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Nuno Empadinhas holds a degree in Biology and a PhD in Biochemistry with a specialty in Microbiology from the University of Coimbra (UC). He is Principal Investigator at CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra. Since 2024 he is the Coordinator of the PhD Programme in Experimental Biology and Biomedicine (PDBEB). His research is focused on the biology of nontuberculous mycobacteria (NTM), some being disinfectant-resistant opportunistic pathogens detected in drinking water, capable of causing severe antibiotic-resistant infections, yet overlooked by public health authorities. NE also interested in the gut microbiome in Parkinson's disease and biosynthesis of neuroactive compounds by gut microbiota. He has deciphered mechanisms of microbial adaptation to extreme environments (salterns, deserts, hyperthermal vents) revealing the biosynthetic pathways for glycosidic compatible solutes. He has elucidated steps in the biogenesis of polymethylated polysaccharides in Mycobacterium tuberculosis and NTM. In his career as a molecular microbiologist, he has identified genes and enzyme activities that founded several new families at the IUBMB database (https://www.enzyme-database.org/query.php?name=Empadinhas). He has supervised/co-supervised 11 PhD and 12 MSc students and 4 postdoctoral fellows, co-authored 78 papers (75% Q1) and 6 book chapters. In 2012, he was awarded the Japanese Mizutani Glycoscience Grant, the first time attributed in Portugal since its inception in 1993. His transdisciplinary research attracted ~2 million euros in funding from Fundação para a Ciência e a Tecnologia, Mizutani Foundation for Glycoscience, Santa Casa da Misericórdia de Lisboa, Infarmed, Cure Parkinson's UK, and was awarded the Mantero Belard Prize (2016), the Thomé Villar Award (2017), the Seed Project Award UC (2020), and the Pfizer Award of Basic Research (2023).
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Identification

Personal identification

Full name
Nuno Miguel da Silva Empadinhas

Citation names

  • Empadinhas, Nuno

Author identifiers

Ciência ID
C511-C024-BE7A
ORCID iD
0000-0001-8938-7560
Google Scholar ID
https://scholar.google.com/citations?hl=en&user=-jHQdEgAAAAJ&view_op=list_works
Researcher Id
AAC-6157-2019
Scopus Author Id
6602504934

Email addresses

  • nuno.empadinhas@uc.pt (Professional)
  • numenius@cnc.uc.pt (Professional)
  • nempadinhas@gmail.com (Personal)

Telephones

Telephone
  • (+351) 304502931 (Professional)
  • (+351) 239820190 Ext.: 140 (Professional)

Addresses

  • Centro de Neurociências e Biologia Celular (CNC), Rua Larga, Universidade de Coimbra, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Health Sciences - Infectious Diseases
Education
Degree Classification
2000 - 2004
Concluded
 Bioquímica (Doutoramento)
Major in Specialty in Microbiology
Universidade de Coimbra, Portugal
"Pathways for the synthesis of mannosylglycerate in prokaryotes. Genes, enzymes and evolutionary implications" (THESIS/DISSERTATION)
 Distinction and Honours
1997 - 1999
Concluded
 Biologia Celular (Curso de mestrado (conclusão do curso de especialização))
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 Very Good
1990 - 1996
Concluded
 Biologia (Licenciatura)
Major in Microbiologia
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"A flora bacteriana num sistema de engarrafamento de água mineral: caracterização por RAPD-PCR" (THESIS/DISSERTATION)
 Good (14/20)
Affiliation

Science

Category
Host institution 		Employer
2024 - Current Principal Investigator (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal
2019 - 2023 Principal Investigator (Research) Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal
Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal
2008 - 2018 Auxiliary Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1998 - 2004 Visiting Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2008 - 2011 Invited Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Positions / Appointments

Category
Host institution 		Employer
2024/06/01 - Current Coordinator of the Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Projects

Contract

Designation Funders
2023 - 2026 Validation of bacterial-derived anti-inflammatory mediators in gut-first PD
CP code: SC01
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Cure Parkinson's UK
Ongoing
2023 - 2025 Exploring bacterial interactions to find novel molecules to combat the antimicrobial resistance catastrophe
2022.06809.PTDC
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2025 Nontuberculous mycobacteria from drinking water: beyond the lung disease epidemic
PTDC/BIA-MIC/0122/2021
Principal investigator
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Administração Regional de Saúde do Centro IP, Portugal

Universidade do Porto Instituto de Saúde Pública, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2023 Microbiome-miRNAs axis in Parkinsons disease: involvement of mitochondrial mediated inflammatory response
EXPL/MED-NEU/1515/2021
Researcher
Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2021 - 2023 The Gut-Immune-Brain Axis in Parkinson disease
PTDC/MED-NEU/3644/2020
Co-Principal Investigator (Co-PI)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2022 Green method to prepare sterilized biopolymers based aerogel
PTDC/EQU-EPQ/32625/2017
Researcher
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/06/15 - 2021/12/31 An intriguing mycobacterial polysaccharide: recycling, replication and beyond
PTDC/BTM-TEC/29221/2017
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020 - 2021 Sustainable and dual function polymeric edible films: a probiotic and antioxidant delivery food packaging system
Prémio Projetos Semente de I&D "Era pós-COVID 19: uma sociedade mais sustentável, resiliente e justa
Researcher
Universidade de Coimbra, Portugal
 Universidade de Coimbra/Santander
Concluded
2017 - 2021 HealthyAging2020 (WP9 - Deciphering microbiome signatures in chronic diseases for early diagnosis and modulation therapies) (Institutional-HR)
CENTRO-01-0145-FEDER-000012-N2323
Researcher
Universidade de Coimbra - Centro de Neurociências e Biologia Celular, Portugal

CNC.IBILI, Portugal
European Regional Development Fund

Comissão de Coordenação e Desenvolvimento Regional do Centro
Concluded
2017 - 2020 The toxinogenic gut microbiome in sporadic Parkinson's Disease: a quest for "antiPDbiotics"
Mantero Belard Prize 2016 - MB-40-2016
Co-Principal Investigator (Co-PI)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Santa Casa da Misericórdia de Lisboa
Concluded
2018 - 2018 Prevalência de micobactérias não-tuberculosas em ambiente doméstico
Prémio Thomé Villar/Boehringer Ingelheim 2017
Co-Principal Investigator (Co-PI)
Universidade do Porto Instituto de Saúde Pública, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Sociedade Portuguesa de Pneumologia

Boehringer Ingelheim Portugal
Concluded
2016 - 2018 Microcare - Microbiome of diabetic ulcers: early diagnosis, prognosis and therapy
FIS-2015-01_DIA_20150630-144
Co-Principal Investigator (Co-PI)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

CNC.IBILI, Portugal
Infarmed - Fundo para a Investigação em Saúde
Concluded
2016 - 2016 The impairment of neuronal metabolism by gut microbiome effectors
FMUC-BST-2016-221
Researcher
Universidade de Coimbra Faculdade de Medicina, Portugal
 Faculdade de Medicina, Universidade de Coimbra & Banco Santander
Concluded
2014 - 2015 Produção e comercialização global de compostos microbianos para investigação
InovC 2014
Principal investigator
Universidade de Coimbra, Portugal
 European Regional Development Fund
Concluded
2013 - 2015 Biosynthesis of rare methylmannose polysaccharides in nontuberculous mycobacteria
PTDC/BIA-MIC/2779/2012
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2015 Ambiguity and virulence in a human pathogen
PTDC/BBB-BEP/0695/2012
Researcher
Instituto de Biologia Molecular e Celular, Portugal

Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012 - 2014 Unravelling the early steps in the biosynthesis of the mycobacterial MGLP
Grant 120123
Principal investigator
Universidade de Coimbra - Centro de Neurociências e Biologia Celular, Portugal
 Mizutani Foundation for Glycoscience
Concluded
2011 - 2014 Pathway for the synthesis of the mycobacterial MGLP. Biochemical and structural characterization of the key enzymes
PTDC/BIA-PRO/110523/2009
Principal investigator
Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2013 The enigmatic mycobacterial maltokinase
PTDC/BIA-BCM/112459/2009
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2010 Characterization and evolution of a rare glycosyltransferase from the antitumor producing bacteria of the genus Actinosynnema
Acordo Cultural 2010 Eslováquia 124626903612592
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008 - 2010 Cloning, expression and regulation of genes for the synthesis of compatible solutes in Thermus thermophilus
Acção Nº E-9/08
Researcher
Universidade de Coimbra, Portugal

Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal
Conselho de Reitores das Universidades Portuguesas, Portugal
Concluded
2005 - 2008 Compatible solutes from extremophiles: screening, biosynthesis and heterologous production
POCI/V.5/A0005/2005
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005 - 2008 Nature´s shields to environmental stress. Biosynthesis of compatible solutes in extremely radiation-resistant Rubrobacter spp.
POCI/BIA-MIC/56511/2004
Researcher
Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2004 - 2006 Hotsolutes: New applications for compatible solutes from Extremophiles
COOP-CT-2003-508644
Post-doc Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal
European Commission
Concluded
2002 - 2004 Hypersolutes: Exploiting new solutes from hyperthermophiles for the preservation of biomaterials: cell factories for production of hypersolutes
QLK3-CT-2000-00640
PhD Student Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Commission
Concluded
2001 - 2004 Towards the Utilization of Cell-Reactors for the Production of Mannosylglycerate, an Enzyme Stabilizer from Hyperthermophiles
POCTI/BIO/35715/1999
PhD Student Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1997 - 1999 Extremophiles as cell factories
BIO4960488
Master Student Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 European Commission
Concluded

