Personal identification

Full name

Maria da Glória Correia da Silva Queiroz

Date of birth

1968/09/27

Citation names

• Glória Queiroz; Queiroz G; Queiróz G; Gloria Queiroz

Author identifiers

Ciência ID

C911-A0C1-C3F2

ORCID iD

0000-0001-9187-0922

AuthenticusID

R-000-AXK

Scopus Author Id

6603693961

Email addresses

• gloria@ff.up.pt (Professional)

Telephones

Telephone

• 220428604 Ext.: 8604 (Professional)

Addresses

• Faculdade de Farmácia da Universidade do Porto. Rua Jorge Viterbo Ferreira nº228, 4050-313, PORTO, Porto, Portugal (Professional)

Knowledge fields

• Medical and Health Sciences - Health Sciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
French	Intermediate (B1)	Intermediate (B1)	Beginner (A1)	Intermediate (B1)
German	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)

	Degree	Classification
1999/09/14 Concluded	Doutoramento em Farmacologia (Doutoramento) Universidade do Porto Faculdade de Farmácia, Portugal "Glutamate-evoked release of ATP from cortical astroglial cells" (THESIS/DISSERTATION)	Aprovado por unanimidade
1992 Concluded	Licenciatura em Ciências Farmacêuticas - Opção C (Análises Quimico-Biológicas) (Licenciatura) Universidade do Porto Faculdade de Farmácia, Portugal	15

Teaching in Higher Education

	Category Host institution	Employer
2012 - Current	Associate Professor (University Teacher)	Universidade do Porto, Portugal
	Universidade do Porto Faculdade de Farmácia, Portugal

Positions / Appointments

	Category Host institution	Employer
2022 - 2024	Membro do Conselho científico	Universidade do Porto Faculdade de Farmácia, Portugal
	Universidade do Porto Faculdade de Farmácia, Portugal
2018 - 2022	Membro do Conselho de Representantes	Universidade do Porto Faculdade de Farmácia, Portugal
	Universidade do Porto Faculdade de Farmácia, Portugal
2014 - 2018	Membro do Conselho de Representantes	Universidade do Porto Faculdade de Farmácia, Portugal
	Universidade do Porto Faculdade de Farmácia, Portugal
2011 - 2018	Membro da Comissão de Coordenação dos Estágios	Universidade do Porto Faculdade de Farmácia, Portugal
	Universidade do Porto Faculdade de Farmácia, Portugal
2010 - 2016	Membro do Conselho Cientifico	Universidade do Porto Faculdade de Farmácia, Portugal
	Universidade do Porto Faculdade de Farmácia, Portugal
2010 - 2015	Responsável do Laboratório de Farmacologia	Universidade do Porto Faculdade de Farmácia, Portugal
	Universidade do Porto Faculdade de Farmácia, Portugal
1999 - 2010	Membro do Conselho científico	Universidade do Porto Faculdade de Farmácia, Portugal
	Universidade do Porto Faculdade de Farmácia, Portugal
2007 - 2008	Responsável do Laboratório de Farmacologia	Universidade do Porto Faculdade de Farmácia, Portugal
	Universidade do Porto Faculdade de Farmácia, Portugal
2002 - 2004	Membro da Assembleia de Representantes	Universidade do Porto Faculdade de Farmácia, Portugal
	Universidade do Porto Faculdade de Farmácia, Portugal

Grant

	Designation	Funders
2011 - 2014	Modulação purinérgica da comunicação astrócito-micróglia na astrogliose PTDC/SAU-TOX/115597/2009 115597PRJ Principal investigator Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal	Fundação para a Ciência e Tecnologia
2009 - 2010	Purinergic regulation of noradrenaline levels in cortical synapses PPII - CORTICAL Principal investigator Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal	Reitoria da Universidade do Porto Concluded
2006 - 2010	Papel dos recetores P2 na comunicação neuronal e neurónio-astrócito POCTI/SAU-FCF/60714/2004 Principal investigator Universidade do Porto Faculdade de Farmácia, Portugal	Associação para a Inovação e Desenvolvimento da FCT Concluded
2007 - 2008	Using yeast-based functional assays for the study of p53 signalling pathway, pharmacological screening and molecular characerization of small-molecules targetting p53 function IPG 05/2007 Researcher Universidade do Porto Faculdade de Farmácia, Portugal	Reitoria da Universidade do Porto Concluded
2004 - 2008	Libertação neuronal de nucleotidases e o seu papel na modulação purinérgica da transmissão sináptica. POCTI/SAU-FCF/60714/2004 Researcher Universidade do Porto Faculdade de Farmácia, Portugal	Associação para a Inovação e Desenvolvimento da FCT Concluded
2004 - 2008	PAPEL DOS RECEPTORES P2 NA COMUNICAÇÃO NEURONAL E NEURÓNIO-ASTRÓCITO POCI/SAU-FCF/60714/2004	Fundação para a Ciência e Tecnologia

Contract

	Designation	Funders
2019/01/01 - 2019/12/31	Centro de Investigação Farmacológica e Inovação Medicamentosa UID/BIM/04308/2019 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2012/12/31	Strategic Project - LA 6 - 2011-2012 PEst-C/EQB/LA0006/2011 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011 - 2012	Regulation by microglia of nucleotide induced astrogliosis. Mechanisms involved. PPII_MICROGLIA Principal investigator Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal	Reitoria da Universidade do Porto Concluded
2011 - 2012	Effect of adenosine on cell proliferation and production of extracellular matrix and angiotensin II in rat glomeral mesangial cells exposed to high glucose. PPII_EXTRACELULAR Researcher Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal	Universidade do Porto Concluded

Publications

Book chapter	Gonçalves, J.; Queiroz, G.. "Presynaptic adenosine and P2Y receptors". 2008. Published • 10.1007/978-3-540-74805-2-11
Conference abstract	Clara Quintas; Glória Queiroz; Rui Silva; Jorge Gonçalves. "Influence of Microglia PPARgama Activation In the Control of Purinergic-Mediated Astroglial Proliferation.". Paper presented in XIV European Meeting on Glial Cells in Health and Disease., Porto, 2019. Published Queiroz, G; Quintas, C; Goncalves, J. "LPS-activated microglia overexpress P2Y(6) receptors that mediate an inhibition of astroglial proliferation by inducing no mediated apoptosis". 2012. Pinho, D; Quintas, C; Sardo, F; Queiroz, G. "Glial P2Y receptors contribute to the regulation of noradrenergic transmission in the rat brain cortex". 2012. Quintas, C; Magalhaes, J; Goncalves, J; Queiroz, G. "Inhibition of astroglia proliferation by nucleotides: contribution of P1 receptors". 2010. Queiroz, G; Quintas, C; Magalhaes, J; Goncalves, J. "Microglia P2Y6 receptors mediate an inhibition of astroglia proliferation in cultures of rat brain cortex". 2010. Santos, JM; Queiroz, G; Appell, HJ; Duarte, JA. "The Effect Of Age On Contraction-induced Glucose Uptake, Glut1 And Glut4 Expression In Skeletal Muscle". 2010. 10.1249/01.mss.0000386193.29818.4c Glória Queiróz. "P2Y6 receptors inhibit astroglia proliferation in cultures with activated microglia.". 2009. 10.3389/conf.neuro.01.2009.11.055 Glória Queiróz; Queiroz, G; Gonclaves, J. "PRESYNAPTIC ADENOSINE AND P2Y RECEPTORS AND THEIR ROLE ON MODULATION OF NEUROTRANSMITTER RELEASE". Paper presented in 36th International Congress of Physiological Sciences. IUPHAR Joint Symposium on Cotransmission and Presynaptic Receptors., Kyoto, 2009. Published Julia M Santos; Sandra B Ribeiro; Gloria Queiroz; Jose A Duarte; Clara Quintas; Diogo Pestana; Sonia Fraga; et al. "Influence of A1 and P2 receptor-activation on angiotensin II mediated facilitation of noradrenaline release in the rat mesenteric vessels.". 2008. 10.1007/s11302-008-9116-0 Glória Queiróz. "Pharmacological profile of P2Y receptors involved in feedback inhibition of noradrenaline release in sympathetic innervated tissues.". 2006. Goncalves, J; Queiroz, G; Fresco, P; Diniz, C. "Interaction of facilitatory adenosine receptors and presynaptic-inhibitory receptors on noradrenaline release". 2004. Talaia, C; Queiroz, G; Goncalves, J. "Mechanisms involved on cross-talk between G(i/o)-protein coupled receptors and presynaptic facilitatory receptors that modulate noradrenaline release". 2004. Queiroz, G; Goncalves, J. "Opposite influence of alpha(2)-autoreceptor activation on the A(1)- and A(2A)-adenosine receptor: Modulation of noradrenaline release in isolated epididymal portion of rat vas deferens". 2002. Queiroz, G; Mluvkova, P; Talaia, C; Goncalves, J. "P-2Y and P-2X receptors mediate an opposite modulation of noradrenaline release in the rat vas deferens". 2001. Diniz, C; Leal, S; Queiroz, G; Goncalves, J. "Regional differences on the adenosine-receptor-mediated modulation of adrenergic and purinergic contractions in the rat vas deferens". 2001. 10.1016/s0014-2999(02)02926-6 Diniz, C; Leal, S; Queiroz, G; Goncalves, J. "A differential distribution of adenosine receptors along the rat vas deferens revealed by immunohistochemistry". 2001. Queiroz, G; Diniz, C; Goncalves, J. "Interactions between alpha(2)-autoreceptors and the A(1) and A(2A)-adenosine receptors on the modulation of noradrenaline release in the rat vas deferens". 2001. Queiroz, G; Diniz, C; Fresco, P; Goncalves, J. "Facilitation by adenosine of noradrenaline release in rat isolated vas deferens is prevented by blockade of alpha(2)-autoreceptors". 1999. Diniz, C; Fresco, P; Queiroz, G; Goncalves, J. "Influence of alpha(2)-autoreceptor blockade on the A(2A)-mediated facilitation of noradrenaline release in rat isolated tail artery". 1999. Queiroz G; Meyer DK; Meyer A; Starke K; von Kügelgen I. "A study of the mechanism of the release of ATP from rat cortical astroglial cells evoked by activation of glutamate receptors.". Paper presented in XI Congresso Nacional de Bioquímica., Tomar, 1998.
Journal article	Clara Quintas; J.Gonçalves; Glória Queiroz. "Involvement of P2Y1, P2Y6, A1 and A2A Receptors in the Purinergic Inhibition of NMDA-Evoked Noradrenaline Release in the Rat Brain Cortex". Cells 12 13 (2023): 1690-1690. http://dx.doi.org/10.3390/cells12131690. 10.3390/cells12131690 Gonçalves, Jorge Manuel Moreira; Quintas, Clara; Silva, Dany; Queiroz, Glória; Fresco, Paula. "Unexpected Therapeutic Effects of Common Drugs: Lessons from 15 Years of Drug Repurposing". Revista Portuguesa de Farmacoterapia 11 4 (2020): 177-185. http://revista.farmacoterapia.pt/index.php/rpf/article/view/265. Published • 10.25756/rpf.v11i4.228 Quintas, C; Vale, N; Goncalves, J; Queiroz, G. "Microglia P2Y(13) Receptors Prevent Astrocyte Proliferation Mediated by P2Y(1) Receptors". FRONTIERS IN PHARMACOLOGY 9 418 (2018): 1-12. https://doi.org/10.3389/fphar.2018.00418. Published • 10.3389/fphar.2018.00418 Soares J; Raimundo L; Pereira NA; Monteiro Â; Gomes S; Bessa C; Pereira C; et al. "Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule.". ONCOTARGET 7 (2016): 4326-4343. https://doi.org/10.18632/oncotarget.6775. Published • 10.18632/oncotarget.6775 Leão M; Soares J; Gomes S; Raimundo L; Ramos H; Bessa C; Queiroz G; et al. "Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53-MDM2 interaction.". LIFE SCIENCES 142 (2015): 60-65. https://doi.org/10.1016/j.lfs.2015.10.015. Published • 10.1016/j.lfs.2015.10.015 Soares J; Raimundo L; Pereira NA; Dos Santos DJ; Pérez M; Queiroz G; Leão M; Santos MM; Saraiva L. "A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins.". PHARMACOLOGICAL RESEARCH 95-96 (2015): 42-52. https://doi.org/10.1016/j.phrs.2015.03.006. Published • 10.1016/j.phrs.2015.03.006 Soares, J.; Pereira, N.A.L.; Monteiro, Â.; Leão, M.; Bessa, C.; Dos Santos, D.J.V.A.; Raimundo, L.; et al. "Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction". European Journal of Pharmaceutical Sciences 66 (2015): 138-147. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908509142&partnerID=MN8TOARS. 10.1016/j.ejps.2014.10.006 Santos, J.M.; Benite-Ribeiro, S.A.; Queiroz, G.; Duarte, J.A.. "The interrelation between aPKC and glucose uptake in the skeletal muscle during contraction and insulin stimulation". Cell Biochemistry and Function 32 8 (2014): 621-624. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919684739&partnerID=MN8TOARS. 10.1002/cbf.3081 Quintas C; Pinho D; Pereira C; Saraiva L; Gonçalves J; Queiroz G. "Microglia P2Y6 receptors mediate nitric oxide release and astrocyte apoptosis.". JOURNAL OF NEUROINFLAMMATION 11 141 (2014): 1-12. http://www.jneuroinflammation.com/content/11/1/141. Open access • Published • 10.1186/s12974-014-0141-3 Pinho, D.; Quintas, C.; Sardo, F.; Cardoso, T.M.; Queiroz, G.. "Purinergic modulation of norepinephrine release and uptake in rat brain cortex: Contribution of glial cells". Journal of Neurophysiology 110 11 (2013): 2580-2591. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888616553&partnerID=MN8TOARS. 10.1152/jn.00708.2012 dos Santos, J.M.; Benite-Ribeiro, S.A.; Queiroz, G.; Duarte, J.A.; Santos, J. M.; Benite-Ribeiro, S. A.; Duarte, J. A.. "The effect of age on glucose uptake and GLUT1 and GLUT4 expression in rat skeletal muscle". Cell Biochemistry and Function 30 3 (2012): 191-197. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859442434&partnerID=MN8TOARS. Published • 10.1002/cbf.1834 Quintas, C.; Fraga, S.; Gonçalves, J.; Queiroz, G.. "Opposite modulation of astroglial proliferation by adenosine 5'-O-(2-thio)-diphosphate and 2-methylthioadenosine-5'-diphosphate: Mechanisms involved". Neuroscience 182 (2011): 32-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955484486&partnerID=MN8TOARS. 10.1016/j.neuroscience.2011.03.009 Talaia, C.; Morato, M.; Quintas, C.; Gonçalves, J.; Queiroz, G.. "Functional crosstalk of prejunctional receptors on the modulation of noradrenaline release in mesenteric vessels: A differential study of artery and vein". European Journal of Pharmacology 652 1-3 (2011): 33-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650912807&partnerID=MN8TOARS. 10.1016/j.ejphar.2010.10.075 Quintas, C.; Fraga, S.; Gonçalves, J.; Queiroz, G.. "P2Y receptors on astrocytes and microglia mediate opposite effects in astroglial proliferation". Purinergic Signalling 7 2 (2011): 251-263. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960978463&partnerID=MN8TOARS. 10.1007/s11302-011-9235-x Santos JM; Ribeiro SB; Glória Queiróz; Apell HJ; Duarte JA. "In vitro glucose uptake induced by electrical stimulation in soleus muscle. Does the stimulation frequency matter?". (2010): http://ciafel.fade.up.pt/ojs/index.php/AEHD/index. Published Neves, José Manuel; Matos, Carla; Moutinho, Carla; Queiroz, Glória; Gomes, Lígia Rebelo. "Ethnopharmacological notes about ancient uses of medicinal plants in Trás-os-Montes (northern of Portugal)". Journal of Ethnopharmacology 124 2 (2009): 270-283. http://dx.doi.org/10.1016/j.jep.2009.04.041. 10.1016/j.jep.2009.04.041 Quintas, C.; Fraga, S.; Gonçalves, J.; Queiroz, G.. "The P2Y1 and P2Y12 receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues". Neurochemistry International 55 7 (2009): 505-513. http://www.scopus.com/inward/record.url?eid=2-s2.0-69349096676&partnerID=MN8TOARS. 10.1016/j.neuint.2009.05.002 Carlos Talaia; Gloria Queiroz; Helder Pinheiro; Daniel Moura; Jorge Goncalves; Talaia, C.; Queiroz, G.; et al. "Involvement of G-protein beta gamma subunits on the influence of inhibitory alpha(2)-autoreceptors on the angiotensin AT(1)-receptor modulation of noradrenaline release in the rat vas deferens". Neurochemistry International 49 7 (2006): 698-707. https://repositorio-aberto.up.pt/handle/10216/96534. 10.1016/j.neuint.2006.07.002 Talaia, C.; Queiroz, G.; Quintas, C.; Gonçalves, J.. "Interaction between adenosine A2B-receptors and alfa2-adrenoceptors on the modulation of noradrenaline release in the rat vas deferens: Possible involvement of a group 2 adenylyl cyclase isoform". Neurochemistry International 47 6 (2005): 418-429. http://www.scopus.com/inward/record.url?eid=2-s2.0-24144469367&partnerID=MN8TOARS. 10.1016/j.neuint.2005.05.013 Queiroz, G.; Quintas, C.; Talaia, C.; Gonçalves, J.. "Coupling to protein kinases A and C of adenosine A2B receptors involved in the facilitation of noradrenaline release in the prostatic portion of rat vas deferens". Neuropharmacology 47 2 (2004): 216-224. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042660300&partnerID=MN8TOARS. 10.1016/j.neuropharm.2004.03.015 Queiroz, G.; Talaia, C.; Gonçalves, J.. "ATP Modulates Noradrenaline Release by Activation of Inhibitory P2Y Receptors and Facilitatory P2X Receptors in the Rat Vas Deferens". Journal of Pharmacology and Experimental Therapeutics 307 2 (2003): 809-815. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142179138&partnerID=MN8TOARS. 10.1124/jpet.103.054809 Queiroz, G.; Talaia, C.; Gonçalves, J.. "Adenosine A2A receptor-mediated facilitation of noradrenaline release involves protein kinase C activation and attenuation of presynaptic inhibitory receptor-mediated effects in the rat vas deferens". Journal of Neurochemistry 85 3 (2003): 740-748. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038335005&partnerID=MN8TOARS. 10.1046/j.1471-4159.2003.01715.x Fresco P; Diniz C; Queiroz G; Gonçalves J. "Release inhibitory receptors activation favours the A2A-adenosine receptor-mediated facilitation of noradrenaline release in isolated rat tail artery.". (2002): http://europepmc.org/abstract/med/12010771. 10.1038/sj.bjp.0704686 Queiroz, G.; Diniz, C.; Gonçalves, J.. "Facilitation of noradrenaline release by adenosine A2A receptors in the epididymal portion and adenosine A2B receptors in the prostatic portion of the rat vas deferens". European Journal of Pharmacology 448 1 (2002): 45-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037067360&partnerID=MN8TOARS. 10.1016/S0014-2999(02)01906-4 Queiroz, G.; Meyer, D.K.; Meyer, A.; Starke, K.; Von Kügelgen, I.. "A study of the mechanism of the release of ATP from rat cortical astroglial cells evoked by activation of glutamate receptors". Neuroscience 91 3 (1999): 1171-1181. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032962110&partnerID=MN8TOARS. 10.1016/S0306-4522(98)00644-7 Carvalho, F.; Remião, F.; Soares, M.E.; Catarino, R.; Queiroz, G.; Bastos, M.L.. "d-Amphetamine-induced hepatotoxicity: Possibie contribution of catecholamines and hyperthermia to the effect studied in isolated rat hepatocytes". Archives of Toxicology 71 7 (1997): 429-436. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030927810&partnerID=MN8TOARS. 10.1007/s002040050407 Queiroz, G.; Gebicke-Haerter, P.J.; Schobert, A.; Starke, K.; Von Kügelgen, I.. "Release of ATP from cultured rat astrocytes elicited by glutamate receptor activation". Neuroscience 78 4 (1997): 1203-1208. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030950658&partnerID=MN8TOARS. 10.1016/s0306-4522(96)00637-9 Gonçalves, J.; Queiroz, G.. "Purinoceptor modulation of noradrenaline release in rat tail artery: Tonic modulation mediated by inhibitory P2Y- And facilitatory A2A-purinoceptors". British Journal of Pharmacology 117 1 (1996): 156-160. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030046027&partnerID=MN8TOARS. 10.1111/J.1476-5381.1996.TB15168.X Queiroz, G.; Gonçalves, J.; Carvalho, M.; Vale, P.. "Electrically-evoked release of taurine in the rat vas deferens: evidence for a purinoceptor-mediated effect". Naunyn-Schmiedeberg's Archives of Pharmacology 351 1 (1995): 60-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028872991&partnerID=MN8TOARS. 10.1007/bf00169065 Jorge Gonçalves; Glória Queiroz; Gonçalves J; Queiroz G; Gon¿alves, J; Queiroz, G. "Facilitatory and inhibitory modulation by endogenous adenosine of noradrenaline release in the epididymal portion of rat vas deferens". Naunyn-Schmiedeberg's Archives of Pharmacology - Naunyn-Schmiedeberg's Arch Pharmacol (1993): https://repositorio-aberto.up.pt/handle/10216/92074. 10.1007/bf00171335
Thesis / Dissertation	Queiroz, Maria da Glória Correia da Silva. "Glutamate-evoked release of ATP from cortical astroglial cells". PhD, Universidade do Porto Faculdade de Farmácia, 1999. http://hdl.handle.net/10216/9919.

Award

1998	Farmacologia by UCB Pharma (Produtos Farmacêuticos) Lda UCB Pharma (Produtos Farmacêuticos) Lda, Portugal