Ana Preto (C81F-9F8C-1790)

Curriculum Vitae

Ana Preto

Ana Preto (APreto) is Assistant Professor at the Department of Biology, senior researcher at CBMA, University of Minho (UMinho) since 2007. She graduated in Pharmaceutical Sciences from the Faculty of Pharmacy in 1998 and completed her PhD in Human Biology by the Faculty of Medicine in 2004, both at the University of Porto. APreto was a PhD student of the PhD Program GABBA and performed the PhD in IPATIMUP in collaboration with the Department of Pathology, University of Wales College of Medicine, Cardiff, Wales, UK (2000/2004). From 2004 to 2007 had a Post-Doc position at IPATIMUP. She was the former Director of the MSc in Molecular Genetics and of the BSc in Biochemistry at the UMinho. Since 2009 at CBMA, APreto has been interested in understand how environmental exposome, namelly diet-derived microbiota metabolites have influence in the biology of cells, using "normal" colon, the yeast Saccharomyces cerevisiae and colorectal cancer cells as models. She has been focus in unravelling the molecular and cellular mechanism of response to short chain fatty acids (SCFA) namely acetate, propionate, butyrate and other metabolites produced by the diet-derived microbiota. Ana Preto has also been focus in understanding the role of KRAS mutations signalling pathways in autophagy, apoptosis and tumour microenvironment regulation and its impact in colorectal cancer (CRC) survival. AP as pharmacist has been interested in the identification of new molecular targets and mechanisms, which could inspire other groups, with whom she collaborates, to the development of new bioinspired compounds/systems. In this context, APreto group and collaborators recently established the "proof of concept" for PMC79 a promising patented Ru-compound specific for KRAS hotspot mutations opening a new avenue in the therapy of resistant cancer harbouring KRAS mutations (international patent PCT WO/2023/161781A1). APreto emerging interest is in environment risk assessment, namelly on understanding how the environmental exposome and biological stressors derived from aquatic and agrifood sources might impact on the microbiota and on the biology of cells. APreto has served as Reviewer at 35 peer-reviewed journals and was evaluator for: research PhD grants at the "Fonds National de la Recherche (FNR), Luxembourg; research projects from the Gabinete de Apoio à Investigação (GAI), from the Faculty of Medicine from the University of Coimbra and research projects from the "Institut National du Cancer" (INCa), France. APreto has been editor of several research journals, namely Guest Associate Editor at Frontiers in Nutrition, Frontiers in Oncology and Cells. APreto has been involved in the organising committees and chair of both National and International meetings. Granted 7 prizes and 4 grants; supervised 2 post-doctoral fellows and 42 post-graduate students including 31 Master students and 11 PhD students (2 ongoing). APreto participated as team member, PI or Co-PI in 17 research projects: 14 National, 2 European (1 FP7 and 1 Marie Curie) and 1 USA (financed by KoDiscovery company) reflecting her multidisciplinary scientific expertise. . Co-authored 3 Patents. APreto has 85 Scientific Publications (68 Papers in scientific journals with peer review indexed in ISI; 17 Abstracts published in proceedings of scientific meetings), 1 book chapter, and 149 Scientific Communications (40 Oral communications and 109 Posters).

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Identification

Personal identification

Full name: Ana Preto

Citation names

Preto, Ana
Preto A
Ana Preto

Author identifiers

Ciência ID: C81F-9F8C-1790
ORCID iD: 0000-0002-7302-0630
Google Scholar ID: https://scholar.google.pt/citations?user=9AEIAW0AAAAJ&hl=en
Researcher Id: H-8112-2012
Scopus Author Id: 6602508305

Email addresses

apreto@bio.uminho.pt (Professional)

Telephones

Fax

253678980 (Professional)

Telephone

253601524 (Professional)

Addresses

Departamento de Biologia, Escola de Ciências, Universidade do Minho. Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Professional)

Websites

https://cbma.uminho.pt/people-detail/?userid=17 (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Cell Biology

Languages

Language	Speaking	Reading	Writing	Listening
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
French	Advanced (C1)	Advanced (C1)	Intermediate (B1)	Advanced (C1)
Spanish; Castilian	Advanced (C1)	Advanced (C1)	Intermediate (B1)	Advanced (C1)
Portuguese	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2000/07 - 2004/01 Concluded	PhD in Human Biology (Doutoramento) Major in GABBA Universidade do Porto Faculdade de Medicina, Portugal "Identification of potential mechanisms of tolerance to wild-type p53 in human carcinogenesis using thyroid neoplasia as a prototype" (THESIS/DISSERTATION)	Maximum classification (unanimously)
1992/09 - 1998/07 Concluded	Bachelor degree in Pharmaceutical Sciences (Licenciatura) Universidade do Porto Faculdade de Farmácia, Portugal	15/20 values

Affiliation

Science

	Category Host institution	Employer
2007 - Current	Visiting Researcher (Research)	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2007 - Current	Principal Investigator (Research)	Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
	Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2004 - 2007	Postdoc (Research)	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2007 - Current	Assistant Professor (University Teacher)	Universidade do Minho Departamento de Biologia, Portugal
	Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2018/04/02 - 2018/04/23	Visiting Professor (University Teacher)	Brunel University London - Institute of Environment, Health and Societies, College of Health and Life Sciences, United Kingdom
	Brunel University London - Institute of Environment, Health and Societies, College of Health and Life Sciences, United Kingdom
2007 - 2009	Invited Assistant Professor (University Teacher)	Universidade do Minho Departamento de Biologia, Portugal
	Universidade do Minho Departamento de Biologia, Portugal
2004 - 2007	Invited Assistant Professor (University Teacher)	Instituto Superior de Saúde, Portugal
	Instituto Superior de Saúde, Portugal

Positions / Appointments

	Category Host institution	Employer
2021 - Current	Member of the Scientific Council of ECUM	Universidade do Minho, Portugal
	Universidade do Minho Escola de Ciências, Portugal
2021 - 2023	Director of the Bachelor in Biochemistry	Universidade do Minho, Portugal
	Universidade do Minho Departamento de Biologia, Portugal
2021 - 2023	Member of the Pedagogical Council of ECUM	Universidade do Minho Escola de Ciências, Portugal
	Universidade do Minho Escola de Ciências, Portugal
2018 - 2023	Member of the Management Team of Associação Portuguesa de Investigação em Cancro (ASPIC)	Associação Portuguesa de Investigação em Cancro (ASPIC), Portugal
	Associação Portuguesa de Investigação em Cancro (ASPIC), Portugal
2013 - 2020	Responsible Pharmaceutical (professional license nº 10931) at INFARMED for lmport, management and conservation of Narcotics / Psychotropic Substances	Ordem dos Farmaceuticos, Portugal
	Ordem dos Farmaceuticos, Portugal
2015 - 2017	Member of the Committee of the Master's in Molecular Genetics	Universidade do Minho, Portugal
	Universidade do Minho Departamento de Biologia, Portugal
2013 - 2016	Member of the Scientific Committee of the Doctoral Program in Molecular and Environmental Biology	Universidade do Minho, Portugal
	Universidade do Minho Departamento de Biologia, Portugal
2013 - 2015	Director of the Master's Degree in Molecular Genetics	Universidade do Minho, Portugal
	Universidade do Minho Departamento de Biologia, Portugal
2013 - 2015	Member of the ECUM Pedagogical Council	Universidade do Minho, Portugal
	Universidade do Minho Escola de Ciências, Portugal
2011 - 2013	Member of the Applied Biology Course Committee, coordinator of the 1st academic year	Universidade do Minho, Portugal
	Universidade do Minho Departamento de Biologia, Portugal
2010 - 2013	Coordinator of the CBMA research area: Molecular targets for human diseases	Universidade do Minho, Portugal
	Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2010 - 2012	Member of the Quality Committee of the Scientific Council of the Department of Biology	Universidade do Minho, Portugal
	Universidade do Minho Departamento de Biologia, Portugal

Projects

Grant

	Designation	Funders
2018 - 2018	Sabbatical grant under the Program IACOBUS IACOBUS Sabbatical grant
2004 - 2007	Potential mechanisms of tolerance to wild-type p53 in human tumours using differentiated thyroid carcinoma as a prototype SFRH/BPD/14882/2003 Post-doc Fellow Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
1999 - 2003	Identification of potential mechanisms of tolerance to wild-type p53 in human carcinogenesis using thyroid neoplasia as a prototype PRAXIS XXI/BD/21795/99 PhD Student Fellow Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
1998 - 1999	Identification of biological markers of diagnosis and prognosis in thyroid carcinomas, using differential display technique PRAXIS XXI/BIC/17133/98 Scientific Initiation Fellow Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
1998 - 1999	Identification of biological markers of diagnosis and prognosis in thyroid carcinomas, using differential display technique PRAXIS XXI/BIC/17133/98	Fundação para a Ciência e a Tecnologia

Contract

	Designation	Funders
2022 - Current	Programa Pessoa 2022-2023 Agreement between Portugal and France- 2021.09253.CBM- "BAXREG: In vivo and in vitro approaches towards the elucidation of Bax regulation mechanisms by N-terminal acetylation and by interaction with the KRAS oncogene" 2021.09253.CBM Researcher Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019 - Current	CBMA's Strategic Project as a Center of Excellence UID/BIA/04050/2019 Integrated membership Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018 - 2021	Lead4Target - Fighting metastatic cancers: prime time for ruthenium PTDC/QUI-QIN/28662/2017 Principal investigator Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018 - 2021	The other faces of telomerase: looking beyond tumor immortalization PTDC/MED-ONC/31438/2017 Researcher Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016 - 2019	EcoAgriFood - Innovative green products and processes to promote Agri-Food BioEconomy NORTE-45-2015-02 Researcher Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal	União Europeia - Portugal 2020 - Norte 2020 Concluded
2015 - 2017	CBMA's strategic project as a Center of Excellence UID/BIA/04050/2013 Integrated membership Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013 - 2016	Phosphobax - Phosphoregulation of Bax-dependent cell death FCT-ANR/BEX-BCM/0175/2012 Researcher Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013 - 2016	GLYCOPHARM - The Sugar Code: from bio(chemical) concept to clinics FP7-PEOPLE-2012-ITN Researcher Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal	Marie Curie Concluded
2009 - 2013	NANOFOL - Folate-based nanobiodevices for integrated diagnosis/therapy targeting chronic inflammatory diseases FP7 NMP-2008-4.0-1 Researcher Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal	União Europeia Concluded
2009/01/01 - 2012/06/30	Elucidation of ceramide-induced apoptosis: modulation of Protein Kinase C isoforms PTDC/BIA-BCM/69448/2006 Researcher Universidade do Minho Departamento de Biologia, Portugal Universidade do Minho, Portugal Universidade do Porto Faculdade de Farmácia, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005 - 2008	BRAF and KRAS mutations in mismatch repair deficiency colon cancer. New prognostic and therapeutic tool? POCTI/SAU-OBS/56921/2004 Researcher Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia
2005 - 2008	Oncogenic role of BRAF activation in thyroid carcinogenesis. Provided by PTCRIS: 56175 POCTI/SAU-OBS/56175/2004 Researcher Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005 - 2008	In mismatch repair deficiency colorectal cancer are BRAF and KRAS new prognostic and therapeutic tools? Provided by PTCRIS: 56921 Researcher Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005 - 2008	In vitro studies of compounds with putative anti-oxidant activity, obtained from medicinal plants traditionally used in Portugal Anti-oxidant - UNICER Researcher Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	UNICER Concluded
2003/07/01 - 2008	Potential mechanisms of tolerance to wild-type p53 in human tumours using differentiated thyroid carcinoma as a prototype. FCT/POCI/41084/PT Researcher Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia
2004 - 2007	Role of raft domains in the modulation/alteration of the transducing pathways in normal thyroid and in papillary thyroid carcinoma PTCRIS: 48171 Researcher Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2006 - 2006	Biological role of BRAF activation in colon carcinogenesis. STI-571/Gleevec as a therapeutic agent? STI-571/Gleevec Principal investigator Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Novartis AG Concluded
2004 - 2006	Biological role of BRAF oncogene activation in human carcinogenesis. Use of BAY 43-9006 as a BRAF inhibitor agent? BAY 43-9006 Principal investigator Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Bayer Portugal SA Concluded
1995 - 1998	Identification of biological markers of diagnosis and prognosis in thyroid carcinomas, using differential display technique PRAXIS XXI/2/2.1/SAU/1187/95 Researcher Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia

Outputs

Publications

Book chapter	Cazzanelli, Giulia; Moreira, Tiago; Ferro, Suellen; Azevedo-Silva, João; Nogueira, Eugénia; Preto, Ana. "Colorectal Cancer Therapeutic Approaches: From Classical Drugs to New Nanoparticles". In Frontiers in Anti-Cancer Drug Discovery, 93-173. BENTHAM SCIENCE PUBLISHERS, 2016. 10.2174/9781681082516116070004
Conference abstract	Ferreira, João Carlos; Gonçalves, Maria Sameiro; Preto, Ana; Sousa, Maria. "The potential of novel benzo[a]phenoxazine derivatives for colorectal cancer treatment". 2021. 10.3390/ecmc2021-11522 Preto, Ana; Brás, Ana Rita; Fernandes, Pedro; Moreira, Tiago; Valente, Andreia. "New ruthenium-cyclopentadienyl agents as a new strategy to fight colorectal cancer". 2021. 10.3390/ecmc2021-11457 Matos, A; Marques, F; Francisco, R; Moreira, T; Preto, A; Garcia, MH; Valente, A. "Unraveling the mode of action of new promising polymer-ruthenium conjugates". Paper presented in Ultrastruct Pathol, 2017. Valente, A; Moreira, T; Brás, AR; Preto, A; Garcia, MH. "Cancer targeted therapy: the next generation of metallodrugs". 2017. Azevedo-Silva, João; Queirós, Odília; Ko, YH; Pedersen, Peter; Preto, Ana; Casal, Margarida. "Characterization of 3-bromopyruvate uptake in breast cancer cells". Paper presented in 4th Annual Meeting of the International Society of Proton Dynamics in Cancer, 2014. Amorim, Ricardo; Martins, Sandra; Longatto-Filho, Adhemar; Preto, Ana; Baltazar, Fátima. "Exploiting monocarboxylate transporters as newmolecular targets for colorectal carcinomatherapy. ets for colorectal carcinoma therapy". Paper presented in BMC Proceedings 2013, 2013. Nogueira, Eugénia; Preto, Ana; Cavaco-Paulo, Artur. "Liposomal formulations for specific drug delivery". 2012. Pacheco, A; Queirós, O; Preto, A; Pinheiro, C; Azevedo-Silva, J; Moreira, R; Pedro, M; Baltazar, F; Casal, M. "3-bromopyruvate cytotoxic effect in breast cancer cells is dependent of monocarboxylate transporters (MCT) expression and is enhanced by butyrate". Paper presented in Exp Clin Endocrinol Diabetes, 2012. Published Amorim, R; Vilaça, N; Fonseca, AM; Neves, IC; Preto, A; Baltazar, F. "Enhancing 5-FU Activity in Colorectal Carcinoma-derived Cell Lines – Combination With Monocarboxylate Transporter Inhibitors and Encapsulation into Zeolites". Paper presented in 22nd Biennial Congress of the European Association for Cancer Research, 2012. Published Sousa, MJ; Azevedo, F; Pedras, A; Marques, C; Coutinho, OP; Preto, A; Gerós, H; Chaves, SR; Côrte-Real, M. "Vacuole-mitochondrial cross-talk during apoptosis in yeast: a model for understanding lysosome-mitochondria-mediated apoptosis in mammals". Paper presented in BIOCHEMICAL SOCIETY TRANSACTIONS, 2011. Published Ferreira, M; Araújo, R; Preto, A; Gomes, AC; Cavaco-Paulo, A. "Capillary treatments using siRNA oligonucleotides- a new gene therapy tool?". Paper presented in 14th Annual Meeting, EHRS, European Hair Research Society, Graz, 2009. Published Xavier, CPR; Lima, CF; Preto, A; Seruca, R; Fernandes-Ferreira, M; Pereira-Wilson, C. "Quercetin, Luteolin and ursolic acid are potent inhibitors of proliferation in colorectal carcinoma cells: new therapeutic tools?". Paper presented in European Journal of Cancer Supplements, 2008. Published Preto, A; Rebocho, AP; Meireles, AM; Seruca, R; Soares, P; Sobrinho-Simões, M. "Novas terapêuticas no carcinoma da tireóide: efeito biológico da inibição farmacológica de cinases em linhas celulares do carcinoma da tiróide". Paper presented in Tumores endócrinos-7º simpósio nacional, Porto, 2007. Published Reis-Filho, J.S.; Martins, A; Preto, A; Soares, P; Schmitt, FC. "Distribution of p63, Cytokeratin 5/6 and Cytokeratin 14 in 51 Normal and 450 Neoplastic Human Tissue Samples Using TARP-4 Multi-Tumor Tissue Microarray". Paper presented in 92th Annual Meeting of the United States and Canadian Academy of Pathology, Washington DC, 2003. Published Preto, A; Haughton, M; Kipling, D; Soares, P; Wynford-Thomas, D; Jones, CJ. "P53 mediated growth arrest in response to telomere erosion is retained in a subset of human cancer cell lines". Paper presented in 1º Congresso da Sociedade Portuguesa de Ciências Farmacêuticas, Lisboa, 2003. Published Reis-Filho, JS; Preto, A; Ricardo, S; Soares, P. "p63 expression in papillary and anaplastic carcinomas of the thyroid gland". Paper presented in p63 expression in papillary and anaplastic carcinomas of the thyroid gland”. XXIVth International Congress of the International Academy of Pathology, Amsterdão, 2002. Published Reis-Filho, JS; Preto, A; Soares, P; Ricardo, S; Cameselle-Teijeiro, J; Sobrinho-Simões, M. "p63 in solid cell nests: further evidence for a stem cell origin". Paper presented in p63 in Solid cell nests:further evidence for a stem cell origin”. XXIVth International Congress of the International Academy of Pathology, Amsterdão, 2002. Published
Conference paper	Casanova, Marta; Preto, Ana; Rodrigues, L. R.. "Improved production of acetate and propionate by Propionibacterium freudenreichii". 2014. Nogueira, Eugénia Sofia Costa; Preto, Ana; Cavaco-Paulo, Artur. "Liposomal formulations for specific drug delivery". 2013. Amorim, Ricardo; Vilaça, Natália; Fonseca, António Manuel; Neves, Isabel C.; Preto, Ana; Baltazar, Fátima. "Enhancing 5-FU activity in colorectal carcinoma-derived cell lines: combination with monocarboxylate transporter inhibitors and encapsulation into zeolites". 2012. Amorim, Ricardo; Martins, Sandra; Pereira, Helena Paula Fernandes; Pinheiro, Céline; Reis, R. L.; Longatto Filho, Adhemar; Preto, Ana; Baltazar, Fátima. "Monocarboxylate transporters: new molecular targets for colorectal carcinoma". 2011. Pires, S.; Silva, E.; Queiroz, Maria João R. P.; Preto, Ana; Coutinho, O. P.. "New synthetic raloxifen-like di(hetero)arylamines induce apoptosis and inhibit the estrogen receptor in breast cancer cells". 2011. Chaves, S. R.; Coutinho, Clara Pereira; Marques, Carolina; Rodrigues, Andreia; Salin, Bénédict; Alves, Sara Cristina Sequeira; Silva, Rui; et al. "What yeast can tell us about how cells commit suicide?". 2011. Chaves, S. R.; Coutinho, Clara Pereira; Marques, Carolina; Rodrigues, Andreia; Salin, Bénédict; Alves, Sara Cristina Sequeira; Silva, Rui; et al. "Vacuole-mitochondrial crosstalk during apoptosis induced by acetic acid in yeast". 2011.
Conference poster	Brás, AR.; Fernandes, P.; Moreira, T.; Valente, A.; Preto, A.. Corresponding author: Preto, A.. "Ruthenium-based anticancer agents: new therapeutic approach against colorectal cancer.". Paper presented in II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer, 2021. Pereira, F.; Reis, CA.; Oliveira, MJ.; Preto, A.. Corresponding author: Preto, A.. "Dissecting the impact of KRAS/Galectin-3 complex in colorectal cancer.". Paper presented in 2021 II ASPIC-ASEICA International Meeting: Current Trends of Precision Medicine in Cancer, 2021. Ferreira, JC.; Gonçalves, MT.; Preto, A.; Sousa, MJ.. "The anticancer effect of a novel Benzo[a]phenoxazine derivative targeting lysosomes in colorectal cancer cells". Paper presented in II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer, 2021. Ferreira, A.; Côrte-Real, M.; Preto, A.; Sousa, MJ.. "Oncogenic KRAS mutations may modulate the pro-apoptotic protein BAX activity". Paper presented in II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer, 2021. Gomes, S; Baltazar, F.; Silva, E.; Preto, A.. "Effect of diet microbiota-derived short-chain fatty acids in colorectal cancer cells". Paper presented in 2021 11th Probiotics, prebiotics & new foods, 2021. Pereira, F.; Moreira-Barbosa, C.; Matos, A.; Reis, CA.; Oliveira, MJ; Preto, A.. Corresponding author: Preto, A.. "Colorectal cancer cells-macrophages interplay: the role of KRAS and Galectin-3". Paper presented in 27th Porto Cancer Meeting: Stemness & Metastasis: Advances in Research and Clinical Translation, 2021. Brás, Ana Rita; Fernandes, Pedro; Moreira, Tiago; Valente, Andreia; Preto, Ana. "Ruthenium-based agents as promising metallodrugs to fight colorectal cancer". Paper presented in 6th International Electronic Conference on Medicinal Chemistry, 2020. Pereira, Flávia; Gomez-Lazaro, M; Reis, C A; Oliveira, Maria José; Preto, Ana. "Unravel the role of KRAS/galectin-3 loop in colorectal microenvironment". Paper presented in 3rd PhDay : Back to the Future, 2020. Pereira, Flávia Couto Brandão; Gomez-Lazaro, M; Reis, C A; Oliveira, Maria José; Preto, Ana. "Unravel the role of KRAS/galectin-3 loop in colorectal microenvironment". Paper presented in Cancer Biology: From Basic To Translational Research, 2020. Brás, Ana Rita; Fernandes, Pedro; Moreira, Tiago; Valente, Andreia; Preto, Ana. "Fighting colorectal cancer with ruthenium-based agents". Paper presented in CQE days, 2020. Gomes, Sara Daniela Coelho; Silva, Elizabete; Baltazar, Fátima; Preto, Ana. "The role of microbiota-derived short chain fatty acids in the modulation of colorectal cancer glycolytic metabolism and extracellular pH". Paper presented in EACR-AACR-ASPIC Conference: Tumor Microenvironment, 2020. Ferreira, Anabela; Côrte-Real, Manuela; Preto, Ana; Sousa, Maria João. "Unveil the role of KRAS mutations in glycolytic metabolism". Paper presented in EACR-AACR-ASPIC Conference: Tumor Microenvironment, 2020. Pereira, Flávia Couto Brandão; Borges, A; Cruz, T; Oliveira, Maria José; Preto, Ana. "The impact of KRAS/galectin-3 loop in colorectal tumor microenvironment". Paper presented in EACR-AACR-ASPIC Conference: Tumor Microenvironment, 2020. Ferreira Anabela, Fazenda Ângela, Alves Sara, Côrte-Real Manuela, Preto Ana, Sousa Maria João. "Reciprocal interaction between pro-apoptotic BAX and oncogenic KRAS mutants". Paper presented in 2019 Porto Cancer Meeting, 2019. J. C. Ferreira, A. Almeida, M.S.T. Gonçalves, A. Preto, M. J. Sousa. "The anticancer potential of novel Benzo[a]phenoxazines derivatives for colorectal cancer treatment". Paper presented in 26th Porto Cancer Meeting 2019 & Porto-Bordeaux Joint Meeting, 2019. S. Gomes, J. Macedo, M. Azevedo, S. Chaves, E. Silva, F. Baltazar, A. Preto. "Uncovering the role of acetate in the prevention of colorectal cancer induced by food contaminants". Paper presented in Porto Cancer Meeting, 2019. Brás Ana R. , Fernandes P., Valente A., Preto Ana. "Discovering the molecular targets of new ruthenium-based anticancer agents for colorectal cancer therapy". Paper presented in 26th Porto Cancer Meeting, 2019. Ferreira Anabela, Fazenda Ângela, Alves Sara, Côrte-Real Manuela, Preto Ana, Sousa Maria João. "Reciprocal interaction between pro-apoptotic BAX and oncogenic KRAS mutants". Paper presented in V PDBMA Symposium (PhD program on Molecular and Environmental Biology), 2019. J. C. Ferreira, A. Almeida, M.S.T. Gonçalves, A. Preto, M. J. Sousa. "The anticancer potential of novel Benzo[a]phenoxazines derivatives for colorectal cancer treatment". Paper presented in V Simpósio PDBMA, 2019. Fernandes Pedro, Brás Ana R, Valente Andreia, Preto Ana. "New ruthenium-biotinylated anticancer agent for colorectal cancer therapy". Paper presented in V PDBMA Symposium, 2019. M. Azevedo, J. Macedo, S. Gomes, F. Baltazar, E. Silva; Preto, Ana. "Acetate as a possible protective agent against food contaminants in human colon". Paper presented in V Simpósio PDBMA, 2019. Ferreira A, Fazenda A, Alves S, Côrte-Real M, Preto A, Sousa MJ. "Oncogenic KRAS mutations may modulate the activity of pro-apoptotic protein BAX at the mitochondria". Paper presented in ISCaM 2019 - 6th Annual Meeting, 2019. Ferreira João, Almeida Ana, Gonçalves S, Preto Ana, Sousa M J. "Benzo[a]phenoxazines derivatives as potential novel agents for colorectal cancer therapy". Paper presented in ISCaM 2019, 6th Annual meeting, 2019. Brás Ana R., Fernandes Pedro, Moreira Tiago, Valente Andreia, Preto Ana. "New ruthenium-based anticancer agents: uncovering the molecular targets towards colorectal cancer therapy". Paper presented in ISCaM 2019, 6th Annual meeting, 2019. F Pereira, G Cazzanelli, PD Carvalho, S Alves, AM Costa, M Gomez-Lazaro, CA Reis, MJ Oliveira, A Preto. "Dissecting the impact of KRAS/Galectin-3 complex at the colorectal tumor microenvironment". Paper presented in ISCaM 2019, 6th Annual meeting, 2019. F Pereira, G Cazzanelli, PD Carvalho, S Alves, AM Costa, M Gomez-Lazaro, CA Reis, MJ Oliveira, A Preto. "Unravel the role of KRAS/Galectin-3 loop in the crosstalk between colorectal cancer cells and tumor-associated macrophages". Paper presented in V Symposium of the Doctoral Program on Molecular and Environmental Biology, 2019. F Pereira, G Cazzanelli, PD Carvalho, S Alves, AM Costa, M Gomez-Lazaro, CA Reis, MJ Oliveira, A Preto. "Unravel the role of KRAS/Galectin-3 loop in the crosstalk between colorectal cancer cells and tumor-associated macrophages". Paper presented in 2th PhDay: PhD Countdown, A time for Science, 2019. S. Gomes, S. Granja, F. Baltazar, E. Silva, A. Preto. "Unveiling the role of microbiome-derived short chain fatty acids in colorectal cancer metabolism". Paper presented in 6th Annual ISCaM Meeting, 2019. Mendes Adriana, Chang Fung-Yi, Loureiro Inês, Preto Ana, Carvalho Ana. "Unveilling the role of actin regulation on KRAS-induced autophagy using C. elegans as an in vivo model". Paper presented in ASCB/EMBO 2019 meeting, 2019. Mendes Adriana, Chang Fung-Yi, Loureiro Inês, Preto Ana, Carvalho Ana. "Unveilling the role of actin regulation on KRAS-induced autophagy using C. elegans as an in vivo model". Paper presented in SPAOM 2019, 2019. Vieira Joana, Azevedo-Silva João, Preto Ana, Casal Margarida, Queirós Odília. "Monocarboxylate transporters expression is influenced by different extracellular conditions