partnerID=MN8TOARS.
    10.1016/j.ejmech.2010.09.013
  71. Moura, C.; Esteves, T.; Gano, L.; Raposinho, P.D.; Paulo, A.; Santos, I.. "Synthesis, characterization and biological evaluation of tricarbonyl M(i) (M = Re, 99mTc) complexes functionalized with melanin-binding pharmacophores". New Journal of Chemistry 34 11 (2010): 2564-2578. http://www.scopus.com/inward/record.url?eid=2-s2.0-78049263952&partnerID=MN8TOARS.
    10.1039/c0nj00256a
  72. Chaves, S.; Marques, S.M.; Matos, A.M.F.; Nunes, A.; Gano, L.; Tuccinardi, T.; Martinelli, A.; Amélia Santos, M.. "New tris(hydroxypyridinones) as iron and aluminium sequestering agents: Synthesis, complexation and in vivo studies". Chemistry - A European Journal 16 34 (2010): 10535-10545. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956449631&partnerID=MN8TOARS.
    10.1002/chem.201001335
  73. Garcia, R.; Kubícek, V.; Draho, B.; Gano, L.; Santos, I.C.; Campello, P.; Paulo, A.; Tóth, E.; Santos, I.. "Synthesis, characterization and biological evaluation of In(iii) complexes anchored by DOTA-like chelators bearing a quinazoline moiety". Metallomics 2 8 (2010): 571-580. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955358453&partnerID=MN8TOARS.
    10.1039/c004797j
  74. Lacerda, S.; Marques, F.; Campello, P.; Gano, L.; Kubícek, V.; Hermann, P.; Santos, I.. "Chemical, radiochemical and biological studies of Sm and Ho complexes of H4dota analogues containing one methylphosphonic/phosphinic acid pendant arm". Journal of Labelled Compounds and Radiopharmaceuticals 53 1 (2010): 36-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-76249129110&partnerID=MN8TOARS.
    10.1002/jlcr.1697
  75. Grazina, R.; Gano, L.; Šebestík, J.; Amelia Santos, M.. "New tripodal hydroxypyridinone based chelating agents for Fe(III), Al(III) and Ga(III): Synthesis, physico-chemical properties and bioevaluation". Journal of Inorganic Biochemistry 103 2 (2009): 262-273. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149505729&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2008.10.014
  76. Gama, S.; Gil, M.; Gano, L.; Farkas, E.; Amélia Santos, M.. "Combined chelation of bi-functional bis-hydroxypiridinone and mono-hydroxypiridinone: Synthesis, solution and in vivo evaluation". Journal of Inorganic Biochemistry 103 2 (2009): 288-298. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149498315&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2008.10.020
  77. Neto, C.; Oliveira, M.C.; Gano, L.; Marques, F.; Santos, I.; Morais, G.R.; Yasuda, T.; et al. "Radioiodinated ligands for the estrogen receptor: Effect of different 7-cyanoalkyl chains on the binding affinity of novel iodovinyl-6-dehydroestradiols". Applied Radiation and Isotopes 67 2 (2009): 301-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-58049153116&partnerID=MN8TOARS.
    10.1016/j.apradiso.2008.10.005
  78. Garcia, R.; Fousková, P.; Gano, L.; Paulo, A.; Campello, P.; Tóth, É.; Santos, I.. "A quinazoline-derivative DOTA-type gallium(III) complex for targeting epidermal growth factor receptors: Synthesis, characterisation and biological studies". Journal of Biological Inorganic Chemistry 14 2 (2009): 261-271. http://www.scopus.com/inward/record.url?eid=2-s2.0-58949100316&partnerID=MN8TOARS.
    10.1007/s00775-008-0446-8
  79. Santos, I.; Maria, L.; Fernandes, C.; Garcia, R.; Gano, L.; Paulo, A.; Santos, I.C.. "Tris(pyrazolyl)methane 99mTc tricarbonyl complexes for myocardial imaging". Dalton Transactions 4 (2009): 603-606. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149513007&partnerID=MN8TOARS.
    10.1039/b817451b
  80. Neto, C.; Oliveira, M.C.; Gano, L.; Marques, F.; Santos, I.; Morais, G.; Yasuda, T.; et al. "Evaluation of novel radioiodinated C7-substituted ¿6,7-estradiol derivatives for molecular recognition of er-positive breast tumours". Current Radiopharmaceuticals 2 2 (2009): 83-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-68149090478&partnerID=MN8TOARS.
