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Bruno Pereira is an Associate Researcher (CEECINST/00131/2021) and Project Leader at i3S in the Differentiation and Cancer group, with an independent research line focused on the role of RNA-binding protein (RBP) networks in intestinal homeostasis and carcinogenesis. He leads a team of 3 PhD students and 1 MSc student. He did a PhD in Biomedicine (2013) from the Faculty of Medicine, University of Porto (FMUP) studying the regulation of the intestinal transcription factor CDX2 in cancer, in Almeida's lab at IPATIMUP and Billaud's lab at the Institute for Advanced Biosciences (IAB, Grenoble, France). As a major finding, he showed that the novel RBP MEX3A represses CDX2 expression and intestinal differentiation (Nucleic Acids Research, 2013). Still in 2013, he was invited to represent FMUP at the 10th International Medical Postgraduate Conference (Hradec Králové, Czech Republic), where he was recognized by the Organisation for PhD Education in Biomedicine and Health Sciences in the European System (ORPHEUS) with an Outstanding Research award. His postdoc studies began in 2014 with an EMBO Fellowship at IAB (France), where he acquired expertise in confocal microscopy techniques of 3D cell culture systems. After returning to Portugal, he gained competences in animal experimentation (FELASA C certification) and acted as co-PI in a highly competitive EU FP7 INFRAFRONTIER-I3 call (only 30 projects funded) to generate the first Mex3a knockout (KO) mouse model for human oncopathology studies. In 2016, he was awarded a Postdoctoral fellowship in the national FCT Call and nominated member of the i3S Animal Welfare and Ethics Review Body (ORBEA) to improve the quality of animal experimentation. In the following 3 years, he characterised the KO mouse phenotype and in collaboration with Gijs van de Brink and Vanesa Muncan (Amsterdam UMC, the Netherlands) became proficient in the use of organoids as experimental models. This led to uncover MEX3A as a new functional marker of intestinal stem cells (EMBO Reports, 2020), a high impact work featured on the journal`s cover. Moreover, he has published a highly cited review on the interplay between RBPs and cancer (Trends in Cancer, 2017). In 2018 he was awarded a CEEC Junior Researcher contract and in 2023 a CEEC Associate Researcher contract. Bruno Pereira has a strong record in the stem cell and cancer fields, with 15 publications, 6 as first author and 4 as corresponding author (h-index 12, > 950 citations) and 2 book chapters. His work has been shown in over 50 specialized meetings (including 20 oral presentations, 7 by invitation and 34 conference posters) and credited with several awards, including the Crioestaminal & SPCE-TC (Portuguese Society of Stem Cells and Cell Therapies) Regenerative Medicine Research award in 2022. Since 2018, he has consistently secured funding (€450k total) as a leading PI in highly competitive calls from both national (FCT grants: inSTEM, PTDC/BIA-MOL/31538/2017; diffNET, PTDC/BIA-CEL/0456/2021) and international (MERCK: ResistNET, Biopharma Speed grant:) funding agencies. He successfully supervised 2 postdocs and 12 MSc thesis. He acts as an invited evaluator for national/international grants, including Worldwide Cancer Research, and has editorial roles in journals (Review Editor for Frontiers in Cell and Developmental Biology; Guest Editor for the JoVE Methods Collection "Guts out: stem cell-derived 3D approaches to study intestinal homeostasis and disease ex vivo"). He is an active member of relevant societies in his field of expertise, including the Portuguese (ASPIC) and European (EACR) Associations for Cancer Research. He is currently the President of the Portuguese Association of Science and Technology Researchers (ANICT), advocating for better science policies through constructive dialogue with policymakers and all stakeholders in the national scientific system.
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Identification

Personal identification

Full name
Bruno Miguel Correia Pereira
Gender
Male

Citation names

  • Pereira, B.

Author identifiers

Ciência ID
CA1A-E79D-A273
ORCID iD
0000-0003-2460-6720
Researcher Id
H-5614-2019
Scopus Author Id
55578807657

Email addresses

  • bpereira@ipatimup.pt (Professional)

Telephones

Telephone
  • 226074900 Ext.: 6115 (Professional)

Addresses

  • i3S - Institute for Research and Innovation in Health (Instituto de Investigação e Inovação em Saúde), University of Porto. Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Basic Medicine
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2014
Concluded
 Postgraduate course in Laboratory Animal Science (FELASA category C) (Pós-Graduação)
Institute for Molecular and Cell Biology (IBMC), Portugal
2009/11/23 - 2013/11/18
Concluded
 Biomedicine, PhD (Doutoramento)
Faculty of Medicine of the University of Porto, Portugal
"Regulation of CDX2 and intestinal differentiation in homeostasis and carcinogenesis: emphasis on MEX3A role" (THESIS/DISSERTATION)
 Approved by unanimity with distinction
2009
Concluded
 Postgraduate course in English (Effective Operational Proficiency) (Pós-Graduação)
Major in C1 level
Faculty of Arts and Humanities of University of Porto, Portugal
 18 (out of 20)
2008
Concluded
 Postgraduate course in Animal Cell and Tissue Culture: from basic principles to advanced techniques (Pós-Graduação)
Life and Health Sciences Research Institute (ICVS), University of Minho, Portugal
2002/09/26 - 2006/09/15
Concluded
 Biology, BSc (Licenciatura)
Faculty of Sciences of the University of Porto, Portugal
"Mitochondrial disfunctions motivated by alterations in the respiratory chain in Neurospora crassa" (THESIS/DISSERTATION)
 15 (out of 20)
Affiliation

Science

Category
Host institution 		Employer
2023/01/01 - Current Researcher (Research) Institute for Research and Innovation in Health, University of Porto (i3S) - Associate Researcher, Portugal
i3S, University of Porto, Portugal
2019/01/01 - 2022/12/31 Researcher (Research) Institute for Research and Innovation in Health, University of Porto (i3S) - Junior Researcher, Portugal
IPATIMUP, Portugal
2013/11/19 - 2018/12/31 Postdoc (Research) Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) - Postdoctoral fellow (NORTE-07-0124-FEDER-000024 and Incentivo/SAU/LA0003/2014; SFRH/BPD/109794/2015, FCT), Portugal
IPATIMUP, Portugal
2014/01/06 - 2014/03/18 Postdoc (Research) Institute for Advanced Biosciences (IAB) - EMBO Short Term fellowship (ASTF 280-2013), France
Institut pour l'Avancée des Biosciences, France
2009/02/02 - 2013/02/01 Researcher (Research) IPATIMUP - Doctoral degree fellow (SFRH/BD/43168/2008, FCT), Portugal
2012/03/01 - 2012/06/10 Visiting Researcher (Research) IAB - Visiting PhD student, France
2007/04/02 - 2008/06/30 Research Trainee (Research) IPATIMUP - Research fellow (POCI/SAU-OBS/55840/2004, FCT), Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2006/02/01 - 2007/03/30 Research Trainee (Research) Institute for Molecular and Cell Biology (IBMC) - Undergraduate trainee fellow (POCI/N/07.01.02/0232/0030/2005, FCT), Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Projects

