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I completed a PhD in Health Sciences - Biomedical and Biological sciences in 2007 (School of Medicine, University of Minho) on the mechanisms of protection and pathogenesis of Mycobacterium ulcerans infection. After my PhD, I moved to the Trudeau Institute (Saranac Lake, NY, USA) as a Postdoc in the Lab of Andrea M. Cooper to study the immunological mechanisms that regulate the expression and maintenance of CD4 T cells to Mycobacterium tuberculosis infection. I am currently Auxiliary Researcher in the Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. My research program at the ICVS aims to deepen our understanding on the mechanisms that regulate immune responses in the lung. Our overarching goal is to learn novel ways to instruct immunity to improve vaccination and develop novel immunotherapies. Throughout my scientific career, I published over 50 articles in International peer reviewed journals (h-index= 28; >2600 citations), 4 books chapters and has edited 1 book. I have also organized 4 events and supervised 3 PhD and 11 MSc dissertations. Currently I am a Principal investigator in 2 projects and a Researcher in 1 project. Given my expertise in immunology and vaccination, I have been serving as member in the National Immunization Technical Advisory Group since 2023.
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Identification

Personal identification

Full name
Egídio Torrado

Citation names

  • Torrado, Egídio

Author identifiers

Ciência ID
C918-5186-E297
ORCID iD
0000-0002-7462-8234
Researcher Id
T-5156-2018
Scopus Author Id
57198982131

Email addresses

  • egidiotorrado@med.uminho.pt (Professional)

Telephones

Telephone
  • 253604907 (Professional)

Addresses

  • Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057, Braga, Braga, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2)
Education
Degree Classification
2007/10/15
Concluded
 Health Sciences - Biomedical and Biological sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
"Cellular immune response to experimental infections with mycobacteria with different degrees of virulence : development of new preventive strategies" (THESIS/DISSERTATION)
2003/10/07
Concluded
 Biotechnology - Bioprocess Engineering (Mestrado)
Universidade do Minho Departamento de Engenharia Biológica, Portugal
"Study of the role of Candida albicans and Mycobacterium avium secreted proteins on experimental infections and their potential as target antigens in immunoprotection studies" (THESIS/DISSERTATION)
 Muito Bom
2000/09/07
Concluded
 Biology (Licenciatura)
Universidade de Aveiro, Portugal
 14
Affiliation

Science

Category
Host institution 		Employer
2015/07/01 - Current Auxiliary Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013/11/01 - 2015/06/30 Invited Auxiliary Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013/04/15 - 2013/08/31 Researcher (Research) Trudeau Institute Inc, United States
Trudeau Institute Inc, United States
2008/04/15 - 2013/04/15 Postdoc (Research) Trudeau Institute Inc, United States
Trudeau Institute Inc, United States
2001/04/01 - 2003/03/31 Research Trainee (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2014/09/01 - Current Invited Assistant Professor (University Teacher) Universidade do Minho, Portugal
Universidade do Minho Escola de Medicina, Portugal

Others

Category
Host institution 		Employer
2003/04/01 - 2007/10/15 PhD student Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Escola de Medicina, Portugal
Projects

Grant

Designation Funders
2024 - 2025 Unveiling tuberculosis susceptibility: the key role of alveolar macrophages
ESCMID research grants 2024
Principal investigator
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Ongoing
2023/01/01 - 2024/12/31 Sporob_SiA: Elucidation of the role of sialidase 1 in the severity of feline sporotrichosis caused by Sporothrix brasiliensis
2022.03348.PTDC
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020/10/01 - 2023/09/30 HEALTH-UNORTE: Setting-up biobanks and regenerative medicine strategies to boost research in cardiovascular, musculoskeletal, neurological, oncological, immunological and infectious diseases
NORTE-01-0145-FEDER-000039
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Concluded
2019/04/10 - 2023/04/09 Sourdough biotechnology network towards novel, healthier and sustainable food and bioprocesses
CA18101
Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
European Cooperation in Science and Technology
Ongoing
2021 - 2023 Janus Approach to Cancer Theranostics (JUSThera)
NORTE-01-0145-FEDER-000055
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Ongoing
2018/07/15 - 2022/06/14 Immunological basis of failure in controlling Mycobacterium tuberculosis infection
PTDC/SAU-INF/28463/2017
Principal investigator
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2021/12/31 Microbiota in cancer immunesurveillance: new avenues for immunotherapy
PTDC/MED-ONC/28658/2017
Principal investigator
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2015/07/01 - 2020/06/30 Impact of the inflammatory environment on the CD4 T cell response to Mycobacterium tuberculosis: identification of correlates of protection
IF/01390/2014
Principal investigator
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/04/01 - 2020/03/31 New avenues for the development of personalized medical interventions for neurological, oncologic and surgical disorders - "PersonalizedNOS".
NORTE-01-0145-FEDER-000013
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Ongoing

Contract

Designation Funders
2021/07/01 - 2027/06/30 Targeting innate and acquired immunity as a new paradigm for tuberculosis vaccination
2020.03070.CEEIND
Principal investigator
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Ongoing
Outputs