    10.2174/1874471010902020083
  81. Chaves, S.; Dron, P.I.; Danalache, F.A.; Sacoto, D.; Gano, L.; Santos, M.A.. "Combined chelation based on glycosyl-mono- and bis-hydroxypyridinones for aluminium mobilization: Solution and biodistribution studies". Journal of Inorganic Biochemistry 103 11 (2009): 1521-1529. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350004070&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2009.07.026
  82. Lacerda, S.; Campello, M.P.; Marques, F.; Gano, L.; Kubíek, V.; Fousková, P.; Tóth, E.; Santos, I.. "A novel tetraazamacrocycle bearing a thiol pendant arm for labeling biomolecules with radiolanthanides". Dalton Transactions 23 (2009): 4509-4518. http://www.scopus.com/inward/record.url?eid=2-s2.0-67749147121&partnerID=MN8TOARS.
    10.1039/b820375j
  83. Moura, C.; Fernandes, C.; Gano, L.; Paulo, A.; Santos, I.C.; Santos, I.; Calhorda, M.J.. "Influence of the ligand donor atoms on the in vitro stability of rhenium(I) and technetium (I)-99m complexes with pyrazole-containing chelators: Experimental and DFT studies". Journal of Organometallic Chemistry 694 6 (2009): 950-958. http://www.scopus.com/inward/record.url?eid=2-s2.0-60749132724&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2008.11.027
  84. Marques, F.; Gano, L.; Batista, M.K.S.; Gomes, C.A.R.; Gomes, P.; Santos, I.. "Radiochemical and biological evaluation of novel 153Sm/ 166Ho-amino acid-chitosan complexes". Journal of Labelled Compounds and Radiopharmaceuticals 52 3 (2009): 79-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-62849096351&partnerID=MN8TOARS.
    10.1002/jlcr.1571
  85. Xavier, C.; Giannini, C.; Gano, L.; Maiorana, S.; Alberto, R.; Santos, I.. "Synthesis, characterization, and evaluation of a novel 99mTc(CO) 3 pyrazolyl conjugate of a peptide nucleic acid sequence". Journal of Biological Inorganic Chemistry 13 8 (2008): 1335-1344. http://www.scopus.com/inward/record.url?eid=2-s2.0-55949120077&partnerID=MN8TOARS.
    10.1007/s00775-008-0419-y
  86. Försterová, M.; Jandurová, Z.; Marques, F.; Gano, L.; Lubal, P.; Vanek, J.; Hermann, P.; Santos, I.. "Chemical and biological evaluation of 153Sm and 166Ho complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H4dotpOEt)". Journal of Inorganic Biochemistry 102 7 (2008): 1531-1540. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649181534&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2008.02.002
  87. Santos, M.A.; Gama, S.; Gil, M.; Gano, L.. "A new approach for potential combined chelation therapy using mono- and bis-hydroxypyridinones". Hemoglobin 32 1-2 (2008): 147-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-39349108152&partnerID=MN8TOARS.
    10.1080/03630260701726939
  88. Maria, L.; Cunha, S.; Videira, M.; Gano, L.; Paulo, A.; Santos, I.; Santos, I.C.. "Rhenium and technetium tricarbonyl complexes anchored by pyrazole-based tripods: Novel lead structures for the design of myocardial imaging agents". Dalton Transactions 28 (2007): 3010-3019. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547293218&partnerID=MN8TOARS.
    10.1039/b705226j
  89. Marques, F.; Gano, L.; Campello, M.P.; Lacerda, S.; Santos, I.. "Biological evaluation of 153Sm and 166Ho complexes with tetraazamacrocycles containing methylcarboxylate and/or methylphosphonate pendant arms". Radiochimica Acta 95 6 (2007): 335-341. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250729721&partnerID=MN8TOARS.
    10.1524/ract.2007.95.6.335
  90. Campello, M.P.; Marques, F.; Gano, L.; Lacerda, S.; Santos, I.. "Radiochemical and biological behaviour of 153Sm and 166Ho complexes anchored by a novel bis(methylphosphonate) tetraazamacrocycle". Radiochimica Acta 95 6 (2007): 329-334. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250782134&partnerID=MN8TOARS.
