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Sara Granja (SG), is an invited assistant teacher at Escola Superior de Saúde do Politécnico do Porto since 2020 and affiliated research at ICVS/3Bs, University of Minho. SG is graduated in Pathological Cytological and Thanatology Anatomy concluded her master thesis in 2009 and her PhD in Health Sciences at the School of Medicine from the University of Minho in 2013 . Since 2017 SG was regent of 25 curricular Units and lectured a total of 36 curricular Units on the field of Pathological Cytological and Thanatology Anatomy or Laboratory Biomedical Sciences. Since 2022 SG is coordinator of CTeSP Thanatopraxy, Thanatoaesthetics and Dissection. During her scientific career SG is studying the role of Monocarboxylate transporters (MCTs) in solid tumors, where SG is giving significant contributions to the research field of oncobiology with special focus on the study of glycolytic metabolism on the tumor microenvironment. Besides ICVS, SG had the opportunity to work in two top leading groups in the area of tumor metabolism and inflammation, one led by Jacques Pouysségur (IRCAN, Nice) and other by Massimiliano Mazzone (VIB, Leuven). SG i have authored or co-authored 35 papers in international peer-reviewed international journals and 4 book chapters with an accumulated impact factor of 202.29, nearly 1097 citations and a h-index of 19. SG supervised 1 PhD student, 11 master's dissertations and 24 bachelors projects. SG is works in the area of Medical and Health Sciences with an emphasis on Medical Biotechnology, Oncobiology and Immunometabolism.
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Identification

Personal identification

Full name
Sara Granja

Citation names

  • Granja, Sara

Author identifiers

Ciência ID
C41F-02E4-065E
ORCID iD
0000-0001-8717-6751

Email addresses

  • GCS@ESS.IPP.PT (Professional)

Addresses

  • Rua Dr. António Bernardino de Almeida, 400, 4200 - 072, Porto, Porto, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Health Sciences
  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Proficiency (C2) Advanced (C1) Advanced (C1)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1)
French Elementary (A2) Elementary (A2) Intermediate (B1)
Education
Degree Classification
2019/11/04 - 2020/11/04
Concluded
 FlowJo training (Outros)
VIB-KULeuven Center for Cancer Biology, Belgium
2014/09/01 - 2015/09/01
Concluded
 MBA executive (Postgraduate Certificate)
Universidade Lusíada de Vila Nova de Famalicão, Portugal
 Aprovado
2009/09/01 - 2013/12/17
Concluded
 PhD in health science (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
"The role of monocarboxylate transporter in lung development and lung cancer" (THESIS/DISSERTATION)
 aprovado
2010
Concluded
 An Integrative Approach to Cell Analysis (Outros)
Major in Animal Cell and Tissue Culture: From Basic Principles to Advanced Techniques (Pós-Graduation course)
Universidade do Minho Escola de Medicina, Portugal
 Aprovado
2007/09/01 - 2009/12/21
Concluded
 Master in Molecular Genetics (Mestrado)
Universidade do Minho Escola de Ciências, Portugal
"The role of monocarboxylate transporters on embryonic development on two animal models: Rattus norvegicus e Gallus gallus" (THESIS/DISSERTATION)
 18
2009
Concluded
 Laboratory Animal Science ( FELASA category C) (Pós-Graduation course) (Outros)
Universidade do Minho Escola de Medicina, Portugal
 Aprovado
2003/09/01 - 2007/07/30
Concluded
 Anatomia Patológica Citológica e Tanatólógicas (Licence)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
 15
Affiliation

Science

Category
Host institution 		Employer
2024/01/01 - Current Researcher (Research) Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
2021/09/09 - 2023/12/31 Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho, Portugal
2017/04/01 - 2021/09/14 Postdoc (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/06/15 - 2019/12/01 Postdoc (Research) VIB-KULeuven Center for Cancer Biology, Belgium
VIB-KULeuven Center for Cancer Biology, Belgium
2015/07 - 2017/03/30 Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014/04/01 - 2015/06/30 Postdoc (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010/01/01 - 2013/12/30 Researcher (Research) Universidade do Minho Escola de Medicina, Portugal
2011/11/01 - 2013/06/30 Researcher (Research) Institute for Research on Cancer and Aging, France

Teaching in Higher Education

Category
Host institution 		Employer
2023/12/04 - Current Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2020/09/18 - 2023/12/03 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2018/10/18 - 2019/07/18 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal
2017/09/18 - 2018/09/17 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal

Others

Category
Host institution 		Employer
2006/05/01 - 2006/06/14 Internship CGC Genetics Centro de Genética Clínica, Portugal
2005/09/01 - 2006/04/09 Internship Centro Hospitalar e Universitário de Coimbra EPE, Portugal
Projects

Grant

Designation Funders
2021/03/25 - 2023/03/31 Janus Approach to Cancer Theranostics (JUSThera)
NORTE-01-0145-FEDER-000055
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Agência Nacional de Inovação SA
Ongoing
2018/01/01 - 2021/12/31 Local specific treatment of triple-negative-breast-cancer through externally triggered target-less drug carriers-TMagTargetON
PTDC/BTM-SAL/31142/2017
International Iberian Nanotechnology Laboratory, Portugal

Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021 Macrophage-secreted mediators as therapeutic strategy for preterm lung maturation
POCI-01-0145-FEDER-028113
Researcher
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021 Local specific treatment of triple-negative-breast-cancer through externally triggered target-less drug carriers.
NORTE-01-0145-FEDER-031142
Researcher
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/04/01 - 2020/03/31 Cancer cell-macrophage metabolic symbiosis: unravelling the role of monocarboxylate transporters (MCTs)
SFRH/BPD/117858/2016
Post-doc Fellow
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2019 TAMs-targeted controlled nanotheranostics to improve triple-negative-breast-cancer prognosis
NANOTHER -UTAP-EXPL/NTec/0038/2017
Researcher
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/03/05 - 2018/09/06 Tears 4 life - A biosensor for the early detection of brain cancers
Tears 4 life
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

