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Joana Beatriz Sousa (December, 1979, Portugal) completed the PhD in Pharmaceutical Sciences -Specialty of Pharmacology and Pharmacotherapy (2014) by the University of Porto-Faculty of Pharmacy, MSc in Quality Control (2009) by the University of Porto-Faculty of Pharmacy and the degree in Biochemistry (2005) by the University of Coimbra-Faculty of Sciences and Technology. Joana Beatriz Sousa is currently a Guest Assistant Professor at the Department of Drug Sciences of the University of Porto (Portugal) and integrated researcher at REQUIMTE - LAQV, Porto. She has collaborated several national and international research projects and, until now, supervised a master's degree, in the pharmacology field. She has authored 26 scientific papers, 7 book chapters (H-index=11, ca. 275 citations) and has co-organized 2 scientific international events. She has been involved as a researcher in 6 projects. Joana Beatriz Sousa has a FELASA C certificate and accreditation by Direção Geral de Alimentação e Veterinária (DGAV, Portugal) to work with laboratory animals, including animal models of diseases. Her present research interests are medical biotechnology research with cell, tissue and organ-based assays and has focused on Drugs, Food and Health: Impact of Drugs and Foods on proteins/enzymes and receptors and their benefit in Physiology and Pathophysiology, namely in Hypertension and Fetal Programming, Endothelial Dysfunction, Inflammation, Oxidative Stress and Cancer. She has dedicated her work studying cell signalling pathways in animal tissues and in cell culture models (primary and immortalized): image analysis with immunohistochemistry (Laser Scanning Confocal Microscopy and alphascreen methodology) associated with qPCR and Western-blot. At the present she is co-supervisor of a PhD student developing assays with BSG and BSY brewing by-products which have given several stimulating results. Other courses considered relevant in hers academic/professional path: - Seminar “Fetal and perinatal programming of cardiovascular disease”, January 2013, FFUP, Porto. - Seminar on “Quantitative Image Analysis and Characterization of Material Microstructures”, December 2012, CEMUP, Porto. - Course in Confocal Spectral Microscopy Leica TCS, January 2013, Laboratory of Confocal Microscopy, SidI, UAM, Spain. - Workshop “Carl Zeiss Confocal Microscopy – LSM 700”, July 2010, IBMC, Porto. - Course “Statistical analysis of data using SPSS and MS Excell”, June/July 2010, FFUP, Porto. - Course “Workshop in Pharmacology”, May/June 2010, FFUP, Porto. The most frequent terms in the context of her scientific outputs are: vascular tissue, vascular cells, cell culture, in vivo, oxidative stress, noradrenaline, adenosine, adenosine receptors, GPCR, image analysis, oncology, fetal programming, metal-based chemotherapeutic drugs.
Identification

Personal identification

Full name
Joana Beatriz Alves da Silva Pinheiro de Sousa Terroso

Citation names

  • Sousa, Joana Beatriz

Author identifiers

Ciência ID
C319-7011-977F
ORCID iD
0000-0002-1744-7840

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Spanish; Castilian Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2014
Concluded
Doutoramento em Ciências Farmacêuticas-Especialização em Farmacologia e Farmacoterapia (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
"Adenosine receptors in vascular sympathetic neurotransmission: the role of endothelium and of nitric oxide-mediated effects and their relation with hypertension" (THESIS/DISSERTATION)
Aprovado com distinção por unanimidade
2009
Concluded
Mestrado em Controlo de Qualidade (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"“Derivados do Ácido Cafeico – Efeito Antioxidante e Anti-inflamatório”" (THESIS/DISSERTATION)
Muito Bom
2005
Concluded
Bioquimica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Estudo de Compostos Potencialmente Anticancerígenos por Espectroscopia de Raman, Métodos Teóricos e Determinação de Citotoxicidade" (THESIS/DISSERTATION)
licenciatura - 13, Estágio Científico - 19
Affiliation

Teaching in Higher Education

Category
Host institution
Employer
2013/02/01 - Current Invited Assistant (University Teacher) Universidade do Porto, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal

Others

Category
Host institution
Employer
2016/08/01 - Current Docente como assistente convidada da disciplina Fisiologia Humana do Mestrado Integrado em Ciências Farmacêuticas. Universidade do Porto Faculdade de Farmácia, Portugal
2014/01/01 - Current Trabalhos de investigação relativos à Inervação simpática em vasos de ratos normotensos e espontaneamente hipertensos por microscopia de confocal, no âmbito da colaboração existente entre a Faculdade Universidade do Porto Faculdade de Farmácia, Portugal
2013/02/01 - Current Docente como assistente convidada da disciplina Anatomia-Histologia do Mestrado Integrado em Ciências Farmacêuticas. Universidade do Porto Faculdade de Farmácia, Portugal
2014/11/15 - 2014/12/15 Desenvolvimento dos trabalhos relativos ao projeto vencedor do concurso "Programa Bolsas Iberoamericanas para Jovens Professores e Investigadores Santander Universidades – 2014-2015". Universidad Autónoma de Madrid Facultad de Medicina, Spain
2010/05/01 - 2014/04/30 Bolsa de Doutoramento com a referência SFRH / BD / 63420 / 2009, “Role of adenosine receptors in vascular responsiveness: influence of ROS levels and NO-mediated effects, and its relation with hyperte Universidade do Porto Faculdade de Farmácia, Portugal
2012/09/10 - 2012/09/21 14th edition of the IBMC Laboratory Animal Science Course with international accreditation scheme run by FELASA (Federation of European Laboratory Animal Science Associations). Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2009/10/01 - 2010/04/30 Bolsa de investigação Científica IMM/BI/51-2009 inserida no projecto PTDC/SAL-FCF/69493/2006 intitulado “Levando analgésicos derivados da Quiotorfina ao encéfalo” no Instituto de Histologia e Embriolo Instituto de Medicina Molecular, Portugal
2009/09/08 - 2009/09/10 Participação na comissão organizadora do "VI Congresso Ibérico de Espectroscopia". 8 a 10 de Setembro, Porto, Portugal. 2009. Universidade do Porto Faculdade de Farmácia, Portugal
2008/01/01 - 2008/06/30 Bolsa de investigação Científica inserida no projecto POCI/SAU-FCF/60782/2004 “Papel protector da adenosina na inflamação vascular: mecanismos moleculares e implicações clínicas”. Universidade do Porto Faculdade de Farmácia, Portugal
2007/04/28 - 2007/05/01 Participação na comissão organizadora do "First Iberic Meeting on Medicinal Chemistry: Anticancer Agents". 28 de Abril a 1 de Maio de 2007, Régua, Douro, Portugal. Universidade do Porto Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2009/09/01 - 2010/04/30 Levando analgésicos derivados da Quiotorfina ao encéfalo
PTDC/SAU-FCF/69493/2006
Research Fellow
Universidade do Porto Faculdade de Medicina, Portugal

Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/02/01 - 2008/07/31 Papel protector da adenosina na inflamação vascular: mecanismos moleculares e implicações clínicas
POCI/SAU-FCF/60782/2004
Scientific Initiation Fellow
Universidade do Porto Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2018/06/30 - Current New Marine Plant Food Ingredients
PTDC/BAA-AGR/29305/2017
Researcher
Ongoing
2011/01/01 - 2012/12/31 Characterization of adenosine receptors in mesenteric artery and their putative role in hypertension
E-73/2010
Researcher
Concluded
Outputs

Publications

Book chapter
  1. Sousa, Joana; Diniz, Carmen. "Vascular Sympathetic Neurotransmission and Endothelial Dysfunction". In Endothelial Dysfunction - Old Concepts and New Challenges. InTech, 2018.
    Published • 10.5772/intechopen.72442
  2. Sousa, Joana Beatriz. "Imaging receptors with Laser Scanning Confocal Microscopy: qualitative and quantitative analysis". In Microscopy: advances in scientific research and education. FORMATEX, 2014.
    Published
  3. Sousa, J.B.; Soares, A.S.; Fresco, P.; Diniz, C.. "Adenosine receptors in the vasculature: Physiology, pharmacology and therapeutic perspectives". 37-75. 2014.
  4. Soares, A.S.; Sousa, J.B.; Diniz, C.; Fresco, P.. "Insights on the role of adenosine and adenosine receptors on melanoma: New therapeutic strategies". 77-114. 2014.
  5. Leito-Rocha, Ana; Beatriz, Joana; Diniz, Carmen. "Adenosinergic System in the Mesenteric Vessels". In The Cardiovascular System - Physiology, Diagnostics and Clinical Implications. InTech, 2012.
    Published • 10.5772/38534
Conference paper
  1. Sousa, Joana Beatriz. "Endothelial nitric oxide modulatory role on vascular sympathetic reactivity". Paper presented in 6th European Congress of Pharmacology, Granada, 2013.
    Published
Journal article
  1. Ribeiro-Oliveira, Rita; Rodríguez-Rodríguez, Pilar; Sousa, Joana Beatriz; Ferreira, Isabel M.P.L.V.O.; Arribas, Silvia M.; Diniz, Carmen. "Managing hypertension using brewing bioactive peptides as angiotensin-converting enzyme inhibitors: Impact on vascular tone through ex vivo assays". PharmaNutrition 28 (2024): 100389. http://dx.doi.org/10.1016/j.phanu.2024.100389.
    Published • 10.1016/j.phanu.2024.100389
  2. Rita Ribeiro-Oliveira; Zita E. Martins; Miguel Ângelo Faria; Joana Beatriz Sousa; Isabel M. P. L. V. O. Ferreira; Carmen Diniz. "Natural Brewing Peptides with Enhanced Inhibitory Effects on Angiotensin I-Converting Enzyme". ECMC 2022 (2022):
    Open access • 10.3390/ecmc2022-13426
  3. Rita Ribeiro-Oliveira; Zita E. Martins; Miguel Ângelo Faria; Joana Beatriz Sousa; Isabel M. P. L. V. O. Ferreira; Carmen Diniz. "Protein Hydrolysates from Brewing By-Products as Natural Alternatives to ACE-Inhibitory Drugs for Hypertension Management". Life 12 (2022): 1554.
    Open access • 10.3390/life12101554
  4. Ana Sofia Cerquido; Martin Vojtek; Rita Ribeiro-Oliveira; Salomé Gonçalves-Monteiro; Maria João Barroca; Aida Moreira da Silva; Olga Viegas; et al. "Corema album Leaves Mediate DNA Damage in Triple-Negative Breast Cancer Cells". Current Issues in Molecular Biology 44 (2022): 3598-3610.
    Open access • 10.3390/cimb44080246
  5. Maria Sofia Vieira-Rocha; Joana Beatriz Sousa; Pilar Rodríguez-Rodríguez; Silvia Madaglena Arribas; Carmen Diniz. "Elevated Vascular Sympathetic Neurotransmission and Remodelling Is a Common Feature in a Rat Model of Foetal Programming of Hypertension and SHR". Biomedicines 10 (2022): 1902.
    Open access • 10.3390/biomedicines10081902
  6. Maria Sofia Vieira-Rocha; Pilar Rodriguez-Rodriguez; Mariana Ferreira-Duarte; Miguel Faria; Joana Beatriz Sousa; Manuela Morato; Silvia Magdalena Arribas; Carmen Diniz. "Fetal Undernutrition Modifies Vascular RAS Balance Enhancing Oxidative Damage and Contributing to Remodeling". International Journal of Molecular Sciences 23 (2022): 1233.
    Open access • 10.3390/ijms23031233
  7. Rita Ribeiro-Oliveira; Zita E. Martins; Joana Beatriz Sousa; Isabel M.P.L.V.O. Ferreira; Carmen Diniz. "The health-promoting potential of peptides from brewing by-products: An up-to-date review". Trends in Food Science & Technology 118 (2021): 143-153. https://doi.org/10.1016/j.tifs.2021.09.019.
    10.1016/j.tifs.2021.09.019
  8. Salomé Gonçalves-Monteiro; Rita Ribeiro-Oliveira; Maria Sofia Vieira-Rocha; Martin Vojtek; Joana B. Sousa; Carmen Diniz. "Insights into Nuclear G-Protein-Coupled Receptors as Therapeutic Targets in Non-Communicable Diseases.". Pharmaceuticals 14 (2021): 439.
    Open access • 10.3390/ph14050439
  9. Ferreira-Duarte, Mariana; Sousa, Joana Beatriz; Diniz, Carmen; Sousa, Teresa; Duarte-Araújo, Margarida; Morato, Manuela. "Experimental and Clinical Evidence of Endothelial Dysfunction in Inflammatory Bowel Disease". Current Pharmaceutical Design 26 30 (2020): 3733-3747. http://dx.doi.org/10.2174/1381612826666200701212414.
    Published • 10.2174/1381612826666200701212414
  10. Vieira-Rocha, Maria S.; Sousa, Joana B.; Rodriguez-Rodriguez, Pilar; Morato, Manuela; Arribas, Silvia M.; Diniz, Carmen. "Insights into sympathetic nervous system and GPCR interplay in fetal programming of hypertension: a bridge for new pharmacological strategies". Drug Discovery Today (2020): http://dx.doi.org/10.1016/j.drudis.2020.01.019.
    Published • 10.1016/j.drudis.2020.01.019
  11. Ribeiro-Oliveira, Rita; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Vieira-Rocha, Maria Sofia; Sousa, Joana B.; Gonçalves, Jorge; Diniz, Carmen. "Nuclear G-protein-coupled receptors as putative novel pharmacological targets". Drug Discovery Today 24 11 (2019): 2192-2201. http://dx.doi.org/10.1016/j.drudis.2019.09.003.
    Published • 10.1016/j.drudis.2019.09.003
  12. Vieira-Rocha, M.S.; Rodríguez-Rodríguez, P.; Sousa, J.B.; González, M.C.; Arribas, S.M.; López de Pablo, A.L.; Diniz, C.. "Vascular angiotensin AT1 receptor neuromodulation in fetal programming of hypertension". Vascular Pharmacology 117 (2019): 27-34. http://dx.doi.org/10.1016/j.vph.2018.10.003.
    Published • 10.1016/j.vph.2018.10.003
  13. Viegas, Olga; Faria, Miguel A.; Sousa, Joana B.; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Suliburska, Joanna; Diniz, Carmen; Ferreira, Isabel M.P.L.V.O.. "Delphinidin-3-O-glucoside inhibits angiogenesis via VEGFR2 downregulation and migration through actin disruption". Journal of Functional Foods 54 (2019): 393-402. http://dx.doi.org/10.1016/j.jff.2019.01.039.
    Published • 10.1016/j.jff.2019.01.039
  14. Sousa-Oliveira, Ana; Brandão, Ana; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Sousa, Joana B.; Diniz, Carmen. "Vascular impairment of adenosinergic system in hypertension: increased adenosine bioavailability and differential distribution of adenosine receptors and nucleoside transporters". Histochemistry and Cell Biology 151 5 (2018): 407-418. http://dx.doi.org/10.1007/s00418-018-1743-0.
    Published • 10.1007/s00418-018-1743-0
  15. Sousa, Joana B.; Fresco, Paula; Diniz, Carmen; Goncalves, Jorge. "Adenosine Receptor Ligands on Cancer Therapy: A Review of Patent Literature". Recent Patents on Anti-Cancer Drug Discovery 13 1 (2018): http://dx.doi.org/10.2174/1574892812666171108115959.
    10.2174/1574892812666171108115959
  16. Sousa, Joana; Diniz, Carmen. "The Adenosinergic System as a Therapeutic Target in the Vasculature: New Ligands and Challenges". Molecules 22 5 (2017): 752. http://dx.doi.org/10.3390/molecules22050752.
    Published • 10.3390/molecules22050752
  17. Batista de Carvalho, Ana L. M.; Medeiros, Paula S. C.; Costa, Francisco M.; Ribeiro, Vanessa P.; Sousa, Joana B.; Diniz, Carmen; Marques, Maria P. M.. "Anti-Invasive and Anti-Proliferative Synergism between Docetaxel and a Polynuclear Pd-Spermine Agent". PLOS ONE 11 11 (2016): e0167218. http://dx.doi.org/10.1371/journal.pone.0167218.
    Published • 10.1371/journal.pone.0167218
  18. Sousa, Joana Beatriz; Vieira-Rocha, Maria Sofia; Arribas, Silvia M.; González, Maria Carmen; Fresco, Paula; Diniz, Carmen. "Endothelial and Neuronal Nitric Oxide Activate Distinct Pathways on Sympathetic Neurotransmission in Rat Tail and Mesenteric Arteries". PLOS ONE 10 6 (2015): e0129224. http://dx.doi.org/10.1371/journal.pone.0129224.
    Published • 10.1371/journal.pone.0129224
  19. Sousa, Joana B.; Fresco, Paula; Diniz, Carmen. "Endothelial dysfunction impairs vascular neurotransmission in tail arteries". Neurochemistry International 80 (2015): 7-13. http://dx.doi.org/10.1016/j.neuint.2014.11.001.
    Published • 10.1016/j.neuint.2014.11.001
  20. Sousa, Joana Beatriz; Vieira-Rocha, Maria Sofia; Sá, Carlos; Ferreirinha, Fátima; Correia-de-Sá, Paulo; Fresco, Paula; Diniz, Carmen. "Lack of Endogenous Adenosine Tonus on Sympathetic Neurotransmission in Spontaneously Hypertensive Rat Mesenteric Artery". PLoS ONE 9 8 (2014): e105540. http://dx.doi.org/10.1371/journal.pone.0105540.
    Published • 10.1371/journal.pone.0105540
  21. Rocha-Pereira, C.; Sousa, J.B.; Vieira-Rocha, M.S.; Fresco, P.; Gonçalves, J.; Diniz, C.. "Differential inhibition of noradrenaline release mediated by inhibitory A1-adenosine receptors in the mesenteric vein and artery from normotensive and hypertensive rats". Neurochemistry International 62 4 (2013): 399-405. http://dx.doi.org/10.1016/j.neuint.2013.02.010.
    Published • 10.1016/j.neuint.2013.02.010
  22. Tavares, S.; Sousa, J.; Gonçalves, P.; Araújo, J.R.; Martel, F.. "The effect of folate status on the uptake of physiologically relevant compounds by Caco-2 cells". European Journal of Pharmacology 640 1-3 (2010): 29-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953811220&partnerID=MN8TOARS.
    10.1016/j.ejphar.2010.04.056
  23. Esteves, Mário; Siquet, Christophe; Gaspar, Alexandra; Rio, Vitor; Sousa, Joana B.; Reis, Salette; Marques, Maria P. M.; Borges, Fernanda. "Antioxidant Versus Cytotoxic Properties of Hydroxycinnamic Acid Derivatives – A New Paradigm in Phenolic Research". Archiv der Pharmazie 341 3 (2008): 164-173. http://dx.doi.org/10.1002/ardp.200700168.
    Published • 10.1002/ardp.200700168
  24. Chaves, Sílvia; Gil, Marco; Canário, Sónia; Jelic, Ratomir; Romão, Maria João; Trincão, José; Herdtweck, Eberhardt; et al. "Biologically relevant O,S-donor compounds. Synthesis, molybdenum complexation and xanthine oxidase inhibition". Dalton Transactions 13 (2008): 1773. http://dx.doi.org/10.1039/b717172b.
    Published • 10.1039/b717172b
  25. M. Marques, M. Paula; Borges, Fernanda; Sousa, Joana; Calheiros, Rita; Garrido, Jorge; Gaspar, Alexandra; Diniz, Carmen; Fresco, Paula. "Cytotoxic and COX-2 Inhibition Properties of Hydroxycinnamic Derivatives". Letters in Drug Design & Discovery 3 5 (2006): 316-320. http://dx.doi.org/10.2174/157018006777574212.
    Published • 10.2174/157018006777574212
  26. Sousa, J.B.; Calheiros, R.; Rio, V.; Borges, F.; Marques, M.P.M.. "Conformational analysis of the potential anticancer agent ethyl trihydroxycinnamate—A combined raman spectroscopy and ab initio study". Journal of Molecular Structure 783 1-3 (2006): 122-135. http://dx.doi.org/10.1016/j.molstruc.2005.09.004.
    Published • 10.1016/j.molstruc.2005.09.004
  27. Braga, Susana S.; Marques, Maria Paula M.; Sousa, Joana B.; Pillinger, Martyn; Teixeira-Dias, José J.C.; Gonçalves, Isabel S.. "Inclusion of molybdenocene dichloride (Cp2MoCl2) in 2-hydroxypropyl- and trimethyl-ß-cyclodextrin: Structural and biological properties". Journal of Organometallic Chemistry 690 12 (2005): 2905-2912. http://dx.doi.org/10.1016/j.jorganchem.2005.03.012.
    Published • 10.1016/j.jorganchem.2005.03.012
Report
  1. Ana Sofia Cerquido; Martin Vojtek; Rita Ribeiro-Oliveira; Olga Viegas; Joana Beatriz Sousa; Isabel M.P.L.V.O. Ferreira; Carmen Diniz. 2022. Unravelling potential health-beneficial properties of Corema album phenolic compounds: a systematic review. https://doi.org/10.37766/inplasy2022.8.0022.
    10.37766/inplasy2022.8.0022
Distinctions

Award

2014 "Programa Bolsas Iberoamericanas para Jovens Professores e Investigadores Santander Universidades – 2014-2015"
Universidade do Porto, Portugal