    10.1524/ract.2007.95.6.329
  91. Fernandes, C.; Oliveira, C.; Gano, L.; Bourkoula, A.; Pirmettis, I.; Santos, I.. "Radioiodination of new EGFR inhibitors as potential SPECT agents for molecular imaging of breast cancer". Bioorganic and Medicinal Chemistry 15 12 (2007): 3974-3980. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247846160&partnerID=MN8TOARS.
    10.1016/j.bmc.2007.04.008
  92. Palma, E.; Oliveira, B.L.; Correia, J.D.G.; Gano, L.; Maria, L.; Santos, I.C.; Santos, I.. "A new bisphosphonate-containing 99mTc(I) tricarbonyl complex potentially useful as bone-seeking agent: Synthesis and biological evaluation". Journal of Biological Inorganic Chemistry 12 5 (2007): 667-679. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249871641&partnerID=MN8TOARS.
    10.1007/s00775-007-0215-0
  93. Gano, L.; Marques, F.; Campbello, M.P.; Balbina, M.; Lacerda, S.; Santos, I.. "Radiolanthanide complexes with tetraazamacrocycles bearing methylphosphonate pendant arms as bone seeking agents". Quarterly Journal of Nuclear Medicine and Molecular Imaging 51 1 (2007): 6-15. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249731389&partnerID=MN8TOARS.
  94. Alves, S.; Correia, J.D.G.; Gano, L.; Rold, T.L.; Prasanphanich, A.; Haubner, R.; Rupprich, M.; et al. "In vitro and in vivo evaluation of a novel 99mTc(CO) 3-pyrazolyl conjugate of cyclo-(Arg-Gly-Asp-D-Tyr-Lys)". Bioconjugate Chemistry 18 2 (2007): 530-537. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947693768&partnerID=MN8TOARS.
    10.1021/bc060234t
  95. Videira, M.A.; Gano, L.; Santos, C.; Neves, M.; Almeida, A.J.. "Lymphatic uptake of lipid nanoparticles following endotracheal administration". Journal of Microencapsulation 23 8 (2006): 855-862. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847372015&partnerID=MN8TOARS.
    10.1080/02652040600788221
  96. Garcia, R.; Gano, L.; Maria, L.; Paulo, A.; Santos, I.; Spies, H.. "Synthesis and biological evaluation of tricarbonyl Re(I) and Tc(I) complexes anchored by poly(azolyl)borates: Application on the design of radiopharmaceuticals for the targeting of 5-HT1A receptors". Journal of Biological Inorganic Chemistry 11 6 (2006): 769-782. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746266862&partnerID=MN8TOARS.
    10.1007/s00775-006-0124-7
  97. Oliveira, M.C.; Videira, M.; Almeida, A.; Gano, L.; Watanabe, M.; Thiemann, T.; Santos, A.C.; Botelho, F.; Oliveira, C.. "Synthesis and biodistribution studies of two novel radioiodinated areno-annelated estra-1,3,5(10), 16-tetraene-3-ols as promising estrogen receptor radioligands". Journal of Labelled Compounds and Radiopharmaceuticals 49 6 (2006): 559-569. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745609761&partnerID=MN8TOARS.
    10.1002/jlcr.1076
  98. Marques, F.; Gano, L.; Paula Campello, M.; Lacerda, S.; Santos, I.; Lima, L.M.P.; Costa, J.; Antunes, P.; Delgado, R.. "13- and 14-membered macrocyclic ligands containing methylcarboxylate or methylphosphonate pendant arms: Chemical and biological evaluation of their 153Sm and 166Ho complexes as potential agents for therapy or bone pain palliation". Journal of Inorganic Biochemistry 100 2 (2006): 270-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-30544449145&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2005.11.011
  99. Marques, F.; Paulo, A.; Campello, M.P.; Lacerda, S.; Vitor, R.F.; Gano, L.; Delgado, R.; Santos, I.. "Radiopharmaceuticals for targeted radiotherapy". Radiation Protection Dosimetry 116 1-4 (2005): 601-604. http://www.scopus.com/inward/record.url?eid=2-s2.0-31544473459&partnerID=MN8TOARS.
