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Manuela Carvalheiro graduated in Applied Chemistry/Biotechnology in 1991 (FCT, UNL), obtained her M.S. in Food Technology in 2001 (FCT, UNL) and completed her PhD in Pharmaceutical Technology in 2011 at the Faculty of Pharmacy, University of Lisbon. Is currently Research Assistant in the Department of Pharmacy, Pharmacology and Health Technologies at the Faculty of Pharmacy, University of Lisbon, and member of the Research Institute for Medicines (iMed.ULisboa). The scientific research area of expertise involves the design, development, and biological evaluation of Nanoparticulate Lipid-Based systems for the delivery of new chemical entities, already established chemotherapeutics and genetic drugs. The aim is to increase the therapeutic efficacy of the loaded drug, reduce their toxicity, and allow drug release at the specific site in a controlled manner. Research activity has been dedicated to the development and optimization of cost-effective lipid-based nanocarriers (liposomes, ethosomes, ultra-deformable vesicles, SLN, NLC), for selective intracellular macrophage delivery of active drugs for the treatment of Leishmania related infections exploring non-invasive routes of administration. Her work also includes the optimization of cells-based in vitro assays to assess the performance of colloidal systems in mammalian cells (cytotoxicity and internalization studies) and Leishmania parasites (susceptibility analysis of drug formulation) and establishment of animal models of human diseases for assessment of in vivo efficacy and safety. In the last few years she has been working towards the valorization of agri-food by-products through their incorporation in dermal formulations. More recently she has been involved in the establishment and optimization of a mice model of breast cancer brain metastasis for the evaluation of therapeutic efficacy of new drug candidates. She has experience in coordinating research projects as a principal investigator and participates as a researcher in several funded projects. She has supervised PhD student, MSc students, Erasmus fellow and several undergraduate students in research work. Reviewer in international peer review journals.
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Identification

Personal identification

Full name
Manuela Colla Carvalheiro

Citation names

  • Carvalheiro, Manuela
  • Carvalheiro, Manuela C
  • Carvalheiro, Manuela Colla

Author identifiers

Ciência ID
C415-C96F-C9FC
ORCID iD
0000-0002-6028-4717
Researcher Id
M-5581-2014
Scopus Author Id
57202998389

Email addresses

  • mcarvalheiro@ff.ulisboa.pt (Professional)

Telephones

Telephone
  • 217946404 Ext.: 14772 (Professional)

Websites

  • http://www.imed.ulisboa.pt/; http://www.ff.ulisboa.pt/ (Professional)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Engineering and Technology - Nano-technology
  • Engineering and Technology - Nano-technology - Nano-materials

Languages

Language Speaking Reading Writing Listening Peer-review
Italian Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2011
Concluded
 Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Liposomes as Nanosystems for the transport and Delivery of Bioactive Agents" (THESIS/DISSERTATION)
 Distinção e Luovor
2001
Concluded
 Tecnologia Alimentar / Qualidade (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Ocorrência e Distribuição de Leveduras de Contaminação Alimentar. Identificação e Caracterização Molecular." (THESIS/DISSERTATION)
 Bom com Distinção
1991
Concluded
 Química Aplicada - Biotecnologia (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2011/03/25 - Current Auxiliary Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2009/01/01 - 2011/03/24 Research Assistant (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Others

Category
Host institution 		Employer
2001/06/01 - 2008/12/31 Contrato Administrativo de Provimento Assistente de Investigação - Carreira de Investigação Instituto Nacional de Engenharia, Tecnologia e Inovação, Portugal
1999/06/30 - 2001/05/31 Contrato de trabalho a termo certo Estagiário de Investigação _ Carreira de Investigação Instituto Nacional de Engenharia, Tecnologia e Inovação, Portugal
1998/06/01 - 1999/06/29 Contrato de Técnico Superior de 2ª classe – Carreira Técnica Superior Instituto Nacional de Engenharia, Tecnologia e Inovação, Portugal
1995/01/01 - 1998/05/31 Grant - junior researcher Instituto Nacional de Engenharia e Tecnologia Industrial, Portugal
1992/11/01 - 1994/11/01 Master student Fundação para a Ciência e a Tecnologia, Portugal
1991/02/01 - 1992/10/01 Grant student in PEDIP JTI program Instituto Nacional de Engenharia e Tecnologia Industrial, Portugal
Projects