Grant

Designation Funders
2024/01/15 - Current IronCell2Cell - The macrophage-hepatocyte iron communication during Mycobacterial infection (Team member)
2022.03635.PTDC
10.54499/2022.03635.PTDC
Researcher
Universidade de Lisboa Instituto Dom Luiz, Portugal

Instituto de Astrofísica e Ciências do Espaço, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/12/01 - Current diffNET - Restoring differentiation in cancer cells by manipulating RNA-binding protein NETworks (Principal Investigator)
PTDC/BIA-CEL/0456/2021
Principal investigator
i3S, University of Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2024 ResistNET - Identifying RNA-binding proteins mediating therapy resistance regulatory networks in cancer (Principal Investigator)
Biopharma Speed Grant - Oncology
Principal investigator
i3S, University of Porto, Portugal
 Merck KGaA
Concluded
2018/07/01 - 2021/12/31 ReProgram: Reconstructing the Program of Cancer Stem Cells (Team member)
POCI-01-0145-FEDER-029017
Researcher
IPATIMUP, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017/01/01 - 2021/06/30 Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy (Team member)
SAICTPAC/0022/2015
Researcher
IPATIMUP, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/07/01 - 2021/04/30 inSTEM - a novel post-transcriptional regulatory network controlling intestinal stem cells fate (Principal Investigator)
PTDC/BIA-MOL/31538/2017
Principal investigator
IPATIMUP, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/05/01 - 2018/12/31 SOX2-mediated tumor heterogeneity and novel therapeutic strategies targeting cancer stem cells/relevance of tumor heterogeneity for development of strategies to inhibit peritoneal carcinomatosis (Team member)
NORTE-01-0145-FEDER-000029
Post-doc Fellow
IPATIMUP, Portugal
 NORTE2020
Concluded
2013/12/01 - 2014/07/01 Modulation of CDX2 expression in gastric intestinal metaplasia using an siRNA delivery system in vivo (Team member)
SPG
Post-doc Fellow
IPATIMUP, Portugal
 Portuguese Society of Gastroenterology (Sociedade Portuguesa de Gastrenterologia - SPG)
Concluded
2005/07/01 - 2008/06/30 Identification of signaling pathways involved in Cdx2 regulation in two human models of altered intestinal differentiation: intestinal metaplasia and juvenile polyposis (Hired team member)
info:eu-repo/grantAgreement/FCT/POCI/55840/PT
Integration into Research Grant Fellow
IPATIMUP, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023/01/01 - Current diffNET - Restoring differentiation in cancer cells by manipulating RNA-binding protein NETworks (Associate Researcher)
CEECINST/00131/2021/CP2805/CT0002
Researcher
i3S, University of Porto, Portugal

IPATIMUP, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/04/01 - 2022/12/31 inSTEM - A novel post-transcriptional regulatory network controlling intestinal stem cell fate (Junior researcher)
CEECIND/03235/2017/CP1400/CT0007
Researcher
IPATIMUP, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Institute for Research and Innovation in Health Sciences
UID/BIM/04293/2019
LA/P/0070/2020
10.54499/LA/P/0070/2020
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/01/01 - 2019/12/31 Integrating Metabolic and Polarity Alterations in Cancer by post-transcriptional modulation of the LKB1-AMPK-mTOR axis (IMPACTOR): the role of MEX3A (Post-doc)
SFRH/BPD/109794/2015
Post-doc Fellow
IPATIMUP, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/04/30 - 2015/06/30 Differentiation in cancer with emphasis on glycoproteome alterations (Post-doc)
NORTE – 07-0124-FEDER-000024
Incentivo/SAU/LA0003/2014
Post-doc Fellow
IPATIMUP, Portugal
 Programa Operacional Regional do Norte - ON.2
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 3 - 2011-2012
PEst-C/SAU/LA0003/2011
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/04/02 - 2008/06/30 Identification of signaling pathways involved in Cdx2 regulation in two human models of altered intestinal differentiation: intestinal metaplasia and juvenile polyposis
POCI/SAU-OBS/55840/2004
Integration into Research Grant Fellow
IPATIMUP, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2014 - 2015 Generation of a Mex3a knockout mouse model for functional analysis of human diseases (co-Principal Investigator)
EC FP7 INFRAFRONTIER-I3 - EU contract Grant Agreement Number 312325
Other
IPATIMUP, Portugal
 Infrafrontier Research Infrastructure
Concluded
Outputs

Publications

Book chapter
  1. Pereira, B.. "Organoid-based models for permeability studies". In Concepts and Models for Drug Permeability Studies: Cell and Tissue based In Vitro Culture Models, 1-500. Elsevier, 2024.
    In press
  2. Bebiano, Luís B.; Castro, Flávia; Ethan Li, Yi-Chen; Pereira, B.; Pereira, Rúben F.. "Bioprinting Biomimetic 3D Constructs for Tissue Modelling and Repair". In Emerging Drug Delivery and Biomedical Engineering Technologies, 49-70. CRC Press, 2023.
    10.1201/9781003224464-4
Conference abstract
  1. de Oliveira, Catarina V.; Ferreira, Diana; Luis F.C. Póvoas; Valentini, Elvia; Mesquita, Patricia; Pereira, B.; Jerónimo, Carmen; Almeida, Raquel. "Reading between the strands: the role of YTHDF3 in gastric cancer characterization". Paper presented in EMBO Workshop: The Epitranscriptome, (cancelled due to COVID-19), 2021.
Conference poster
  1. Coelho, A.; Machado, V.; Vasconcelos, M.H.; Almeida, R.; Pereira, B.. "Establishment and characterization of colorectal cancer oxaliplatin-resistant tumoroids to study chemotherapy resistance". Paper presented in 6th ASPIC International Congress, 2024.
  2. Coelho, A.; Machado, V.; Vasconcelos, M.H.; Almeida, R.; Pereira, B.. "Establishment and characterization of colorectal cancer oxaliplatin-resistant tumoroids for the study of RNA-binding proteins mediating therapy resistance". Paper presented in 30th Porto Cancer Meeting - RNA biology in cancer: fundamentals and clinical relevance, 2024.
  3. Mesquita, P.; Coelho, A.; Ribeiro, A.S.; Póvoas, L.F.C.; Silva, S.; Leça, N.; de Oliveira, C.; et al. "YTHDF3 contributes to an aggressive phenotype in gastric cancer". Paper presented in 30th Porto Cancer Meeting - RNA biology in cancer: fundamentals and clinical relevance, 2024.
  4. Silva, AR; Mexieiro, D.; Machado, V.; Russel, M. ; Amaral, A.L.; Almeida, R.; Pereira, B.. "RNA-binding protein MEX3A acts as a PPARG direct regulator with functional impact in colorectal carcinogenesis". Paper presented in European Human Genetics Conference 2023, 2023.
  5. Silva, A.R.; Mexieiro, D.; Machado, V.; Russel, M. ; Amaral., A.L.; Almeida, R.; Pereira, B.. "Functional impact of the RNA-binding protein MEX3A in colorectal carcinogenesis". Paper presented in IX ptRNA - RNA in Disease, 2023.
  6. Coelho, A. ; Almeida, R.; Pereira, B.. "A TIMELESS link between intestinal stem cells and colorectal cancer". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022.
  7. Silva, A.R.; Mexieiro, D.; Amaral, A.L.; Almeida, R.; Pereira, B.. "Functional impact of the intestinal stem cell marker MEX3A in colorectal carcinogenesis". Paper presented in 12th International Meeting of SPCE-TC, 2022.
  8. CV de Oliveira; LFC Póvoas; D Ferreira; D. Pádua; P Mesquita; Pereira, B.; C Jerónimo; R Almeida. Corresponding author: CV de Oliveira. "Epitranscriptomics in gastric cancer: the role of of YTHDF3 in tumor characterization". Paper presented in 27th PORTO CANCER MEETING | Stemness & Metastasis: Advances in Research and Clinical Translation, 2021.
  9. Silva, A.R.; Mexieiro, D.; Amaral, A.L.; Almeida, R.; Pereira, B.. "Functional impact of the intestinal stem cell marker MEX3A in colorectal carcinogenesis". Paper presented in 27th Porto Cancer Meeting, 2021.
  10. Silva, A.R.; Amaral, A.L.; Almeida, R.; Pereira, B.. "MEX3A: an RNA-binding protein with impact in colorectal carcinogenesis". Paper presented in 2nd National meeting of Young Researchers in Oncology, Porto, Portugal, 2020.
  11. Póvoas, L.F.C.; Coelho, R.; Ferreira, D.; Valentini, E.; de Oliveira, C.; Mesquita, P.; Pereira, B.; Almeida, R.. "The epitranscriptome in gastric cancer: the role of m6A mRNA modifications". Paper presented in 13th Meeting of Young Researchers from the University of Porto, Porto, Portugal, 2020.
  12. Póvoas, L.F.C.; de Oliveira, C.V.; Ferreira, D.; Coelho, R.; Mesquita, P.; Pereira, B.; Almeida, R.. "The epitranscriptome in gastric cancer: the role of m6A mRNA modifications". Paper presented in The iMed Conference, Lisboa, Portugal, 2020.
  13. Ferreira, D.; Amaral, A.L.; Valentini, E.; de Oliveira, C.; Póvoas, L.F.C.; Mesquita, P.; Ricardo, C.; Pereira, B.; Almeida, R.. "Identification of new biomarkers in gastric cancer - the role of the epitranscriptome". Paper presented in 15th Young European Scientist (YES) Meeting, Porto, Portugal, 2020.
  14. Dias Carvalho, P.; Carvalho, J.; Martins, F.; Pereira, B.; Velho, S.. "Development of a colon organotypic model to study the role of fibroblasts on cancer initiation: the first steps". Paper presented in Organoids With]Out[ Borders, 2020.
  15. Pereira, B.; Amaral, A.L.; Dias, A.; Mendes, N.; Muncan, V.; Silva, A.R.; Thibert, C.; et al. "Mex3a deletion impairs Lgr5+ stem cell maintenance in the mouse gut". Paper presented in ISSCR International Symposium 2019: Stem cells and Organoids in Development and Disease, Amsterdam, Netherlands, 2019.
  16. Pereira, B.; Amaral, A.L.; Dias, A.; Mendes, N.; Muncan, V.; Silva, A.R.; Thibert, C.; et al. "New signalling pathways for intestinal stem cell identity in development and disease". Paper presented in Goodbye Flat Biology - Advancing 3D-based Models for Cancer Biology and Drug Discovery, Berlin, Germany, 2019.
  17. Dias, A.; Amaral, A.L.; Almeida, R.; Pereira, B.. "Characterization of MEX3A RNA-binding protein in the mouse stomach". Paper presented in VIII National RNA meeting (ptRNA), Porto, Portugal, 2019.
  18. Dias, A.; Amaral, A.L.; Almeida, R.; Pereira, B.. "Characterization of MEX3A RNA-binding protein in the mouse stomach". Paper presented in 7th i3S Annual meeting, Póvoa de Varzim, Portugal, 2018.
  19. Pereira, B.; Amaral, A.L.; Ricardo, S.; van den Brink, G.R.; Billaud, M.; Almeida, R.. "Characterization of a Mex3a knockout mouse model: linking intestinal stem cell homeostasis and cancer". Paper presented in 2nd Portuguese Association for Cancer Research (ASPIC) International Congress, 2016.
  20. Pereira, B.; David, L.; Billaud, M.; Almeida, R.. "Novel dimensions in post-transcriptional regulatory networks: dissecting RNA-binding protein MEX3A functions in gastrointestinal cancer". Paper presented in EACR Conference Series 2014 - Goodbye Flat Biology: 3D Models and the Tumour Microenvironment, Berlin, Germany, 2014.
  21. Pereira, B.; David, L.; Billaud, M.; Almeida, R.. "Post-transcriptional modulation of the LKB1-AMPK-mTOR axis by the RNA-binding protein MEX3A in cancer". Paper presented in 1st ASPIC International Congress, Lisboa, Portugal, 2014.
  22. Pereira, B.; Sousa, S.; Barros, R.; Carreto, L.; Oliveira, P.; Oliveira, C.; Chartier, N.T.; et al. "Modulation of CDX2 expression by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness". Paper presented in European Human Genetics Conference, Paris, France, 2013.
  23. Pereira, B.; Sousa, S.; Barros, R.; Carreto, L.; Oliveira, P.; Oliveira, C.; Chartier, N.T.; et al. "CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness". Paper presented in COST Action CM1106 - Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells, Porto, Portugal, 2013.
  24. Pereira, B.; Sousa, S.; Barros, R.; Carreto, L.; Oliveira, P.; Oliveira, C.; Chartier, N.T.; et al. "CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness". Paper presented in One Day Symposium sponsored by EACR - Darwinian evolution and clonal heterogeneity in human cancer: biological and clinical implications, Porto, Portugal, 2012.
  25. Pereira, B.; Sousa, S.; Carreto, L.; Barros, R.; Oliveira, C.; Freund, J-N.; Billaud, M.; Almeida, R.. "Post-transcriptional regulation of CDX2 expression by MEX3A". Paper presented in EMBO Conference Series on Protein Synthesis and Translational Control, Heidelberg, Germany, 2011.
  26. Pereira, B.; Sousa, S.; Carreto, L.; David, L.; Almeida, R.. "Post-transcriptional regulation of CDX2 expression by MEX3A". Paper presented in 2nd i3S Annual Meeting, Póvoa de Varzim, Portugal, 2011.
  27. Pereira, B.; David, L.; Almeida, R.. "Regulation of CDX2 expression by the microenvironment in the gastric context". Paper presented in XIX Porto Cancer Meeting, Porto, Portugal, 2011.
  28. Barros, R.; Pereira, B.; Camilo, V.; Sousa, S.; David, L.; Almeida, R.. "Intestinal metaplasia: a pre-neoplastic gastric lesion with cellular reprogramming". Paper presented in Cell Symposia: Stem Cell Programming and Reprogramming, Lisboa, Portugal, 2011.
  29. Pereira, B.; David, L.; Almeida, R.. "Regulation of CDX2 expression by the microenvironment in the gastric context". Paper presented in XXI European Association for Cancer Research conference (EACR 21), Oslo, Norway, 2010.
  30. Pereira, B.; David, L.; Almeida, R.. "Regulation of CDX2 expression by the microenvironment in the gastric context". Paper presented in 1st i3S Annual Meeting, Póvoa de Varzim, Portugal, 2010.
  31. Camilo, V.; Barros, R.; Pereira, B.; Magalhães, A.; Reis, C.; Freund, J-N.; David, L.; Almeida, R.. "BMP and Helicobacter pylori downregulate SOX2 expression in gastric cell lines". Paper presented in XXII International Workshop of the European Helicobacter Study Group, Porto, Portugal, 2009.
  32. Pereira, B.; Oliveira, C.; David, L.; Almeida, R.. "CDX2 promoter methylation is not associated with mRNA expression". Paper presented in XXII International Workshop of the European Helicobacter Study Group, Porto, Portugal, 2009.
  33. Barros, R.; Camilo, V.; Pereira, B.; David, L.; Almeida, R.. "CDX2 regulation in intestinal metaplasia of the stomach". Paper presented in Barrett`s Metaplasia Biochemical Society Focused Meeting, Bath, United Kingdom, 2009.
  34. Barros, R.; Pereira, B.; Azevedo, M.; Duluc, I.; Mendes, N.; Paulo, P.; Santos-Silva, F.; et al. "CDX2 expression is regulated by BMP/SMAD4 pathway in human gastric carcinoma cell lines". Paper presented in Digestive Disease Week, San Diego, USA, 2008.
Journal article
  1. Mesquita, Patricia; Coelho, Alexandre; Ribeiro, Ana Sofia; Póvoas, Luís FC; de Oliveira, Catarina V.; Leça, Nelson; Silva, Sara; et al. "The RNA-binding protein YTHDF3 affects gastric cancer cell migration by regulating ezrin". Gastric Cancer (2025):
    Submitted
  2. Vilarinho, Tomás; Pádua, Diana; Pereira, Bruno; Mesquita, Patrícia; Almeida, Raquel. "MISP is overexpressed in intestinal metaplasia and gastric cancer". Current Oncology 31 5 (2024): 2769-2779. http://dx.doi.org/10.3390/curroncol31050210.
    Published • 10.3390/curroncol31050210
  3. Alves-Vale, Catarina; Capela, Ana Maria; Tavares-Marcos, Carlota; Domingues-Silva, Beatriz; Pereira, B.; Santos, Francisco; Gomes, Carla Pereira; et al. "Expression of NORAD correlates with breast cancer aggressiveness and protects breast cancer cells from chemotherapy". Molecular Therapy - Nucleic Acids 33 (2023): 910-924. http://dx.doi.org/10.1016/j.omtn.2023.08.019.
    Published • 10.1016/j.omtn.2023.08.019
  4. Pimenta, J.; Ribeiro, R.; Almeida, R.; Costa, P. F.; da Silva, M. A.; Pereira, B.. "Organ-on-chip approaches for intestinal 3D in vitro modeling". Cellular and Molecular Gastroenterology and Hepatology 13 2 (2022): 351-367. http://dx.doi.org/10.1016/j.jcmgh.2021.08.015.
    Open access • Published • 10.1016/j.jcmgh.2021.08.015
  5. Pereira, B.; Amaral, A. L.; Dias, A.; Mendes, N.; Muncan, V.; Silva, A. R.; Thibert, C.; et al. "MEX3A regulates Lgr5+ stem cell maintenance in the developing intestinal epithelium". EMBO Reports 21 4 (2020): e48938. www.embopress.org/doi/full/10.15252/embr.201948938.
    Open access • Published • 10.15252/embr.201948938
  6. Mesquita, P.; Freire, A.F.; Lopes, N.; Gomes, R.; Azevedo, D.; Barros, R.; Pereira, B.; et al. "Expression and clinical relevance of SOX9 in gastric cancer". Disease Markers 2019 8267021 (2019): www.hindawi.com/journals/dm/2019/8267021/.
    Open access • Published • 10.1155/2019/8267021
  7. Pereira, B.; Billaud, M.; Almeida, R.. "RNA-binding proteins in cancer: old players and new actors". Trends in Cancer 3 7 (2017): 506-528. www.cell.com/trends/cancer/fulltext/S2405-8033(17)30089-4.
    Published • 10.1016/j.trecan.2017.05.003
  8. Tsai, M-H.; Lin, X.; Shumilov, A.; Bernhardt, K.; Feederle, R.; Poirey, R.; Kopp-Schneider, A.; et al. "The biological properties of different Epstein-Barr virus strains explain their association with various types of cancers". Oncotarget 8 6 (2017): 10238-10254. www.oncotarget.com/article/14380/text/.
    Open access • Published • 10.18632/oncotarget.14380
  9. Sadio, A.; Gustafsson, J.K.; Pereira, B.; Gomes, C.P.; Hansson, G.C.; David, L.; Pêgo, A.P.; Almeida, R.. "Modified-chitosan/siRNA nanoparticles downregulate cellular CDX2 expression and cross the gastric mucus barrier". PLoS ONE 9 6 (2014): e99449. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099449.
    Open access • Published • 10.1371/journal.pone.0099449
  10. Pereira, B.; Le Borgne, M.; Chartier, N.T.; Billaud, M.; Almeida, R.. "MEX-3 proteins: recent insights on novel post-transcriptional regulators". Trends in Biochemical Sciences 38 10 (2013): 477-479. www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(13)00135-7.
    Published • 10.1016/j.tibs.2013.08.004
  11. Pereira, B.; Videira, A.; Duarte, M.. "Novel insights into the role of Neurospora crassa NDUFAF2, an evolutionarily conserved mitochondrial complex I assembly factor". Molecular and Cellular Biology 33 13 (2013): 2623-2634. https://mcb.asm.org/content/33/13/2623.long.
    Open access • Published • 10.1128/mcb.01476-12
  12. Pereira, B.; Sousa, S.; Barros, R.; Carreto, L.; Oliveira, P.; Oliveira, C.; Chartier, N.T.; et al. "CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness". Nucleic Acids Research 41 7 (2013): 3986-3999. https://academic.oup.com/nar/article/41/7/3986/1070339.
    Open access • Published • 10.1093/nar/gkt087
  13. Barros, R.; Camilo, V.; Pereira, B.; Freund, J-N.; David, L.; Almeida, R.. "Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation". Biochemical Society Transactions 38 2 (2010): 358-363. https://portlandpress.com/biochemsoctrans/article-abstract/38/2/358/67030/Pathophysiology-of-intestinal-metaplasia-of-the?redirectedFrom=fulltext.
    Published • 10.1042/bst0380358
  14. Pereira, B.; Oliveira, C.; David, L.; Almeida, R.. "CDX2 promoter methylation is not associated with mRNA expression". International Journal of Cancer 125 7 (2009): 1739-1742. https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.24544.
    Open access • Published • 10.1002/ijc.24544
  15. Barros, R; Pereira, B.; Duluc, I; Azevedo, M; Mendes, N; Camilo, V; Jacobs, RJ; et al. "Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines". The Journal of Pathology 215 4 (2008): 411-420. https://onlinelibrary.wiley.com/doi/full/10.1002/path.2369.
    Open access • Published • 10.1002/path.2369
Preprint
  1. Silva, Ana R.; Coelho, Alexandre; Machado, Vanessa; Russel, Morgana; Mexieiro, Dalila; Amaral, Ana L.; Cavadas, Bruno; et al. "Intestinal stem cell marker MEX3A regulates PPARgamma expression with functional impact in colorectal carcinogenesis". 2025. https://doi.org/10.1101/2025.01.13.632758.
    10.1101/2025.01.13.632758
Thesis / Dissertation
  1. Bruno Miguel Correia Pereira. "Regulation of CDX2 and intestinal differentiation in homeostasis and carcinogenesis: emphasis on the role of MEX3A". PhD, Faculty of Medicine of the University of Porto, Portugal, 2013. https://repositorio-aberto.up.pt/handle/10216/82541.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024 Intestinal stem cell marker MEX3A acts as a PPARgamma direct regulator with functional impact in colorectal carcinogenesis (International meeting) 30th Porto Cancer Meeting - RNA biology in cancer: fundamentals and clinical relevance
i3S (Porto, Portugal)
2024 Colorectal cancer patient-derived organoids: promising tools for cancer research and personalised medicine (International meeting; Invited talk) 2nd 3R Day - Models in Biomedical Research
i3S (Porto, Portugal)
2024 Patient-derived organoids: promising tools for cancer research and personalised medicine (Invited talk) Encontro Ciência 2024
Fundação para a Ciência e a Tecnologia (Porto, Portugal)
2023 Intestinal stem cell marker MEX3A acts as a PPARg direct regulator with functional impact in colorectal carcinogenesis (International meeting) EACR conference on Stem Cell Biology, Cancer Plasticity and Therapeutic Potential
European Association for Cancer Research (EACR) (Online)
2022 MEX3A regulates Lgr5+ stem cell maintenance in the developing intestinal epithelium (Crioestaminal & SPCE-TC Award talk) Ageing With]Out[ Borders Conference
(Faro, Portugal)
2020 A gut feeling: new pathways regulating intestinal stem cell identity in development and disease (Invited talk) iBiMED/DCM Seminars Autumn series 2020
Institute of Biomedicine (iBiMED), University of Aveiro (Aveiro, Portugal)
2019 New signalling pathways for intestinal stem cell identity in development and disease Interrogations at the Biointerface, 7th Advanced Summer School: Do organoids fill the in vivo / in vitro gap?
Institute of Biomedical Engineering (INEB) (Porto, Portugal)
2019 Mex3a deletion impairs Lgr5 stem cell maintenance in the mouse gut (International meeting) 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
SPCE-TC (Lisboa, Portugal)
2019 Uncovering the role of the intestinal stem cell marker MEX3A in colorectal carcinogenesis (International meeting) 14th Young European Scientist (YES) Meeting
Faculty of Medicine of the University of Porto (Porto, Portugal)
2018 MEX3A regulates Lgr5+ stem cell maintenance in the developing intestinal epithelium 7th i3S Annual Meeting
i3S, University of Porto (Póvoa de Varzim, Portugal)
2017 RNA-binding protein MEX3A role on intestinal stem cell homeostasis and implications for cancer (International meeting) INFRAFRONTIER / IMPC Stakeholder Meeting - Advancing Personalised Medicine with Animal Models
Infrafrontier research infrastructure (Athens, Greece)
2017 RNA-binding protein MEX3A role on intestinal stem cells homeostasis and implications for cancer (International meeting) 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
SPCE-TC (Covilhã, Portugal)
2017 RNA-binding protein MEX3A role on intestinal stem cells homeostasis and metabolic programming: implications for cancer (Invited talk) XVIII APTAP meeting
Portuguese Association of Pathological Anatomy Technicians (APTAP) (Coimbra, Portugal)
2017 Experimental models in oncology: from 3D cell cultures to animal models (Invited talk) FIT research group seminar series, Centre of Biological Engineering (CEB), University of Minho
(Braga, Portugal)
2015 Dissecting the RNA-binding protein MEX3A functions in stemness, metabolism and polarity (International meeting; Invited talk) XXIII Porto Cancer Meeting - Stem Cells and Cancer
IPATIMUP (Porto, Portugal)
2014 At the crossroads of post-transcriptional regulatory networks: the role of the RNA-binding protein MEX3A in gastrointestinal cancer (Invited talk) 4th i3S Annual Meeting
i3S, University of Porto (Póvoa de Varzim, Portugal)
2013 Regulation of CDX2 and intestinal differentiation in homeostasis and carcinogenesis: unveiling the role of the RNA-binding protein MEX3A (International meeting; Invited talk) 10th International Medical Postgraduate Conference
Organisation for PhD Education in Biomedicine and Health Sciences in the European System (ORPHEUS) (Hradec Králové, Czech Republic)
2012 Modulation of CDX2 expression by the RNA-binding protein MEX3A: impact on intestinal-type differentiation and stemness 16th Annual Meeting of the Portuguese Society of Human Genetics
Portuguese Society of Human Genetics (Porto, Portugal)
2012 RNA-binding protein MEX3A: a new player in the establishment of the intestinal proliferation/differentiation axis 2nd ED-FMUP Meeting
Faculty of Medicine of the University of Porto (Porto, Portugal)
2012 Post-transcriptional regulation of CDX2 expression by MEX3A: impact on intestinal differentiation (Invited talk) XXXième congrès du CECED
Club d'Etude des Cellules Epithéliales Digestives (CECED) (Grenoble, France)
2011 Post-transcriptional regulation of CDX2 expression by MEX3A I Encontro de Doutorandos (ED)-FMUP Meeting
Faculty of Medicine of the University of Porto (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2025 - Current PRECISE-RNA - Unveiling MEX3A therapeutic potential in colorectal cancer tumoroids for RNA-based precision medicine (PhD thesis)
Supervisor of Morgana De Vargas Russel
 Doctoral Program in Molecular and Cell Biology (PhD)
Institute of Biomedical Sciences Abel Salazar, University of Porto, Portugal
2023 - Current stemCODE: deciphering the RNA-binding protein code of stem cells in colorectal cancer (PhD thesis)
Supervisor of Alexandre Rodrigues Coelho
 Doctoral Program in Molecular and Cell Biology (PhD)
Institute of Biomedical Sciences Abel Salazar, University of Porto, Portugal
2021 - Current RBPlasticity: RNA-binding proteins role in normal and malignant intestinal stem cell reprogramming (PhD thesis)
Supervisor of Ana Rita Oliveira Silva
 Biomedicine (PhD)
Faculty of Medicine of the University of Porto, Portugal
2022/01 - 2024/07 Hired junior researcher for the diffNET project. Responsible for the establishment and maintenance of a biobank of patient-derived CRC tumoroids
Supervisor of Vanessa Mendes Machado
 Postdoc
i3S, University of Porto, Portugal
2023 - 2024 Discovering new cancer vulnerabilities by deciphering the m6A RNA Code (MSc Thesis)
Co-supervisor of Sara Viana da Silva
 Molecular Medicine and Oncology (Master)
Faculty of Medicine of the University of Porto, Portugal
2021 - 2022 Functional impact of loss of the intestinal stem cell marker MEX3A in chromosomal instability (CIN)+ colorectal cancer tumoroids (MSc thesis)
Supervisor of Morgana De Vargas Russel
 Oncology (Master)
Institute of Biomedical Sciences Abel Salazar, University of Porto, Portugal
2021 - 2022 RNA transcripts in human breast cancer (MSc thesis)
Co-supervisor of Ana Maria Morais Capela
 Molecular Biomedicine (Master)
Department of Medical Sciences, University of Aveiro, Portugal
2021 - 2022 Bioprinting strategies to engineer biomimetic 3D models of skin burn wounds (MSc thesis)
Co-supervisor of Luís Bebiano
 Master in Biomedical Engineering (Master)
School of Engineering, Polytechnic of Porto, Portugal
2021 - 2022 m6A modification in gastric cancer: the function of the YTH family of proteins (MSc thesis)
Co-supervisor of Beatriz Samor de Almeida
 Cell and Molecular Biology (Master)
Faculty of Sciences of the University of Porto, Portugal, Portugal
2020 - 2021 m6ACODE: Deciphering the hidden message in m6A methylation in gastric cancer (MSc thesis)
Co-supervisor of Diana Cristina Silva Ferreira
 Molecular Medicine and Oncology (Master)
Faculty of Medicine of the University of Porto, Portugal
2020 - 2021 Study of RNA-binding protein networks in colorectal cancer cells (MSc thesis)
Supervisor of Alexandre Rodrigues Coelho
 Oncobiology (Master)
Faculty of Medicine and Biomedical Sciences, University of Algarve, Portugal
2020/08/01 - 2020/11/30 Hired junior researcher for the inSTEM project. Received training in the establishment of intestinal organoid cultures and optimized lentiviral-transduction protocols for organoids
Supervisor of Vanessa Mendes Machado
 Postdoc
i3S, University of Porto, Portugal
2018/11/01 - 2020/02/29 Hired junior researcher for the inSTEM project. Received training in the establishment of intestinal organoid cultures
Supervisor of Marta Luísa Sousa Dias Alves da Silva
 Postdoc
i3S, University of Porto, Portugal
2019 - 2020 Uncovering the MEX3A interactome in normal and malignant intestinal stem cells (MSc thesis)
Supervisor of Ana Rita Oliveira Silva
 Molecular Medicine and Oncology (Master)
Faculty of Medicine of the University of Porto, Portugal
2019 - 2020 The epitranscriptome in gastric cancer: the role of m6A mRNA modifications (MSc thesis)
Co-supervisor of Luís Filipe Costa Póvoas
 Cell and Molecular Biology (Master)
Faculty of Sciences of the University of Porto, Portugal
2019 - 2020 Study of intestinal homeostasis by means of organ-on-chip technologies (MSc thesis)
Co-supervisor of Joana Inês Carlos Pimenta
 Bioengineering (Master)
Faculty of Engineering of the University of Porto, Portugal
2018 - 2019 Role of RNA-binding protein MEX3A in intestinal carcinogenesis (MSc thesis)
Supervisor of Dalila de Jesus Lopes Mexieiro
 Molecular Medicine and Oncology (Master)
Faculty of Medicine of the University of Porto, Portugal
2016 - 2017 Characterization of MEX3A RNA-binding protein in mouse stomach (MSc thesis)
Co-supervisor of Alexandre Miguel Barata Dias
 Molecular Genetics and Biomedicine (Master)
NOVA School of Science and Technology, Portugal
2015 - 2015 The role of MEX3A RNA-binding protein in metabolic regulation in gastrointestinal cancer cell lines (Erasmus+ student, University of Portsmouth, UK)
Co-supervisor of Kiram Jawaid
 Erasmus+ Programme (Scientific initiation)
IPATIMUP, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/05/09 - 2024/05/10 30th Porto Cancer Meeting - a renowned international meeting organized since 1990 and now a flagship meeting of i3S. The scientific program of the 30th Porto Cancer Meeting was focused on RNA biology and its implications in cancer and counted with the participation of excellent speakers (Nahum Sonenberg, Michaela Frye, Jørgen Kjems, Kamil Kranc, Anne Willis, Raúl Mendez, Vinod Balachandran, Maria Carmo Fonseca, and others - https://www.i3s.up.pt/event.php?v=301). (2024)
Meeting (President of the Organising Committee)
 i3S, University of Porto, Portugal
2020/11/23 - 2020/11/23 Organoids With]Out[ Borders - discussion forum regarding the use of stem cells and organoids in mimicking development and disease and for regenerative medicine applications, which counted with the participation of internationally recognized experts (Emma Rawlins, Valeria Orlova, Hugo Snippert, Peter Loskill, Hugo Vankelecom, Carmen Aguilar, Margarida Amaral, and others - https://www.i3s.up.pt/event?v=141) (2020)
Symposium (Co-organisor)
 i3S, University of Porto, Portugal
2012/06/21 - 2012/06/21 2nd PhD Forum - Organizing principles: cell and tissue dynamics: from fundamental biology to disease (2012)
Symposium (Member of the Organising Committee)
 IPATIMUP, Portugal
2010/04/22 - 2010/04/23 XIX Porto Cancer Meeting - Differentiation, Regeneration and Cancer (2010)
Meeting (Member of the Organising Committee)
 IPATIMUP, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2016 - Current Outreach scientific activities as i3S Science Ambassador - involved in hosting high-school students in the lab during i3S Open days and in visits to schools to promote scientific literacy on Cell Biology and Oncobiology (https://cienciaetal.i3s.up.pt)
Other
 Scientific dissemination to high-school students
IPATIMUP, Portugal