Publications

Book
  1. Torrado, E.; Silvestre, R.. Metabolic Interaction in Infection. Springer International Publishing. 2018.
    10.1007/978-3-319-74932-7
Book chapter
  1. Torrado, E.; Van Crevel, R.; Afonso, A.R.; Amorim, D.; Duarte, R.. "Protecting the most vulnerable: Tuberculosis in immunocompromised individuals". In ERS Monograph, 235-250. 2023.
    10.1183/2312508X.10025422
  2. Ferreira, C.M.; Barbosa, A.M.; Pereira, I.M.; Torrado, E.. "Metabolic host response to intracellular infections". In Metabolic Interaction in Infection, edited by Torrado, E.; Silvestre, R., 319-350. Springer International Publishing, 2018.
    Published • 10.1007/978-3-319-74932-7_8
  3. Mesquita, I.; Torrado, E.; Silvestre, R.. "O sistema imunológico como alvo da toxicidade dos xenobióticos". In Toxicologia fundamental, edited by Dinis-Oliveira, R.J.; Carvalho, F.D.; Bastos, M.L., 201-217. Portugal: LIDL, 2018.
  4. Barreira-Silva, P.; Torrado, E.; Nebenzahl-Guimaraes, H.; Kallenius, G.; Correia-Neves, M.. "Aetiopathogenesis, immunology and microbiology". In ERS Monograph, 62-82. 2018.
    10.1183/2312508X.10020917
  5. Torrado, E.; Cooper, A.M.. "Cytokines in the balance of protection and pathology during mycobacterial infections". In The New Paradigm of Immunity to Tuberculosis, edited by Divangahi, M., 121-140. Springer New York, 2013.
    10.1007/978-1-4614-6111-1_7
Journal article
  1. Steenwyk, Jacob L.; Knowles, Sonja; Bastos, Rafael W.; Balamurugan, Charu; Rinker, David; Mead, Matthew E.; Roberts, Christopher D.; et al. "Evolutionary origin and population diversity of a cryptic hybrid pathogen". Nature Communications 15 1 (2024): http://doi.org/10.1038/s41467-024-52639-1.
    10.1038/s41467-024-52639-1
  2. Costa-Barbosa, A.; Ferreira, D.; Pacheco, M.I.; Casal, M.; Duarte, H.O.; Gomes, C.; Barbosa, A.M.; et al. "Candida albicans chitinase 3 with potential as a vaccine antigen: production, purification, and characterisation". Biotechnology Journal 19 1 (2024): https://doi.org/10.1002/biot.202300219.
    10.1002/biot.202300219
  3. Paula Roberta Aguiar Pastrez; Ana Margarida Barbosa; Vânia Sammartino Mariano; Rhafaela Lima Causin; Antonio Gil Castro; Egídio Torrado; Adhemar Longatto-Filho. "Interleukin-8 and Interleukin-6 Are Biomarkers of Poor Prognosis in Esophageal Squamous Cell Carcinoma". Cancers (2023): https://doi.org/10.3390/cancers15071997.
    10.3390/cancers15071997
  4. Tavares, M.; Sousa-Filho, J.C.; Machado, I.A.; Gonçales, R.A.; Antunes, D.; Mendes-Frias, A.; Silvestre, R.; et al. "Development of a Versatile Toolbox for Genetic Manipulation of Sporothrix brasiliensis". Microbiology Spectrum 11 2 (2023): https://doi.org/10.1128/spectrum.04564-22.
    10.1128/spectrum.04564-22
  5. Antunes, D.; Gonçalves, S.M.; Matzaraki, V.; Rodrigues, C.S.; Gonçales, R.A.; Rocha, J.; Sáiz, J.; et al. "Glutamine Metabolism Supports the Functional Activity of Immune Cells against Aspergillus fumigatus". Microbiology Spectrum 11 1 (2023): https://doi.org/10.1128/spectrum.02256-22.
    10.1128/spectrum.02256-22
  6. A.L. Alves; J. Costa-Gouveia; J. Vieira de Castro; C.G. Sotelo; J.A. Vázquez; R.I. Pérez-Martín; E. Torrado; et al. "Study of the immunologic response of marine-derived collagen and gelatin extracts for tissue engineering applications". Acta Biomaterialia (2022): https://doi.org/10.1016/j.actbio.2022.01.009.
    10.1016/j.actbio.2022.01.009
  7. Ferreira, C.M.; Micheli, C.; Barreira-Silva, P.; Barbosa, A.M.; Resende, M.; Vilanova, M.; Silvestre, R.; et al. "IL-10 Overexpression After BCG Vaccination Does Not Impair Control of Mycobacterium tuberculosis Infection". Frontiers in Immunology 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85135460833&partnerID=MN8TOARS.
    10.3389/fimmu.2022.946181
  8. da Silva-Ferreira, S.; Duarte-Oliveira, C.; Antunes, D.; Barbosa-Matos, C.; Mendes-Frias, A.; Torrado, E.; Costa, S.; et al. "Hypoxia inducible-factor 1 alpha regulates neutrophil recruitment during fungal-elicited granulomatous inflammation". Frontiers in Cellular and Infection Microbiology 12 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85140258109&partnerID=MN8TOARS.
    10.3389/fcimb.2022.1005839
  9. Gonçales, R.A.; Bastos, H.N.; Duarte-Oliveira, C.; Antunes, D.; Sokhatska, O.; Jacob, M.; Rolo, R.; et al. "Pentraxin 3 Inhibits Complement-driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis". American Journal of Respiratory and Critical Care Medicine 206 9 (2022): 1140-1152. http://www.scopus.com/inward/record.url?eid=2-s2.0-85139726848&partnerID=MN8TOARS.
    10.1164/rccm.202112-2771OC
  10. Catarina M. Ferreira; Ana Margarida Barbosa; Palmira Barreira-Silva; Ricardo Silvestre; Cristina Cunha; Agostinho Carvalho; Fernando Rodrigues; et al. "Early IL-10 promotes vasculature-associated CD4+ T cells unable to control Mycobacterium tuberculosis infection". JCI Insight (2021): https://doi.org/10.1172/jci.insight.150060.
    10.1172/jci.insight.150060
  11. Martínez-Pérez, A.; Igea, A.; Estévez, O.; Ferreira, C.M.; Torrado, E.; Castro, A.G.; Fernández, C.; et al. "Changes in the immune phenotype and gene expression profile driven by a novel tuberculosis nanovaccine: short and long-term post-immunization". Frontiers in Immunology 11 (2021): https://doi.org/10.3389/fimmu.2020.589863.
    10.3389/fimmu.2020.589863
  12. Barbosa, A.M.; Gomes-Gonçalves, A.; Castro, A.G.; Torrado, E.. "Immune System Efficiency in Cancer and the Microbiota Influence". Pathobiology (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85100882639&partnerID=MN8TOARS.
    10.1159/000512326
  13. Barbosa, A.M.; Martinho, O.; Nogueira, R.; Campos, J.; Lobo, L.; Pinto, H.; Longatto-Filho, A.; et al. "Increased CD3+, CD8+, or FoxP3+ T lymphocyte infiltrations are associated with the pathogenesis of colorectal cancer but not with the overall survival of patients". Biology 10 8 (2021): https://doi.org/10.3390/biology10080808.
    10.3390/biology10080808
  14. Resende, M.; Ferreira, C.M.; Barbosa, A.M.; Cardoso, M.S.; Sousa, J.; Saraiva, M.; Castro, A.G.; Appelberg, R.; Torrado, E.. "Myeloid HIF-1a regulates pulmonary inflammation during experimental Mycobacterium tuberculosis infection". Immunology 159 1 (2020): 121-129. https://doi.org/10.1111/imm.13131.
    10.1111/imm.13131
  15. Mesquita, I.; Ferreira, C.; Moreira, D.; Kluck, G.E.G.; Barbosa, A.M.; Torrado, E.; Dinis-Oliveira, R.J.; et al. "The Absence of HIF-1a Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis". Cell Reports 30 12 (2020): 4052-4064.e7. http://www.scopus.com/inward/record.url?eid=2-s2.0-85082017989&partnerID=MN8TOARS.
    10.1016/j.celrep.2020.02.098
  16. Ferreira, C.; Mesquita, I.; Barbosa, A.M.; Osório, N.S.; Torrado, E.; Beauparlant, C.-J.; Droit, A.; et al. "Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis". PLoS neglected tropical diseases 14 3 (2020): e0008125-e0008125. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083003111&partnerID=MN8TOARS.
    10.1371/journal.pntd.0008125
  17. Gonçalves, S.M.; Duarte-Oliveira, C.; Campos, C.F.; Aimanianda, V.; ter Horst, R.; Leite, L.; Mercier, T.; et al. "Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity". Nature Communications 11 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85084721395&partnerID=MN8TOARS.
    10.1038/s41467-020-16120-z
  18. Vale, A.C.; Pereira, P.R.; Barbosa, A.M.; Torrado, E.; Alves, N.M.. "Optimization of silver-containing bioglass nanoparticles envisaging biomedical applications". Materials Science and Engineering C 94 (2019): 161-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053202927&partnerID=MN8TOARS.
    10.1016/j.msec.2018.09.027
  19. Ferreira, B.H.; Ramírez-Prado, J.H.; Neves, G.W.P.; Torrado, E.; Sampaio, P.; Felipe, M.S.S.; Vasconcelos, A.T.; et al. "Ploidy determination in the pathogenic fungus Sporothrix spp". Frontiers in Microbiology 10 FEB (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85065901091&partnerID=MN8TOARS.
    10.3389/fmicb.2019.00284
  20. Vale, A.C.; Pereira, P.; Barbosa, A.M.; Torrado, E.; Mano, J.F.; Alves, N.M.. "Antibacterial free-standing polysaccharide composite films inspired by the sea". International Journal of Biological Macromolecules 133 (2019): 933-944. http://www.scopus.com/inward/record.url?eid=2-s2.0-85064860564&partnerID=MN8TOARS.
    10.1016/j.ijbiomac.2019.04.102
  21. Campos, C.F.; Leite, L.; Pereira, P.; Vaz, C.P.; Branca, R.; Campilho, F.; Freitas, F.; et al. "PTX3 polymorphisms influence cytomegalovirus reactivation after stem-cell transplantation". Frontiers in Immunology 10 JAN (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85061583920&partnerID=MN8TOARS.
    10.3389/fimmu.2019.00088
  22. Vale, A.C.; Carvalho, A.L.; Barbosa, A.M.; Torrado, E.; Mano, J.F.; Alves, N. M.. "Novel antibacterial and bioactive silicate glass nanoparticles for biomedical applications". (2018): http://hdl.handle.net/1822/50827.
    Open access • 10.1002/adem.201700855
  23. Gaifem, J.; Gonçalves, L.G.; Dinis-Oliveira, R.J.; Cunha, C.; Carvalho, A.; Torrado, E.; Rodrigues, F.; et al. "L-threonine supplementation during colitis onset delays disease recovery". Frontiers in Physiology 9 SEP (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85053078274&partnerID=MN8TOARS.
    10.3389/fphys.2018.01247
  24. Mesquita, I.; Ferreira, C.; Barbosa, A.M.; Ferreira, C.M.; Moreira, D.; Carvalho, A.; Cunha, C.; et al. "The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis". Cytokine (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85049860664&partnerID=MN8TOARS.
    10.1016/j.cyto.2018.07.001
  25. Fraga, A.G.; Barbosa, A.M.; Ferreira, C.M.; Fevereiro, J.; Pedrosa, J.; Torrado, E.. "Immune-evasion Strategies of Mycobacteria and Their Implications for the Protective Immune Response". Current issues in molecular biology 25 (2018): 169-198. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051180908&partnerID=MN8TOARS.
    10.21775/cimb.025.169
  26. Miranda, M.S.; Rodrigues, M.T.; Domingues, R.M.A.; Costa, R.R.; Paz, E.; Rodríguez-Abreu, C.; Freitas, P.; et al. "Development of Inhalable Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in Microparticulate System for Antituberculosis Drug Delivery". Advanced Healthcare Materials 7 15 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85047565774&partnerID=MN8TOARS.
    10.1002/adhm.201800124
  27. Bhatt, K.; Machado, H.; Osório, N.S.; Sousa, J.; Cardoso, F.; Magalhães, C.; Chen, B.; et al. "A nonribosomal peptide synthase gene driving virulence in Mycobacterium tuberculosis". mSphere 3 5 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85055835714&partnerID=MN8TOARS.
    10.1128/mSphere.00352-18
  28. Miranda, M.S.; Rodrigues, M.T.; Domingues, R.M.A.; Torrado, E.; Reis, R.L.; Pedrosa, J.; Gomes, M.E.. "Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery". Materials Science and Engineering C 93 (2018): 1090-1103. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053031449&partnerID=MN8TOARS.
    10.1016/j.msec.2018.09.004
  29. Cunha, C.; Gonçalves, S.M.; Duarte-Oliveira, C.; Leite, L.; Lagrou, K.; Marques, A.; Lupiañez, C.B.; et al. "IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity". Journal of Allergy and Clinical Immunology (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85019152778&partnerID=MN8TOARS.
    10.1016/j.jaci.2017.02.034
  30. Moreira-Teixeira, L.; Sousa, J.; McNab, F.W.; Torrado, E.; Cardoso, F.; Machado, H.; Castro, F.; et al. "Type i IFN inhibits alternative macrophage activation during mycobacterium tuberculosis infection and leads to enhanced protection in the absence of IFN-¿ signaling". Journal of Immunology 197 12 (2016): 4714-4726. http://www.scopus.com/inward/record.url?eid=2-s2.0-85002328285&partnerID=MN8TOARS.
    10.4049/jimmunol.1600584
  31. Carvalho, A.L.; Vale, A.C.; Sousa, M.P.; Barbosa, A.M.; Torrado, E.; Mano, J.F.; Alves, N.M.; et al. "Antibacterial bioadhesive layer-by-layer coatings for orthopedic applications". Journal of Materials Chemistry B 4 32 (2016): 5385-5393. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982170331&partnerID=MN8TOARS.
    10.1039/c6tb00841k
  32. Cruz, A.; Torrado, E.; Carmona, J.; Fraga, A.G.; Costa, P.; Rodrigues, F.; Appelberg, R.; et al. "BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4+IL-17+TNF+IL-2+ T cells". Vaccine 33 1 (2015): 85-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919360521&partnerID=MN8TOARS.
    10.1016/j.vaccine.2014.11.013
  33. Macho-Fernandez, E.; Koroleva, E.P.; Spencer, C.M.; Tighe, M.; Torrado, E.; Cooper, A.M.; Fu, Y.-X.; Tumanov, A.V.. "Lymphotoxin beta receptor signaling limits mucosal damage through driving IL-23 production by epithelial cells". Mucosal Immunology 8 2 (2015): 403-413. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922704823&partnerID=MN8TOARS.
    10.1038/mi.2014.78
  34. Torrado, E.; Fountain, J.J.; Liao, M.; Tighe, M.; Reiley, W.W.; Lai, R.P.; Meintjes, G.; et al. "Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection". Journal of Experimental Medicine 212 9 (2015): 1449-1463. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957442285&partnerID=MN8TOARS.
    10.1084/jem.20141520
  35. Cruz, A.; Ludovico, P.; Torrado, E.; Gama, J.B.; Sousa, J.; Gaifem, J.; Appelberg, R.; et al. "IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis of infected macrophages". Frontiers in Immunology 6 SEP (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84946550863&partnerID=MN8TOARS.
    10.3389/fimmu.2015.00498
  36. Okada, S.; Markle, J.G.; Deenick, E.K.; Mele, F.; Averbuch, D.; Lagos, M.; Alzahrani, M.; et al. "Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations". Science 349 6248 (2015): 606-613. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939154723&partnerID=MN8TOARS.
    10.1126/science.aaa4282
  37. Cardoso, F.; Castro, F.; Moreira-Teixeira, L.; Sousa, J.; Torrado, E.; Silvestre, R.; Castro, A.G.; Saraiva, M.; Pais, T.F.. "Myeloid sirtuin 2 expression does not impact long-term Mycobacterium tuberculosis control". PLoS ONE 10 7 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84940426429&partnerID=MN8TOARS.
    10.1371/journal.pone.0131904
  38. Torrado, E.; Fountain, J.J.; Robinson, R.T.; Martino, C.A.; Pearl, J.E.; Rangel-Moreno, J.; Tighe, M.; Dunn, R.; Cooper, A.M.. "Differential and Site Specific Impact of B Cells in the Protective Immune Response to Mycobacterium tuberculosis in the Mouse". PLoS ONE 8 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84876194618&partnerID=MN8TOARS.
    10.1371/journal.pone.0061681
  39. Fraga, A.G.; Martins, T.G.; Torrado, E.; Huygen, K.; Portaels, F.; Silva, M.T.; Castro, A.G.; Pedrosa, J.. "Cellular immunity confers transient protection in experimental buruli ulcer following BCG or mycolactone-negative mycobacterium ulcerans vaccination". PLoS ONE 7 3 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84857837898&partnerID=MN8TOARS.
    10.1371/journal.pone.0033406
  40. Cooper, A.M.; Torrado, E.. "Protection versus pathology in tuberculosis: Recent insights". Current Opinion in Immunology 24 4 (2012): 431-437. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865301803&partnerID=MN8TOARS.
    10.1016/j.coi.2012.04.008
  41. Pearl, J.E.; Torrado, E.; Tighe, M.; Fountain, J.J.; Solache, A.; Strutt, T.; Swain, S.; Appelberg, R.; Cooper, A.M.. "Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection". European Journal of Immunology 42 12 (2012): 3267-3279. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871273202&partnerID=MN8TOARS.
    10.1002/eji.201142158
  42. Carvalho, A.; Cunha, C.; Almeida, A.J.; Osório, N.S.; Saraiva, M.; Teixeira-Coelho, M.; Pedreiro, S.; et al. "The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma". Genes and Immunity 13 2 (2012): 197-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857787435&partnerID=MN8TOARS.
    10.1038/gene.2011.59
  43. Fraga, A.G.; Cruz, A.; Martins, T.G.; Torrado, E.; Saraiva, M.; Pereira, D.R.; Meyers, W.M.; et al. "Mycobacterium ulcerans triggers T-cell immunity followed by local and regional but not systemic immunosuppression". Infection and Immunity 79 1 (2011): 421-430. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650893587&partnerID=MN8TOARS.
    10.1128/IAI.00820-10
  44. Torrado, E.; Cooper, A.M.. "What do we really know about how cd4 t cells control mycobacterium tuberculosis?". PLoS Pathogens 7 7 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79960964461&partnerID=MN8TOARS.
    10.1371/journal.ppat.1002196
  45. Torrado, E.; Robinson, R.T.; Cooper, A.M.. "Cellular response to mycobacteria: Balancing protection and pathology". Trends in Immunology 32 2 (2011): 66-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-79751529842&partnerID=MN8TOARS.
    10.1016/j.it.2010.12.001
  46. Torrado, E.; Cooper, A.M.. "IL-17 and Th17 cells in tuberculosis". Cytokine and Growth Factor Reviews 21 6 (2010): 455-462. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649687687&partnerID=MN8TOARS.
    10.1016/j.cytogfr.2010.10.004
  47. Cruz, A.; Fraga, A.G.; Fountain, J.J.; Rangel-Moreno, J.; Torrado, E.; Saraiva, M.; Pereira, D.R.; et al. "Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis". Journal of Experimental Medicine 207 8 (2010): 1609-1616. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955390095&partnerID=MN8TOARS.
    10.1084/jem.20100265
  48. Torrado, E.; Fraga, A.G.; Logarinho, E.; Martins, T.G.; Carmona, J.A.; Gama, J.B.; Carvalho, M.A.; et al. "IFN-¿-dependent activation of macrophages during experimental infections by Mycobacterium ulcerans is impaired by the toxin mycolactone". Journal of Immunology 184 2 (2010): 947-955. http://www.scopus.com/inward/record.url?eid=2-s2.0-76249087225&partnerID=MN8TOARS.
    10.4049/jimmunol.0902717
  49. Gonçalves, C.; Torrado, E.; Martins, T.; Pereira, P.; Pedrosa, J.; Gama, M.. "Dextrin nanoparticles: Studies on the interaction with murine macrophages and blood clearance". Colloids and Surfaces B: Biointerfaces 75 2 (2010): 483-489. http://www.scopus.com/inward/record.url?eid=2-s2.0-70549098806&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2009.09.024
  50. Portaels, F.; Meyers, W.M.; Ablordey, A.; Castro, A.G.; Chemlal, K.; de Rijk, P.; Elsen, P.; et al. "First cultivation and characterization of Mycobacterium ulcerans from the environment". PLoS Neglected Tropical Diseases 2 3 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-48949118021&partnerID=MN8TOARS.
    10.1371/journal.pntd.0000178
  51. Torrado, E.; Adusumilli, S.; Fraga, A.G.; Small, P.L.C.; Castro, A.G.; Pedrosa, J.. "Mycolactone-mediated inhibition of tumor necrosis factor production by macrophages infected with Mycobacterium ulcerans has implications for the control of infection". Infection and Immunity 75 8 (2007): 3979-3988. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547624336&partnerID=MN8TOARS.
    10.1128/IAI.00290-07
  52. Torrado, E.; Fraga, A.G.; Castro, A.G.; Stragier, P.; Meyers, W.M.; Portaels, F.; Silva, M.T.; Pedrosa, J.. "Evidence for an intramacrophage growth phase of Mycobacterium ulcerans". Infection and Immunity 75 2 (2007): 977-987. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846781153&partnerID=MN8TOARS.
    10.1128/IAI.00889-06
  53. Cruz, A.; Khader, S.A.; Torrado, E.; Fraga, A.; Pearl, J.E.; Pedrosa, J.; Cooper, A.M.; Castro, A.G.. "Cutting edge: IFN-¿ regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection". Journal of Immunology 177 3 (2006): 1416-1420. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746215298&partnerID=MN8TOARS.
  54. Oliveira, M.S.; Fraga, A.G.; Torrado, E.; Castro, A.G.; Pereira, J.P.; Longatto Filho, A.; Milanezi, F.; et al. "Infection with Mycobacterium ulcerans induces persistent inflammatory responses in mice". Infection and Immunity 73 10 (2005): 6299-6310. http://www.scopus.com/inward/record.url?eid=2-s2.0-25444518934&partnerID=MN8TOARS.
    10.1128/IAI.73.10.6299-6310.2005
  55. Vilanova, M.; Teixeira, L.; Caramalho, Í.; Torrado, E.; Marques, A.; Madureira, P.; Ribeiro, A.; et al. "Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2". Immunology 111 3 (2004): 334-342. http://www.scopus.com/inward/record.url?eid=2-s2.0-12144286479&partnerID=MN8TOARS.
    10.1111/j.1365-2567.2004.01819.x
Online resource
  1. Cooper, A.M.; Torrado, E.. F1000Prime Recommendation. 2014. http://f1000.com/prime/718206675#eval793491896.
    10.3410/f.718206675.793491896
  2. Cooper, A.M.; Torrado, E.. F1000Prime Recommendation. 2013. http://f1000.com/prime/718022141#eval793488496.
    10.3410/f.718022141.793488496
  3. Cooper, A.M.; Torrado, E.. F1000Prime Recommendation. 2013. http://f1000.com/prime/718028160#eval793479998.
    10.3410/f.718028160.793479998
  4. Cooper, A.M.; Torrado, E.. F1000Prime Recommendation. 2013. http://f1000.com/prime/718028159#eval793479997.
    10.3410/f.718028159.793479997
Thesis / Dissertation
  1. Torrado, Egídio. "Cellular immune response to experimental infections with mycobacteria with different degrees of virulence : development of new preventive strategies". PhD, Universidade do Minho Escola de Medicina, 2007. http://hdl.handle.net/1822/7083.
  2. Torrado, Egídio. "Study of the role of Candida albicans and Mycobacterium avium secreted proteins on experimental infections and their potential as target antigens in immunoprotection studies". Master, Universidade do Minho Departamento de Engenharia Biológica, 2003.

Other

Other output
  1. Evolutionary origin, population diversity, and diagnostics for a cryptic hybrid pathogen. 2023. Steenwyk, J.L.; Knowles, S.; Bastos, R.W.; Balamurugan, C.; Rinker, D.; Mead, M.E.; Roberts, C.D.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85169549687&partnerID=MN8TOARS.
    10.1101/2023.07.03.547508
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11/10 Immune-mediated conditions that increase the risk for tuberculosis 9TH Union Europe Conference on Lung Health
Portuguese Society of Pneumology (Albufeira, Portugal)
2019/09/20 Impact of the inflammatory environment in the protective CD4 T cell response to Mycobacterium tuberculosis infection Mycoporto
(Porto, Portugal)
2018 HIF-1a induction supresses lipid accumulation in myeloid cells and protects against Leishmania donovani infection TwinnToInfect Spring School
(Portugal)
2018 Microbiota regulation of cancer immune surveillance XLIV meeting of the Portuguese Society of Immunology
Portuguese Society of Immunology (Portugal)
2017/07/13 TB, or not TB: does the lung environment hold the answer?
(Vigo, Spain)
2017 HIF-1a induction supresses lipid accumulation in myeloid cells and protects against Leishmania donovani infection XLIII Annual Meeting of the Portuguese Society of Immunology
Portuguese Society of Immunology (Portugal)
2017 Deciphering the microbiome and metabolome factors contributing to protection against ulcerative colitis XLIII Annual Meeting of the Portuguese Society of Immunology
Portuguese Society of Immunology (Portugal)
2017 A temporal role for IL-10 in regulating the lung inflammatory response to M. tuberculosis infection ICVS open day
(Portugal)
2015 IL-17 modulated macrophage metabolism: a role in cancer and inflammation XLI Annual Meeting of the Portuguese Society of Immunology
Portuguese Society of Immunology (Portugal)
2014/06/05 IL-27 in the protective CD4 T cell response to Mycobacterium tuberculosis
(Valencia, Spain)
2013 IL-27-sustained T-bet expression promotes the development of terminally differentiated CD4 T cells during tuberculosis XXXIX Annual Meeting of the Portuguese society for Immunology
Portuguese society for Immunology (Portugal)
2013 Impact of differential recognition of Mycobacterium tuberculosis strains by dendritic cells on the development of CD4+ T cell responses XXXIX Annual Meeting of the Portuguese Society for Immunology
Portuguese Society for Immunology (Portugal)
2013 IL-10 over-expression during T cell priming impacts the inflammatory response to Mycobacterium tuberculosis in the lung XXXIX Annual Meeting of the Portuguese society for Immunology
Portuguese society for Immunology (Portugal)
2012 IL-27 sustains T-bet expression and promotes the development of terminally differentiated CD4 T cells during tuberculosis Upstate New York Immunology Conference
(United States)
2012 IL-27 sustains T-bet expression and promotes the development of terminally differentiated CD4 T cells during tuberculosis Annual meeting of the American Association of Immunologists
American Association of Immunologists (United States)
2006 TNF plays a protective role in infections by low virulent strains of Mycobacterium ulcerans XXXII annual meeting of the Portuguese Society for Immunology
Portuguese Society for Immunology (Portugal)
2006 IL-17-producing CD4 T cells induced during mycobacterial infection are regulated by IFNg II national symposium of cytokines
(Portugal)
2003 Analysis of Mycobacterium ulcerans infection in bone-marrow derived macrophages XXIX annual meeting of the Portuguese Society for Immunology
Portuguese Society for Immunology (Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/01/01 - 2024/12/31 Immunometabolic pathways underlying resistance or susceptibility to Mycobacterium tuberculosis infection
Supervisor
Universidade do Minho Escola de Medicina, Portugal
2023/09/01 - 2024/06/30 Impact of early inflammatory events in vaccine-induced protection against Mycobacterium tuberculosis infection
Supervisor
Universidade do Minho Escola de Medicina, Portugal
2018/03/01 - 2022/07 Regulation of pulmonary CD4 T cell responses to Mycobacterium tuberculosis infection
Supervisor
 Health sciences (PhD)
Universidade do Minho Escola de Medicina, Portugal
2020/09/01 - 2022/01/31 The role of IL-23 in the immune response to Mycobacterium tuberculosis
Supervisor
Universidade do Minho Escola de Medicina, Portugal
2017/09/01 - 2022 Microbiota modulation of cancer immune surveillance
Supervisor
 Health sciences (PhD)
Universidade do Minho Escola de Medicina, Portugal
2020 - 2020 Avaliação da infiltração intratumoral de células T CD3+ e T CD8+ no Cancro Colorretal
Co-supervisor
 Medicina (Master)
Universidade do Minho Escola de Medicina, Portugal
2020 - 2020 Avaliação da expressão dos marcadores imunológicos T-bet e FoxP3 no Cancro Colorretal e a sua relação com o prognóstico
Co-supervisor
 Medicina (Master)
Universidade do Minho Escola de Medicina, Portugal
2018/06/01 - 2019/07/24 Expressão de marcadores imunológicos no Cancro Colorretal: papel no prognóstico
Supervisor
Universidade do Minho Escola de Medicina, Portugal
2017/09/01 - 2019/06/01 Is vaccine efficacy regulated by the gut microbiome?
Supervisor
 Molecular biology (Master)
Universidade do Minho Escola de Ciências, Portugal
2018/06/01 - 2019/01/04 O papel do zinco na modulação da microbiota intestinal e na resposta imunológica local e no tumor
Supervisor
Universidade do Minho Escola de Medicina, Portugal
2016/09/01 - 2017/06 Characterizing the initial cellular and molecular events of the protective immune response to Mycobacterium tuberculosis
Supervisor
 Health Sciences (Master)
Universidade do Minho Escola de Medicina, Portugal
2016 - 2016  The role of IL-10 in the immune response to cancer
Supervisor
 Health Sciences (Master)
Universidade do Minho Escola de Medicina, Portugal
2015/09/01 - 2016 The mechanisms underlying Mycobacterium Tuberculosis Virulence granted by the NRP gene
Supervisor
 Health Sciences (Master)
Universidade do Minho Escola de Medicina, Portugal
2015 - 2015 Evaluation of the imune-determinants associated with resistance/susceptibility to Paracoccidioides brasiliensis: a mouse model perspective
Supervisor
 Health Sciences (Master)
Universidade do Minho Escola de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2014/01/01 - Current Weekly scientific meetings of the Microbiology and Infection Research Domain (2014/01/01)
Meeting
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020/05/20 - 2020/05/22 XLVI annual meeting of the Portuguese society of immunology with the title "Current challenges and emerging topics in immunology" (2020/05/20 - 2020/05/22)
Congress (Member of the Organising Committee)
 Universidade do Minho Escola de Medicina, Portugal
2014/01/01 - 2017/12/31 ICVS international seminar series (2014/01/01)
Seminar
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015/10/26 - 2015/10/28 XLI annual meeting of the Portuguese society of immunology with the title "From basic Immunology to the latest clinical breakthroughs" (2015/10/26 - 2015/10/28)
Congress (Member of the Organising Committee)
 Universidade do Minho Escola de Medicina, Portugal
2011 - 2013 Journal club series (2011 - 2013)
Seminar (Member of the Organising Committee)
 Trudeau Institute Inc, United States