Contract

Designation Funders
2021 - 2024 Targeting TLR2 for improved veterinary vaccines
PTDC/CVT-CVT/4599/2021
 Fundação para a Ciência e a Tecnologia
2021/01/10 - 2023/06 Detect, prevent, eradicate: a multi-step strategy to abrogate brain metastasization of breast cancer
FCT-PTDC/MED-ONC/29402/2017
Co-orientador de aluno de PhD que desenvolveu o trabalho experimental para a obtenção do grau no âmbito deste projeto
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2021 - 2023 Tackling trypanosomiasis cardiomyopathy with microRNAs and tridimensional (3D) cell models
EXPL/CVT-CVT/0175/2021
 Fundação para a Ciência e a Tecnologia
2018 - 2022 Sustainable, Safe, and Scalable (3S) approach for lycopene valorization: driving the knowledge toward an academia-industry interface for topical treatment of inflammation
PTDC/SAU-SER/30197/2017
Researcher
Fundação para a Ciência e a Tecnologia
2018 - 2022 Phage-Enzybiotic : dealing with critical pathogenic antibiotic-resistant bacteria
PTDC/BTM-SAL/28978/2017
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2022 Programming the type and localization of adaptive immunity by targeting TLR2: a strategy for the development of novel veterinary vaccines
C493040443-00089191
PTDC/CVT-CVT/31840/2017
Researcher
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2016 - 2020 VIH_TRANFERSOME: Inibidor de fusão veiculado em Transfersomas para libertação transdérmica
PGG/006/2016
Researcher
Gilead Génese, Portugal
 Gilead Génese
Concluded
2019/01/01 - 2019/12/31 Instituto de Investigação do Medicamento
UID/DTP/04138/2019
154706UID
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017/09 - 2019/09 Targeted liposomal antioxidant and anti-inflammatory therapy for liver ischemic reperfusion injury
Farm-ID 200009
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Phospholipid Forschungszentrum e V
2013 - 2015 Priming of Mesenchymal Stromal Cells from the Umbilical Cord Tissue (UC X®) as a Means of Incrementing Their Therapeutic Potency for Rheumatoid Arthritis
EXPL/DTP-FTO/0308/2013
 Fundação para a Ciência e a Tecnologia
2013/07 - 2014/12 Cutaneous leishmaniasis: an innovative idea to explore the topical treatment of skin lesions
EXPL/CVT-EPI/0862/2012
Principal investigator
Fundação para a Ciência e a Tecnologia
2012 - 2014 Helicobacter pylori phages: translating an underestimated phenomenon into a therapeutic application
PTDC/EBB-EBI/119860/2010
 Fundação para a Ciência e a Tecnologia
2011/01/01 - 2013/12/31 Projecto Estratégico - UI 4013 - 2011-2012
PEst-OE/SAU/UI4013/2011
PEst-OE/EQB/LA0004/2011
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Universidade Nova de Lisboa Medical School, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Centro de Estudos de Recursos Naturais Ambiente e Sociedade, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2012 Development of new polymer-liposome complexes combining experimental and computational approaches
PTDC/EQU-EPR/099226/2008
 Fundação para a Ciência e a Tecnologia
2010 - 2012 A challenge for the treatment of parasitic diseases: rational design of Trifluralin derivatives and appropriate nanoformulations
PTDC/CVT/098290/2008
 Fundação para a Ciência e a Tecnologia
2005 - 2008 Microtubule Inhibitor Formulations Against Zoonotic Visceral Leishmaniasis
POCI/CVT/56995/2004
 Fundação para a Ciência e a Tecnologia
2003 - 2006 Targeted Antisense Therapy: A Novel Approach for the Treatment of Human Small Cell Lung Cancer
POCTI/FCB/48487/2002
 Fundação para a Ciência e a Tecnologia
2002 - 2005 Liposomal Formulations of Dinitroanilines for the Treatment of Canine Leishmaniasis.
POCTI/2000/FCB/35249
 Fundação para a Ciência e a Tecnologia
1999 - 2000 SUBERIMUNE_Synthesis of adjuvants for vaccines obtained from wastes of beer and cork industries.
LP089-P31B-05/97
 Agência Nacional de Inovação SA
1997 - 2000 Chemically modified immunomodulators associated to colloidal carriers for cancer therapy
Praxis XXI Ref. 2/2.1/SAU/1381/95,
 Fundação para a Ciência e a Tecnologia
1995 - 2000 Liposome-Encapsulated Drugs for the Therapy of Leishmanial Infections
Science for Stability PO-INFECTION 941457
 NATO
1993 - 1996 Bioconjugados e Vectores para Fins Terapêuticos
PBIC/C/SAU/1551/92
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Book chapter
  1. Faria-Silva, Ana Catarina; Mota, Ana Luísa; Costa, Ana Margarida; Silva, Ana Margarida; Ascenso, Andreia (761B-404D-2C83); Reis, Catarina Pinto; Marto, Joana; et al. "Application of natural raw materials for development of cosmetics through nanotechnology". In Nanotechnology for the Preparation of Cosmetics using Plant-based Extracts, edited by Mohammad Jawaid; Siti Hamidah Mohd Setapar; Akil Ahmad. Elsevier, 2022.
    Accepted
  2. Simões, S.; Costa, A.; Faria-Silva, A.C.; Ascenso, A.; Marto, J.; Carvalheiro, M.; Gonçalves, L.M.; et al. "Sustainable valorization of food-processing industry by-products: challenges and opportunities to obtain bioactive compounds". In Valorization of Agri-Food Wastes and By-Products, edited by Rajeev Bhat, 619-644. Elsevier, 2021.
    Published • 10.1016/b978-0-12-824044-1.00023-4
  3. Faria-Silva, Ana Catarina; Costa, Ana Margarida; Ascenso, Andreia; Ribeiro, Helena Margarida; Marto, Joana; Gonçalves, Lídia Maria; Carvalheiro, Manuela; Simões, Sandra. "Nanoemulsions for cosmetic products". In Nanocosmetics, 59-77. Elsevier, 2020.
    Published • 10.1016/b978-0-12-822286-7.00004-8
  4. Carvalheiro, Manuela; Gaspar, Maria Manuela; Simões, Sandra. "Lipid-Based Nanocarriers for the Treatment of Infected Skin Lesions". In Carrier Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorder, edited by Helena M. Ribeiro; Simões, Sandra; Ascenso, Andreia (761B-404D-2C83). Nova Iorque, United States: Jenny Stanford Publishing, 2017.
    10.4324/9781315364476-11
Conference abstract
  1. Weber, Juliana; Santos-Gomes, Gabriela; Alexandre-Pires, Graça; Pereira da Fonseca, Isabel; Carvalheiro, Manuela Colla; Ana Valério-Bolas; Rodrigues, Armanda; Wilson Talhão Antunes. Corresponding author: Santos-Gomes, Gabriela. "Effect of extracellular vesicles sheed by Leishmania shawi on immunomodulation of murine macrophages". Paper presented in WORLDLEISH7, Cartagena, 2022.
    Submitted
Conference paper
  1. Menezes, Ana Catarina; Oliveira, José Miguel; Carvalheiro, Manuela; Oliveira, Helena; Ascenso, Andreia. "Agonistas e antagonistas dos recetores 5-HT1A e 5-HT2A no tratamento do cancro da pele". 2016.
    10.34624/captar.v6i1.12737
  2. Gomes, M.; Lehours, P.; Gaspar, M.; Colla Carvalheiro, M.; Vale, F. F.. "Liposomes as Drug Delivery Systems Against Helicobacter Pylori". Paper presented in 26th International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation and Gastric Cancer, Madrid, 2013.
    Published
Conference poster
  1. Faria-Silva, Catarina; Scavone, Denise; Marto, Joana; Simões, Pedro; Carvalheiro, Manuela; Simões, Sandra. "Development of an alpha-tomatine foam for cutaneous application: a sustainable approach for saponins use". Paper presented in XV Spanish-Portuguese Conference on Controlled Drug Delivery, 2024.
  2. Faria-Silva, Catarina; Poças, Marta; Cunha, Daniela; Marto, Joana; Simões, Pedro; Carvalheiro, Manuela; Simões, Sandra. "Green Tomato Extract mediated biosynthesis of Silver Nanoparticles. Biosynthesis, characterization and biological properties". Paper presented in XV Spanish-Portuguese Conference on Controlled Drug Delivery, 2024.
  3. Faria-Silva, Catarina; Scavone, Denise; Marto, Joana; Simões, Pedro; Carvalheiro, Manuela; Simões, Sandra. "Alpha-tomatine: a promising natural ingredient for skin care formulations". Paper presented in Skin and Formulation, 6th Symposium, 2023.
  4. Faria-Silva, Catarina; Scavone, Denise; Santos, Maria Soledade; Simões, Pedro; Carvalheiro, Manuela; Simões, Sandra. "Characterization of surfactants present in a tomatine-containing extract". Paper presented in 14th iMed.ULisboa Postgraduate Students Meeting, 2023.
  5. Faria-Silva, Catarina; Scavone, Denise; Santos, Maria Soledade; Simões, Pedro; Carvalheiro, Manuela; Simões, Sandra. "Characterization of a natural extract derived from green tomato". Paper presented in 15º Encontro Nacional de Química Física, 2023.
  6. Faria-Silva, Catarina; Scavone, Denise; Simões, Pedro; Carvalheiro, Manuela; Simões, Sandra. "Green tomato-derived foam: simultaneous use of plant glycoalkaloids as excipients and as active substances". Paper presented in IV Young Scientist Meeting of the Spanish Portuguese Local Chapter - Controlled Release Society (SPC-CRS), 2023.
  7. Cunha, Daniela; Faria-Silva, Catarina; Marto, Joana; Simões, Pedro; Carvalheiro, Manuela; Simões, Sandra. "Silver nanoparticles synthesis using Green Tomatoes Extract: Preliminary studies". Paper presented in IV Young Scientist Meeting of the Spanish Portuguese Local Chapter - Controlled Release Society (SPC-CRS), 2023.
  8. Faria-Silva, Catarina; Simões, Pedro; Carvalheiro, Manuela; Simões, Sandra. "Tomatine extracted from green tomatoes: the beginning of a new topical anti leishmanial treatment?". Paper presented in 1st Egas Moniz One Health Simposium, 2022.
  9. Faria-Silva, AC; Eleutério, Carla Vânia; Simões, Pedro; Carvalheiro, Manuela; Simões, Sandra. "Valorization of natural glycoalkaloids from tomato: an optimized HPLC method for the quantification of tomatine". Paper presented in 13th iMed.ULisboa Postgraduate Students Meeting, 2022.
  10. Ferreira-Silva, Margarida; Faria-Silva, C.; Carvalheiro, Manuela; Simões, Sandra; Fernandes, Eduarda; Baptista, Pedro; Alexandra R Fernandes; Corvo, M. Luisa. "Quercetin liposomes for hepatic ischemia and reperfusion injury a promising therapeutic approach". Paper presented in First Symposium on Advanced Technologies on Drug Delivery, 2021.
  11. Silvestre, Rafaela; Dionisio Lopes, Margarida; Godinho-Pereira, Joana; Figueira, Inês; Carvalheiro, Manuela Colla; Corvo, M. Luisa; Maria Alexandra de Oliveira Silva Braga Pedreira de Brito. "Boosting the blood-brain barrier: a way to prevent breast cancer brain metastases". Paper presented in imed Meeting 2021, 2021.
  12. Catarina Faria-Silva; Carla V. Eleutério; Bruno Pedras; Marta Marques; Pedro Simões; Carvalheiro, Manuela; Sandra Simões. "Alpha-tomatine extracted from food waste: unveiling its antioxidant and anti-inflammatory properties". Paper presented in iMed.Ulisboa, 2021.
  13. Carvalheiro, Manuela Colla; Varrica, Carla G.; Faria-Silva, Catarina; Sandri, Giuseppina; Simões, Sandra. "Alopurinol-loaded Nanostructured Lipid Carriers for Topical Application: in vitro and in vivo evaluation.". Paper presented in XIII Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  14. Ferreira-Silva, Margarida; Faria-Silva, Catarina; Carvalheiro, Manuela Colla; Simões, Sandra; Fernandes, Eduarda; Baptista, Pedro Viana; Fernandes, Alexandra; Corvo, M. Luísa. "Evaluation of anti-inflammatory effect of quercetin liposomes in hepatic ischemia and reperfusion injury". Paper presented in XIII Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  15. Ferreira-Silva, Margarida; Faria-Silva, Catarina; Carvalheiro, Manuela Colla; Baptista, Pedro V; Fernandes, Eduarda; Fernandes, Alexandra R.; Corvo, M. Luísa. "Evaluation of anti-inflammatory efficacy of liposomal formulations developed for hepatic ischemia and reperfusion injury’s treatment.". Paper presented in 6th International Symposium on Phospholipids in Pharmaceutical Research, 2019.
  16. Vieira, Jennifer; Faria-Silva, Catarina; Eleutério, Carla V.; Marto, Joana; Simões, Sandra; Carvalheiro, Manuela Colla. "Soybean phosphatidylcholine containing deformable vesicles as topical formulations for Amphotericin B.". Paper presented in 6th International Symposium on Phospholipids in Pharmaceutical Research, 2019.
  17. Ferreira-Silva, Margarida; Faria-Silva, Catarina; Carvalheiro, Manuela Colla; Baptista, Pedro V; Metselaar, Bart; Corvo, M. Luísa; Fernandes, Alexandra R.. "Assessment Of Anti-inflammatory Efficacy Of Liposomal Formulations Developed For The Treatment Of Hepatic Ischemia And Reperfusion Injury.". Paper presented in 2019 Controlled Release Society Annual Meeting & Exposition, 2019.
  18. Faria-Silva, Catarina; Ferreira-Silva, Margarida; Carvalheiro, Manuela Colla; Simões, Sandra; Fernandes, Alexandra R.; Corvo, M. Luísa; Baptista, Pedro V; Fernandes, Eduarda; Fernandes, Alexandra. "Development of Indomethacin Liposomal Formulations for Hepatic Ischemia/Reperfusion Injury Prevention.". Paper presented in 2019 Controlled Release Society Annual Meeting & Exposition., 2019.
  19. Camões, Sérgio P; Gaspar, Maria Manuela; Rodrigues, Joana S; Carvalheiro, Manuela Colla; Simões, Sandra; Santos, JM; Miranda, Joana P. "Using the secretome of 3D-cultured mesenchymal stromal cells from the umbilical cord tissue for the treatment of rheumatoid arthritis". Paper presented in 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapy, 2019.
  20. Aguiar, Sandra I; Gaspar, Maria Manuela; André, Ana; Martins, Diana; Ferreira, Marta; Carvalheiro, Manuela; Neves, Vera; et al. "sdAb-immunoliposomes for brain targeting and drug delivery.". Paper presented in PEGS Europe, 2018.
  21. Ferreira-Silva, Margarida; Faria-Silva, Ana Catarina; Carvalheiro, Manuela; Baptista, Pedro Viana; Fernandes, Eduarda; Fernandes, Alexandra; Corvo, Maria Luísa. "Development of Anti-Inflammatory Liposomal Formulations for Hepatic Ischemia/Reperfusion Injury.". Paper presented in 10th iMed.ULisboa and 3rd i3du Postgraduate Students Meeting., 2018.
  22. Ferreira-Silva, Margarida; Carvalheiro, Manuela Colla; Holovanchuk, Denys; Soares, Helena; H. Susana Marinho; Corvo, M. Luisa. "Antagonist G-labeled long circulating liposomes actively targeted to lung tumor cells". Paper presented in 5th International Symposium on Phospholipids in Pharmaceutical Research;, 2017.
  23. Carvalheiro, Manuela; F. Silva, A. Catarina; Esteves, Alexandra M; Eleutério, Carla V.; Cruz, M. Eugénia; Gaspar, M. Manuela; Simões, Sandra. "Lipid-based delivery systems for dinitroanilines in treatment of L. major skin lesions.". Paper presented in 6th World Congress on Leishmaniasis, 2017.
  24. Ferreira-Silva, Margarida; Carvalheiro, Manuela Colla; Holovanchuk, Denys; Soares, Helena; Marinho, H. Susana; Corvo, M. Luisa. "Active targeting of lung tumor cells using antagonist G labeled long circulating liposomes". Paper presented in 8th iMed.ULisboa Postgraduate Students Meeting & 1st i3DU Meeting, 2016.
  25. Carvalheiro, Manuela; F. Silva, A. Catarina; Costa, A. Margarida; Esteves Alexandra; Eleutério, Carla V.; Gaspar, M. Manuela; Simões, Sandra. "Ethosomes containing TFL-A for topical treatment of L. major skin lesions". Paper presented in COST Action 1307. Chemotherapy toward diseases caused by endoparasites., 2016.
  26. Menezes, Ana Catarina; Ferreira de Oliveira, José Miguel P.; Carvalheiro, Manuela; Oliveira, Helena; ascenso, andreia. "Cytotoxicity of the Serotonergic Drug 1-(1-naphthyl)piperazine in Human MNT-1 Melanoma Cells.". Paper presented in 51st Congress of the European Societies of Toxicology (EUROTOX 2015), 2015.
  27. Menezes, Ana Catarina; Ferreira de Oliveira, José Miguel P.; Carvalheiro, Manuela; Oliveira, Helena; ascenso, andreia. "Management of Skin Cancer by Agonists of 5-HT1A and Antagonists of 5-HT2A Receptors.". Paper presented in IV Encontro Nacional de Pós-Graduação em Ciências Biológicas, 2015.
Journal article
  1. Larysa Grygor’yeva; Manuela Colla Carvalheiro; Sandra Simões. "Topical Application onto the Eyelid Skin: Is it a Feasible Delivery Route of Ophthalmic Drugs?". Mini-Reviews in Medicinal Chemistry (2025): https://doi.org/10.2174/0113895575358373241220043138.
    10.2174/0113895575358373241220043138
  2. Daniela Cunha; Catarina Faria-Silva; Filomena A. Carvalho; Lia Ascensão; Pedro Simões; Manuela Carvalheiro; Sandra Simões. "In Vitro, Ex Vivo, and In Vivo Evaluation of Silver Nanoparticles Synthesized Using Green Tomato Extract: Perspectives on Topical Application". Applied Sciences (2024): https://doi.org/10.3390/app14167309.
    10.3390/app14167309
  3. Faria-Silva, Catarina; Eleutério, Carla V.; Simões, Pedro; Carvalheiro, Manuela; Simões, Sandra. "A new method for quantification of tomatine-enriched extracts". Journal of the Science of Food and Agriculture (2024): http://dx.doi.org/10.1002/jsfa.13683.
    10.1002/jsfa.13683
  4. Mota, Joana; Faria-Silva, Catarina; Resendes, Ana; Santos, Maria Isabel; Carvalheiro, Manuela Colla; Lima, Ana; Simões, Sandra. "Silymarin inhibits dermal gelatinolytic activity and reduces cutaneous inflammation". Natural Product Research (2024): 1-12. http://dx.doi.org/10.1080/14786419.2024.2347452.
    10.1080/14786419.2024.2347452
  5. Joana Godinho-Pereira; Daniela Vaz; Inês Figueira; Joana Aniceto-Romão; Istvan Krizbai; Rui Malhó; João Rocha; et al. "Breast Cancer Brain Metastases: Implementation and Characterization of a Mouse Model Relying on Malignant Cells Inoculation in the Carotid Artery". Cells (2023): https://doi.org/10.3390/cells12162076.
    10.3390/cells12162076
  6. Juliana Inês Weber; Armanda Viana Rodrigues; Ana Valério-Bolas; Telmo Nunes; Manuela Carvalheiro; Wilson Antunes; Graça Alexandre-Pires; Isabel Pereira da Fonseca; Gabriela Santos-Gomes. "Insights on Host–Parasite Immunomodulation Mediated by Extracellular Vesicles of Cutaneous Leishmania shawi and Leishmania guyanensis". Cells (2023): https://doi.org/10.3390/cells12081101.
    10.3390/cells12081101
  7. Faria-Silva, Catarina; de Sousa, Miriam; Carvalheiro, Manuela Colla; Simões, Pedro; Simões, Sandra. "Alpha-tomatine and the two sides of the same coin: An anti-nutritional glycoalkaloid with potential in human health". Food Chemistry 391 (2022): 133261. http://dx.doi.org/10.1016/j.foodchem.2022.133261.
    10.1016/j.foodchem.2022.133261
  8. Diana Morais; Luís Tanoeiro; Andreia Marques; Tiago Gonçalves; Aida Duarte; António Matos; Joana Vital; et al. "Liposomal Delivery of Newly Identified Prophage Lysins in a Pseudomonas aeruginosa Model". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms231710143.
    10.3390/ijms231710143
  9. Carvalheiro, Manuela; Ferreira-Silva, Margarida; Holovanchuk, Denys; H. Susana Marinho; Moreira, João Nuno; Soares, Helena; Corvo, Maria Luisa ; Cruz, M Eugénia M. Corresponding author: Carvalheiro, Manuela. "Antagonist G-targeted liposomes for improved delivery of anticancer drugs in small cell lung carcinoma". International Journal of Pharmaceutics 612 (2022): 121380-121380. http://dx.doi.org/10.1016/j.ijpharm.2021.121380.
    10.1016/j.ijpharm.2021.121380
  10. Margarida Ferreira-Silva; Ana Catarina Faria da Silva Severiano; Manuela Carvalheiro; Sandra Simões; H. Susana Marinho; Paulo Marcelino; Maria Celeste Campos; et al. "Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/1/104.
    10.3390/pharmaceutics14010104
  11. Mikel Etxebeste-Mitxeltorena; Esther Moreno; Manuela Carvalheiro; Alba Calvo; Iñigo Navarro-Blasco; Elena González-Peñas; José I. Álvarez-Galindo; et al. "Oral Efficacy of a Diselenide Compound Loaded in Nanostructured Lipid Carriers in a Murine Model of Visceral Leishmaniasis". ACS Infectious Diseases 7 12 (2021): 3197-3209. https://doi.org/10.1021/acsinfecdis.1c00394.
    10.1021/acsinfecdis.1c00394
  12. Carla Varrica; Manuela Carvalheiro; Catarina Faria-Silva; Carla Eleutério; Giuseppina Sandri; Sandra Simões. "Topical Allopurinol-Loaded Nanostructured Lipid Carriers: A Novel Approach for Wound Healing Management". Bioengineering (2021): https://doi.org/10.3390/bioengineering8120192.
    10.3390/bioengineering8120192
  13. Luciana F. C. Girão; Manuela Colla Carvalheiro; Margarida Ferreira-Silva; Surza L. G. da Rocha; Jonas Perales; M. Bárbara F. Martins; Maria Antonieta Ferrara; Elba P. S. Bon; M. Luísa Corvo. "ASP-Enzymosomes with Saccharomyces cerevisiae Asparaginase II Expressed in Pichia pastoris: Formulation Design and In Vitro Studies of a Potential Antileukemic Drug". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms222011120.
    10.3390/ijms222011120
  14. Rita F. Cunha; Sandra Simões; Manuela Carvalheiro; José M. Azevedo Pereira; Quirina Costa; Andreia Ascenso. "Novel Antiretroviral Therapeutic Strategies for HIV". Molecules 26 17 (2021): 5305-5305. https://doi.org/10.3390/molecules26175305.
    10.3390/molecules26175305
  15. Maria Quitério; Sandra Simões; Andreia Ascenso; Manuela Carvalheiro; Ana Paula Leandro; Isabel Correia; Ana Silveira Viana; et al. "Development of a Topical Insulin Polymeric Nanoformulation for Skin Burn Regeneration: An Experimental Approach". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22084087.
    10.3390/ijms22084087
  16. Mehdi Sagha Kahvaz; Shahrzad Soltani; Sheyda Soltani; Manuela Colla Carvalheiro; Masoud Foroutan. "Low Serum Levels of Selenium, Zinc, Iron, and Zinc/Copper Ratio in an Endemic Region of Cutaneous Leishmaniasis in Southwest Iran". Biological Trace Element Research (2021): https://doi.org/10.1007/s12011-020-02271-z.
    10.1007/s12011-020-02271-z
  17. Carvalheiro, Manuela; Vieira, Jennifer; Faria-Silva, Catarina; Marto, Joana; Simões, Sandra. "Amphotericin B-loaded deformable lipid vesicles for topical treatment of cutaneous leishmaniasis skin lesions". Drug Delivery and Translational Research (2021): http://dx.doi.org/10.1007/s13346-021-00910-z.
    10.1007/s13346-021-00910-z
  18. Varrica, Carla; Dias, Helena Sofia; Reis, Catarina; Carvalheiro, Manuela; Simões, Sandra. "Targeted delivery in scleroderma fibrosis". Autoimmunity Reviews 20 2 (2021): 102730. http://dx.doi.org/10.1016/j.autrev.2020.102730.
    10.1016/j.autrev.2020.102730
  19. Pinto, Luciana Matos Alves; Adeoye, Oluwatomide; Thomasi, Sérgio Scherrer; Francisco, Ana Paula; Carvalheiro, Manuela Colla; Cabral-Marques, Helena. "Preparation and characterization of a synthetic curcumin analog inclusion complex and preliminary evaluation of in vitro antileishmanial activity". International Journal of Pharmaceutics 589 (2020): 119764. http://dx.doi.org/10.1016/j.ijpharm.2020.119764.
    10.1016/j.ijpharm.2020.119764
  20. Mota, Ana Henriques; Andrade, Joana M.; Rodrigues, Maria João; Custódio, Luísa; Bronze, Maria Rosário; Duarte, Noélia; Baby, André; et al. "Synchronous insight of in vitro and in vivo biological activities of Sambucus nigra L. extracts for industrial uses". Industrial Crops and Products 154 (2020): 112709. http://dx.doi.org/10.1016/j.indcrop.2020.112709.
    Published • 10.1016/j.indcrop.2020.112709
  21. Faria-Silva, Catarina; Ascenso, Andreia; Costa, Ana M.; Marto, Joana; Carvalheiro, Manuela; Ribeiro, Helena Margarida; Simões, Sandra. "Feeding the skin: A new trend in food and cosmetics convergence". Trends in Food Science & Technology 95 (2020): 21-32. http://dx.doi.org/10.1016/j.tifs.2019.11.015.
    Published • 10.1016/j.tifs.2019.11.015
  22. Pedrosa, Pedro; Corvo, M. Luísa; Ferreira-Silva, Margarida; Martins, Pedro; Carvalheiro, Manuela Colla; Costa, Pedro M.; Martins, Carla; et al. "Targeting Cancer Resistance via Multifunctional Gold Nanoparticles". International Journal of Molecular Sciences 20 21 (2019): 5510. http://dx.doi.org/10.3390/ijms20215510.
    Open access • 10.3390/ijms20215510
  23. Miranda, Joana P.; Camões, Sérgio P.; Gaspar, Maria M.; Rodrigues, Joana S.; Carvalheiro, Manuela; Bárcia, Rita N.; Cruz, Pedro; et al. "The Secretome Derived From 3D-Cultured Umbilical Cord Tissue MSCs Counteracts Manifestations Typifying Rheumatoid Arthritis". Frontiers in Immunology 10 (2019): http://dx.doi.org/10.3389/fimmu.2019.00018.
    10.3389/fimmu.2019.00018
  24. Menezes, A.C.; Carvalheiro, M.; Ferreira de Oliveira, J.M.P.; Ascenso, A.; Oliveira, H.. "Cytotoxic effect of the serotonergic drug 1-(1-Naphthyl)piperazine against melanoma cells". Toxicology in Vitro 47 (2018): 72-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034571213&partnerID=MN8TOARS.
    10.1016/j.tiv.2017.11.011
  25. Fernandes, Alexandra R.; Jesus, João; Martins, Pedro; Figueiredo, Sara; Rosa, Daniela; Martins, Luísa M.R.D.R.S.; Corvo, Maria Luísa; et al. "Multifunctional gold-nanoparticles: A nanovectorization tool for the targeted delivery of novel chemotherapeutic agents". Journal of Controlled Release 245 (2017): 52-61. https://doi.org/10.1016/j.jconrel.2016.11.021.
    10.1016/j.jconrel.2016.11.021
  26. Raposo, L.R.; Roma-Rodrigues, C.; Faísca, P.; Alves, M.; Henriques, J.; Carvalheiro, M.C.; Corvo, M.L.; et al. "Immortalization and characterization of a new canine mammary tumour cell line FR37-CMT". Veterinary and Comparative Oncology 15 3 (2017): 952-967. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964950972&partnerID=MN8TOARS.
    10.1111/vco.12235
  27. Bárcia, R.N.; Santos, J.M.; Teixeira, M.; Filipe, M.; Pereira, A.R.S.; Ministro, A.; Água-Doce, A.; et al. "Umbilical cord tissue–derived mesenchymal stromal cells maintain immunomodulatory and angiogenic potencies after cryopreservation and subsequent thawing". Cytotherapy 19 3 (2017): 360-370. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009396582&partnerID=MN8TOARS.
    10.1016/j.jcyt.2016.11.008
  28. Simões, M.G.; Alves, P.; Carvalheiro, M.; Simões, P.N.. "Stability effect of cholesterol-poly(acrylic acid) in a stimuli-responsive polymer-liposome complex obtained from soybean lecithin for controlled drug delivery". Colloids and Surfaces B: Biointerfaces 152 (2017): 103-113. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009212421&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2017.01.002
  29. Lopes, Rui M; Pereira, Joana; Esteves, M Alexandra; Gaspar, M Manuela; Carvalheiro, Manuela; Eleutério, Carla V; Gonçalves, Lídia; et al. "Lipid-based nanoformulations of trifluralin analogs in the management of Leishmania infantum infections". Nanomedicine 11 2 (2016): 153-170. http://dx.doi.org/10.2217/nnm.15.190.
    10.2217/nnm.15.190
  30. Simões, S.; Carvalheiro, M.; Gaspar, M.M.. "Lipid-based nanocarriers for cutaneous leishmaniais and buruli ulcer management". Current Pharmaceutical Design 22 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85010671889&partnerID=MN8TOARS.
    10.2174/1381612822666160701083812
  31. Carvalheiro, M.; Esteves, M.A.; Santos-Mateus, D.; Lopes, R.M.; Rodrigues, M.A.; Eleutério, C.V.; Scoulica, E.; Santos-Gomes, G.; Cruz, M.E.M.. "Hemisynthetic trifluralin analogues incorporated in liposomes for the treatment of leishmanial infections". European Journal of Pharmaceutics and Biopharmaceutics 93 (2015): 346-352. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930212963&partnerID=MN8TOARS.
    10.1016/j.ejpb.2015.04.018
  32. Lopes, R.M.; Gaspar, M.M.; Pereira, J.; Eleutério, C.V.; Carvalheiro, M.; Almeida, A.J.; Cruz, M.E.M.. "Liposomes versus Lipid Nanoparticles: Comparative Study of Lipid-Based Systems as Oryzalin Carriers for the Treatment of Leishmaniasis". Journal of Biomedical Nanotechnology 10 12 (2014): 3647-3657. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928499115&partnerID=MN8TOARS.
    10.1166/jbn.2014.1874
  33. Gomes, M.; Gaspar, M.; Carvalheiro, M.; Cruz, M. E. M.; Vale, F. F.; Gaspar, Maria Manuela; Carvalheiro, Manuela; Cruz, Maria; Vale, Filipa. "FUSOGENIC LIPOSOMES AS PROMISING DELIVERY SYSTEMS AGAINST HELICOBACTER PYLORI". Helicobacter 19 (2014): 137-138. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000341623900226&KeyUID=WOS:000341623900226.
    Published
  34. Lopes, R.M.; Corvo, M.L.; Eleutério, C.V.; Carvalheiro, M.C.; Scoulica, E.; Cruz, M.E.M.. "Formulation of oryzalin (ORZ) liposomes: In vitro studies and in vivo fate". European Journal of Pharmaceutics and Biopharmaceutics 82 2 (2012): 281-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867877363&partnerID=MN8TOARS.
    10.1016/j.ejpb.2012.06.013
  35. Carvalheiro, M.; Jorge, J.; Eleutério, C.; Pinhal, A.F.; Sousa, A.C.; Morais, J.G.; Cruz, M.E.M.. "Trifluralin liposomal formulations active against Leishmania donovani infections". European Journal of Pharmaceutics and Biopharmaceutics 71 2 (2009): 292-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-59649084848&partnerID=MN8TOARS.
    10.1016/j.ejpb.2008.08.001
  36. Marques, C.; Carvalheiro, M.; Pereira, M.A.; Jorge, J.; Cruz, M.E.M.; Santos-Gomes, G.M.. "Efficacy of the liposome trifluralin in the treatment of experimental canine leishmaniosis". Veterinary Journal 178 1 (2008): 133-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-50449108454&partnerID=MN8TOARS.
    10.1016/j.tvjl.2007.07.016
Newspaper article
  1. Carvalheiro, Manuela; Faria-Silva, Ana Catarina; Simões P; Bellofatto M; Mota J. "Eco-extracted a-Tomatine as an Antioxidant for Natural Soap", Cosmetics & Toiletries, 2023
Thesis / Dissertation
  1. Carvalheiro, Manuela; Carvalheiro, Manuela. "Liposomes as Nanosytems for the Transport and Delivery of Bioactive Agents". PhD, 2011. http://hdl.handle.net/10451/2990.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/07/22 Amphotericin B Deformable Lipid Carriers for Topical Treatment of Cutaneous Leishmaniasis 46th Controlled Release Society (CRS) Annual Meeting and Exposition
Controlled Release Society (Valencia, Spain)
2017/05/17 Nanoformulations of trifluralin analogues 6th World Congress on Leishmaniasis
Instituto de Salud Carlos III; Drugs for Neglected Diseases initiative (DNDi) (Toledo, Spain)
2016 Liposomes versus lipid nanoparticles as tools to enhance antileishmanial drugs. Meeting of WG 1 and 4 on: Targeting metabolism and transport in parasites: drugs and delivery systems. Cost Action 1307: Chemotherapy Towards Diseases Caused by Endoparasites.
I3S; ICBAS (Porto, Portugal)
2013/05/16 Hemi-synthetic dinitroanilines in liposomes: combined strategies for improving treatment of Leishmania infantum infection 5th World Congress on Leishmaniasis
Oswaldo Cruz Foundation; Brazilian Society of Tropical Medicine; Brazilian Society of Protozoology; Brazilian Society of Parasitology (Porto de Galinhas, Pernambuco, Brazil)
2011/09/09 Novel drugs and non-conventional formulations as tools for the treatment of Leishmania infections New Indigo Workshop – Antiparasitic and Antitumor Drugs
IBMC (Porto, Portugal)
2009/02/18 Liposomal Trifluralin and Derivatives as Antileishmanial Agents 1st Post-Graduated iMed.UL Students Meeting
Faculdade de Farmácia, Universidade de Lisboa (Lisboa, Portugal)
2006/10/24 Antagonist G targeted stabilized antisense-lipid particles (SALP-G): a novel vector for delivery of antisense oligonucleotides to Small Cell Lung Cancer VII Spanish-Portuguese Conference on Controlled Drug Delivery
Faculty of Pharmacy, University of Navarra (Pamplona, Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - Current Biogenic Synthesis of Silver Nanoparticles
Co-supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/02 - Current Inside and Beyond the Colour: unveiling the therapeutic potential of topical glycoalkaloids from green tomatoes
Co-supervisor
2019/10/01 - Current The blood brain barrier in brain metastatization of breast cancer: A source of biomarkers, a target for modulation and an obstacle to overcome
Co-supervisor
 Farmácia Ramo Biologia Molecular (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/10/01 - 2025 Development of a formulation for the lyophilization of bacteriophages of Pseudomonas aeruginosa within the context of respiratory infections
Co-supervisor
 Mestrado em Ciências Biofarmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

TechnoPhage SA, Portugal
2022 - 2023 Formulações Lipossomais de Glucocorticóides para o tratamento da Artrite Reumatóide: Preparação, caracterização e avaliação in vitro.
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - 2023 Transdermal eyelid delivery for treatment of ophtalmic diseases
Co-supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/09 - 2021/12 Preserving the blood-brain barrier: a way of preventing breast cancer brain metastases
Co-supervisor
2019/01/07 - 2019/05/05 Lipid-based nanoformulations of novel seleno-compounds with anti-leishmania activity. Design and development of advanced nanoparticulate drug carrier systems for overcoming biological barriers, particularly for fighting infectious diseases, such as leishmaniasis. Physicochemical, biological (in vitro) and pre-clinical evaluation of advanced drug therapy systems.
Co-supervisor
 Farmacia + Nutrición Humana y Dietética (PhD)
Universidad de Navarra Facultad de Farmacia y Nutrición, Spain
2018 - 2018 Lipid-Based Colloidal Systems for Skin Delivery of Anti-Leishmanial Drugs
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/02/12 - 2017/08/05 Advanced Lipid Carriers for Topical Treatment of Cutaneous Leishmaniasis. To develop and evaluate lipid nanocarriers as systems for topical administration of drugs: - Preparation and physico-chemical characterization of nanocarriers containing antileishmanial agents - In vitro evaluation of permeation and skin retention - In vitro evaluation of biological activity ERASMUS Programm
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2017 Formulations of Ethosomes with Amphotericin B (AmB) as an alternative for Cutaneous Leishmaniasis (CL) Treatment
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016 Lipid-Based Vesicles for Oryzalin Incorporation. Preparation, Characterisation and in vitro Studies
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016 Development and Characterisation of Lipid-Based Systems for a Bioactive Agent
Supervisor
 Mestrado Integrado em Ciências Farmacêuticas (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/09 - 2014/02 Pesquisa de proteínas líticas fágicas e formulações lipossomais para a sua entrega a Helicobacter pylori
Co-supervisor
 Engenharia Biomédica (Master)
Universidade Católica Portuguesa, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2007/06/10 - 2007/06/15 The ESF Summer School has been designed to provide an intensive state-of the- art training across all of the sub-disciplines of Nanomedicine, and to foster discussion and exchange of ideas. The lectures, tutorials and interactive workshops will particularly cover all aspects that are needed to transfer new nanotechnologies from bench to bedside – from materials science and engineering to clinical need, from rational design of nanopharmaceuticals, imaging agents and constructs for tissue engineering to safe and practical development.
Other
 1st European Science Foundation Summer School in Nanomedicine
European Science Foundation, France
2004/08/30 - 2004/09/10 Post-graduate Course - The course aims to prepare researchers for the appropriate use of animals in scientific experiments. This theoretical and practical course will cover the biology and husbandry of laboratory animals, aspects of microbiology and disease, health hazards and safe practices in the animal house, the design and conduct of animal experiments, anaesthesia, analgesia and experimental procedures, as well as the ethical and legal aspects of animal experimentation and alternatives to animal use.
Other
 Course on Laboratory Animal Science (FELASA – LEVEL C)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2003/06/25 - 2003/06/27 Short Course on Cell and Tissue Culture - The purpose of this short course is to improve the participants' knowledge of theoretical / practical aspects related to cell and tissue culture.
Other
 Cell and Tissue Culture
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2000/07/27 - 2000/08/01 Radiation Safety Course - In order to work with nuclear substances, individuals must have completed the Radiation Safety Course offered by EHS. EHS trains users and issues Radionuclide Permits under the Canadian Nuclear Safety Commission (CNSC) Licence issued to the University of Alberta.
Other
 Radiation Safety Course.
University of Alberta, Canada
2000/07/13 - 2000/07/14 The Care and Use of the Laboratory Mouse. Mandatory training course for animal users at the University of Alberta, Edmonton, Canada.
Other
 The Care and Use of the Laboratory Mouse
University of Alberta Health Sciences Laboratory Animal Services, Canada
1999/07/05 - 1999/07/09 Cytokines
Workshop
 Cytokines
Instituto Gulbenkian de Ciência, Portugal
1999/06/24 - 1999/07/05 Targeting of Drugs: Strategies for Gene Constructs and Deliver - This workshop deals with developments in circumventing the problems of direct DNA administration by the use of viral or non-viral vectors. Representatives from both camps of therapy discuss the challenges and opportunities of the two approaches and present the latest progress with a variety of constructs (viral and non-viral).
Workshop
 Targeting of Drugs: Strategies for Gene Constructs and Delivery
NATO, Belgium
1997/06/24 - 1997/07/05 Targeting of Drugs: Strategies for Stealth Therapeutic Systems - This workshop discusses in great depth the present and the future of the very importante research field of drug delivery. In particular, deals with a variety of approaches to evade the reticuloendothelial system and thus extend the circulation time of a variety of delivery systems including polymers, biopolymers, liposomes, and other nanoparticles or microparticles.
Workshop
 Targeting of Drugs: Strategies for Stealth Therapeutic Systems
NATO, Belgium
1995/09/14 - 1995/09/19 Short Course on: Liposome Technology - Clinical and Industrial Applications.
Workshop
 Liposome Technology - Clinical and Industrial Applications
Instituto Nacional de Engenharia e Tecnologia Industrial, Portugal
1993/10/11 - 1993/10/13 Yeast in Foods, Beverages & other products - A specialist course aimed at problem solving.
Workshop
 Yeast in Foods, Beverages & other products - A specialist course aimed at problem solving.
CABI, United Kingdom

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/11/22 Evaluation of Microneedle Arrays as potential delivery systems for bacterial extracellular vesicles
(Thesis) Arguer
 Miriam Domingos de Sousa (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/11/24 Innovative sporopollenin microgranules delivery system with photoprotective activity
(Thesis) Arguer
 Isabel Tomás Roça (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/11/22 New Insights in Permeability Studies: Bioprinted 3D Skin Models vs Biological Skin
(Thesis) Arguer
 Ana Filipa Vinhas Agostinho Matos (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/09/29 Nanoencapsulation of New Compounds with Potential Antileishmanial Activity
(Thesis) Arguer
 Jõao Pedro Vitorino Quintas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 Estudo do direcionamento ativo de nanossistemas lipídicos com antagonista G para células de cancro de pulmão
(Thesis) Main arguer
 Ana Margarida Ferreira da Silva (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 Management of Skin Cancer by Agonist of 5-HTI A and Antagonist of 5-HT2A receptors
(Thesis) Arguer
 Ana Catarina da Silva Fernandes Saraiva de Menezes (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Association member

Society Organization name Role
2019 - Current Spanish Portuguese Local Chapter, controlled Release Society

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2018 - Current Curso Pós-Graduado de Atualização de Ciências em Animais de Laboratório – Categoria B (Pós-Graduação) Universidade de Lisboa Faculdade de Farmácia, Portugal

Mentoring / Tutoring

Topic Student name
2021/09/01 - 2023/03 Development and characterization of an innovative drug delivery platform targeting breast cancer brain metastases Joana Raquel Aniceto Romão
Distinctions

Award

2019 Prêmio Octavio Frias de Oliveira 2019 na categoria Inovação Tecnológica em Oncologia
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brazil