    10.1093/rpd/nci251
  100. Santos, M.A.; Gama, S.; Gano, L.; Farkas, E.. "Bis(3-hydroxy-4-pyridinone)-EDTA derivative as a potential therapeutic Al-chelating agent. Synthesis, solution studies and biological assays". Journal of Inorganic Biochemistry 99 9 SPEC. IS (2005): 1845-1852. http://www.scopus.com/inward/record.url?eid=2-s2.0-24344487413&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2005.06.022
  101. Santos, M.A.; Gil, M.; Gano, L.; Chaves, S.. "Bifunctional 3-hydroxy-4-pyridinone derivatives as potential pharmaceuticals: Synthesis, complexation with Fe(III), Al(III) and Ga(III) and in vivo evaluation with 67Ga". Journal of Biological Inorganic Chemistry 10 5 (2005): 564-580. http://www.scopus.com/inward/record.url?eid=2-s2.0-25844528047&partnerID=MN8TOARS.
    10.1007/s00775-005-0003-7
  102. Fernandes, C.; Correia, J.D.G.; Gano, L.; Santos, I.; Seifert, S.; Syhre, R.; Bergmann, R.; Spies, H.. "Dramatic effect of the tridentate ligand on the stability of 99mTc "3 + 1" oxo complexes bearing arylpiperazine derivatives". Bioconjugate Chemistry 16 3 (2005): 660-668. http://www.scopus.com/inward/record.url?eid=2-s2.0-18844423026&partnerID=MN8TOARS.
    10.1021/bc049718k
  103. Alves, S.; Paulo, A.; Correia, J.D.G.; Gano, L.; Smith, C.J.; Hoffman, T.J.; Santos, I.. "Pyrazolyl derivatives as bifunctional chelators for labeling tumor-seeking peptides with the fac-[M(CO)3]+ moiety (M = 99mTc, Re): Synthesis, characterization, and biological behavior". Bioconjugate Chemistry 16 2 (2005): 438-449. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244347266&partnerID=MN8TOARS.
    10.1021/bc0497968
  104. Santos, M.A.; Gil, M.; Marques, S.; Gano, L.; Chaves, S.. "N-Arylamine derivatives of 3-hydroxy-4-pyridinones: Solution studies and bioevaluation in view of Al-detoxification roles". Analytical and Bioanalytical Chemistry 381 2 (2005): 413-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844257059&partnerID=MN8TOARS.
    10.1007/s00216-004-2823-7
  105. Santos, M.A.; Gama, S.; Gano, L.; Cantinho, G.; Farkas, E.. "A new bis(3-hydroxy-4-pyridinone)-IDA derivative as a potential therapeutic chelating agent. Synthesis, metal-complexation and biological assays". Dalton Transactions 21 (2004): 3772-3781. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644260383&partnerID=MN8TOARS.
    10.1039/b409357g
  106. Marques, F.; Guerra, K.P.; Gano, L.; Costa, J.; Campello, M.P.; Lima, L.M.P.; Delgado, R.; Santos, I.. "153Sm and 166Ho complexes with tetraaza macrocycles containing pyridine and methylcarboxylate or methylphosphonate pendant arms". Journal of Biological Inorganic Chemistry 9 7 (2004): 859-872. http://www.scopus.com/inward/record.url?eid=2-s2.0-8644263006&partnerID=MN8TOARS.
    10.1007/s00775-004-0587-3
  107. Fernandes, C.; Kniess, T.; Gano, L.; Seifert, S.; Spies, H.; Santos, I.. "Synthesis and biological evaluation of silylated mixed-ligand 99mTc complexes with the [PNS/S] donor atom set". Nuclear Medicine and Biology 31 6 (2004): 785-793. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042836911&partnerID=MN8TOARS.
    10.1016/j.nucmedbio.2004.03.011
  108. Chaves, S.I.; Gil, M.; Marques, S.E.; Gano, L.; Santos, M.A.. "Alkylaryl-amino derivatives of 3-hydroxy-4-pyridinones as aluminium chelating agents with potential clinical application". Journal of Inorganic Biochemistry 97 1 (2003): 161-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141851353&partnerID=MN8TOARS.
    10.1016/S0162-0134(03)00238-1
  109. Neves, M.; Gano, L.; Pereira, N.; Costa, M.C.; Costa, M.R.; Chandia, M.; Rosado, M.; Fausto, R.. "Synthesis, characterization and biodistribution of bisphosphonates Sm-153 complexes: Correlation with molecular modeling interaction studies". Nuclear Medicine and Biology 29 3 (2002): 329-338. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036203472&partnerID=MN8TOARS.
