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I obtained my PhD in biomedicine in 2012 at the Medical Faculty of the University of Porto. I then trained as a postdoc at IPATIMUP as an FCT fellow, and since 2017, I have been leading an independent research line at i3S. My expertise in gastric cancer and E-cadherin mediated signaling is reflected in my track record of 56 peer-reviewed publications (5 senior and 12 first-authorships), 5 book chapters and an h-index of 28 (SCOPUS) with over 3200 citations. I was distinguished as one of the top 25 under-40 most promising researchers in Portugal (2018) and with the No Stomach for Cancer Award for Gastric Cancer Research (2017). I have made seminal contributions to the understanding of E-cadherin dysfunction and associated molecular mechanisms during gastric cancer progression (Gastric Cancer, 2022; J Infect Dis, 2022). I provided the first evidence that mutations affecting the signal peptide core block E-cadherin translation and delivery, leading to diffuse gastric cancer (Molecular Cancer, 2018). In alignment with my commitment to translate research findings into the clinics, I have developed two bioimaging approaches, which are part of the current pipeline to uncover the functional relevance of E-cadherin variants found in disease contexts (Scientific Reports, 2018 & 2016). My research has a striking impact in patient management, illustrated in my involvement in the establishment of clinical guidelines for Hereditary Diffuse Gastric Cancer since 2015 (Lancet Oncol, 2020). I collaborate with several groups worldwide through the International Gastric Cancer Consortium, for which I am responsible to assess the pathogenicity of E-cadherin variants. In this context, I was invited to present my most recent results in the last Consortium meeting (Porto, 2024). Of note, I was a contact reference and team member of the CDH1 Expert Working Group from ClinGen, a NIH-funded resource dedicated to define the clinical relevance of genetic variants. Currently, I supervise a team of two PhD students, a master student and a postdoctoral researcher, focusing on the study of cell-matrix dynamics. I have attracted funding - 310K as PI, 410K as co-PI and over 3.2M as team member - from FCT, the American Association of Patients with Hereditary Gastric Cancer No Stomach for Cancer, NIH, National Science Foundation (NSF - USA), The EU Framework Programme for Research and Innovation (Horizon 2020), Operational Programme for Competitiveness Factors (COMPETE) and Novartis. Further, I have secured my salary since 2009 through competitive individual funding calls. I am a young researcher, mother of two children (2013, 2017), with a strong multidisciplinary collaborative network and international recognition. In the past 10 years, I have participated in 23 international scientific meetings and workshops, and have been invited as grant expert reviewer, academic editor for the European Journal of Cancer Prevention, guest editor for Cancers, review editor in Frontiers in Gastroenterology and in Frontiers in Oncology, reviewer for 24 peer-reviewed journals, and member of the scientific committee in 2 national and 6 international scientific meetings. I am committed to disseminate my results and to contribute to scientific literacy by lecturing in PhD and Master graduate programs, and participating in outreach activities promoted by i3S and the social media.
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Identification

Personal identification

Full name
Joana Pinto de Figueiredo

Citation names

  • Figueiredo, Joana

Author identifiers

Ciência ID
C51C-148B-32B5
ORCID iD
0000-0002-1590-1974
Researcher Id
Publons ResearcherID J-7305-2013
Scopus Author Id
35083360700

Email addresses

  • jfigueiredo@i3s.up.pt (Professional)

Telephones

Fax
  • 225570799 (Professional)
Telephone
  • 225570700 (Professional)

Addresses

  • Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto. Rua Alfredo Allen 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Oncology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Intermediate (B1) Intermediate (B1) Beginner (A1)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2009/02/01 - 2012/12/13
Concluded
 PhD in Biomedicine (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal

VIB - Ghent University, Belgium
"The role of E-cadherin trafficking regulation in epithelial cancer progression" (THESIS/DISSERTATION)
 Approved with distinction
2001/09 - 2005/10
Concluded
 Applied Biology (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"Effects of XIAP downregultion by RNAi in the response of K562 leukemia cells to chemotherapeutical drugs" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2022/09/01 - Current Auxiliary Researcher (Research) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
(...)
2019/01/01 - 2022/08/31 Contracted Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/01/01 - 2018/12/31 Postdoc (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/01/01 - 2018/12/31 Postdoc (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2005/10/01 - 2009/02/28 Research Assistant (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Others

Category
Host institution 		Employer
2009/03/01 - 2012/12/13 PhD Graduate Student Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projects

Grant

Designation Funders
2023/01/01 - 2025/12/31 Cellular architecture deconstructed: Artificial Intelligence to predict cancer invasion (I-CARD)
2022.02665.PTDC
Co-Principal Investigator (Co-PI)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/02/01 - 2025/02/28 Nuclear biomarkers for predictive prognosis of hereditary diffuse gastric cancer (NICE)
NICE
Co-Principal Investigator (Co-PI)
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 No Stomach For Cancer
Concluded
2022/01/01 - 2023/10/31 Nuclear cues in invasive cancer: overriding E-cadherin dysfunction (E-SIGN)
EXPL/MED-ONC/0386/2021
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/07 - 2022/03/31 Oral facial congenital malformations and gastric cancer risk: a matter of E-cadherin-mediated cell-extracellular matrix adhesion (E-RISK)
PTDC/MED-GEN/30356/2017
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/12 - 2022/02 Mechano-dependent capture of Circulating Tumour Cells: a cell-ECM based approach coupled with cancer specific glycomarkers (CAPTURE)
PTDC/BTM-SAL/30383/2017
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017/07 - 2021/06 Today's Present, Tomorrow's Future on the study of germline E-Cadherin Missense Mutations: a step forward on providing informed genetic counseling to everyone
STOMACH
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 No Stomach For Cancer
Concluded
2016/01 - 2020/03 Sensing dysfunctional E-cadherin cells in gastric epithelia (SENSE)
Provided by PTCRIS: 138871
PTDC/BIM-ONC/0281/2014
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2016/05/01 - 2019/12/31 Advancing cancer research: From Basic knowledge to application
NORTE-01-0145-FEDER-000029
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2017/06 - 2019/01 Maintenance of Mechanical Tension for Normal Tissue Function Requires Intercellular Cooperation
1362922
Researcher
Boston University College of Engineering, United States
 National Science Foundation Directorate for Engineering
Ongoing
2015/06 - 2017/06 Today´s present, tomorrow´s future on the study of germline E-cadherin missense mutations
MISS
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 No Stomach For Cancer
Concluded
2013/06 - 2015/09 Mutant E-Cadherin and Novel Interactors in Cancer (MECANIC). The role of mutant E-cadherin-integrin-ECM crosstalk in gastric cancer
Provided by PTCRIS: 124283
PTDC/BIM-ONC/0171/2012
Post-doc
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2013/01 - 2015/06 Molecular mechanisms underlying cancer cell invasion in two cancer disease models, gastric and breast
NORTE-07-0124-FEDER-000022
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/06 - 2013/11 The role of Protein Quality Control in the regulation of E-cadherin and its relevance in cancer
Provided by PTCRIS: 104017
PTDC/SAUOBD/104017/2008
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2008/07 - 2011/12 MLK3, a new mutated gene in MSI colorectal cancer
Provided by PTCRIS: 68310
PTDC/SAU-OBD/68310/2006
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2007/11 - 2009/01 Exploring the role of E-cadherin trafficking deregulation in epithelial cancer progression.
Provided by PTCRIS: 64319
PTDC/SAUOBD/64319/2006
Research Fellow
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2006/01 - 2007/10 Biological role of Braf oncogene activation in human carcinogenesis
BRAF
Research Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Norvartis Farma - Portugal
Concluded
2005/02 - 2005/12 Validation of the role of XIAP in quimiotherapy resistance in acute myelogenous leukemia: different approach for a new treatment
XIAP
Research Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Associação Portuguesa Contra a Leucemia
Concluded

