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Maria Margarida Souto Carneiro. Concluiu a Licenciatura em Bioquímica em 1997 pela Universidade de Lisboa, Faculdade de Ciências e o "Doktorgrad" em 2000/10/13 pela Julius-Maximilians-Universität Würzburg, Fakultät für Biologie. É Investigadora principal (carreira) na Universitätsklinikum Heidelberg Abteilung Innere Medizin V Hämatologie Onkologie Rheumatologie e Professora Auxiliar na UniversitatsKlinikum Heidelberg Institut fur Immunologie. Publicou 33 artigos em revistas especializadas. Orientou 1 tese de doutoramento. Orientou 2 dissertações de mestrado. Recebeu 3 prémios e/ou homenagens. Participou como Investigadora Principal/Responsável em 4 projetos e colaborou em 1 projeto como Investigadora. Atua na(s) área(s) de Ciências Médicas e da Saúde com ênfase em Medicina Básica com ênfase em Imunologia e Ciências Médicas e da Saúde com ênfase em Medicina Clínica/Reumatologia. Nas suas atividades profissionais interagiu com 168 colaborador(es) em coautorias de trabalhos científicos. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: CD8 T cells; metabolism; immune-checkpoint inhibitors; melanoma; inflammation; JAK/STAT pathway; metabolomics; lipidomics; biomarkers; flow-cytometry; B cells; immunometabolism; biomarker discovery; chronic inflammation; .
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Identification

Personal identification

Full name
Maria Margarida Souto Carneiro

Citation names

  • Souto-Carneiro, Margarida

Author identifiers

Ciência ID
C91C-8738-0746
ORCID iD
0000-0001-6923-0590

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Clinical Medicine - Rheumatology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
German (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Advanced (C1) Intermediate (B1)
Education
Degree Classification
1997/10/15 - 2000/10/13
Concluded
 Doutoramento (Doktorgrad)
Major in Immunologia
Julius-Maximilians-Universität Würzburg Fakultät für Biologie, Germany
"Molecular and functional analysis of human synovial B-lymphocytes in rheumatoid arthritis" (THESIS/DISSERTATION)
 Very Good (Sehr Gut)
1997
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Influence of gld and lpr mutations on the development of CIA in C57/BL6 mice" (THESIS/DISSERTATION)
 15 valores
Affiliation

Science

Category
Host institution 		Employer
2014/09/01 - Current Principal Investigator (Research) Universitätsklinikum Heidelberg Abteilung Innere Medizin V Hämatologie Onkologie Rheumatologie, Germany
2009/04/01 - 2016/09/30 Auxiliary Researcher (Research) CNC.IBILI, Portugal
2008/09/01 - 2009/03/31 Visiting Researcher (Research) Instituto de Medicina Molecular, Portugal
2004/10/01 - 2008/08/31 Researcher (Research) Instituto Gulbenkian de Ciência, Portugal
2001/02/10 - 2004/05/31 Postdoc (Research) National Institutes of Health, United States
1997/10/15 - 2000/12/31 Research Assistant (Research) Julius-Maximilians-Universität Würzburg Institut für Pathologie, Germany

Teaching in Higher Education

Category
Host institution 		Employer
2018/04/17 - Current Assistant Professor (University Teacher) UniversitatsKlinikum Heidelberg Institut fur Immunologie, Germany
2004/10/15 - 2005/02/28 Invited Assistant Professor (University Teacher) Universidade de Évora, Portugal
Projects

Grant

Designation Funders
2021/10/15 - 2023/03/15 Serum metabolomic signature and IL-1.associated cytokines as predictive biomarkers for immune-checkpoint inhibitor therapy-associated immune-related adverse events in NSCLC
CUNO525926
Principal investigator
Ruprecht Karls Universität Heidelberg, Germany
 Novartis Pharma GmbH
Ongoing
2015/12 - 2016/12 Influence of Parkinson’s disease LRRK2-mutation in the titers and avidity indexes of naturally-occurring IgG anti-SNCA antibodies
6583.02
Principal investigator
Michael J Fox Foundation for Parkinson's Research
2011 - 2014 LRRK2 Role on Auto-Antibody Production by Human B Cells
6583.01
6583
 Michael J Fox Foundation for Parkinson's Research
2009/06 - 2012/05 The role of reactive oxygen species in B cell tolerization and immune memory
239422
 European Commission
2007/07 - 2010/07 Effects of inflammation on bone and cartilage: collagen pattern and biomechanical properties
Provided by PTCRIS: 65992
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2006/08 - 2008/07 Cellular and molecular dynamics of ectopic germinal centre formation in rheumatoid arthritis
25885
 European Commission

Contract

Designation Funders
2019/09/15 - Current Flow cytometry core unit (Z02)
122491522
Researcher
Universitätsklinikum Heidelberg Abteilung Innere Medizin V Hämatologie Onkologie Rheumatologie, Germany
 Deutsche Forschungsgemeinschaft
Ongoing
2016/01 - Current Metabolic processes in rheumatoid arthritis CD8+T cells: exploring their diagnostic value and potential as therapeutic targets
299146739
Principal investigator
Universitätsklinikum Heidelberg Abteilung Innere Medizin V Hämatologie Onkologie Rheumatologie, Germany
 Deutsche Forschungsgemeinschaft
Ongoing
2019/10/15 - 2022/08/01 Effects of Tofacitinib on cytotoxic T lymphocytes from patients developing rheumatoid and psoriatic arthritis induced by therapy with immune-checkpoint inhibitors
WI245418
Principal investigator
Universitätsklinikum Heidelberg Abteilung Innere Medizin V Hämatologie Onkologie Rheumatologie, Germany
 Pfizer AG
Ongoing
2019/12/18 - 2020/11/30 Metabolic signature in cancer patients with inflammatory rheumatic diseases
2019-135349
Principal investigator
Universitätsklinikum Heidelberg Abteilung Innere Medizin V Hämatologie Onkologie Rheumatologie, Germany
 Ruprecht Karls Universität Heidelberg
Ongoing
Outputs

Publications

Journal article
  1. M. Margarida Souto-Carneiro; Karel D. Klika; Mónica T. Abreu; André P. Meyer; Rainer Saffrich; Roger Sandhoff; Richard Jennemann; et al. "Effect of Increased Lactate Dehydrogenase A Activity and Aerobic Glycolysis on the Proinflammatory Profile of Autoimmune CD8+ T Cells in Rheumatoid Arthritis". Arthritis & Rheumatology (2020): https://doi.org/10.1002/art.41420.
    10.1002/art.41420
  2. Souto-Carneiro, Margarida; Tóth, Lilla; Behnisch, Rouven; Urbach, Konstantin; Klika, Karel D; Carvalho, Rui A; Lorenz, Hanns-Martin. "Differences in the serum metabolome and lipidome identify potential biomarkers for seronegative rheumatoid arthritis versus psoriatic arthritis". Annals of the Rheumatic Diseases 79 4 (2020): 499-506. http://dx.doi.org/10.1136/annrheumdis-2019-216374.
    Open access • Published • 10.1136/annrheumdis-2019-216374
  3. Carvalho, Lina; Gomes, Joana R. M.; Tavares, Ludgero C.; Xavier, Ana R.; Klika, Karel D.; Holmdahl, Rikard; Carvalho, Rui A.; Souto-Carneiro, M. Margarida. "Reactive Oxygen Species Deficiency Due to Ncf1-Mutation Leads to Development of Adenocarcinoma and Metabolomic and Lipidomic Remodeling in a New Mouse Model of Dextran Sulfate Sodium-Induced Colitis". Frontiers in Immunology 9 (2018): http://dx.doi.org/10.3389/fimmu.2018.00701.
    Published • 10.3389/fimmu.2018.00701
  4. Tucher, Christine; Bode, Konrad; Schiller, Petra; Claßen, Laura; Birr, Carolin; Souto-Carneiro, Maria Margarida; Blank, Norbert; Lorenz, Hanns-Martin; Schiller, Martin. "Extracellular Vesicle Subtypes Released From Activated or Apoptotic T-Lymphocytes Carry a Specific and Stimulus-Dependent Protein Cargo". Frontiers in Immunology 9 (2018): http://dx.doi.org/10.3389/fimmu.2018.00534.
    10.3389/fimmu.2018.00534
  5. Souto-Carneiro MM; Lorenz HM. "Reply: To PMID 25370956.". (2015): http://europepmc.org/abstract/med/25940781.
    10.1002/art.39180
  6. Henriques A; Silva I; Inês L; Souto-Carneiro MM; Pais ML; Trindade H; da Silva JA; Paiva A. "CD38, CD81 and BAFFR combined expression by transitional B cells distinguishes active from inactive systemic lupus erythematosus.". (2015): http://europepmc.org/abstract/med/25894569.
    10.1007/s10238-015-0348-3
  7. Carvalheiro H; Duarte C; Silva-Cardoso S; daSilva JA; Souto-Carneiro MM. "CD8(+) T cell profiles in patients with rheumatoid arthritis and their relationship to disease activity.". (2014): http://europepmc.org/abstract/med/25370956.
    10.1002/art.38941
  8. MM Souto-Carneiro. "Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice". PLoS One (2014):
    10.1371/journal.pone.0097532
  9. MM Souto-Carneiro. "Reactive oxygen species deficiency induces autoimmunity with downstream interferon signature.". Antioxid Redox Signal. (2014): http://online.liebertpub.com/doi/abs/10.1089/ars.2013.5828.
    10.1089/ars.2013.5828
  10. MM Souto-Carneiro. "Alterations in the peripheral blood B cell subpopulations of multidrug-resistant tuberculosis patients.". Clin Exp Med. (2013): http://link.springer.com/article/10.1007%2Fs10238-013-0258-1.
    10.1007/s10238-013-0258-1
  11. Carvalheiro, H.; da Silva, J.A.P.; Souto-Carneiro, M.M.. "Potential roles for CD8+ T cells in rheumatoid arthritis". Autoimmunity Reviews 12 3 (2013): 401-409. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872386275&partnerID=MN8TOARS.
    10.1016/j.autrev.2012.07.011
  12. Moura, R.A.; Cascão, R.; Perpétuo, I.; Canhão, H.; Vieira-sousa, E.; Mourão, A.F.; Rodrigues, A.M.; et al. "Cytokine pattern in very early rheumatoid arthritis favours B-cell activation and survival". Rheumatology 50 2 (2011): 278-282. http://www.scopus.com/inward/record.url?eid=2-s2.0-78751692218&partnerID=MN8TOARS.
    10.1093/rheumatology/keq338
  13. Moura RA; Cascão R; Perpétuo I; Canhão H; Vieira de Sousa E; Mourão AF; Rodrigues AM; et al. "Spondyloarthropathy and rheumatoid arthritis: two different diseases, a similar cytokine network.". (2010): http://europepmc.org/abstract/PMC/PMC3007780.
  14. Cascão, R.; Moura, R.A.; Perpétuo, I.; Canhão, H.; Vieira-Sousa, E.; Mourão, A.F.; Rodrigues, A.M.; et al. "Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis". Arthritis Research and Therapy 12 5 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77958006636&partnerID=MN8TOARS.
    10.1186/ar3168
  15. Raposo, B.R.; Rodrigues-Santos, P.; Carvalheiro, H.; Água-Doce, A.M.; Carvalho, L.; Pereira Da Silva, J.A.; Graça, L.; Souto-Carneiro, M.M.. "Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis". Arthritis and Rheumatism 62 10 (2010): 2953-2962. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957678588&partnerID=MN8TOARS.
    10.1002/art.27729
  16. Cascão, R.; Rosário, H.S.; Souto-Carneiro, M.M.; Fonseca, J.E.. "Neutrophils in rheumatoid arthritis: More than simple final effectors". Autoimmunity Reviews 9 8 (2010): 531-535. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952742498&partnerID=MN8TOARS.
    10.1016/j.autrev.2009.12.013
  17. Moura, R.A.; Weinmann, P.; Pereira, P.A.; Caetano-Lopes, J.; Canhão, H.; Sousa, E.; Mourão, A.F.; et al. "Alterations on peripheral blood B-cell subpopulations in very early arthritis patients". Rheumatology 49 6 (2010): 1082-1092. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953487867&partnerID=MN8TOARS.
    10.1093/rheumatology/keq029
  18. Cascão R; Moura RA; Perpétuo I; Canhão H; Vieira de Sousa E; Mourão AF; Rodrigues AM; et al. "Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis.". (2010): http://europepmc.org/abstract/PMC/PMC3007778.
  19. Moura RA; Cascão R; Perpétuo I; Canhão H; Vieira de Sousa E; Mourão AF; Rodrigues AM; et al. "Cytokine pattern in very early rheumatoid arthritis favours B cell activation and survival.". (2010): http://europepmc.org/abstract/PMC/PMC3007777.
  20. Caetano-Lopes J; Nery AM; Henriques R; Canhão H; Duarte J; Amaral PM; Vale M; et al. "Chronic arthritis directly induces quantitative and qualitative bone disturbances leading to compromised biomechanical properties.". (2009): http://europepmc.org/abstract/med/19604441.
  21. Souto-Carneiro, M.M.; Mahadevan, V.; Takada, K.; Fritsch-Stork, R.; Nanki, T.; Brown, M.; Fleisher, T.A.; et al. "Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor". Arthritis Research and Therapy 11 3 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-67649472564&partnerID=MN8TOARS.
    10.1186/ar2718
  22. Caetano-Lopes, J.; Nery, A.M.; Henriques, R.; Canhão, H.; Duarte, J.; Amaral, P.M.; Vale, M.; et al. "Chronic arthritis directly induces quantitative and qualitative bone disturbances leading to compromised biomechanical properties". Clinical and Experimental Rheumatology 27 3 (2009): 475-482. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349116274&partnerID=MN8TOARS.
  23. Souto-Carneiro MM; Fritsch R; Sepúlveda N; Lagareiro MJ; Morgado N; Longo NS; Lipsky PE. "The NF-kappaB canonical pathway is involved in the control of the exonucleolytic processing of coding ends during V(D)J recombination.". (2008): http://europepmc.org/abstract/med/18178844.
    10.4049/jimmunol.180.2.1040
  24. Souto-Carneiro, M.M.; Fritsch, R.; Sepúlveda, N.; Lagareiro, M.J.; Morgado, N.; Longo, N.S.; Lipsky, P.E.. "The NF-¿B canonical pathway is involved in the control of the exonucleolytic processing of coding ends during V(D)J recombination". Journal of Immunology 180 2 (2008): 1040-1049. http://www.scopus.com/inward/record.url?eid=2-s2.0-40449110380&partnerID=MN8TOARS.
  25. Souto-Carneiro, M.M.; Zouali, M.. "Highlights of Mediterranean clinical immunology". Immunology Letters 110 1 (2007): 18-22. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247623155&partnerID=MN8TOARS.
    10.1016/j.imlet.2007.03.003