    10.1016/S0969-8051(01)00305-5
  110. Santos, M.A.; Gil, M.; Marques, S.; Gano, L.; Cantinho, G.; Chaves, S.. "N-Carboxyalkyl derivatives of 3-hydroxy-4-pyridinones: Synthesis, complexation with Fe(III), Al(III) and Ga(III) and in vivo evaluation". Journal of Inorganic Biochemistry 92 1 (2002): 43-54. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037201554&partnerID=MN8TOARS.
    10.1016/S0162-0134(02)00483-X
  111. Melo e Silva, M.Cristina; Patrício, L.; Gano, L.; Sá e Melo, M.Luísa; Inohae, E.; Mataka, S.; Thiemann, T.. "Synthesis and biological evaluation of two new radiolabelled estrogens: [125I](E)-3-methoxy-17a-iodovinylestra-1,3,5(10),6-tetraen-17ß-ol and [125I](Z)-3-methoxy-17a-iodovinylestra-1,3,5(10),6-tetraen-17ß-ol". Applied Radiation and Isotopes 54 2 (2001): 227-239. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035255412&partnerID=MN8TOARS.
    10.1016/S0969-8043(99)00258-4
  112. Santos, M.A.; Grazina, R.; Neto, A.Q.; Cantinho, G.; Gano, L.; Patrício, L.. "Synthesis, chelating properties towards gallium and biological evaluation of two N-substituted 3-hydroxy-4-pyridinones". Journal of Inorganic Biochemistry 78 4 (2000): 303-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034737803&partnerID=MN8TOARS.
    10.1016/S0162-0134(00)00058-1
  113. Neves, M.; Gano, L.; Ribeiro, M.J.; Santos, A.C.; Marchi, A.; Sawas-Dimopolou, C.; Pedroso De Lima, J.J.. "Synthesis, characterization, and biodistribution of oxo complexes of technetium-99m with biguanide and N1-substituted ligands". Nuclear Medicine and Biology 26 1 (1999): 79-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032945206&partnerID=MN8TOARS.
    10.1016/S0969-8051(98)00074-2
  114. Gano, L.; Patrício, L.; Marques, E.; Cantinho, G.; Pena, H.; Martins, T.; Hnatowich, D.J.. "Human polyclonal immunoglobulin labelled with technetium-99m via NHS- MAG3: A comparison of radiochemical behavior and biological efficacy with other labelling methods". Nuclear Medicine and Biology 25 4 (1998): 395-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345267055&partnerID=MN8TOARS.
    10.1016/S0969-8051(97)00225-4
  115. Gano, L.; Fernandes, C.; Cantinho, G.; Santos, A.I.; Pena, H.; Vieira, R.; Salgado, L.; Patrício, L.. "Technetium-99m labelling of the IOR CEA 1 monoclonal antibody: Evaluation of different methods | 99mTc-markierung des monoklonalen antikorpers IOR CEA 1: Bewertung unterschiedlicher methoden". NuklearMedizin 36 6 (1997): 205-212. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030612103&partnerID=MN8TOARS.
  116. Gano, L.; Rodrigues, A.; Marques, E.; Patricio, L.. "Comparison of the radiochemical behaviour and biological efficacy of three 99mTc-HIG preparations". Journal of Nuclear Biology and Medicine 38 4 SUPPL. 1 (1994): 38-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028672924&partnerID=MN8TOARS.
  117. Gano, L.; Patricio, L.; Castanheira, I.. "Radiopharmaceuticals for renal studies: Evaluation of protein binding". Journal of Radioanalytical and Nuclear Chemistry Articles 132 1 (1989): 171-178. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024335073&partnerID=MN8TOARS.
    10.1007/BF02060989
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/09/17 Bioorthogonal Chemistry Approach for Theranostics of GRPR-expressing Cancers TERACHEM 2022
(Bressanone, Italy)
2022/09 Image-Guided Nanodelivery of Pt(IV) Prodrugs for Gastrin-Releasing Peptide Receptors in prostate PC3 cells The 6th Cancer World Congress
2022/03 Within the framework of the divulgation of results has co-authored more than 50 oral communications, 26 of them as presenter or student supervisor, in international meetings.