Contract

Designation Funders
2022/09/01 - Current Nuclear signatures: dictating the invasive capacity of hereditary gastric cancer
CEECINST/00056/2021
Principal investigator
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01 - 2022/08 Dissecting migration dynamics during epithelial closure: a new approach to decode the clinical spectrum of CDH1 germline mutations
RJEC/Ipatimup/2/16
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/01/01 - 2018/12/31 The role of E-cadherin-integrin-ECM crosstalk in gastric cancer
SFRH/BPD/87705/2012
Post-doc Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/02 - 2012/12 The role of E-cadherin trafficking regulation in epithelial cancer progression
SFRH/BD/43763/2008
PhD Student Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Pereira, Joana; Melo, Soraia; Carneiro, Patrícia; Fernandes, Maria Sofia; Figueiredo, Joana; Seruca, Raquel. "Revisiting the Biological and Clinical Impact of CDH1 Missense Variants". In Hereditary Gastric and Breast Cancer Syndrome, 79-97. Springer International Publishing, 2023.
    10.1007/978-3-031-21317-5_6
  2. Corso, Giovanni; Magnoni, Francesca; Trovato, Cristina; Girardi, Antonia; Seruca, Raquel; Figueiredo, Joana; Roviello, Franco. "Hereditary Gastric Cancer: A New Syndrome". In Gastric Cancer: the 25-year R-Evolution, edited by Giovanni de Manzoni; Franco Roviello, 37-50. Springer International Publishing, 2021.
    10.1007/978-3-030-73158-8_5
  3. Figueiredo, J; Ribeiro, AS; Mestre, T; Esménio, S; Fonseca, M; Paredes, J; Seruca, R; Sanches, JM. "Capturing quantitative features of protein expression from in situ fluorescence microscopic images of cancer cell populations". 279-297. CRC Press, 2017.
    Published
  4. Esménio, S; Figueiredo, J; Seruca, R; Sanches, JM. "E-cadherin radial distribution characterization for mutation detection purposes". In Pattern Recognition and Image Analysis. Springer, 2013.
    Published • 10.1007/978-3-642-38628-2_20
  5. Oliveira, Carla; Pinheiro, Hugo; Figueiredo, Joana; Seruca, Raquel; Carneiro, Fátima. "E-Cadherin Alterations in Hereditary Disorders with Emphasis on Hereditary Diffuse Gastric Cancer". In Progress in Molecular Biology and Translational Science, 337-359. Elsevier, 2013.
    10.1016/b978-0-12-394311-8.00015-7
  6. Figueiredo, Joana; Seruca, Raquel. "Germline Missense Mutants in Hereditary Diffuse Gastric Cancer". In Spotlight on Familial and Hereditary Gastric Cancer, 77-86. Springer Netherlands, 2013.
    10.1007/978-94-007-6570-2_7
Conference poster
  1. Melo S; Carvalho L; Pereira J; Sanches JM; Machado JC; Seruca R; Figueiredo J. "Cell extrusion singularities in the gastric epithelium: insights from E-cadherin dysfunction". Paper presented in 11th i3S Annual Meeting, Póvoa de Varzim, Portugal, 2024.
  2. Santos JP; Pereira J; Sanches JM; Machado JC; Figueiredo J. "E-cadherin dysfunction modulates structural properties of nuclei in gastric cancer cells". Paper presented in 37th Workshop of the European Helicobacter and Microbiota Study Group, Porto, Portugal, 2024.
  3. Melo S; Carvalho L; Pereira J; Sanches JM; Machado JC; Seruca R; Figueiredo, Joana. "Cell extrusion signatures in the gastric epithelium: a crosstalk between E-cadherin and Filamin A". Paper presented in 37th Workshop of the European Helicobacter and Microbiota Study Group, Porto, Portugal, 2024.
  4. Melo S; Carvalho L; Pereira J; Sanches JM; Seruca R; Figueiredo J. "E-cadherin and Filamin A interactions define cell extrusion signatures". Paper presented in 5th International Gastric Cancer Linkage Consortium (IGCLC) Meeting, Porto, Portugal, 2024.
  5. Santos JP; Pereira J; Sanches JM; Figueiredo J. "Nuclear morphometric features triggered by E-cadherin dysfunction". Paper presented in 17th IJUP - Young Research Meeting from the University of Porto, Porto, Portugal, 2024.
  6. Figueiredo, Joana; Pereira J; Ferreira RM; Carvalho L; Gonçalves M; Melo S; Carneiro P; et al. "Physical and biochemical nuclear signatures: a secret message underlying gastric cancer invasion". Paper presented in 36th Workshop of the European Helicobacter and Microbiota Study Group. Antwerp, Belgium, 2023.
  7. Vieira DF; Fernandes MS; Moreira AM; Figueiredo, Joana; Seruca R; Sanches JM. "Unraveling the cytoskeletal architecture of cancer cells: development of a novel computational approach". Paper presented in 2023 USA-Portugal Leaders in Cancer Research. Champalimaud Foundation, Lisbon, Portugal, 2023.
  8. Vieira DF; Fernandes MS; Moreira AM; Figueiredo, Joana; Seruca R; Sanches JM. "Unraveling the cytoskeletal architecture of cancer cells: development of a novel computational approach". Paper presented in LARSyS Annual Meeting. Lisbon, Portugal, 2023.
  9. Fernandes MS; Figueiredo, Joana; Vieira D; Melo S; Moreira AM; Sanches JM; Seruca R. "Unraveling new strategies for early detection of invasive cancer cells: a special focus on the nuclear and cytoskeletal architecture". Paper presented in American Association for Cancer Research Annual Meeting 2023. Orlando, FL, USA, 2023.
  10. Figueiredo J; Pereira J; Ferreira RM; Carvalho L; Gonçalves M; Melo S; Carneiro P; et al. "Nucleus positioning and composition dictate the invasion performance of E-cadherin mutant cells". Paper presented in American Association for Cancer Research Annual Meeting 2023. Orlando, FL, USA, 2023.
  11. Pereira J; Melo S; Maia A; de Klein A; Guilford P; Seruca R; Figueiredo J. "E-cadherin variants associated with distinct clinical spectra induce different migration and cell adhesion profiles". Paper presented in 4th National Meeting of Young Researchers in Oncology, Liga Portuguesa Contra o Cancro, Porto, Portugal, 2022.
  12. Ferreira RM; Figueiredo J; Pinto-Ribeiro I; Gullo I; Sgouras DN; Carreto L; Castro P; et al. "Helicobacter pylori activates Laminin gamma2 promoting survival and invasion of gastric epithelial cells with E-cadherin impairment". Paper presented in 5th ASPIC International Congress, IPO-Porto, Portugal, 2022.
  13. Melo S; Figueiredo J; Sanches JM; Seruca R. "Cell extrusion: a synergistic interaction between E-cadherin and Filamin A". Paper presented in 5th ASPIC International Congress, IPO-Porto, Portugal, 2022.
  14. Pereira J; Melo S; Maia A; de Klein A; Guilford P; Seruca R; Figueiredo J. "Motile and adhesive profiles of variants associated with distinct E-cadherin mediated disorders". Paper presented in 5th ASPIC International Congress, IPO-Porto, Portugal, 2022.
  15. Figueiredo J; Pereira J; Nunes AC; Ferreira RM; Gonçalves M; Melo S; Carneiro P; et al. "Nuclear signatures of an invasive cancer program triggered by E-cadherin dysfunction". Paper presented in 5th ASPIC International Congress, IPO-Porto, Portugal, 2022.
  16. Fernandes MS; Figueiredo J; Melo S; Vieira D; Moreira AM; Maia A; Sanches JM; Seruca R. "Unravelling new strategies for early detection of invasive cancer cells: a focus on the nuclear architecture dynamics". Paper presented in EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine, Seville, Spain, 2022.
  17. Melo S; Figueiredo J; Sanches JM; Seruca R. "Filamin A is critical regulator of the extrusive abilities mediated by E-cadherin dysfunction". Paper presented in EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine, Seville, Spain, 2022.
  18. Pereira J; Melo S; Maia A; de Klein A; Guilford P; Seruca R; Figueiredo J. "E-cadherin variants associated with distinct clinical phenotypes induce distinct motile and adhesive profiles". Paper presented in EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine, Seville, Spain, 2022.
  19. Figueiredo J; Pereira J; Nunes AC; Ferreira RM; Gonçalves M; Melo S; Carneiro P; et al. "E-cadherin mutations induce remodeling of nucleus positioning and composition towards an invasive cancer program". Paper presented in EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine, Seville, Spain, 2022.
  20. Ferreira RM; Figueiredo J; Pinto-Ribeiro I; Gullo I; Sgouras DN; Carreto L; Castro P; et al. "Helicobacter pylori activates Laminin gamma2 promoting invasion and survival of gastric cancer cells with E-cadherin defects". Paper presented in 28th Porto Cancer Meeting - Extracellular Vesicles, Cell Communication and Cancer, i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal, 2022.
  21. Pereira J; Melo S; Maia AF; de Klein A; Guilford P; Seruca R; Figueiredo J. "Motile and adhesive signatures of E-cadherin variants associated with distinct clinical phenotypes". Paper presented in 4th PhDay - BREAK BORDERS, BUILD OPPORTUNITIES, 2021.
  22. Pereira J; de Klein A; Guilford P; Seruca R; Figueiredo J. "Cell migration patterns are associated with distinct E-cadherin mediated disorders". Paper presented in 27th Porto Cancer Meeting - Stemness & Metastasis: Advances in Research and Clinical Translation, 2021.
  23. Figueiredo J; Ferreira RM; Cravo J; Xu H; Maia AF; Melo S; Relvas JB; et al. "Integrin ß1 mediates the abnormal cell-matrix attachment and invasive behavior of E-cadherin mutant cells". Paper presented in EACR-AACR Basic and Translational Research Conference in partnership with ASPIC: Tumor Microevironment, Lisbon, Portugal, 2020.
  24. Pereira J; Melo S; Maia AF; de Klein A; Guilford P; Seruca R; Figueiredo J. "Cell-ECM adhesion features determine the clinical spectrum of E-cadherin germline mutations". Paper presented in EACR-AACR Basic and Translational Research Conference in partnership with ASPIC: Tumor Microevironment, Lisbon, Portugal, 2020.
  25. Carneiro P; Moreira AM; Figueiredo, Joana; Barros R; Oliveira P; Raquel Almeida; Oliveira, C; et al. "S100P modulates E-cadherin function in gastric cancer". Paper presented in EACR-AACR Basic and Translational Research Conference in partnership with ASPIC: Tumor Microevironment, Lisbon, Portugal, 2020.
  26. Melo S; Sanches JM; Figueiredo, Joana; Seruca R. "Unraveling the molecular and morphological features involved in basal extrusion of E-cadherin dysfunctional cells". Paper presented in EACR-AACR Basic and Translational Research Conference in partnership with ASPIC: Tumor Microevironment, Lisbon, Portugal, 2020.
  27. Figueiredo J; Ferreira RM; Cravo J; Maia AF; Melo S; Relvas JB; Seruca R. "Integrin ß1: a key player in the abnormal cell-matrix attachment and invasive behavior of E-cadherin mutant cells". Paper presented in 7th i3S Annual Meeting, Póvoa de Varzim, Portugal, 2018.
  28. Figueiredo J; Melo S; Gamet K; Godwin T; Seixas S; Sanches JM; Guilford P; Seruca R. "A novel regulation mechanism underlying loss of E-cadherin expression in Hereditary Diffuse Gastric Cancer families". Paper presented in 1st PhDay at i3S - From bench to stage, from desk to forum, i3S – Instituto de Investigação e Inovação em Saúde, Porto, 2018.
  29. Xu H; Figueiredo J; Paredes J; Seruca R; Smith ML; Stamenovic D. "Site-specific E-cadherin mutations affect gastric cancer cell tensional homeostasis". Paper presented in 2017 Biomedical Engineering Society (BMES) Annual Meeting, Phoenix, Arizona, US, 2017.
