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Quan Zhang is an Associate Professor of Endocrine Cell Physiology at the Radcliffe Department of Medicine of the University of Oxford (UK) and an Investigador Auxiliar (Assistant Researcher) at the Centro de Inovação em Biomedicina e Biotecnologia (CIBB) of the Universidade de Coimbra (Portugal). He completed a Doctor of Philosophy degree in the Department of Clinical Sciences at Lund University in 2008 and a Bachelor's degree in Biology in 2002 at Shandong University. To date, he has worked in 4 international laboratories (Sweden, Canada, Portugal and the UK), published 47 articles in international scientific journals (12 with first authorship and 9 with senior authorship; 22 papers in the past 5 years), reaching an h-index of 31 with a total citation of 3139 (source: Web of Science). He supervised 4 postdoctoral research fellows and co-supervised 4 PhD theses. He secured 9 grants as the Principal Investigator and 3 grants as the Co-Investigator (total grants= 3.3 million euros). He has received 2 national awards (one Swedish and one Chinese) and recently was awarded as an Outstanding Editorial Board Member by the Journal of Chronic Diseases and Translational Medicine. He is a member of the editorial boards of 3 international academic journals (Diabetes, Biology and the Journal of Chronic Diseases and Translational Medicine) and is a regular reviewer for international scientific journals (e.g., Cell Systems, Cell Reports and Diabetes) and research funding bodies (e.g., MRC, BBSRC and Stanford Diabetes Research Center). He has been invited to give seminars/lectures at international conferences (e.g., European Association for the Study of Diabetes Annual Meeting, American Diabetes Annual Meeting and European Society for Clinical Investigation Annual Scientific Meeting) or research institutes (e.g., Cornell University and Gothenburg University). He is a regular organizer of the scientific seminars held at the Oxford Centre for Diabetes, Endocrinology and Metabolism and he participated in one BRC-hosted patient meeting. He is a member of the organising committee of the annual CIBB meeting (2023). He works in the area of Medical and Health Sciences with an emphasis on Basic Medicine and Physiology in particular. He also works on Natural sciences with an emphasis on Biological Sciences, specifically on Biophysics and Cell Biology.
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Identification

Personal identification

Full name
Quan Zhang

Citation names

  • Zhang, Quan

Author identifiers

Ciência ID
C71F-81BE-BD22
ORCID iD
0000-0002-3626-4855

Email addresses

  • quan.zhang@ocdem.ox.ac.uk (Professional)
  • quanzhang@cnc.uc.pt (Professional)

Telephones

Mobile phone
  • (+44) 7427691819 (Personal)
  • (+351) 964293418 (Personal)

Addresses

  • OCDEM, churchill hospital, OX3 7LE, OXFORD, Oxfordshire, United Kingdom (Professional)
  • Centro de Neurociências e Biologia Celular (CNC) Universidade de Coimbra, Pólo I - Edifício da FMUC, Rua Larga, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Physiology
  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Chinese (Mother tongue)
Education
Degree Classification
2003/06/01 - 2008/03/18
Concluded
 Department of Clinical Sciences (Doctor of Philosophy)
Major in Physiology
Lunds Universitet, Sweden
"Cell coupling and exocytosis measured in intact mouse pancreatic islets Control of {delta}-cell secretion" (THESIS/DISSERTATION)
1998/09/01 - 2002/07/01
Concluded
 Biology (Bachelor)
Major in Zoology
Shandong University, China
Affiliation

Science

Category
Host institution 		Employer
2023/01/16 - Current Auxiliary Researcher (Research) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2011/10/01 - 2015/09/01 Postdoc (Research) University of Oxford Radcliffe Department of Medicine, United Kingdom
University of Oxford Radcliffe Department of Medicine, United Kingdom
(...)
2011/05/08 - 2011/10/01 Postdoc (Research) University of Alberta, Canada
University of Alberta, Canada
2008/03/18 - 2011/05/16 Postdoc (Research) Nuffield Department of Clinical Medicine, United Kingdom
Nuffield Department of Clinical Medicine, United Kingdom
(...)

Others

Category
Host institution 		Employer
2023/01/01 - Current Associate Professor of Endocrine Cell Physiology University of Oxford, United Kingdom
2015/09/01 - 2023/01/01 University Research Lecturer University of Oxford Radcliffe Department of Medicine, United Kingdom
University of Oxford Radcliffe Department of Medicine, United Kingdom
(...)
Projects

Grant

Designation Funders
2021/03/01 - 2025/02/28 The role of impaired glucagon secretion in life-threatening hypoglycaemia of type 1 diabetes: mechanism and therapeutic potential
MR/V011979/1
Co-Investigator
University of Oxford Radcliffe Department of Medicine, United Kingdom
 UK Research and Innovation

Medical Research Council Swindon
Ongoing
2022 - 2025 Alpha-cell function in T1D patients with and without severe hypoglycaemia
Hemsley
Co-Principal Investigator (Co-PI)
2023 - 2024 Decipher the mechanisms underlying islet hormone secretory defects in recurrent hypoglycaemia
BRC
Principal investigator
2022 - 2024 Metabolic memory of islet delta cells in defective glucagon secretion in recurrent hypoglycaemia
EFSD
Principal investigator
2018/03/31 - 2022/03/30 Investigation of intra-islet glucagon- somatostatin- glucagon feedback mechanisms
IEC\NSFC\170394
Principal investigator
Oxford Centre for Diabetes Endocrinology and Metabolism, United Kingdom
 The Royal Society
Ongoing
2015/09 - 2022/02 KATP channel-dependent and –independent regulation of the glucagon-secreting pancreatic a-cell
grant.DUK-14/0005128
Principal investigator
Diabetes UK
2018/04/01 - 2021/03/31 Investigation of the role of ER Ca2+ in the glucose regulation of glucagon secretion
n/a
Principal investigator
Oxford Centre for Diabetes Endocrinology and Metabolism, United Kingdom
 European Foundation for the Study of Diabetes
Ongoing
2019/12/01 - 2021/03/30 Paracrine feedback loops in pancreatic islets and their impact in hypoglycaemia
WISSF
Principal investigator
Oxford Centre for Diabetes Endocrinology and Metabolism, United Kingdom
 University of Oxford Medical Sciences Division
Ongoing
2019/02/01 - 2020/05/01 The role of tetraspanin-7 in insulin secretion from pancreatic ß-cells
MSIF
Principal investigator
Oxford Centre for Diabetes Endocrinology and Metabolism, United Kingdom
 University of Oxford Medical Sciences Division
Ongoing
2017/09/01 - 2018/04/01 Developing Fluorescent Bioprobes for Studying Human Pancreatic Alpha Cell Physiology
n/a
Principal investigator
Oxford Centre for Diabetes Endocrinology and Metabolism, United Kingdom
 University of Oxford Radcliffe Department of Medicine
Concluded
2016/04 - 2017/10 Membrane potential independent regulation of glucagon secretion from the pancreatic alpha-cells
152/052
Principal investigator
University of Oxford John Fell Fund
Concluded
Outputs

Publications

Journal article
  1. Samuel Acreman; Jinfang Ma; Geoffrey Denwood; Rui Gao; Andrei Tarasov; Patrik Rorsman; Quan Zhang. "The endoplasmic reticulum plays a key role in a-cell intracellular Ca2+ dynamics and glucose-regulated glucagon secretion in mouse islets". iScience (2024): https://doi.org/10.1016/j.isci.2024.109665.
    10.1016/j.isci.2024.109665
  2. Gandasi, Nikhil R.; Gao, Rui; Kothegala, Lakshmi; Pearce, Abigail; Santos, Cristiano; Acreman, Samuel; Basco, Davide; et al. "GLP-1 metabolite GLP-1(9–36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion". Diabetologia 67 3 (2023): 528-546. http://dx.doi.org/10.1007/s00125-023-06060-w.
    10.1007/s00125-023-06060-w
  3. Zhang, Quan; Huising, Mark O.; Da Silva Xavier, Gabriela; Hauge-Evans, Astrid C.. "Editorial: The pancreatic islet – a multifaceted hub of inter-cellular communication". Frontiers in Endocrinology 14 (2023): http://dx.doi.org/10.3389/fendo.2023.1182897.
    10.3389/fendo.2023.1182897
  4. Rui Gao; Samuel Acreman; Jinfang Ma; Fernando Abdulkader; Anna Wendt; Quan Zhang. "a-cell electrophysiology and the regulation of glucagon secretion". Journal of Endocrinology (2023): https://doi.org/10.1530/JOE-22-0295.
    10.1530/JOE-22-0295
  5. McLaughlin, Kerry; Acreman, Samuel; Nawaz, Sameena; Cutteridge, Joseph; Clark, Anne; Knudsen, Jakob G.; Denwood, Geoffrey; et al. "Loss of tetraspanin-7 expression reduces pancreatic ß-cell exocytosis Ca2+ sensitivity but has limited effect on systemic metabolism". Diabetic Medicine 39 12 (2022): http://dx.doi.org/10.1111/dme.14984.
    10.1111/dme.14984
  6. Yingying Ye; Mohammad Barghouth; Haiqiang Dou; Cheng Luan; Yongzhi Wang; Alexandros Karagiannopoulos; Xiaoping Jiang; et al. "A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic ß-cells". Nature Communications (2022): https://doi.org/10.1038/s41467-022-31103-y.
    10.1038/s41467-022-31103-y
  7. Anna Veprik; Geoffrey Denwood; Dong Liu; Rula Bany Bakar; Valentin Morfin; Kara McHugh; Nchimunya N. Tebeka; et al. Corresponding author: James Cantley. "Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion.". Communications Biology (2022):
    In press
  8. Samuel Acreman; Quan Zhang. "Regulation of a-cell glucagon secretion: The role of second messengers". Chronic Diseases and Translational Medicine (2021): https://doi.org/10.1016/j.cdtm.2021.06.001.
    10.1016/j.cdtm.2021.06.001
  9. Gao R; Fu Q; Jiang HM; Shen M; Zhao RL; Qian Y; He YQ; et al. Corresponding author: Yang T. "Temporal metabolic and transcriptomic characteristics crossing islets and liver reveal dynamic pathophysiology in diet-induced diabetes". iScience 24 4 (2021): 102265-102265. http://dx.doi.org/10.1016/j.isci.2021.102265.
    10.1016/j.isci.2021.102265
  10. Rui Gao; Tao Yang; Quan Zhang. "d-Cells: The Neighborhood Watch in the Islet Community". Biology 10 2 (2021): 74-74. https://doi.org/10.3390/biology10020074.
    10.3390/biology10020074
  11. Oduori, Okechi S.; Murao, Naoya; Shimomura, Kenju; Takahashi, Harumi; Zhang, Quan; Dou, Haiqiang; Sakai, Shihomi; et al. "Gs/Gq signaling switch in ß cells defines incretin effectiveness in diabetes". Journal of Clinical Investigation 130 12 (2020): 6639-6655. http://dx.doi.org/10.1172/jci140046.
    10.1172/jci140046
  12. Quan Zhang; Haiqiang Dou; Patrik Rorsman. "‘Resistance is futile?’ – paradoxical inhibitory effects of K ATP channel closure in glucagon-secreting a-cells". The Journal of Physiology 598 21 (2020): 4765-4780. https://doi.org/10.1113/JP279775.
    10.1113/JP279775
  13. Satin, Leslie S.; Zhang, Quan; Rorsman, Patrik. "“Take Me To Your Leader”: An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets". Diabetes 69 5 (2020): 830-836. http://dx.doi.org/10.2337/dbi19-0012.
    10.2337/dbi19-0012
  14. Quan Zhang; Elisa Vergari; Geoffrey Denwood; Albert Salehi; Julie Adam; Ahmed Alrifaiy; Ingrid Wernstedt Asterholm; et al. "Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta cells". Nature Metabolism (2020): https://doi.org/10.1038/s42255-019-0158-0.
    10.1038/s42255-019-0158-0
  15. Quan Zhang; Elisa Vergari; Jakob G. Knudsen; Reshma Ramracheya; Albert Salehi; Julie Adam; Ingrid Wernstedt Asterholm; et al. "Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion". Nature Communications 10 1 (2019): https://doi.org/10.1038/s41467-018-08193-8.
    10.1038/s41467-018-08193-8
  16. Denwood, Geoffrey; Tarasov, Andrei; Salehi, Albert; Vergari, Elisa; Ramracheya, Reshma; Takahashi, Harumi; Nikolaev, Viacheslav O.; et al. "Glucose stimulates somatostatin secretion in pancreatic d-cells by cAMP-dependent intracellular Ca2+ release". The Journal of General Physiology 151 9 (2019): 1094-1115. http://dx.doi.org/10.1085/jgp.201912351.
    10.1085/jgp.201912351
  17. Knudsen, Jakob G.; Hamilton, Alexander; Ramracheya, Reshma; Tarasov, Andrei I.; Brereton, Melissa; Haythorne, Elizabeth; Chibalina, Margarita V.; et al. "Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production". Cell Metabolism 29 2 (2019): 430-442.e4. http://dx.doi.org/10.1016/j.cmet.2018.10.003.
    10.1016/j.cmet.2018.10.003
  18. Quan Zhang; Davide Basco; Albert Salehi; Andrei Tarasov; Wanda Dolci; Pedro Herrera; Ioannis Spiliotis; et al. "a-cell glucokinase suppresses glucose-regulated glucagon secretion". Nature Communications 9 1 (2018): https://doi.org/10.1038/s41467-018-03034-0.
    10.1038/s41467-018-03034-0
  19. Ramracheya, Reshma; Chapman, Caroline; Chibalina, Margarita; Dou, Haiqiang; Miranda, Caroline; González, Alejandro; Moritoh, Yusuke; et al. "GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca2+ channels". Physiological Reports 6 17 (2018): e13852. http://dx.doi.org/10.14814/phy2.13852.
    10.14814/phy2.13852
  20. Mahdieh Godazgar; Quan Zhang; Margarita V. Chibalina; Patrik Rorsman. "Biphasic voltage-dependent inactivation of human NaV 1.3, 1.6 and 1.7 Na+ channels expressed in rodent insulin-secreting cells". The Journal of Physiology 596 9 (2018): 1601-1626. https://doi.org/10.1113/JP275587.
    10.1113/JP275587
  21. Hamilton, Alexander; Zhang, Quan; Salehi, Albert; Willems, Mara; Knudsen, Jakob G.; Ringgaard, Anna K.; Chapman, Caroline E.; et al. "Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+Mobilization From Acidic Stores in Pancreatic a-Cells". Diabetes 67 6 (2018): 1128-1139. http://dx.doi.org/10.2337/db17-1102.
    10.2337/db17-1102
  22. Quinault, Aurore; Leloup, Corinne; Denwood, Geoffrey; Spiegelhalter, Coralie; Rodriguez, Marianne; Lefebvre, Philippe; Messaddeq, Nadia; et al. "Modulation of large dense core vesicle insulin content mediates rhythmic hormone release from pancreatic beta cells over the 24h cycle". PLOS ONE 13 3 (2018): e0193882. http://dx.doi.org/10.1371/journal.pone.0193882.
    10.1371/journal.pone.0193882
  23. Adam, Julie; Ramracheya, Reshma; Chibalina, Margarita V.; Ternette, Nicola; Hamilton, Alexander; Tarasov, Andrei I.; Zhang, Quan; et al. "Fumarate Hydratase Deletion in Pancreatic ß Cells Leads to Progressive Diabetes". Cell Reports 20 13 (2017): 3135-3148. http://dx.doi.org/10.1016/j.celrep.2017.08.093.
    10.1016/j.celrep.2017.08.093
  24. Zhang, Quan; Babinsky, Valerie N; Hannan, Fadil M; Ramracheya, Reshma D; Nesbit, M Andrew; Hugill, Alison; Bentley, Liz; et al. "Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy". Endocrinology 158 8 (2017): 2486-2502. http://dx.doi.org/10.1210/en.2017-00111.
    10.1210/en.2017-00111
  25. Briant, Linford J. B.; Zhang, Quan; Vergari, Elisa; Kellard, Joely A.; Rodriguez, Blanca; Ashcroft, Frances M.; Rorsman, Patrik. "Functional identification of islet cell types by electrophysiological fingerprinting". Journal of The Royal Society Interface 14 128 (2017): 20160999. http://dx.doi.org/10.1098/rsif.2016.0999.
    10.1098/rsif.2016.0999
  26. Briant, Linford; Salehi, Albert; Vergari, Elisa; Zhang, Quan; Rorsman, Patrik. "Glucagon secretion from pancreatic a-cells". Upsala Journal of Medical Sciences 121 2 (2016): 113-119. http://dx.doi.org/10.3109/03009734.2016.1156789.
    10.3109/03009734.2016.1156789
  27. Brereton, Melissa F.; Vergari, Elisa; Zhang, Quan; Clark, Anne. "Alpha-, Delta- and PP-cells: Are They the Architectural Cornerstones of Islet Structure and Co-ordination?". Journal of Histochemistry & Cytochemistry 63 8 (2015): 575-591. http://dx.doi.org/10.1369/0022155415583535.
    10.1369/0022155415583535
  28. Arredouani, Abdelilah; Ruas, Margarida; Collins, Stephan C.; Parkesh, Raman; Clough, Frederick; Pillinger, Toby; Coltart, George; et al. "Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic ß Cells". Journal of Biological Chemistry 290 35 (2015): 21376-21392. http://dx.doi.org/10.1074/jbc.m115.671248.
    10.1074/jbc.m115.671248
  29. Zhang, Quan; Chibalina, Margarita V.; Bengtsson, Martin; Groschner, Lukas N.; Ramracheya, Reshma; Rorsman, Nils J. G.; Leiss, Veronika; et al. "Na+current properties in islet a- and ß-cells reflect cell-specific Scn3a and Scn9a expression". The Journal of Physiology 592 21 (2014): 4677-4696. http://dx.doi.org/10.1113/jphysiol.2014.274209.
    10.1113/jphysiol.2014.274209
  30. Brereton, Melissa F.; Iberl, Michaela; Shimomura, Kenju; Zhang, Quan; Adriaenssens, Alice E.; Proks, Peter; Spiliotis, Ioannis I.; et al. "Reversible changes in pancreatic islet structure and function produced by elevated blood glucose". Nature Communications 5 1 (2014): http://dx.doi.org/10.1038/ncomms5639.
    10.1038/ncomms5639
  31. Rorsman, Patrik; Ramracheya, Reshma; Rorsman, Nils J. G.; Zhang, Quan. "ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion". Diabetologia 57 9 (2014): 1749-1761. http://dx.doi.org/10.1007/s00125-014-3279-8.
    10.1007/s00125-014-3279-8
  32. Latreille, Mathieu; Hausser, Jean; Stützer, Ina; Zhang, Quan; Hastoy, Benoit; Gargani, Sofia; Kerr-Conte, Julie; et al. "MicroRNA-7a regulates pancreatic ß cell function". Journal of Clinical Investigation 124 6 (2014): 2722-2735. http://dx.doi.org/10.1172/jci73066.
    10.1172/jci73066
  33. Zhang, Quan; Ramracheya, Reshma; Lahmann, Carolina; Tarasov, Andrei; Bengtsson, Martin; Braha, Orit; Braun, Matthias; et al. "Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes". Cell Metabolism 18 6 (2013): 871-882. http://dx.doi.org/10.1016/j.cmet.2013.10.014.
    10.1016/j.cmet.2013.10.014
  34. Rorsman, Patrik; Braun, Matthias; Zhang, Quan. "Regulation of calcium in pancreatic a- and ß-cells in health and disease". Cell Calcium 51 3-4 (2012): 300-308. http://dx.doi.org/10.1016/j.ceca.2011.11.006.
    10.1016/j.ceca.2011.11.006
  35. Hoppa, M. B.; Jones, E.; Karanauskaite, J.; Ramracheya, R.; Braun, M.; Collins, S. C.; Zhang, Q.; et al. "Multivesicular exocytosis in rat pancreatic beta cells". Diabetologia 55 4 (2011): 1001-1012. http://dx.doi.org/10.1007/s00125-011-2400-5.
    10.1007/s00125-011-2400-5
  36. Rorsman, Patrik; Eliasson, Lena; Kanno, Takahiro; Zhang, Quan; Gopel, Sven. "Electrophysiology of pancreatic ß-cells in intact mouse islets of Langerhans". Progress in Biophysics and Molecular Biology 107 2 (2011): 224-235. http://dx.doi.org/10.1016/j.pbiomolbio.2011.06.009.
    10.1016/j.pbiomolbio.2011.06.009
  37. Walker, J. N.; Ramracheya, R.; Zhang, Q.; Johnson, P. R. V.; Braun, M.; Rorsman, P.. "Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?". Diabetes, Obesity and Metabolism 13 (2011): 95-105. http://dx.doi.org/10.1111/j.1463-1326.2011.01450.x.
    10.1111/j.1463-1326.2011.01450.x
  38. Ramracheya, R.; Ward, C.; Shigeto, M.; Walker, J. N.; Amisten, S.; Zhang, Q.; Johnson, P. R.; Rorsman, P.; Braun, M.. "Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in alpha-Cells Inhibits Glucagon Secretion From Human Islets". Diabetes 59 9 (2010): 2198-2208. http://dx.doi.org/10.2337/db09-1505.
    10.2337/db09-1505
  39. Zhang, Quan; De Marinis, Yang Z.; Salehi, Albert; Ward, Caroline E.; Abdulkader, Fernando; Bengtsson, Martin; Braha, Orit; et al. "GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis". Cell Metabolism 11 6 (2010): 543-553. http://dx.doi.org/10.1016/j.cmet.2010.04.007.
    10.1016/j.cmet.2010.04.007
  40. Collins, S. C.; Hoppa, M. B.; Walker, J. N.; Amisten, S.; Abdulkader, F.; Bengtsson, M.; Fearnside, J.; et al. "Progression of Diet-Induced Diabetes in C57BL6J Mice Involves Functional Dissociation of Ca2+ Channels From Secretory Vesicles". Diabetes 59 5 (2010): 1192-1201. http://dx.doi.org/10.2337/db09-0791.
    10.2337/db09-0791
  41. Hoppa, Michael B.; Collins, Stephan; Ramracheya, Reshma; Hodson, Leanne; Amisten, Stefan; Zhang, Quan; Johnson, Paul; et al. "Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca2+ Channels from Secretory Granules". Cell Metabolism 10 6 (2009): 455-465. http://dx.doi.org/10.1016/j.cmet.2009.09.011.
    10.1016/j.cmet.2009.09.011
  42. Braun, M.; Ramracheya, R.; Amisten, S.; Bengtsson, M.; Moritoh, Y.; Zhang, Q.; Johnson, P. R.; Rorsman, P.. "Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells". Diabetologia 52 8 (2009): 1566-1578. http://dx.doi.org/10.1007/s00125-009-1382-z.
    10.1007/s00125-009-1382-z
  43. Gustavsson, Natalia; Wei, Shun-Hui; Hoang, Dong Nhut; Lao, Ye; Zhang, Quan; Radda, George K.; Rorsman, Patrik; Südhof, Thomas C.; Han, Weiping. "Synaptotagmin-7 is a principal Ca2+sensor for Ca2+-induced glucagon exocytosis in pancreas". The Journal of Physiology 587 6 (2009): 1169-1178. http://dx.doi.org/10.1113/jphysiol.2008.168005.
    10.1113/jphysiol.2008.168005
  44. Zhang, Quan; Galvanovskis, Juris; Abdulkader, Fernando; Partridge, Christopher J; Göpel, Sven O; Eliasson, Lena; Rorsman, Patrik. "Cell coupling in mouse pancreatic ß-cells measured in intact islets of Langerhans". Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 366 1880 (2008): 3503-3523. http://dx.doi.org/10.1098/rsta.2008.0110.
    10.1098/rsta.2008.0110
  45. Braun, M.; Ramracheya, R.; Bengtsson, M.; Zhang, Q.; Karanauskaite, J.; Partridge, C.; Johnson, P. R.; Rorsman, P.. "Voltage-Gated Ion Channels in Human Pancreatic  -Cells: Electrophysiological Characterization and Role in Insulin Secretion". Diabetes 57 6 (2008): 1618-1628. http://dx.doi.org/10.2337/db07-0991.
    10.2337/db07-0991
  46. Zhang, Quan; Bengtsson, Martin; Partridge, Chris; Salehi, Albert; Braun, Matthias; Cox, Roger; Eliasson, Lena; et al. "R-type Ca2+-channel-evoked CICR regulates glucose-induced somatostatin secretion". Nature Cell Biology 9 4 (2007): 453-460. http://dx.doi.org/10.1038/ncb1563.
    10.1038/ncb1563
  47. Göpel, Sven; Zhang, Quan; Eliasson, Lena; Ma, Xiao-Song; Galvanovskis, Juris; Kanno, Takahiro; Salehi, Albert; Rorsman, Patrik. "Capacitance measurements of exocytosis in mouse pancreatic a-, ß- and d-cells within intact islets of Langerhans". The Journal of Physiology 556 3 (2004): 711-726. http://dx.doi.org/10.1113/jphysiol.2003.059675.
    10.1113/jphysiol.2003.059675