Other

Designation Funders
2021 - 2025 DYNABrain - Dynamic Brain Function: Towards the Understanding and Treatment of Brain Disorders (ERA Chairs - Institutional)
H2020-WIDESPREAD-2018-2020-6, ID: 952422
WIDESPREAD-06-2020 - ERA Chairs
Other
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 European Commission
Ongoing
2021 - 2025 CIBB - Center for Innovative Biomedicine and Biotechnology - Associate Laboratory (Institutional)
LA/P/0058/2020
10.54499/LA/P/0058/2020
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020 - 2023 CIBB - Center for Innovative Biomedicine and Biotechnology (Institutional)
UIDB/04539/2020 and UIDP/04539/2020
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Candeias E, Nunes-Costa D, Pereira-Santos AR, Magalhães JD, Melo-Marques I, Guedes B, Esteves AR, Empadinhas N, Cardoso. "Neurotoxicity induced by the microbial metabolite ß-methylamino-L-alanine: pathways and mechanisms". In Natural Molecules in Neuroprotection and Neurotoxicity, edited by Marcos Oliveira, 747-778. United States: Elsevier Inc., 2024.
    Published • 10.1016/b978-0-443-23763-8.00068-3
  2. Nuno Empadinhas. "Cerveja de precisão e saúde: do intestino ao cérebro". In A Cerveja - Património de Coimbra e do Mundo, edited by coord. Carla Barbosa & Pedro Baptista; Almedina & Praxis. Coimbra, Portugal: Almedina, 2023.
    Published
  3. Nuno Empadinhas, Susana Alarico, Ana Maranha, Daniela Nunes-Costa, Inês Roxo. "Micobactérias da água: uma ameaça silenciosa". In A Saúde no Saber - Um Projeto de Promoção da Literacia em Saúde, edited by Maria João Padez de Castro. Coimbra, Portugal: Imprensa da Universidade de Coimbra, 2023.
    Published
  4. Costa J, Empadinhas N, Alarico S, Nobre A, Albuquerque L, da Costa MS. "The biosynthesis of trehalose and sugar-glycerate compatible solutes in organisms that live in hot and saline environments". In Marine Enzymes for Biocatalysis, 465-502. Elsevier, 2013.
    Published • 10.1533/9781908818355.3.465
  5. da Costa MS, Empadinhas N. "Biosynthesis of the Compatible Solute Mannosylglycerate from Hyperthermophiles to Mesophiles". In Adaptation to Life at High Salt Concentrations in Archaea, Bacteria, and Eukarya, 311-325. Springer Netherlands, 2005.
    Published • 10.1007/1-4020-3633-7_21
  6. Empadinhas N, Silva Z, da Costa MS. "Os solutos compatíveis como estratégia de sobrevivência a agressão osmótica". In Biotecnologia - Fundamentos e Aplicações (ISBN: 978-972-757-197-0), edited by Nelson Lima, Manuel Mota, 51-67. Portugal: Lidel, 2003.
    Published
Journal article
  1. Munoz-Pinto MFª, Candeias Eª, Melo-Marques Iª, Esteves AR, Maranha A, Magalhães JD, Carneiro DR, Sant'Anna M; Pereira-Santos AR, Abreu AE, Nunes-Costa D, Alarico S, Tiago I, Morgadinho A, Lemos J, Figueiredo PN, Januário C; Empadinhas N, Cardoso SM. "Gut-first Parkinson's disease is encoded by gut dysbiome". Molecular Neurodegeneration 19 (2024): https://doi.org/10.1186/s13024-024-00766-0.
    Published • https://doi.org/10.1186/s13024-024-00766-0
  2. Bento C, Lopes D, Villarreal C, Empadinhas N, Alarico S, de Sousa HC, Braga MEM. "Integrated processes (HPSE+scCO2) to prepare sterilized alginate-gelatine-based aerogel". International Journal of Pharmaceutics 662 (2024): 124546. http://dx.doi.org/10.1016/j.ijpharm.2024.124546.
    Published • 10.1016/j.ijpharm.2024.124546
  3. Melo-Marques I, Cardoso SM, Empadinhas N. "Bacterial extracellular vesicles at the interface of gut microbiota and immunity". Gut Microbes 16 1 (2024): http://dx.doi.org/10.1080/19490976.2024.2396494.
    Published • 10.1080/19490976.2024.2396494
  4. Antoniuk O, Maranha A, Salvador J, Empadinhas N, Moreira V. "Bi- and tricyclic diterpenoids: landmarks from a decade (2013–2023) in search of leads against infectious diseases". Natural Product Reports (2024): http://dx.doi.org/10.1039/d4np00021h.
    Published • 10.1039/d4np00021h
  5. Maranha A, Alarico S, Nunes-Costa D, Melo-Marques I, Roxo I, Castanheira P, Caramelo O, Empadinhas N. "Drinking water microbiota, entero-mammary pathways, and breast cancer: Focus on nontuberculous mycobacteria". Microorganisms 12 7 (2024): 1425. http://dx.doi.org/10.3390/microorganisms12071425.
    Open access • Published • 10.3390/microorganisms12071425
  6. Candeias E, Pereira-Santos AR, Empadinhas N, Cardoso SM, Esteves AR. "The Gut-Brain Axis in Alzheimer’s and Parkinson’s Diseases: The Catalytic Role of Mitochondria". Journal of Alzheimer's Disease (2024): 1-17. http://dx.doi.org/10.3233/jad-240524.
    Published • 10.3233/jad-240524
  7. Pereira-Santos AR, Candeias E, Magalhães JD, Empadinhas N, Esteves AR, Cardoso SM. "Neuronal control of microglia through the mitochondria". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2024): 167167. http://dx.doi.org/10.1016/j.bbadis.2024.167167.
    Published • 10.1016/j.bbadis.2024.167167
  8. Magalhães JD, Candeias E, Melo-Marques I, Abreu AE, Pereira-Santos AR, Esteves AR, Cardoso SM, Empadinhas N. "Nocardia cyriacigeorgica elicits gut disturbances in a leaky gut model of colitis, but not the harmful cascade leading to gut-first Parkinson’s Disease". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25063423.
    Published
  9. Sacoor C, Marugg JD, Lima NR, Empadinhas N, Montezinho L. "Gut-brain-axis impact on canine anxiety disorders: new challenges for behavioral veterinary medicine". Veterinary Medicine International 2024 2856759 (2024): https://doi.org/10.1155/2024/2856759.
    Published
  10. Bento CSA, Carrelo H, Alarico S, Empadinhas N, de Sousa HC, Cidade MT, Braga MEM. "Effect of ScCO2 on the decontamination of PECs-based cryogels: a comparison with H2O steam and H2O2 nebulization methods". International Journal of Pharmaceutics (2023): 123451. http://dx.doi.org/10.1016/j.ijpharm.2023.123451.
    Published • 10.1016/j.ijpharm.2023.123451
  11. Coimbra P, Alarico S, Empadinhas N, Braga MEM, Gaspar MC. "Sustainable starch-based edible films with agrifood residues as potential carriers for the probiotic Lactobacillus rhamnosus". Innovative Food Science & Emerging Technologies 88 (2023): 103452. http://dx.doi.org/10.1016/j.ifset.2023.103452.
    Published • 10.1016/j.ifset.2023.103452
  12. Magalhães JD, Candeias E, Melo-Marques I, Silva DF, Esteves AR, Empadinhas N, Cardoso SM. "Intestinal infection triggers mitochondria-mediated a-synuclein pathology: relevance to Parkinsons disease". Cellular and Molecular Life Sciences 80 6 (2023): http://dx.doi.org/10.1007/s00018-023-04819-3.
    Published • 10.1007/s00018-023-04819-3
  13. Magalhães JD, Esteves AR, Candeias E, Silva DF, Empadinhas N, Cardoso SM. "The role of bacteria-mitochondria communication in the activation of neuronal innate immunity: Implications to Parkinson's Disease". International Journal of Molecular Sciences 24 5 (2023): 4339. http://dx.doi.org/10.3390/ijms24054339.
    Published • 10.3390/ijms24054339
  14. Maranha A, Costa M, Ripoll-Rozada J, Manso JA, Miranda V, Mendes V, Manadas B, Macedo-Ribeiro S, Ventura MR; Pereira PJB, Empadinhas N. "Self-recycling and partially conservative replication of mycobacterial methylmannose polysaccharides". Communications Biology 6 1 (2023): 108. https://doi.org/10.1038/s42003-023-04448-3.
    Published • 10.1038/s42003-023-04448-3
  15. Esteves AR, Muñoz-Pinto MF, Nunes-Costa D, Candeias E, Silva DF, Magalhães JD, Pereira-Santos AR, Ferreira IL; Alarico S, Tiago I, Empadinhas N, Cardoso SM. "Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria". Gut 72 1 (2023): 73-89. http://dx.doi.org/10.1136/gutjnl-2021-326023.
    Published • 10.1136/gutjnl-2021-326023
  16. Costa HN, Esteves AR, Empadinhas N, Cardoso SM. "Parkinson's Disease: A Multisystem Disorder". Neuroscience Bulletin 39 1 (2023): 113-124. http://dx.doi.org/10.1007/s12264-022-00934-6.
    Published • 10.1007/s12264-022-00934-6
  17. Silva DF, Empadinhas N, Cardoso SM, Esteves AR. "Neurodegenerative Microbially-Shaped Diseases: Oxidative Stress Meets Neuroinflammation". Antioxidants 11 11 (2022): 2141. http://dx.doi.org/10.3390/antiox11112141.
    Published • 10.3390/antiox11112141
  18. Bento C, Alarico S, Empadinhas N, Sousa HC, Braga MEM. "Sequential scCO2 drying and sterilisation of alginate-gelatine aerogels for biomedical applications". The Journal of Supercritical Fluids 184 (2022): 105570. http://dx.doi.org/10.1016/j.supflu.2022.105570.
    Published • 10.1016/j.supflu.2022.105570
  19. Gonçalves S, Nunes-Costa D, Cardoso SM, Empadinhas N, Marugg JD. "Enzyme promiscuity in serotonin biosynthesis, from bacteria to plants and humans". Frontiers in Microbiology 13 (2022): http://dx.doi.org/10.3389/fmicb.2022.873555.
    Published • 10.3389/fmicb.2022.873555
  20. Muñoz-Pinto MF, Empadinhas N, Cardoso SM. "The neuromicrobiology of Parkinson's disease: A unifying theory". Ageing Research Reviews 70 (2021): 101396. http://dx.doi.org/10.1016/j.arr.2021.101396.
    Published • 10.1016/j.arr.2021.101396
  21. Gonçalves AM, Pereira-Santos AR, Esteves AR, Cardoso SM, Empadinhas N. "The Mitochondrial Ribosome: A World of Opportunities for Mitochondrial Dysfunction Toward Parkinson's Disease". Antioxidants & Redox Signaling 34 8 (2021): 694-711. https://www.liebertpub.com/doi/10.1089/ars.2019.7997.
    Published • 10.1089/ars.2019.7997
  22. Mouritzen MV, Petkovic M, Qvist K, Poulsen SS, Alarico S, Leal EC, Dalgaard LT, Empadinhas N, Carvalho E, Jenssen H. "Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota". Molecular Therapy - Methods & Clinical Development 20 (2021): 726-739. https://doi.org/10.1016/j.omtm.2021.02.008.
    Published • 10.1016/j.omtm.2021.02.008
  23. Silva DF, Candeias E, Esteves AR, Magalhães JD, Ferreira IL, Nunes-Costa D, Rego AC, Empadinhas N, Cardoso SM. "Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation and Alzheimer's disease features in cortical neurons". Journal of Neuroinflammation 17 332 (2020): http://dx.doi.org/10.1186/s12974-020-02004-y.
    Published • 10.1186/s12974-020-02004-y
  24. Oriá RB, Empadinhas N, Malva JO. "Editorial: Interplay Between Nutrition, the Intestinal Microbiota and the Immune System". Frontiers in Immunology 11 (2020): http://dx.doi.org/10.3389/fimmu.2020.01758.
    Published • 10.3389/fimmu.2020.01758
  25. Alarico S, Nunes-Costa D, Silva A, Costa M, Macedo-Ribeiro S, Empadinhas N. "A genuine mycobacterial thermophile: Mycobacterium hassiacum growth, survival and GpgS stability at near-pasteurization temperatures". Microbiology 166 5 (2020): 474-483. http://dx.doi.org/10.1099/mic.0.000898.
    Published • 10.1099/mic.0.000898
  26. Silva MB, Lepzienj R, Ols S, Dahlbergh B, Grunewaldh J, Lore K, Smed-Sörensen A, Correia-Neves M, Empadinhas N; Färnert A, Källenius G, Sundling C. "Stabilization of blood for long-term storage can affect antibody-based recognition of cell surface markers". Journal of Immunological Methods 481 (2020): 112792. http://dx.doi.org/10.1016/j.jim.2020.112792.
    Published • 10.1016/j.jim.2020.112792
  27. Nunes-Costa D, Magalhães JD, G-Fernandes M, Cardoso SM, Empadinhas N. "Microbial BMAA and the Pathway for Parkinson's Disease Neurodegeneration". Frontiers in Aging Neuroscience 12 (2020): https://doi.org/10.3389/fnagi.2020.00026.
    Published • 10.3389/fnagi.2020.00026
  28. Cereija TB, Alarico S, Lourenço EC, Manso JA, Ventura MR, Empadinhas N, Macedo-Ribeiro S, Pereira PJB. "The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation". IUCrJ 6 4 (2019): 572-585. https://doi.org/10.1107/S2052252519005372.
    Published • 10.1107/S2052252519005372
  29. Tiago I, Alarico S, Maranha A, Coelho C, Pereira SG, Empadinhas N. "High-Quality Draft Genome Sequences of Rare Nontuberculous Mycobacteria Isolated from Surfaces of a Hospital". Microbiology Resource Announcements 8 21 (2019): https://doi.org/10.1128/MRA.00496-19.
    Published • 10.1128/MRA.00496-19
  30. Manso JA, Nunes-Costa D, Macedo-Ribeiro S, Empadinhas N, Pereira PJB. "Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity". mBio (2019): https://doi.org/10.1128/mBio.00239-19.
    Published • 10.1128/mBio.00239-19
  31. Pereira SG, Alarico S, Tiago I, Reis D, Nunes-Costa D, Cardoso O, Maranha A, Empadinhas N. "Studies of antimicrobial resistance in rare mycobacteria from a nosocomial environment". BMC Microbiology 19 1 (2019): http://dx.doi.org/10.1186/s12866-019-1428-4.
    Published • 10.1186/s12866-019-1428-4
  32. Ripoll-Rozada J, Costa M, Manso JA, Maranha A, Miranda V, Sequeira A, Ventura MR, Macedo-Ribeiro S,; Pereira PJB; Empadinhas N. "Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides". Proceedings of the National Academy of Sciences (2019): 201813450-201813450. https://www.pnas.org/content/116/3/835.long.
    Published • 10.1073/pnas.1813450116
  33. Cardoso SM, Empadinhas N. "The Microbiome-Mitochondria Dance in Prodromal Parkinson's Disease". Frontiers in Physiology 9 (2018): https://www.frontiersin.org/articles/10.3389/fphys.2018.00471/full.
    Published • 10.3389/fphys.2018.00471
  34. Cereija TB, Alarico S, Empadinhas N, Pereira PJB. "Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase". Acta Crystallographica Section F Structural Biology Communications 73 9 (2017): 536-540. https://doi.org/10.1107%2Fs2053230x17012419.
    Published • 10.1107/S2053230X17012419
  35. Pereira SG, Moura J, Carvalho E, Empadinhas N. "Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies". Frontiers in Microbiology 8 (2017): https://doi.org/10.3389%2Ffmicb.2017.01791.
    Published • 10.3389/fmicb.2017.01791
  36. Farias PG, Gama FJ, Reis D, Alarico S, Empadinhas N, Martins JC, Almeida AF, Morais PV. "Hospital microbial surface colonization revealed during monitoring of Klebsiella spp., Pseudomonas aeruginosa, and non-tuberculous mycobacteria". Antonie van Leeuwenhoek 110 7 (2017): 863-876. http://dx.doi.org/10.1007/s10482-017-0857-z.
    Published • 10.1007/s10482-017-0857-z
  37. Nunes-Costa D, Maranha A, Costa M, Alarico S, Empadinhas N. "Glucosylglycerate metabolism, bioversatility and mycobacterial survival". Glycobiology 27 (2016): 213-227. http://dx.doi.org/10.1093/glycob/cww132.
    Published • 10.1093/glycob/cww132
  38. Nunes-Costa D, Alarico S, Dalcolmo MP, Correia-Neves M, Empadinhas N. "The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil". Tuberculosis 96 (2016): 107-119. http://dx.doi.org/10.1016/j.tube.2015.09.006.
    Published • 10.1016/j.tube.2015.09.006
  39. Mendes V, Blaszczyk M, Maranha A, Empadinhas N, Blundell TL. "Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep17144.
    Published • 10.1038/srep17144
  40. Maranha A, Moynihan PJ, Miranda V, Lourenço EC, Nunes-Costa D, Fraga JS, Pereira PJB, Macedo-Ribeiro S, Ventura MR; Clarke AJ, Empadinhas N. "Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep13610.
    Published • 10.1038/srep13610
  41. Fraga JS, Maranha A, Mendes V, Pereira PJB, Empadinhas N*, Macedo-Ribeiro S*. "Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway". Scientific Reports 5 (2015): https://doi.org/10.1038/srep08026.
    Published • 10.1038/srep08026
  42. Alarico S, Costa M, Sousa MS, Maranha A, Lourenço EC, Faria TQ, Ventura MR, Empadinhas N. "Mycobacterium hassiacum recovers from nitrogen starvation with up-regulation of a novel glucosylglycerate hydrolase and depletion of the accumulated glucosylglycerate". Scientific Reports 4 1 (2014): http://dx.doi.org/10.1038/srep06766.
    Published • 10.1038/srep06766
  43. Bento CF, Empadinhas N, Mendes N. "Autophagy in the fight against tuberculosis". DNA and Cell Biology 34 4 (2014): 228-242. https://doi.org/10.1089/dna.2014.2745.
    Published • 10.1089/dna.2014.2745
  44. Nobre A, Alarico S, Maranha A, Mendes V, Empadinhas N. "The molecular biology of mycobacterial trehalose in the quest for advanced tuberculosis therapies". Microbiology (United Kingdom) 160 PART 8 (2014): 1547-1570. https://doi.org/10.1099/mic.0.075895-0.
    Published • 10.1099/mic.0.075895-0
  45. Alarico S, Empadinhas N, da Costa MS. "A new bacterial hydrolase specific for the compatible solutes alpha-D-mannopyranosyl-(1,2)-D-glycerate and alpha-D-glucopyranosyl-(1,2)-D-glycerate". Enzyme and Microbial Technology 52 2 (2013): 77-83. http://dx.doi.org/10.1016/j.enzmictec.2012.10.008.
    Published • 10.1016/j.enzmictec.2012.10.008
  46. Nobre A, Empadinhas N, Nobre MF, Lourenço EC, Maycock C, Ventura MR, Mingote A, da Costa MS. "The plant Selaginella moellendorffii possesses enzymes for synthesis and hydrolysis of the compatible solutes mannosylglycerate and glucosylglycerate". Planta 237 3 (2013): 891-901. https://doi.org/10.1007/s00425-012-1808-6.
    Published • 10.1007/s00425-012-1808-6
  47. Tiago I, Maranha A, Mendes V, Alarico S, Moynihan PJ, Clarke AJ, Macedo-Ribeiro S, Pereira PJB, Empadinhas N. "Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of heat-stable mycobacterial proteins". Journal of Bacteriology 194 24 (2012): 7010-7011. DOI: https://doi.org/10.1128/JB.01880-12.
    Published • 10.1128/JB.01880-12
  48. Mendes V, Maranha A, Alarico S, Empadinhas N. "Biosynthesis of mycobacterial methylglucose lipopolysaccharides". Natural Product Reports 29 8 (2012): 834-844. https://doi.org/10.1039/C2NP20014G.
    Published • 10.1039/c2np20014g
  49. Mendes V, Maranha A, Alarico S, da Costa MS, Empadinhas N. "Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis". Scientific Reports 1 1 (2011): http://dx.doi.org/10.1038/srep00177.
    Published • 10.1038/srep00177
  50. Empadinhas N, Pereira PJB, Albuquerque L, Costa J, Sá-Moura B, Marques AT, Macedo-Ribeiro S, da Costa MS. "Functional and structural characterization of a novel mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus reveals its dual substrate specificity". Molecular Microbiology 79 1 (2011): 76-93. https://doi.org/10.1111/j.1365-2958.2010.07432.x.
    Published • 10.1111/j.1365-2958.2010.07432.x
  51. Empadinhas N, da Costa MS. "Diversity, biological roles and biosynthetic pathways for sugar-glycerate containing compatible solutes in bacteria and archaea". Environmental Microbiology 13 8 (2011): 2056-2077. https://doi.org/10.1111/j.1462-2920.2010.02390.x.
    Published • 10.1111/j.1462-2920.2010.02390.x
  52. Fernandes C, Mendes V, Costa J, Empadinhas N, Jorge C, Lamosa P, Santos H, da Costa MS. "Two alternative pathways for the synthesis of the rare compatible solute mannosylglucosylglycerate in Petrotoga mobilis". Journal of Bacteriology 192 6 (2010): 1624-1633. https://doi.org/10.1128/JB.01424-09.
    Published • 10.1128/JB.01424-09
  53. Mendes V, Maranha A, Lamosa P, da Costa MS, Empadinhas N. "Biochemical characterization of the maltokinase from Mycobacterium bovis BCG". BMC Biochemistry (2010): https://doi.org/10.1186/1471-2091-11-21.
    Published • 10.1186/1471-2091-11-21
  54. Nobre A, Alarico S, Fernandes C, Empadinhas N, da Costa MS. "A Unique Combination of Genetic Systems for the Synthesis of Trehalose in Rubrobacter xylanophilus: Properties of a Rare Actinobacterial TreT". Journal of Bacteriology 190 24 (2008): 7939-7946. http://dx.doi.org/10.1128/jb.01055-08.
    Published • 10.1128/jb.01055-08
  55. Empadinhas N, Albuquerque L, Mendes V, Macedo-Ribeiro S, da Costa MS. "Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase". FEMS Microbiology Letters 280 2 (2008): 195-202. https://doi.org/10.1111/j.1574-6968.2007.01064.x.
    Published • 10.1111/j.1574-6968.2007.01064.x
  56. Sá-Moura B, Albuquerque L, Empadinhas N, da Costa MS, Pereira PJB, Macedo-Ribeiro S. "Crystallization and preliminary crystallographic analysis of mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 64 8 (2008): 760-763. https://doi.org/10.1107/S1744309108021490.
    Published • 10.1107/S1744309108021490
  57. Empadinhas N, da Costa MS. "To be or not to be a compatible solute: Bioversatility of mannosylglycerate and glucosylglycerate". Systematic and Applied Microbiology 31 3 (2008): 159-168. https://doi.org/10.1016/j.syapm.2008.05.002.
    Published • 10.1016/j.syapm.2008.05.002
  58. Empadinhas N, da Costa MS. "Osmoadaptation mechanisms in prokaryotes: Distribution of compatible solutes". International Microbiology 11 3 (2008): 151-161. https://europepmc.org/article/med/18843593.
    Published • 10.2436/20.1501.01.55
  59. Pereira PJB, Empadinhas N, Albuquerque L, Sá-Moura B, da Costa MS, Macedo-Ribeiro S. "Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: Structure of a key enzyme in methylglucose lipopolysaccharide biosynthesis". PLoS ONE 3 11 (2008): https://doi.org/10.1371/journal.pone.0003748.
    Published • 10.1371/journal.pone.0003748
  60. Alarico S, da Costa MS, Empadinhas N. "Molecular and physiological role of the trehalose-hydrolyzing a-glucosidase from Thermus thermophilus HB27". Journal of Bacteriology 190 7 (2008): 2298-2305. http://www.scopus.com/inward/record.url?eid=2-s2.0-41549086172&partnerID=MN8TOARS.
    Published • 10.1128/JB.01794-07
  61. Fernandes C, Empadinhas N, da Costa MS. "Single-step pathway for synthesis of glucosylglycerate in Persephonella marina". Journal of Bacteriology 189 11 (2007): 4014-4019. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249786874&partnerID=MN8TOARS.
    Published • 10.1128/JB.00075-07
  62. Empadinhas N, Mendes V, Simões C, Santos MS, Mingote A, Lamosa P, Santos H, da Costa MS. "Organic solutes in Rubrobacter xylanophilus: The first example of di-myo-inositol-phosphate in a thermophile". Extremophiles 11 5 (2007): 667-673. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548303944&partnerID=MN8TOARS.
    Published • 10.1007/s00792-007-0084-z
  63. Alarico S, Empadinhas N, Mingote A, Simões C, Santos MS, da Costa MS. "Mannosylglycerate is essential for osmotic adjustment in Thermus thermophilus strains HB27 and RQ-1". Extremophiles 11 6 (2007): 833-840. http://www.scopus.com/inward/record.url?eid=2-s2.0-35748948644&partnerID=MN8TOARS.
    Published • 10.1007/s00792-007-0106-x
  64. Costa J, Empadinhas N, da Costa MS. "Glucosylglycerate biosynthesis in the deepest lineage of the Bacteria: Characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina". Journal of Bacteriology 189 5 (2007): 1648-1654. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947366922&partnerID=MN8TOARS.
    Published • 10.1128/JB.00841-06
  65. Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura MR, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H. "Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol: Inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles". Journal of Bacteriology 189 15 (2007): 5405-5412. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547629796&partnerID=MN8TOARS.
    Published • 10.1128/JB.00465-07
  66. Empadinhas N, da Costa MS. "Diversity and biosynthesis of compatible solutes in hyper/thermophiles". International Microbiology 9 3 (2006): 199-206. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750584278&partnerID=MN8TOARS.
    Published
  67. Costa J, Empadinhas N, Gonçalves L, Lamosa P, Santos H, da Costa MS. "Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii". Journal of Bacteriology 188 3 (2006): 1022-1030. http://www.scopus.com/inward/record.url?eid=2-s2.0-31344453995&partnerID=MN8TOARS.
    Published • 10.1128/JB.188.3.1022-1030.2006
  68. Pires AL, Albuquerque L, Tiago I, Nobre MF, Empadinhas N, Veríssimo A, da Costa MS. "Meiothermus timidus sp. nov., a new slightly thermophilic yellow-pigmented species". FEMS Microbiology Letters 245 1 (2005): 39-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-15744405109&partnerID=MN8TOARS.
    Published • 10.1016/j.femsle.2005.02.011
  69. Alarico S, Empadinhas N, Simões C, Silva Z, Henne A, Mingote A, Santos H, da Costa MS. "Distribution of genes for synthesis of trehalose and mannosylglycerate in Thermus spp. and direct correlation of these genes with halotolerance". Applied and Environmental Microbiology 71 5 (2005): 2460-2466. http://www.scopus.com/inward/record.url?eid=2-s2.0-18444382346&partnerID=MN8TOARS.
    Published • 10.1128/AEM.71.5.2460-2466.2005
  70. Borges N, Marugg JD, Empadinhas N, da Costa MS, Santos H. "Specialized Roles of the Two Pathways for the Synthesis of Mannosylglycerate in Osmoadaptation and Thermoadaptation of Rhodothermus marinus". Journal of Biological Chemistry 279 11 (2004): 9892-9898. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642279326&partnerID=MN8TOARS.
    Published • 10.1074/jbc.M312186200
  71. Empadinhas N, Albuquerque L, Costa J, Zinder SH, Santos MAS, Santos H, da Costa MS. "A gene from the mesophilic bacterium Dehalococcoides ethenogenes encodes a novel mannosylglycerate synthase". Journal of Bacteriology 186 13 (2004): 4075-4084. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042523198&partnerID=MN8TOARS.
    Published • 10.1128/JB.186.13.4075-4084.2004
  72. Empadinhas N, Albuquerque L, Henne A, Santos H, da Costa MS. "The Bacterium Thermus thermophilus , Like Hyperthermophilic Archaea, Uses a Two-Step Pathway for the Synthesis of Mannosylglycerate". Applied and Environmental Microbiology 69 6 (2003): 3272-3279. http://dx.doi.org/10.1128/aem.69.6.3272-3279.2003.
    Published • 10.1128/aem.69.6.3272-3279.2003
  73. Santos P, Pinhal I, Rainey FA, Empadinhas N, Costa J, Fields B, Benson R, Veríssimo A, da Costa MS. "Gamma-Proteobacteria Aquicella lusitana gen. nov., sp. nov., and Aquicella siphonis sp. nov. Infect Protozoa and Require Activated Charcoal for Growth in Laboratory Media". Applied and Environmental Microbiology 69 11 (2003): 6533-6540. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242573382&partnerID=MN8TOARS.
    Published • 10.1128/AEM.69.11.6533-6540.2003
  74. Alarico S, Rainey FA, Empadinhas N, Schumann P, Nobre MF, da Costa MS. "Rubritepida flocculans gen. nov., sp. nov., a New Slightly Thermophilic Member of the a-1 Subclass of the Proteobacteria". Systematic and Applied Microbiology 25 2 (2002): 198-206. http://dx.doi.org/10.1078/0723-2020-00116.
    Published • 10.1078/0723-2020-00116
  75. Albuquerque L, Santos J, Travassos P, Nobre MF, Rainey FA, Wait R, Empadinhas N, Silva MT, da Costa MS. "Albidovulum inexpectatum gen. nov., sp. nov., a nonphotosynthetic and slightly thermophilic bacterium from a marine hot spring that is very closely related to members of the photosynthetic genus Rhodovulum". Applied and Environmental Microbiology 68 9 (2002): 4266-4273. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036729238&partnerID=MN8TOARS.
    Published • 10.1128/AEM.68.9.4266-4273.2002
  76. Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS. "Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii: Biochemical and genetic characterization of key enzymes". Journal of Biological Chemistry 276 47 (2001): 43580-43588. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035941355&partnerID=MN8TOARS.
    Published • 10.1074/jbc.M108054200
  77. Martins LO, Empadinhas N, Marugg JD, Miguel C, Ferreira C, da Costa MS, Santos H. "Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase". Journal of Biological Chemistry 274 50 (1999): 35407-35414. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033544948&partnerID=MN8TOARS.
    Published • 10.1074/jbc.274.50.35407
Magazine article
  1. Sandra M. Cardoso, Nuno Empadinhas. "O papel do eixo microbioma-intestino-cérebro em doenças neurodegenerativas", Cidade Solidária, 2017
  2. Nuno Empadinhas. "Fundação Mizutani, no Japão, apoia investigação inovadora realizada em Portugal", Sociedade Portuguesa de Microbiologia, 2012, https://spmicrobiologia.wordpress.com/2012/08/01/fundacao-mizutani-no-japao-apoia-investigacao-inovadora-realizada-em-portugal/.
Newspaper article
  1. Nuno Empadinhas. "Microbiologia: uma teoria de tudo para a Vida na Terra", Diário de Notícias, 2024, https://www.dn.pt/5794656047/nuno-empadinhas-podemos-entrar-numa-era-pos-antibiotico-em-que-deixaremos-de-poder-contar-com-estes/.
  2. Nuno Empadinhas, Susana Alarico, Ana Maranha, Daniela Nunes-Costa, Inês Roxo. "Micobactérias da água: uma ameaça silenciosa", Público, 2021, https://www.publico.pt/2021/10/20/ciencia/noticia/micobacterias-agua-ameaca-silenciosa-1981724.
  3. Nuno Empadinhas. "A Resistência a Antibióticos num Planeta de Micróbios e o Alerta da OMS", Diário de Coimbra, 2014
Thesis / Dissertation
  1. Empadinhas, Nuno. "Pathways for the synthesis of mannosylglycerate in prokaryotes: genes, enzymes and evolutionary implications". PhD, Universidade de Coimbra, 2005. https://estudogeral.sib.uc.pt/handle/10316/1996.
  2. Empadinhas, Nuno. "A flora bacteriana num sistema de engarrafamento de água mineral: caracterização por RAPD-PCR". Degree, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 1996.

Artistic / Performance

Visual artwork
  1. Voyages in Tuberculosis (2019) André Caetano (Art); Nuno Empadinhas & João Ramalho-Santos (Text);. João Ramalho-Santos & Sara Amaral (Coordination); with contributions from Ana Maranha, Ana Teresa Viegas, Daniela Costa, Inês Roxo, João Cardoso, Mafalda Costa, Mariana Silva and Susana Alarico (https://www.publico.pt/2019/03/24/ciencia/noticia/boicote-parede-derrubar-tuberculose-1866484).
  2. Brain Voyages (2017) In: "Público" 24/03/2017. André Caetano (Art); João Ramalho-Santos & Sara Amaral (Coordination & te. Ana Cristina Rego, Ana Luísa Carvalho, Ana Rita Álvaro, Carla Lopes, Carlos Duarte, Cláudia Cavadas, Cláudia Pereira, João Peça, Luana Naia, Luís Pereira Almeida, Nuno Empadinhas, Paula Moreira, Paulo Pinheiro, Ramiro Almeida, Ricardo Rodrigues, Sandra Morais Cardoso, Sandra Mota. (https://www.publico.pt/2017/03/24/ciencia/fotogaleria/viagens-no-cerebro-em-bd-371640).
  3. Diabetic Journeys (2017) In: "Público" 24/03/2017. André Caetano (Art); João Ramalho-Santos & Sara Amaral (Coordination. Alexandrina Mendes, Ana Duarte, Ana R Álvaro, Ana T Viegas, Cláudia Cavadas, Cristina Carvalho, Ermelindo Leal, Eugénia Carvalho, João Alves, John Jones, Ludgero Tavares, Mireia Alemany, Nuno Empadinhas, Paula Moreira, Paulo Oliveira, Pedro Gomes, Renata Tavares, Sandra Amaral, Sara Silva, Sónia Correia, Susana Cardoso (https://www.publico.pt/2017/11/14/ciencia/fotogaleria/viagens-na-diabetes-em).