  30. Pena L; Perea J; Melo S; Mercadillo F; Figueiredo J; Sanches JM; Sánchez-Ruiz A; et al. "Identification and functional characterization of a CDH1 missense variant in three unrelated families with gastric cancer". Paper presented in InSiGHT 7th Biennial meeting, International Society for Gastrointestinal Hereditary Tumors Incorporated, Florence, Italy, 2017.
  31. Karam R; Schrader I; Lee K; Oliveira C; Roberts M; Nykamp K; Pesaran T; et al. "Optimization of the ACMG-AMP Criteria for CDH1 Variant Classification". Paper presented in Curating the Clinical Genome Meeting 2017 - ClinGen & Decipher meeting, Washington Marriott Georgetown, Washington, US, 2017.
  32. Pena L; Melo S; Perea J; Mercadillo F; Figueiredo J; Sanches JM; Sánchez-Ruiz A; et al. "CDH1 missense variant disrupts N-glycosylation and promotes gastric cancer". Paper presented in 50th Anniversary of the ESHG - The European Human Genetics Conference 2017, Copenhagen, Denmark, 2017.
  33. Figueiredo J; Ferreira RM; Cravo J; Maia AF; Melo S; Relvas JB; Seruca R. "Integrin ß1 is a key ECM receptor involved in the abnormal cell-matrix attachment and in invasive behaviour of E-cadherin mutants". Paper presented in 5th i3S Annual Meeting, Póvoa de Varzim, Portugal, 2016.
  34. Ferreira RM; Figueiredo J; Pinto-Ribeiro I; Carreto L; Castro P; Sgouras DN; Carneiro F; Seruca R; Figueiredo C. "Helicobacter pylori CagA-positive strains induces Laminin gamma-2 overexpression promoting cell invasion and survival". Paper presented in 5th i3S Annual Meeting, Póvoa de Varzim, Portugal, 2016.
  35. Melo S; Figueiredo J; Sanches JM; Seruca R. "Screening of cancer-causative E-cadherin missense mutations through the exploitation of morphological changes". Paper presented in 5th i3S Annual Meeting, Póvoa de Varzim, Portugal, 2016.
  36. Carneiro P; Moreira AM; Figueiredo J; Velho S; Vieira A; Oliveira P; Fernandes MS; et al. "S100P is a molecular determinant of E-cadherin function in gastric cancer". Paper presented in 5th i3S Annual Meeting, Póvoa de Varzim, Portugal, 2016.
  37. Melo S; Figueiredo J; Sanches JM; Seruca R. "Screening of cancer-causative E-cadherin missense mutations through the exploitation of morphological changes". Paper presented in 5th Symposium in Applied Bioimaging – Bioimaging 2016: Disease in Focus, Porto, Portugal, 2016.
  38. Figueiredo J; Ferreira RM; Cravo J; Maia AF; Melo S; Relvas JB; Seruca R. "Cancer cell-matrix adhesion properties depend on site-specific E-cadherin mutations". Paper presented in Gordon Research Conference - Signaling by Adhesion Receptors, Bates College, Lewiston - Maine, US, 2016.
  39. Carneiro P; Moreira AM; Figueiredo J; Velho S; Vieira A; Oliveira P; Fernandes MS; et al. "S100P is a molecular determinant of E-cadherin function in gastric cancer". Paper presented in Gordon Research Conference - Signaling by Adhesion Receptors, Bates College, Lewiston - Maine, US, 2016.
  40. Ribeiro AS; Nobre AR; Carvalho FA; Mestre T; Monteiro J; Fonseca M; Figueiredo J; et al. "Targeting P-cadherin/Src induced collective cell invasion and mechanotransduction signalling: dasatinib as a promising therapy to basal-like breast cancer". Paper presented in Gordon Research Conference - Signaling by Adhesion Receptors, Bates College, Lewiston - Maine, US, 2016.
  41. Mestre T; Figueiredo J; Seruca R; Sanches JM. "Cell-Cell adhesion dysfunction analysis from network topology". Paper presented in International Symposium on Biomedical Imaging (ISBI’16), Prague, Czech Republic, 2016.
  42. Carneiro P; Moreira AM; Figueiredo J; Velho S; Oliveira P; Fernandes MS; Ferro A; et al. "S100P is a molecular determinant of E-cadherin function in gastric cancer". Paper presented in 2nd ASPIC International Congress, Porto, Portugal, 2016.
  43. Ferreira RM; Figueiredo J; Pinto-Ribeiro I; Papadakos S; Sgouras DN; Castro P; Carneiro F; Seruca R; Figueiredo C. "Helicobacter pylori cagA-positive strains induce Laminin gamma-2 overexpression promoting cell invasion and survival". Paper presented in XXVIIIth International Workshop Helicobacter and Microbiota in Inflammation and Cancer, Nicosia, Cyprus, 2015.
  44. Figueiredo J; Caldeira J; Seruca R. "Understanding the E-cadherin-integrin-ECM crosstalk in gastric cancer". Paper presented in XXIVth FECTS meeting, 1st MBE (Matrix Biology Europe) conference, Rotterdam, The Netherlands, 2014.
  45. Carneiro P; Figueiredo J; Moreira AM; Oliveira P; Carneiro F; Seruca R. "Hereditary Diffuse Gastric Cancer – How to survive the loss of adhesion". Paper presented in 2013 CSHL Meeting on Cell Death, New York, US, 2013.
  46. Zhang L; Xiao A; Ruggeri J; Bacares R; Melo S; Figueiredo J; Simões-Correia J; Seruca R; Shah MA. "Missense Mutation of the Last Nucleotide of Exon 1, CDH1 c.48 G>C (Q16H), Contributes to Cancer Predisposition through Disruption of Normal Splicing and Generation of Missense Mutation". Paper presented in American Society of Human Genetics Annual Meeting, Boston, US, 2013.
  47. Esménio S; Figueiredo J; Seruca R; Sanches JM. "E-cadherin radial distribution characterization for mutation detection purposes". Paper presented in Pattern Recognition and Image Analysis - 6th Iberian Conference, IbPRIA 2013, Funchal, Madeira, Portugal, 2013.
  48. Esménio S; Figueiredo J; Seruca R; Sanches JM. "E-cadherin spatial characterization with radial distribution profile for mutation detection". Paper presented in RecPad 2012, 18th edition of the Portuguese Conference on Pattern Recognition, Coimbra, 2012.
  49. Carneiro P; Oliveira P; Figueiredo J; Oliveira C; Seruca R. "Unravelling the molecular determinants behind the tumour spectrum associated to TSG: CDH1 and HDGC as model". Paper presented in RecPad 2012, 18th edition of the Portuguese Conference on Pattern Recognition, Coimbra, 2012.
  50. Pinho SS; Carvalho S; Cabral J; Figueiredo J; Oliveira P; Gärtner F; Isaji T; et al. "N-acetylglucosaminyltransferases III and V regulate Ecadherin stability at the cell membrane. Implications in the Epithelial to Mesenchymal Transition". Paper presented in One Day Symposium with Carlos Caldas sponsored by EACR, Porto, 2012.
  51. Figueiredo J; Söderberg O; Simões-Correia J; Grannas K; Suriano G; Seruca R. "The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC". Paper presented in EACR Meeting, The Tumour Microenvironment, Dublin, Ireland, 2012.
  52. Carneiro P; Figueiredo J; Oliveira P; Oliveira C; Seruca R. "The Tumour Spectrum underlying Hereditary Diffuse Gastric Cancer". Paper presented in EACR Meeting, The Tumour Microenvironment, Dublin, Ireland, 2012.
  53. Simões-Correia J; Melo S; Figueiredo J; Caldeira J; Pereira P; Seruca R. "DNAJB4 differentially regulates WT and mutant E-cadherin in cancer". Paper presented in EACR-22, Barcelona, Spain, 2012.
  54. Pinho SS; Carvalho S; Cabral J; Figueiredo J; Oliveira P; Gärtner F; Isaji T; et al. "N-acetylglucosaminyltransferases III and V regulate E-cadherin stability at the cell membrane. Implications in the Epithelial to Mesenchymal Transition". Paper presented in 8th International Symposium on Glycosyltransferases, Glyco-T, Hannover, Germany, 2012.
  55. Vogelaar I; Figueiredo J; van Rooij I; Melo S; Carels C; van der Post C; Simões-Correia J; et al. "Identification of germline alterations in the cancer predisposing gene CDH1 in patients with cleft lip/palate". Paper presented in European Human Genetics Conference 2012, Nürnberg Convention Center Ost, Nürnberg, Germany, 2012.
  56. Figueiredo J; Söderberg O; Simões-Correia J; Grannas K; Suriano G; Seruca R. "The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC". Paper presented in 3th i3S Scientific Retreat, Póvoa do Varzim, Portugal, 2012.
  57. Pinho SS; Carvalho S; Cabral J; Figueiredo J; Oliveira P; Gärtner F; Isaji T; et al. "Glycosylation regulating E-cadherin stability: a mechanism with implications for cancer and for Epithelial to Mesenchymal Transition". Paper presented in 3th i3S Scientific Retreat, Póvoa do Varzim, Portugal, 2012.
  58. Carneiro P; Figueiredo J; Oliveira P; Pinto MT; Paredes J; Oliveira C; Carneiro F; Seruca R. "Unravelling the Tumour Spectrum in Hereditary Diffuse Gastric Cancer". Paper presented in 3th i3S Scientific Retreat, Póvoa do Varzim, Portugal, 2012.
  59. Pinho SS; Cabral J; Carvalho S; Figueiredo J; Gärtner F; Carneiro F; Taniguchi N; Seruca R; Reis CA. "N-Glycosylation: a novel molecular mechanism underlying E-cadherin dysfunction in gastric cancer". Paper presented in Digestive Disease Week 2012, San Diego, US, 2012.
  60. Figueiredo J; Simões-Correia J; Söderberg O; Suriano G; Seruca R. "ADP-Ribosylation factor 6 mediates E-cadherin recovery by Chemical Chaperones". Paper presented in Advanced Summer School - Interrogations at the Biointerface, Porto, Portugal, 2011.
  61. Figueiredo J; Simões-Correia J; Söderberg O; Suriano G; Seruca R. "ADP-Ribosylation factor 6 mediates E-cadherin recovery by Chemical Chaperones". Paper presented in 36th FEBS Congress - Biochemistry for tomorrow's medicine, Turin, Italy, 2011.
  62. Figueiredo J; Simões-Correia J; Söderberg O; Suriano G; Seruca R. "ADP-Ribosylation factor 6 mediates E-cadherin recovery by Chemical Chaperones". Paper presented in 2nd i3S Scientific Retreat, Póvoa do Varzim, Portugal, 2011.
  63. Marques P; Ferreira Z; Martins M; Figueiredo J; Correia J; Seixas S. "Contrasting features of the close homologues SERPINA2 and SERPINA1". Paper presented in 2nd I3S Scientific Retreat, Póvoa do Varzim, Portugal, 2011.
  64. Pinho SS; Reis CA; Paredes J; Magalhães AM; Ferreira AC; Figueiredo J; Xiaogang W; et al. "Role of N-acetylglucosaminyltransferase III and V in the Post-Translational Modifications of E-cadherin". Paper presented in Inaugural EuroGlycoscience Meeting “Glycosylation and Disease”, Dublin, Ireland, 2010.
  65. Marques P; Ferreira Z; Figueiredo J; Correia J; Rocha J; Seixas S. "Tales from a duplicated gene: the example of SERPINA2". Paper presented in Annual Meeting of the Society for Molecular Biology and Evolution, Lyon, France, 2010.
  66. Simões-Correia J; Fernandes JC; Figueiredo J; Lopes R; Serrano L; Casares F; Seruca R. "A translational approach to understand the post-transcriptional and post-translational regulation of E-cadherin". Paper presented in 1st I3S Scientific Retreat, Póvoa do Varzim, Portugal, 2010.
  67. Pinho SS; Reis CA; Paredes J; Magalhães AM; Ferreira AC; Figueiredo J; Xiaogang W; et al. "Role of N-acetylglucosaminyltransferase III and V in the Post-Translational Modifications of E-cadherin". Paper presented in 1st I3S Scientific Retreat, Póvoa do Varzim, Portugal, 2010.
  68. Ferreira Z; Marques P; Figueiredo J; Correia J; Rocha J; Seixas S. "From gene evolution to gene function: characterization of the newly identified Serpina2". Paper presented in American Society of Human Genetics – ASHG2009, Honolulu, USA, 2009.
  69. Caldeira J; Simões-Correia J; Figueiredo J; Vasconcelos F; Oliveira C; Suriano G; Seruca R; Casares F. "New E-cadherin Interactors: a Drosophila Model to Study CDH1 Germline Missense Mutations". Paper presented in Gordon Research Conference: Cell Contact & Adhesion – Cell-Cell Junction Functions, Polarity and Morphogenesis, Waterville Valley Resort, New Hampshire, USA, 2009.
  70. Simões-Correia J; Figueiredo J; van Hengel J; Seruca R; van Roy F; Suriano G. "Endoplasmic Reticulum Quality Control: a new mechanism of E-cadherin regulation and its implication in cancer". Paper presented in EMBO Meeting – The Biology of Molecular chaperones - Protein Homeostasis in Health and Disease, Dubrovnik, Croatia, 2009.
  71. Seca H; Santos L; Figueiredo J; Lima RT; Guimarães JE; Sambade C; Vasconcelos MH. "Targeting XIAP for chemosensitization purposes: different effect with different cytotoxic drugs". Paper presented in ASH Annual Meeting and Exposition-American Society of Hematology, San Francisco, US, 2008.
  72. Simões-correia, J.; Figueiredo, J.; van Hengel, J.; Seruca, R.; van Roy, F.; Suriano, G.. "E-cadherin missense mutations are regulated by the Endoplasmic Reticulum Quality Control". Paper presented in MedILS Summer Course: Hottest Topics in Protein Research, Mediterranean Institute for Life Sciences, Split, Croatia, 2008.
    10.1109/bibm.2013.6732584
  73. Seca H; Santos L; Figueiredo J; Lima RT; Guimarães JE; Sambade C; Vasconcelos MH. "Targeting XIAP as an approach to enhance the effects of chemotherapeutical drugs in K562 leukemia cells". Paper presented in SINAL 2008, Porto, Portugal, 2008.
  74. Simões-Correia J; Figueiredo J; van Hengel J; Seruca R; van Roy F; Suriano G. "Loss of Expression of E-cadherin Juxtamembrane Missense Mutations: a Task for the Proteasome". Paper presented in SINAL 2008, Porto, Portugal, 2008.
  75. Simões-Correia J; Figueiredo J; van Hengel J; Seruca R; van Roy F; Suriano G. "E-cadherin juxtamembrane missense mutations silencing: a Task for the Proteasome?". Paper presented in ONCOTRAIN Program: New battlefields in human cancer: Attacking in many fronts, CNIO, Madrid, Spain, 2008.
  76. Preto A; Figueiredo J; Velho S; Ribeiro AS; Soares P; Oliveira C; Seruca R. "BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAFV600E but not KRAS mutations". Paper presented in 11ª Reunião Anual da Sociedade de Genética Humana, Porto, Portugal, 2007.
Journal article
  1. Vieira, Diogo Fróis; Fernandes, Maria Sofia; Figueiredo, Joana; Melo, Soraia; Moreira, Ana Margarida; Machado, José Carlos; Seruca, Raquel; Sanches, João Miguel. "A novel computational approach to dissect the cytoskeletal architecture of cancer cells with invasive potential". Scientific Reports (IF 3.8, Q1 Multidisciplinary Sciences) 15 1 (2025): https://doi.org/10.1038/s41598-024-82538-w.
    Published • 10.1038/s41598-024-82538-w
  2. Lopes, Valéria; Figueiredo, Joana; Carneiro, Patrícia; Gouveia, Marcos; Travasso, Rui D. M.; Carvalho, João. "A 3D Computational Study on the Formation and Progression of Tumor Cells in Diffuse Gastric Cancer". Bulletin of Mathematical Biology (IF 2.0, Q2 Biology) 87 2 (2025): https://doi.org/10.1007/s11538-024-01405-x.
    10.1007/s11538-024-01405-x
  3. Santos, José Pedro; Figueiredo, Joana; Machado, José Carlos. "Gastric Cancer Genetics and Its Implications for Diagnosis, Prognosis, and Treatment of the Disease". The Korean Journal of Helicobacter and Upper Gastrointestinal Research 24 2 (2024): 103-112. https://doi.org/10.7704/kjhugr.2024.0018.
    10.7704/kjhugr.2024.0018
  4. Corso, Giovanni; Marino, Elena; Zanzottera, Cristina; Oliveira, Carla; Bernard, Loris; Macis, Debora; Figueiredo, Joana; et al. "CDH1 Genotype Exploration in Women With Hereditary Lobular Breast Cancer Phenotype". JAMA Network Open (IF 10.5, Q1 Medicine, General & Internal) 7 4 (2024): e247862. https://doi.org/10.1001/jamanetworkopen.2024.7862.
    10.1001/jamanetworkopen.2024.7862
  5. Pereira, Joana; Melo, Soraia; Ferreira, Rui M.; Carneiro, Patrícia; Yang, Vítor; Maia, André F.; Carvalho, João; et al. "E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner". Cell Communication and Signaling (IF 8.2, Q1 Cell Biology) 22 1 (2024): http://dx.doi.org/10.1186/s12964-024-01532-x.
    10.1186/s12964-024-01532-x
  6. Melo, Soraia; Guerrero, Pilar; Moreira Soares, Maurício; Bordin, José Rafael; Carneiro, Fátima; Carneiro, Patrícia; Dias, Maria Beatriz; et al. "The ECM and tissue architecture are major determinants of early invasion mediated by E-cadherin dysfunction". Communications Biology (IF 5.2, Q1 Biology) 6 1 (2023): https://doi.org/10.1038/s42003-023-05482-x.
    10.1038/s42003-023-05482-x
  7. João Sousa; Inês Castro; Figueiredo, Joana; Ferreira, Rui M.. "Gastric malignancies: microbes, biomarkers and molecular mechanisms.". Microbiota in Health and Disease 5 (2023): https://www.microbiotajournal.com/article/911.
    Published
  8. Ferreira, Rui M; Figueiredo, Joana; Pinto-Ribeiro, Ines; Gullo, Irene; Sgouras, Dionyssios N; Carreto, Laura; Castro, Patricia; et al. "Activation of Laminin gamma2 by Helicobacter pylori Promotes Invasion and Survival of Gastric Cancer Cells With E-Cadherin Defects". The Journal of Infectious Diseases (IF 6.4, Q1 Infectious Diseases) 226 12 (2022): 2226-2237. https://doi.org/10.1093/infdis/jiac397.
    10.1093/infdis/jiac397
  9. M. Mendes-Rocha; Figueiredo, Joana; Ferreira, Rui M.. "Gastric malignancies: bugs, pathways and molecular programs.". Microbiota in Health and Disease 4 3 (2022): https://www.microbiotajournal.com/article/729.
    Published
  10. Xu, Han; Bunde, Katie A.; Figueiredo, Joana; Seruca, Raquel; Smith, Michael L.; Stamenovic, Dimitrije. "Differential Impacts on Tensional Homeostasis of Gastric Cancer Cells Due to Distinct Domain Variants of E-Cadherin". Cancers (IF 5.2, Q2 Oncology) 14 11 (2022): 2690. https://doi.org/10.3390/cancers14112690.
    10.3390/cancers14112690
  11. Moreira, Ana M.; Ferreira, Rui M.; Carneiro, Patrícia; Figueiredo, Joana; Osório, Hugo; Barbosa, José; Preto, John; et al. "Proteomic Identification of a Gastric Tumor ECM Signature Associated With Cancer Progression". Frontiers in Molecular Biosciences (IF 5.0, Q2 Biochemistry & Molecular Biology) 9 (2022): https://doi.org/10.3389/fmolb.2022.818552.
    Open access • 10.3389/fmolb.2022.818552
  12. Figueiredo, Joana; Ferreira, Rui M.; Xu, Han; Gonçalves, Margarida; Barros-Carvalho, André; Cravo, Janine; Maia, André F.; et al. "Integrin ß1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells". Gastric Cancer (IF 7.4 , Q1 Oncology) 25 1 (2021): 124-137. https://doi.org/10.1007/s10120-021-01239-9.
    10.1007/s10120-021-01239-9
  13. Figueiredo, Joana; Mercadillo, Fátima; Melo, Soraia; Barroso, Alicia; Gonçalves, Margarida; Díaz-Tasende, José; Carneiro, Patrícia; et al. "Germline CDH1 G212E Missense Variant: Combining Clinical, In Vitro and In Vivo Strategies to Unravel Disease Burden". Cancers (IF 6.575, Q1 Oncology) 13 17 (2021): 4359. https://doi.org/10.3390/cancers13174359.
    10.3390/cancers13174359
  14. Corso, Giovanni; Corso, Federica; Bellerba, Federica; Carneiro, Patrícia; Seixas, Susana; Cioffi, Antonio; La Vecchia, Carlo; et al. "Geographical Distribution of E-cadherin Germline Mutations in the Context of Diffuse Gastric Cancer: A Systematic Review". Cancers (IF 6.575 , Q1 Oncology) 13 6 (2021): 1269. https://doi.org/10.3390/cancers13061269.
    10.3390/cancers13061269
  15. Blair, Vanessa R; McLeod, Maybelle; Carneiro, Fátima; Coit, Daniel G; D'Addario, Johanna L; van Dieren, Jolanda M; Harris, Kirsty L; et al. "Hereditary diffuse gastric cancer: updated clinical practice guidelines". The Lancet Oncology (IF 41.316, Q1 Oncology) 21 8 (2020): e386-e397. https://doi.org/10.1016/s1470-2045(20)30219-9.
    10.1016/s1470-2045(20)30219-9
  16. Corso, Giovanni; Montagna, Giacomo; Figueiredo, Joana; La Vecchia, Carlo; Fumagalli Romario, Uberto; Fernandes, Maria Sofia; Seixas, Susana; et al. "Hereditary Gastric and Breast Cancer Syndromes Related to CDH1 Germline Mutation: A Multidisciplinary Clinical Review". Cancers (IF 6.639, Q1 Oncology) 12 6 (2020): 1598. https://doi.org/10.3390/cancers12061598.
    10.3390/cancers12061598
  17. Corso, Giovanni; Figueiredo, Joana; De Angelis, Simone Pietro; Corso, Federica; Girardi, Antonia; Pereira, Joana; Seruca, Raquel; et al. "E-cadherin deregulation in breast cancer". Journal of Cellular and Molecular Medicine (IF 5.310, Q2 Medicine, Research & Experimental) 24 11 (2020): 5930-5936. https://doi.org/10.1111/jcmm.15140.
    10.1111/jcmm.15140
  18. Moreira, Ana Margarida; Pereira, Joana; Melo, Soraia; Fernandes, Maria Sofia; Carneiro, Patrícia; Seruca, Raquel; Figueiredo, Joana. "The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression". Cells (IF 6.600, Q2 Cell Biology) 9 2 (2020): 394. https://doi.org/10.3390/cells9020394.
    10.3390/cells9020394
  19. Carneiro, Patrícia; Moreira, Ana Margarida; Figueiredo, Joana; Barros, Rita; Oliveira, Patrícia; Fernandes, Maria Sofia; Ferro, Anabela; et al. "S100P is a molecular determinant of E-cadherin function in gastric cancer". Cell Communication and Signaling (IF 4.344, Q2 Cell Biology) 17 1 (2019): https://doi.org/10.1186/s12964-019-0465-9.
    10.1186/s12964-019-0465-9
  20. Figueiredo, Joana; Melo, Soraia; Carneiro, Patrícia; Moreira, Ana Margarida; Fernandes, Maria Sofia; Ribeiro, Ana Sofia; Guilford, Parry; Paredes, Joana; Seruca, Raquel. "Clinical spectrum and pleiotropic nature of CDH1 germline mutations". Journal of Medical Genetics (IF 4.943, Q1 Genetics and Heredity) 56 4 (2019): 199-208. https://doi.org/10.1136/jmedgenet-2018-105807.
    10.1136/jmedgenet-2018-105807
  21. Lee, Kristy; Krempely, Kate; Roberts, Maegan E.; Anderson, Michael J.; Carneiro, Fatima; Chao, Elizabeth; Dixon, Katherine; et al. "Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline CDH1 sequence variants". Human Mutation (IF 4.453, Q1 Genetics and Heredity) 39 11 (2018): 1553-1568. https://doi.org/10.1002/humu.23650.
    10.1002/humu.23650
  22. Figueiredo, Joana; Melo, Soraia; Gamet, Kimberley; Godwin, Tanis; Seixas, Susana; Sanches, João M.; Guilford, Parry; Seruca, Raquel. "E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer". Molecular Cancer (IF 10.679, Q1 Oncology) 17 1 (2018): https://doi.org/10.1186/s12943-018-0859-0.
    10.1186/s12943-018-0859-0
  23. Figueiredo, Joana; Rodrigues, Isabel; Ribeiro, João; Fernandes, Maria Sofia; Melo, Soraia; Sousa, Bárbara; Paredes, Joana; Seruca, Raquel; Sanches, João M.. "Geometric compensation applied to image analysis of cell populations with morphological variability: a new role for a classical concept". Scientific Reports (IF 4.011, Q1 Multidisciplinary Sciences) 8 1 (2018): https://doi.org/10.1038/s41598-018-28570-z.
    10.1038/s41598-018-28570-z
  24. Corso, Giovanni; Figueiredo, Joana; La Vecchia, Carlo; Veronesi, Paolo; Pravettoni, Gabriella; Macis, Debora; Karam, Rachid; et al. "Hereditary lobular breast cancer with an emphasis on E-cadherin genetic defect". Journal of Medical Genetics (IF 5.899, Q1 Genetics and Heredity) 55 7 (2018): 431-441. https://doi.org/10.1136/jmedgenet-2018-105337.
    10.1136/jmedgenet-2018-105337
  25. Pena-Couso, Laura; Perea, José; Melo, Soraia; Mercadillo, Fátima; Figueiredo, Joana; Sanches, João Miguel; Sánchez-Ruiz, Antonio; et al. "Clinical and functional characterization of the CDH1 germline variant c.1679CtoG in three unrelated families with hereditary diffuse gastric cancer". European Journal of Human Genetics (IF 3.650, Q2 Genetics and Heredity) 26 9 (2018): 1348-1353. https://doi.org/10.1038/s41431-018-0173-8.
    10.1038/s41431-018-0173-8
  26. Zollinger, Alicia J.; Xu, Han; Figueiredo, Joana; Paredes, Joana; Seruca, Raquel; Stamenovic, Dimitrije; Smith, Michael L.. "Dependence of Tensional Homeostasis on Cell Type and on Cell–Cell Interactions". Cellular and Molecular Bioengineering (IF 2.477, Q2 Engineering, Biomedical) 11 3 (2018): 175-184. https://doi.org/10.1007/s12195-018-0527-x.
    10.1007/s12195-018-0527-x
  27. Melo, Soraia; Figueiredo, Joana; Fernandes, Maria; Gonçalves, Margarida; Morais-de-Sá, Eurico; Sanches, João; Seruca, Raquel. "Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer". International Journal of Molecular Sciences (IF 3.687, Q2 Biochemistry and Molecular Biology) 18 12 (2017): 2687. https://doi.org/10.3390/ijms18122687.
    10.3390/ijms18122687
  28. Mestre, Tânia; Figueiredo, Joana; Ribeiro, Ana Sofia; Paredes, Joana; Seruca, Raquel; Sanches, João Miguel. "Quantification of topological features in cell meshes to explore E-cadherin dysfunction". Scientific Reports (IF 4.259, Q1 Multidisciplinary Sciences) 6 1 (2016): https://doi.org/10.1038/srep25101.
    10.1038/srep25101
  29. Ribeiro, A. S.; Carvalho, F. A.; Figueiredo, J.; Carvalho, R.; Mestre, T.; Monteiro, J.; Guedes, A. F.; et al. "Atomic force microscopy and graph analysis to study the P-cadherin/SFK mechanotransduction signalling in breast cancer cells". Nanoscale (IF 7.367, Q1 Nanoscience and Nanotechnology) 8 46 (2016): 19390-19401. https://doi.org/10.1039/c6nr04465d.
    10.1039/c6nr04465d
  30. Caldeira, Joana; Figueiredo, Joana; Brás-Pereira, Catarina; Carneiro, Patrícia; Moreira, Ana M.; Pinto, Marta T.; Relvas, João B.; et al. "E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade". Human Molecular Genetics (IF 5.985, Q1 Biochemistry and Molecular Biology) 24 20 (2015): 5891-5900. https://doi.org/10.1093/hmg/ddv312.
    10.1093/hmg/ddv312
  31. Brito, Luciano Abreu; Yamamoto, Guilherme Lopes; Melo, Soraia; Malcher, Carolina; Ferreira, Simone Gomes; Figueiredo, Joana; Alvizi, Lucas; et al. "Rare Variants in the Epithelial Cadherin Gene Underlying the Genetic Etiology of Nonsyndromic Cleft Lip with or without Cleft Palate". Human Mutation (IF 5.089, Q1 Genetics and Heredity) 36 11 (2015): 1029-1033. https://doi.org/10.1002/humu.22827.
    10.1002/humu.22827
  32. Carvalho, S; Catarino, T A; Dias, A M; Kato, M; Almeida, A; Hessling, B; Figueiredo, J; et al. "Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer". Oncogene (IF 7.932, Q1 Oncology) 35 13 (2015): 1619-1631. https://doi.org/10.1038/onc.2015.225.
    10.1038/onc.2015.225
  33. van der Post, Rachel S; Vogelaar, Ingrid P; Carneiro, Fátima; Guilford, Parry; Huntsman, David; Hoogerbrugge, Nicoline; Caldas, Carlos; et al. "Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers". Journal of Medical Genetics (IF 5.650, Q1 Genetics and Heredity) 52 6 (2015): 361-374. https://doi.org/10.1136/jmedgenet-2015-103094.
    10.1136/jmedgenet-2015-103094
  34. Oliveira, Carla; Pinheiro, Hugo; Figueiredo, Joana; Seruca, Raquel; Carneiro, Fátima. "Familial gastric cancer: genetic susceptibility, pathology, and implications for management". The Lancet Oncology (IF 26.509, Q1 Oncology) 16 2 (2015): e60-e70. https://doi.org/10.1016/s1470-2045(14)71016-2.
    10.1016/s1470-2045(14)71016-2
  35. Zhang, Liying; Xiao, Alexander; Ruggeri, Jeanine; Bacares, Ruben; Somar, Joshua; Melo, Soraia; Figueiredo, Joana; et al. "The germline CDH1 c.48 G to C substitution contributes to cancer predisposition through generation of a pro-invasive mutation". Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis (IF 3.680, Q1 Biotechnology and applied microbiology) 770 (2014): 106-111. https://doi.org/10.1016/j.mrfmmm.2014.10.001.
    10.1016/j.mrfmmm.2014.10.001
  36. Sanches, João Miguel; Figueiredo, Joana; Fonseca, Martina; Durães, Cecília; Melo, Soraia; Esménio, Sofia; Seruca, Raquel. "Quantification of mutant E-cadherin using bioimaging analysis of in situ fluorescence microscopy. A new approach to CDH1 missense variants". European Journal of Human Genetics (IF 4.580, Q1 Biochemistry and Molecular Biology) 23 8 (2014): 1072-1079. https://doi.org/10.1038/ejhg.2014.240.
    10.1038/ejhg.2014.240
  37. Corso, Giovanni; Figueiredo, Joana; Biffi, Roberto; Trentin, Chiara; Bonanni, Bernardo; Feroce, Irene; Serrano, Davide; et al. "E-cadherin germline mutation carriers: clinical management and genetic implications". Cancer and Metastasis Reviews (IF 7.234, Q1 Oncology) 33 4 (2014): 1081-1094. https://doi.org/10.1007/s10555-014-9528-y.
    10.1007/s10555-014-9528-y
  38. Simões-Correia, Joana; Silva, Diana I.; Melo, Soraia; Figueiredo, Joana; Caldeira, Joana; Pinto, Marta T.; Girão, Henrique; Pereira, Paulo; Seruca, Raquel. "DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo". Human Molecular Genetics (IF 6.393, Q1 Biochemistry and Molecular Biology) 23 8 (2013): 2094-2105. https://doi.org/10.1093/hmg/ddt602.
    10.1093/hmg/ddt602
  39. Carneiro, Patrícia; Figueiredo, Joana; Bordeira-Carriço, Renata; Fernandes, Maria Sofia; Carvalho, Joana; Oliveira, Carla; Seruca, Raquel. "Therapeutic targets associated to E-cadherin dysfunction in gastric cancer". Expert Opinion on Therapeutic Targets (IF 4.901, Q1 Pharmacology and Pharmacy) 17 10 (2013): 1187-1201. https://doi.org/10.1517/14728222.2013.827174.
    10.1517/14728222.2013.827174
  40. Marques, Patrícia Isabel; Ferreira, Zélia; Martins, Manuella; Figueiredo, Joana; Silva, Diana Isabel; Castro, Patrícia; Morales-Hojas, Ramiro; Simões-Correia, Joana; Seixas, Susana. "SERPINA2 Is a Novel Gene with a Divergent Function from SERPINA1". PLoS ONE (IF 3.534, Q1 Multidisciplinary Sciences) 8 6 (2013): e66889. https://doi.org/10.1371/journal.pone.0066889.
    10.1371/journal.pone.0066889
  41. Pinho, Salomé S.; Figueiredo, Joana; Cabral, Joana; Carvalho, Sandra; Dourado, Joana; Magalhães, Ana; Gärtner, Fátima; et al. "E-cadherin and adherens-junctions stability in gastric carcinoma: Functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V". Biochimica et Biophysica Acta (BBA) - General Subjects (IF 3.829, Q2 Biochemistry and Molecular Biology) 1830 3 (2013): 2690-2700. https://doi.org/10.1016/j.bbagen.2012.10.021.
    10.1016/j.bbagen.2012.10.021
  42. Paredes, Joana; Figueiredo, Joana; Albergaria, André; Oliveira, Patrícia; Carvalho, Joana; Ribeiro, Ana Sofia; Caldeira, Joana; et al. "Epithelial E- and P-cadherins: Role and clinical significance in cancer". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (IF 9.033, Q1 Biochemistry and Molecular Biology) 1826 2 (2012): 297-311. https://doi.org/10.1016/j.bbcan.2012.05.002.
    10.1016/j.bbcan.2012.05.002
  43. Vogelaar, I. P.; Figueiredo, J.; van Rooij, I. A. L. M.; Simoes-Correia, J.; van der Post, R. S.; Melo, S.; Seruca, R.; et al. "Identification of germline mutations in the cancer predisposing gene CDH1 in patients with orofacial clefts". Human Molecular Genetics (IF 6.677, Q1 Genetics and Heredity) 22 5 (2012): 919-926. https://doi.org/10.1093/hmg/dds497.
    10.1093/hmg/dds497
  44. Figueiredo, Joana; Söderberg, Ola; Simões-Correia, Joana; Grannas, Karin; Suriano, Gianpaolo; Seruca, Raquel. "The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC". European Journal of Human Genetics (IF 4.225, Q1 Genetics and Heredity) 21 3 (2012): 301-309. https://doi.org/10.1038/ejhg.2012.159.
    10.1038/ejhg.2012.159
  45. Carneiro, Patrícia; Fernandes, Maria Sofia; Figueiredo, Joana; Caldeira, Joana; Carvalho, Joana; Pinheiro, Hugo; Leite, Marina; et al. "E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions". FEBS Letters (IF 3.582, Q2 Biochemistry and Molecular Biology) 586 18 (2012): 2981-2989. https://doi.org/10.1016/j.febslet.2012.07.045.
    10.1016/j.febslet.2012.07.045
  46. Garziera, Marica; De Re, Valli; Geremia, Silvano; Seruca, Raquel; Figueiredo, Joana; Melo, Soraia; Simões-Correia, Joana; et al. "A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy". Clinical and Experimental Medicine (IF 2.824, Q2 Medicine, Research and Experimental) 13 2 (2012): 149-157. https://doi.org/10.1007/s10238-012-0184-7.
    10.1007/s10238-012-0184-7
  47. Simões-Correia, Joana; Figueiredo, Joana; Lopes, Rui; Stricher, François; Oliveira, Carla; Serrano, Luis; Seruca, Raquel. "E-cadherin Destabilization Accounts for the Pathogenicity of Missense Mutations in Hereditary Diffuse Gastric Cancer". PLoS ONE (IF 3.730, Q1 Multidisciplinary Sciences) 7 3 (2012): e33783. https://doi.org/10.1371/journal.pone.0033783.
    10.1371/journal.pone.0033783
  48. Simoes-Correia, J.; Melo, S.; Figueiredo, J.; Caldeira, J.; Pereira, P.; Seruca, R.. "DNAJB4 Differentially Regulates WT and Mutant E-cadherin in Cancer". European Journal of Cancer 48 (2012): S78-S78. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000313036500294&KeyUID=WOS:000313036500294.
  49. Kluijt, Irma; Siemerink, Ester J.M.; Ausems, Margreet G.E.M.; van Os, Theo A.M.; de Jong, Daphne; Simões-Correia, Joana; van Krieken, J. Han; et al. "CDH1-related hereditary diffuse gastric cancer syndrome: Clinical variations and implications for counseling". International Journal of Cancer (IF 6.198, Q1 Oncology) 131 2 (2011): 367-376. https://doi.org/10.1002/ijc.26398.
    10.1002/ijc.26398
  50. Figueiredo, Joana; Simões-Correia, Joana; Söderberg, Ola; Suriano, Gianpaolo; Seruca, Raquel. "ADP-Ribosylation Factor 6 Mediates E-Cadherin Recovery by Chemical Chaperones". PLoS ONE (IF 4.092, Q1 Multidisciplinary Sciences) 6 8 (2011): e23188. https://doi.org/10.1371/journal.pone.0023188.
    10.1371/journal.pone.0023188
  51. Preto, Ana; Gonçalves, Joana; Rebocho, Ana P; Figueiredo, Joana; Meireles, Ana M; Rocha, Ana S; Vasconcelos, Helena M; et al. "Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations". BMC Cancer (IF 2.736, Q2 Oncology) 9 1 (2009): https://doi.org/10.1186/1471-2407-9-387.
    10.1186/1471-2407-9-387
  52. Mateus, Ana Rita; Simões-Correia, Joana; Figueiredo, Joana; Heindl, Stefan; Alves, Catarina Castro; Suriano, Gianpaolo; Luber, Birgit; Seruca, Raquel. "E-cadherin mutations and cell motility: A genotype–phenotype correlation". Experimental Cell Research (IF 3.589, Q2 Oncology) 315 8 (2009): 1393-1402. https://doi.org/10.1016/j.yexcr.2009.02.020.
    10.1016/j.yexcr.2009.02.020
  53. Pinho, S. S.; Reis, C. A.; Paredes, J.; Magalhaes, A. M.; Ferreira, A. C.; Figueiredo, J.; Xiaogang, W.; et al. "The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin". Human Molecular Genetics (IF 7.386, Q1 Biochemistry and Molecular Biology) 18 14 (2009): 2599-2608. https://doi.org/10.1093/hmg/ddp194.
    10.1093/hmg/ddp194
  54. Bajpai, Saumendra; Correia, Joana; Feng, Yunfeng; Figueiredo, Joana; Sun, Sean X.; Longmore, Gregory D.; Suriano, Gianpaolo; Wirtz, Denis. "a-Catenin mediates initial E-cadherin-dependent cell–cell recognition and subsequent bond strengthening". Proceedings of the National Academy of Sciences (IF 9.380, Q1 Multidisciplinary sciences) 105 47 (2008): 18331-18336. https://doi.org/10.1073/pnas.0806783105.
    10.1073/pnas.0806783105
  55. Simoes-Correia, J.; Figueiredo, J.; Oliveira, C.; van Hengel, J.; Seruca, R.; van Roy, F.; Suriano, G.. "Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer". Human Molecular Genetics (IF 7.249, Q1 Biochemistry and Molecular Biology) 17 22 (2008): 3566-3576. https://doi.org/10.1093/hmg/ddn249.
    10.1093/hmg/ddn249
  56. Preto, A; Figueiredo, J; Velho, S; Ribeiro, AS; Soares, P; Oliveira, C; Seruca, R. "BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF V600E but not KRAS mutations". The Journal of Pathology (IF 5.121, Q1 Oncology) 214 3 (2008): 320-327. https://doi.org/10.1002/path.2295.
    10.1002/path.2295
  57. Preto, Ana; Moutinho, Cátia; Velho, Sérgia; Oliveira, Carla; Rebocho, Ana Paula; Figueiredo, Joana; Soares, Paula; Lopes, José Manuel; Seruca, Raquel. "A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation". Virchows Archiv (IF 2.029, Q2 Pathology) 450 6 (2007): 619-626. https://doi.org/10.1007/s00428-007-0420-9.
    10.1007/s00428-007-0420-9
Thesis / Dissertation
  1. Figueiredo, Joana. "The role of E-cadherin trafficking regulation in epithelial cancer progression". PhD, Universidade do Porto Faculdade de Medicina, 2012.
  2. "Effects of XIAP downregultion by RNAi in the response of K562 leukemia cells to chemotherapeutical drugs". Degree, Universidade do Minho, 2005.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/09/19 E-cadherin dysfunction modulates nuclear architecture in gastric cancer cells 19th YES (Young European Scientist) Meeting, Medical Faculty of University of Porto
Medical Faculty of University of Porto-FMUP (Porto, Portugal)
2024/09/13 Gastric cancer invasion: physical and biochemical nuclear readouts elicited by E-cadherin loss 37th Workshop of the European Helicobacter and Microbiota Study Group
EHMSG-European Helicobacter and Microbiota Study Group (Porto, Portugal)
2024/06/14 Current status on in vitro, in vivo and in silico models of HDGC 5th International Gastric Cancer Linkage Consortium (IGCLC) Meeting
International Gastric Cancer Linkage Consortium-IGCLC (Porto, Portugal)
2023/11/16 Cell extrusion signatures: a crosstalk between E-cadherin and Filamin A 10th i3S Annual Meeting
i3S-Instituto de Investigação e Inovação em Saúde (Póvoa do Varzim, Portugal)
2023/10/25 Computational approach for cytoskeletal organization characterization SPAOM2023, Spanish-Portuguese Meeting for Advanced Optical Microscopy
Portuguese and Spanish Advanced Optical Microscopy (Faro, Portugal)
2023/10/03 Motile performance and expression signatures underlying CDH1 clinical spectrum 6th PhDay | Brilliant PhDs, brighter future: Shaping Science together
i3S-Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2021/10/03 Abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells 21st International Meeting on Adhesion Biology
Max Planck Institute / ETH Zurich / University of Porto (Marvão, Portugal)
2019/12/13 E-cadherin mutations and remodeling of cell-extracellular matrix (ECM) interactions Hereditary Breast and Gastric Cancers: Prevention, Genetics, and Care
European Institute of Oncology (IEO Education) (Milan, Italy)
2019/03/17 Current and future strategies to evaluate the functional impact of E-cadherin missense variants 2019 IGCLC Hereditary Diffuse Gastric Cancer Consensus Clinical Guidelines Meeting
International Gastric Cancer Linkage Consortium-IGCLC (Wanaka, New Zealand)
2018/05/10 A novel regulation mechanism underlying loss of E-cadherin expression in Hereditary Diffuse Gastric Cancer families 3rd ASPIC International Congress
Gulbenkian Foundation (Lisbon, Portugal)
2017/07/25 Effects of mutated E-cadherin on human gastric cancer cell tensional homeostasis 54th Annual Technical Meeting of the Society of Engineering Science – SES 2017
Northeastern University (Boston, United States)
2017/06/30 E-cadherin missense mutations as model to identify therapeutic targets in HDGC Knowns and unknowns in Gastric Cancer and other tumours of the digestive system
(Porto, Portugal)
2016/11 E-cadherin, much more than an adhesion molecule. Cancer-causing CDH1 missense mutations as a model system Invited Scientist Seminar
(Sevilha, Spain)
2015/11/05 Shapes and colour to determine epithelial organization and cell polarity 4th International Symposium in Applied Bioimaging - The pre-clinical challenge in 3D
(Porto, Portugal)
2014/03/19 Unclassified CDH1 sequence variants in functional terms? International Gastric Cancer Linkage Consortium meeting
International Gastric Cancer Linkage Consortium-IGCLC (Netherlands)
2013/10/03 Quantitation of E-cadherin protein expression as a means to predict its function International Symposium in Applied Bioimaging from Molecule to Man
(Porto, Portugal)
2013/09/18 Unclassified sequence variants in functional terms? E-cadherin gene (CDH1) as model 3rd Global Cancer Genomics Consortium Symposium
(Lisboa, Portugal)
2012/10/29 E-cadherin disfunction in gastric cancer. Cellular consequences and clinical applications One Day Symposium with Carlos Caldas sponsored by EACR
The European Association for Cancer Research-EACR (Porto, Portugal)
2012/09/20 Characterization of E-cadherin Distribution from Fluorescence Images Bioimaging 2012 - Bridging Development and Application
(Porto, Portugal)
2012/09/04 E-cadherin disfunction in gastric cancer: cellular consequences and clinical applications 22nd IUBMB - 37th FEBS
Federation of European Biochemical Societies-FEBS (Sevilha, Spain)
2012/06 N-acetylglucosaminyltransferases III and V regulate E-cadherin stability at the cell membrane. Implications in the Epithelial to Mesenchymal Transition 8th International Symposium on Glycosyltransferases, Glyco-T
(Hannover, Germany)
2012/05 Glycosylation regulating E-cadherin stability: a mechanism with implications for cancer and for Epithelial to Mesenchymal Transition 3th i3S Scientific Retreat
i3S-Instituto de Inovação em Saúde (Porto, Portugal)
2011/11/23 My E-(cadherin) and the Others IX Encontro Anual da Engenharia Biomédica
Faculdade Medicina da Universidade de Lisboa and Instituto Superior Técnico da Universidade Técnica de Lisboa (Porto, Portugal)
2011/06/01 Gastric Cancer, two molecular identities - two distinct therapies XXXVI Jornadas Portuguesas de Genética
(Porto, Portugal)
2011/05/27 Gastric cancer- Molecular markers as tools to improve diagnosis, prognostic and therapeutic selection Update of Pathological Anathomy and Clinical Relapse
(Sorrento, Italy)
2010/12/15 Molecular basis of gastric cancer XVII Congresso Nacional de Bioquímica
(Porto, Portugal)
2010/09/26 E-cadherin mediated cellular effects and molecular partners. Gastric cancer as an invasive model 16th International Charles Heidelberger Symposium on Cancer Research
(Coimbra, Portugal)
2008/12 ER Quality Control: a new mechanism of E-cadherin regulation and its implication in cancer 12th Annual GABBA Scientific Meeting
IPATIMUP (Porto, Portugal)
2008/11 ER Quality Control: a new mechanism of E-cadherin regulation and its implication in cancer 1º Encontro Nacional de Química Terapêutica
University of Porto (Porto, Portugal)
2008/07 E-cadherin expression is regulated by the ER Quality Control pathway MedILS Summer Course in Hottest Topics in Protein Research
Mediterranean Institute for Life Sciences (Split, Croatia)
2008/03 Loss of Expression of E-Cadherin Juxtamembrane Missense Mutations: a Task for the Proteasome? Young Scientist Seminar
Center for Neurosciences and Cell Biology, University of Coimbra (Coimbra, Portugal)
2007/04 Sensitivity of Thyroid cancer cells to BAY 43-9006 is distinct from BRAF specific inhibition. Biological and therapeutic implications First Iberic Meeting on Medical Chemistry-Anticancer Agents
(Régua, Portugal)
2007 MAP kinase signalling pathway in gastrointestinal cancer First Iberic Meeting on Medical Chemistry-Anticancer Agents
(Régua, Portugal)
2006/12 Downregulation of XIAP expression with siRNAs in K562 cells: effects on cellular sensitivity to doxorubicin Congresso Nacional de Bioquímica
University of Aveiro (Aveiro, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/11 - Current Artificial intelligence to unveil cytoskeletal-nuclear dynamics triggering cancer invasion
Supervisor of Diogo João Fróis Vieira
 Biomedical Engineering (PhD)
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2023/11 - Current Biomechanical clues from the nucleus: deciphering the code for invasive gastric cancer
Supervisor of Ana Luísa Queirós Carvalho
Biomedicine (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2023/09 - Current Targeting nucleus-E-cadherin dynamics in gastric cancer cells
Supervisor of José Pedro Oliveira Santos
 Molecular Medicine and Oncology (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2020/01 - 2024/11 Addressing migration dynamics of E-cadherin dysfunctional cells during epithelial closure: a new approach to predict the risk for orofacial clefting disorders
Supervisor of Joana Sousa Pereira
 Biomedicine (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/03 - 2024/01 Identifying nuclear biomarkers for predictive prognosis of hereditary diffuse gastric cancer
Supervisor of Soraia Miliza da Cruz Santiago Mamede de Melo
Postdoctoral researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/04 - 2023/10 Nuclear cues in invasive cancer: overriding E-cadherin dysfunction
Supervisor of Ana Luísa Queirós Carvalho
Research fellowship - Master (Other)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/06 - 2022/06 Nuclear invasive signatures in E-cadherin dysfunctional cells
Supervisor of Ana Catarina da Rocha Nunes
Biology (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2019/01 - 2021/06 Oral facial congenital malformations and gastric cancer risk: a matter of E-cadherin-mediated cell-extracellular matrix adhesion
Supervisor of Patrícia Alexandra Barreiras Carneiro
 Postdoctoral researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/10 - 2021/01 Diagnose cancer-causative E-cadherin missense mutations through molecular and morphological changes involved in cell extrusion
Co-supervisor of Soraia Miliza da Cruz Santiago Mamede de Melo
 Biomedicine (PhD)
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2018/04 - 2019/12 Mechanisms underlying the sensing of E-cadherin dysfunctional cells by normal epithelia
Supervisor of Joana Sousa Pereira
 Research fellowship - Master (Master)
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2013/11 - 2015/10 The role of mutant E-cadherin-integrin-ECM crosstalk in gastric cancer
Supervisor of Janine Anselmo Cravo
 Research fellowship - Master (Master)
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2010/07 - 2015/09 The role of protein quality control in the regulation of E-cadherin and its relevance in cancer
Supervisor of Soraia Miliza da Cruz Santiago Mamede de Melo
 Research fellowship - Master (Master)
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2011/11 - 2012/04 Cancer stem cells: a new player in gastric cancer development
Supervisor of Arian van der Maarel
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Hogeschool Van Hall Larenstein, Netherlands

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2025/05/14 - 2025/05/16 31st PORTO CANCER MEETING, Breaking boundaries: adhesion regulation in cancer | i3S - Institute for Research and Innovation in Health, Porto (2025/05/14 - 2025/05/16)
Congress (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024/09/12 - 2024/09/14 37th WORKSHOP OF THE EUROPEAN HELICOBACTER AND MICROBIOTA STUDY GROUP | Fundação Eng. António de Almeida, Porto (2024/09/12 - 2024/09/14)
Congress (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024/06/13 - 2024/06/15 5th INTERNATIONAL GASTRIC CANCER LINKAGE CONSORTIUM (IGCLC) MEETING | Vilar Oporto Hotel, Porto (2024/06/13 - 2024/06/15)
Congress (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2025/02/07 - 2025/02/07 Presentation in a matchmaking event to highlight the scientific work conducted in our lab and promote available academic internships. The main objective of this event was to disseminate our research line and inspire scientific curiosity among Master students, who are looking to integrate a research group for the development of their thesis.
Exhibition
 IV MSc Open Day
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024/10/31 - 2024/10/31 Oral presentation entitled “From my passion for biology to the fight against cancer: my academic and scientific journey” delivered in the framework of the i3S Educational Program. This initiative aims to promote education, disseminate knowledge, and inspire scientific curiosity among high school students and teachers.
Seminar
 i3S Educational Program
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/01/07 - 2022/01/27 Interview in the context of the Program in Science and Technology developed at the High School of Castelo da Maia - "Perspectives from a cancer researcher". 11th Grade, 2022/2023. Science and Technology Program
Escola Secundária do Castelo da Maia, Portugal
2015/05/05 - 2015/05/12 Exhibition for the general public to increase people's literacy regarding health and cancer problems, thus stimulating prevention and early diagnosis of the disease.
Exhibition
 Os Passos da Ciência nos Paços do Concelho
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2014/11/14 - 2014/11/15 Dissemination to the general public of information concerning gastric cancer aetiology, prevention and early detection.
Exhibition
 IPATIMUP Opening Day
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2005/04 - 2007/04 Dissemination of scientific research within an exhibition promoted by University of Porto targeting high school students. This exhibition aims to provide students information regarding the institution's educational offer to aid future vocational decisions. The University of Porto is a reference institution in Portugal, currently among the 150 best European universities according to important international rankings of Higher Education.
Exhibition
 Mostra da Universidade do Porto - Editions 2005 / 2006 / 2007
Universidade do Porto, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/12/13 Establishment of tissue microarrays for the characterisation of tumour tissue
(Thesis) Main arguer
 Mariana Gomes Correia (Master)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2024/07/15 Evaluation of the impact of microbiome-derived metabolites in gastric cancer - Probationary year of Master
(Thesis) Main arguer
 João Miguel Gomes de Sousa (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2023/07/20 Uncovering the role of microbiome-derived metabolites in gastric cancer - Probationary year of Master
(Thesis) Main arguer
 Inês Nóbrega e Costa Pimentel De Castro (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2023/05/29 The role of the microbiota in esophageal cancer
(Thesis) Main arguer
 Clara Isabel dos Santos Moreira (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2020/12/10 The role of ubiquitin specific proteases in cancer development through interaction with critical cellular processes
(Thesis) Main arguer
 Lucas Lopes Cruz (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2019/06/19 Effects of substrate stiffness, cadherin junction and shear flow on tensional homeostais in cell and cell clusters
(Thesis) Arguer
 Han Xu (candidate nr.216-924-8703) (PhD)
Boston University College of Engineering, United States

Committee member

Activity description
Role 		Institution / Organization
2019/12/13 - Current Founding member of a recent transversal proposal for a CDH1 Working Group (CWG) focused on breast cancer management. Establishment of this working group arose in the context of the «Hereditary Breast and Gastric Cancers: Prevention, Genetics and Care» meeting held on the 13th of December 2019 at the European Institute of Oncology (IEO), Milan, Italy. J FIGUEIREDO is responsible to determine the functional relevance of CDH1 missense variants identified in the breast cancer setting.
Member
 European Institute of Oncology (IEO), Italy
2016/05 - 2023/06 Contact reference and team member of a CDH1 Expert Working Group from ClinGen, a NIH-funded resource dedicated to building an authoritative central that defines the clinical relevance of genes and variants for use in precision medicine and research. https://www.clinicalgenome.org/working-groups/clinical-domain/hereditary-cancer-clinical-domain-working-group/cdh1-variant-curation-expert-panel/
Member
 CDH1 Expert Working Group - ClinGen, United States

Conference scientific committee

Conference name Conference host
2024/06/13 - 2024/06/15 5th INTERNATIONAL GASTRIC CANCER LINKAGE CONSORTIUM (IGCLC) MEETING International Gastric Cancer Linkage Consortium-IGCLC
2023/11/16 - 2023/11/17 10th i3S ANNUAL MEETING Axis Vermar Conference & Beach Hotel, Póvoa do Varzim
2022/06/30 - 2022/07/01 5th ASPIC INTERNATIONAL CONGRESS IPO - Portuguese Institute of Oncology, Porto
2021/08/16 - 2021/11/30 4th PhDay - BREAK BORDERS, BUILD OPPORTUNITIES i3S - Institute for Research and Innovation in Health, University of Porto
2018/04/26 - 2018/04/27 25th Porto Cancer Meeting - CANCER WARS: THE IMMUNE FORCE AWAKENS i3S - Institute for Research and Innovation in Health, University of Porto.
2017/05/11 - 2017/05/12 24th Porto Cancer Meeting - LIQUID BIOPSY: BRINGING PRECISION MEDICINE CLOSER TO ONCOLOGY i3S - Institute for Research and Innovation in Health, University of Porto

Consulting

Activity description Institution / Organization
2011/01 - Current J FIGUEIREDO is the person in charge to evaluate the functional significance of germline missense variants for the International Gastric Cancer Linkage Consortium (IGCLC). International Gastric Cancer Linkage Consortium, United Kingdom

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2025/02/21 - 2025/06/27 Specialized lecture on "Interpretation and clinical contextualization of genetic variants" Molecular diagnostics in pathology and oncology – Postgraduate course | 3rd Edition (Pós-Graduação) Universidade do Porto Faculdade de Medicina, Portugal
2024/02/16 - 2024/06/28 Specialized lecture on "Interpretation and clinical contextualization of genetic variants" Molecular diagnostics in pathology and oncology - Postgraduate course | 2nd Edition (Pós-Graduação) Universidade do Porto Faculdade de Medicina, Portugal
2023/03/17 - 2023/06/02 Specialized lecture on "Interpretation and clinical contextualization of genetic variants" Molecular diagnostics in pathology and oncology - Postgraduate course | 1st Edition (Pós-Graduação) Universidade do Porto Faculdade de Medicina, Portugal
2021/03/15 - 2021/03/16 Specialized lecture on "Clinical Interpretation of Missense Mutations" (Module I) Master's Degree Program of II Level on Prevention, Genetics, and Treatment of Hereditary Breast Cancer (Master) University of Milan "La Statale", Italy
2016/02 - 2019 Oncobiology module - Cancer cell invasion Graduate Program in Areas of Basic and Applied Biology (GABBA PhD Program) Universidade do Porto, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021/04 - 2023/06 Member of the committee responsible for the acquisition of state of the art technologies within the scope of the strategic plan of the Porto Comprehensive Cancer Centre (PCCC). PCCC is a consortium that aims to support the development of precision cancer medicine in Europe, incorporating several health and research institutions, namely Instituto de Investigação e Inovação em Saúde - Universidade do Porto (i3S).
Member
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/07 - 2022/08 Grant proposal reviewer for The Netherlands Organization for Health Research and Development - ZonMw, Clinical Fellows programme 2021, Hague, The Netherlands.
Evaluator
 ZonMw, Netherlands ZonMw
2022/07 - 2022/08 Grant proposal reviewer for The Dutch Cancer Society - KWF, KWF call 2022-4 Exploration, Kankerbestrijding, The Netherlands. Reviewer of project proposals within the scope of cancer research.
Evaluator
 The Dutch Cancer Society - KWF Kankerbestrijding, Netherlands The Dutch Cancer Society - KWF Kankerbestrijding
2021/07/30 - 2021/09/06 Evaluation committee member for The Dutch Cancer Society (KWF Kankerbestrijding) - KWF Programme Research & Implementation. Reviewer of project proposals within the scope of cancer research.
Evaluator
 The Dutch Cancer Society - KWF Kankerbestrijding, Netherlands The Dutch Cancer Society - KWF Kankerbestrijding
2017/05/30 - 2017/05/31 Evaluation committee member of the prospectus defense from Han Xu (PhD Candidate nr.216-924-8703). Thesis entitled "Effects of intercellular interaction through Cadherin on endothelial and epithelial tensional homeostasis".
Evaluator
 Boston University College of Engineering, United States National Science Foundation Directorate for Engineering

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2024/09/18 Bridging the gap in epithelial closure ASPIC - Portuguese Association for Cancer Research
2021/03/11 American association funds i3S research in gastric cancer Notícias Universidade do Porto
2020/10/30 Study establishes guidelines to deal with rare gastric cancer syndrome ASPIC - Portuguese Association for Cancer Research
2020/08/31 i3S researchers define guidelines for rare gastric cancer syndrome Notícias Universidade do Porto
2018/10/18 New molecular mechanism to explain cases of hereditary gastric cancer ASPIC - Portuguese Association for Cancer Research
2018/01/18 Doctors and researchers of the future in Portugal. They are less than 40 years old and the gurus of these areas have chosen them as the most promising. They will change many lives. Know who the 25 elected are. Revista Sábado (Magazine)
2018/01/12 Multidisciplinary research presents a new protocol for the functional characterization of missense type mutations in the gene coding for the adhesion molecule E-cadherin. ASPIC - Portuguese Association for Cancer Research
2017/08/22 Portuguese project investigating gastric cancer financed by American association for the second time myONCOLOGIA
2017/08/14 i3S provides free diagnosis of gastric cancer worldwide. Notícias Universidade do Porto
2017/08/14 Porto research in the area of cancer wins US funding Jornal de Notícias
2017/08/14 Gastric Cancer Research - Highlights National Health Service
2015/05/05 Ipatimup researchers distinguished in the United States Notícias Universidade do Porto

Interview (tv / radio show)

Program Topic
2017/08/22 - 2017/08/22 RTP News Unique investigation into the genetic screening of hereditary stomach cancer is carried out at the University of Porto

Journal scientific committee

Journal title (ISSN) Publisher
2024/11 - Current Biomolecules and Biomedicine - REVIEWER (2831-0896) Assoc Basic Medical Sci Federation
2023/11 - Current Genetics in Medicine - REVIEWER (1098-3600) Elsevier Science Inc
2023/10 - Current Discover Oncology - REVIEWER (2730-6011) Springer
2023/07 - Current JCO Precision Oncology - REVIEWER (2473-4284) Lippincott Williams & Wilkins
2022/11 - Current Advanced Science - REVIEWER (2198-3844) WILEY
2022/05 - Current European Journal of Cancer Prevention - ACADEMIC EDITOR (0959-8278) Lippincott Williams &Wilkins
2022/04 - Current Frontiers in Oncology - REVIEW EDITOR (2234-943X) Frontiers
2022/04 - Current Canadian J of Gastroenterology Hepatology - REVIEWER (2291-2789) Hindawi Limited
2021/12 - Current Frontiers in Gastroenterology - REVIEW EDITOR Frontiers
2021/01 - Current The Journal of Pathology - REVIEWER (1096-9896) Wiley Online Library
2020/10 - Current Cancers (Basel) - REVIEWER (2072-6694) MDPI
2020/10 - Current Histology and Histopathology - REVIEWER (0213-3911) University of Murcia
2020/09 - Current European Journal of Human Genetics - REVIEWER (1018-4813) Nature Publishing Group
2020/01 - Current Molecular Cancer - REVIEWER (1476-4598) Biomed Central Ltd.
2020/01 - Current Scientific Reports - REVIEWER (2045-2322) Springer Science and Business Media LLC
2019/05 - Current Oncotarget - REVIEWER (1949-2553) Impact Journals, LLC
2018/12 - Current Gastric Cancer - REVIEWER (1436-3305) Springer-Verlag
2018/07 - Current Biomaterials - REVIEWER (0142-9612) Elsevier
2018/01 - Current European Journal of Cancer Prevention - REVIEWER (0959-8278) Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
2018/01 - Current Familial Cancer - REVIEWER (1573-7292) Springer-Verlag
2017/10 - Current Acta Gastro-Enterologica Belgica - REVIEWER Acta Medica Belgica
2015/09 - Current Cell and Tissue Research - REVIEWER (1432-0878) Springer-Verlag
2015/09 - Current Pharmacological Reports - REVIEWER (2299-5684) Springer-Verlag
2014/12 - Current Expert Opinion on Therapeutic Targets - REVIEWER (1744-7631) Informa UK (Taylor & Francis)
2014/06 - Current PLoS ONE - REVIEWER (1932-6203) Public Library of Science
2014/05 - Current BMC Cancer - REVIEWER (1471-2407) Springer (Biomed Central Ltd.)
2014/02 - Current Journal of Cellular Biochemistry - REVIEWER (1097-4644) Wiley (John Wiley & Sons)
2021/04 - 2022/12 Cancers - Adhesive Networks in Cancer - GUEST EDITOR (2072-6694) MDPI

Mentoring / Tutoring

Topic Student name
2011/09 - 2011/12 E-cadherin Functional Assays Rodrigo Figueiredo
2010/07 - 2010/08 Ciência Viva Program - Edition 2010 Rita Batista and Tânia Lima
2008/07 - 2008/08 Ciência Viva Program - Edition 2008 Sandra Jiménez and Vanessa Moura
2007/07 - 2007/08 Ciência Viva Program - Edition 2007 Débora Sousa and André Silva
Distinctions

Award

2015 Research award of 25.000 Euros for the project - Today´s present, tomorrow´s future on the study of germline E-cadherin missense mutations.
No Stomach For Cancer, United States

Other distinction

2018 Nominated as one of the Top25 under-40 researchers in the Portuguese scientific community by Revista Sábado (Grupo Cofina).