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/11/17 Dissecting the role of immunometabolism in granuloma formation in sarcoidosis
(Thesis) Arguer
 Ana Cláudia Pacheco Baptista (Master)
Universidade do Minho Escola de Medicina, Portugal
2023/09/22 Novel insights into the biology of IL-10
(Thesis) Main arguer
 Ana Catarina Martins (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/05/23 Host genetics of resistance to Mycobacterium ulcerans infection: bridging clinical and cellular/animal models
(Thesis) Arguer
 João Pedro Gouveia Fevereiro (PhD)
Universidade do Minho Escola de Medicina, Portugal
2023/04/19 The immune response to mycobacterial glycolipids in tuberculosis
(Thesis) Arguer
 Carolina Sousa Silva (PhD)
Universidade do Minho Escola de Medicina, Portugal
2022/11/25 An Innovative Therapeutic Approach For Infected Chronic Wounds
(Thesis) Arguer
 Ana Isabel da Silva Mendes (PhD)
Universidade do Minho Escola de Medicina, Portugal
2022/03/24 The role of SNAREs in chlamydial infection: Syntaxin 4 and SNAP-23 disrupt lipid droplets homeostasis
(Thesis) Arguer
 Tiago Jorge Monteiro Brás (PhD)
Universidade do Minho Escola de Medicina, Portugal
2021/03/24 Development of a novel nanoparticle-antibody based product for the detection of Mycobacterium tuberculosis by "lab-on-chip" diagnostic platforms
(Thesis) Arguer
 Teresa Raquel Guerra Barroso (PhD)
Universidade do Minho Escola de Medicina, Portugal
2020/09/02 Characterization of CD8 tissue-resident memory T cells in the salivary gland and the impact of MCMV infection on T cell recruitment and retention
(Thesis) Arguer
 Sofia Caldeira Dantas (PhD)
Universidade do Minho Escola de Medicina, Portugal
2020/03/04 Impact of host glycosylation in tuberculosis
(Thesis) Main arguer
 Kaori Levy da Fonseca (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/10/04 Development of a Lassa/Rabies virus vaccine based on the Rabies vector
(Thesis) Arguer
 Tiago José Abreu Mota (PhD)
Universidade do Minho Escola de Medicina, Portugal
2019/09/10 Homeostasis and response of IL-17-producing gd T cells in peripheral tissues
(Thesis) Main arguer
 Pedro Henrique Papotto Rosa (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018/07/19 Impact of regulatory cytokines in hematopoiesis
(Thesis) Arguer
 Ana Catarina Matos Cardoso da Silva (PhD)
Universidade do Minho Escola de Medicina, Portugal

Committee member

Activity description
Role 		Institution / Organization
2023/09/01 - Current National Immunization Technical Advisory Group (Comissão Técnica de Vacinação)
Member
 Direcção-Geral da Saúde, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2014/09/01 - Current Fundamentals in Immunology and Infection (Pós-Graduação) Universidade do Minho Escola de Medicina, Portugal
2014/09/01 - Current Microbiology and Immunology medicine (Licenciatura) Universidade do Minho Escola de Medicina, Portugal
Distinctions

Award

2023 SPI best paper award 2023
Sociedade Portuguesa de Imunologia, Portugal
2021 Best oral presentation award
Sociedade Portuguesa de Imunologia, Portugal
2017 Best Poster
2017 Best Poster
Sociedade Portuguesa de Imunologia, Portugal
2016 Robalo Cordeiro Prize SPP/Novartis 2016
Sociedade Portuguesa de Pneumologia, Portugal
2015 Best oral presentation award
2012 AAI Young Investigator Award
American Association of Immunologists Inc, United States
2010 Pulido Valente Prize in Science
Fundação Professor Francisco Pulido Valente, Portugal
2010 SPI Best Paper Award 2010
Sociedade Portuguesa de Imunologia, Portugal
2006 Best Poster
2006 Excellence in Immunology prize
Sociedade Portuguesa de Imunologia, Portugal

Other distinction

2019 IACOBUS Fellowship
2018 IACOBUS Fellowship
2016 Fellowship Liga Portuguesa Contra o Cancro/ANA Aeroportos de Portugal
Liga Portuguesa Contra o Cancro, Portugal
2014 FCT investigator
Fundação para a Ciência e a Tecnologia, Portugal
2003 PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal