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Identification

Personal identification

Full name
Sónia Daniel Glória Simão

Citation names

  • Simão, Sónia
  • Simão, S

Author identifiers

Ciência ID
C612-D462-A564
ORCID iD
0000-0002-0238-6395
Google Scholar ID
https://scholar.google.com/citations?hl=pt-PT&user=VLL3QD4AAAAJ&view_op=list_works&sortby=pubdate
Scopus Author Id
983648

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese (Mother tongue)
Education
Degree Classification
2016
Concluded
 Metabolic Diseases and Eating Behavior (Curso de mestrado (conclusão do curso de especialização))
Universidade de Lisboa Faculdade de Medicina, Portugal
2011
Concluded
 Biomedicine (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"Regulation of the Cl- / HCO3- (Slc26a6) exchanger in a genetic model of hypertension" (THESIS/DISSERTATION)
2004
Concluded
 Biochemistry (Licenciatura)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Susceptibility of rabbit skeletal muscle myosin sub-fragment 1 to peroxynitrite" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2020 - Current Researcher (Research) Algarve Biomedical Center Research Institute - ABC-RI, Portugal
Algarve Biomedical Center Research Institute - ABC-RI, Portugal
2016 - Current Researcher (Research) Algarve Biomedical Center - ABC, Portugal
2019 - 2025 Auxiliary Researcher (Research) Universidade do Algarve, Portugal
2015 - 2020 Researcher (Research) Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
2012 - 2017 Postdoc (Research) Universidade do Algarve, Portugal
2005 - 2007 Researcher (Research) Universidade do Porto, Portugal
2003 - 2004 Research Trainee (Research) Universidade do Algarve, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2025 - Current Invited Assistant Professor (University Teacher) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2013 - 2019 Invited Assistant Professor (University Teacher) Universidade do Algarve, Portugal

Others

Category
Host institution 		Employer
2017 - Current Coordinator Investigator for Animal Experimentation Direcção-Geral de Alimentação e Veterinária (DGAV), Portugal
2022/05 - 2023/01 Maternity Leave Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2018/04 - 2019/02 Maternity Leave Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
Projects

Contract

Designation Funders
2021 - Current ABC coLAB: ABC Collaborative Laboratory: Integrated Aging and Rejuvenation Solutions
ABC colab
Researcher
Fundação para a Ciência e a Tecnologia
2024 - 2026 T21S-SH – Tackling impaired neurodevelopment in Down Syndrome via identification of S-sulfhydration targets: a new role for the gasotransmitter hydrogen sulfide signaling in neurodevelopment
2379-GRT-2024A
Researcher
Fondation Jérôme Lejeune
2022 - 2024 Identification of S-sulfhydration targets in Down Syndrome: the role of gasotransmitter hydrogen sulfide (H2S) signaling in neurodevelopment
EXPL/MED-NEU/1240/2021
Researcher
Fundação para a Ciência e a Tecnologia
2022 - 2024 SNO-PD: Contribution of S-Niitrosylation for the aggregation of alfa-synuclein in Parkinson's disease
2021.09515.CBM
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2021 - 2024 ALgarve Fit Ageing (ALFA) Score: uma nova ferramenta integrada para melhorar a qualidade de vida e o envelhecimento saudável
SAICT-2020-072586
Researcher
Algarve Biomedical Center Research Institute - ABC-RI, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Algarve
Ongoing
2020 - 2022 SPINY: Identifying and Modulating the Mechanisms Responsible for Functional Recovery and Axon Regeneration of the Injured Acomys Spinal Cord
MC-39-2019
Researcher
Santa Casa da Misericórdia de Lisboa
Ongoing
2018 - 2021 GT-LightUP: Signaling Gasotransmitters Light Up
PTDC/QUI-QFI/29319/2017
Researcher
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2014/01/01 - 2015 RASRET - Role of the renin-angiotensin system in retinal diseases and its therapeutic potential
EXPL/BIM-MEC/1433/2013
Researcher
Universidade do Algarve, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2013 Regulatory effects of pattern recognition receptors (prrs) in electrolyte transport and membrane potential in intestinal epithelial cells
PTDC/SAU-TOX/117664/2010
Researcher
Universidade do Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007 - 2010 Oxidative stress and genetic markers of cardiovascular risk in hypertension
PIC/IC/83204/2007
Researcher
Universidade do Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2004 - 2007 Antinatriuretic agents and the renal bicarbonate handling in hypertension
POCI/SAU-OBS/59207/2004
Research Fellow
Universidade do Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Simão, Sónia. "ACE2-overexpression protects RPE cells from inflammation and oxidative stress". Paper presented in 2021 ARVO Annual Meeting, 2021.
  2. Simão, Sónia. "Peroxynitrite versus decavanadate protein oxidative modifications: the case of myosin". Paper presented in 19th biennial meeting for the Society for Free Radical Research International (SFRRI), Lisboa, 2018.
    Published
  3. Simão, Sónia. "Deregulation of the retinal renin-angiotensin system precedes the onset of diabetic retinopathy". Paper presented in 53rd EASD Annual Meeting, Lisboa, 2017.
    Published
  4. Simão, Sónia. "Increased expression of (pro)renin and (pro)renin receptor correlates with the progression of diabetic retinopathy". Paper presented in 16th EURETINA Congress, copenhaga, 2016.
    Published
  5. Simão, Sónia. "Hyperglycemia and hypoxia induce overexpression of GLUT1 in models of Diabetic Retinopathy". Paper presented in 51st EASD Annual Meeting, estocolmo, 2015.
    Published
  6. Simão, Sónia. "The role of GLUT1 in the pathogenesis of Diabetic Retinopathy". Paper presented in ESGCT and FSGT Collaborative Congress, Elsinquia, 2015.
    Published
  7. Simão, Sónia. "Anti-angiogenic VEFG isoform is markedly decreased in the retina of diabetic mice". Paper presented in ESGCT and NVGCT Collaborative Congress, Haia, 2014.
    Published
  8. Simão, Sónia. "Insights on the role of the Renin-Angiotensin System in diabetic retinopathy". Paper presented in ESGCT and NVGCT Collaborative Congress, Haia, 2014.
    Published
  9. Simão, Sónia. "Renin is expressed in D407 human retinal cells". Paper presented in European Society of Hypertension and International Society of Hypertension, Atenas, 2014.
    Published
  10. Simão, Sónia. "Glucose and H2O2 modulate the expression of VEGF isoforms in human retinal cells". Paper presented in ESGCT and SETGC Collaborative Congress, Madrid, 2013.
  11. Simão, Sónia. "Carotenoid-based lipoplexes efficiently transfect retinal pigment epithelium cells". Paper presented in ESGCT and SETGC Collaborative Congress, Madrid, 2013.
  12. Simão, Sónia. "pEPito-based vectors enable long-term expression in mouse models of diabetic retinopathy". Paper presented in ESGCT and SETGC Collaborative Congress, Madrid, 2013.
  13. Simão, Sónia. "H2O2 modulates the expression of VEGF isoforms in retinal cells". Paper presented in ESGCT and SFTCG Collaborative Congress, Versailles, 2012.
  14. Simão, Sónia. "H2O2 Increases Cl-/HCO3- Exchanger Activity through Oxidation of Thiol Groups in Spontaneously Hypertensive Rats Renal Cells". Paper presented in Annual High Blood Pressure Research Conference, Orlando, 2011.
    Published
  15. Simão, Sónia. "Isolated Systolic Hypertension in Old WKY Rats is Associated With Oxidative Stress and Metabolic Derangements: Effect of Dietary Restriction". Paper presented in Annual High Blood Pressure Research Conference, Orlando, 2011.
    Published
  16. Simão, Sónia. "Slc26 Transporters Involved in Cl-/HCO3- Exchange Activity in Wistar Kyoto and Spontaneously Hypertensive Rats Proximal Tubular Epithelial Cells". Paper presented in Annual High Blood Pressure Research Conference, Orlando, 2011.
    Published
  17. Simão, Sónia. "The Renal Dopaminergic System and Amino Acid Transporter Expression in Aged WKY and SHR Rats". Paper presented in European Meeting on Hypertension, Milan, 2011.
    Published
  18. Simão, Sónia. "Enhanced Susceptibility to Oxidative Stress Induced Cell Death in SHR is Linked to Reduced Catalase Activity and Increased JNK Activation". Paper presented in European Meeting on Hypertension, Milan, 2011.
    Published
  19. Simão, Sónia. "Oxidative stress and renal mineralcorticoid receptor expression in aged wistar kyoto (WKY) and spontaneously hypertensive (SHR) rats". Paper presented in 19th European Meeting on Hypertension, Milan, 2009.
    Published
  20. Simão, Sónia. "Lack of effect of antioxidant therapy with apocynin, a NADPH oxidase inhibitor, against oxidative stress and elevated blood pressure in SHR rats". Paper presented in 19th European Meeting on Hypertension, Milan, 2009.
    Published
  21. Simão, Sónia. "Aging and Na,K-ATPase activity and expression in kidney and jejunum of normotensive and spontaneously hypertensive rats". Paper presented in 19th European Meeting on Hypertension, Milan, 2009.
    Published
  22. Simão, Sónia. "Differences in H2O2-Induced Stimulation of Cl-/HCO3- Exchanger Activity in WKY and SHR Immortalized Renal Proximal Tubular Cells". Paper presented in 19th European Meeting on Hypertension, Milan, 2009.
    Published
  23. Simão, Sónia. "Unique Profile In Renal Mineralocorticoid Receptor Expression Change In Aged Spontaneously Hypertensive Rats". Paper presented in 63rd Annual High Blood Pressure Research Conference, Chicago, 2009.
    Published
  24. Simão, Sónia. "Effect Of Food Restriciton Upon Mineralocorticoid Receptor Expression And Function In Young And Aged Wistar Kyoto Rats". Paper presented in 63rd Annual High Blood Pressure Research Conference, Chicago, 2009.
    Published
  25. Simão, Sónia. "Resistance of immortalized renal cells from WKY and SHR rats to oxidative stress is associated with activation of multiple MAPK signaling pathways". Paper presented in 18th European Meeting on Hypertension, Berlin, 2008.
    Published
  26. Simão, Sónia. "Oxidative Stress Plays a Permissive Role in a1-AR-Induced Stimulation of Cl-/HCO3- Exchanger in Immortalized SHR Proximal Tubular Epithelial Cells". Paper presented in 18th European Meeting on Hypertension, Berlin, 2008.
    Published
  27. Simão, Sónia. "Involvement of H2O2 in Norepinephrine-Induced Stimulation of Cl-/HCO3- Exchanger Activity in Immortalized SHR Cells". Paper presented in 61st Annual High Blood Pressure Research Conference, Tucson, 2007.
  28. Simão, Sónia. "Norepinephrine-Induced Stimulation of Cl-/HCO3- Exchanger Activity through alpha1-Adrenergic Receptors in Immortalized Proximal Tubular Epithelial Cells from Spontaneously Hypertensive Rats". Paper presented in 17th European Meeting on Hypertension, Milan, 2007.
    Published
  29. Simão, Sónia. "a2-AR Stimulation and Cl-/HCO3- Exchanger Activity in Immortalized Proximal Tubular Epithelial Cells from Spontaneously Hypertensive Rats". Paper presented in 17th European Meeting Hypertension, Milan, 2007.
    Published
  30. Simão, Sónia. "Oxidative Stress and a2-Adrenoceptor-mediated Events in Immortalized Proximal Tubular Epithelial Cells from the Spontaneously Hypertensive Rat". Paper presented in 61st Annual High Blood Pressure Research Conference, Tucson, 2007.
    Published
  31. Simão, Sónia. "Role of PKC on the regulation of enhanced Cl-/HCO3- exchanger activity in hypertension". Paper presented in XLIII ERA-EDTA Congress, Glasgow, 2006.
  32. Simão, Sónia. "Norepinephrine and Cl-/HCO3- Exchanger Activity in Immortalized SHR cells". Paper presented in XLIII ERA-EDTA Congress, Glasgow, 2006.
    Published
Conference poster
  1. Simão, Sónia. "Oxidative profile of a cohort of young versus aged individuals in the Algarve region". Paper presented in HEAT-NET Frontiers in Neurodegeneration: from bench to bedside, 2024.
  2. Simão, Sónia. "Cystathionine beta-synthase and H2S levels are increased in cellular models of trisomy 21". Paper presented in FENS Forum 2024, 2024.
  3. Simão, Sónia. "Characterization of Adult Neurogenesis in Acomys cahirinus by Lineage Tracing Analysis". Paper presented in IX Clinical Biochemistry Workshop, 2024.
  4. Simão, Sónia. "Dysregulation of H2S levels in a cellular model of Down Syndrome". Paper presented in IX Clinical Biochemistry Workshop, 2024.
  5. Simão, Sónia. "Illuminating Neurogenesis: Unveiling Acomys cahirinus newborn neurons by lineage tracing imaging". Paper presented in Spanish & Portuguese Advanced Optical Microscopy Meeting, 2023.
  6. Simão, Sónia. "Assessment of H2S production in fibroblasts by time-lapse fluorescence imaging prior to establishment of fibroblast-derived iPS cell lines". Paper presented in Spanish & Portuguese Advanced Optical Microscopy Meeting, 2023.
  7. Simão, Sónia. "Redox profiling of a cohort of young versus old individuals in the Algarve region". Paper presented in 1st FEBS Redox Medicine Workshop: from cellular signaling to systems physiology and therapeutic targets, 2023.
  8. Simão, Sónia. "New model of brain disorders in Acomys cahirinus: from brain mapping to accurate stereotaxic coordinates". Paper presented in FENS Regional Meeting, 2023.
  9. Simão, Sónia. "Characterization and modulation of H2S production in fibroblasts derived from Down Syndrome individuals by time-lapse fluorescence imaging". Paper presented in FENS Regional Meeting, 2023.
  10. Simão, Sónia. "Brain Atlas of Acomys cahirinus: Creating tools to study brain regeneration". Paper presented in VII Symposium Portuguese Glial Network, 2023.
  11. Santos, Daniela F.; Simão, Sónia; Silva, Nádia; Brito, David V.C.; Clévio Nobrega; Bragança, José; Pedro Castelo-Branco; Araújo, Inês Maria. "Redox profiling of a cohort of young versus medically assisted aged individuals in the Algarve region.". Paper presented in 1st FEBS Redox Medicine Workshop: from cellular signaling to systems physiology and therapeutic targets, 2023.
  12. Simão, Sónia. "Brain Atlas of Acomys cahirinus: a new tool for regenerative studies". Paper presented in Ageing without borders, 2022.
  13. Rajado, Ana Teresa; Raquel P. Andrade; Apolónio, Joana ; Inês Maria Pombinho de Araújo; Brito, David V.C.; Sofia M. Calado; Esteves, Filipa; et al. "ALFA Score - Algarve Fit Ageing Score". Paper presented in ABC-Days, 2022.
  14. Simão, Sónia. "New corrole-based H2S fluorescent probes for time-lapse imaging in cultured cells". Paper presented in IV Jornadas Algarve Biomedical Center, 2021.
  15. Simão, Sónia. "ACE2-overexpression protects RPE cells from inflammation and oxidative stress". Paper presented in 2021 ARVO Annual Meeting, 2021.
  16. Simão, Sónia. "Rewired glycosyltransferase activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection". Paper presented in Encontro Ciência 2021, 2021.
  17. Simão, Sónia. "Peroxynitrite versus decavanadate protein oxidative modifications: the case of myosin". Paper presented in 19th biennial meeting for the Society for Free Radical Research International (SFRRI), 2018.
  18. Simão, Sónia. "Deregulation of the retinal renin-angiotensin system precedes the onset of diabetic retinopathy". Paper presented in 2nd Annual CBMR Meeting, 2017.
  19. Simão, Sónia. "Hyperglycemia modulates the renin-angiotensin system in retinal pigment epithelial cells". Paper presented in 1st Annual CBMR Meeting, 2016.
  20. Simão, Sónia. "Identification of neurogenic S-­nitrosylation targets in neural stem cells". Paper presented in 1st Annual CBMR Meeting, 2016.
  21. Simão, Sónia. "Hybrid strategies for retinal gene therapy". Paper presented in 8th Intern Meeting of the Portuguese Soc. Stem Cells & Cell Therapies, 2013.
  22. Simão, Sónia. "Activation of the aldosterone/MR system by aging in spontaneously hypertensive rats". Paper presented in European Society of Hypertension (ESH) 2012: 22nd European Meeting on Hypertension and Cardiovascular Protection, 2012.
  23. Simão, Sónia. "Increased Responsiveness to JNK1/2 Mediates the Enhanced H2O2-Induced Stimulation of Cl-/HCO3- Exchanger Activity in SHR PTE cells". Paper presented in 4thNational Meeting on Signal Transduction SINAL, 2010.
  24. Simão, Sónia. "Increased susceptibility of renal cells from SHR to H2O2 is associated with activation of multiple MAPK signaling pathways and impaired antioxidant/oxidant balance". Paper presented in Gordon Research Conferences – Oxigen Radicals, 2008.
  25. Simão, Sónia. "Skeletal Muscle Myosin-S1 Susceptibility to Peroxynitrite". Paper presented in XIV Congresso Nacional de Bioquímica, 2004.
    10.1183/13993003.congress-2019.pa4309
  26. Simão, Sónia. "Free-Radical Mediated Effects on Myosin and Actin from Skeletal Muscle". Paper presented in 1st Luso-Spanish Congress on Free Radicals, 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine, 2003.
Journal article
  1. Esteves, Filipa; Vilhena Catarino Brito, David; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vânia; Andrade, Raquel; et al. "Establishment of an induced pluripotent cell line (ABCRIi001-A) from an elderly female for ageing research". Stem Cell Research 81 (2024): 103576.
    Open access • 10.1016/j.scr.2024.103576
  2. Santos, Daniela F.; Simão, Sónia; Nóbrega, Clévio; Bragança, José; Castelo-Branco, Pedro; Araújo, Inês M.; ALFA Score Consortium. "Oxidative stress and aging: synergies for age related diseases". FEBS Letters (2024): http://dx.doi.org/10.1002/1873-3468.14995.
    10.1002/1873-3468.14995
  3. Filipa Esteves; David Brito; Ana Teresa Rajado; Nádia Silva; Joana Apolónio; Vânia Palma Roberto; Inês Araújo; et al. "Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials". Mechanisms of Ageing and Development 214 (2023): 111854.
    Open access • 10.1016/j.mad.2023.111854
  4. Simão, Sónia; Agostinho, Rafaela Ribeiro; Martínez-Ruiz, Antonio; Araújo, Inês Maria. Corresponding author: Simão, Sónia. "Regulation of Ras Signaling by S-Nitrosylation". Antioxidants 12 8 (2023): 1562. http://dx.doi.org/10.3390/antiox12081562.
    Published • 10.3390/antiox12081562
  5. Santos, Carla I.M.; Santiago, Ana M.; Araújo, Ana R.L.; Pinto, Sandra; Agostinho, Rafaela R.; Simão, Sónia; Azevedo, Tomás P.; et al. "New fluorescent probes based on gallium(III) corrole complexes for the recognition of hydrogen sulfide: A journey from solution to intracellular site". Dyes and Pigments 216 (2023): 111304. http://dx.doi.org/10.1016/j.dyepig.2023.111304.
    Published • 10.1016/j.dyepig.2023.111304
  6. Silva, Nádia; Rajado, Ana Teresa; Esteves, Filipa; Brito, David V.C.; Apolónio, Joana; Roberto, Vânia; Binnie, Alexandra; et al. "Measuring healthy ageing: current and future tools". Biogerontology 24 6 (2023): 845.
    Open access • Published
  7. Rajado, Ana Teresa; Silva, Nádia; Esteves, Filipa; Brito, David; Binnie, Alexandra; Araújo, Inês M.; Nóbrega, Clévio; et al. "How can we modulate aging through nutrition and physical exercise? An epigenetic approach". Aging (2023): http://dx.doi.org/10.18632/aging.204668.
    Published • 10.18632/aging.204668
  8. D V C, Brito; F, Esteves; A T, Rajado; N, Silva; I, Araújo; J, Bragança; P, Castelo-Branco; A, Sardo; Simão, Sónia. "Assessing cognitive decline in the aging brain: lessons from rodent and human studies.". npj aging 9 (2023):
  9. Vitorino, Marta; Simão, Sónia; Moreira, João B.; Nogueira-Rodrigues, Joana; Silva, Joana; Lourenço, Ana Sofia; Fernandes, Vítor; et al. "Coronal brain atlas in stereotaxic coordinates of the African spiny mouse, Acomys cahirinus". Journal of Comparative Neurology 530 12 (2022): 2215-2237. http://dx.doi.org/10.1002/cne.25329.
    Published • 10.1002/cne.25329
  10. Nogueira-Rodrigues, Joana; Leite, Sérgio C.; Pinto-Costa, Rita; Sousa, Sara C.; Luz, Liliana L.; Sintra, Maria A.; Oliveira, Raquel; et al. "Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection". Developmental Cell 57 4 (2022): 440-450.e7. http://dx.doi.org/10.1016/j.devcel.2021.12.008.
    Published • 10.1016/j.devcel.2021.12.008
  11. Bitoque, Diogo B.; Morais, Joana; Oliveira, Ana V.; Sequeira, Raquel L.; Calado, Sofia M.; Fortunato, Tiago M.; Simão, Sónia; Rosa da Costa, Ana M.; Silva, Gabriela A.. "Human-derived NLS enhance the gene transfer efficiency of chitosan". Bioscience Reports 41 1 (2021): http://dx.doi.org/10.1042/bsr20201026.
    Published • 10.1042/bsr20201026
  12. Santos, Ana Isabel; Lourenço, Ana Sofia; Simão, Sónia; Marques da Silva, Dorinda; Santos, Daniela Filipa; Onofre de Carvalho, Ana Paula; Pereira, Ana Catarina; et al. "Identification of new targets of S-nitrosylation in neural stem cells by thiol redox proteomics". Redox Biology 32 (2020): 101457. http://dx.doi.org/10.1016/j.redox.2020.101457.
    Published • 10.1016/j.redox.2020.101457
  13. Simão, Sónia; Santos, Daniela F.; Silva, Gabriela A.. "Aliskiren decreases oxidative stress and angiogenic markers in retinal pigment epithelium cells". Angiogenesis 20 1 (2017): 175-181. http://dx.doi.org/10.1007/s10456-016-9526-5.
    10.1007/s10456-016-9526-5
  14. Simão, Sónia; Santos, Daniela F.; Silva, Gabriela A.. "Aliskiren inhibits the renin-angiotensin system in retinal pigment epithelium cells". European Journal of Pharmaceutical Sciences 92 (2016): 22-27. http://dx.doi.org/10.1016/j.ejps.2016.06.019.
    10.1016/j.ejps.2016.06.019
  15. Sofia M. Calado; Simão, Sónia; B Bitoque, Diogo; M Calado, Sofia; A Silva, Gabriela. "Oxidative stress modulates the expression of VEGF isoforms in models of diabetic retinopathy". New Frontiers in Ophthalmology 2 2 (2016): http://oatext.com/Oxidative-stress-modulates-the-expression-of-VEGF-isoforms-in-the-diabetic-retina.php.
    Published • 10.15761/NFO.1000119
  16. Simão, Sónia. "Oxidative stress modulates the expression of VEGF isoforms in the diabetic retina". New Frontiers in Ophthalmology 2 1 (2016): 77-83. https://oatext.com/Oxidative-stress-modulates-the-expression-of-VEGF-isoforms-in-the-diabetic-retina.php.
    Open access • Published
  17. Simão, Sónia. "GLUT1 activity contributes to the impairment of PEDF secretion by the RPE". Molecular Vision 22 (2016): 761-770. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943856/.
    Open access • Published
  18. Bitoque, Diogo B.; Simão, Sónia; Oliveira, Ana V.; Machado, Susana; Duran, Margarita R.; Lopes, Eduardo; da Costa, Ana M. Rosa; Silva, Gabriela A.. "Efficiency of RAFT-synthesized PDMAEMA in gene transfer to the retina". Journal of Tissue Engineering and Regenerative Medicine 11 1 (2014): 265-275. http://dx.doi.org/10.1002/term.1909.
    10.1002/term.1909
  19. Simão, Sónia; Gomes, Pedro; Pinho, Maria João; Soares-da-Silva, Patrício. "Identification of SLC26A transporters involved in the Cl-/HCO3- exchange in proximal tubular cells from WKY and SHR". Life Sciences 93 12-14 (2013): 435-440. http://dx.doi.org/10.1016/j.lfs.2013.07.026.
    10.1016/j.lfs.2013.07.026
  20. Gomes, Pedro; Simão, Sónia; Lemos, Vera; Amaral, João S.; Soares-da-Silva, Patrício. "Loss of oxidative stress tolerance in hypertension is linked to reduced catalase activity and increased c-Jun NH2-terminal kinase activation". Free Radical Biology and Medicine 56 (2013): 112-122. http://dx.doi.org/10.1016/j.freeradbiomed.2012.11.017.
    10.1016/j.freeradbiomed.2012.11.017
  21. Pinto, Vanda; Pinho, Maria João; Silva, Elisabete; Simão, Sónia; Igreja, Bruno; Afonso, Joana; Serrão, Maria Paula; Gomes, Pedro; Soares-da-Silva, Patrício. "Long-term food restriction attenuates age-related changes in the expression of renal aldosterone-sensitive sodium transporters in Wistar-Kyoto rats: A comparison with SHR". Experimental Gerontology 47 8 (2012): 644-653. http://dx.doi.org/10.1016/j.exger.2012.05.022.
    10.1016/j.exger.2012.05.022
  22. Simão, Sónia; Gomes, Pedro; Pinho, Maria João; Soares-da-Silva, Patrício. "H2O2 stimulates Cl-/HCO¿3- exchanger activity through oxidation of thiol groups in immortalized SHR renal proximal tubular epithelial cells". Journal of Cellular Biochemistry 112 12 (2011): 3660-3665. http://dx.doi.org/10.1002/jcb.23299.
    10.1002/jcb.23299
  23. Pinto, Vanda; Amaral, João; Silva, Elisabete; Simão, Sónia; Cabral, José Miguel; Afonso, Joana; Serrão, Maria Paula; et al. "Age-related changes in the renal dopaminergic system and expression of renal amino acid transporters in WKY and SHR rats". Mechanisms of Ageing and Development 132 6-7 (2011): 298-304. http://dx.doi.org/10.1016/j.mad.2011.06.003.
    10.1016/j.mad.2011.06.003
  24. Simão, Sónia; Gomes, Pedro; Pinto, Vanda; Silva, Elisabete; Amaral, João S.; Igreja, Bruno; Afonso, Joana; et al. "Age-related changes in renal expression of oxidant and antioxidant enzymes and oxidative stress markers in male SHR and WKY rats". Experimental Gerontology 46 6 (2011): 468-474. http://dx.doi.org/10.1016/j.exger.2011.02.003.
    10.1016/j.exger.2011.02.003
  25. Silva, E.; Pinto, V.; Simão, S.; Serrão, M.P.; Afonso, J.; Amaral, J.; Pinho, M.J.; Gomes, P.; Soares-da-Silva, P.. "Renal aging in WKY rats: Changes in Na+,K+-ATPase function and oxidative stress". Experimental Gerontology 45 12 (2010): 977-983. http://dx.doi.org/10.1016/j.exger.2010.09.012.
    10.1016/j.exger.2010.09.012
  26. Simão, S.; Gomes, P.; Jose, P.A.; Soares-da-Silva, P.. "Increased responsiveness to JNK1/2 mediates the enhanced H2O2-induced stimulation of Cl-/HCO3- exchanger activity in immortalized renal proximal tubular epithelial cells from the SHR". Biochemical Pharmacology 80 6 (2010): 913-919. http://dx.doi.org/10.1016/j.bcp.2010.05.013.
    10.1016/j.bcp.2010.05.013
  27. Simão, S; Fraga, S; Jose, P A; Soares-da-Silva, P. "Oxidative stress and a1-adrenoceptor-mediated stimulation of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells". British Journal of Pharmacology 153 7 (2009): 1445-1455. http://dx.doi.org/10.1038/bjp.2008.16.
    10.1038/bjp.2008.16
  28. Gomes, Pedro; Simão, Sónia; Silva, Elisabete; Pinto, Vanda; Amaral, João S.; Afonso, Joana; Serrão, Maria Paula; Pinho, Maria João; Soares-da-Silva, Patrício. "Aging increases Oxidative Stress and Renal Expression of Oxidant and Antioxidant Enzymes that Are Associated with an Increased Trend in Systolic Blood Pressure". Oxidative Medicine and Cellular Longevity 2 3 (2009): 138-145. http://dx.doi.org/10.4161/oxim.2.3.8819.
    10.4161/oxim.2.3.8819
  29. Simão, Sónia; Pedrosa, Rui; Hopfer, Ulrich; Mount, David B.; Jose, Pedro A.; Soares-da-Silva, Patrício. "Short-term regulation of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells". Biochemical Pharmacology 75 11 (2008): 2224-2233. http://dx.doi.org/10.1016/j.bcp.2008.03.003.
    10.1016/j.bcp.2008.03.003
  30. Simão, Sónia; Fraga, Sónia; Jose, Pedro A.; Soares-da-Silva, Patrício. "Oxidative stress plays a permissive role in a2-adrenoceptor-mediated events in immortalized SHR proximal tubular epithelial cells". Molecular and Cellular Biochemistry 315 1-2 (2008): 31-39. http://dx.doi.org/10.1007/s11010-008-9785-6.
    10.1007/s11010-008-9785-6
  31. Pedrosa, Rui; Villar, Van Anthony M.; Pascua, Annabelle M.; Sima~o, So´nia; Hopfer, Ulrich; Jose, Pedro A.; Soares-da-Silva, Patri´cio. "H 2 O 2 Stimulation of the Cl - /HCO 3 - Exchanger by Angiotensin II and Angiotensin II Type 1 Receptor Distribution in Membrane Microdomains". Hypertension 51 5 (2008): 1332-1338. http://dx.doi.org/10.1161/hypertensionaha.107.102434.
    10.1161/hypertensionaha.107.102434
  32. Tiago, Teresa; Simão, Sónia; Aureliano, Manuel; Martín-Romero, Francisco Javier; Gutiérrez-Merino, Carlos. "Inhibition of Skeletal Muscle S1-Myosin ATPase by Peroxynitrite". Biochemistry 45 11 (2006): 3794-3804. http://dx.doi.org/10.1021/bi0518500.
    10.1021/bi0518500
Magazine article
  1. Simão, Sónia. "Como é que a formação de novos neurónios é estimulada a seguir a uma lesão cerebral provocada por crises epilépticas?", UALgoritmo: a ciência trocada por miúdos, 2021
Thesis / Dissertation
  1. Simão, Sónia. "Regulation of CI/HCO3 Exchanger in a Genetic Model of Hypertension". PhD, Universidade do Porto Faculdade de Medicina, 2011.
  2. Simão, Sónia. "Suscepibility of S1 fragment of myosin from rabbit skeletal muscle to peroxynitrite". Degree, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2004.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/01/26 Redox profiling of a cohort of young versus medically assisted aged individuals in the Algarve region IX Clinical Biochemistry Workshop
(Portugal)
2024/01/26 Contribution of S-nitrosylation of PDI to the aggregation and toxicity of alpha-synuclein in SH-SY5Y cells IX Clinical Biochemistry Workshop
(Portugal)
2023/04/28 Como se constrói um mapa do cérebro? XXX Aniversário do curso de Bioquímica da Universidade do Algarve
2021/10/07 Similar abundance of neural stem cells in the sugranular zone of the hippocampus of Acomys Cahirinus and Mus musculus IV Jornadas ABC
2021 ACE2-overexpression protects RPE cells from inflammation and oxidative stress Pan-American Reserch Day (PARD 2021)
2019 Identification of new targets of S-nitrosylation in neurogenic signaling by thiol redox proteomics SINAL - 10th MEETING in SIGNAL TRANSDUCTION
(Olhão, Portugal)
2015 Gene therapy for the treatment of ocular diseases Jornada Tecnológica (JORTEC) de Química e Bioquímica, Faculdade Ciências Tecnologia – Universidade Nova Lisboa
(Lisboa, Portugal)
2013 Epithelial-Mesenchymal Transition and Renal Salt-Inducible Kinase1 Expression in Spontaneously Hypertensive Rats 23th European Meeting on Hypertension and Cardiovascular Protection
(Milão, Italy)
2011 Age-Related Changes in Renal Oxidative Stress Markers in SHR and WKY Rats XLI Reunião Anual da Soc Portuguesa de Farmacologia
(Coimbra, Portugal)
2009 H2O2-induced stimulation of Cl-/HCO3- exchanger activity in SHR cells is associated with oxidation of exchanger thiol groups XL Reunião Soc Portug Farmac
(Porto, Portugal)
2008 Effect of apocynin on blood pressure and oxidative stress parameters in young WKY and SHR rats British Pharmacological Society
(Brighton, United Kingdom)
2008 H2O2-induced stimulation of Cl-/HCO3- exchanger activity in SHR cells is associated with activation of MAPK XXXIX Reunião Anual Soc Portug Farmacologia
(Lisboa, Portugal)
2008 Effect of Oxidative Stress on a2-AR-Mediated Events in SHR PTE cells XIIth Workshop of the ESH Young Investigator Initiative Group
(Berlin, Germany)
2007 Oxidative stress plays a permissive role in a1-adrenergic receptor-induced stimulation of the Cl-/HCO3- exchanger in immortalized SHR PTE cells XXXVIII Reunião Anual da Soc Portuguesa de Farmacologia
(Coimbra, Portugal)
2007 Involvement of H2O2 in a1-Adrenoceptor-Mediated Stimulation of Cl-/HCO3- Exchanger Activity in Immortalized SHR Proximal, Tubular Epithelial Cells XI Workshop of the European Society of Hypertension Young Investigator Initiative Group
(Milão, Italy)
2006 a1-AR Stimulation and Cl-/HCO3- Exchanger Activity in SHR PTE cells XXXVII Reunião Anual da Soc Portuguesa de Farmacologia
(Porto, Portugal)
2004 Inhibition of Skeletal Muscle S1-Myosin ATPase Activity by the Peroxynitrite-Releasing Agent SIN-1 2nd Spanish and Portuguese Congress on Free Radicals
(Leioa, Spain)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/01/25 - 2024/01/26 IX Clinical Biochemistry Worshop LIFESPAN, HEALTH & METABOLIC DISEASES (2024/01/25 - 2024/01/26)
Congress (Member of the Scientific Committee)
 Universidade do Algarve, Portugal
2023/10/29 - 2023/11/04 ESN-ISN Neurochemistry School (2023/10/29 - 2023/11/04)
Workshop (Member of the Organising Committee)
 Algarve Biomedical Center Research Institute, Portugal
2023/05/03 - 2023/05/03 FENS Regional Meeting 2023 (2023/05/03 - 2023/05/05)
Congress (Member of the Organising Committee)
 Algarve Biomedical Center Research Institute, Portugal
2023/05/02 - 2023/05/02 VII Symposium of the Portuguese Glial Network (2023/05/02 - 2023/05/02)
Congress (Member of the Organising Committee)
 Algarve Biomedical Center Research Institute, Portugal
2021 - 2021 International Stem Cell Awareness Day (2021)
Meeting (Co-organisor)
 Universidade do Algarve Algarve Biomedical Center, Portugal
2020/01/23 - 2020/01/24 INTERNATIONAL MEETING OF THE PORTUGUESE SOCIETY OF GENETICS (2020/01/23 - 2020/01/24)
Congress (Member of the Organising Committee)
 Universidade do Algarve, Portugal

Association member

Society Organization name Role
2021 - Current Sociedade Portuguesa de Neurociências Membro
2017 - Current Sociedade Portuguesa de Diabetologia Membro
2016 - Current Sociedade Portuguesa de Ciências em Animais de Laboratório Membro
2006 - Current Sociedade Portuguesa de Farmacologia Membro

Journal scientific committee

Journal title (ISSN) Publisher
2024 - Current Frontiers in Molecular Neuroscience Frontiers
2024 - Current Frontiers in Bioscience-Landmark (FBL) IMR Press
2023 - Current Antioxidants MDPI
2023 - Current Biomedicines MDPI
2023 - Current NeuroSci MDPI
2018 - Current Journal of the Renin-Angiotensin-Aldosterone System (1752-8976) SAGE Publications
2017 - Current Journal of Physiology and Pharmacology
2016 - Current Kidney and Blood Pressure Research (1423-0143) S. Karger AG
2015 - Current Current Pharmaceutical Design (1381-6128) Bentham Science
Distinctions

Award

2024 Best oral communication: IX Clinical Biochemistry Workshop 2024
2019 CBMR Synergy Award 2019
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
2017 Grant from the Sociedade Portuguesa Diabetologia/Lilly 2017
Sociedade Portuguesa de Diabetologia, Portugal
2016 Janssen Innovation Award 2016 – Honorable mention
Janssen-Cilag Farmacêutica Lda, Portugal
2014 Tebu-bio's Researchers Travel Grant
Tebubio, France
2009 ESH Investigators´ Grants
European Society of Hypertension, Italy
2009 ESH Investigators’ Grants
European Society of Hypertension, Italy
2008 Travel & Accommodation Support, XII Workshop ESH Young Investigator Initiative Group
European Society of Hypertension, Italy
2008 ESH Investigators´ Grants
European Society of Hypertension, Italy
2008 Best Poster Presented by Young Investigator at the 13th International SHR Symposium
The Prague Blood Pressure Foundation, Czech Republic
2007 Travel & Accommodation Support, XI Workshop ESH Young Investigator Initiative Group
European Society of Hypertension, Italy
2007 ESH Investigators´ Grants
European Society of Hypertension, Italy

Other distinction

2011 Postdoctoral fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2007 PhD fellowship
Fundação para a Ciência e a Tecnologia, Portugal