2018/05 Clickable radioimmunoconjugates: Theranostic agents for TEM1 pre-targeting A. D’Onofrio, L. Gano, F. Mendes, C. Oliveira, D. Thibaut, D. Viertl, s. Dunn, J. Fierle, J. Prior; A. Paulo, MEDICIS Promed Final Conference
(Italy)
2018/04 Biological Assessment of a Radiolabelled LXXLL-Peptide for Breast Cancer Theranostics
19th European Symposium on Radiopharmacy and Radiopharmaceuticals (Groninghen, Netherlands)
2018/03 Multifunctional agent for breast cancer radiotheranostics
Fourth International Conference on Precision Image-Guided Small Animal Radiotherapy Research (Bobadela, Portugal)
2018/03 Multifunctional bioconjugated gold nanoparticles for cancer theranostics Fourth International Conference on Precision Image-Guided Small Animal Radiotherapy Research
(Bobadela, Portugal)
2017/09 Radiopharmacy – Radiobiological concerns regarding radiopharmaceutical applications Conferência Proteção Radiológica na Saúde 2017
(Lisboa, Portugal)
2016/02 In-111 labeled peptides towards the estrogen receptor for theranostic of breast cancer 15th Iberian Peptide Meeting
(Porto, Portugal)
2016/02 A novel peptide platform derived from Dengue virus for drug delivery into the brain 15th Iberian Peptide Meeting
(Porto, Portugal)
2016/02 Novel radiopeptides for molecular imaging of EGFR positive tumors 15th Iberian Peptide Meeting
(Porto, Portugal)
2015/11 Microscopic analysis of the antitumor effects of ruthenium complexes in a prostate cancer model 1st International Congress CiiEM: From Basic Sciences to Clinical Research
(Costa da Caparica, Portugal)
2015/09 Biological assessment of radiolabelled gold nanoparticles for in vivo Targeting of GRPr expressing tumours. New Advances in Animal Models and Preclinical Imaging for Translational Research in Cancerology
(La Point de Pen Bron, Nantes, France)
2015/09 Bisphosphonate-containing 99mTc(I)/188Re(I) organometallic complexes for theranostic applications COST TD1004, Annual Meeting
(Belgrade, Serbia)
2015/04 Influence of the radionuclide on the stability and biological profile of an ER targeting peptide Workshop LOWDOSE-PT- 2015, Biological effects and risks of low dose and protracted exposures to ionizing radiation
(Bobadela, Portugal)
2015/04 Radiotoxic and genotoxic effects of 188Re multi-functional bone-seeking agents Workshop LOWDOSE-PT- 2015, Biological effects and risks of low dose and protracted exposures to ionizing radiation
(Bobadela, Portugal)
2014/04 Novel 111In-estradiol based complexes for oestrogen receptor targeting 17th European Symposium on Radiopharmacy and Radiopharmaceuticals (ESRR’14)
(Pamplona, Spain)
2013/11 Small core gold nanoparticles stabilized by thiolated DOTA derivatives Nanoparticles for early Diagnostics of inflammatory diseases
(Lisboa, Portugal)
2013/09 Indium-111 radiolabelled peptide towards the estrogen receptor. The Future of radiation oncology: Imaging, Dosimetry, Biology & Therapy The Future of radiation oncology: Imaging, Dosimetry, Biology & Therapy - Seventh Berder Workshop
(Ile de Berder, France)
2013/09 Perfusion and specific radioprobes for cardiac imaging 1st International Congress on Cardiovascular Technologies – CARDIOTECHNIX 2013
(Vilamoura, Portugal)
2013/09 Mitochondria-targeted Re(I)/99mTc(I) tricarbonyl complexes WG3 meeting – COST CM1105
(Barcelona, Spain)
2013/07 Pharmacokinetic properties of a 67Ga-labeled anti-TNF VHH single domain antibody containing a bacterial albumin-binding domain (Zag) 2nd International Workshop on Innovative Personalized Radioimmunotherapy, WIPR 2013
(Nantes, France)
2013/06 A bifunctional tripodal hydroxypyrimidinone-based chelator for metal decorporation XXIV International Symposium on Metal Complexes, ISMEC 2013
(Burgos, Spain)
2010/05 Biological evaluation of novel 99mTc(I) cationic complexes as probes for tumoral detection 16th European Symposium on Radiopharmacy and Radiopharmaceuticals (ESRR’10)
(Edinburgh, United Kingdom)
2006 Radiolanthanide complexes with tetraazamacrocycles bearing methylphosphonate pendant arms as bone seeking agents 13th European Symposium on Radiopharmacy and Radiopharmaceuticals
(Lucca, Italy)
2006 Mixed tetraazamacrocycles with phosphonate pendant arms: The influence of the number of phosphonate arms on the radiochemical and biological behaviour of their 153Sm and 166Ho complexes 7th International Symposium on Technetium in Chemistry and Nuclear Medicine