  26. Bleesing JJ; Souto-Carneiro MM; Savage WJ; Brown MR; Martinez C; Yavuz S; Brenner S; et al. "Patients with chronic granulomatous disease have a reduced peripheral blood memory B cell compartment.". (2006): http://europepmc.org/abstract/med/16709872.
    10.4049/jimmunol.176.11.7096
  27. Bleesing, J.J.; Souto-Carneiro, M.M.; Savage, W.J.; Brown, M.R.; Martinez, C.; Yavuz, S.; Brenner, S.; et al. "Patients with chronic granulomatous disease have a reduced peripheral blood memory B cell compartment". Journal of Immunology 176 11 (2006): 7096-7103. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646881800&partnerID=MN8TOARS.
  28. Souto-Carneiro MM; Sims GP; Girschik H; Lee J; Lipsky PE. "Developmental changes in the human heavy chain CDR3.". (2005): http://europepmc.org/abstract/med/16301650.
    10.4049/jimmunol.175.11.7425
  29. Souto-Carneiro, M.M.; Sims, G.P.; Girschik, H.; Lee, J.; Lipsky, P.E.. "Developmental changes in the human heavy chain CDR3". Journal of Immunology 175 11 (2005): 7425-7436. http://www.scopus.com/inward/record.url?eid=2-s2.0-28244447463&partnerID=MN8TOARS.
  30. Souto-Carneiro MM; Longo NS; Russ DE; Sun HW; Lipsky PE. "Characterization of the human Ig heavy chain antigen binding complementarity determining region 3 using a newly developed software algorithm, JOINSOLVER.". (2004): http://europepmc.org/abstract/med/15153497.
    10.4049/jimmunol.172.11.6790
  31. Souto-Carneiro, M.M.; Longo, N.S.; Russ, D.E.; Sun, H.-W.; Lipsky, P.E.. "Characterization of the human Ig heavy chain antigen binding complementarity determining region 3 using a newly developed software algorithm, JOINSOLVER". Journal of Immunology 172 11 (2004): 6790-6802. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442717677&partnerID=MN8TOARS.
  32. Magalhães R; Gehrke T; Souto-Carneiro MM; Kriegsmann J; Krenn V. "Extensive plasma cell infiltration with crystal IgG inclusions and mutated IgV(H) gene in an osteoarthritis patient with lymphoplasmacellular synovitis. A case report.". (2002): http://europepmc.org/abstract/med/11866210.
    10.1078/0344-0338-00183
  33. Magalhães, R.; Gehrke, T.; Souto-Carneiro, M.M.; Kriegsmann, J.; Krenn, V.. "Extensive plasma cell infiltration with crystal IgG inclusions and mutated IgV H gene in an osteoarthritis patient with lymphoplasmacellular synovitis. A case report". Pathology Research and Practice 198 1 (2002): 45-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036175785&partnerID=MN8TOARS.
  34. Souto-Carneiro MM; Burkhardt H; Müller EC; Hermann R; Otto A; Kraetsch HG; Sack U; et al. "Human monoclonal rheumatoid synovial B lymphocyte hybridoma with a new disease-related specificity for cartilage oligomeric matrix protein.". (2001): http://europepmc.org/abstract/med/11238672.
    10.4049/jimmunol.166.6.4202
  35. Souto-Carneiro, M.M.; Burkhardt, H.; Müller, E.C.; Hermann, R.; Otto, A.; Kraetsch, H.-G.; Sack, U.; et al. "Human monoclonal rheumatoid synovial B lymphocyte hybridoma with a new disease-related specificity for cartilage oligomeric matrix protein". Journal of Immunology 166 6 (2001): 4202-4208. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035869603&partnerID=MN8TOARS.
  36. Hermann R; Hensel F; Müller EC; Keppler M; Souto-Carneiro M; Brändlein S; Müller-Hermelink HK; Vollmers HP. "Deactivation of regulatory proteins hnRNP A1 and A2 during SC-1 induced apoptosis.". (2001): http://europepmc.org/abstract/med/11673663.
  37. Hermann, R.; Hensel, F.; Müller, E.-C.; Keppler, M.; Souto-Carneiro, M.; Brändlein, S.; Müller-Hermelink, H.K.; Peter Vollmers, H.. "Deactivation of regulatory proteins hnRNP A1 and A2 during SC-1 induced apoptosis". Human Antibodies 10 2 (2001): 83-90. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034774984&partnerID=MN8TOARS.
  38. Krenn V; Souto-Carneiro MM; Kim HJ; Berek C; Starostik P; König A; Harms H; Müller-Hermelink HK. "Histopathology and molecular pathology of synovial B-lymphocytes in rheumatoid arthritis.". (2000): http://europepmc.org/abstract/med/10963123.
  39. Souto-Carneiro, M.M.; Krenn, V.; Hermann, R.; König, A.; Müller-Hermelink, H.-K.. "IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation process". Arthritis Research 2 4 (2000): 303-314. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034468363&partnerID=MN8TOARS.
    10.1186/ar105
  40. Krenn, V.; Souto-Carneiro, M.M.; Kim, H.-J.; Berek, C.; Starostik, P.; Konig, A.; Harms, H.; Muller-Hermelink, H.K.. "Histopathology and molecular pathology of synovial B-lymphocytes in rheumatoid arthritis". Histology and Histopathology 15 3 (2000): 791-798. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033913994&partnerID=MN8TOARS.
  41. Krenn V; Hensel F; Kim HJ; Souto Carneiro MM; Starostik P; Ristow G; König A; Vollmers HP; Müller-Hermelink HK. "Molecular IgV(H) analysis demonstrates highly somatic mutated B cells in synovialitis of osteoarthritis: a degenerative disease is associated with a specific, not locally generated immune response.". Laboratory investigation; a journal of technical methods and pathology (1999): http://europepmc.org/abstract/med/10576208.
  42. Krenn, V.; Hensel, F.; Kim, H.-J.; Souto Carneiro, M.M.; Starostik, P.; Ristow, G.; König, A.; Vollmers, H.P.; Müller-Hermelink, H.K.. "Molecular IgV(H) analysis demonstrates highly somatic mutated B cells in synovialitis of osteoarthritis: A degenerative disease is associated with a specific, not locally generated immune response". Laboratory Investigation 79 11 (1999): 1377-1384. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032708154&partnerID=MN8TOARS.
  43. Krenn, V.; König, A.; Hensel, F.; Berek, C.; Souto Carneiro, M.M.; Haedicke, W.; Wang, Y.K.; Vollmers, H.-P.; Müller-Hermelink, H.K.. "Molecular analysis of rheumatoid factor (RF)-negative B cell hybridomas from rheumatoid synovial tissue: Evidence for an antigen-induced stimulation with selection of high mutated IgV(H) and low mutated IgV(L)/¿ genes". Clinical and Experimental Immunology 115 1 (1999): 168-175. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032943626&partnerID=MN8TOARS.
    10.1046/j.1365-2249.1999.00767.x
  44. Souto-Carneiro MM; Krenn V; Hermann R; Ristow G; König A; Müller-Hermelink HK. "[Mutational pattern of Ig-VH genes of synovial B-lymphocytes from different anatomical locations in a rheumatoid arthritis patient]". (1999): http://europepmc.org/abstract/med/10714220.
  45. Souto-Carneiro, M.M.; Krenn, V.; Hermann, R.; Ristow, G.; König, A.; Müller-Hermelink, H.K.. "Mutational pattern of Ig-VH genes of synovial B-lymphocytes from different anatomical locations in a rheumatoid arthritis patient | Mutationsmuster der Ig-VH-Gene von synovialen B-Lymphozyten aus verschiedenen anatomischen Lokalisationen eines rheumatoiden Arthritis Patienten.". Verhandlungen der Deutschen Gesellschaft fur Pathologie 83 (1999): 260-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033251065&partnerID=MN8TOARS.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2009/05/02 - 2014/11/05 The role of CD8+ T cells in the pathogenesis of rheumatoid arthritis;
Supervisor
 Ciências Farmacêuticas (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2014 DSS induced colitis in NCf1-mutated mice
Supervisor
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 - 2014 DSS induced colitis in Nef1-mutated mice leading to adenocarcinoma: therapeutic strategies
Supervisor
 Biologia Humana e Ambiente (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
Distinctions

Award

2005 Young Investigator Award
European League Against Rheumatism, Switzerland
2001 Scientific Presentation Excellence Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases, United States
1999 2nd Poster Prize
Deutsche Gesellschaft für Pathologie, Germany