International Iberian Nanotechnology Laboratory, Portugal
Concluded
2014/04/01 - 2015/06/30 Creation of large animal models to test the concepts of no scar, no radiation exposure approaches for minimally invasive surgery in the oncological field
NORTE-07-0124-FEDER-000017
Post-doc Fellow
Laboratório Associado ICVS 3B's, Portugal
Concluded
2010/01/01 - 2013/12/30 Role of monocarboxylate transporters in lung development and lung cancer
SFRH/BD/51062/2010
PhD Student Fellow
Universidade do Minho Escola de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 ICVS/3B¿s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos
LA/P/0050/2020
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/26 - 2022/07/25 Os mediadores secretados por macrófagos como nova estratégia terapêutica para a maturação pulmonar em prematuros
PTDC/MED-FSL/28113/2017
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/07/02 - 2021/12/31 Tratamento local específico de cancro da mama triplo negativo por meio de fármacos pouco especificos externamente ativados
PTDC/BTM-SAL/31142/2017
International Iberian Nanotechnology Laboratory, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 ICVS/3B¿s - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group
UID/Multi/50026/2019
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 26 - 2011-2012
PEst-C/SAU/LA0026/2011
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Granja, Sara; Afonso, Julieta; Queirós, Odília; Tavares-Valente, Diana; Baltazar, Fatima. "New horizons on pH regulators as cancer biomarkers and targets for pharmacological intervention". In AN INNOVATIVE APPROACH TO UNDERSTANDING AND TREATING CANCER: TARGETING pH From Etiopathogenesis to New Therapeutic Avenues, 417-437. Elsevier, 2020.
    Accepted
  2. Pereira-Nunes, Andreia; Afonso, Julieta; Granja, Sara; Baltazar, Fátima. "Lactate and Lactate Transporters as Key Players in the Maintenance of the Warburg Effect". In Advances in Experimental Medicine and Biology, 51-74. Springer International Publishing, 2020.
    Published • 10.1007/978-3-030-34025-4_3
  3. Pereira-Nunes, Andreia; Afonso, Julieta; Granja, Sara; Baltazar, Fátima. "Lactate and lactate transporters as a key players in the maintenance of Warburg effect". In Tumor Microenvironment - The Main Driver of Metabolic Adaptation, edited by Serpa, Jacinta. Switzerland: Springer Nature, 2020.
    Published • 10.1007/978-3-030-34025-4
  4. Pinheiro, Céline; Granja, Sara; Morais-Santos, Filipa; Vera Miranda-Gonçalves; Afonso, Julieta; Amorim, Ricardo; Baltazar, Fátima. "Targeting Metabolic Reprogramming as an Anti- Cancer Strategy: Aiming at Monocarboxylate Transporters". In Frontiers in Anti-Cancer Drug Discovery, 3-65. BENTHAM SCIENCE PUBLISHERS, 2015.
    10.2174/9781681081496115060003
  5. Granja, Sara; Marchiq, Ibtissam; Baltazar, Fátima; Pouysségur, Jacques. "Gene Disruption Using Zinc Finger Nuclease Technology". In Methods in Molecular Biology, 253-260. Springer New York, 2014.
    Published • 10.1007/978-1-4939-0856-1_17
Conference abstract
  1. Granja, Sara; Silva, Regina. "Molecular techniques for the Neonatal Screening of Spinal Muscular Atrophy". Paper presented in I Congresso BioMedLab., Porto, 2023.
    Published
  2. Granja, Sara. "Estudo da morfologia de tecidos sujeitos a embalsamamento por método de Thiel.". Paper presented in I Jornadas do CISA – Jovens com a Ciência, Porto, 2023.
    Published
  3. Oliveira, Catarina; Granja, Sara; Neves, Nuno M.; Reis, Rui L.; Baltazar, Fátima; Silva, Tiago H.; Martins, Albino. "Fucoidan impairs the formation of tubular-like structures in vitro and inhibits tumor growth in vivo.". Paper presented in TERMIS-EU 2019, Rhodes, 2019.
  4. Granja, Sara. "Metabolic Reprograming in Adrenocortical Tumors in Children: A Promising New Pathway in the Biology of This Disease.". Paper presented in 10th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology., 2018.
  5. Granja, Sara. "Inhibition of lactate export by genetic disruption of MCT/basigin complex sensitizes tumor cells to phenformin". Paper presented in 4th Annual Meeting of the International Society of Proton Dynamics in Cancer., Munique, 2014.
    Published
  6. Granja, Sara. "Exploitating of Monocarboxylate transporters as therapeutic targets in lung cancer.". Paper presented in ISOBM 2011: the 39th Meeting of the International Society of Oncology and Biomarkers, florence, 2011.
    Published
  7. Granja, Sara. "Analysis of raf kinase inhibitor protein (RKIP) expression as a prognostic marker for glioblastomas.". Paper presented in European Journal of Cancer Supplements, oslo, 2010.
    Published
Conference paper
  1. Campos, Priscila B.; Oliveira, Claudia P.; Stefano, Jose Tadeu; Chagas, Aline; Herman, Paulo; D'Albuquerque, Luiz C.; Alvares-da-Silva, Mario R.; et al. "Hepatocellular carcinoma in non-alchoolic steatohepatitis (NASH): Clinical, histopathological aspects and immunohistochemical of metabolic and proliferative related-markers". 2017.
    Published
  2. Borges-Pereira, C.; Liborio-Ramos, S.; Barbosa-Matos, C.; Ribeiro-Freitas, C.; Morais-Santos, F.; Antunes, C.; Longatto-Filho, A.; et al. "Tissue macrophages modulate alveolar epithelial and myofibroblast differentiation during fetal lung sacculation.". 2017.
  3. Martinho, O.; Silva-Oliveira, R.; Cury, F.; Martins Barbosa, A.; Granja, S.; Feijo Evangelista, A.; Marques, F.; et al. "HER RECEPTORS ARE IMPORTANT THERANOSTIC BIOMARKERS ON CERVICAL CANCER: BLOCKING GLUCOSE METABOLISM ENHANCES THE THERAPEUTIC EFFECT OF HER INHIBITORS". 2016.
  4. Zerbini, Maria; Pinheiro, Celine; Granja, Sara; Longatto, Adhemar; Faria, Andre M.; Fragoso, Maria C. V.; Lovisolo, Silvana M.; et al. "Metabolic Reprograming in Adrenocortical Tumors in Children: A Promising New Pathway in the Biology of This Disease". 2016.
  5. Marques, A.; Granja, S.; Ferreira, A.; Silva, A.; Vilaca, S.; Marques, H.; Baltazar, F.. "Increased expression of monocarboxylate transporters 1 and 4 and carbonic anhydrase IX in pancreatic ductal adenocarcinomas". 2015.
    10.1093/annonc/mdv233.39
  6. Rodrigues, P.L.; Granja, S.; Moreira, A.; Rodrigues, N.; Vilaça, J.L.. "Application to quantify fetal lung branching on rat explants". 2013.