(Bressanone, Italy)
2004 Peptide derivatives of 3-hydroxy-4-pyridinone with potential medicinal application 9th Iberian Peptide Meeting
(Porto, Portugal)
2004 99mTc Mixed-ligand complexes with heterofunctionalized phosphines with high affinity for 5-HT1A receptor 12th European Symposium on Radiopharmacy and Radiopharmaceuticals
(Gdansk, Poland)
2003 In Vitro and in vivo evaluation of 153Sm and 166Ho complexes with macrocycles 11th European Symposium on Radiopharmacy and Radiopharmaceuticals
(Innsbruck, Austria)
2002 New building blocks containing an unprecedented B-H…M (M = Re, Tc) agostic interaction for the labelling of CNS-receptor ligands Conference on Advances and Perspectives in Radiotracer Development
(Dresden, Germany)
2002 Molecular modelling and radiopharmaceutical design World Congress of Nuclear Medicine
(Santiago, Chile)
2000 Ensino e Actividades de I&D em Radiofarmácia Congresso Ibero-Americano de Medicina Nuclear. VIII SPMN-XVII ALASBIMN
(Porto, Portugal)
2000 Síntese, caracterização e biodistribuição de 153Sm-Bisfosfonatos XVII ALASBIMN Congress of Nuclear Medicine and VIII SPMN
(Porto, Portugal)
1999 99mTc-Octreotide – A biological evaluation 9th European Symposium on Radiopharmacy and Radiopharmaceuticals
(Lillehammer, Norway)
1998 Ciprofloxacin in imaging of infective versus sterile inflammation International Symposium on Modern Trends in Radiopharmaceuticals for Diagnosis and Therapy
(Lisboa, Portugal)
1997 Tc-99m-Human polyclonal immunoglobulin via NHS-MAG3: Comparison of radiochemical behaviour and biological efficacy with other Tc-99m-Immunoglobulin 7th European Symposium on Radiopharmacy and Radiopharmaceuticals
(Maastricht, Netherlands)
1992 Radiolabelling of HIG with 99mTc-comparison of two different techniques European Association of Nuclear Medicine Congress
(Lisboa, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2014 - 2018/05 111In-labelled peptides for breast cancer theranostics
Supervisor
Chemistry (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2016 Determinação da captação de iodo por células tumorais da tiroide por µ-AMS e deteção gama
Supervisor
Tecnologias Biomédicas (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2011 - 2015/05 Avaliação do potencial clínico de novos ligandos para o receptor estrogénico em diagnóstico e terapia de tumores da mama
Supervisor
Chemistry (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013/02 - 2013/07 Utilização de antagonistas da bombesina em medicina Nuclear
Supervisor
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2013/02 - 2013/06 Radioimunoterapia em linfomas não-Hodgkin
Supervisor
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2011 - 2013 Síntese e avaliação pré-clínica de complexos de índio derivados do estradiol para radioterapia tumoral
Supervisor
2012/02 - 2012/07 RGD na monitorização e terapêutica de angiogénese associada a processos patológicos
Supervisor
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2012/02 - 2012/07 A utilização da tomografia por emissão de positrão na doença de Alzheimer
Supervisor
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2011/10 - 2012/02 Marcação da grelina - potencial interesse da sua aplicação em Medicina Nuclear
Supervisor
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2010/02 - 2010/07 Metabolização de radiofármacos ao nìvel do citocromo P450
Supervisor
2010/02 - 2010/06 Modelos animais em imagem préclínica
Supervisor
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2009/02 - 2009/06 Ensaios Biológicos In Vitro e In Vivo para Avaliação do Interesse de Novos Compostos Radioactivos como Radiofármacos
Supervisor
2008 - 2009 Desenvolvimento de radiofármaco para estudo não invasivo do trânsito intestinal
Supervisor
Química Inorgânica Biomédica: Aplicações em Diagnóstico e Terapia (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2007 - 2008 Avaliação Biológica de Complexos Catiónicos de 99mTc(I) para detecção tumoral
Supervisor
Química Inorgânica Biomédica: Aplicações em Diagnóstico e Terapia (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2005/10 - 2006/06 Marcação de Leucócitos com Complexos Contendo a Unidade fac-99mTc(CO)3
Supervisor
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2004/10 - 2005/05 Marcação de Eritropoietina com Tc-99m e sua avaliação in vitro/in vivo
Supervisor
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2023/03/06 Estudos préclinicos em murganhos para avaliar o potencial de um metalofármaco de ruténio num modelo de cancro colorretal
(Thesis) Main arguer
Ana Teresa da Silva Lopes (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2020/10/08 New Molecular Imaging Tools for Cystic Fibrosis
Thesis Member
Vera Filipa Cerqueira Ferreira (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/09 Clickable Radiocomplexes for Cancer Theranostics
Thesis Member
Alice D'Onofrio (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/05/28 111In-labelled peptides for breast cancer theranostics
Supervisor
Filipe André Jardim dos Vultos (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/11/14 Nuclear and Fluorescence Imaging using Single Domain Antibodies as Biomarkers for Alzheimer’s Disease
(Thesis) Main arguer
Pedro David Pereira Mendes Fontes (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/03/08 A Radioterapia Metabólica no Tratamento do Adenocarcinoma Pancreático
(Thesis) Main arguer
Rui Vasco Quintais Gradiz (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/05 Avaliação do Potencial Clínico de Novos Ligandos para o Receptor Estrogénico em Diagnóstico e Terapia de Tumores da Mama
Supervisor
Susana Manuela Pereira da Cunha (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015/04 99mTc-PEI-MP and 188Re-PEI-MP for Imaging and Therapy of the Bladder Malignant Tumours - An Experimental Study
(Thesis) Main arguer
Sara Margarida Araújo Ferreira (PhD)
Universidade do Minho Escola de Ciências, Portugal
2014/12 Fotossensibilizadores para Terapia e Imagem em Oncologia
(Thesis) Main arguer
Mafalda Sofia Laranjo Cândido (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/11 Gallium Compounds for the design of (Nano)radiopharmaceuticals
Thesis Member
Francisco França A.C. Silva (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014/11 Biological Assessment for Micro-AMS Thyroid Cancer Cells using Iodine-125
(Thesis) Main arguer
Daniel José Gonçalves Bidarra (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/07 Nova Abordagem TeraPêutica para o Colangiocarcinoma – do NIS à Radioterapia Metabólica
(Thesis) Main arguer
Ana Cláudia Batista Jordão Ribeiro (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2012/02 Efeitos da Radiação X e Níveis de Exposição em Exames Imagiológicos
(Thesis) Main arguer
Patrícia Carvalho Veludo (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2011/12 Espectros Obtidos por Método HPLC após Marcação de Peptídeos com Gálio-68: Influência do Tipo de Gerador Utilizado
(Thesis) Main arguer
Abigail dos Santos Moreira (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2011/10 Gallium Complexos Organometálicos de Re e Tc com Propriedades Osteotrópicas para Imagiologia e/ou Terapia
Thesis Member
Elisa Vaz Morgado de Palma (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011/10 Marcação de Anexina V para Imagem Funcional da Apoptose Celular
(Thesis) Main arguer
Susana Catarina Monteiro Valente (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010/12 Vitamina C, Cancro e Citotoxicidade Selectiva,
(Thesis) Main arguer
Ana Catarina Manjolinha Mamede (Master)
Universidade da Beira Interior, Portugal
2009/12 Desenvolvimento de Radiofármaco para Estudo Não Invasivo do Trânsito Intestina
Supervisor
Filipa Maria Costa Coutinho Lucena (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009/11 Avaliação Biológica de Complexos Catiónicos de 99mTc(I) para Detecção Tumoral
Supervisor
Susana Manuela Pereira da Cunha (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2008/08 Citotoxicidade da Vitamina C em Células Tumorais – Estudos in-vitro e in-vivo através de Métodos Bioquímicos e de Imagiologia Nuclear
(Thesis) Main arguer
Ana Salomé dos Santos Pires (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008/02 Agentes Quelantes com Potencial Aplicação Farmacológica – Polidenticidade e Bifuncionalidade
Thesis Member
Ana Sofia Cavalheiro Gama (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2007/11 Avaliação da Hipoxia Tumoral em Adenocarcinoma Colo-rectal
(Thesis) Main arguer
Ana Margarida Coelho Abrantes (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2003/10 99mTc(V)-Ácido Dimercaptosuccínico – Estudos In vitro e In vivo
(Thesis) Main arguer
Jorge Manuel Pereira Veiga (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal