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Sofia Sousa graduated in Biochemistry by the University of Minho (2019), with a final grade of 17 out of 20, and holds a master`s degree in Pharmaceutical Chemistry by the University of Porto - Faculty of Pharmacy (2021), with a final grade of 17 out of 20. Sofia has a multidisciplinary profile, with experience in molecular docking, molecular biology and organic synthesis. She is currently a PhD student in the doctoral program of Health Sciences in University of Minho, where she was awarded with a PhD grant funded by FCT.
Identification

Personal identification

Full name
Sofia Isabel Martins Sousa
Date of birth
1998/09/12

Citation names

  • Sofia Sousa
  • Sofia M. Sousa
  • Sousa, Sofia M.

Author identifiers

Ciência ID
CB19-FB49-5EB0
ORCID iD
0000-0002-3886-3923

Email addresses

  • sofiaimsousa@gmail.com (Professional)
  • id10589@alunos.uminho.pt (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Exact Sciences - Computer and Information Sciences
  • Medical and Health Sciences
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1)
Education
Degree Classification
2022/09/01 - 2026/09/01
Ongoing
 Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/01/30 - 2023/02/17
Concluded
 Bioinformatics in Health Sciences (Curso de doutoramento (conclusão de unidades curriculares))
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Pass
2022/11/14 - 2022/11/25
Concluded
 Laboratory Animal Science (Curso de doutoramento (conclusão de unidades curriculares))
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Pass
2019 - 2021
Concluded
 Pharmaceutical Chemistry (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"Inhibitors of CHI3L1 for the treatment of pancreatic adenocarcinoma: virtual screening and preliminary studies on inhibition of cell growth" (THESIS/DISSERTATION)
 17
2016 - 2019
Concluded
 Biochemistry (Licenciatura)
Universidade do Minho, Portugal
"Fluorescent benzo[a]phenoxazine probes for biological applications" (THESIS/DISSERTATION)
 17
2010 - 2015
Concluded
 Cambridge English Level 1 Certificate in ESOL International (First) (Outros)
Instituto Britânico de Guimarães, Portugal
 Grade C
Affiliation

Science

Category
Host institution 		Employer
2022/09/01 - Current Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
(...)
2020/09 - 2021/12 Research Trainee (Research) Universidade do Porto Faculdade de Farmácia, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
(...)
2019/03 - 2019/07 Research Trainee (Research) Universidade do Minho, Portugal
Universidade do Minho, Portugal
Outputs

Publications

Conference poster
  1. Sousa, Sofia M.; Proença, Fernanda; Costa, Marta; Sousa, Sérgio F.. "KDM4C epigenetic therapy for triple-negative breast cancer". Paper presented in Encontro Ciência 2024 - Science and Technology Summit, 2024.
  2. Sousa, Sofia M.; Proença, Fernanda; Costa, Marta; Sousa, Sérgio F.. "Design of new epigenetic inhibitors for the treatment of triple negative breast cancer". Paper presented in 6th Meeting of Medicinal Biotechnology, 2024.
  3. Sousa, Sofia M.; Proença, Fernanda; Costa, Marta; Sousa, Sérgio F.. "Therapeutic epigenetic KDM4C remodeling for the treatment of triple negative breast cancer". Paper presented in 30th Porto Cancer Meeting, 2024.
  4. Sousa, Sofia M.; Proença, Fernanda; Costa, Marta; Sousa, Sérgio F.. "Virtual screening of potential KDM4C inhibitors for the treatment of triple negative breast cancer". Paper presented in XXVII Encontro Luso-Galego de Química, 2023.
  5. Sousa, Sofia M.; Proença, Fernanda; Costa, Marta; Sousa, Sérgio F.. Corresponding author: Sousa, Sofia M.. "Development of virtual screening protocols for the design of novel KDM4C inhibitors for the treatment of triple negative breast cancer". Paper presented in III ASPIC-ASEICA International Meeting – Cancer Immunology, Tumor Microenvironment and Metastasis, 2023.
  6. Sousa, Sofia M.; Proença, Fernanda; Costa, Marta; Sousa, Sérgio F.. "Otimização de protocolos especializados de virtual screening para o design de novas moléculas inibidoras da KDM4C para o tratamento do cancro da mama triplo negativo". Paper presented in 5º Encontro Nacional de Jovens Investigadores em Oncologia, 2023.
  7. Helena Branco; Sofia Sousa; Amir Avan; Andreia Palmeira; Elisa Giovannetti; Maria Helena Vasconcelos ; Cristina P.R. Xavier. "Darifenacin as novel chemosensitizer in pancreatic cancer". Paper presented in The 2023 Annual Congress of the European Association for Cancer Research (EARC 2023), 2023.
  8. Cristina P.R. Xavier; Helena Branco; Sofia M. Sousa; Amir Avan; Andreia Palmeira; Elisa Giovannetti; M. Helena Vasconcelos. Corresponding author: Cristina P.R. Xavier. "Chitinase 3-like-1 identified in large extracellular vesicles from human macrophages: a promising therapeutic drug target for pancreatic cancer (Best Poster Award in the session I of EVs in Cancer)". Paper presented in 2nd meeting of the Portuguese Network on extracellular vesicles (PNEV), 2023.
  9. Cristina P.R. Xavier; Sofia Sousa; Helena Branco; Lucio Lara Santos; Andreia Palmeia; Maria Helena Vasconcelos. "Efeito sensibilizador da darifenacina a agentes citotóxicos no cancro pancreático: estudo in silico e em linhas celulares". Paper presented in 4º Encontro Nacional Jovens Investigadores em Oncologia, 2022.
  10. Cristina P.R. Xavier; Andreia Palmeira; Sofia Sousa; Helena Branco; Dylan Ferreira; Lúcio L. Santos; Maria J. Oliveira; M. Helena Vasconcelos. "Targeting Chitinase-like-1 (CHI3L1) as a therapeutic target for pancreatic cancer". Paper presented in II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer, 2021.
  11. Cristina P.R. Xavier; S. Sousa; H. Branco; Lúcio L. Santos; A. Palmeira; M. Helena Vasconcelos. "Targeting chitinase 3-like 1 in pancreatic cancer: in silico identification of inhibitors from a DrugBank database and confirmation of growth inhibition effect in cell lines". Paper presented in XXVII Encontro nacional da Sociedade Portuguesa de Química, 2021.
  12. Cristina P.R. Xavier; A. Palmeira; S. Sousa; Inês Castro; Hugo R. Caires; Dylan Ferreira; Bruno Cavadas; et al. "Identification of Chitinase 3-like 1 as a therapeutic target for pancreatic cancer in large extracellular vesicles from human macrophages". Paper presented in SNEV 2021 (Student Network on Extracellular Vesicles), 2021.
  13. Sousa, S.I.; Xavier, C.P.R.; Vasconcelos, M.H.; Palmeira, A. "Virtual screening of known drugs in search of inhibitors of CHI3L1 for the treatment of pancreatic cancer". Paper presented in 14th Meeting of Young Researchers of University of Porto, 2021.
Journal article
  1. Costa Cerqueira, Mónica; Silva, Ana; Sofia M. Sousa; Pinto-Ribeiro, Filipa; Baltazar, Fátima; Afonso, Julieta; Freitas Costa, Marta. Corresponding author: Freitas Costa, Marta. "Chromene-based compounds as drug candidates for renal and bladder cancer therapy – A systematic review". Bioorganic Chemistry (2024): 107865. http://dx.doi.org/10.1016/j.bioorg.2024.107865.
    Open access • Published • 10.1016/j.bioorg.2024.107865
  2. Sofia M. Sousa; Branco, Helena; Avan, Amir; Palmeira, Andreia; Morelli, Luca; Santos, Lúcio L.; Giovannetti, Elisa; Vasconcelos, M. Helena; Xavier, Cristina P. R.. "Darifenacin: a promising chitinase 3-like 1 inhibitor to tackle drug resistance in pancreatic ductal adenocarcinoma". Cancer Chemotherapy and Pharmacology (2024): http://dx.doi.org/10.1007/s00280-024-04712-1.
    Open access • Published • 10.1007/s00280-024-04712-1
  3. Sofia M. Sousa; Xavier, Cristina Pinto Ribeiro; Vasconcelos, Maria Helena; Palmeira, Andreia. "Repurposing some of the Well-known Non-steroid Anti-inflammatoryDrugs (NSAIDs) for Cancer Treatment". Current Topics in Medicinal Chemistry 23 13 (2023): 1171-1195.
    Published • 10.2174/1568026623666230130150029
Thesis / Dissertation
  1. "Inhibitors of CHI3L1 for the treatment of pancreatic adenocarcinoma: virtual screening and preliminary studies on inhibition of cell growth". Master, Universidade do Porto Faculdade de Farmácia, 2021. https://sigarra.up.pt/ffup/pt/pub_geral.pub_view?pi_pub_base_id=504601.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/12/18 Design of novel KDM4C inhibitors for the treatment of triple negative breast cancer 3D-BioInfo-PT
(Coimbra, Portugal)
2021/12/03 Chitinase 3-like-1 (CHI3L1) as a potential therapeutic target for pancreatic cancer 5th Congress of SDIR: Translational Potential of Cancer Research in Serbia (virtual event)
2021/09/13 Chitinase 3-like-1 found in the cargo of large extracellular vesicles released by human macrophages: potential therapeutic target for pancreatic cancer 1st Meeting of the Portuguese Network on Extracellular Vesicles
i3S - Instituto de Investigação e Inovação em Saúde da Universidade do Porto (Porto, Portugal)
2021/06/07 Identification of Chitinase 3-like 1 (CHI3L1) as a therapeutic target for pancreatic cancer present in large extracellular vesicles from human macrophages III International AICC Exosome meeting (virtual meeting)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/12/19 - 2022/12/21 Intermediate Workshops (Lecture + Practical): Machine Learning; Atomistic/Coarse-Grain MD; Comparative Modeling/AlphaFold; Compound Databases and Screening. 3D-BioInfo-PT meeting.
Workshop
 3D-BioInfo-PT
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2022/09/24 - 2022/09/24 4º ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA (ENJIO). Poster presented in the conference about my masters dissertation theme. 4º Encontro Nacional Jovens Investigadores em Oncologia
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2021/12/17 - 2021/12/17 Conferências em Oncobiologia. Organized within the curriculum unit "Oncobiologia" Conferências em Oncobiologia
Universidade do Porto Faculdade de Farmácia, Portugal
2021/12/03 - 2021/12/03 5th Congress of Serbian Association for Cancer Research (SDIR): Translational Potential of Cancer Research in Serbia (virtual event)
Congress
 5th Congress of SDIR: Translational Potential of Cancer Research in Serbia (virtual event)
2021/07/14 - 2021/07/16 Chemistry and Opportunities in a Global Society (online assistance)
Meeting
 XXVII Encontro nacional da Sociedade Portuguesa de Química
Universidade do Minho, Portugal
2021/05/20 - 2021/05/21 Stemness & Metastasis: Advances in Research and Clinical Translation (online event)
Meeting
 27th Porto Cancer Meeting
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/05/24 - 2019/05/24 4th Symposium on Medicinal Chemistry
Symposium
 4th Symposium on Medicinal Chemistry
Universidade do Minho, Portugal
2019/03/11 - 2019/03/15 Participation in workshops: "Culture in vitro: science to industry" by engineer Andreia Afonso; "Using the nematode Caenorhabditis elegans in study of neurodegenerative diseases" by doctor Andreia Castro; "Biochemistry and Medicinal Chemistry: What do they have in common?" by doctor Alice Carvalho; "Cell culture: A good model in biochemical pharmacology" by doctor Olga Coutinho
Meeting
 [ciência] - Concentra o Conhecimento
Universidade do Minho, Portugal
2018/04/10 - 2018/04/11 Participation in the workshop "Analysis of antioxidant activity of plant extracts by flow cytometry"
Congress
 IX Biochemistry Days- From investigation to industry
Universidade do Minho, Portugal
2018/03/23 - 2018/03/26 Participation in workshops: "Medicinal chemistry" by Madalena Pinto and Emília Sousa; " How to make effective presentations" by Norberto Amaral
Meeting
 XI ENEBIOQ - décima primeira edição do Encontro Nacional de Estudantes de Bioquímica
2017/07/08 - 2017/07/08 VII Biochemistry Days - 10 years of course
Congress
 VII Biochemistry Days
Universidade do Minho, Portugal
Distinctions

Award

2022 PhD Studentships
Fundação para a Ciência e a Tecnologia, Portugal