determining the effect of 3-bromopyruvate in colorectal cancer cells". Paper presented in Porto Cancer Meeting, 2018. Brás A R, Moreira T, Silva S, Garcia MH, Valente A, Preto A. "New ruthenium-based anticancer agents: a promising therapeutic approach to colorectal cancer". Paper presented in Porto Cancer Meeting, 2018. Gomes S, Granja S, Baltazar F, Preto A. "Uncovering the role of acetate in the crosstalk between monocarboxylate transporters and oncogene signalling pathways in colorectal cancer". Paper presented in ASPIC, 2018. Pereira F , Cazzanelli G , Carvalho PD , Alves S , Costa AM , Pinto ML , Gomez-Lazaro M , Oliveira MJ, Preto Ana. "Identification of a novel KRAS/Galectin-3/p16INK4a triple axis in colorectal cancer: therapeutic implications". Paper presented in ASPIC, 2018. Brás A R, Moreira T, Silva S, Garcia MH, Valente A, Preto A. "Unraveling the molecular targets of new ruthenium compounds towards colorectal cancer therapy". Paper presented in ASPIC, 2018. Gomes S, Granja S, Baltazar F, Preto A. "The role of acetate in oncogene signalling activation and metabolism in colorectal cancer". Paper presented in IV Simpósio PDBMA, 2018. Mendes Adriana, Chang Fung-Yi, Loureiro Inês, Preto Ana, Carvalho Ana. "Unveil the role of actin on KRAS induced autophagy in colorectal cancer, using Caenorhabditis elegans as an in vivo model". Paper presented in i3s Annual Meeting 2018, 2018. Gomes S, Granja S, Baltazar F, Preto A. "Characterization of the signaling pathways associated with the effect of acetate in colorectal cancer cells". Paper presented in ICVS open day, 2017. Pereira F, Cazzanelli G, Carvalho P, Alves S, Costa A M, Pinto M L, Gomez-Lazaro M, Oliveira M, Preto A. "Understanding the role of KRAS hotspot mutations in the regulation of the p16INK4a/KRAS/Galectin-3 axis in colorectal cancer". Paper presented in 6th I3S Annual Meeting, 2017. Azevedo-Silva J, Queirós O, Ribeiro A, Baltazar F, Ko Y H, Petersen P L, Preto A, Casal M. "The extracellular pH influences the cytotoxicity and transport of 3-Bromopyruvate in breast cancer cells". Paper presented in 2º Congresso Internacional da Associação Portuguesa de Investigação em Cancro (ASPIC), 2016. Oliveira CSF, Pereira H, Alves S, Castro L, Baltazar F, Chaves SR, Côrte-Real M, Preto A. "Cathepsin D-mediated degradation of damaged mitochondria rescues colorectal cancer cells from acetate-induced apoptosis". Paper presented in 2º Congresso Internacional da Associação Portuguesa de Investigação em Cancro (ASPIC), 2016. Moreira T, Sanches A, Pilon A, Francisco R, Ferreira A, Garcia M H, Preto A, Valente A. "Exploring the effect of multifunctional polymer-ruthenium conjugates: new promising anticancer agentes". Paper presented in 2º Congresso Internacional da Associação Portuguesa de Investigação em Cancro (ASPIC), 2016. Azevedo-Silva J, Queirós O, Ribeiro A, Baltazar F, Ko Y H, Petersen P L, Preto A, Casal M. "The extracellular pH influences the cytotoxicity and transport of 3-Bromopyruvate by monocarboxylate transporters in breast cancer cells". Paper presented in XI Jornadas Portuguesas de Genética, 2016. Matos A, Marques F, Francisco R, Moreira T, Preto A, Garcia MH, Valente A. "Unraveling the mode of action of new promising polymer-ruthenium conjugates". Paper presented in ULTRAPATH XVIII, 2016. Moreira T, Francisco R, Garcia M H, Valente A, Preto A. "Exploring multifunctional polymer-ruthenium conjugates as new promising anticancer agentes". Paper presented in Sociedade Portuguesa de Bioquimica, 2016. Cazzanelli G, Carvalho P, Cunha C, Rodrigues A J, Lucas C, Oliveira M J, Preto A. "Uncover The Role Of KRAS/Galectin-3/P16ink4a Axis Regulation In Colorectal Cancer". Paper presented in Sociedade Portuguesa de Bioquimica, 2016. Cazzanelli G, Carvalho P, Cunha C, Rodrigues A J, Lucas C, Oliveira M J, Preto A. "Understanding the role of oncogenic KRAS mutations in the regulation of mitochondria and Bax-mediated cell death". Paper presented in Sociedade Portuguesa de Bioquimica, 2016. Azevedo-Silva J, Queirós O, Ribeiro A, Baltazar F, Ko Y H, Petersen P L, Preto A, Casal M. "The cytotoxicity of 3-Bromopyruvate in breast cancer cells depends on extracellular pH". Paper presented in 10th European Biophysics Congress, 2015. Alves S, Castro L, Fernandes M S, Castro P, Priault M, Chaves S R, Moye M P. "Hotspot mutations in the KRAS oncogene function as positive regulators of autophagy in the colon". Paper presented in XXIII Porto Cancer Meeting, 2015. Ferro S, Pereira H, Alves S, Castro L, Baltazar F, Chaves S, Côrte-Real M, Preto A. "Cathepsin D is involved in the degradation of damaged mitochondria during acetate-induced apoptosis in colorectal cancer cells". Paper presented in XXIII Porto Cancer Meeting - Stem Cells and Cancer, 2015. Nogueira E, Cavaco-Paulo A, Preto A. "Folate-target liposomal nanoparticles for cancer therapy". Paper presented in XXIII Porto Cancer Meeting - Stem Cells and Cancer, 2015. Casanova M, Rodrigues L, Preto A. "Short chain fatty acids produced by Propionibacterium freudenreichii inhibit colorectal cancer cells survival". Paper presented in Porto Cancer Meeting - Stem Cells and Cancer, 2015. Nogueira S S, Brezesinski G, Gomes A C, Preto A, Oliveira M E. "Monoolein-based nanocarriers for siRNA delivery in colorectal cancer therapy". Paper presented in 6th Iberian Meeting on Colloids and Interfaces, 2015. Azevedo-Silva J, Baltazar F, Ko Y H, Petersen P L, Preto A, Casal M. "Silencing of Monocarboxylate transporters as a tool to study the role of 3-bromopyruvate in breast cancer". Paper presented in XXXIX Jornadas Portuguesas de Genética, 2015. Ferro S, Pereira H, Alves S, Castro L, Baltazar F, Chaves S, Preto A, Côrte-Real M. "Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria". Paper presented in XXXIX Jornadas Portuguesas de Genética, 2015. Casanova M, Rodrigues L, Preto A. "Propionibacterium freudenreichii short-chain fatty acids inhibit the proliferation of colorectal cancer cells". Paper presented in XXXIX Jornadas Portuguesas de Genética, 2015. Ferro S, Pereira H, Alves S, Castro L, Baltazar F, Chaves S, Preto A, Côrte-Real M. "Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria". Paper presented in IMYA 29, 2015. Alves S, Castro L, Fernandes M S, Francisco R, Castro P, Priault M, Chave S R. "Colon cancer-related mutant KRAS alleles function as positive regulators of autophagy". Paper presented in IMYA 29, 2015. Oliveira C S, Marques C, Alves S, Castro L, Pereira H, Chaves S R, Azevedo-Silva J, Casal M, Baltazar F. "Unravel the mechanisms of acetate induced apoptosis in colorectal cancer". Paper presented in PDBMA Symposium, 2015. Oliveira C S, Marques C, Alves S, Chaves S R, Côrte-Real M, Preto A. "Acetate induces lysosomal membrane permeabilization, cathepsin D release and impairs autophagy in colorectal carcinoma cells". Paper presented in 2nd EACR Special Conference on Cell Death in Cancer, 2014. Casanova M, Preto A, Rodrigues L. "Improved production of acetate and propionate by Propionibacterium freudenreichii". Paper presented in XVIII Congress of the Portuguese Biochemical Society (SPB), 2014. Oliveira C S, Pereira H, Alves S, Chaves S R, Preto A, Côrte-Real M. "Cathepsin D protects colorectal carcinoma cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria: a new function unveiled by the yeast vacuolar protease Pep4p". Paper presented in XVIII Congress of the Portuguese Biochemical Society (SPB), 2014. Amorim R, Martins S, Longatto-Filho A, Preto A, Baltazar F. "Exploiting monocarboxylate transporters as newmolecular targets for colorectal carcinomatherapy". Paper presented in BMC Proceedings 201, 2013. Castro L, Soares P, Preto A. "Study of the role of RAF-1 in MAPK signaling in thyroid cancer cells". Paper presented in Porto Cancer Meeting, 2013. Nogueira E, Preto A, Cavaco-Paulo A. "Characterization of a new peptide as membrane anchor for the incorporation of ligand targeting into liposomes". Paper presented in Self-Assembly of Biopolymers, 2013. Oliveira C S F, Marques C, Alves S, Chaves S R, Coutinho O P, Côrte-Real M, Preto A. "Involvement of lysosomal membrane permeabilization and cathepsin D release in colorectal carcinoma cells acetate-induced apoptosis". Paper presented in PDBMA symposium, I Jornadas do Programa Doutoral em Biologia Molecular e Ambiental, 2013. Pacheco A, Queirós O, Preto A, Pinheiro C, Azevedo-Silva J, Moreira R, Pedro M, Baltazar F, Casal M. "3-bromopyruvate cytotoxic effect in breast cancer cells is dependent of monocarboxylate transporters (MCT) expression and is enhanced by butyrate". 2012. Amorim R, Vilaca N, Fonseca A M, Neves I C, Preto A, Baltazar F. "Enhancing 5-FU Activity in Colorectal Carcinoma-derived Cell Lines – Combination With Monocarboxylate Transporter Inhibitors and Encapsulation into Zeolites". Paper presented in 22nd Biennial Congress of the European Association for Cancer Research, 2012. Amorim R, Vilaça N, Fonseca A M, Neves I C, Preto A, Baltazar F. "Enhancing 5-FU activity in colorectal carcinoma-derived cell lines: combination with monocarboxylate transporter inhibitors and encapsulation into zeolites". Paper presented in EACR, 2012. Pacheco A, Queirós O, Preto A, Pinheiro C, Azevedo-Silva J, Moreira R, Pedro M, Baltazar F, Casal M. "Butyric acid increases monocarboxylate transporters (MCT) expression and enhances the cytotoxicity of the anti-tumoral agent 3-bromopyruvate (3-BP) in breast cancer cells". Paper presented in Porto Cancer Meeting, 2012. Alves S, Chaves S R, Oliveira C, Seruca R, Corte-Real M, Sousa M J, Preto A. "The role of KRAS mutations in autophagy regulation in colorectal carcinoma". Paper presented in Porto Cancer Meeting, 2012. Marques C, Oliveira C F S, Alves S, Côrte-Real M, Coutinho O P, Preto A. "The role of lysosomal membrane permeabilization in acetate-induced apoptosis in colorectal carcinoma cells". Paper presented in Porto Cancer Meeting, 2012. Amorim R, Pereira H, Preto A, Baltazar F. "Combination of 5-FU with monocarboxylate transporters inhibitors as a new therapeutic approach in colorectal carcinoma". Paper presented in Porto Cancer Meeting, 2012. Matamá T, Araújo R, Preto A, Gomes A, Cavaco-Paulo A. "Tamoxifen speeds up melanin extrusion in normal human melanocytes". Paper presented in European Hair Research Society, 2012. Pacheco A, Queirós O, Preto A, Pinheiro C, Azevedo-Silva J, Moreira R, Pedro M, Baltazar F, Casal M. "Butyric acid increases monocarboxylate transporters (MCT) expression and enhances the cytotoxicity of the anti-tumoral agent 3-bromopyruvate (3-BP) in breast cancer cells". Paper presented in Jornadas Portuguesas de Genetica, 2012. Amorim R, Vilaça N, Preto A, Fonseca A M, Neves I C, Baltazar F. "Using zeolites as systems for drug delivery in in vitro models of colorectal carcinoma". Paper presented in II ICVS/3B meeting, 2012. Casal M, Pacheco A, Sá-Pessoa J, Azevedo-Silva J, Preto A, Pinheiro C, Ko Y H, Pedersen P L, Ulaszewski S, Goffeau A; Baltazar F, Paiva S, Queirós O. "Transport of lactic acid across plasma membrane: implications in health and biotechnology". Paper presented in SMYTE 30, 2012. Alves S, Chaves S R, Oliveira C, Seruca R, Corte-Real M, Preto A, Sousa M J. "Unravel the role of KRAS in autophagy control in colorectal carcinoma: Saccharomyces cerevisiae as a model system". Paper presented in 9th International Meeting on Yeast Apoptosis, 2012. Sousa MJ, Azevedo F, Pedras A, Marques C, Coutinho OP, Preto A, Geros H, Chaves SR, Corte-Real M. "Vacuole-mitochondrial cross-talk during apoptosis in yeast: a model for understanding lysosome-mitochondria-mediated apoptosis in mammals". 2011. Amorim R, Pereira H, Preto A, Baltazar F. "Monocarboxylate transporters – new molecular targets for colorectal carcinoma?". Paper presented in XX Porto Cancer Meeting, 2011. Pires S, Silva E, Queiroz MJRP, Preto A, Coutinho OP. "New synthetic di(hetero)arylamines raloxifen-like induce apoptosis of breast cancer cells and specifically bind to estrogen receptor". Paper presented in 4th International Symposium on Advances in Synthetic and Medicinal Chemistry, 2011. Amorim R, Martins S, Pereira H, Pinheiro C, Reis R, Longatto-Filho A, Preto A, Baltazar F. "Monocarboxylate transporters as new attractive targets for colorectal carcinoma therapy". Paper presented in 2nd Symposium of the International Society for Proton Dynamics in Cancer (ISPDC): Basic Research to Cancer Treatment, 2011. Nogueira E, Ferreira H, Preto A, Cavaco-Paulo A. "Characterization of several liposomal formulations for methotrexate delivery". Paper presented in 239th American Chemical Society National Meeting & Exposition, 2010. Marques C, Côrte-Real M, Coutinho OP, Preto A. "Response to acetate in colorectal carcinoma cells harboring different genetic backgrounds". Paper presented in Jornadas Portuguesas de Genética, 2010. Marques C, Côrte-Real M, Coutinho OP, Preto A. "The involvement of the lysosome in death induced by acetate in colorectal carcinoma cells harboring different genetic backgrounds". Paper presented in XVII Congresso Nacional de Bioquimica, 2010. Alves S, Chaves S, Oliveira C, Seruca R , Côrte-Real M, Preto A, Sousa MJ. "The role of human oncogene KRAS in autophagy regulation: Saccharomyces cerevisiae as a model system". Paper presented in XVII Congresso Nacional de Bioquimica, 2010. Pires S, Queiroz MJRP, Preto A, Coutinho OP. "Effect of two di(hetero)arylamines raloxifen-like in proliferation and apoptosis of breast cancer cells". Paper presented in XVII Congresso Nacional de Bioquimica, 2010. Preto A, Gonçalves J, Rebocho AP, Figueiredo J, Meireles AM, Rocha AS, Vasconcelos MH, Seca H, Seruca R, Soares P. "Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations". Paper presented in European Thyroid Association meeting, 2009. Ferreira M, Araújo R, Preto A, Gomes AC, Cavaco-Paulo A. "Capillary treatments using siRNA oligonucleotides- a new gene therapy tool?". Paper presented in 14th Annual Meeting European Hair Research Society, 2009. Xavier CPR, Lima CF, Preto A, Seruca R, Fernandes-Ferreira M, Pereira-Wilson C. "Quercetin, Luteolin and ursolic acid are potent inhibitors of proliferation in colorectal carcinoma cells: new therapeutic tools?". 2008. Preto, Ana. "Quercetin, Luteolin and ursolic acid are potent inhibitors of proliferation in colorectal carcinoma cells: new therapeutic tools?". Paper presented in 20th Meeting of the European Association for Cancer Research, 2008. Xavier CPR, Lima CF, Preto A, Seruca R, Fernandes-Ferreira M, Pereira-Wilson C. "Effects of natural compounds in PI3K/AKT and MAPK/ERK pathway on human colorectal cell lines". Paper presented in 2nd National Meeting of Signal Transduction, 2008. Preto A, Figueiredo ,J Velho S, Ribeiro AS, Soares P, Oliveira C, Seruca R. "BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAFV600E but not KRAS mutations". Paper presented in 11ª Reunião da Sociedade Portuguesa de Genética Humana, 2007. Rebocho AP, Trovisco V, Castro P, Preto A, Meireles AM, Rocha AS, Lima J, Moreira S, Feijão T, Botelho T, Máximo V. "RAF-1 in contrast to BRAF is not a mutational target of thyroid carcinogenesis". Paper presented in XIII Porto Cancer Meeting- Mismatch repair genes, Microsatellite instability, and Cancer, 2004. Velho S, Oliveira C, Cirnes L, Preto A, Hofstra RMW, Hamelin R, Seruca R. "RASSF1A methylation analysis in a series of colorectal cancer cell lines: ongoing work". Paper presented in XIII Porto Cancer Meeting- Mismatch repair genes, Microsatellite instability, and Cancer, 2004. Reis-Filho JS, Martins A, Preto A, Soares P, Schmitt FC. "Distribution of p63, Cytokeratin 5/6 and Cytokeratin 14 in 51 Normal and 450 Neoplastic Human Tissue Samples Using TARP-4 Multi-Tumor Tissue Microarray". Paper presented in 92th Annual Meeting of the United States and Canadian Academy of Pathology, 2003. Preto A, Reis Filho J S, Ricardo S, Soares P. "p63 expression in papillary and anaplastic carcinomas of the thyroid gland". Paper presented in XXIVth International Congress of the International Academy of Pathology, 2002. Preto A, Kipling D, Soares P, Wynford-Thomas D, Jones CJ. "Telomerase inhibition in cancer cells retaining wild-type p53". Paper presented in XIIth EuroCellPath Course- Cancer as a Disease of Genes and Gene Regulation, 2002. Preto A, Haughton M, Mehle C, Singhrao S, Kipling D, Soares P, Wynford-Thomas D, Jones CJ. "Telomerase inhibition in cancer cells retaining wild-type p53". Paper presented in Cancer Genetics and Tumor Suppressor Genes Meeting, 2002. Preto A, Haughton M, Kipling D, Soares P, Wynford-Thomas D and Jones CJ. "P53 mediated growth arrest in response to telomere erosion is retained in a subset of human cancer cell lines". Paper presented in American Association for Cancer Research Special Meeting: “Telomeres, telomerase and cancer", 2002. Preto A, Jones CJ, Kipling D, Soares P, Wynford-Thomas D, Sobrinho-Simões M. "Efeito da inibição da telomerase em linhas celulares de carcinoma papilar da tireóide". Paper presented in 5ª Reunião da Sociedade Portuguesa de Genética Humana, 2001.
Journal article	Brás, Ana Rita; Fernandes, Pedro; Moreira, Tiago; Morales-Sanfrutos, Julia; Sabidó, Eduard; Antunes, Alexandra M. M.; Valente, Andreia; Preto, Ana. "New Ruthenium-Cyclopentadienyl Complexes Affect Colorectal Cancer Hallmarks Showing High Therapeutic Potential". Pharmaceutics 15 6 (2023): 1731. http://dx.doi.org/10.3390/pharmaceutics15061731. 10.3390/pharmaceutics15061731 Gomes, Sara; Rodrigues, Ana Catarina; Pazienza, Valerio; Preto, Ana. "Modulation of the Tumor Microenvironment by Microbiota-Derived Short-Chain Fatty Acids: Impact in Colorectal Cancer Therapy". International Journal of Molecular Sciences 24 6 (2023): 5069. http://dx.doi.org/10.3390/ijms24065069. 10.3390/ijms24065069 Ferreira, J.C.C.; Sousa, R.P.C.L.; Preto, Ana; Sousa, M.J.; Gonçalves, M.S.T.. "Novel Benzo[a]phenoxazinium Chlorides Functionalized with Sulfonamide Groups as NIR Fluorescent Probes for Vacuole, Endoplasmic Reticulum, and Plasma Membrane Staining". International Journal of Molecular Sciences 24 (2023): Published Ferreira, João C. C.; Granja, Sara; Almeida, Ana F.; Baltazar, Fátima; Gonçalves, M. Sameiro T.; Preto, Ana; Sousa, Maria João. "Targeting Lysosomes in Colorectal Cancer: Exploring the Anticancer Activity of a New Benzo[a]phenoxazine Derivative". International Journal of Molecular Sciences 24 1 (2022): 614. http://dx.doi.org/10.3390/ijms24010614. 10.3390/ijms24010614 Gomes, Sara; Baltazar, Fátima; Silva, Elisabete; Preto, Ana. "Microbiota-Derived Short-Chain Fatty Acids: New Road in Colorectal Cancer Therapy". Pharmaceutics 14 11 (2022): 2359. http://dx.doi.org/10.3390/pharmaceutics14112359. 10.3390/pharmaceutics14112359 Ferreira, Anabela; Pereira, Flávia; Reis, Celso; Oliveira, Maria José; Sousa, Maria João; Preto, Ana. "Crucial Role of Oncogenic KRAS Mutations in Apoptosis and Autophagy Regulation: Therapeutic Implications". Cells 11 14 (2022): 2183. http://dx.doi.org/10.3390/cells11142183. 10.3390/cells11142183 Côrte-Real, Leonor; Brás, Ana Rita; Pilon, Adhan; Mendes, Nuno; Ribeiro, Ana Sofia; Martins, Tiago D.; Farinha, José Paulo S.; et al. "Biotinylated Polymer-Ruthenium Conjugates: In Vitro and In Vivo Studies in a Triple-Negative Breast Cancer Model". Pharmaceutics 14 7 (2022): 1388. http://dx.doi.org/10.3390/pharmaceutics14071388. 10.3390/pharmaceutics14071388 Pereira, Flávia; Ferreira, Anabela; Reis, Celso Albuquerque; Sousa, Maria João; Oliveira, Maria José; Preto, Ana. "KRAS as a Modulator of the Inflammatory Tumor Microenvironment: Therapeutic Implications". Cells 11 3 (2022): 398. http://dx.doi.org/10.3390/cells11030398. 10.3390/cells11030398 Gomes, Sara; Teixeira-Guedes, Catarina; Silva, Elisabete; Baltazar, Fátima; Preto, Ana. "Colon microbiota modulation by dairy-derived diet: new strategy for prevention and treatment of colorectal cancer". Food & Function 13 18 (2022): 9183-9194. http://dx.doi.org/10.1039/d2fo01720b. 10.1039/d2fo01720b C. Teixeira-Guedes; A. R. Brás; R. G. Teixeira; A. Valente; Preto, Ana. "Ruthenium(II)–Cyclopentadienyl-Derived Complexes as New Emerging Anti-Colorectal Cancer Drugs". Pharmaceutics 14 1293 (2022): https://hdl.handle.net/1822/80191. Published Azevedo-Silva, J.; Tavares-Valente, D.; Almeida, A.; O. Queirós; F. Baltazar; Y. H. Ko; P. L. Pedersen; Preto, Ana; M. Casal. "Cytoskeleton disruption by the metabolic inhibitor 3-bromopyruvate: implications in cancer therapy". Medical Oncology 39 121 (2022): Published João Carlos Canossa Ferreira; Carla Lopes; Ana Preto; M Sameiro T Gonçalves; Maria João Sousa. "Novel Nile Blue Analogue Stains Yeast Vacuolar Membrane, Endoplasmic Reticulum, and Lipid Droplets, Inducing Cell Death through Vacuole Membrane Permeabilization". Journal of Fungi (2021): https://www.mdpi.com/2309-608X/7/11/971. 10.3390/jof7110971 Gomes, Sara Daniela; Oliveira, Cláudia Suellen; Azevedo-Silva, João; Casanova, Marta R.; Barreto, Judite; Pereira, Helena; Chaves, Susana R.; et al. "The Role of Diet Related Short-Chain Fatty Acids in Colorectal Cancer Metabolism and Survival: Prevention and Therapeutic Implications". Current Medicinal Chemistry 27 24 (2020): 4087-4108. http://dx.doi.org/10.2174/0929867325666180530102050. 10.2174/0929867325666180530102050 Pilon, Adhan; Brás, Ana Rita; Côrte-Real, Leonor; Avecilla, Fernando; Costa, PJ; Preto, Ana; Garcia, Maria Helena; Valente, Andreia. "A New Family of Iron(II)-Cyclopentadienyl Compounds Shows Strong Activity Against Colorectal and Triple Negative Breast Cancer Cells.". Molecules (Basel, Switzerland) (2020): https://doi.org/10.3390/molecules25071592. 10.3390/molecules25071592 Côrte-Real, Leonor; Karas, Brittany; Brás, Ana Rita; Pilon, Adhan; Avecilla, Fernando; Marques, Fernanda; Preto, Ana; et al. "Ruthenium–Cyclopentadienyl Bipyridine–Biotin Based Compounds: Synthesis and Biological Effect". Inorganic Chemistry 58 14 (2019): 9135-9149. http://dx.doi.org/10.1021/acs.inorgchem.9b00735. 10.1021/acs.inorgchem.9b00735 Moreira, Tiago; Francisco, Rita; Comsa, Elisabeta; Duban-Deweer, Sophie; Labas, Valérie; Teixeira-Gomes, Ana-Paula; Combes-Soia, Lucie; et al. "Polymer “ruthenium-cyclopentadienyl” conjugates - New emerging anti-cancer drugs". European Journal of Medicinal Chemistry 168 (2019): 373-384. http://dx.doi.org/10.1016/j.ejmech.2019.02.061. 10.1016/j.ejmech.2019.02.061 Pereira-Vieira, Joana; Azevedo-Silva, João; Preto, Ana; Casal, Margarida; Queirós, Odília. "Extracellular conditions influence the MCT1, MCT4 and CD147 expression and 3-bromopyruvate effect in colorectal cancer cells". Biological Chemistry 400 6 (2019): 787-799. http://dx.doi.org/10.1515/hsz-2018-0411. 10.1515/hsz-2018-0411 Ohradanova-Repic, Anna; Nogueira, Eugénia; Hartl, Ingrid; Gomes, Andreia C.; Preto, Ana; Steinhuber, Eva; Mühlgrabner, Vanessa; et al. "Fab antibody fragment-functionalized liposomes for specific targeting of antigen-positive cells". Nanomedicine: Nanotechnology, Biology and Medicine 14 1 (2018): 123-130. http://dx.doi.org/10.1016/j.nano.2017.09.003. 10.1016/j.nano.2017.09.003 Ohradanova-Repic, Anna; Nogueira, E.; Hartl, Ingrid; Gomes, Andreia C.; Preto, Ana; Steinhuber, Eva; Mühlgrabner, Vanessa; et al. "Fab antibody fragment-functionalized liposomes for specific targeting of antigen-positive cells". (2018): http://hdl.handle.net/1822/51164. 10.1016/j.nano.2017.09.003 Gomes, Sara Daniela; Oliveira, Claudia Suellen; Azevedo-Silva, João; Casanova, Marta; Barreto, Judite; Pereira, Helena; Chaves, Susana; et al. "The role of diet related short-chain fatty acids in colorectal cancer metabolism and survival: prevention and therapeutic implications". (2018): http://hdl.handle.net/1822/58525. 10.2174/0929867325666180530102050 Cazzanelli, Giulia; Pereira, Flávia; Alves, Sara; Francisco, Rita; Azevedo, Luísa; Dias Carvalho, Patrícia; Almeida, Ana; et al. "The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis". (2018): http://hdl.handle.net/1822/60338. 10.3390/cells7020014 Teixeira, Ricardo G.; Brás, Ana Rita; Côrte-Real, Leonor; Tatikonda, Rajendhraprasad; Sanches, Anabela; Robalo, M. Paula; Avecilla, Fernando; et al. "Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells". (2018): http://hdl.handle.net/1822/50165. 10.1016/j.ejmech.2017.11.059 Casanova, Marta; Azevedo-Silva, João; Rodrigues, L. R.; Preto, Ana. "Colorectal cancer cells increase the production of short chain fatty acids by Propionibacterium freudenreichii impacting on cancer cells survival". (2018): http://hdl.handle.net/1822/54874. 10.3389/fnut.2018.00044 Nogueira, E.; Freitas, Jaime; Loureiro, Ana Isabel Sá; Nogueira, Patrícia; Gomes, Andreia C.; Preto, Ana; Carmo, Alexandre M.; Moreira, Alexandra; Cavaco-Paulo, Artur. "Neutral PEGylated liposomal formulation for efficient folate-mediated delivery of MCL1 siRNA to activated macrophages". (2017): http://hdl.handle.net/1822/47698. 10.1016/j.colsurfb.2017.04.023 Nogueira, Eugénia; Gomes, Andreia C.; Preto, Ana; Cavaco-Paulo, Artur. "Folate-targeted nanoparticles for rheumatoid arthritis therapy". Nanomedicine: Nanotechnology, Biology and Medicine 12 4 (2016): 1113-1126. http://dx.doi.org/10.1016/j.nano.2015.12.365. 10.1016/j.nano.2015.12.365 Martins, S.F.; Amorim, R.; Viana-Pereira, M.; Pinheiro, C.; Costa, R.F.A.; Silva, P.; Couto, C.; et al. "Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis". BMC Cancer 16 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84979211096&partnerID=MN8TOARS. 10.1186/s12885-016-2566-9 Nogueira, E.; Gomes, A.; Preto, A.; Cavaco-Paulo, A.; Nogueira, Eugenia; Gomes, Andreia; Preto, Ana; et al. "Update on therapeutic approaches for rheumatoid arthritis". Current Medicinal Chemistry 23 21 (2016): 2190-2203. http://www.scopus.com/inward/record.url?eid=2-s2.0-84986573074&partnerID=MN8TOARS. 10.2174/092986732366616031612506 Azevedo-Silva, J.; Queirós, O.; Baltazar, F.; Ulaszewski, S.; Goffeau, A.; Ko, Y.H.; Pedersen, P.L.; et al. "The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside". Journal of Bioenergetics and Biomembranes 48 4 (2016): 349-362. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979641440&partnerID=MN8TOARS. 10.1007/s10863-016-9670-z Nogueira, E.; Cruz, C.F.; Loureiro, A.; Nogueira, P.; Freitas, J.; Moreira, A.; Carmo, A.M.; et al. "Assessment of liposome disruption to quantify drug delivery in vitro". Biochimica et Biophysica Acta - Biomembranes 1858 2 (2016): 163-167. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948166510&partnerID=MN8TOARS. 10.1016/j.bbamem.2015.11.008 Ferro, Suellen; Azevedo-Silva, João; Casal, Margarida; Côrte-Real, Manuela; Baltazar, Fátima; Preto, Ana; Ferro, S.; et al. "Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications". Oncotarget 7 43 (2016): 70639-70653. http://hdl.handle.net/1822/48145. 10.18632/oncotarget.12156 Nogueira, E.; Mangialavori, I.C.; Loureiro, A.; Azoia, N.G.; Sárria, M.P.; Nogueira, P.; Freitas, J.; et al. "Peptide Anchor for Folate-Targeted Liposomal Delivery". Biomacromolecules 16 9 (2015): 2904-2910. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941584525&partnerID=MN8TOARS. 10.1021/acs.biomac.5b00823 Nogueira, E.; Lager, F.; Le Roux, D.; Nogueira, P.; Freitas, J.; Charvet, C.; Renault, G.; et al. "Enhancing methotrexate tolerance with folate tagged liposomes in arthritic mice". Journal of Biomedical Nanotechnology 11 12 (2015): 2243-2252. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941551653&partnerID=MN8TOARS. 10.1166/jbn.2015.2170 Nogueira, E.; Gomes, A.C.; Preto, A.; Cavaco-Paulo, A.; Gomes, Andreia C.; Preto, Ana; Cavaco-Paulo, Artur. "Design of liposomal formulations for cell targeting". Colloids and Surfaces B: Biointerfaces 136 (2015): 514-526. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943601733&partnerID=MN8TOARS. 10.1016/j.colsurfb.2015.09.034 Amorim, R.; Pinheiro, C.; Miranda-Gonçalves, V.; Pereira, H.; Moyer, M.P.; Preto, A.; Baltazar, F.; et al. "Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells". Cancer Letters 365 1 (2015): 68-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930823940&partnerID=MN8TOARS. 10.1016/j.canlet.2015.05.015 Oliveira, C.S.F.; Pereira, H.; Alves, S.; Castro, L.; Baltazar, F.; Chaves, S.R.; Preto, A.; et al. "Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagyindependent degradation of damaged mitochondria". Cell Death and Disease 6 6 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84989827781&partnerID=MN8TOARS. 10.1038/cddis.2015.157 Castro, Lisandra; Alves, Sara; Chaves, Susana R.; Costa, Jose Luis; Soares, Paula; Preto, Ana; Castro, L.; et al. "RAF-1 promotes survival of thyroid cancer cells harboring RET/PTC1 rearrangement independently of ERK activation". Molecular and Cellular Endocrinology 415 (2015): 64-75. http://hdl.handle.net/1822/50155. 10.1016/j.mce.2015.08.006 Loureiro, Ana Isabel Sá; Bernardes, Gonçalo J. L.; Shimanovich, Ulyana; Sárria, M. P.; Nogueira, Eugénia; Preto, Ana; Gomes, Andreia; et al. "Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors". Nanomedicine: Nanotechnology, Biology, and Medicine 11 5 (2015): 1077-1083. http://hdl.handle.net/1822/35305. 10.1016/j.nano.2015.02.022 Silva, João Sérgio Azevedo Lima; Queirós, Odília; Ribeiro, Ana; Baltazar, Fátima; Ko H. Young; Pedersen, Peter L.; Preto, Ana; Casal, Margarida. "The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH". (2015): http://hdl.handle.net/1822/42779. 10.1042/BJ20140921 Pereira, H; Oliveira, C S F; Castro, L.; Preto, Ana; Chaves, S. R.; Côrte-Real, Manuela. "Yeast as a tool to explore cathepsin D function". (2015): http://hdl.handle.net/1822/50170. 10.15698/mic2015.07.212 Alves, Sara; Castro, Lisandra; Fernandes, Maria Sofia; Francisco, Rita; Castro, Paula; Priault, Muriel; Chaves, Susana Rodrigues; et al. "Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy". Oncotarget 6 31 (2015): 30787-30802. http://hdl.handle.net/1822/48486. 10.18632/oncotarget.5021 Loureiro, Ana Isabel Sá; Nogueira, Eugénia Sofia Costa; Azóia, Nuno G.; Sárria, M. P.; Abreu, Ana S.; Shimanovich, Ulyana; Rollett, Alexandra; et al. "Size controlled protein nanoemulsions for active targeting of folate receptor positive cells". Colloids and Surfaces B: Biointerfaces 135 (2015): 90-98. http://hdl.handle.net/1822/37157. 10.1016/j.colsurfb.2015.06.073 Nogueira, E.; Mangialavori, Irene C.; Loureiro, Ana; Azóia, Nuno G.; Sarria, Marisa P.; Nogueira, Patrícia; Freitas, Jaime; et al. "Peptide anchor for folate-targeted liposomal delivery". (2015): http://hdl.handle.net/1822/37622. 10.1021/acs.biomac.5b00823 Baltazar, Fátima; Pinheiro, Céline; Santos, Filipa Morais; Silva, J. Azevedo; Queirós, Odília; Preto, Ana; Casal, Margarida; et al. "Monocarboxylate transporters as targets and mediators in cancer therapy response". Histology and Histopathology 29 12 (2014): 1511-1524. http://hdl.handle.net/1822/32518. Marques, C.; Oliveira, C.S.F.; Alves, S.; Chaves, S.R.; Coutinho, O.P.; Côrte-Real, M.; Preto, A.; et al. "Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release". Cell Death and Disease 4 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84875984111&partnerID=MN8TOARS. 10.1038/cddis.2013.29 Vinagre, João; Almeida, Ana; Pópulo, Helena; Batista, Rui; Lyra, Joana; Pinto, Vasco; Coelho, Ricardo; et al. "Frequency of TERT promoter mutations in human cancers". Nature Communications 4 (2013): http://hdl.handle.net/10400.22/3182. 10.1038/ncomms3185 Matamá, Maria Teresa; Araújo, Rita; Preto, Ana; Paulo, Artur Cavaco; Gomes, A. C.; Matamá, T.; Araújo, R.; et al. "In vitro induction of melanin synthesis and extrusion by tamoxifen". International Journal of Cosmetic Science 35 4 (2013): 368-374. http://hdl.handle.net/1822/24554. 10.1111/ics.12052 Nogueira, Eugénia Sofia Costa; Loureiro, Ana; Nogueira, Patrícia; Freitas, Jaime; Almeida, Catarina R.; Harmark, Johan; Hebert, Hans; et al. "Liposome and protein based stealth nanoparticles". Faraday Discussions 166 (2013): 417-429. http://hdl.handle.net/1822/27525. 10.1039/c3fd00057e Queirós, O.; Preto, A.; Pacheco, A.; Pinheiro, C.; Azevedo-Silva, J.; Moreira, R.; Pedro, M.; et al. "Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate". Journal of Bioenergetics and Biomembranes 44 1 (2012): 141-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858708932&partnerID=MN8TOARS. 10.1007/s10863-012-9418-3 Queirós, Odília; Preto, Ana; Pacheco, António; Pinheiro, Céline; Silva, João Azevedo; Moreira, Roxana; Pedro, Madalena; et al. "3-bromopyruvate, butyrate, monocarboxylate transporters, warburg effect". (2012): http://hdl.handle.net/1822/21366. 10.1007/s10863-012-9418-3 Soares, P.; Lima, J.; Preto, A.; Castro, P.; Vinagre, J.; Celestino, R.; Couto, J.P.; et al. "Genetic alterations in poorly differentiated and undifferentiated thyroid carcinomas". Current Genomics 12 8 (2011): 609-617. http://www.scopus.com/inward/record.url?eid=2-s2.0-82055176819&partnerID=MN8TOARS. 10.2174/138920211798120853 Sousa, M.J.; Azevedo, F.; Pedras, A.; Marques, C.; Coutinho, O.P.; Preto, A.; Geros, H.; et al. "Vacuole-mitochondrial cross-talk during apoptosis in yeast: A model for understanding lysosome-mitochondria-mediated apoptosis in mammals (Biochemical Society Transactions (2011) 39, (1533-1537))". Biochemical Society Transactions 39 6 (2011): 1533-1537. http://www.scopus.com/inward/record.url?eid=2-s2.0-81855198089&partnerID=MN8TOARS. 10.1042/BST0391533 Preto, A.; Gonçalves, J.; Rebocho, A.P.; Figueiredo, J.; Meireles, A.M.; Rocha, A.S.; Vasconcelos, H.M.; et al. "Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations". BMC Cancer 9 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-70749088911&partnerID=MN8TOARS. 10.1186/1471-2407-9-387 Soares, P.; Preto, A.; Sobrinho-Simões, M.. "BRAFV600E mutation in papillary thyroid carcinoma: A potential target for therapy?". Expert Review of Endocrinology and Metabolism 4 5 (2009): 467-480. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449944885&partnerID=MN8TOARS. 10.1586/eem.09.29 Xavier, Cristina P. R.; Lima, Cristóvão F.; Preto, Ana; Seruca, Raquel; Ferreira, Manuel Fernandes; Wilson, Cristina Pereira; Xavier, C.P.R.; et al. "Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells". Cancer Letters 281 2 (2009): 162-170. http://hdl.handle.net/1822/12236. 10.1016/j.canlet.2009.02.041 Sobrinho-Simões, M.; Máximo, V.; Rocha, A.S.; Trovisco, V.; Castro, P.; Preto, A.; Lima, J.; Soares, P.. "Intragenic Mutations in Thyroid Cancer". Endocrinology and Metabolism Clinics of North America 37 2 (2008): 333-362. http://www.scopus.com/inward/record.url?eid=2-s2.0-43849083525&partnerID=MN8TOARS. 10.1016/j.ecl.2008.02.004 Preto, A.; Figueiredo, J.; Velho, S.; Ribeiro, A.S.; Soares, P.; Oliveira, C.; Seruca, R.. "BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF^V600Ebut not KRAS mutations". Journal of Pathology 214 3 (2008): 320-327. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949208776&partnerID=MN8TOARS. 10.1002/path.2295 Meireles, A.M.; Preto, A.; Rocha, A.S.; Rebocho, A.P.; Máximo, V.; Pereira-Castro, I.; Moreira, S.; et al. "Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines". Thyroid 17 8 (2007): 707-715. http://www.scopus.com/inward/record.url?eid=2-s2.0-36649017735&partnerID=MN8TOARS. 10.1089/thy.2007.0097 Trovisco, V.; Soares, P.; Preto, A.; Castro, P.; Máximo, V.; Sobrinho-Simões, M.. "Molecular genetics of papillary thyroid carcinoma - Great expectations...". Arquivos Brasileiros de Endocrinologia e Metabologia 51 5 (2007): 643-653. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348823686&partnerID=MN8TOARS. Preto, A.; Moutinho, C.; Velho, S.; Oliveira, C.; Rebocho, A.P.; Figueiredo, J.; Soares, P.; Lopes, J.M.; Seruca, R.. "A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation". Virchows Archiv 450 6 (2007): 619-626. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250805986&partnerID=MN8TOARS. 10.1007/s00428-007-0420-9 Oliveira, C.; Velho, S.; Moutinho, C.; Ferreira, A.; Preto, A.; Domingo, E.; Capelinha, A.F.; et al. "KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression". Oncogene 26 1 (2007): 158-163. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846048042&partnerID=MN8TOARS. 10.1038/sj.onc.1209758 Oliveira, C.; Velho, S.; Domingo, E.; Preto, A.; Hofstra, R.M.W.; Hamelin, R.; Yamamoto, H.; Seruca, R.; Schwartz Jr., S.. "Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer". Oncogene 24 51 (2005): 7630-7634. http://www.scopus.com/inward/record.url?eid=2-s2.0-27844458489&partnerID=MN8TOARS. 10.1038/sj.onc.1208906 Sobrinho-Simões, M.; Preto, A.; Rocha, A.S.; Castro, P.; Máximo, V.; Fonseca, E.; Soares, P.. "Molecular pathology of well-differentiated thyroid carcinomas". Virchows Archiv 447 5 (2005): 787-793. http://www.scopus.com/inward/record.url?eid=2-s2.0-28444485337&partnerID=MN8TOARS. 10.1007/s00428-005-0065-5 Trovisco, V.; Soares, P.; Preto, A.; De Castro, I.V.; Lima, J.; Castro, P.; Máximo, V.; et al. "Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients' age but not with tumour aggressiveness". Virchows Archiv 446 6 (2005): 589-595. http://www.scopus.com/inward/record.url?eid=2-s2.0-21544464303&partnerID=MN8TOARS. 10.1007/s00428-005-1236-0 Máximo, V.; Botelho, T.; Capela, J.; Soares, P.; Lima, J.; Taveira, A.; Amaro, T.; et al. "Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hürthle cell) tumours of the thyroid". British Journal of Cancer 92 10 (2005): 1892-1898. http://www.scopus.com/inward/record.url?eid=2-s2.0-20344366798&partnerID=MN8TOARS. 10.1038/sj.bjc.6602547 Cameselle-Teijeiro, J.; Preto, A.; Soares, P.; Sobrinho-Simões, M.; Burstein, D.E.; Unger, P.; Nagi, C.; Wang, B.Y.. "A stem cell role for thyroid solid cell nests [1] (multiple letters)". Human Pathology 36 5 (2005): 590-592. http://www.scopus.com/inward/record.url?eid=2-s2.0-20144367737&partnerID=MN8TOARS. 10.1016/j.humpath.2005.02.010 Preto, A.; Singhrao, S.K.; Haughton, M.F.; Kipling, D.; Wynford-Thomas, D.; Jones, C.J.. "Telomere erosion triggers growth arrest but not cell death in human cancer cells retaining wild-type p53: Implications for antitelomerase therapy". Oncogene 23 23 (2004): 4136-4145. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942537690&partnerID=MN8TOARS. 10.1038/sj.onc.1207564 Máximo, V.; Preto, A.; Crespo, A.; Machado, J.C.; Soares, P.; Sobrinho-Simões, M.. "Core I gene is overexpressed in Hürthle and non-Hürthle cell microfollicular adenomas and follicular carcinomas of the thyroid". BMC Cancer 4 (2004): http://www.scopus.com/inward/record.url?eid=2-s2.0-3042757410&partnerID=MN8TOARS. 10.1186/1471-2407-4-12 Preto, A.; Cameselle-Teijeiro, J.; Moldes-Boullosa, J.; Soares, P.; Cameselle-Teijeiro, J.F.; Silva, P.; Reis-Filho, J.S.; et al. "Telomerase expression and proliferative activity suggest a stem cell role for thyroid solid cell nests". Modern Pathology 17 7 (2004): 819-826. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042829278&partnerID=MN8TOARS. 10.1038/modpathol.3800124 Soares, P.; Trovisco, V.; Rocha, A.S.; Lima, J.; Castro, P.; Preto, A.; Máximo, V.; et al. "BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC". Oncogene 22 29 (2003): 4578-4580. http://www.scopus.com/inward/record.url?eid=2-s2.0-0043170833&partnerID=MN8TOARS. 10.1038/sj.onc.1206706 Reis-Filho, J.S.; Preto, A.; Soares, P.; Ricardo, S.; Cameselle-Teijeiro, J.; Sobrinho-Simões, M.; Reis-Filho, Jorge S.; et al. "p63 expression in solid cell nests of the thyroid: Further evidence for a stem cell origin". Modern Pathology 16 1 (2003): 43-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037260034&partnerID=MN8TOARS. 10.1097/01.MP.0000047306.72278.39 Reis Filho, Jorge S.; Simpson, Pete T.; Martins, Albino; Preto, Ana; Gartner, Fátima; Schmitt, Fernando C.; Reis-Filho, J.S.; et al. "Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray". Virchows Archiv 443 2 (2003): 122-132. http://hdl.handle.net/1822/1957. 10.1007/s00428-003-0859-2 Preto, A.; Reis-Filho, J.S.; Ricardo, S.; Soares, P.. "P63 expression in papillary and anaplastic carcinomas of the thyroid gland: Lack of an oncogenetic role in tumorigenesis and progression". Pathology Research and Practice 198 7 (2002): 449-454. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036024693&partnerID=MN8TOARS. Zemzoumi, K.; Guilvard, E.; Sereno, D.; Preto, A.; Benlemlih, M.; Cordeiro Da Silva, A.; Lemesre, J.-L.; Ouaissi, A.; Preto, Ana. "Cloning of a Leishmania major gene encoding for an antigen with extensive homology to ribosomal protein S3a". Gene 240 1 (1999): 57-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032720484&partnerID=MN8TOARS. 10.1016/S0378-1119(99)00433-3
Magazine article	Preto, Ana. "Novas terapêuticas no carcinoma da tireóide: novos alvos moleculares?", Revista Mundo Médico, edição nº 54, 2007
Thesis / Dissertation	"Identificação dos mecanismos de escape à acção da p53 na carcinogénese humana usando as neoplasias da tireóide como modelo de estudo". PhD, Universidade do Porto Faculdade de Medicina, 2004.

Intellectual property

Patent

Valente A., Garcia M.H., Preto A., Brás A.R. 2023. ""USE OF AN ORGANOMETALLIC RUTHENIUM COMPOUND FOR THE PREVENTION AND/OR TREATMENT OF DISEASES"".
Granted/Issued
Paulo, Artur Cavaco; Preto, Ana; Nogueira, Eugénia; Gomes, A. C.. 2013. "Liposomes and corresponding production method".
Granted/Issued
Paulo, Artur Cavaco; Gomes, A. C.; Silva, Raquel; Loureiro, Ana; Preto, Ana. 2013. "FORMULATIONS FOR MICELLE FORMATION COMPRISING A PROTEIN AND METHODS PREPARATION THEREOF".
Granted/Issued

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/03/31	“Microbiota-derived short-chain fatty acids disturb cell survival and glycolytic metabolism: new strategy to fight colorectal cancer.”	India\|EMBO Lecture Course on “Tumour metabolism: Current understanding and opportunities for novel drug discovery” EMBO (Noida, India)
2022/09/20	“Specific Targeting for Colorectal Cancer Harbouring KRAS Mutation Using a New Ruthenium-Based Agent”.	6th Cancer World Congress Cancer World Congress (Lisboa, Portugal)
2021/11	New ruthenium-cyclopentadienyl agents as a new strategy to fight colorectal cancer	7th International Electronic Conference on Medicinal Chemistry (Basel, Switzerland)
2021/11	The potential of novel benzo[a]phenoxazine derivatives for colorectal cancer treatment	7th International Electronic Conference on Medicinal Chemistry (Basel, Switzerland)
2021/08	Antifungal properties and NIR fluorescent staining of cells with benzo[a]phenoxazinium chlorides having a sulfonamide group	Virtual Conference on Chemistry and its Applications
2021	How yeast and cancer cells link-up to study colorectal cancer	Palestra por convite na Unidade Curricular: BASES MOLECULARES DO CANCRO E PRINCÍPIOS TERAPÊUTICOS Universidade do Minho, Escola de Medicina (Braga, Portugal)
2020/01	Fighting Breast Cancer with Ruthenium-based Metallodrugs endowed with Tumor-targeting Vectors	13º Encontro Nacional de Química Orgânica/ 6º Encontro Nacional de Química Terapêutica Universidade de Aveiro (Aveiro, Portugal)
2019	New Ruthenium-Cyclopentadienyl Complexes Bearing Biotinylated (Macro)Ligands: Targeting Strategies To Fight Metastatic Breast Cancer	6th Young Medicinal Chemist Symposium
2019	Strategies for targeted cancer therapy using ruthenium-cyclopentadienyl complexes	3rd International Caparica Christmas Congress on Translational Chemistry 2019
2018/12/06	The role of diet related short chain fatty acid acetate in colorectal cancer	Conferences in Oncobiology Universidade do Porto, Faculdade de Farmácia (Porto, Portugal)
2018/11	The role of diet related short chain fatty acid acetate in colorectal cancer: prevention and therapeutic implications	International workshop NO-CANCER 2018: Understanding Cancer Cell Biology to improve Diagnosis and Therapy (Novara, Italy)
2018/05/30	How yeast and cancer cells meet as a tool to identify new molecular targets for colorectal cancer	Seminário por convite Centro de Investigaciones Biomedicas (CINBIO), University of Vigo (Vigo, Spain)
2018/05/09	How yeast and cancer cells meet as a tool to identify new molecular targets for colorectal cancer	Seminário por convite Centro de Química Estrutural (CEQUIM), Faculdade de Ciências, Universidade de Lisboa (Lisboa, Portugal)
2018/04/19	How yeast and cancer cells meet as a tool to identify new molecular targets for colorectal cancer	Seminário por convite - Biosciences seminar University of Brunel (Londres, United Kingdom)
2018	Novel ruthenium cyclopentadienyl complexes bearing bipyridine based (macro)ligands with strong activity towards cancer cells	4th European Conference on Smart Inorganic Polymers
2018	On the mode of action of anticancer ruthenium-polymer conjugates	International Conference on Coordination Chemistry
2018	Unveil the KRAS/Galectin-3/p16INK4a triple axis regulation in colorectal cancer	Porto Cancer Meeting
2017/11/22	How yeast and cancer cells join to understand the role of KRAS in autophagy	DBio Seminar Universidade do Minho, Departamento de Biologia
2017/04/27	Cancer definition and hallmarks	Curso de Pós-Graduação ONCOBIOLOGY CESPU
2017/02/02	Telomerase and cancer	ONCOBIOLOGY, Programa GABBA IPATIMUP (Porto, Portugal)
2017	Mitochondrial ROS accumulation sensitizes colorectal cancer cells to acetate and cathepsin D inhibitors combination therapy	MitoPorto – Advances in Mitochondrial Research
2017	Cancer targeted therapy: the next generation of metallodrugs	18th International Conference on Biological Inorganic Chemistry
2016/05/02	Cancer definition and hallmarks	Curso de Pós-Graduação ONCOBIOLOGY CESPU
2016	Transport of monocarboxylic acids in cancer cells: implications of short chain fatty acids and 3-bromopyruvate for cancer therapy	34th Small meeting on yeast transport and energetics
2016	Targeting cancer with new multifunctional metallodrugs	World Conference on Cancer Research and Therapy (Miami, United States)
2016	Transport of short chain fatty acids and 3-bromopyruvate in cancer cells: implications for cancer therapy	Sociedade Portuguesa de Bioquimica
2016	New molecular targets and therapeutic approaches for colorectal cancer	XVII Jornadas de Biologia Aplicada Universidade do Minho, Departamento de Biologia
2016	Unravel the impact of mutant KRAS alleles on autophagy regulation in colorectal cancer	DBio Seminar Universidade do Minho, Departamento de Biologia
2015/09/23	Unveil the role of mutated KRAS signaling in colorectal carcinoma: towards identification of new molecular targets	Curso de Pós-Graduação - GlycoBiology SUMMER SCHOOL Universidade do Minho, Departamento de Biologia
2015	On the mode of action of new promising anticancer agents: multifunctional polymer-ruthenium conjugates	4th International Conference on Medicinal Chemistry & Computer Aided Drug Designing (Atlanta, United States)
2015	Multifunctional polymer-ruthenium cyclopentadienyl complexes: new promising anticancer agents	I International Caparica Christmas Congress on Translational Chemistry (Caparica, Portugal)
2015	Colon cancer-related mutant KRAS alleles function as positive regulators of autophagy	IMYA
2014	Characterization of 3-bromopyruvate uptake in breast cancer cells	4th Annual Meeting of the International Society of Proton Dynamics in Cancer
2014	The yeast vacuolar protease Pep4p unveils a novel function of the human Cathepsin D during acetate-induced mitochondrial apoptosis in colorectal carcinoma cells	IMYA X INTERNATIONAL MEETING ON YEAST APOPTOSIS
2014	Characterization of peptides as a membrane anchor in liposomes for the incorporation of ligands for specific targeting	8th International Conference on Polymer and Fiber Biotechnology
2014	Yeast and mammalian cells as complementary models to identify new molecular targets for colorectal carcinoma	II AEICBAS Biomedical Congress Universidade do Porto
2014	Cell signaling: Signal Transduction in Cancer	Fundamentals of Genetics, Development and Neoplasia” com o titulo ICVS
2013	New peptide-linker of folate-target liposomes for specific drug delivery	246th ACS Meeting
2013	Characterization of 3-bromopyruvate uptake in breast cancer cells	4th Annual Meeting of the International Society of Proton Dynamics in Cancer
2013	Novel therapeutic approaches for colorectal cancer: the role of small chain fatty acids and oncogene KRAS	Ciência Falada ICVS
2012	Liposomal formulations for specific drug delivery	243th ACS
2012	Discovering messenger RNA and micro RNA expression patterns in normal, greying hair	European Hair Research Society
2012	NANOFOL: Nanobiodispositivos com folato para diagnóstico/terapêutica integrados de doenças crónicas inflamatórias	workshop “Ciência & Engenharia: Investigação e inovação para o desenvolvimento sustentável"
2011	What yeast can tell us about how cells commit suicide?	14th Portugaliae Genetica
2011	Vacuole-mitochondrial crosstalk during acetic acid-induced yeast apoptosis	8th International Meeting on Yeast Apoptosis
2011	Monocarboxylate transporters – new molecular targets for colorectal carcinoma?	Zing Cancer Conference 2011: from carcinogenesis to cancer therapy
2010	A yeast heterologous expression system to understand the role of human oncogene KRAS in autophagy regulation	Jornadas Portuguesas de Genética Universidade do Minho
2010	Know your body to control it: a journey from basic science to nanotechnology	I Jornadas de Bioquímica
2008	KRAS and BRAF mutations in colorectal cancer progression	Porto Cancer meeting
2007	Novas terapêuticas no carcinoma da tireóide: efeito biológico da inibição farmacológica de cinases em linhas celulares do carcinoma da tireóide	Tumores endócrinos-7º simpósio nacional
2007	Sensitivity of thyroid cancer cells to BAY 43-9006 is distinct from BRAF specific inhibition. Biological and therapeutic implications	1st Iberic Meeting on Medical Chemistry-Anticancer Agents
2007	MAP kinase signalling pathway in gastrointestinal cancer	1st Iberic Meeting on Medical Chemistry-Anticancer Agents
2007	Proliferação e agentes anti-proliferativos no tratamento do cancro	Colóquios 2007 para Professores do Liceu IPATIMUP (Porto, Portugal)
2004	Biological effects of kinase inhibition in thyroid cancer cell lines using a pharmacological approach	Thyroid meeting IPATIMUP (Porto, Portugal)
2003	P53 mediated growth arrest in response to telomere erosion is retained in a subset of human cancer cell lines	1º Congresso da Sociedade Portuguesa de Ciências Farmacêuticas
2003	P53 mediated growth arrest in response to telomere erosion is retained in a subset of human cancer cell lines	European Thyroid Association Annual Meeting
2002	p63 in Solid cell nests:further evidence for a stem cell origin	XXIVth International Congress of the International Academy of Pathology

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2019 - Current	New ruthenium-based anticancer agents: promising therapeutic approach towards colorectal cancer Supervisor	Molecular and Environmental Biology (PhD) Universidade do Minho, Portugal
2019 - Current	Uncover the role of KRAS/Galectin-3 loop in the crosstalk between colorectal cancer cells and tumor-associated macrophages: therapeutic implications Supervisor	Doctoral Program in Molecular and Environmental Biology (PhD) Universidade do Minho, Portugal
2023 - 2024	The role of microbiota-derived short-chain fatty acids in extracellular vesicles production by colorectal cancer Supervisor of Daniela Oliveira Macedo	Biophysics and Bionanosystems (Master) Universidade do Minho, Portugal
2023 - 2024	Unravelling the anticancer effect of a new ruthenium-agent targeting KRAS mutation in pancreatic cancer Supervisor of Cláudia Matos da Costa	Molecular Genetics (Master) Universidade do Minho, Portugal
2023 - 2024	Exploring the effect of a new ruthenium-agent targeting KRAS mutation in pancreatic cancer using in vitro and in vivo models Supervisor of Ana Cristina Ferreira Moreira	Molecular Genetics (Master) Universidade do Minho, Portugal
2023 - 2024	Anticancer effects of postbiotics in colorectal and pancreatic cancer Supervisor of Vanessa Alejandra Bernardo Rodriguez	Molecular Genetics (Master) Universidade do Minho, Portugal
2022 - 2023	“Uncover the mechanism of action of new FeCp compounds in colorectal cancer cells” Supervisor	Biologia Celular e Molecular (Master) Universidade do Porto Faculdade de Ciências, Portugal
2022 - 2023	Short-chain fatty acids as potential modulators of new ruthenium anticancer drug in colorectal cancer therapy Supervisor of Renata Filipe Oliveira Matos	Applied Biochemistry (Master) Universidade do Minho, Portugal
2018 - 2023	The role of Bcl-2 protein family and Beclin-1 in KRAS-mediated regulation of apoptosis/autophagy using yeast and colorectal cancer as models. Co-supervisor	Molecular and Environmental Biology (PhD) Universidade do Minho, Portugal
2018 - 2023	Unveiling the role of diet microbiome-derived short chain fatty acids in prevention and therapy of colorectal cancer using a colon-on-a-chip model Supervisor	Molecular and Environmental Biology (PhD) Universidade do Minho, Portugal
2017 - 2023	Uncovering all death induction mechanisms and anti-cancer properties of novel benzo[a]phenoxazine derivatives Co-supervisor	Molecular and Environmental Biology (PhD) Universidade do Minho, Portugal
2020 - 2021	Supervisor of Catarina Teixeira with a junior researcher grant as part of the project Lead4Target: Fighting metastatic cancers: prime time for ruthenium; PTDC/QUI-QIN/28662/2017 Supervisor	Universidade do Minho, Portugal
2014 - 2020	Metabolic remodelling of colorectal carcinoma: crosstalk between lactate transport and oncogenic signalling Co-supervisor	Health Sciences (PhD) Universidade do Minho, Portugal
2019 - 2019	Toxicity assessment of products for the agri-food sector potentially implicated in human wellbeing Supervisor	Applied Biochemistry (Master) Universidade do Minho, Portugal
2019 - 2019	Elucidating the role of the Coxsackie and Adenovirus Receptor (CAR) in regulating AKT signaling and glucose metabolism in cancer and inflammation Co-supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2019 - 2019	The role of CXCR4 in cancer exosomes and metastasis Co-supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2019 - 2019	The role of aberrant glycosylation of CD44 in gastrointestinal carcinoma and its application for cancer biomarker purposes Co-supervisor	Applied Biochemistry (Master) Universidade do Minho, Portugal
2019 - 2019	Exploring the anticancer effect of new ruthenium-biotinylated conjugates in colorectal cancer Supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2019 - 2019	Toxicity assessment of combinations of food contaminants and additives potentially implicated in human wellbeing Supervisor	Applied Biochemistry (Master) Universidade do Minho, Portugal
2018/07 - 2018/12	Research project RuPMC (IF/01302/2013) Co-supervisor	Universidade do Minho, Portugal
2018 - 2018	The role of oncogenic KRAS in colorectal cancer: from subcellular localization upon autophagy induction to new therapeutic drugs” Supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2018 - 2018	Unraveling the molecular targets of new ruthenium-based anticancer drugs Supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2018 - 2018	Understanding the role of KRAS hotspot mutations in KRAS/Galectin-3/p16INK4a axis regulation in colorectal cancer Supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2018 - 2018	Uncovering the role of acetate in the crosstalk between monocarboxylate transportes and oncogene signalling pathways in colorectal cancer Supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2018 - 2018	Unveil the role of actin on KRAS induced autophagy in colorectal cancer, using Caenorhabditis elegans as an "in vivo" model Supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2017 - 2017	Study the roles of human galectin-3 using the yeast saccharomyces cerevisiae and colorectal cancer cells as eukaryotic models Co-supervisor	Molecular and Environmental Biology (PhD) Universidade do Minho, Portugal
2017 - 2017	Understanding the role of oncogenic KRAS mutations in the regulation of mitochondria metabolism and Bax-mediated cell death. Co-supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2017 - 2017	Impact of immune blockade receptor PD-1 in p53wt tumor cells Co-supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2017 - 2017	Characterization of the Nuclear and Inner Neclear Membrane Proteome of Mammalian Cells Co-supervisor	Applied Biochemistry (Master) Universidade do Minho, Portugal
2016 - 2016	The role of macroH2A1 in prostate carcinogenesis Co-supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2016 - 2016	Development of a non-invasive approach for oral squamous cell carcinoma diagnosis Co-supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2016 - 2016	Researching novel proteins involved with aneuploidy Co-supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2016 - 2016	Exploring the anticancer effects of multifunctional polymer-ruthenium conjugates Supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2015/03 - 2015/09	Co-supervisor of the research grant holder Rita Francisco as part of the RuPMC research project (IF/01302/2013), funded by FCT in collaboration with the lead researcher Andreia Valente from Faculdade de Ciências da Universidade Lisboa. Co-supervisor	Universidade do Minho, Portugal
2015 - 2015	Development of new DODAX:MO:DC-Chol nanoparticles containing BRAF-siRNA for colorectal cancer therapy Supervisor	Biophysics and Bionanosystems (Master) Universidade do Minho, Portugal
2015 - 2015	Development of an improved propionibacterium for potencial use as a nutraceutical towards the prevention/treatment of colorectal cancer Supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2015 - 2015	3-Bromopiruvato uma droga anti-cancro com múltiplos alvos: das bases moleculares as futuras aplicações clinicas Supervisor	Biochemistry (Degree) Universidade do Minho, Portugal
2015 - 2015	O papel do feedback loop do oncogene KRAS-p16INK4a no cancro colorretal Supervisor	Applied Biology (Degree) Universidade do Minho, Portugal
2014 - 2015	Co-supervisor of the post-doctoral fellow Sara Cristina Sequeira Alves within the project FCT-ANR/BEX-BCM/0175/2012 in cooperation with France (University of Bordeaux 2): Phosphoregulation of Bax-dependent cell death (Phosphobax). Co-supervisor	Universidade do Minho, Portugal
2014 - 2014	3-Bromopyruvate as an anticancer agent in breast cancer cell lines: exploring the role of monocarboxylate transporters Co-supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2014 - 2014	Understanding the role of KRAS-regulated autophagy in colorectal cancer: therapeutic implications Supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2014 - 2014	Exploring galectin-3/KRASmut/p16ink4a interplay in colorectal cancer Supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2014 - 2014	The physiology and biochemistry of Methylacidiphilum fumariolicum SoIV Co-supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2014 - 2014	Effects of increasing allostatic load in stress physiology of Sea bass (Dicentrarchus labrax L.) and Sea bream (Sparus aurata L.) Co-supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2014 - 2014	Understanding the role of KRAS mutations in mitochondria regulation in the yeast model Co-supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2014 - 2014	Study of antitumor and immunomodulatory activities of wild mushroom extracts Co-supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2014 - 2014	The role of KRAS and ceramide pathways in autophagy regulation towards understanding its role in colorectal carcinoma Supervisor	Molecular and Environmental Biology (PhD) Universidade do Minho, Portugal
2013 - 2013	Current overview of the role of short-chain fatty acids in prevention or therapy of colorectal carcinoma Supervisor	Sciences - Continuous Professor Training (Master) Universidade do Minho, Portugal
2013 - 2013	The role of monocarboxylate transporters in 3-bromopyruvate effect in cancer cells Co-supervisor	Molecular and Environmental Biology (PhD) Universidade do Minho, Portugal
2013 - 2013	Impact of mutated KRAS signalling on autophagy regulation in colorectal carcinoma Supervisor	Molecular and Environmental Biology (PhD) Universidade do Minho, Portugal
2013 - 2013	Acoplamento de BSA e benzo[a]fenoxazinas a nanopartículas de CdSe/ZnS para desenvolvimento de biossensores de atividade redox Co-supervisor	Applied Biology (Degree) Universidade do Minho, Portugal
2013 - 2013	Reverting HOXA9-mediated Resistance to Temozolomide Chemotherapy in Brain Tumors Co-supervisor	Applied Biology (Degree) Universidade do Minho, Portugal
2013 - 2013	Study the role of propionate in the survival of colorectal carcinoma cells harbouring different oncogenic mutations Supervisor	Biochemistry (Degree) Universidade do Minho, Portugal
2012 - 2012	The role of KRAS mutations signalling in autophagy control in colorectal carcinomas Supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2012 - 2012	Study the Role of Ceramide in Acetic Acid Induced Cell Death in Colorectal Carcinoma Cell Lines Supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2012 - 2012	Study the role of RAF-1 in MAPK signaling in thyroid cancer cells Supervisor	Biotechnology for the Health Sciences (Master) Universidade de Trás-os-Montes e Alto Douro, Portugal
2012 - 2012	The role of ceramide in response to acetic acid induced cell death in colorectal carcinoma derived cell lines Supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2012 - 2012	Somitogenesis molecular clock Co-supervisor	Applied Biology (Degree) Universidade do Minho, Portugal
2012 - 2012	Role of embryonic macrophages in lung vascular development Co-supervisor	Applied Biology (Degree) Universidade do Minho, Portugal
2012 - 2012	O efeito do 3-bromopiruvato (3BP) como inibidor metabólico no tratamento de cancro Co-supervisor	Applied Biology (Degree) Universidade do Minho, Portugal
2012 - 2012	Protein Microspheres as Templates for anti-cancer drugs delivery Supervisor	Applied Biology (Degree) Universidade do Minho, Portugal
2011 - 2011	Unraveling the mechanisms involved in acetate induced apoptosis in colorectal cancer Supervisor	Pathology and Molecular Genetics (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2011	Development of folate-targeted liposomes for rheumatoid arthritis therapy Supervisor	Molecular and Environmental Biology (PhD) Universidade do Minho, Portugal
2011 - 2011	Role of monocarboxylate transporters in colorectal carcinoma Co-supervisor	Health Sciences (Master) Universidade do Minho, Portugal
2011 - 2011	Influência da sobre-expressão da HOXA9 na resposta celular à quimioterapia Supervisor	Applied Biology (Degree) Universidade do Minho, Portugal
2011 - 2011	Regulação da Expressão do Receptor de Androgénios na Próstata de Rato Supervisor	Applied Biology (Degree) Universidade do Minho, Portugal
2010 - 2010	Study the response to acetate in colorectal carcinoma cells harbouring different genetic background: the role of the lysosome Supervisor	Biotechnology for the Health Sciences (Master) Universidade de Trás-os-Montes e Alto Douro, Portugal
2010 - 2010	Study the effect of synthetic Tamoxifen-like compounds in survival of cancer cells Co-supervisor	Biotechnology for the Health Sciences (Master) Universidade de Trás-os-Montes e Alto Douro, Portugal
2010 - 2010	Caracterização molecular da Displasia Arritmogénica Ventricular Direita em pacientes com suspeita clínica da doença: uma abordagem de diagnostico molecular mais rápida e económica Supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2010 - 2010	Estudo anatomopatológico em cérebros de ratinhos transgénicos para a Doença de Machado-Joseph Supervisor	Applied Biology (Degree) Universidade do Minho, Portugal
2010 - 2010	Bioactive anticancer compounds produced by marine sponges. What about Portuguese reality? Co-supervisor	Biology/Geology (Degree) Universidade do Minho, Portugal
2009 - 2009	Autophagy regulation by RAS towards understanding its role in human cancer Supervisor	Molecular Genetics (Master) Universidade do Minho, Portugal
2009 - 2009	Caracterização mutacional do gene ATP1A2em doentes com Enxaqueca Hemiplégica Familiar (FHM) Supervisor	Applied Biology (Degree) Universidade do Minho, Portugal
2008 - 2008	Optimização da separação e identificação de glicoproteínas de soro humano de indivíduos com cancro Supervisor	Applied Biology (Degree) Universidade do Minho, Portugal
2008 - 2008	The role of autophagy in colorectal carcinomas. The cross-talk of RAS and Beclin-1 pathways Supervisor	Applied Biology (Degree) Universidade do Minho, Portugal
2008 - 2008	Capillary treatments with oligonucleotides Supervisor	Applied Biology (Degree) Universidade do Minho, Portugal
2005 - 2007	Biological role of BRAF activation in colon carcinogenesis. STI-571/Gleevec as a therapeutic agent Supervisor	Universidade do Minho, Portugal
2005 - 2007	Potential mechanisms of tolerance to wild-type p53 in human tumours using thyroid as a prototype Supervisor	Universidade do Minho, Portugal
2004 - 2005	Biological role of BRAF activation in colon carcinogenesis. STI-571/Gleevec as a therapeutic agent Supervisor
2003 - 2004	Potential mechanisms of tolerance to wild-type p53 in human tumours using thyroid as a prototype Co-supervisor	Universidade do Minho, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2013 - Current	Organizer and coordinator of the Advanced course Cancer therapy: from basic research to clinic, Departamento de Biologia da Universidade do Minho. (2013) Other (President of the Organising Committee)	Universidade do Minho, Portugal
2022/09/28 - 2022/09/30	Member of the Organising Committee of the 6th Cancer World Congress, Lisbon, Portugal. (2022/09/28 - 2022/09/30) Congress (Member of the Organising Committee)
2022/06/30 - 2022/07/01	Member of the Organising Committee of the Conference "5th ASPIC International Congress" (2022/06/30) Conference (Member of the Organising Committee)	Associação Portuguesa de Investigação em Cancro, Portugal
2021 - 2021	Member of the Organizing Committee of the II ASPIC-ASEICA International Meeting Current Trends in Precision Medicine in Cancer, online event (2021) Meeting (Member of the Organising Committee)	Associação Portuguesa de Investigação em Cancro (ASPIC), Portugal
2020/03/02 - 2020/03/04	Member of the Organizing Committee of the EACR-AACR-ASPIC Conference: Tumor Microenvironment, Lisbon, Portugal. (2020) Conference	Associação Portuguesa de Investigação em Cancro (ASPIC), Portugal
2019/12/19 - 2019/12/20	- Member of the organizing committee of the I Symposium on Biophysics and Bionanosystems, which marked the 10th edition of the Master's Degree in Biophysics and Bionanosystems. Braga. (2019 - 2019) Symposium (Member of the Organising Committee)	Universidade do Minho, Portugal
2019/10/17 - 2019/10/19	President of the organization of the international congress ISCAM 2019 - 6th Annual Meeting, Bom Jesus de Braga, Braga. (2019/10/17 - 2019/10/19) Congress (President of the Organising Committee)	International Society of Cancer Metabolism, Portugal
2018/10/26 - 2018/10/26	Member of the Organizing Committee of the ASPIC Conference - Colorectal cancer in Portugal: from research to prevention and treatment, Auditorium Mariano Gago of i3S, Porto. (2018/10/26 - 2018/10/26) Conference (Member of the Organising Committee)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/04/28 - 2016/04/29	- Member of the organizing committee and poster session chair of the 2nd International Congress of Associação Portuguesa de Investigação em Cancro (ASPIC), April 28-29, 2016, IPO, Porto, Portugal (2016 - 2016) Congress (Member of the Organising Committee)	Associação Portuguesa de Investigação em Cancro (ASPIC), Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2022/12/19	"Unravelling the role of cell metabolism in the molecular mechanisms of resistance in cancer. Encapsulation of glycolytic inhibitors in nanoparticles to increase their release in a lung cancer model." (Thesis) Main arguer	Andrea Teixeira da Cunha (PhD) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2022/11/18	Main evaluator of the probationary year report and the development of the work leading to the Doctoral Thesis of Master Sofia Manuela Moreira Dias, with the title: "3D-CRCol: 3D ColoRectal Cancer spheroid model with a 3D cOLon model for drug and nanoparticle safety and efficacy screening"	Sofia Manuela Moreira Dias (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/06/17	Main evaluator of the report of the probationary year and of the development of the work leading to the PhD Thesis of Master Eleonora Secomandi, with the title: "High Expression of Lysosomal Cathepsin D Inhibits Neuroblastoma Cell Growth, Migration and Invasion, and Confers Better Prognosis in Neuroblastoma Patients"	Eleonora Secomandi (PhD) Università degli Studi del Piemonte Orientale Amedeo Avogadro - Sede di Novara, Italy
2021/06/07	Panel Member of the Doctoral Thesis of Diana Isabel Pereira Guimarães: "Development of liposomal formulations for therapeutic applications". PhD in Chemical and Biological Engineering. (Thesis) Arguer	Diana Isabel Pereira Guimarães (PhD) Universidade do Minho Escola de Engenharia, Portugal
2021/06/06	Panel Member of the Doctoral Thesis of Cristiana Filipa Chaves Costa: "Development of new strategies to model the shape of hair from the follicle". PhD in Chemical and Biological Engineering. (Thesis) Arguer	Cristiana Filipa Chaves Costa (PhD) Universidade do Minho Escola de Engenharia, Portugal
2021	Effect of the microenvironment on alternative splicing in colorectal cells (Thesis) Main arguer	Joana Filipa de Sousa Pereira (PhD) Universidade de Lisboa Faculdade de Ciências, Portugal
2021	m6ACODE: Deciphering the hidden message in m6A methylation in Gastric Cancer (Thesis) Main arguer	Diana Cristina Silva Ferreira de título (Master) Universidade do Porto Faculdade de Medicina, Portugal
2021	Deciphering the functional role of KRAS-induced SUSD2 downregulation in colorectal cancer (Thesis) Main arguer	Diogo Rafael Dias Coelho (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020	Studying the combined effect of Pirfenidone and Vinorelbine in lung and breast cancer cell lines (Thesis) Main arguer	Catarina Teixeira Antunes (Master) Universidade do Porto Faculdade de Medicina, Portugal
2020	The Immunomodulation Potential of Pancreatic Cancer Exosomes (Thesis) Main arguer	Sofia Torres Ferrando Alves Quintas (Master) Universidade do Porto Faculdade de Medicina, Portugal
2020	Melanoma in zebrafish disregards Telomere Maintenance Mechanisms (Thesis) Main arguer	Joana Nabais (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020	New Biomarkers Development, Validation and Application in Bladder Cancer (Thesis) Main arguer	Rui Pedro Monteiro Batista (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019	The role of RKIP in head and neck cancer (Thesis) Main arguer	Patricia Sofia Vaz da Cunha (Master) Universidade do Minho Escola de Medicina, Portugal
2019	Serum VEGF levels in colorectal carcinoma : its relationship with clinicopathological characteristics and disease outcome (Thesis) Main arguer	Inês da Cunha Macedo Conde (Master) Universidade do Minho Escola de Medicina, Portugal
2019	Telomere Biology of Cutaneous T-cell Lymphomas (Thesis) Main arguer	Joana Ropio (PhD) Université de Bordeaux, France
2019	Regulation of glucose uptake in mammalian cells by protein phosphorylation networks (Thesis) Main arguer	Andreia Filipa Almeida Henriques (PhD) Universidade de Lisboa Faculdade de Ciências, Portugal
2018	TERT promoter mutations in cancer: from cell immortalization to invasion? (Thesis) Main arguer	Ana Cristina Afonseca Pestana (PhD) Universidade do Porto Faculdade de Medicina, Portugal
2018	Extracellular Matrix-Glycan Dynamics in Gastric Cancer (Thesis) Main arguer	Mariana Cristina Nogueira Ferreira (Master) Universidade do Minho, Portugal
2018	Evaluation of the role of LRP1B in the response of human ovarian cancer cells to liposomal doxorubicin (Thesis) Main arguer	Inês de Andrade Matos Gonçalves Saraiva (Master) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018	Exploring characteristics of atypical cancer cells from the HT29 human colonic adenocarcinoma cell line (Thesis) Main arguer	Maria Ine^s de Castro Silva (Master) Universidade do Porto Faculdade de Medicina, Portugal
2018	Urothelial Bladder Cancer and Chemoresistence: Role of Energetic Metabolism Reprogramming (Thesis) Main arguer	Joana Moutinho Lopes Martins (Master) Universidade do Minho Escola de Medicina, Portugal
2018	SPINT2 expression in lung cancer (Thesis) Main arguer	Bruno Daniel Oliveira Peixoto (Master) Universidade do Minho Escola de Medicina, Portugal
2017	Role of Mitochondrial Dynamics in Hu¨rthle Cell Tumors: Coupling, Uncoupling and Fission (Thesis) Main arguer	Liliana Pereira Santos (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017	Evidence for a role of autophagy in the release of extracellular vesicles by tumour cells: possible implications for drug resistant cells with impaired autophagy (Thesis) Main arguer	Andre´ Figueiredo Pina (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017	Delivery of methotrexate using fucoidan/chitosan pH sensitive nanoparticles (Thesis) Main arguer	Ana Isabel Ferreira Barbosa (Master) Universidade do Porto Faculdade de Farmácia, Portugal
2015	Joint Modelling of Longitudinal and Survival Data on Breast Cancer (Thesis) Main arguer	Ana Isabel Coelho Borges (PhD) Universidade do Minho Escola de Ciências, Portugal
2013	First molecular and biochemical characterization of the extracellular matrix of Saccharomyces cerevisiae (Thesis) Main arguer	Fábio Luís Silva Faria Oliveira (PhD) Universidade do Minho Escola de Ciências, Portugal
2013	Role of Monocarboxylate transporter in lung development and lung cancer (Thesis) Main arguer	Sara da Costa Granja (PhD) Universidade do Minho Escola de Medicina, Portugal
2012	Unravelling the function and regulation of human NLZ1 and COG8/PDF (Thesis) Main arguer	Isabel Pereira de Castro (PhD) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2011	Functional characterization of purified vacuoles and evaluation of their role in yeast apoptosis induced by acetic acid (Thesis) Main arguer	Andreia Doris (Master) Universidade do Minho, Portugal
2010	Study of the role of monocarboxylate transporters in colorectal carcinoma (Thesis) Main arguer	Helena Pereira (Master) Universidade do Minho, Portugal
2010	The importance of H-RAS 81T-C polymorphism in cellular behaviour (Thesis) Main arguer	Mariline Mendes Silva (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009	Nanotecnología en Biomedicina: evaluación de la biocompatibilidad de nanoestructuras y su aplicación en el desarrollo de vacunas y biosensores (Thesis) Main arguer	Belén Díaz Freitas (PhD) Universidade de Vigo, Spain
2008	Caracterização da P149: uma nova proteína humana que interage com membros da via Wnt (Thesis) Main arguer	Isabel Pereira Castro (Master) Universidade do Porto Faculdade de Medicina, Portugal

Ad Hoc journal article review

	Journal title (ISSN)	Publisher
2021 - Current	Cancers	MDPI
2018 - Current	Cells	MDPI
2017 - Current	Frontiers in Nutrition	Frontiers
2022 - 2022	International Journal of Molecular Sciences	MDPI
2020 - 2022	Frontiers in Oncology - Cancer Metabolism	Frontiers
2021 - 2021	Food and Function	The Royal Society of Chemistry
2021 - 2021	Journal of Experimental & Clinical Cancer Research	BMC
2021 - 2021	Frontiers in Cell and Developmental Biology	Frontiers
2021 - 2021	Scientific reports	Nature
2021 - 2021	Seminars in Cancer Biology	Elsevier
2017 - 2020	Frontiers in Nutrition	Frontiers
2019 - 2019	Ageing	Oxford Academic
2018 - 2018	International Journal of Molecular Sciences (1422-0067)	MDPI AG
2018 - 2018	Biochimie	Elsevier
2018 - 2018	RSC Advances (2046-2069)	The Royal Society of Chemistry
2018 - 2018	Anti-Cancer Agents in Medicinal Chemistry (1871-5206)	Bentham Science
2017 - 2017	Food & Function (2042-650X)	The Royal Society of Chemistry
2017 - 2017	Journal of Experimental & Clinical Cancer Research	Springer Nature
2017 - 2017	Molecular Diagnostics and Therapeutics	Frontiers
2016 - 2017	Cell Death and Disease	Springer Nature
2016 - 2016	PLoS ONE (1932-6203)	Public Library of Science
2015 - 2016	Oncotarget	Oncotarget
2013 - 2016	Carcinogenesis	Oxford Academic
2012 - 2015	Cancer Research Journal	Science Publishing Group
2014 - 2014	Journal of Clinical Endocrinology and Metabolism	Oxford Academic
2014 - 2014	BMC Cancer	Springer
2014 - 2014	Frontiers in Molecular Biosciences- Molecular Diagnostics (2327-2724)	Science Publishing Group
2012 - 2014	International Journal of Nutrition and Food Sciences (2327-2694)	Science Publishing Group
2013 - 2013	European Journal of Human Genetics (1476-5438)	Springer Science and Business Media LLC
2013 - 2013	Biological Trace Element Research	Springer
2012 - 2012	Science Journal of Clinical Medicine (2327-2724)	Science Publishing Group
2010 - 2010	BMC Cancer	Springer
2008 - 2008	BMC Cancer (1471-2407)	Springer (Biomed Central Ltd.)
2008 - 2008	Journal of Pathology	Wiley Online Library
2007 - 2007	Oncogene (0950-9232)	Springer Science and Business Media LLC
2006 - 2007	Virchows Archiv (1432-2307)	Springer-Verlag
2006 - 2006	Molecular and Celular Biology	ASM Journals
2006 - 2006	Endocrine Pathology	Springer
2006 - 2006	Molecular & Cellular Biology (2372-3556)	Landes Bioscience

Consulting

	Activity description	Institution / Organization
2013 - 2020	Unpaid consultancy activity as the Responsible Pharmacist (professional license no. 10931) at INFARMED for the import, maintenance and conservation of Narcotics / Psychotropic Substances as part of the project: "Prenatal stress and reward deficits: searching for the neurobiological underpinnings", which is taking place at the School of Medicine, ICVS/3Bs. The activity schedule has been set at 1 hour per month.	Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP Centro de Documentação Técnica e Científica, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2016 - Current	Guest lecturer in the Postgraduate Course ONCOBIOLOGY, Doctoral Program in Biological Sciences Applied to Health, Department of Sciences, IUCS Instituto Universitário de Ciências da Saúde, CESPU with the title: Cancer definition and Hallmarks; Gandra, Paredes.	Programa Doutoral em Ciências Biológicas Aplicadas à Saúde (Pós-Graduação)	Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2009/09 - Current	Career Assistant Professor of the Departamento de Biologia da Universidade do Minho.
2003 - Current	Guest lecturer in the Oncobiology module of the PhD Program GABBA (Programa Graduado em Áreas de Biologia Básica e Aplicada)	Oncobiology (Doutoramento)	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2022/04/25 - 2022/05/06	Organiser and coordinator of the advanced course "Cancer therapy: from basic research to clinic"	(Outros)	Universidade do Minho, Portugal
2021/11/02 - 2021/11/02	Lecturer in the Course Unit: MOLECULAR BASES OF CANCER AND THERAPEUTIC PRINCIPLES, 2nd year Integrated Master's Degree in Medicine, entitled "How yeast and cancer cells link-up to study colorectal cancer", UMinho, School of Medicine, Braga.	Mestrado Integrado em Medicina (Mestrado)	Universidade do Minho Escola de Medicina, Portugal
2013 - 2014	Guest lecturer for the postgraduate course: "Fundamentals in Genetics, Development and Neoplasia" entitled: "Cell Signaling: Signal Transduction in Cancer" ICVS, Escola de Ciências da Saúde, Universidade do Minho.	Fundamentals in Genetics, Development and Neoplasia (Pós-Graduação)	Universidade do Minho Escola de Medicina, Portugal
2013/07/05 - 2013/07/05	- Guest lecturer in the postgraduate course : "Pharmacological Development: from Organic Synthesis to Clinical Trials", entitled: ¿"New therapeutic approaches for colorectal cancer: the role of small chain fatty acids and oncogene KRAS." ¿ICVS.	Pharmacological Development: from Organic Synthesis to Clinical Trials (Pós-Graduação)	Universidade do Minho Escola de Medicina, Portugal Laboratório Associado ICVS 3B's, Portugal
2013/07/05 - 2013/07/05	Guest lecturer in the Postgraduate course: "Pharmacological Development: from Organic Synthesis to Clinical Trials", entitled: ¿New therapeutic approaches for colorectal cancer: the role of small chain fatty acids and oncogene KRAS. ¿ICVS	Fundamentals of Genetics, Development and Neoplasia (Pós-Graduação)	Universidade do Minho Escola de Ciências, Portugal Laboratório Associado ICVS 3B's, Portugal
2007 - 2009	Professor of Cell Biology of the Bachelor in Biochemistry and of Bioenergetics and Metabolism of the Bachelor in Biology/Geology. Teacher of practical classes in Animal Physiology and Bioenergetics and Metabolism of the Bachelor in Applied Biology and of Molecular Biology of the Bachelor in Biology/Geology.	Bachelor in Biochemistry, Bachelor in Biology/Geology, Bachelor in Applied Biology (Licenciatura)	Universidade do Minho, Portugal
2008/06/26 - 2008/07/01	Coordinator of the course Genetics and Molecular Biology II: From the Gene to the Cell.... Training course accredited by the Training Center of the Order of Biologists. Departamento de Biologia, Universidade do Minho.	(Pós-Graduação)	Universidade do Minho Departamento de Biologia, Portugal
2004 - 2007	Lecturer in Pharmacology for the Bachelor in Nursing, Toxicology for the Bachelor in Pharmacy Technician and Pharmacotoxicology for the Bachelor inClinical Analysis Technician.	Nursing (Licenciatura)	Instituto Superior de Saúde, Portugal
2006 - 2006	Lecturer in the postgraduation course "Introduction to Molecular Medicine and Cancer" organized by IPATIMUP.	(Pós-Graduação)	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2004 - 2004	Guest lecturer in the Molecular Pathology module of the postgraduate course in Biomedicine at Faculdade de Medicina da Universidade de Coimbra.		Universidade de Coimbra, Portugal
1996 - 1997	Monitor of laboratory classes in Molecular Genetics and Immunology, taught by Professor Anabela Cordeiro da Silva, in Departamento de Bioquímica da Faculdade de Farmácia da Universidade do Porto.	(Mestrado)	Universidade do Porto Faculdade de Farmácia, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2024/01 - 2024/06	Research Project evaluator for the “French National Cancer Institute (INCa) - PLBIO 2024” Evaluator		Institut National du Cancer
2021/10/14 - 2021/10/15	- Judging Panel and selection of abstracts to be presented as oral communications at the II ASPIC-ASEICA International Meeting Current Trends in Precision Medicine in Cancer, online event. Coordinator	Associação Portuguesa de Investigação em Cancro (ASPIC), Portugal
2021/10/14 - 2021/10/15	- Judging panel for the best oral presentations at the II ASPIC-ASEICA International Meeting Current Trends in Precision Medicine in Cancer, online event. Coordinator	Associação Portuguesa de Investigação em Cancro (ASPIC), Portugal
2016 - 2016	Evaluation and selection of abstracts to be presented as oral or poster presentations at the 2nd International Congress of Associação Portuguesa de Investigação em Cancro (ASPIC). Evaluator	Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2016 - 2016	Evaluation Jury of the prizes for the best oral communications presented at the 2nd International Congress of Associação Portuguesa de Investigação em Cancro (ASPIC), IPO, Porto.	Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2015/09 - 2015/11	Jury at the contest "Eureka! - Concurso Nacional de Ciência", which took place for the first time between September and November 2015. The main aim of the project is to present and discuss scientific topics, based on a creative, innovative and entrepreneurial spirit. It is aimed at all students enrolled in a higher education institution in Portugal (university and polytechnic). Evaluator
2014 - 2014	Evaluation jury of projects of Fonds National de la Recherche (FNR) Award for Outstanding Scientific Publications
2014 - 2014	Competition for Research Projects Gabinete de Apoio à Investigação (GAI), to promote an internal contest to promote a basic and clinical investigation to be carried out within FMUC. The jury panel was published, simultaneously with the awarded, by all the scientific community of FMUC and published at the GAI website (http://www.uc.pt/fmuc/gai). Evaluator	Universidade de Coimbra Faculdade de Medicina, Portugal
2012 - 2012	Reviewer and evaluator of abstracts to be accepted at the I Simposio Internacional de Enseñanza de las Ciencias http://webs.uvigo.es/isiec2012/ Evaluator	Universidade de Vigo, Spain
2009 - 2009	Evaluating Jury of projects for PhD grants in the Program Aides à la Formation-Recherche (AFR) of the Fonds National de la Recherche (FNR) from Luxembourg.

Interview (newspaper / magazine)

	Activity description	Newspaper / Forum
2016/10/09	News item in Observador on the Nobel Prize in Medicine: ¿Como o Nobel da Medicina chegou a uma sala de aula portuguesa¿ on the subject of autophagy in colorectal cancer, an area of research in which he has been working since 2008.	Observador

Journal scientific committee

	Journal title (ISSN)	Publisher
2018 - Current	Guest editor da revista “Cells” no “Special Issue”: "Role of KRAS in Colorectal Cancer", since 2018.	MDPI
2017 - Current	Associate guest editor for Clinical Nutrition in the journal Frontiers in Nutrition	Frontiers
2017 - Current	Review Editor for Molecular Diagnostics and Therapeutics in Frontiers in Molecular Biosciences Journal, desde 2017	Frontiers
2020 - 2022	Guest Associate Editor for Cancer Metabolism Frontiers in ONCOLOGY, TOPIC Editor on the Research Topic: “Annual Meeting of the International Society of Cancer Metabolism (ISCaM)- Cancer Metabolic Rewiring: Mapping the Road to Clinical Translation”, 2020-2022.	Frontiers
2017 - 2018	Topic editor of “Cancer Metabolism and Nutrition: Impact in Tumor Biology and Therapy” at Frontiers in Nutrition journal. 2017-2018.	Frontiers
2014 - 2018	Editorial Board as Review Editor of Frontiers in Molecular Biosciences- Molecular Diagnostics (specialty section of Frontiers in Molecular Biosciences), 2014-2018.	Frontiers
2012 - 2016	Member of the editorial board of the Science Publishing Group in the journal Science Journal of Clinical Medicine.	Science Publishing Group

Distinctions

Award

2022	"ASPIC Patients' Advocacy Award" Associação Portuguesa de Investigação em Cancro (ASPIC), Portugal
2020	Prize for the best poster in the conference Cancer Biology: from basic to translational research Liga Portuguesa Contra o Cancro, Portugal
2015	"SBBq Award" for the best poster presented during the 44th Annual Meeting of Brazilian Society for Biochemistry and Molecular Biology and 23rd International Congress of International Union of Biochemistry and Molecular Biology Sociedade Brasileira de Bioquímica e Biologia Molecular, Brazil
2014	Award for the best Poster at the "II Symposium of the PhD Programme on Molecular and Environmental Biology”, with the title: The cytotoxicity of 3-Bromopyruvate in breast cancer cells depends on extracellular pH, João Azevedo-Silva
2013	Award for the best scientific work at the Conference - Faraday Discussion 166: Self-Assembly of Biopolymers - University of Bristol ,UK: Eugénia Nogueira, Ana Preto, Artur Cavaco-Paulo. Royal Society of Chemistry, United Kingdom
2012	Tribute to research groups in Portugal that investigate breast cancer and publish in indexed journals
2004	Best Scientific Work 2004 award for PhD thesis Centro de Genética Médica Doutor Jacinto Magalhães, Portugal
2003	Award for the Best Communication in Biomedical Sciences Sociedade Portuguesa de Ciências Farmacêuticas, Portugal

Other distinction

2018	Bolsa de sabática- Universidade de Vigo, CINBIO. INSTITUIÇÃO DE DESTINO: UNIVERSIDADE DE VIGO DEPARTAMENTO: CENTRO DE INVESTIGACIÓNS BIOMÉDICAS (CINBIO).