Intellectual property

Patent
  1. da Costa MS, Empadinhas N. 2009. "Massive production of mycobacterial glucosyl-3-phosphoglycerate synthase and the use of this enzyme as a target for antimycobacterial substances. WO2009028973.".
  2. da Costa MS, Empadinhas N, Albuquerque L, Santos H. 2005. "Identification of a bifunctional gene for mannosylglycerate synthesis and development of a high-scale-production heterologous system based on Sacharomyces cerevisiae. EP1526180A1.".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/05/22 Da biosfera ao microbioma intestinal: alimentação, imunidade e declínio da saúde global Ciclo Sistema Imunitário e o Microbiota
CECAV - AL4AnimalS - Universidade de Trás-os-Montes e Alto Douro (Portugal)
2024/03/27 A microbiologia da doença de Parkinson: os guardiões da via intestino-cérebro Ciclo "Microbioma Humano”
Academia das Ciências de Lisboa (Portugal)
2024/03/06 Aprender com as guerras entre micróbios: dos antibióticos à doença de Parkinson Semana da Biotecnologia - Núcleo de Biotecnologia
Politécnico de Leiria - Escola Superior de Turismo e Tecnologia do Mar (Portugal)
2024/02/23 Microbioma e cancro Pós-Graduação em Bioquímica e Hematologia
Escola Superior de Tecnologia da Saúde de Coimbra (Coimbra, Portugal)
2024/01/16 Self-recycling and replication of mycobacterial methylmannose polysaccharides for adaptation to cold (Speaker: Ana Maranha) 7th Iberian Carbohydrate Meeting
(Sitges-Barcelona, Spain)
2023/05/25 Evidence of host-microbiome interactions triggering 'Gut-first' Parkinson's Disease (Speaker: Sandra Cardoso) 1st FEBS Redox Medicine Workshop: from cellular signaling to systems physiology and therapeutic targets
FEBS Advanced Course (Luso, Portugal)
2023/01/17 Methylglucose vs methylmannose polysaccharides: biosynthesis, distribution and proposed roles in adaptation of mycobacteria to heat or cold 14th International Meeting of the Portuguese Carbohydrate Group (GLUPOR 14)
NOVA School of Science and Technology, NOVA University of Lisbon, Caparica, Portugal (Caparica, Portugal)
2023/01/04 What do mycobacteria and cyanobacteria have in common when it comes to public health? DCV Talks
Life Sciences Department, UC (Coimbra, Portugal)
2022/07/14 The role of the gut microbiome in neurodegenerative diseases Portugal & Brasil Joint Meeting @CNC
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2022/06/13 Mycobacterial biogenesis of polymethylated polysaccharides FASEB - The Microbial Glycobiology Conference
FASEB Science Research Conference (SRC) (Lisboa, Portugal)
2022/05/11 Microbiome weapons and shields in metabolic, neurodegenerative and infectious diseases Programa de Doutoramento em Ciências Farmacêuticas
Faculdade de Farmácia da Universidade de Coimbra (Portugal)
2022/04/07 The gut microbiome in PD: active player or bystander? Metabolic and Inflammatory Drivers in Age-Related Neurodegenerative Diseases
PDBEB Advanced Course (Coimbra, Portugal)
2022/03/27 Microbiology of Parkinson's Disease XIII Symposium on Bioengineering "Turning Science into Miracles"
Faculdade de Engenharia da Universidade do Porto + ICBAS (Porto, Portugal)
2022/03/26 Ecologia e Epidemiologia das Micobactérias Não Tuberculosas XXIX Congresso de Pneumologia do Norte
Serviços de Pneumologia do Centro Hospitalar Universitário de São João e do Centro Hospitalar de Vila Nova de Gaia/Espinho (Centro de Congressos Sheraton Porto, Portugal)
2021/11/16 Novos caminhos de investigação em Tuberculose, na língua que nos une (Speaker: Inês Roxo) A Bienal STEM+L 2021 - Aprendizagem da Ciência, Tecnologias, Engenharia e Matemática, na Língua que nos une
OSUWELA | UNESCO | UPM (Maputo, Mozambique)
2021/07/14 Antimicrobial resistance in rare mycobacteria isolated from a tertiary hospital environment (Speaker: Ana Maranha) 4th International Caparica Congress In Antibiotic Resistance
NOVA University of Lisbon (Caparica, Portugal)
2021/04/27 Pathogen-microbiome-host interactions in health and disease Programa Doutoral em Ciências Farmacêuticas 2020-21
Faculdade de Farmácia da Universidade de Coimbra (Coimbra, Portugal)
2021/03/16 The deadliest pathogens of all time Doctoral Programme in Experimental Biology and Biomedicine
Center for Neuroscience and Cell Biology, University of Coimbra (Coimbra, Portugal)
2021/03/15 Microbial diversity in the 4-domain Tree of Life: an infective overview Fighting Infection course, Doctoral Programme in Experimental Biology and Biomedicine
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2020/09/19 Mycobacteria: Complete biosynthesis of unique polysaccharides and the art of furtiveness 2nd CIBB Innovative Therapies Retreat 2020
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Universidade de Coimbra (Coimbra, Portugal)
2020/01/31 Distribution of mycobacterial polymethylated polysaccharides and their possible role in stress adaptation (Speaker: Ana Maranha) 2º Simpósio de Investigação em Tuberculose e Micobactérias não Tuberculosas em Portugal
Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2019/12/20 Parkinsons disease: a symptom of latent infection? (Speaker: Sandra M. Cardoso) CIBB Meeting 2019
Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra (Coimbra, Portugal)
2019/12/19 A novel mycobacterial pathway for biogenesis of rare lipid transfer polysaccharides implicated in cell envelope assembly CIBB Meeting 2019
Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra (Coimbra, Portugal)
2019/10/01 Polysaccharide biosynthesis vs recycling and replication in mycobacteria 7th Symposium on the Alpha-Amylase Family
Slovak Academy of Sciences (Smolenice, Slovakia)
2019/09/20 Unveiling mycobacterial methylmannose polysaccharide biosynthesis: a unique 1-O-methyltransferase specific for 3-O-methylated mannosides (Speaker: Jorge Ripoll-Rozada) MycoPORTO (Speaker: Jorge Ripoll-Rozada)
Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (Porto, Portugal)
2019/09/15 Cerveja: uma fonte de potenciais benefícios para a saúde do cérebro via microbioma intestinal Brew - Mesa Redonda: Saúde e Cerveja
Exploratório Ciência Viva (Coimbra, Portugal)
2019/06/07 A brave new world of gut microbiome-host interactions shaping health and disease 3as Jornadas de Cirurgia Colorectal (https://www.spcir.com/wp-content/uploads/2019/04/JORNADAS-DE-CIRURGIA-CR-ENTRE-LIS-E-TEJO-PROGRAMA-PRELIMINAR.pdf)
Centro Hospitalar de Leiria (Monte Real, Portugal)
2019/06/04 O papel do eixo intestino-cérebro na Doença de Parkinson (Speaker: Sandra M. Cardoso) IV Conference SANTA CASA Neurociências Um Olhar no Futuro" Longevidade e Doenças Neurodegenerativas
Santa Casa da Misericórdia de Lisboa, Pavilhão do Conhecimento, Centro Ciência Viva (Lisboa, Portugal)
2019/05/06 Doenças causadas por micobactérias: A tuberculose e outras muito sérias Centenário da Escola Secundária Gabriel Pereira 1919-2019
Escola Secundária Gabriel Pereira (Évora, Portugal)
2018/09/21 Molecular Mycobacteriology and the Microbiome in Communicable Diseases 9th EDCTP Forum: Clinical research and sustainable development in sub-Saharan Africa
European & Developing Countries Clinical Trials Partnership (EDCTP) Coimbra Hospital and University Center (CHUC) and University of Coimbra (UC) Health Science Campus (Coimbra, Portugal)
2018/06/18 Secrets of mycobacterial biology: de novo polysaccharide synthesis vs recycling & replication 1º Simpósio de Investigação em Tuberculose e Micobactérias não Tuberculosas em Portugal
Center for Neuroscience and Cell Biology, University of Coimbra (Coimbra, Portugal)
2018/05/17 The hidden microbiome in Parkinson's Disease (Speaker: Sandra M. Cardoso) 9th Annual World Congress NeuroTalk (Speaker: Sandra M. Cardoso)
BIT Group Global (Bangkok, Thailand)
2018/04/19 Pathways to stem the tide of TB drug resistance in the midst of a TB-Diabetes storm World Health Summit Regional Meeting 2018
University of Coimbra and Coimbra Hospital and Universitary Centre (CHUC) (Coimbra, Portugal)
2018/03/03 Viver com os micróbios: resistência a antibióticos e o microbioma humano MeetLab - II Encontro de Laboratório
Departamento Ciências da Vida, Universidade de Coimbra (Coimbra, Portugal)
2017/12/06 The gut microbiome in health and disease: key players and mechanisms PhD Program, Molecular Mechanisms of Disease
Faculdade de Medicina, Universidade de Coimbra (Coimbra, Portugal)
2017/04/07 Mycobacterial pathways from simple glycosides to fatty-acid shuttling polysaccharides Symposium Mycobacterium: Molecular Microbiology
National Center for Biotechnology, Universidad Autónoma de Madrid (Madrid, Spain)
2016/12/20 TB and not TB in the 21st century: a quest for new target-tailored precision antibiotics 1st Meeting on Biomedical Research @ UC
Universidade de Coimbra (Coimbra, Portugal)
2016/10/14 Como erguer uma parede impermeável: novas pistas no genoma de Mycobacterium tuberculosis VII Congresso Nacional da Fundação Portuguesa do Pulmão
Fundação Portuguesa do Pulmão (Lisboa, Portugal)
2016/07/06 Decrypting a vital pathway of Mycobacterium tuberculosis: towards new intervention strategies Ciência 2016 - Encontro com a Ciência e Tecnologia em Portugal
Fundação para a Ciência e a Tecnologia, Centro de Congressos de Lisboa (Lisboa, Portugal)
2016/06/23 Pathway for synthesis of methylglucose lipopolysaccharide in Mycobacterium tuberculosis The 2016 TB Summit
The Royal Society of Chemistry (London, United Kingdom)
2015/06/05 Exposing cryptic mycobacterial pathways: leaving no enzyme behind Friday Seminars at IBMC
Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto (Porto, Portugal)
2015/05/07 O microbioma humano e a resistência a antibióticos num planeta de micróbios Jornadas de Química e Bioquímica, Universidade da Beira Interior
Universidade da Beira Interior (Covilhã, Portugal)
2015/04/28 O combate à tuberculose: novos intermediários metabólicos essenciais Brokerage Event INESPO II (Speaker: Ana Maranha)
Divisão de Inovação e Transferências do Saber (DITS) (Coimbra, Portugal)
2015/01/27 Mycobacterial resistance to old antibiotics and potential biosynthetic pathways for new ones IC2AR, 1st International Caparica Conference in Antibiotic Resistance
Universidade NOVA de Lisboa (Speaker: Daniela Nunes-Costa) (Caparica, Portugal)
2015/01/26 Exposing new mycobacterial drug targets from unique metabolic pathways IC2AR, 1st International Caparica Conference in Antibiotic Resistance
Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa (Caparica, Portugal)
2014/12/15 When microbes get on your nerves Annual Meeting of the Center for Neuroscience and Cell Biology
Universidade de Coimbra (Coimbra, Portugal)
2013/02/08 Reconstructing mycobacterial pathways from missing enzyme links: playing hide and seek Winter CNC.IBILI Seminars
Center for Neuroscience and Cell Biology (CNC) (Coimbra, Portugal)
2013/01/26 Civilização: o paraíso das micobactérias Seminars at Instituto de Educação e Cidadania
Instituto de Educação e Cidadania (Mamarrosa, Portugal)
2012/07/25 Missing links in mycobacterial MGLP biosynthesis: the early players Seminars at the Department of Biochemistry, University of Cambridge
Department of Biochemistry, Sanger Building, University of Cambridge (Cambridge, United Kingdom)
2010/09/24 O planeta das micobactérias Palestras no Museu da Ciência
Museu da Ciência da Universidade de Coimbra (Coimbra, Portugal)
2010/03/24 Biossíntese de polissacáridos raros em Mycobacterium (Dia Mundial da Tuberculose) Feira de Ciência e Tecnologia
Faculdade de Ciências e Tecnologia, Universidade de Coimbra (Coimbra, Portugal)
2008/12/16 Biosynthesis of MGLP in Mycobacterium tuberculosis. Identification of genes and characterization of enzymes 6th Annual Meeting of the Center for Neuroscience and Cell Biology (Speaker: Vitor Mendes)
Fundação Bissaya-Barreto (Coimbra, Portugal)
2008/12/12 Compatible solutes in thermophiles and hyperthermophiles (Speaker: Milton Costa) Stress Responses in the Microbial World
Belgian Society for Microbiology (Brussels, Belgium)
2008/03/24 A caminho de um novo antibiótico (Dia Mundial da Tuberculose) Semana da Tuberculose
Associação Nacional de Tuberculose e Doenças Respiratórias (Lisboa, Portugal)
2007/09/03 Biosynthesis and accumulation of compatible solutes in hyper/thermophiles Halophiles 2007 - 8th International Congress Exploring Life at High Salinity
University of Essex (Colchester, United Kingdom)
2007/06/01 The accumulation and biosynthesis of compatible solutes in thermophiles and hyperthermophiles (Speaker: Milton Costa) VII Congrés de la Société Française de Microbiologie
Société Française de Microbiologie (Nantes, France)
2006/09/20 Rubrobacter xylanophilus MpgS. Evolution of MG and GG biosynthesis in prokaryotes "Extremophiles 2006", International Conference on Extremophiles
International Society for Extremophiles (Brest, France)
2006/05/22 The mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus "HotSolutes" Final Meeting
Instituto de Tecnologia Química e Biológica (ITQB) (Carcavelos, Portugal)
2004/10/15 Biosynthesis of glucosylglycerate: a "coldsolute" from prokaryotes 3rd "HotSolutes" Meeting
Universita Degli Studi di Ferrara (Ferrara, Italy)
2004/09/25 Nature's shields to environmental stress: biosynthesis of compatible solutes in extremophiles 2nd Annual Meeting of the Center for Neuroscience and Cell Biology
Center for Neuroscience and Cell Biology (Luso, Portugal)
2004/02/27 Optimizing mannosylglycerate production by Saccharomyces cerevisiae 1st "HotSolutes" Meeting
Instituto de Tecnologia Química e Biológica (ITQB) (Carcavelos, Portugal)
2003/11/21 Production of mannosylglycerate by Saccharomyces cerevisiae 6th "Hypersolutes" Meeting
Technische Universtität Hamburg (Hamburgo, Germany)
2003/03/08 Production of mannosylglycerate in mesophilic organisms 5th "Hypersolutes" Meeting
Instituto de Tecnologia Química e Biológica (Alcochete, Portugal)
2002/03/01 Synthesis of mannosylglycerate at room temperature: properties of a mesophilic mannosylglycerate synthase 3rd "Hypersolutes" Meeting
Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2001/10/23 Genes for the synthesis of mannosylglycerate at high and room temperature: characterization of key-enzymes 2nd "Hypersolues" Meeting
Universitaet Konstanz (Konstanz, Germany)
2001/07/02 Biosynthesis of mannosylglycerate in the hyperthermophile Pyrococcus horikoshii: characterization of key-enzymes 27th FEBS Meeting
Federation of European Biochemical Societies (Lisboa, Portugal)
2001/02/10 Mannosylglycerate biosynthesis in Pyrococcus horikoshii: characterization of key-enzymes 1st "Hypersolutes" Meeting
Instituto de Tecnologia Química e Biológica (ITQB) (Oeiras, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - Current Novos diterpenóides semi-sintéticos para o tratamento de infeções resistentes
Co-supervisor of Olha Antoniuk
 Ciências Farmacêuticas (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2021 - Current Unveiling the role of gut dysbiosis in Schizophrenia pathology
Co-supervisor of Ana Raquel Santos
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra, Portugal
2020 - Current Impact of the gut microbiome in the immune modulation of TB infection
Supervisor of Inês Cravo Roxo
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra, Portugal
2023 - 2024 Activation of innate immunity in macrophages by nontuberculous mycobacteria
Co-supervisor
 Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019 - 2024 The impact of bacterial infection in gut first Parkinson’s Disease: the influence of innate immunity activation in alpha-Synuclein expression and mitochondrial dysfunction
Co-supervisor of João Duarte Magalhães
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2022 - 2023 Conflicting interactions between methylobacteria and mycobacteria from drinking water
Co-supervisor of Ana Afonso Dias
 Microbiologia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022 - 2023 Profiling mycobacteria isolated from the houses of patients with NTM disease
Co-supervisor of Maria Carolina Fernandes
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017 - 2022 Biochemical and structural studies of a novel glucosamine kinase and a unique glycosyltransferase: New antimicrobial opportunities in actinobacterial glycobiology
Supervisor of Daniela Cristina Nunes Costa
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra, Portugal
2020 - 2021 Biosynthesis of serotonin in bacteria: an exploratory study
Supervisor of Sara Miguel Gonçalves
 Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2020 - 2021 Identification of NTM proteins involved in cell aggregation and biofilm formation
Co-supervisor of Ana Rita Fonseca
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2019 Esterilização supercrítica de aerogéis compostos por polímeros naturais para aplicações biomédicas
Co-supervisor of Cristiana Amaral Bento
 Engenharia Química (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015 - 2019 Mycobacterial methylmannose polysaccharides’ biosynthesis
Supervisor of Maria Mafalda Santos Costa
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2018 - 2018 Antimicrobial susceptibility and competition of diabetic skin microbiota
Co-supervisor of Antonella DiCaro
 Erasmus+ Programme (Specialization course)
Università degli Studi del Sannio, Italy
2016 - 2018 Deciphering microbiome signatures in chronic diseases
Supervisor of Ana Branco Maranha Tiago
 Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015 - 2018 Functional & structural studies of potential targets of mycobacterial pathways
Co-supervisor of Jorge Ripoll Rozada
Pós-Doutoramento
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2015 - 2018 Defining the missing links in mycobacterial methylglucose lipopolysaccharide biosynthesis
Supervisor of Susana Isabel Elias Alarico
 Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014 - 2018 Biochemical and structural characterization of mycobacterial drug targets
Co-supervisor of Tatiana Barros Reis Cereija
 Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2017 Isolation of ESKAPE pathogens from diabetic wounds
Co-supervisor of Pau Porras Socias
 Biotechnology (Erasmus+ Programme) (Master)
Universitat de Barcelona Facultat de Biologia, Spain
2015 - 2016 Avaliação do potencial antimicrobiano e síntese de glucosilglicerato em streptacidiphilus jiangxiensis sob diferentes condições de stress
Supervisor of Cristina Isabel da Silva Martins
 Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2015 - 2016 Colesterol oxidase, hormonas sexuais e suscetibilidade à tuberculose : um estudo exploratório
Supervisor of Ana Catarina Silva Monteiro
 Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 - 2016 Molecular and biochemical studies of a mycobacterial maltokinase and a unique octanoyltransferase: Towards reconstruction of the pathway for methylglucose lipopolysaccharides biosynthesis
Supervisor of Ana Branco Maranha Tiago
 Biociências (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2015 Molecular and biochemical characterization of a rare glucokinase with a cryptic function in environmental mycobacteria
Supervisor of Daniela Cristina Nunes Costa
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 - 2015 Molecular and physiological characterization of two crucial enzymes from M. tuberculosis
Supervisor of Vitor Gonçalo Costa Mendes
 Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012 - 2015 The early steps in methylglucose lipopolysaccharide biosynthesis in mycobacteria
Supervisor of Susana Isabel Elias Alarico
 Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2014 Perfis de resistência a antimicrobianos de estirpes de Mycobacterium isoladas de ambiente hospitalar
Supervisor of Diogo José Pereira Reis
 Biotecnologia dos Recursos Marinhos (Master)
Instituto Politécnico de Leiria, Portugal
2012 - 2013 Biosynthesis of rare methylglucose lipopolysaccharides in rapidly-growing mycobacteria : characterization of a key hydrolase
Supervisor of Maria Mafalda Santos Costa
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011 - 2012 Análise funcional de maltocinases e trealose sintases/maltocinases bifuncionais
Supervisor of Andreia Filipa Nisa Mendes Lamaroso
Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2012 Deciphering the regulatory mechanisms controlling compatible solutes biosynthesis in Thermus thermophilus osmo- and thermoadaptation
Supervisor of Susana Isabel Elias Alarico
 Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007 - 2011 New insights into the biosynthesis of the mycobacterial methylglucose lipopolysaccharide
Supervisor of Vitor Gonçalo Silva e Costa Mendes
 Bioquímica / Especialidade Microbiologia (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2010 A multifactorial approach to the biological role of the mycobacterial maltokinase
Supervisor of Ana Branco Maranha Tiago
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2009 Relevance of MG and trehalose in the osmoadaptation of Thermus thermophilus
Co-supervisor of Susana Isabel Elias Alarico
 Biologia / Especialidade Microbiologia (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2009 Osmotic and thermal adaptation in ancient thermophilic bacteria : biosynthesis of glucosyglycerate and mannosylglucosylglycerate
Co-supervisor of Chantal Ana Vicência Fernandes
 Bioquímica / Especialidade Microbiologia (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/05/15 - 2024/05/16 "BEB Day 2024 - (Not) Knowing What Comes Next". Coordinators: Nuno Empadinhas & John Jones; Organizing Committee: Alejandra Nunez, Carolina Mendes, Luísa Matos, Sofia Figueira, Beatriz Ribeiro, Emanuel Tahiri, Inês Moniz, João Gabriel Silva, Laura Carvalho, Mariana Diniz, Sara Martins, Simão Santos, Solange Martins. https://cnc.uc.pt/en/dia-do-beb-2024 (2024/05/15 - 2024/05/16)
Symposium
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2024/01/15 - 2024/01/17 7th Iberian Carbohydrate Meeting (https://www.iberiancarbohydrate2024.com/index.php/organizers) (2024/01/15 - 2024/01/17)
Conference (Member of the Organising Committee)
 Carbohydrate Group of the Real Sociedad Española de Química (RSEQ), Spain

Grupo dos Glúcidos da Sociedade Portuguesa de Química, Portugal
2023/02/07 - 2023/02/08 "BEB Day 2023 - Science Challenges". Coordinator: Nuno Empadinhas; Organizing Committee: Ana Vasconcelos, Débora Mena, Frederico Pena, João Novo, Maria Inês Cristo, Rafaela Ferrão. https://www.uc.pt/iii/agenda-ensino-iiiuc/beb-day-2023/ (2023/02/07 - 2023/02/08)
Symposium (Member of the Organising Committee)
 Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal
2022/01/18 - 2022/01/19 "BEB Day 2022 - The Overview Effect" Coordinator: Nuno Empadinhas. Organizing Committee: Carlos Barreto, Inês Caramelo, Inês Roxo, Luís Grilo, Maria Alfaiate, Mariana Magalhães, Raquel Santos, Rita Santos. https://www.uc.pt/en/iii/bebday/bebday2022/ (2022/01/18 - 2022/01/19)
Symposium (Member of the Scientific Committee)
 Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal
2021/09/17 - 2021/09/17 "3rd Retreat CIBB Innovative Therapies" Organizing Committee: Nuno Empadinhas, Irina Moreira, Hugo Fernandes. (2021/09/17 - 2021/09/17)
Meeting (Co-organisor)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/04/05 - 2019/04/05 "Mycobacterial Glycoimmunology Joint Meeting 2019". Organizers/Participants: Nuno Empadinhas, Margarida Correia Neves, Gunilla Kallenius, Chritopher Sundling, Susana Alarico, Ana Maranha, Mafalda Costa, Daniela Costa. (2019/04/05 - 2019/04/05)
Meeting (Co-organisor)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/12/07 - 2018/12/07 "1st Microbiome-Gut-Brain Axis Joint Meeting". Organizers: Nuno Empadinhas & Sandra M. Cardoso. (2018 - 2018)
Meeting (Co-organisor)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/06/18 - 2018/06/18 "1º Simpósio de Investigação em Tuberculose e Micobactérias Não Tuberculosas em Portugal" Chair: Nuno Empadinhas. Scientific Committee: Raquel Duarte, Margarida Correia-Neves, Miguel Viveiros. Organizing Committee: Mafalda Costa, Ana Maranha, Susana Alarico, Daniela Costa, John D. Marugg, Olena Radomska. (2018/06/18 - 2018/06/18)
Symposium (President of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Minho Escola de Medicina, Portugal

Universidade do Porto Instituto de Saúde Pública, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/03/25 Impact of Nutrition on Gut Microbiota: Implications to Parkinson's Disease
(Thesis) Main arguer
 Joana Rocha Sobral (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2024/03/18 Deciphering unexploited features of drug-repurposing beta-lactams against tuberculosis: from genomic patterns of Mycobacterium tuberculosis susceptibility to synergistic combinations
(Thesis) Main arguer
 Francisco Olivença Miguel (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/01/30 Staphylococcus aureus intracellular lifestyle: phenotypic profiles and underlying molecular determinants
(Thesis) Arguer
 Inês Rodrigues Lopes (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2023/09/27 The role of micronutrients in unconventional T cells: How RA-signalling controls iNKT cells development
(Thesis) Main arguer
 Diogo Vieira da Silva (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/03/21 Biochemical and structural studies of a novel glucosamine kinase and a unique glycosyltransferase: New antimicrobial opportunities in actinobacterial glycobiology
Supervisor
 Daniela Cristina Nunes Costa (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2022/05/16 Enterobacteriaceae as mediators for carbapenems resistance transfer between environmental and human settings
(Thesis) Arguer
 Pedro Filipe de Sá Teixeira (PhD)
Universidade de Aveiro, Portugal
2021/11/30 Risk factors associated with multidrug-resistant tuberculosis transmission in Portugal
(Thesis) Main arguer
 Olena Radomska (PhD)
Universidade do Minho Escola de Medicina, Portugal
2020/12/16 Changes in the gut-brain axis during aging
(Thesis) Main arguer
 João Tomás Barros (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/09/07 Towards a better understanding of host cell requirements for Salmonella cytosolic replication
(Thesis) Main arguer
 Susana Santos Costa (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/07/22 Mycobacterial methylmannose polysaccharides’ biosynthesis
Supervisor
 Maria Mafalda Santos Costa (PhD)
Universidade de Coimbra, Portugal
2018/09/28 Novos materiais para a oxigenação melhorada de culturas de células e de scaffolds para engenharia de tecidos
(Thesis) Main arguer
 Mariana Hugo Silva (Master)
Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
2017/06/16 O papel do mitoribossoma na função mitocondrial: Implicações para a Doença de Parkinson
(Thesis) Main arguer
 Ana Mafalda Gonçalves (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/06/09 Unraveling the protection mechanisms in the radiation resistant bacterium Deinococcus radiodurans
(Thesis) Main arguer
 Sandra Isabel Santos (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/09/24 Avaliação do potencial antimicrobiano e síntese de glucosilglicerato em Streptacidiplilus jiangxiensis sob diferentes condições de stress
Supervisor
 Cristina Martins (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/09/23 Colesterol Oxidase, Hormonas Sexuais e Suscetibilidade à Tuberculose
Supervisor
 Ana Monteiro (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/07/25 A genomic exploration of transmissibility in Mycobacterium tuberculosis
(Thesis) Main arguer
 Hanna Nebenzahl Guimarães (PhD)
Universidade do Minho Escola de Medicina, Portugal
2016/01/13 Molecular and biochemical studies of a mycobacterial maltokinase and a unique octanoyltransferase: Towards reconstruction of the pathway for methylglucose lipopolysaccharides biosynthesis
Supervisor
 Ana Branco Maranha Tiago (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/07/17 Molecular characterization of Klebsiella pneumoniae beta-lactamases from patients with renal transplants admitted to the Coimbra University Hospital
(Thesis) Arguer
 Delfino Vubil (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015/07/17 Molecular and biochemical characterization of a rare glucokinase with a cryptic function in environmental mycobacteria
Supervisor
 Daniela Cristina Nunes Costa (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015/07/13 Characterizing Iron Transporters in Plasmodium species
(Thesis) Main arguer
 Aparajita Lahree (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2014/11/26 New Retroviral-Like Membrane-Associated Aspartic Proteases from Rickettsiae: Biochemical Characterization and Specificity Profiling
(Thesis) Arguer
 Rui Gonçalo Cruz (PhD)
Universidade de Coimbra, Portugal
2014/11/07 Fe/S Cluster Biogenesis Regulation by the Janus-faced Regulator, IscR: An Unforeseen Mechanism of DNA Recognition and Discrimination
(Thesis) Arguer
 Joana Abreu Santos (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/10/29 Perfis de resistência a agentes antimicrobianos de 5 estirpes do género Mycobacterium isoladas de ambiente hospitalar
Supervisor
 Diogo Reis (Master)
Instituto Politécnico de Leiria, Portugal
2013/10/31 Diversity of arsenite transporter genes in microbial populations of the abandoned uranium mine in Urgeiriça
(Thesis) Main arguer
 Rui Marques Costa (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/09/20 Screening of Saccharomyces cerevisiae strains for recombinant protein expression
(Thesis) Main arguer
 Paulo Espírito Santo (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/07/12 Biosynthesis of methylglucose lipopolysaccharides in rapidly growing mycobacteria: characterization of a key hydrolase
Supervisor
 Mafalda Santos Costa (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/09/07 Analysis of the antimicrobial content of amphibian skin secretions and structural and functional characterization of a novel member of the temporin family (temporin-SHe)
(Thesis) Main arguer
 Sónia Costa André (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/09/06 Análise functional de maltocinases e trealose sintases/maltocinases bifuncionais
Supervisor
 Andreia Mendes Lamaroso (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/06/04 The Adaptive Response of Mycobacterium avium to Anoxia and Nitric Oxide
(Thesis) Main arguer
 John Edward Pearl (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012/05/11 Structure-function Relationships in a Glycosyltransferase, a Phosphatase and an Oxidoreductase
(Thesis) Arguer
 Susana Pires Gonçalves (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011/12/09 New Insights into the Biosynthesis of the Mycobacterial Methylglucose Lipopolysaccharide
Supervisor
 Vitor Gonçalo Silva Costa Mendes (PhD)
Universidade de Coimbra, Portugal
2011/09/19 Estratificação vertical das comunidades microbianas da zona mesopelágica, no Atlântico Norte, determinada por pirosequenciação do 16S DNAr
(Thesis) Main arguer
 Luísa Silva Lopes (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/07/19 Characterization of bacterial strains resistant to uranium for use in bioremediation
(Thesis) Main arguer
 Tânia Miranda Sousa (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/04/01 Formation and analysis of metal-induced phosphate rich extracellular nano-particulate in the Cr(VI) resistant strain Ochrobactrum tritici 5bv11
(Thesis) Main arguer
 Pedro Miguel Abreu (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2010/09/10 Evolução molecular dos genes pilD e lspE de Legionella pneumophila
(Thesis) Main arguer
 Ana Filipa d’Avó (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2010/09/09 A multifactorial approach to the biological role of the mycobacterial maltokinase
Supervisor
 Ana Branco Maranha Tiago (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2009/07/24 Osmotic and Thermal adaptation in ancient thermophilic bacteria. Glucosylglycerate and mannosylglucosylglycerate
Supervisor
 Chantal Vicência Fernandes (PhD)
Universidade de Coimbra, Portugal
2009/03/30 Relevance of Mannosylglycerate and Trehalose Accumulation in the Osmoadaptation of Thermus thermophilus
Supervisor
 Susana Isabel Elias Alarico (PhD)
Universidade de Coimbra, Portugal
2008/09/30 Role of Hsp60 and its peptide aa437-460 in experimental Sjogren’s syndrome
(Thesis) Arguer
 Ana Carina Madureira (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Association member

Society Organization name Role
2023 - Current SPQ - Sociedade Portuguesa de Química
2018 - Current ASM – American Society for Microbiology
2014 - Current NTM-NET
2014 - Current TBnet
2013 - Current ESM - European Society of Mycobacteriology
2006 - 2016 SPM - Sociedade Portuguesa de Microbiologia

Committee member

Activity description
Role 		Institution / Organization
2021 - Current Associate Editor "Biologia" (Cellular and Molecular Biology) (1336-9563)
Member
 Springer Nature Switzerland AG, Switzerland
2021 - Current Advanced Studies Office Board Member
Member
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020 - Current Associate Editor of "BMC Microbiology" (Microbial Biochemistry, Physiology and Metabolism)
Member
 BioMed Central Ltd, United Kingdom
2020 - Current Editorial Board of "Antibiotics" (Antibiotic Biosynthesis' Section) (2079-6382)
Member
 Multidisciplinary Digital Publishing Institute AG, Switzerland
2019 - 2020 Guest Associate Editor of "Frontiers in Immunology" (Nutritional Immunology) (1664-3224)
Member
 Frontiers Media SA, Switzerland
2016 - 2019 Coordinator CNC.IBILI Seminars Program - Center for Neuroscience and Cell Biology
Coordinator
 CNC.IBILI, Portugal
2015 - 2018 Editorial Board of "Scientific Reports" (2045-2322)
Member
 Springer Nature Limited, United Kingdom

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - 2024 Invited lecturer, "Micobactérias Não Tuberculosas" course (Coordinator: Raquel Duarte) (Especialização pós-licenciatura) Universidade do Porto Instituto de Saúde Pública, Portugal
2015 - 2024 Invited lecturer, "Biology of Ageing" course, Masters in Biomedical Engineering (Coordinator: Sandra M. Cardoso) Biologia do Envelhecimento (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2015 - 2024 Invited lecturer, "Aging" course, Masters in Cell and Molecular Biology (Coordinator: Emília Duarte) Biologia Celular e Molecular (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/02/17 - 2023/03/10 Invited lecturer, "Bacteriologia Clínica" course (Coordinator: Nádia Osório) Bacteriologia Clínica (Pós-Graduação) Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2021 - 2023 Invited lecturer, "Tuberculose" course (Coordinator: Raquel Duarte) (Especialização pós-licenciatura) Universidade do Porto Instituto de Saúde Pública, Portugal
2021 - 2022 Invited lecturer, "Doutoramento em Ciências Farmacêuticas" (Coordinators: João Laranjinha) Ciências Farmacêuticas (Doutoramento) Universidade de Coimbra Faculdade de Farmácia, Portugal
2018 - 2021 Course "Fighting Infection" of the PhD Programme in Experimental Biology and Biomedicine (Coordinators: Nuno Empadinhas, Susana Alarico, Isaura Simões) PhD Programme in Experimental Biology and Biomedicine (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019 - 2019 Invited lecturer, "Química Farmacêutica II" (Coordinator: Maria Manuel Silva) Ciências Farmacêuticas (Mestrado integrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2019 Invited lecturer, "Tecnologia de Produção de Vacinas" (Coordinator: Olga Borges) Ciências Farmacêuticas (Mestrado integrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2019 Invited lecturer, "Biologia Translacional e Biomedicina" (Coordinator: João Ramalho Santos) Biologia (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013 - 2015 Course "Microbiologia e o Microbioma Humano", Instituto de Educação e Cidadania (IEC) (Coordinators: Nuno Empadinhas & Susana Alarico) (Ensino secundário) Instituto de Educação e Cidadania (IEC), Portugal
2012 - 2012 Course "Medical Microbiology" of the PhD Programme in Experimental Biology and Biomedicine (Coordination: Medical Microbiology Group) (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012 - 2012 Invited lecturer, "Microbiologia e Parasitologia", Masters in Public Health (Coordinator: Teresa Gonçalves) Saúde Pública (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2008 - 2011 Molecular Microbiology (Masters in Biochemistry) Masters in Biochemistry (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2008 - 2011 Microbiology (Degree in Biochemistry) Bioquímica (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2006 - 2011 Course "Microbiology" of the PhD Programme in Experimental Biology and Biomedicine (Coordinators: Nuno Empadinhas & Milton da Costa) PhD Programme in Experimental Biology and Biomedicine (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2002 - 2007 Invited lecturer, "Microbiologia" (Coordinator: Milton da Costa) Bioquímica (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2005 - 2005 Course "Microbiology of Extreme Environments" of the PhD Programme in Experimental Biology and Biomedicine (Coordinators: Milton da Costa & Nuno Empadinhas) PhD Programme in Experimental Biology and Biomedicine (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2002 - 2003 Invited lecturer, "Evolução e Biodiversidade" (Coordinator: Milton da Costa) Biologia (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2023 - Current ANR Grants, Cellular Biology, Developmental Biology and Evolution
Evaluator
 Agence nationale de la recherche, France Agence nationale de la recherche
2024 - 2024 ERA-NET NEURON
Evaluator
 Fundación Española para la Ciencia y la Tecnología, Spain ERA-Net Cofund scheme
2019 - 2023 FCT Final Grant Reports, Panel Experimental Biology and Biochemistry
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2021 - 2021 Innovate Competition, iMed Conference® 13.0 - Lisbon 2021, Jury A
Evaluator
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal AstraZeneca Foundation
2019 - 2020 REWIRE - Reinforcing Women in Research (https://rewire.univie.ac.at/)
Evaluator
 University of Vienna, Austria, Austria COFUND Programme, Marie Sklodowska Curie Actions COFUND Project, European Commission
2015 - 2015 ANR Grants, Panel Immunology and Infection
Evaluator
 Agence nationale de la recherche, France Agence nationale de la recherche
2014 - 2014 Health and Medical Research Fund, Final Grant Reports
Evaluator
 Health and Medical Research Fund, The Government of the Hong Kong Special Administrative Region, Hong Kong SAR China Health and Medical Research Fund, The Government of the Hong Kong Special Administrative Region

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2024/03/27 Ciclo de conferências "Microbioma Humano", Academia das Ciências de Lisboa https://www.dn.pt/5794656047/nuno-empadinhas-podemos-entrar-numa-era-pos-antibiotico-em-que-deixaremos-de-poder-contar-com-estes/ Diário de Notícias
2020/06/01 Editor's Choice May 2020: Understanding a Mycobacterial Thermophile https://microbiologysociety.org/blog/microbiology-editor-s-choice-understanding-a-mycobacterial-thermophile.html Microbiology Society UK
2019/03/24 Viagens na Tuberculose - Banda desenhada comemorativa do Dia Mundial da Luta Contra a Tuberculose https://www.publico.pt/2019/03/24/ciencia/noticia/boicote-parede-derrubar-tuberculose-1866484 Público

Interview (tv / radio show)

Program Topic
2022/03/18 - 2022/03/18 Rádio TSF Noticiário Thiomargarita magnífica: descoberta uma bactéria colossal
2021/10/13 - 2021/10/13 A Saúde no Saber Microbiologia e Doenças Infeciosas
2019/03/03 - 2019/03/03 Ciência aos Domingos Doenças causadas por micobactérias, da Tuberculose às infecções pulmonares atípicas
2016/12/02 - 2016/12/02 SIC - Jornal da Noite Prémio Santa Casa Neurociências Mantero Belard
2015/12/10 - 2015/12/10 RTP 1 - Jornal da Tarde Descoberta de enzima essencial de Mycobacterium tuberculosis
2015/10/21 - 2015/10/21 Bolsas de Ignição Produção de compostos essenciais para investigação em doenças causadas por micobactérias
2009/10/02 - 2009/10/02 TVI - Jornal da Uma Micróbio resistente a radiações

Journal scientific committee

Journal title (ISSN) Publisher
2021 - Current Neurotoxicity Research (Ad hoc reviewer) (1029-8428) Springer
2021 - Current Pulmunology (Ad hoc reviewer) (2531-0437) Elsevier
2020 - Current European Journal of Clinical Investigation (Ad hoc reviewer) (1365-2362) Wiley (Blackwell Publishing)
2020 - Current Microorganisms (Ad hoc reviewer) (2076-2607) MDPI AG
2020 - Current Neuropsychiatric Disease and Treatment (Ad hoc reviewer) (1176-6328) Dove Medical Press
2017 - Current Clinical Medicine Insights Circulatory Respiratory and Pulmonary Medicine (Ad hoc reviewer) (1179-5484) "Libertas Academica, Ltd."
2016 - Current Archaea (Ad hoc reviewer) (1472-3654) Hindawi Limited
2015 - Current PLoS ONE (Ad hoc reviewer) (1932-6203) Public Library of Science
2015 - Current Scientific Reports (Ad hoc Reviewer) (2045-2322) Nature
2014 - Current Biochimica et Biophysica Acta (BBA) - General Subjects (Ad hoc reviewer) (0304-4165) Elsevier
2014 - Current Frontiers in Molecular Biosciences (Ad hoc reviewer) (2296-889X) Frontiers Media SA
2014 - Current Microbial Drug Resistance (Ad hoc reviewer) (1931-8448) Mary Ann Liebert
2014 - Current World Journal of Microbiology and Biotechnology (Ad hoc reviewer) (1573-0972) Springer-Verlag
2013 - Current Tuberculosis (Ad hoc reviewer) (1472-9792) Elsevier
2012 - Current Folia Microbiologica (Ad hoc reviewer) (1874-9356) Springer-Verlag
2011 - Current Applied Microbiology and Biotechnology (Ad hoc reviewer) (1432-0614) Springer-Verlag
2010 - Current BMC Genomics (Ad hoc reviewer) (1471-2164) Springer (Biomed Central Ltd.)
2010 - Current Enzyme and Microbial Technology (Ad hoc reviewer) (0141-0229) Elsevier
2010 - Current Marine Drugs (Ad hoc reviewer) (1660-3397) MDPI AG
2010 - Current Research in Microbiology (Ad hoc reviewer) (0923-2508) Elsevier
2008 - Current Extremophiles (Ad hoc reviewer) (1433-4909) Springer-Verlag
2008 - Current Journal of Bacteriology (Ad hoc reviewer) (1098-5530) American Society for Microbiology

Other jury / evaluation

Activity description Institution / Organization
2021/07/20 - Current Ana Isabel Gonçalves Roque, "Blood microbiome: insights into gut barrier function and autoimmunity development in Celiac Disease" - Projecto de Tese e Comissão de Acompanhamento de Tese (CAT), Programa Doutoral em Biologia, Universidade Nova de Lisboa Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/11/25 - 2022/11/25 Teresa Paula Marques "Impacto da Microbiota Oral e Intestinal na Infeção Covid-19" Relatório de Ano Probatório do Doutoramento em Ciências Biomédicas do Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto. Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/11/10 - 2015/11/10 André Lázaro Correia "Bariatric surgery and gut microbiome shifts: is there a difference between gastric sleeve and gastric bypass?", Projecto de Tese, Programa de Doutoramento em Ciências da Saúde, Faculdade de Medicina, Universidade de Coimbra Universidade de Coimbra Faculdade de Medicina, Portugal
2015/07/16 - 2015/07/16 Pedro Curto "The retropepsin-like enzyme RC1339/APRc from Rickettsiae as a potential therapeutic target for rickettsial diseases", Thesis Project, PhD Programme in Experimental Biology and Biomedicine (PDBEB), Center for Neuroscience and Cell Biology, University of Coimbra. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Scientific expedition

Activity description Institution / Organization
2018/06 - 2018/10 Expedition "Domestic NTM - There must be something in the water". Organization and sampling: Nuno Empadinhas, Susana Alarico, Daniela Machado. Coimbra/Aveiro/Braga/Porto Districts. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Instituto de Saúde Pública, Portugal
2008/10/23 - 2008/10/25 Expedition "Furnas - Novel thermophiles". Organization: Nuno Empadinhas & Milton S. da Costa. Sampling: Nuno Empadinhas & Sandra M. Cardoso. Furnas, São Miguel Island, Azores Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2004/09/04 - 2004/09/09 Expedition "Hotspots - Isolation of thermophiles from Azorean Hotsprings for biotechnological applications". Organization: Milton S. da Costa, Nuno Empadinhas, Garabed Antranikian. Sampling: Nuno Empadinhas, Ana Nobre, Rami Al-Khudary, Ksenia Egorova, Moritz Katzer, with technical support by the University of the Azores, Ponta Delgada Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Technische Universität Hamburg Studiendekanat Gewerblich-Technische Wissenschaften, Germany
1998/07/29 - 1998/08/03 Expedition "Keratin - New keratin-degrading thermophiles from hotsprings in São Miguel Island". Organization and sampling: Milton S. da Costa & Nuno Empadinhas, with technical support from the University of the Azores, Ponta Delgada, Azores Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade dos Açores, Portugal
Distinctions

Award

2023 Pfizer Award in Basic Research, awarded to Sandra M. Cardoso, Nuno Empadinhas and co-authors
Sociedade de Ciências Médicas de Lisboa & Pfizer, Portugal
2020 Prémio Projetos Semente de I&D "Era pós-COVID 19"
Universidade de Coimbra/Santander, Portugal
2017 Thomé Villar Award
Sociedade Portuguesa de Pneumologia, Portugal
2016 Santa Casa Neurociências Mantero Belard Award
Santa Casa da Misericórdia de Lisboa, Portugal
2012 Mizutani Grant - Exploratory Glycoscience
Mizutani Foundation for Glycoscience, Japan, Japan

Other distinction

2021 Article featuring the cover of "Antioxidants & Redox Signaling" (Volume 34, Issue 8, March)
Mary Ann Liebert, Inc., publishers, United States
2020 Editor's Choice Article selected for the May Issue of "Microbiology" (Volume 166, Issue 5)
Microbiology Society, United Kingdom
2011 Article featuring the cover of "Molecular Microbiology" (Volume 79, Issue 1, January 2011)
Molecular Microbiology Editorial Board (Wiley Blackwell Publishing), United States
2003 Travel Fellowship to the 1st FEMS Congress of European Microbiologists, Jun 29 - Jul 3, Ljubljana, Slovenia
Fundação Calouste Gulbenkian, Portugal
2002 Travel Fellowship to the 30th FEBS Congress: The Protein World, 2-7 July, Budapest, Hungary
Fundação Calouste Gulbenkian, Portugal