  7. Rodrigues, P.L.; Granja, S.; Moreira, A.; Rodrigues, N.; Vilaça, J.L.. "Application to quantify fetal lung branching on rat explants". 2013.
  8. Granja, Sara; Rios, Elisabete; Moura, C.S.; Carneiro, Fátima; Baltazar, Fátima. "Poster14.12: Monocarboxylate transporters as therapeutic targets in lung cancer". 2011.
    Published • 10.1007/s13277-011-0240-z
  9. Martinho, O.; Jaraquemada, T.; Caiero, C.; Granja, S.; Honavar, M.; Costa, P.; Damasceno, M.; Lopes, J.M.; Reis, R.M.. "Abstract 78 Analysis of raf kinase inhibitor protein (RKIP) expression as a prognostic marker for glioblastomas". 2010.
    10.1016/s1359-6349(10)70887-9
Conference poster
  1. Costa, Marta; Cerqueira, Mónica; Silva, Ana; Pontes, Olívia; Oliveira-Pinto, Sofia; Carvalho, Luísa; Lopes, Diogo; et al. "Chromene-based molecules: privileged scaffold for oncology drug development". Paper presented in III ASPIC-ASEICA International Meeting - Cancer Immunology, Tumor Microenvironment and Metastasis, 2023.
  2. Carvalho, Luísa; Pedroso de Lima, Fábio; Cerqueira, Mónica; Silva, Ana; Pontes, Olívia; Oliveira-Pinto, Sofia; Guerreira, Sara; et al. Corresponding author: Costa, Marta. "Biological characterization of novel chromeno[2,3-d]pyrimidinones as therapeutic approach for the treatment of triple-negative Breast Cancer". Paper presented in III ASPIC-ASEICA International Meeting - Cancer Immunology, Tumor Microenvironment and Metastasis, 2023.
  3. Carvalho, Luísa; Pedroso de Lima, Fábio; Cerqueira, Mónica; Silva. Ana; Pontes, Olívia; Oliveira-Pinto, Sofia; Guerreiro, Sara; et al. Corresponding author: Costa, Marta. "In vitro and in vivo evaluation of novel chromeno[2,3-d]pyrimidinones as therapeutic agents for triple negative breast cancer". Paper presented in 5th National Meeting for Young Researchers in Oncology, 2023.
  4. Carvalho, Luísa; Pedroso de Lima, Fábio; Cerqueira, Mónica; Silva. Ana; Pontes, Olívia; Oliveira-Pinto, Sofia; Guerreiro, Sara; et al. Corresponding author: Costa, Marta. "Avaliação in vitro e in vivo de novos cromeno[2,3-d]pirimidinonas como agentes terapêuticos para o cancro da mama triplo-negativo". Paper presented in 5th National Meeting for Young Researchers in Oncology, 2023.
  5. Granja, Sara. "Estudo da morfologia de tecidos sujeitos a embalsamamento por método de Thiel". Paper presented in I Jornadas do CISA - Jovens com a Ciência, 2023.
  6. Granja, Sara; Silva, Regina A. "The role of CD147 in cancer immunosuppression.". Paper presented in XXIII Congresso Técnico de Anatomia Patológica, 2023.
  7. Martins, Eduarda P.; Gonçalves, Céline S.; Peixoto, Joana; Ferreira, Joana M.; Longatto-Filho, Adhemar; Lima, Jorge; Costa, Pedro M.; Granja, Sara; Costa, Bruno M.. "Unveiling the impact of the oncogenic molecule Cadherin-3 in the metabolism of human glioblastoma". Paper presented in XIII Portuguese Association of Neuro-Oncology National Congress, 2023.
  8. Abreu, Sara; Granja, Sara; Baltazar, Fátima. Corresponding author: Abreu, Sara. "Transportadores de monocarboxilatos (MCTs) e simbiose metabólica entre células tumorais e macrófagos". Paper presented in 4º Encontro Nacional de Jovens Investigadores em Oncologia, Liga Portuguesa Contra o Cancro, 2022.
  9. Abreu, Sara; Granja, Sara; Mazzone, Max; Sonveaux, Pierre; Baltazar, Fátima. Corresponding author: Abreu, Sara. "Monocarboxylate transporters (MCTs): key players in the metabolic symbiosis between tumour cells and macrophages". Paper presented in Recent insights into Immuno-Oncology, VIB, Leuven, Belgium, 2022.
  10. Ammarah, Ummi; Pereira-Nunes, Andreia; Shang, Min; Di Matteo, Mario; Granja, Sara; Baltazar, Fátima; Mazzone, Massimiliano. "Targeting macrophage GLUD1 inhibits metachronous and synchronous metastases. Recent insights into Immuno-Oncology". Paper presented in Recent insights into Immuno-Oncology, 2022.
  11. Pinheiro, Joana; Fontão, Patrícia; Gabriela-Freitas, Maria; Cardoso-Carneiro, Diana; Raquel-Cunha, Ana; Granja, Sara; Martinho, Olga. "Role of RKIP protein in the modulation of lung cancer cell metabolism". Paper presented in II ASPIC-ASEICA International Meeting ¿ Current Trends in Precision Medicine in Cancer, 2021.
  12. Abreu, Sara; Granja, Sara; Baltazar, Fátima. Corresponding author: Abreu, Sara. "Transportadores de monocarboxilatos (MCTs) e interação entre células tumorais e macrófagos". Paper presented in 3º Encontro Nacional de Jovens Investigadores em Oncologia, Liga Portuguesa Contra o Cancro, 2021.
  13. Pereira-Nunes, Andreia; Santos, Nuno; Baltazar, Fátima; Granja, Sara. "CD147 in cancer immunosurveillance: new-tool for T-cell based immunotherapy?". Paper presented in EACR 2021 Congress: "Innovative Cancer Science: Better Outcomes through Research", 2021.
  14. Vieira, Joana; Sónia Pires-Celeiro; Granja, Sara; Barbosa-Matos, Catarina; H Ko, Young ; Preto, Ana; Odília Queirós; Casal, Margarida; Baltazar, Fátima. "Targeting glycolytic metabolism as a therapeutic strategy for Acute Myeloid Leukemia". Paper presented in EACR 2021 Virtual Congress, 2021.
  15. Pereira-Nunes, Andreia; Santos, Nuno; Costa, Sandra; Baltazar, Fátima; Granja, Sara. "Lactate transporters as targets to improve immunotherapy". Paper presented in EACR-AACR-ASPIC 2020 Conference: Tumor Microenvironment, 2020.
  16. Granja, Sara. "Disruption of cancer cell metabolism using targeted drug delivery systems". Paper presented in LPCC, Virtual Conference,, 2020.
  17. Pinheiro, Joana; Gabriela-Freitas, Maria; Cardoso-Carneiro, Diana; Raquel-Cunha, Ana; Granja, Sara; Martinho, Olga. "Role of RKIP protein in the modulation of cancer cells metabolism in solid tumors". Paper presented in 6th meeting of ISCaM, 2019.
  18. Ferreira, Nathalia; Baltazar, Fátima; Granja, Sara; Granja, S.. "Elucidating the impact of IL-17A/F in lung cancer". Paper presented in 25th Porto Cancer meeting, 2018.
  19. Nunes, AP; Ferreira, H; Neves M Nuno; Baltazar, F; Granja, S.. "Targeting Cancer Cell Metabolism Using Targeted Drug Delivery Systems". Paper presented in 25th Porto Cancer meeting, 2018.
  20. Granja, Sara; Costa, Sandra; Baltazar F. "Cancer cell-macrophage metabolic symbiosis: unravelling the role of monocarboxylate transporters (MCTs)". Paper presented in FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2017.
  21. Granja, Sara; Borges -Pereira C; Liborio-Ramos, S.; Barbosa-Matos, C.; Ribeiro-Freitas, C.; Granja, S.; Correia-Pinto, Jorge; Costa, Sandra. "Tissue macrophages modulate alveolar epithelial and myofibroblast differentiation during fetal lung sacculation.". Paper presented in ASCB/EMBO 2017 Meeting Philadelphia, USA, 2017.
  22. Granja, Sara; João Azevedo-Silva ; Preto, Ana; Queirós, Odília; Baltazar, Fatima; Casal, Margarida. "Targeting glycolysis in acute myeloid leukemia: therapeutic applications". Paper presented in XIX National Congress of Biochemistry, 2016.
  23. Granja, Sara; Pinheiro, Celine; Longatto-Filho, A.; Almeida, Madson Q.; Faria, Andre M.; Fragoso, Maria C. V.; Lovisolo, Silvana M.; et al. "The Warburg effect: a new relevant road in the biology of adrenocortical tumors in adults". Paper presented in 2nd ISCaM meeting - Metabolism and Microenvironment in Cancer Plasticy, 2015.
  24. Granja, Sara; Marchiq I; Le Floch, R.; Moura, C.S.; Baltazar F; Pouysségur, Jacques. "Targeting CD147/Basigin sensitizes A549 lung carcinoma cells to Phenformin". Paper presented in 1st ASPIC International Congress, 2014.
  25. Granja, Sara; Marchiq, I.; Le Floch, R.; Roux D; Pouysségur, Jacques. "Inhibition of lactate export by genetic disruption of MCT/basigin complex sensitize tumor cells to phenformin". Paper presented in ISPDC 2013 Annual Meeting, 2013.
  26. Granja, Sara; Marchiq, I.; Le Floch Renaud; Baltazar, Fátima; Pouysségur, Jacques. "Targeting CD147/Basigin sensitizes A549 lung carcinoma cells to Phenformin". Paper presented in TAT meeting 2013, 2013.
  27. Granja, Sara; Marchiq I; Le Floch, R.; Roux D; Baltazar, Fátima; Pouysségur, Jacques. "Targeting CD147/Basigin sensitizes A549 lung carcinoma cells to Phenformin". Paper presented in Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment, 2013.
    10.1109/bmei.2011.6098510
  28. Granja, Sara; Marchiq, I.; Le Floch, R.; Roux D; Pouysségur, Jacques. "Genetic disruption of CD147/ Basigin, a subunit of lactate-H+ Symporters (MCTs), sensitizes glycolytic tumour cells to Phenformin". Paper presented in EMBO meeting 2012, 2012.
  29. Granja, Sara; Marchiq, Ibtissam; Le Floch Renaud; Baltazar, Fátima; Pouysségur, Jacques. "Targeting CD147/Basigin in A549 lung carcinoma sensitizes these cells to Metformin". Paper presented in XXI Porto Cancer Meeting, 2012.
  30. Granja, Sara; Rios, Elisabete; Moura, C.S.; Carneiro, Fátima; Baltazar, Fátima. "Monocarboxylate transporters as therapeutic targets in lung cancer". Paper presented in 39th meeting of ISOBM, 2011.
  31. Granja, Sara; Rios, Elisabete; Moura, C.S.; Carneiro, Fátima; Baltazar, Fátima. "Monocarboxylate transporters as therapeutic targets in lung cancer". Paper presented in ISPDC 2011 Annual Meeting, 2011.
  32. Granja, Sara; Rios, Elisabete; Moura, C.S.; Carneiro, Fátima; Baltazar, Fatima. "The role of Monocarboxylate transporters in lung cancer". Paper presented in XX Porto Cancer Meeting, 2011.
  33. Martinho, Olga; Granja, Sara; Jaraquemada, Teresa; Caeiro, Cláudia; Honavar, Mrinalini; Paulo Costa; Damasceno, Margarida; Lopes, José M.; Reis, Rui M.. "Raf kinase inhibitor protein (RKIP) expression as a prognostic marker for gliomas". Paper presented in XIX Porto Cancer Meeting, 2010.
    10.1109/indico.2004.1497783
  34. Granja, Sara; Ana Paula António; Paula Agapito; Madalena Dinis. "A acuidade de diagnóstico: Esfregaço Convencional VS Método de Papspin". Paper presented in XIV Reunião da Sociedade portuguesa de Citologia e XVII Congreso Nacional de la Sociedad Española de Citologia, 2006.
Journal article
  1. Pereira-Vieira, Joana; Weber, Daniela D.; Silva, Sâmia; Catarina Barbosa-Matos; Granja, Sara; Reis, Rui Manuel; Queirós, Odília; et al. "Glucose Metabolism as a Potential Therapeutic Target in Cytarabine-Resistant Acute Myeloid Leukemia". Pharmaceutics 16 4 (2024): 442. http://dx.doi.org/10.3390/pharmaceutics16040442.
    Published • 10.3390/pharmaceutics16040442
  2. Abreu, Sara; Martins, Eduarda P.; Granja, Sara; Costa, Bruno M.. "Metabolic symbioses between glioblastoma and immune cells: a special focus on microglia and macrophages". (2024):
    Submitted
  3. Martins, Eduarda P.; Gonçalves, Céline S.; Peixoto, Joana; Ferreira, Joana M.; Longatto-Filho, Adhemar; Costa, Pedro M.; Osório, Nuno S.; Granja, Sara; Costa, Bruno M.. "A transcriptomic profiling reveals novel roles of Cadherin-3 in metabolic programming of glioblastoma". (2024):
    Submitted
  4. Abreu, Sara; Silva, Margarida; Costa, Sara; Baltazar, Fátima; Granja, Sara. Corresponding author: Granja, Sara. "Targeting lactate in innate immune system to treat cancer - in final phase of preparation". (2024):
  5. Pereira-Nunes, Andreia; Ferreira, Helena; Abreu, Sara; Guedes, Marta; Neves, Nuno M.; Baltazar, Fátima; Granja, Sara. Corresponding author: Granja, Sara. "Combination Therapy With CD147-Targeted Nanoparticles Carrying Phenformin Decreases Lung Cancer Growth". Advanced Biology 7 7 (2023): http://dx.doi.org/10.1002/adbi.202300080.
    10.1002/adbi.202300080
  6. Luísa Carvalho; Pedroso de Lima, Fábio; Pontes, Olívia; Oliveira-Pinto, Sofia; Cerqueira, Mónica; Ana silva; Guerreiro, Sara R.; et al. "Synthesis and Biological Evaluation of Novel Chromeno[2,3-d]Pyrimidinones as Agents for Triple Negative Breast Cancer Treatment". RSC Medicinal Chemistry (2023):
    Under revision
  7. Ferreira, João C. C.; Granja, Sara; Almeida, Ana F.; Baltazar, Fátima; Gonçalves, M. Sameiro T.; Preto, Ana; Sousa, Maria João. "Targeting Lysosomes in Colorectal Cancer: Exploring the Anticancer Activity of a New Benzo[a]phenoxazine Derivative". International Journal of Molecular Sciences 24 1 (2022): 614. http://dx.doi.org/10.3390/ijms24010614.
    10.3390/ijms24010614
  8. Granja, Sara; Longatto-Filho, Adhemar; de Campos, Priscila B.; Oliveira, Claudia P.; Stefano, José T.; Martins-Filho, Sebastião N.; Chagas, Aline L.; et al. "Non-Alcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma: Immunohistochemical Assessment of Markers of Cancer Cell Metabolism". Pathobiology 89 3 (2022): 157-165. http://dx.doi.org/10.1159/000521034.
    10.1159/000521034
  9. Carvalho, Luísa; Fábio Pedroso de Lima; Pontes, Olívia; Oliveira-Pinto, Sofia; Granja, Sara; Maciel, Patrícia; Longatto, Adhemar; et al. "New chromene-based compounds as anticancer agents for triple-negative breast cancer therapy". Euroepan Journal of Medicinal Chemistry (2022):
    Submitted
  10. Miranda-Gonçalves, Vera; Gonçalves, Céline S.; Granja, Sara; Vieira de Castro, Joana; Reis, Rui M.; Costa, Bruno M.; Baltazar, Fátima. "MCT1 Is a New Prognostic Biomarker and Its Therapeutic Inhibition Boosts Response to Temozolomide in Human Glioblastoma". Cancers 13 14 (2021): 3468. http://dx.doi.org/10.3390/cancers13143468.
    10.3390/cancers13143468
  11. Ferreira, Natália N.; de Oliveira Junior, Edilson; Granja, Sara; Boni, Fernanda I.; Ferreira, Leonardo M.B.; Cury, Beatriz S.F.; Santos, Lilian C.R.; et al. "Nose-to-brain co-delivery of drugs for glioblastoma treatment using nanostructured system". International Journal of Pharmaceutics 603 (2021): 120714. http://dx.doi.org/10.1016/j.ijpharm.2021.120714.
    10.1016/j.ijpharm.2021.120714
  12. Morais, Mariana; Dias, Francisca; Nogueira, Inês; Leão, Anabela; Gonçalves, Nuno; Araújo, Luís; Granja, Sara; et al. "Cancer Cells’ Metabolism Dynamics in Renal Cell Carcinoma Patients’ Outcome: Influence of GLUT-1-Related hsa-miR-144 and hsa-miR-186". Cancers 13 7 (2021): 1733. http://dx.doi.org/10.3390/cancers13071733.
    10.3390/cancers13071733
  13. Vilaça, Natália; Bertão, Ana Raquel; Prasetyanto, Eko Adi; Granja, Sara; Costa, Marta; Fernandes, Rui; Figueiredo, Francisco; et al. "Surface functionalization of zeolite-based drug delivery systems enhances their antitumoral activity in vivo". Materials Science and Engineering: C 120 (2021): 111721. http://dx.doi.org/10.1016/j.msec.2020.111721.
    10.1016/j.msec.2020.111721
  14. Natália N. Ferreira; Sara Granja; Fernanda I. Boni; Fabíola G. Prezotti; Leonardo M. B. Ferreira; Beatriz S. F. Cury; Rui M. Reis; Fátima Baltazar; Maria Palmira D. Gremião. "Modulating chitosan-PLGA nanoparticle properties to design a co-delivery platform for glioblastoma therapy intended for nose-to-brain route". Drug Delivery and Translational Research 10 6 (2020): 1729-1747. https://doi.org/10.1007/s13346-020-00824-2.
    10.1007/s13346-020-00824-2
  15. Pereira-Nunes, Andreia; Simões-Sousa, Susana; Pinheiro, Céline; Miranda-Gonçalves, Vera; Granja, Sara; Baltazar, Fátima. "Targeting lactate production and efflux in prostate cancer". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 11 (2020): 165894. http://dx.doi.org/10.1016/j.bbadis.2020.165894.
    10.1016/j.bbadis.2020.165894
  16. Nathalia Ferreira; Inês Mesquita; Fátima Baltazar; Ricardo Silvestre; Sara Granja. "IL-17A and IL-17F orchestrate macrophages to promote lung cancer". Cellular Oncology 43 4 (2020): 643-654. https://doi.org/10.1007/s13402-020-00510-y.
    Published • 10.1007/s13402-020-00510-y
  17. Rocha, Luís A.; Gomes, Eduardo D.; Afonso, João L.; Granja, Sara; Baltazar, Fatima; Silva, Nuno A.; Shoichet, Molly S.; et al. "In vitro Evaluation of ASCs and HUVECs Co-cultures in 3D Biodegradable Hydrogels on Neurite Outgrowth and Vascular Organization". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.00489.
    10.3389/fcell.2020.00489
  18. Baltazar, Fátima; Afonso, Julieta; Costa, Marta; Granja, Sara. "Lactate Beyond a Waste Metabolite: Metabolic Affairs and Signaling in Malignancy". Frontiers in Oncology 10 (2020): http://dx.doi.org/10.3389/fonc.2020.00231.
    10.3389/fonc.2020.00231
  19. Ferreira, Natália N.; Granja, Sara; Boni, Fernanda Isadora; Ferreira, Leonardo M. B.; Reis, Rui M.; Baltazar, Fátima; Gremião, Maria Palmira D.. "A novel strategy for glioblastoma treatment combining alpha-cyano-4-hydroxycinnamic acid with cetuximab using nanotechnology-based delivery systems". Drug Delivery and Translational Research (2020): http://dx.doi.org/10.1007/s13346-020-00713-8.
    Published • 10.1007/s13346-020-00713-8
  20. Riera-Domingo, Carla; Audigé, Annette; Granja, Sara; Cheng, Wan-Chen; Ho, Ping-Chih; Baltazar, Fátima; Stockmann, Christian; Mazzone, Massimiliano. "Immunity, Hypoxia and Metabolism - the ménage à trois of cancer: implications for immunotherapy". Physiological Reviews (2020): http://dx.doi.org/10.1152/physrev.00018.2019.
    Published • 10.1152/physrev.00018.2019
  21. Oliveira C; Granja S; Neves NM; Reis RL; Baltazar F; Silva TH; Martins A. "Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo". Carbohydrate polymers. (2019): http://europepmc.org/abstract/AGR/IND606494786.
  22. Ferreira, Débora; Silva, Ana P.; Nobrega, Franklin L.; Martins, Ivone M.; Barbosa-Matos, Catarina; Granja, Sara; Martins, Sandra F.; Baltazar, Fátima; Rodrigues, Ligia R.. "Rational Identification of a Colorectal Cancer Targeting Peptide through Phage Display". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-40562-1.
    10.1038/s41598-019-40562-1
  23. Santos, Nuno; Pereira-Nunes, Andreia; Baltazar, Fátima; Granja, Sara. "Lactate as a Regulator of Cancer Inflammation and Immunity". Immunometabolism (2019): http://dx.doi.org/10.20900/immunometab20190015.
    10.20900/immunometab20190015
  24. Tavares-Valente, Diana; Granja, Sara; Baltazar, Fátima; Queirós, Odília. "Bioenergetic modulators hamper cancer cell viability and enhance response to chemotherapy". Journal of Cellular and Molecular Medicine 22 8 (2018): 3782-3794. http://dx.doi.org/10.1111/jcmm.13642 IF=4,302.
    Accepted • 10.1111/jcmm.13642
  25. Miranda-Gonçalves, Vera; Cardoso-Carneiro, Diana; Valbom, Inês; Cury, Fernanda Paula; Silva, Viviane Aline; Granja, Sara; Reis, Rui M.; Baltazar, Fátima; Martinho, Olga. "Metabolic alterations underlying Bevacizumab therapy in glioblastoma cells". Oncotarget 8 61 (2017): http://dx.doi.org/10.18632/oncotarget.21761 IF=5,168.
    10.18632/oncotarget.21761
  26. Vieira de Castro, Joana*; Gomes, Eduardo D.*; Granja, Sara; Anjo, Sandra I.; Baltazar, Fátima; Manadas, Bruno; Salgado, António J.; Costa, Bruno M.. "Impact of mesenchymal stem cells’ secretome on glioblastoma pathophysiology". Journal of Translational Medicine 15 1 (2017): http://dx.doi.org/10.1186/s12967-017-1303-8 IF=4,197.
    10.1186/s12967-017-1303-8
  27. Granja, Sara; Tavares-Valente, Diana; Queirós, Odília; Baltazar, Fátima. "Value of pH regulators in the diagnosis, prognosis and treatment of cancer". Seminars in Cancer Biology 43 (2017): 17-34. http://dx.doi.org/10.1016/j.semcancer.2016.12.003 IF=10,198.
    10.1016/j.semcancer.2016.12.003
  28. Martinho, Olga; Silva-Oliveira, Renato; Cury, Fernanda P.; Barbosa, Ana Martins; Granja, Sara; Evangelista, Adriane Feijó; Marques, Fábio; et al. "HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors". Theranostics 7 3 (2017): 717-732. http://dx.doi.org/10.7150/thno.17154 IF=8,537.
    10.7150/thno.17154
  29. Pinheiro, C.*; Granja, S.; Longatto-Filho, A.; Faria, A.M.; Fragoso, M.C.B.V.; Lovisolo, S.M.; Bonatelli, M.; et al. "GLUT1 expression in pediatric adrenocortical tumors: A promising candidate to predict clinical behavior". Oncotarget 8 38 (2017): 63835-63845. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029795275&partnerID=MN8TOARS IF=5,168.
    Accepted • 10.18632/oncotarget.19135
  30. Rossi, Esther Diana; Bizzarro, Tommaso; Granja, Sara; Martini, Maurizio; Capodimonti, Sara; Luca, Emilia; Fadda, Guido; et al. "The expression of monocarboxylate transporters in thyroid carcinoma can be associated with the morphological features of BRAF V600E mutation". Endocrine 56 2 (2016): 379-387. http://dx.doi.org/10.1007/s12020-016-1044-0 IF=3,131.
    10.1007/s12020-016-1044-0
  31. Simões-Sousa, S.*; Granja, S.*; Pinheiro, C.; Fernandes, D.; Longatto-Filho, A.; Laus, A.C.; Alves, C.D.C.; et al. "Prognostic significance of monocarboxylate transporter expression in oral cavity tumors". Cell Cycle 15 14 (2016): 1865-1873. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976299772&partnerID=MN8TOARS IF=3,53.
    10.1080/15384101.2016.1188239
  32. Miranda-Gonçalves, V.; Granja, S.; Martinho, O.; Honavar, M.; Pojo, M.; Costa, B.M.; Pires, M.M.; et al. "Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas". Oncotarget 7 29 (2016): 46335-46353. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979950555&partnerID=MN8TOARS IF=5,168.
    10.18632/oncotarget.10114
  33. Morais-Santos F; Granja S; Miranda-Gonçalves V; Moreira AH; Queirós S; Vilaça JL; Schmitt FC; et al. "Targeting lactate transport suppresses in vivo breast tumour growth.". Oncotarget (2015): http://europepmc.org/abstract/med/26203664 IF=5.
  34. Pinheiro, C.*; Granja, S.; Longatto-Filho, A.; Faria, A.M.; Fragoso, M.; Lovisolo, S.M.; Lerário, A.; et al. "Metabolic reprogramming: A new relevant pathway in adult adrenocortical tumors". Oncotarget 6 42 (2015): 44403-44421. http://www.scopus.com/inward/record.url?eid=2-s2.0-84953410803&partnerID=MN8TOARS IF=5.
    10.18632/oncotarget.5623
  35. Granja, S.; Marchiq, I.; Le Floch, R.; Moura, C.S.; Baltazar, F.; Pouysségur, J.; Granja S; et al. "Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status". Oncotarget 6 9 (2015): 6708-6721. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927127315&partnerID=MN8TOARS IF=5.
    10.18632/oncotarget.2862
  36. Granja, S.; Pinheiro, C.; Reis, R.M.; Martinho, O.; Baltazar, F.. "Glucose addiction in cancer therapy: Advances and drawbacks". Current Drug Metabolism 16 3 (2015): 221-242. IF=2,847.
    10.2174/1389200216666150602145145
  37. Marchiq, I.; Albrengues, J.; Granja, S.; Gaggioli, C.; Pouysségur, J.; Simon, M.-P.. "Knock out of the BASIGIN/CD147 chaperone of lactate/H+symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction". Oncotarget 6 28 (2015): 24636-24648. IF=5.
    10.18632/oncotarget.4323
  38. Morais-Santos, F.; Granja, S.; Miranda-Gonçalves, V.; Moreira, A.H.J.; Queirós, S.; Vilaça, J.L.; Schmitt, F.C.; et al. "Targeting lactate transport suppresses in vivo breast tumour growth". Oncotarget 6 22 (2015): 19177-19189. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938895687&partnerID=MN8TOARS.
  39. Morais-Santos, F.; Granja, S.; Miranda-Gon?alves, V.; Moreira, A.H.J.; Queirós, S.; Vila?a, J.L.; Schmitt, F.C.; et al. "Targeting lactate transport suppresses in vivo breast tumour growth". Oncotarget 6 22 (2015): 19177-19189. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359360000038&KeyUID=WOS:000359360000038.
    10.18632/oncotarget.3910
  40. Rodrigues PL; Rodrigues NF; Duque D; Granja S; Correia-Pinto J; Vilaça JL. "Automated Image Analysis of Lung Branching Morphogenesis from Microscopic Images of Fetal Rat Explants.". (2014): http://europepmc.org/abstract/PMC/PMC4163400.
  41. Rodrigues, P.L.; Rodrigues, N.F.; Duque, D.; Granja, S.; Correia-Pinto, J.; Vilaça, J.L.. "Automated image analysis of lung branching morphogenesis from microscopic images of fetal rat explants". Computational and mathematical methods in medicine 2014 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84929297574&partnerID=MN8TOARS.
    10.1155/2014/820214
  42. Rodrigues PL; Rodrigues NF; Duque D; Granja S; Correia-Pinto J; Vilaça JL. "Automated Image Analysis of Lung Branching Morphogenesis from Microscopic Images of Fetal Rat Explants.". (2014): http://europepmc.org/abstract/med/25250057.
  43. Granja, Sara. "The monocarboxylate transporter inhibitor a-cyano-4-hydroxycinnamic acid disrupts rat lung branching.". Cell Physiol Biochem. (2013):
  44. Martinho, O.; Pinto, F.; Granja, S.; Miranda-Gonçalves, V.; Moreira, M.A.R.; Ribeiro, L.F.J.; di Loreto, C.; et al. "RKIP Inhibition in Cervical Cancer Is Associated with Higher Tumor Aggressive Behavior and Resistance to Cisplatin Therapy". PLoS ONE 8 3 (2013): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000317562100076&KeyUID=WOS:000317562100076 IF=4.73.
    Published • 10.1371/journal.pone.0059104
  45. Granja, S.; Morais-Santos, F.; Miranda-Gonçalves, V.; Viana-Ferreira, M.; Nogueira, R.; Nogueira-Silva, C.; Correia-Pinto, J.; Baltazar, F.. "The monocarboxylate transporter inhibitor a-cyano-4-hydroxycinnamic acid disrupts rat lung branching". Cellular Physiology and Biochemistry 32 6 (2013): 1845-1856. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890530426&partnerID=MN8TOARS IF=3.55.
    Published • 10.1159/000356617
  46. Martinho, Olga; Granja, Sara; Jaraquemada, Teresa; Caeiro, Cláudia; Miranda-Gonçalves, Vera; Honavar, Mrinalini; Costa, Paulo; et al. "Downregulation of RKIP Is Associated with Poor Outcome and Malignant Progression in Gliomas". PLoS ONE 7 1 (2012): e30769. http://dx.doi.org/10.1371/journal.pone.0030769 IF=3.730.
    10.1371/journal.pone.0030769
Thesis / Dissertation
  1. Granja, Sara Costa. "Role of Monocarboxylate transporter in lung development and lung cancer". PhD, 2013. http://hdl.handle.net/1822/28874.

Other

Other output
  1. Automated image analysis of lung branching morphogenesis. Regulating mechanisms of branchingmorphogenesis of fetal lung rat explants have been an essential tool formolecular research.This work presents a new methodology to accurately quantify the epithelial, outer contour, and peripheral airway buds of lung explants during cellular development frommicroscopic images. Methods.Theouter contour was defined using an adaptive and multiscale threshold algorith. 2014. Rodrigues, Pedro L.; F. Rodrigues, Nuno; Duque, Duarte; Granja, Sara; Correia-Pinto, Jorge; Vilaça, João L.. http://hdl.handle.net/11110/807.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/04/28 Monocarboxylate transporters (MCTs) as key players in the metabolic symbiosis between cancer cells and macrophages. CCC-TRIO 2023, Translational Oncology & Immuno-Onco
2023/01/25 Altered Metabolism in Cancer Curso Avançado de Oncobiologia IUCS-CESPU
2022/05/26 Targeting Monocarboxylate transporters to trigger anti-tumor immunity Immunometabolism: From basics to therapy
2020/12/01 Inibição do Metabolismo tumoral como tratamento do cancro do pulmão Webinar “Aplicações da Biotecnologia na área da Saúde”, 8as jornadas de ciências biotecnológicas
2017/04 Alvos terapêuticos em oncobiologia – Mesa Redonda X Encontro Nacional de Estudantes de Bioquimica
Associação de Estudantes de Bioquímica (Portugal) (Braga, Portugal)
2015/04 Energetic metabolism as therapeutic Target in cancer Semana das Ciencias e Tecnologia
(Evora, Portugal)
2015/03/13 Inibição do complexo CD147/MCTs sensibiliza células tumorais de pulmão à fenformina V Simposio Tecnico de Anatomia Patológica
(Porto, Portugal)
2010/03 The role of Monocarboxylate transporters during embryonic development of Gallus gallus III Simposio Tecnico de Anatomia Patológica
(Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/09 - Current Targeting CD147 in lung cancer to improve immunotherapy
Supervisor
 Mestrado em Bioquímica em Saúde (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2022/09/03 - 2023/11/20 Fatores pré-analíticos que influenciam a Sequenciação de Nova Geração (NGS): Experiência IPO Coimbra
Co-supervisor
 Técnicas Laboratoriais em Biopatologia (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2022/09/04 - 2023/11/10 Concordância mutacional em casos de Cancro Colorretal Síncronos
Co-supervisor
 Técnicas Laboratoriais em Biopatologia (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2019/09 - 2023/09 CD147 in cancer immunosurveillance: new tool for T-cell based immunotherapy?
Supervisor
 PhD in health sciences (PhD)
Universidade do Minho Escola de Medicina, Portugal
2021/09/04 - 2022/11/30 The role of CD147 in lung cancer immunosurveillance
Supervisor
 Bioquímica em Saúde (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2021/09/03 - 2022/11/29 The role of GPR81 in lung cancer
Supervisor
 Bioquímica em Saúde (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2021/09/06 - 2022/11/28 Implementation of molecular techniques for the neonatal sreening of spinal muscular atrophy
Co-supervisor
 Mestrado em Técnicas Laboratoriais em Biopatologia (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2021/09/03 - 2022/11/27 Transcripts as modifiers of phenotypic variability in hereditary transthyretin-mediated amyloidosis biopsies
Co-supervisor
 Técnicas Laboratoriais em Biopatologia (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2021/07/04 - 2022/11/20 Monocarboxylate transporters (MCTs): key players in the metabolic symbiosis between tumour cells and macrophages
Supervisor
 Ciências da Saúde (Master)
Universidade do Minho, Portugal
2020/09 - 2022/11 Doença Trofoblástica Gestacional
Co-supervisor
 Técnicas Laboratoriais em Biopatologia (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2021/09/01 - 2022/09/01 Targeting MCT1 in Tumor-associated macrophages
Supervisor
 Mestrado em ciências da saúde (Master)
Universidade do Minho Escola de Medicina, Portugal
2021/07 - 2022/01 Lactate shuttle between cancer cells and tumor associated macrophages
Supervisor
Universidade do Minho Escola de Medicina, Portugal
2020/09 - 2021/11 Estudo de como DAD, SMAD inibitória em Drosophila Melanogaster, regula a via da TGFß durante o desenvolvimento
Co-supervisor
 Técnicas Laboratoriais em Biopatologia (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2021/04 - 2021/06 Unravel the role of lactate receptor GPR81 in lung cancer
Supervisor
 Bioquímica (Degree)
Universidade do Minho, Portugal
2020/06 - 2021/03 Role of RKIP protein in the modulation of lung cancer cell metabolism
Co-supervisor
 Mestrado em Ciências da Saúde (Master)
Universidade do Minho Escola de Medicina, Portugal
2018/09/01 - 2019/12/20 Targeting lactate transport for tumor immunotherapy
Supervisor
 Mestrado em Ciências da Saúde (Master)
Universidade do Minho Escola de Medicina, Portugal
2017/09/01 - 2018/10/29 Targeting cancer cell metabolism using targeted drug delivery systems
Supervisor
 Mestrado Ciencias da Saude (Master)
Universidade do Minho Escola de Medicina, Portugal
2017/09/01 - 2018/10/16 Elucidating the impact of IL-17A/F in lung cancer
Supervisor
 Mestrado em Ciencias da Saude (Master)
Universidade do Minho Escola de Medicina, Portugal
2016/07 - 2017/01 SPINT-2 expression in lung cance
Co-supervisor
Universidade do Minho Escola de Medicina, Portugal
2016/06 - 2017/01 The role of monocarboxylate transporters in AML
Co-supervisor
Universidade do Minho Escola de Medicina, Portugal
2017 - 2017 Transportadores de Monocarboxilatos (MCTs) como alvos terapêuticos em tumores sólidos
Supervisor
 Bioquímica (Degree)
Universidade do Minho, Portugal
2017 - 2017 LACTATO COMO MOLÉCULA SINALIZADORA NA SIMBIOSE METABÓLICA ENTRE CÉLULAS TUMORAIS E MACRÓFAGOS ASSOCIADOS AO TUMOR Bioquímica (Degree)
Universidade do Minho, Portugal
2014/07 - 2015/01 Evaluation of expression and clinicopathological relevance of metabolism- related proteins in head and neck cancer
Co-supervisor
Universidade do Minho Escola de Medicina, Portugal
2014 - 2014 The metabolic interaction between macrophages and cervical cancer
Supervisor
 Biologia Aplicada (Degree)
Universidade do Minho, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/03/31 - Current Webinar: O caminho para a patologia digital na anatomia patológica (2023/03/31)
Seminar (Co-organisor)
 Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2008 - Current I Simpósio Técnico de Anatomia Patológica - Novos Desafios (2008/05/31)
Symposium (Co-organisor)
 Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2022/05/02 - 2022/05/04 Curso online: citometria de flux o espectral (2022/05/02)
Symposium (Member of the Organising Committee)
 Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2019/09/17 - 2019/09/19 ISCaM 2019 6th Annual meeting CANCER METABOLIC REWIRING: MAPPING THE ROAD TO CLINICAL TRANSLATION (2019/09)
Congress (Member of the Organising Committee)
2011/05/20 - 2011/05/22 XII Congresso Tecnico de Anatomia Patologica (2011/05)
Congress (Member of the Organising Committee)
 Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/01/11 Short-chain fatty acids as potential modulators of a new ruthenium-based anticancer drug in colorectal cancer therapy
(Thesis) Main arguer
 Renata Filipe Oliveira Matos (Master)
Universidade do Minho, Portugal
2023/11/23 Sequenciação de Nova Geração: Impacto de um Painel Multigénico para a Identificação de Indivíduos com Risco de Cancro da Mama e Ovário Hereditário
President of the jury
 Julieta Conceição Mendes Borges Oliveira (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023/11/20 Validação da sequenciação por NGS de um painel dirigido para o rastreio de Trombofilias
President of the jury
 Juliana Filipa Oliveira Vieira (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023/11/16 Rastreio Organizado do Cancro do Colo do Útero nos Açores – Análise do impacto das alterações implementadas
President of the jury
 Débora Carina Monteiro Ramos de Melo Maciel (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023/11/13 Comparison of Hysterectomy Dissection Protocols for Endometrial Carcinoma
President of the jury
 Gisela Arlinda Pereira Magalhães (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023/11/06 Vias moleculares comuns ligadas às doenças pulmonares intersticiais com fenótipo fibrosante progressivo: o papel da variante promotora MUC5B
President of the jury
 Melany Patrícia Furtado Gonçalves (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023/09/07 Deteção do Cancro da Próstata por Inteligência Artificial em Histopatologia: Uma Revisão Bibliográfica
President of the jury
 Bia Alexandra Gonçalves de Pinho (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023/09/04 Análise de Variantes no gene STK11 e sua influência na resposta à imunoterapia
President of the jury
 Ana Filipa Moreira Bessa (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023/09/04 Avaliação de Artefactos de Fixação do Cristinalino em Olhos Fetais
President of the jury
 Carolina Chaves Teixeira (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023/09/04 Retinopatias hereditárias e sequenciação de ORF15 do gene RPGR
President of the jury
 Petra Takács (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023/07/27 Técnicas de Dissecação Ganglionar em Amostras Cirúrgicas de Cancro Colorretal: Revisão de literatura
President of the jury
 Cátia Vinagre Alexandre (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2022/12/02 Quantificação da carga viral de HPV de alto risco e associação com o desenvolvimento de lesões cervicais
President of the jury
 Telma Sofia Mota Oliveira (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2022/11/30 Análise de gânglios sentinela em cancro da mama: o papel do ensaio OSNA na caraterização das micrometástases e macrometástases
President of the jury
 Catarina Oliveira Teixeira (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2022/03 Unravelling the role of the spinocerebellar ataxia type 3-associated protein ATXN3 in glioblastoma
(Thesis) Arguer
 Ana Margarida Machado Sousa (Master)
Universidade do Minho Escola de Medicina, Portugal
2021/11 Diagnóstico assistido por computador no cancro colorretal podemos fazê-lo?
President of the jury
 Liliana Santos (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2021/11 DGCR8 microprocessor defect and deregulation of its expression in thyroid lesions”
President of the jury
 Lia Cristiana Gomes Rodrigues (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2021/11 Doping Genético: de Atleta de Elite a Superatleta
President of the jury
 4. Ba´rbara Sofia Cunha Moreira Gomes (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2021/11 Teste pré-Natal Não Invasiso (NIPT – Non Invasive Pre-natal Test
President of the jury
 Adriana Isabel Barros Marques (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2021/08 O MCT1 como alvo terapêutico e mediado de resposta no tratamento de melanomas
(Thesis) Main arguer
 Murilo Queiroz de Almeida Bonatelli (PhD)
Hospital de Amor, Brazil
2018/10/29 Targeting cancer cell metabolism using targeted drug delivery systems
Supervisor
 Andreia Nunes (Master)
Universidade do Minho Escola de Medicina, Portugal
2018/10/16 Elucidating the impact of IL-17A/F in lung cancer
Supervisor
 Nathalia Ferreira (Master)
Universidade do Minho Escola de Medicina, Portugal
2018/01 Role of CD147 and MCT in cisplatin resistance in the setting of Urotherial Bladder Cancer
(Thesis) Arguer
 Diogo Spínola Vasconcelos (Master)
Universidade do Minho Escola de Medicina, Portugal
2018/01 Estudo dos fatores de prognóstico em doentes com o diagnóstico de carcinoma Epidermoide da Cabeça e Pescoço submetidos a quimioterapia e radioterapia adjuvantes após cirurgia.
(Thesis) Arguer
 Maria Beatriz Sousa Moreira de Castro Borges (Master)
Universidade do Minho Escola de Medicina, Portugal
2016/01 Avaliação da expressão da Anidrase Carbónica IX (CAIX) em Cancro Colorretal e respetivas metástases ganglionares através da técnica de imunohistoquímica
(Thesis) Arguer
 Ângela Maria de Azevedo Rodrigues (Master)
Universidade do Minho Escola de Medicina, Portugal
2015/12 Androgens and calcium-binding protein regucalcin in the control of prostate cells metabolism and survival: implications in carcinogenesis.
(Thesis) Arguer
 Cátia Alexandra Vicente Vaz (PhD)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2015/01 Tumor response prediction in patients with head-and-neck cancer treated with radiation therapy
(Thesis) Arguer
 Humberto José da Silva Pereira Rocha (Master)
Universidade do Minho Escola de Medicina, Portugal
2015/01 Study of Schistosoma haematobium Induced Bladder Cancer Through Urinary Proteomics
(Thesis) Arguer
 Maria Cla´udia Sousa Dias Alves da Cunha (Master)
Universidade do Minho Escola de Medicina, Portugal