i3S, University of Porto, Portugal
2023/04/20 - 2023/04/23 III Oporto Biomedical Summit - medical-scientific conference with a target audience of Medical students from all over the world, gathering up to five hundred participants each year (invited speaker)
Conference
 III Oporto Biomedical Summit
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/11/23 - 2022/11/23 Conference series "Brainload: Power Up Your Knowledge - 5th edition" to discuss new strategies in Oncobiology research, namely the applicability of 3D culture models (invited speaker)
Conference
 Brainload: Power Up Your Knowledge - 5th edition
Universidade de Aveiro, Portugal
2022/09/15 - 2022/09/18 17th YES Meeting (Young European Scientist Meeting) - international conference in the biomedical field organized by students from the Faculty of Medicine, University of Porto (invited chair - Biotechnology session
Conference
 17th YES Meeting
Universidade do Porto Faculdade de Medicina, Portugal
2021/05/17 - 2021/05/21 Conference series "The Limits of Engineering" to discuss limitations of engineering applications considering the speed of scientific and technological development over the last century (invited speaker)
Conference
 Limits in Medicine - Genetic Engineering: Challenges and Ethics
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/04 - 2020/10 Volunteer to the national COVID-19 taskforce. Team leader responsibilities for RT-qPCR testing of SARS-CoV-2 and molecular diagnostics of about 7500 clinical samples from the National Healthcare System. Volunteer in the i3S COVID-19 Diagnostic Centre
i3S, University of Porto, Portugal
2017/09/25 - 2017/09/27 CRCL Cancer Symposium focused on the characterization of cancer cell plasticity and tumour heterogeneity to discuss ongoing work with international collaborators (participant)
Symposium
 3rd International Cancer Symposium of the Cancer Research Center of Lyon
Cancer Research Centre of Lyon (CRCL), France

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2025/03/20 Overcoming multidrug resistance in cancer: evaluating antitumor and collateral sensitivity activity of compounds (PhD thesis)
Thesis Member
 Mélanie Barbosa (PhD)
Faculty of Pharmacy of the University of Porto, Portugal
2024/12/05 On the understanding of mRNA alternative polyadenylation in cancers triggered by tobacco-smoking (MSc thesis)
(Thesis) Main arguer
 Gonçalo Fernandes (Master)
Faculty of Sciences of the University of Porto, Portugal
2023/12/13 Long non-coding RNA NORAD: a potential target for a promising human breast cancer therapy (MSc thesis)
(Thesis) Main arguer
 Carlota Tavares Marcos (Master)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2023/05/15 Influence of ECM dynamics on gastric cancer stem-like properties (PhD thesis)
Thesis Member
 Ana Margarida Oliveira Moreira (PhD)
Institute of Biomedical Sciences Abel Salazar, University of Porto, Portugal
2022 Establishment of glycoengineered cellular models to evaluate the capacity of monosaccharide analogues in blocking the biosynthesis of cancer-associated glycans (MSc thesis)
(Thesis) Main arguer
 Emanuel Sousa Senra (Master)
School of Sciences, University of Minho, Portugal
2021/12/14 A tissue engineering approach to fabricate a stomach-on-a-chip: a biodevice to decode the role of CD44v6 in gastric cancer (PhD thesis)
Thesis Member
 Daniel André Gonçalves Ferreira (PhD)
Institute of Biomedical Sciences Abel Salazar, University of Porto, Portugal
2019/11/04 The role of aberrant glycosylation of CD44 in gastrointestinal carcinoma and its application for cancer biomarker purposes (MSc thesis)
(Thesis) Main arguer
 Álvaro Martinho de Sousa Martins (Master)
School of Sciences, University of Minho, Portugal
2019/03/25 Influence of KRAS activation in the colorectal cancer immunosurveillance escape (MSc thesis)
(Thesis) Main arguer
 Ana Luísa Marinho da Cunha Machado (Master)
School of Health, Polytechnic Institute of Porto, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2013 - Current Peer-reviewer in several international indexed Q1 journals, including Cell Reports, Cancer Letters, EBioMedicine, International Journal of Cancer, Clinical Epigenetics, and Cancers.

Association member

Society Organization name Role
2021 - Current American Gastroenterological Association (AGA) International Affiliate member (1534656)
2020 - Current National Association of Science and Technology Researchers (ANICT) - President 2023/2026 President (2023/2026); Board member (2021/2022); Member (2020)
2018 - Current International Society for Stem Cell Research (ISSCR) Member (ISSCR ID 60094)
2018 - Current Portuguese Society of Stem Cells and Cellular Therapies (SPCE-TC) Member (SPCE-TC 294)
2013 - Current Portuguese Association for Cancer Research (ASPIC) Member (ASPIC 79)
2012 - Current Portuguese Society of Human Genetics (SPGH) Member (SPGH 527)
2012 - Current European Association for Cancer Research (EACR) Member (EACR17330)

Committee member

Activity description
Role 		Institution / Organization
2024/10/01 - Current External Advisory Board member of the Twinning project MPS NOVA Hub (grant No 101159729) to establish a European Hub of Excellence in microphysiological (MPS) systems.
Member
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Universidade Nova de Lisboa Medical School, Portugal
2016 - Current Animal Welfare and Ethics Review Body (ORBEA - Orgão de Bem-Estar e Ética Animal) - member of the Project Reviewer group.
Member
 i3S, University of Porto, Portugal
2019 - 2024 i3S PhD Committee member (Ana Rita Matos, MSc)
Member
 i3S, University of Porto, Portugal
2015 - 2016 IPATIMUP Postdoctoral researchers representative - elected to speak on behalf of IPATIMUP`s postdoctoral community on science policy issues, career development, and working conditions on the i3S Executive Council
Coordinator
 IPATIMUP, Portugal

Conference scientific committee

Conference name Conference host
2024/05/09 - 2024/05/10 30th Porto Cancer Meeting - RNA biology in cancer: fundamentals and clinical relevance i3S, University of Porto, Portugal
2020/11/23 - 2020/11/23 Organoids With]Out[ Borders i3S, University of Porto, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023 - Current Module "3D cell culture systems - stem cells and organoids". Postgraduate course in "Cell culture techniques: from basic cell biology to bioengineering" Cell culture techniques: from basic cell biology to bioengineering (Pós-Graduação) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - Current Laboratory practice "Experimental Models in Cancer Research". Integrated MSc in Medicine Integrated Master in Medicine (Mestrado integrado) Faculty of Medicine of the University of Porto, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2024 - Current Invited evaluator for the Asthma + Lung UK (A+LUK) Research project grants
Evaluator
 Asthma + Lung UK, United Kingdom
2022 - Current Invited evaluator for the Marie Sklodowska-Curie COFUND UNA4CAREER postdoctoral fellowships programme
Evaluator
 Universidad Complutense de Madrid, Spain European Commission Marie Sklodowska-Curie Actions
2022 - Current Evaluator of FCT PhD student fellowships (exceptional grants to mitigate COVID-19 impacts over research activities)
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2021 - Current Invited evaluator for the Worldwide Cancer Research project grants
Evaluator
 Worldwide Cancer Research, United Kingdom Worldwide Cancer Research
2020 - Current Internal reviewer in the i3S Cancer integrative program for FCT projects and individual contract (CEEC) proposals
Evaluator
 i3S, University of Porto, Portugal Fundação para a Ciência e a Tecnologia

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2022/02/18 Merck Biopharma Speed Grant award - press release in Notícias UP Notícias Universidade do Porto
2020/05/25 Publication in EMBO Reports - press release in ASPIC news ASPIC
2020/04/07 Cover of EMBO Reports April 2020 issue - press release in Notícias UP Notícias Universidade do Porto
2017/12/14 Editorial "Exploring RNA-Protein Interactions" Biocompare
2014/12/30 Promising researcher 2015 (Revelação na Ciência) - nominated by Professor Sobrinho Simões (director of IPATIMUP) Jornal de Notícias
2013/11/27 10th International Medical Postgraduate Conference award - press release in ASPIC news ASPIC
2013/09/27 Publication in Trends in Biochemical Sciences - ASPIC news ASPIC

Interview (tv / radio show)

Program Topic
2015 - 2015 TV program "Jornal 2" from channel RTP2 Stem cells in development and disease - on the occasion of the XXIII Porto Cancer Meeting - Stem Cells and Cancer

Journal scientific committee

Journal title (ISSN) Publisher
2022/04 - Current Frontiers in Cell and Developmental Biology - Stem Cell Research (Review Editor) Frontiers
2021 - Current Journal of Visualized Experiments Methods Collection - Guts out: stem cell-derived 3D approaches to study intestinal homeostasis and disease ex vivo (Guest Editor)) JoVE

Other jury / evaluation

Activity description Institution / Organization
2021 - 2021 Tender selection jury member for a Post-doctoral contract (Cancer Research on Therapy Resistance: From Basic Mechanisms to Novel Targets - ref. NORTE-01-0145-FEDER-000051, NORTE project grant) i3S, University of Porto, Portugal
2021 - 2021 Tender selection jury President for a Post-doctoral contract (diffNET: Restoring differentiation in cancer cells by manipulating RNA-binding protein networks - ref. PTDC/BIA-CEL/0456/2021, FCT project grant) i3S, University of Porto, Portugal
2018 - 2020 Tender selection jury President for a Post-doctoral contract (inSTEM: a novel post-transcriptional regulatory network controlling intestinal stem cells fate - ref. POCI-01-0145-FEDER-031538, FCT project grant) i3S, University of Porto, Portugal
2018 - 2018 Tender selection jury member for a Post-doctoral contract (ReProgram: Reconstructing the program of cancer stem cells - ref. POCI-01-0145-FEDER-029017, FCT project grant) i3S, University of Porto, Portugal
Distinctions

Award

2022 Crioestaminal & SPCE-TC Regenerative Medicine Research award (1.0k)
Portuguese Society of Stem Cells and Cellular Therapies (SPCE-TC), Portugal
2017 Young investigator Travel grant (INFRAFRONTIER Stakeholder Meeting, Athens, Greece) - 1.2k EUR
Infrafrontier Research Infrastructure, Germany
2014 EMBO Short Term fellowship, ASTF 280-2013 (IAB, Grenoble, France) - 5.25k EUR
European Molecular Biology Laboratory, Germany
2014 Meeting Bursary (EACR conference Goodbye Flat Biology: 3D models and the tumour microenvironment, Berlin, Germany) - 0.35k EUR
European Association for Cancer Research (EACR), United Kingdom
2013 ESHG National Fellowship (European Human Genetics conference 2013, Paris, France) - 0.8k EUR
European Society of Human Genetics, Austria
2013 Best oral communication and recognized as author of outstanding research (10th International Medical Postgraduate Conference, Hradec Králové, Czech Republic) - 1.5k EUR
Organisation for PhD Education in Biomedicine and Health Sciences in the European System, Croatia
2012 Best oral communication in Basic Research (16th annual meeting of the Portuguese Society of Human Genetics, Porto, Portugal)
Portuguese Society of Human Genetics (SPGH), Portugal
2012 Best oral communication (2nd ED-FMUP meeting, Porto, Portugal)
Faculty of Medicine of the University of Porto, Portugal
2011 EMBL Corporate Partnership registration fee fellowship (Protein Synthesis and Translational Control conference, Heidelberg, Germany) - 0.7k EUR
European Molecular Biology Laboratory (EMBL), Germany

Other distinction

2022 4.ª Edição Prémio FAZ Ciência - Award nominee (top 3 projects)
Fundação AstraZeneca, Portugal
2020 i3S Event of the Year (Organoids With]Out[ Borders symposium, Porto, Portugal)
i3S, University of Porto, Portugal
2015 Promising researcher 2015
Nominated by Professor Sobrinho Simões (director of IPATIMUP), Portugal
2013 National nominee to represent the SPGH at the European Human Genetics Conference (Paris, France)
Portuguese Society of Human Genetics (SPGH), Portugal
2012 Selected to represent the Faculty of Medicine (10th International Medical Postgraduate Conference, Hradec Králové, Czech Republic)
Faculty of Medicine of the University of Porto, Portugal