Other

Other output
  1. Temporal Metabolic Characteristics and Transcriptomic Landscape of Islets and Liver Reveal Dynamic Pathophysiology and Interorgan Crosstalk in High-fat Diet-induced Diabetes. 2020. Gao, R.; Fu, Q.; Jiang, H.-M.; Shen, M.; Zhao, R.-L.; Qian, Y.; He, Y.-Q.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85102909397&partnerID=MN8TOARS.
    10.1101/2020.08.21.195453
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/09 Role of delta cells in islet regulation 58th European Association for the Study of Diabetes Annual Meeting
European Association for the Study of Diabetes (Stockholm, Sweden)
2021/06 Alpha-delta cell interaction in pancreatic islets and its metabolic memory 55th European Society for Clinical Investigation Annual Scientific Meeting
European Society for Clinical Investigation
2020/09 delta cell regulatory mechanism - feedback system from the pancreatic beta cells Islet and Metabolism Forum
Nanjing Medical University (China)
2020/06/13 the Elusive Delta Cell—Mechanisms Underlying Somatostatin Release American Diabetes Association Annual Meeting
American Diabetes Association (chicago, United States)
2019/09/23 cAMP dependent regulation of somatostatin secretion from pancreatic delta cells 2019 Islet and Metabolism Forum
Nanjing Medical University (Nanjing , China)
2019/02/20 Intracellular Ca2+ dynamics in non-beta cells Metabolism symposium
Shandong University (Jinan, China)
2018/08/15 Regulation of somatostatin secretion – cAMP dependent pathways Shandong University Medical School seminar series
Shandong University (Jinan, China)
2017/08/18 Electrical activity and Ca2+ oscillations of non-beta cells in pancreatic islet Gothenburg University Department of Physiology - department talk
Department of Physiology, Gothenburg University (Gothenburg, Sweden)
2017/03/16 ion channels in pancreatic islet alpha cells and regulation of glucagon secretion The Annual Meeting of Japanese Pharmacological Society 2017
Japanese Pharmacological Society (Nagasaki , Japan)
2016/08/18 Glucagon, the alpha-cell and intra-islet paracrine relationships 21st EASD-HAGEDORN OXFORD workshop
European Association for the Study of Diabetes (Oxford, United Kingdom)
2016/02/09 Electrophysiology and Ca2+ dynamics of non-beta cells in pancreatic islets OCDEM Islet Research Day 2016 - Annual Matthias Braun Lecture
Oxford Centre for Diabetes Endocrinology and Metabolism (Oxford, United Kingdom)
2015/12/02 Glucose regulation of glucagon secretion from pancreatic alpha cells Diabetes UK lecture
Diabetes UK (London, United Kingdom)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020/02/01 - 2024/02/01 alpha cell pathophysiology
Co-supervisor
Göteborgs universitet Institutionen for neurovetenskap och fysiologi, Sweden
2022/01/01 - 2024/01/01 Investigation of the role of intracellular Ca2+ store (endoplasmic reticulum) in alpha cell glucose sensing and glucagon secretion
Co-supervisor
Sichuan University West China Hospital, China

University of Oxford Radcliffe Department of Medicine, United Kingdom
2019/07/01 - 2021/05/30 Glucagon-somatostatin-glucagon interaction within the pancreatic islets
Co-supervisor
 Physiology (PhD)
Oxford Centre for Diabetes Endocrinology and Metabolism, United Kingdom

Nanjing Medical University, China
2014/09/01 - 2018/05/22 Properties of voltage-gated Na+ channels in pancreatic beta-cells
Co-supervisor
 Physiology (PhD)
University of Oxford Radcliffe Department of Medicine, United Kingdom

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016 - Current Oxford Centre for Diabetes, Endocrinology and Metabolism Weekly Scientific Seminars (2016)
Seminar (Co-organisor)
 Oxford Centre for Diabetes Endocrinology and Metabolism, United Kingdom
2023 - 2023 CIBB annual meeting (2023 - 2023)
Symposium (Member of the Organising Committee)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/06 - 2019/06 BRC Diabetes&Metabolism - PPI MEETING #6 Interaction with patients group
Meeting
 BRC Diabetes&Metabolism - PPI MEETING #6
NIHR Oxford Biomedical Research Centre, United Kingdom

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2023 - 2023 Reviewer for grant application Stanford Diabetes Research Center, United States
2021/06 - 2021/09 Evaluation for Medical Research Council (UKRI MRC) Clinical Research Training Fellowship (CRTF) Pre Doc April 2021
Evaluator
 Medical Research Council Swindon, United Kingdom

UK Research and Innovation, United Kingdom
2020/12 - 2021/03 Evaluation for Medical Research Council (UKRI MRC) Clinical Research Training Fellowship (CRTF) Pre Doc Jan 2021
Evaluator
 Medical Research Council Swindon, United Kingdom

UK Research and Innovation, United Kingdom
2021/02 - 2021/02 Evaluation for postgraduate student admission for the University of Oxford
Evaluator
 University of Oxford Radcliffe Department of Medicine, United Kingdom
2020/04 - 2020/04 Reviewer for research project grants (responsive mode)
Evaluator
 Biotechnology and Biological Sciences Research Council

Journal scientific committee

Journal title (ISSN) Publisher
2024 - Current Diabetes
2020/05 - Current Chronic Diseases and Translational Medicine (2095-882X) KeAi Publishing Communications
2020 - Current Biology (2079-7737) MDPI

Mentoring / Tutoring

Topic Student name
2020/05/03 - 2020/08/30 the role of Hexokinase I in glucagon secretion Sasha Webber
2019/03/01 - 2019/03/11 Insulin resistance and how might it cause diseases Lee Quill
2014/09/01 - 2015/03/01 An intracellular factor that locks the inactivation of Nav 1.7 channel – Nav channels in pancreatic islet cells Lukas Groschner

Other jury / evaluation

Activity description Institution / Organization
2019/10 - 2019/10 Examiner for Confirmation of D.Phil Status (Ms. Clair Duff ) University of Oxford Radcliffe Department of Medicine, United Kingdom
2018/09 - 2018/09 Examiner for Confirmation of D.Phil Status: Ms Katia Mattis University of Oxford Radcliffe Department of Medicine, United Kingdom
2018/01 - 2018/01 Examiner for Transfer of D.Phil Status: Ms. Clair Duff University of Oxford Radcliffe Department of Medicine, United Kingdom
2017/09 - 2017/09 Examiner for Confirmation of D.Phil Status: Dr. Hakan Cetin University of Oxford Nuffield Department of Clinical Neurosciences, United Kingdom
Distinctions

Award

2021 Outstanding Editorial Board Member
Chronic Diseases and Translational Medicine, China
2009 Best Pre-clinical Dissertation in Diabetology of 2008 in Sweden
Svensk Förening för Diabetologi, Sweden
2007 Chinese Government Award for Outstanding Self-financed Student Abroad
Ministry of Education, China