Association member

Society Organization name Role
2014 - Current Portuguese Association of Cancer Research (ASPIC)
2011 - Current International Society for Cancer Metabolism (ISCaM)
2010 - Current Sociedade Portuguesa de Bioquimica
2003 - 2009 Associação Portuguesa de Técnicos de Anatomia Patológica

Committee member

Activity description
Role 		Institution / Organization
2010 - Current European Association for Cancer Research (EACR)

Conference scientific committee

Conference name Conference host
2023/05/19 - 2023/05/21 XXIII Congresso Técnico de Anatomia Patológica Associação Portuguesa de Técnicos de Anatomia Patológica

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2018 - Current Metabolism and Cancer Fundamentals of Genetics, Development and Neoplasia (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2018 - Current Tumor microenvironment: the role of macrophages Fundamentals of Genetics, Development and Neoplasia Universidade do Minho Escola de Medicina, Portugal
2017 - Current Metabolism and Cancer Fundamentals of Genetics, Development and Neoplasia (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2016 - Current Metabolism and Cancer Fundamentals of Genetics, Development and Neoplasia (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2015 - Current Metabolism and Cancer Fundamentals of Genetics, Development and Neoplasia (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2014 - Current Metabolism and Cancer Fundamentals of Genetics, Development and Neoplasia (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2013/01 - Current Immunohistochemistry of cancer tissues Fundamentals of Genetics, Development and Neoplasia (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2013 - Current Immunohistochemistry of cancer tissues (proliferation and metabolic markers Bionanotechnology for diagnosis and therapy of cancer (Mestrado) Universidade do Minho Escola de Ciências, Portugal
2023/03/01 - 2023/06/30 Anatomia Patológica I Ciências Biomédicas Laboratoriais (Licenciatura) Escola Superior Saúde IPPORTO, Portugal
2021/09 - 2022/01 Immunology Ciências Biomédicas Laboratoriais (Licenciatura) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2021/09 - 2022/01 Pathology Anatomy Técnicas Laboratoriais em Biopatologia (Mestrado integrado) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2017/09/06 - 2019/07/06 Histotecnology; Tissue samples preparation and analysis. Microscopy (Licenciatura) Instituto Politécnico de Castelo Branco, Portugal

Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal

Mentoring / Tutoring

Topic Student name
2016/09/01 - 2017/01/06 SPINT-2 expression in lung cancer Bruno Peixoto
2014/08/01 - 2015/06/01 Glycolytic metabolism and monocarboxylate transporters in pancreatic ductal adenocarcinoma Diana Moreira

Other jury / evaluation

Activity description Institution / Organization
2021 - Current Maria Dolores Mendes Borges, Internship; degree final project in Applied Biology; University of Minho, intitled O papel do recetor de lactato GPR81 em tumores sólidos” 2021 – Arguent Universidade do Minho Escola de Ciências, Portugal
2021 - Current Carla Sofia Pinto Fernandes; degree final project in Biochemistry; University of Minho, intitled: “Unravel the role of lactate receptor GPR81 in solid tumors” 2021 - Arguent Universidade do Minho Escola de Ciências, Portugal
2017/07 - Current Nuno Santos ; degree final project in Biochemistry; University of Minho, 2017 - Arguent Universidade do Minho Escola de Ciências, Portugal
2017/07 - Current Eduarda Gomes; degree final project in Biochemistry; University of Minho, 2017 - Arguent Universidade do Minho Escola de Ciências, Portugal
Distinctions

Award

2023 Best poster presentation XXIII Congresso Técnico de Anatomia Patológica
Associação Portuguesa de Técnicos de Anatomia Patológica, Portugal
2023 EACR Poster Prize III ASPIC ASEICA International Meeting
European Association For Cancer Research, United Kingdom
2020 Poster Presentation first Prize
Liga Portuguesa Contra o Cancro, Portugal
2019 Oral Presentation first Prize
2019 Best oral presentation 22nd International Symposium on Microencapsulation

Other distinction

2016 Pos-doc Fellowship: ref:SFRH/BPD/117858/2016
2013 Travel grant: SPSAS - Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment
2010 PhD Fellowship: ref.SFRH / BD / 51062 / 2010