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Rosina Savisaar. Concluiu o(a) Doctor of Philosophy em Biology and Biochemistry em 2018/10/31 pelo(a) University of Bath Department of Biology and Biochemistry, Master em MSc in Neuroscience em 2013/09/12 pelo(a) University of Oxford e Licence em Sciences du Langage em 2012/06/12 pelo(a) Université de Lorraine UFR Sciences du langage.
Identification

Personal identification

Full name
Rosina Savisaar

Citation names

  • Savisaar, Rosina

Author identifiers

Ciência ID
C31A-EEE9-B628
ORCID iD
0000-0002-8367-2317

Email addresses

  • r.savisaar@medicina.ulisboa.pt (Professional)

Addresses

  • Instituto de Medicina Molecular, Avenida Professor Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Evolutionary Biology
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Estonian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Arab Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2)
Portuguese Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2018/10/31
Concluded
 Biology and Biochemistry (Doctor of Philosophy)
University of Bath Department of Biology and Biochemistry, United Kingdom
"The dual coding of RNA and protein level information within open reading frames" (THESIS/DISSERTATION)
 N/A
2013/09/12
Concluded
 MSc in Neuroscience (Master)
University of Oxford, United Kingdom
"1) Behavioural characterization of the A isoform of the fruitless gene in Drosophila. 2) Interneuron migration in the embryonic chick forebrain." (THESIS/DISSERTATION)
 N/A
2012/06/12
Concluded
 Sciences du Langage (Licence)
Université de Lorraine UFR Sciences du langage, France
"N/A" (THESIS/DISSERTATION)
 Très bien
Affiliation

Science

Category
Host institution 		Employer
2019/08/01 - Current Postdoc (Research) Instituto de Medicina Molecular, Portugal
2013/10/01 - 2014/08/31 Research Assistant (Research) Institut Jacques Monod, France
2011/08/01 - 2012/06/30 Research Assistant (Research) Analyse et Traitement Informatique de la Langue Française, France

Teaching in Higher Education

Category
Host institution 		Employer
2018/10/01 - 2019/07/31 Lecturer (University Teacher) Nile University, Egypt
Outputs

Publications

Book chapter
  1. Savisaar, Rosina. "The "Colorative Construction" in Estonian". In Meaning-text Theory: Current Developments, edited by Apresjan, Valentina. Sagner, 2013.
    Published
Journal article
  1. Custódio, Noélia; Savisaar, Rosina; Carvalho, Célia; Bak-Gordon, Pedro; Ribeiro, Maria I.; Tavares, Joana; Nunes, Paula B.; et al. "Expression Profiling in Ovarian Cancer Reveals Coordinated Regulation of BRCA1/2 and Homologous Recombination Genes". Biomedicines 10 2 (2022): 199. http://dx.doi.org/10.3390/biomedicines10020199.
    Published • 10.3390/biomedicines10020199
  2. Prudêncio, Pedro; Savisaar, Rosina; Rebelo, Kenny; Martinho, Rui Gonçalo; Carmo-Fonseca, Maria. "Transcription and splicing dynamics during early Drosophila development". RNA 28 2 (2021): 139-161. http://dx.doi.org/10.1261/rna.078933.121.
    Published • 10.1261/rna.078933.121
  3. Abrahams, Liam; Savisaar, Rosina; Mordstein, Christine; Young, Bethan; Kudla, Grzegorz; Hurst, Laurence D. "Evidence in disease and non-disease contexts that nonsense mutations cause altered splicing via motif disruption". Nucleic Acids Research 49 17 (2021): 9665-9685. http://dx.doi.org/10.1093/nar/gkab750.
    Published • 10.1093/nar/gkab750
  4. Mordstein, Christine; Savisaar, Rosina; Young, Robert S.; Bazile, Jeanne; Talmane, Lana; Luft, Juliet; Liss, Michael; et al. "Codon Usage and Splicing Jointly Influence mRNA Localization". Cell Systems (2020):
    Published • 10.1016/j.cels.2020.03.001
  5. Nagy, Olga; Nuez, Isabelle; Savisaar, Rosina; Peluffo, Alexandre E.; Yassin, Amir; Lang, Michael; Stern, David L.; et al. "Correlated Evolution of Two Copulatory Organs via a Single cis-Regulatory Nucleotide Change". Current Biology 28 21 (2018): 3450-3457.e13. http://dx.doi.org/10.1016/j.cub.2018.08.047.
    Published • 10.1016/j.cub.2018.08.047
  6. Savisaar, Rosina; Hurst, Laurence D.. "Exonic splice regulation imposes strong selection at synonymous sites". Genome Research 28 10 (2018): 1442-1454. http://dx.doi.org/10.1101/gr.233999.117.
    Open access • Published • 10.1101/gr.233999.117
  7. Savisaar, Rosina; Hurst, Laurence D.. "Estimating the prevalence of functional exonic splice regulatory information". Human Genetics 136 9 (2017): 1059-1078. http://dx.doi.org/10.1007/s00439-017-1798-3.
    Open access • Published • 10.1007/s00439-017-1798-3
  8. Casey, Ruth T.; Ascher, David B.; Rattenberry, Eleanor; Izatt, Louise; Andrews, Katrina A.; Simpson, Helen L.; Challis, Benjamen; et al. "SDHA related tumorigenesis: a new case series and literature review for variant interpretation and pathogenicity". Molecular Genetics & Genomic Medicine 5 3 (2017): 237-250. http://dx.doi.org/10.1002/mgg3.279.
    10.1002/mgg3.279
  9. Rosina, Savisaar; Hurst, Laurence D.. "Both maintenance and avoidance of RNA-binding protein interactions constrain coding sequence evolution". Molecular Biology and Evolution 34 5 (2017): 1110-1126. http://dx.doi.org/10.1093/molbev/msx061.
    Open access • Published • 10.1093/molbev/msx061
  10. Savisaar, Rosina; Hurst, Laurence D.. "Purifying Selection on Exonic Splice Enhancers in Intronless Genes". Molecular Biology and Evolution 33 6 (2016): 1396-1418. http://dx.doi.org/10.1093/molbev/msw018.
    Open access • Published • 10.1093/molbev/msw018
  11. Peluffo, Alexandre E.; Nuez, Isabelle; Debat, Vincent; Savisaar, Rosina; Stern, David L.; Orgogozo, Virginie. "A Major Locus Controls a Genital Shape Difference Involved in Reproductive Isolation Between Drosophila yakuba and Drosophila santomea". Genes | Genomes | Genetics 5 12 (2015): 2893-2901.
    Published
Magazine article
  1. Savisaar, Rosina. "Constraints on protein evolution imposed by dual coding", FUTURA, 2014
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/12/04 The dynamics of splicing (invited talk). Big Data Meets Precision Medicine. A workshop of the German-Egyptian Dialogue on tackling Precision Medicine using AI (GED-PerMedAI)
Nile University (virtual meeting)
2020/01 Footprints of splicing in sequence evolution (invited talk) The 53rd Population Genetics Group Meeting
The Population Genetics Group (Leicester, United Kingdom)
2018/12 Quantifying constraint: footprints of splicing in sequence evolution (invited talk) 3rd Egyptian Bioinformatics Workshop
Nile University (Giza, Egypt)
2015/03 Do intronless genes avoid exonic splice enhancers? (invited talk)
Beijing Proteome Research Centre (Beijing, China)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/04/01 - Current The transcriptome in hypertrophic cardiomyopathy
Co-supervisor
Universidade de Lisboa Faculdade de Medicina, Portugal
2019/11/01 - Current Tuning of protein coding gene expression by promoter-proximal convergent antisense transcription
Co-supervisor of Rui Sérgio de Sousa Luis
Universidade de Lisboa Faculdade de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018 - 2018 GW4 Introduction to Programming for Beginners (2018)
Workshop (Co-organisor)
 University of Bath, United Kingdom
2017 - 2018 The Milner Centre for Evolution Journal Club (2018)
Other (Co-organisor)
 University of Bath, United Kingdom

Committee member

Activity description
Role 		Institution / Organization
2011 - 2013 Jury and Problem Committee Member for the International Olympiad in Linguistics
Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/02/04 - 2022/04/15 Introduction to Data Analysis for Biologists (Arabic Version)
2021/10/07 - 2021/12/11 Introduction to Data Analysis for Biologists (English Version) Introduction to Data Analysis for Biologists (Outros) Instituto de Medicina Molecular, Portugal
2019/05 - 2019/07 Programming for Bioinformatics Bioinformatics (Postgraduate Certificate) Nile University, Egypt
2018/10 - 2019/07 Introduction to Bioinformatics Bioinformatics (Postgraduate Certificate) Nile University, Egypt
Distinctions

Award

2020 Castelbel Best Poster Award
Portuguese Society of Genetics, Portugal
2018 Kenneth Mather Memorial Prize
The Genetics Society, United Kingdom
2017 Ede & Ravenscroft Prize for Best Postgraduate Research Student, Runner-up

Other distinction

2020 Marie Sklodowska-Curie Actions Individual Fellowship
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions, Belgium
2019 EMBO Long-Term Fellowship
European Molecular Biology Organization, Germany
2014 Boehringer-Ingelheim Fonds PhD Fellowship
Boehringer Ingelheim Fonds, Germany
2012 Robin & Nadine Wells Scholarship
University of Oxford Saint Cross College, United Kingdom