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Nuno C. Santos was born in Lisbon, Portugal, in 1972. He graduated in Biochemistry from the Faculty of Science, University of Lisbon, in 1995, and received his PhD in Theoretical and Experimental Biochemistry in 1999 from the same University, although all the experimental work was conducted at Instituto Superior Técnico (Technical University of Lisbon) and University of California (Santa Barbara). Currently, he is Associate Professor with Habilitation of the Faculty of Medicine, University of Lisbon, and Head of the Biomembranes & Nanomedicine Unit at the Gulbenkian Institute for Molecular Medicine (GIMM), which was created in 2024 upon the merging between Instituto de Medicina Molecular (iMM), where he was previously Group Leader, and Instituto Gulbenkian de Ciência (IGC). Among other distinctions, his research work was awarded with the Gulbenkian Prize for young researchers (2001), Dr. José Luis Champalimaud Prize – Basic Research (2004), Dr. José Luis Champalimaud Prize – Applied Research and Technology (2005) and the ULisboa – Caixa Geral de Depósitos Prize (2017 and 2023). He is (co)author of 191 articles in per-reviewed international journals, which received more than 10800 citations (h index 56 and i10-index 147, publishing since 1996), presenting a Journal Citation Reports impact factor sum of 1052.9 (average 5.6 per article). In addition to these publications, he (co)authored 10 articles in Portuguese scientific journals, 15 book chapters (mostly published outside Portugal, in English), 3 books (editor, published by Wiley, Springer and MDPI) and 2 international patents. Among different National and International research projects, he was the coordinator of a European Union-funded consortium including 10 different research groups from Europe and Brazil. He is member of the Executive Committee of the European Biophysical Societies’ Association (EBSA) since 2019, and the Director of the M2B-PhD Doctoral Program in Medical Biochemistry and Biophysics (involving 5 different institutions) since 2016. He was President of the Portuguese Biophysical Society from 2015 to 2021. He has supervised 16 completed PhDs, 10 as main supervisor and 6 as co-supervisor. (November 2024)
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Identification

Personal identification

Full name
Nuno Fernando Duarte Cordeiro Correia dos Santos

Citation names

  • Santos, Nuno C.
  • Santos, N.C.

Author identifiers

Ciência ID
CD13-5E3A-A3C5
ORCID iD
0000-0002-0580-0475
Google Scholar ID
hmISCFoAAAAJ&hl

Email addresses

  • nsantos@medicina.ulisboa.pt (Professional)
  • nsantos@fm.ul.pt (Professional)

Addresses

  • Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Biochemical Research Methods
  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Virology
  • Engineering and Technology - Nano-technology
  • Engineering and Technology - Medical Engineering - Medical Engineering
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Health Sciences - Infectious Diseases
  • Medical and Health Sciences - Clinical Medicine - Cardiac and Cardiovascular Systems
  • Medical and Health Sciences - Clinical Medicine - Endocrinology and Metabolism
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2010/06/15
Concluded
 Ciências Biomédicas (Título de Agregado)
Universidade de Lisboa Faculdade de Medicina, Portugal
1999/11/16
Concluded
 Bioquímica (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

University of California Santa Barbara Department of Chemical Engineering, United States
1995/07/20
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 16.5
Affiliation

Science

Category
Host institution 		Employer
2024/10/01 - Current Principal Investigator (Research) Gulbenkian Institute for Molecular Medicine, Portugal
Gulbenkian Institute for Molecular Medicine, Portugal
2008/01/01 - 2024/09/30 Principal Investigator (Research) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
1994/09/01 - 1999/02/28 Researcher (Research) Universidade de Lisboa Centro de Química-Física Molecular, Portugal
1997/02/01 - 1997/05/31 Visiting Researcher (Research) University of California at Santa Barbara, United States

Teaching in Higher Education

Category
Host institution 		Employer
2013 - Current Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
2000/03/01 - 2010/06/15 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
1999/03/01 - 2000/02/29 Trainee Assistant (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2021/03/29 - 2024/03/28 Fibrinogen-erythrocyte interaction as a new approach on the early detection of thrombotic events in vascular diseases
PTDC/EMD-TLM/7289/2020
Principal investigator
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/04/01 - 2023/03/31 SAFETY TESTING IN THE LIFE CYCLE OF NANOTECHNOLOGY-ENABLED MEDICAL TECHNOLOGIES FOR HEALTH.
info:eu-repo/grantAgreement/EC/H2020/814607/EU
Researcher
European Commission
Ongoing
2018/10/01 - 2021/09/30 iDNArT - Intelligent DNA nanostructures aimed at brain therapeutics
PTDC/NAN-MAT/30898/2017
Researcher
Ongoing
2018/10/01 - 2021/09/30 When the host cell is not so cosy anymore? A drop off in energy or an increase in toxicity?
PTDC/BIA-CEL/28456/2017
Researcher
Ongoing
2016/05/01 - 2019/10/31 Broad-spectrum antiviral peptides against respiratory viruses
PTDC/BBB-BQB/3494/2014
Principal investigator
Concluded
2016/05/01 - 2019/10/31 Molecular interactions of circulating fibrinogen as a risk factor for cardiovascular and cerebrovascular pathologies
PTDC/BBB-BMD/6307/2014
Researcher
Concluded
2015/02/01 - 2019/01/31 Engineering protease-resistant alpha-beta peptides for broad-spectrum antivirals
info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES/5R01AI114736-04/US
Researcher
2015/02/01 - 2019/01/31 Innovative peptides against cancer and pathogenic bacteria, with advances in science, biopharmaceutical drug development, product market targeting, training , and communication.
info:eu-repo/grantAgreement/EC/H2020/644167/EU
Researcher
Concluded
2012/03/01 - 2015/08/31 AMYLOIDETECTORS: Employing amyloid fibrils as biosensors of the interaction of peptides with phospholipids and/or protein domains.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/117013/PT
Researcher
Concluded
2012/03/01 - 2015/08/31 Molecular characterization of the fibrinogen-eryhthrocyte interaction and its influence on Cardivascular pathologies
info:eu-repo/grantAgreement/FCT/3599-PPCDT/119509/PT
Principal investigator
Concluded
2012/02/01 - 2015/01/31 ADHESION, DIFFERENTIATION AND INVASION: DIFFERENT PROCESSES, COMMON CADHERIN PLAYERS
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBPD2%F757052%F2011/PT
Researcher
Concluded
2011/03/01 - 2014/08/31 Membrane fusion mechanism of Influenza Hemagglutinin: a simulation and biophysical approach.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/114774/PT
Researcher
Concluded
2011/03/01 - 2014/08/31 LIPIDENGUE: The role of hepatic lipid membranes and lipid droplets in Dengue virus encapsidation. A gateway to new therapies.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/112929/PT
Researcher
Concluded
2010/01/31 - 2014 Membrane-active peptides across disciplines and continents: An integrated approach to find new strategies to fight bacteria, dengue virus and neurodegeneration.
info:eu-repo/grantAgreement/EC/FP7/247513/EU
Principal investigator
Concluded
2011/07/15 - 2013/03/31 Cell membrane features in HIV entry and its inhibition
info:eu-repo/grantAgreement/FCT/3599-PPCDT/104787/PT
Principal investigator
Concluded
2009/03/01 - 2013/02/28 Selected peptides as drug candidates directed to pain and neurodegeneration
info:eu-repo/grantAgreement/EC/FP7/230654/EU
Researcher
Concluded
2010/02/01 - 2013/01/31 Inherent antibacterial activity in peptide-based hydrogels for tissue regeneration
info:eu-repo/grantAgreement/FCT/3599-PPCDT/99142/PT
Researcher
2010/01/01 - 2012/12/31 MULTI-TARGET HIV ENTRY INHIBITORS DELIVERY BY CATIONIC LIPOSOMES
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBPD2%F655312%F2009/PT
Researcher
Concluded
2008/02/11 - 2011/06/09 Metal- and magnetic nanoparticles functionalized with biological molecules: towards bio-nanoprobes
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/64484/PT
Researcher
Concluded
2009/06/05 - 2011/06/04 The role of lipid membranes in dengue virus assembly
info:eu-repo/grantAgreement/EC/FP7/237373/EU
Supervisor
2007/12/01 - 2011/05/30 The role of lipid membranes in Dengue virus cell infection
info:eu-repo/grantAgreement/FCT/3599-PPCDT/69937/PT
Researcher
Concluded
2007/01/01 - 2010/03/31 Fibrinogen and signal transduction on Microcirculation – Implications in inflammation and cardiovascular diseases
PTDC/SAU-OSM/73449/2006
Researcher
Concluded
2000/11/01 - 2002/10/31 The interaction of HIV-1 membrane protein gp41 fusion peptide with biomembranes and its inhibition
info:eu-repo/grantAgreement/FCT/POCI/12049/PT
Researcher
Concluded
Outputs

Publications

Book
  1. Santos, N.C.; Carvalho, F.A.. Preface. 2019.
  2. Lopes, C.S.; Carvalho, F.A.; Santos, N.C.. Atomic force microscopy: A tool for imaging, manipulating biomolecules, and quantifying single-molecule interactions in biological systems. 2017.
  3. Castanho, M.; Santos, N.C.. Preface. 2011.
  4. Santos, Nuno C.. Peptide Drug Discovery and Development. Wiley-VCH Verlag GmbH & Co. KGaA. 2011.
    10.1002/9783527636730
Journal article
  1. Marlon H. Cardoso; Cesar de la Fuente-Nunez; Nuno C. Santos; Michael A. Zasloff; Octávio L. Franco. "Influence of antimicrobial peptides on the bacterial membrane curvature and vice versa". Trends in Microbiology (2024): https://doi.org/10.1016/j.tim.2024.04.012.
    10.1016/j.tim.2024.04.012
  2. Liana Costa Pereira Vilas Boas; Danieli Fernanda Buccini; Rhayfa Lorrayne Araújo Berlanda; Bruno de Paula Oliveira Santos; Mariana Rocha Maximiano; Luciano Morais Lião; Sónia Gonçalves; Nuno C. Santos; Octávio Luiz Franco. "Antiviral Activities of Mastoparan-L-Derived Peptides against Human Alphaherpesvirus 1". Viruses (2024): https://doi.org/10.3390/v16060948.
    10.3390/v16060948
  3. Artur J. M. Valente; Nuno C. Santos; Maria João Moreno. "State-of-the-Art Macromolecules in Portugal". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25010620.
    10.3390/ijms25010620
  4. Catarina S. Lopes; Ana Catarina Pronto-Laborinho; Vasco A. Conceição; Teresa Freitas; Gonçalo L. Matias; Marta Gromicho; Nuno C. Santos; Mamede de Carvalho; Filomena A. Carvalho. "Erythrocytes' surface properties and stiffness predict survival and functional decline in ALS patients". BioFactors (2023): https://doi.org/10.1002/biof.2030.
    10.1002/biof.2030
  5. Priscilla L. S. Boon; Ana S. Martins; Xin Ni Lim; Francisco J. Enguita; Nuno C. Santos; Peter J. Bond; Yue Wan; Ivo C. Martins; Roland G. Huber. "Dengue Virus Capsid Protein Facilitates Genome Compaction and Packaging". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24098158.
    10.3390/ijms24098158
  6. Sónia Gonçalves; Nuno C. Santos. "Membrane–Peptide Interactions: From Basics to Current Applications 2.0". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24087202.
    10.3390/ijms24087202
  7. Catarina S. Lopes; Juliana Curty; Filomena A. Carvalho; A. Hernández-Machado; Koji Kinoshita; Nuno C. Santos; Rui D. M. Travasso. "A mathematical model of fibrinogen-mediated erythrocyte–erythrocyte adhesion". Communications Biology (2023): https://doi.org/10.1038/s42003-023-04560-4.
    10.1038/s42003-023-04560-4
  8. Maria Carvalho; Márcia M. Medeiros; Inês Morais; Catarina S. Lopes; Ana Balau; Nuno C. Santos; Filomena A. Carvalho; Ana Paula Arez. "2,3-Diphosphoglycerate and the Protective Effect of Pyruvate Kinase Deficiency against Malaria Infection—Exploring the Role of the Red Blood Cell Membrane". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24021336.
    10.3390/ijms24021336
  9. Ivo C. Martins; Rafaela C. Ricardo; Nuno C. Santos. "Dengue, West Nile, and Zika Viruses: Potential Novel Antiviral Biologics Drugs Currently at Discovery and Preclinical Development Stages". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14112535.
    10.3390/pharmaceutics14112535
  10. Sónia Gonçalves; Ivo C. Martins; Nuno C. Santos. "Nanoparticle-peptide conjugates for bacterial detection and neutralization: Potential applications in diagnostics and therapy". WIREs Nanomedicine and Nanobiotechnology (2022): https://doi.org/10.1002/wnan.1819.
    10.1002/wnan.1819
  11. Maïssa Dardouri; Ana Bettencourt; Victor Martin; Filomena A. Carvalho; Bruno Colaço; Adelina Gama; Madeleine Ramstedt; et al. "Assuring the Biofunctionalization of Silicone Covalently Bonded to Rhamnolipids: Antibiofilm Activity and Biocompatibility". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14091836.
    10.3390/pharmaceutics14091836
  12. Patrícia M. Silva; Inês Vieira da Silva; Maria J. Sarmento; Silva, Í. C.; Filomena A. Carvalho; Graça Soveral; Nuno C. Santos. "Aquaporin-3 and Aquaporin-5 Facilitate Migration and Cell–Cell Adhesion in Pancreatic Cancer by Modulating Cell Biomechanical Properties". Cells (2022): https://www.mdpi.com/2073-4409/11/8/1308.
    10.3390/cells11081308
  13. Liliana S. Alves; André R. A. Marques; Nuno Padrão; Filomena A. Carvalho; José Ramalho; Catarina S. Lopes; Maria I. L. Soares; et al. "Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth muscle cell homeostasis". Journal of Cell Science (2022): https://doi.org/10.1242/jcs.254631.
    10.1242/jcs.254631
  14. Marta C. Marques; Diana Lousa; Patrícia M. Silva; André F. Faustino; Claudio M. Soares; Nuno C. Santos. "The Importance of Lipid Conjugation on Anti-Fusion Peptides against Nipah Virus". Biomedicines (2022): https://www.mdpi.com/2227-9059/10/3/703.
    10.3390/biomedicines10030703
  15. Joana C. Barbosa; Ítala C. Silva; Tânia Caetano; Eva Mösker; Maria Seidel; Joana Lourenço; Roderich D. Süssmuth; et al. "Assessing the potential of the two-peptide lantibiotic lichenicidin as a new generation antimicrobial". World Journal of Microbiology and Biotechnology 38 1 (2022): https://doi.org/10.1007/s11274-021-03196-y.
    10.1007/s11274-021-03196-y
  16. Plácido, A.; do Pais do Amaral, C.; Teixeira, C.; Nogueira, A.; Brango-Vanegas, J.; Alves Barbosa, E.; C. Moreira, D.; et al. "Neuroprotective effects on microglia and insights into the structure–activity relationship of an antioxidant peptide isolated from Pelophylax perezi". Journal of Cellular and Molecular Medicine 26 10 (2022): 2793-2807. http://www.scopus.com/inward/record.url?eid=2-s2.0-85128779284&partnerID=MN8TOARS.
    10.1111/jcmm.17292
  17. Tânia B. Cruz; Filomena A. Carvalho; Paulo N. Matafome; Raquel A. Soares; Nuno C. Santos; Rui D. Travasso; Maria J. Oliveira. "Mice with Type 2 Diabetes Present Significant Alterations in Their Tissue Biomechanical Properties and Histological Features". Biomedicines (2021): https://doi.org/10.3390/biomedicines10010057.
    10.3390/biomedicines10010057
  18. Louis De Falco; Nelly M. Silva; Nuno C. Santos; Roland G. Huber; Ivo C. Martins. "The Pseudo-Circular Genomes of Flaviviruses: Structures, Mechanisms, and Functions of Circularization". Cells (2021): https://doi.org/10.3390/cells10030642.
    10.3390/cells10030642
  19. Marco M. Domingues; Bárbara Gomes; Axel Hollmann; Nuno C. Santos. "25-Hydroxycholesterol Effect on Membrane Structure and Mechanical Properties". International Journal of Molecular Sciences 22 5 (2021): 2574-2574. https://doi.org/10.3390/ijms22052574.
    10.3390/ijms22052574
  20. Marcin Makowski; Mário R. Felício; Isabel C. M. Fensterseifer; Octávio L. Franco; Nuno C. Santos; Sónia Gonçalves. "EcDBS1R4, an Antimicrobial Peptide Effective against Escherichia coli with In Vitro Fusogenic Ability". International Journal of Molecular Sciences 21 23 (2020): 9104-9104. https://doi.org/10.3390/ijms21239104.
    10.3390/ijms21239104
  21. Francisca Lidiane Linhares de Aguiar; Nuno C. Santos; Carolina Sidrim de Paula Cavalcante; David Andreu; Gandhi Radis Baptista; Sónia Gonçalves. "Antibiofilm Activity on Candida albicans and Mechanism of Action on Biomembrane Models of the Antimicrobial Peptide Ctn[15–34]". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21218339.
    10.3390/ijms21218339
  22. Nelly M. Silva; Nuno C. Santos; Ivo C. Martins. "Dengue and Zika Viruses: Epidemiological History, Potential Therapies, and Promising Vaccines". Tropical Medicine and Infectious Disease 5 4 (2020): 150-150. https://doi.org/10.3390/tropicalmed5040150.
    10.3390/tropicalmed5040150
  23. Martins, Ivo C.; Santos, Nuno C.. "Intrinsically disordered protein domains in flavivirus infection". Archives of Biochemistry and Biophysics 683 (2020): 108298. http://dx.doi.org/10.1016/j.abb.2020.108298.
    10.1016/j.abb.2020.108298
  24. André F. Faustino; Glauce M. Barbosa; Micael Silva; Miguel A. R. B. Castanho; Andrea T. Da Poian; Eurico J. Cabrita; Nuno C. Santos; Fabio C. L. Almeida; Ivo C. Martins. "Fast NMR method to probe solvent accessibility and disordered regions in proteins". Scientific Reports 9 1 (2019): https://doi.org/10.1038/s41598-018-37599-z.
    10.1038/s41598-018-37599-z
  25. de Barros, Elizângela; Gonçalves, Regina M.; Cardoso, Marlon H.; Santos, Nuno C.; Franco, Octávio L.; Cândido, Elizabete S.. "Snake Venom Cathelicidins as Natural Antimicrobial Peptides". Frontiers in Pharmacology 10 (2019): http://dx.doi.org/10.3389/fphar.2019.01415.
    10.3389/fphar.2019.01415
  26. Marcin Makowski; Ítala C. Silva; Constança Pais do Amaral; Sónia Gonçalves; Nuno C. Santos. "Advances in Lipid and Metal Nanoparticles for Antimicrobial Peptide Delivery". Pharmaceutics (2019): https://doi.org/10.3390/pharmaceutics11110588.
    10.3390/pharmaceutics11110588
  27. Bárbara Gomes; Giusepinna Sanna; Silvia Madeddu; Axel Hollmann; Nuno C. Santos. "Combining 25-Hydroxycholesterol with an HIV Fusion Inhibitor Peptide: Interaction with Biomembrane Model Systems and Human Blood Cells". ACS Infectious Diseases (2019): https://doi.org/10.1021/acsinfecdis.8b00321.
    10.1021/acsinfecdis.8b00321
  28. Irazazabal, L.N.; Porto, W.F.; Fensterseifer, I.C.M.; Alves, E.S.F.; Matos, C.O.; Menezes, A.C.S.; Felício, M.R.; et al. "Fast and potent bactericidal membrane lytic activity of PaDBS1R1, a novel cationic antimicrobial peptide". Biochimica et Biophysica Acta - Biomembranes 1861 1 (2019): 178-190. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054381490&partnerID=MN8TOARS.
    10.1016/j.bbamem.2018.08.001
  29. Ana Filipa Guedes; Carlos Moreira; José B. Nogueira; Nuno C. Santos; Filomena A. Carvalho. "Fibrinogen–erythrocyte binding and hemorheology measurements in the assessment of essential arterial hypertension patients". Nanoscale (2019): https://doi.org/10.1039/C8NR04398A.
    10.1039/C8NR04398A
  30. Carvalho, P.M.; Felício, M.R.; Santos, N.C.; Gonçalves, S.; Domingues, M.M.. "Application of light scattering techniques to nanoparticle characterization and development". Frontiers in Chemistry 6 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85049202256&partnerID=MN8TOARS.
    10.3389/fchem.2018.00237
  31. Meneguetti, B.T.; Cardoso, M.H.; Ribeiro, C.F.A.; Felício, M.R.; Pinto, I.B.; Santos, N.C.; Carvalho, C.M.E.; Franco, O.L.. "Neuropeptide receptors as potential pharmacological targets for obesity". Pharmacology and Therapeutics (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85057627257&partnerID=MN8TOARS.
    10.1016/j.pharmthera.2018.11.002
  32. Carvalho, F.A.; Guedes, A.F.; Duval, C.; Macrae, F.L.; Swithenbank, L.; Farrell, D.H.; Ariëns, R.A.S.; Santos, N.C.. "The95RGD97sequence on the Aa Chain of fibrinogen is essential for binding to its erythrocyte receptor". International Journal of Nanomedicine 13 (2018): 1985-1992. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045300534&partnerID=MN8TOARS.
    10.2147/IJN.S154523
  33. Figueira, T.N.; Augusto, M.T.; Rybkina, K.; Stelitano, D.; Noval, M.G.; Harder, O.E.; Veiga, A.S.; et al. "Effective in Vivo Targeting of Influenza Virus through a Cell-Penetrating/Fusion Inhibitor Tandem Peptide Anchored to the Plasma Membrane". Bioconjugate Chemistry 29 10 (2018): 3362-3376. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053669384&partnerID=MN8TOARS.
    10.1021/acs.bioconjchem.8b00527
  34. Guedes, A.F.; Carvalho, F.A.; Domingues, M.M.; Macrae, F.L.; McPherson, H.R.; Sabban, A.; Martins, I.C.; et al. "Impact of ¿'¿' fibrinogen interaction with red blood cells on fibrin clots". Nanomedicine 13 19 (2018): 2491-2505. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055917620&partnerID=MN8TOARS.
    10.2217/nnm-2018-0136
  35. Jeremias, H.F.; Lousa, D.; Hollmann, A.; Coelho, A.C.; Baltazar, C.S.; Seixas, J.D.; Marques, A.R.; et al. "Study of the interactions of bovine serum albumin with a molybdenum(II) carbonyl complex by spectroscopic and molecular simulation methods". PLoS ONE 13 9 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85053913626&partnerID=MN8TOARS.
    10.1371/journal.pone.0204624
  36. Gomes, B.; Augusto, M.T.; Felício, M.R.; Hollmann, A.; Franco, O.L.; Gonçalves, S.; Santos, N.C.. "Designing improved active peptides for therapeutic approaches against infectious diseases". Biotechnology Advances 36 2 (2018): 415-429. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042940089&partnerID=MN8TOARS.
    10.1016/j.biotechadv.2018.01.004
  37. Martins, A.S.; Martins, I.C.; Santos, N.C.. "Methods for lipid droplet biophysical characterization in flaviviridae infections". Frontiers in Microbiology 9 AUG (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85051847327&partnerID=MN8TOARS.
    10.3389/fmicb.2018.01951
  38. Ribeiro, A.S.; Nobre, A.R.; Mendes, N.; Almeida, J.; Vieira, A.F.; Sousa, B.; Carvalho, F.A.; et al. "SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells". Cell communication and signaling : CCS 16 1 (2018): 75-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056432555&partnerID=MN8TOARS.
    10.1186/s12964-018-0286-2
  39. Bravo-Ferrada, B.M.; Gonçalves, S.; Semorile, L.; Santos, N.C.; Brizuela, N.S.; Elizabeth Tymczyszyn, E.; Hollmann, A.. "Cell surface damage and morphological changes in Oenococcus oeni after freeze-drying and incubation in synthetic wine". Cryobiology 82 (2018): 15-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046809540&partnerID=MN8TOARS.
    10.1016/j.cryobiol.2018.04.014
  40. Guedes, A.F.; Carvalho, F.A.; Domingues, M.M.; Macrae, F.L.; McPherson, H.R.; Santos, N.C.; Ari¿ns, R.A.S.. "Sensing adhesion forces between erythrocytes and ¿’ fibrinogen, modulating fibrin clot architecture and function". Nanomedicine: Nanotechnology, Biology, and Medicine 14 3 (2018): 909-918. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042410370&partnerID=MN8TOARS.
    10.1016/j.nano.2018.01.006
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  98. Ribeiro, M.M.B.; Domingues, M.M.; Freire, J.M.; Santos, N.C.; Castanho, M.A.R.B.. "Translocating the blood-brain barrier using electrostatics". Frontiers in Cellular Neuroscience SEPTEMBER (2012): 1-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867062087&partnerID=MN8TOARS.
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  99. Martins, A.P.; Lopes, P.A.; Madeira, M.S.; Martins, S.V.; Santos, N.C.; Moura, T.F.; Prates, J.A.M.; Soveral, G.. "Differences in lipid deposition and adipose membrane biophysical properties from lean and obese pigs under dietary protein restriction". Biochemical and Biophysical Research Communications 423 1 (2012): 170-175. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862693223&partnerID=MN8TOARS.
    10.1016/j.bbrc.2012.05.108
  100. Martins, I.C.; Gomes-Neto, F.; Faustino, A.F.; Carvalho, F.A.; Carneiro, F.A.; Bozza, P.T.; Mohana-Borges, R.; et al. "The disordered N-terminal region of dengue virus capsid protein contains a lipid-droplet-binding motif". Biochemical Journal 444 3 (2012): 405-415. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862165670&partnerID=MN8TOARS.
    10.1042/BJ20112219
  101. Domingues, M.M.; Inácio, R.G.; Raimundo, J.M.; Martins, M.; Castanho, M.A.; Santos, N.C.. "Biophysical characterization of polymyxin B interaction with LPS aggregates and membrane model systems.". Biopolymers 98 4 (2012): 338-344. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872029556&partnerID=MN8TOARS.
  102. Gomes, I.; Feio, M.J.; Santos, N.C.; Eaton, P.; Serro, A.P.; Saramago, B.; Pereira, E.; Franco, R.. "Controlled adsorption of cytochrome c to nanostructured gold surfaces". Journal of Nanoparticle Research 14 12 (2012): 1-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869874481&partnerID=MN8TOARS.
    10.1007/s11051-012-1321-7
  103. Gonçalves, S.; Abade, J.; Teixeira, A.; Santos, N.C.. "Lipid composition is a determinant for human defensin HNP1 selectivity.". Biopolymers 98 4 (2012): 313-321. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872050769&partnerID=MN8TOARS.
  104. Franco, O.L.; Santos, N.C.. "Peptides from agribusiness to human health.". Biopolymers 98 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84872027202&partnerID=MN8TOARS.
  105. Domingues, M.M.; Santos, N.C.; Castanho, M.A.R.B.. "Antimicrobial peptide rBPI21: A translational overview from bench to clinical studies". Current Protein and Peptide Science 13 7 (2012): 611-619. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874879695&partnerID=MN8TOARS.
    10.2174/138920312804142101
  106. Padilla-Parra, S.; Matos, P.M.; Kondo, N.; Marin, M.; Santos, N.C.; Melikyan, G.B.. "Quantitative imaging of endosome acidification and single retrovirus fusion with distinct pools of early endosomes". Proceedings of the National Academy of Sciences of the United States of America 109 43 (2012): 17627-17632. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867907917&partnerID=MN8TOARS.
    10.1073/pnas.1211714109
  107. Eaton, P.; Zuzarte-Luis, V.; Mota, M.M.; Santos, N.C.; Prudêncio, M.. "Infection by Plasmodium changes shape and stiffness of hepatic cells". Nanomedicine: Nanotechnology, Biology, and Medicine 8 1 (2012): 17-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855332785&partnerID=MN8TOARS.
    10.1016/j.nano.2011.10.004
  108. Ascenso, A.; Guedes, R.; Bernardino, R.; Diogo, H.; Carvalho, F.A.; Santos, N.C.; Silva, A.M.; Marques, H.C.. "Complexation and full characterization of the tretinoin and dimethyl-ß-cyclodextrin complex.". AAPS PharmSciTech 12 2 (2011): 553-563. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861168025&partnerID=MN8TOARS.
    10.1208/s12249-011-9612-3
  109. Freire, J.M.; Domingues, M.M.; Matos, J.; Melo, M.N.; Veiga, A.S.; Santos, N.C.; Castanho, M.A.R.B.. "Using zeta-potential measurements to quantify peptide partition to lipid membranes". European Biophysics Journal 40 4 (2011): 481-487. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956016236&partnerID=MN8TOARS.
    10.1007/s00249-010-0661-4
  110. Carvalho, F.A.; de Oliveira, S.; Freitas, T.; Gonçalves, S.; Santos, N.C.. "Variations on fibrinogen-erythrocyte interactions during cell aging". PLoS ONE 6 3 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79953147017&partnerID=MN8TOARS.
    10.1371/journal.pone.0018167
  111. Franquelim, H.G.; Chiantia, S.; Veiga, A.S.; Santos, N.C.; Schwille, P.; Castanho, M.A.R.B.. "Anti-HIV-1 antibodies 2F5 and 4E10 interact differently with lipids to bind their epitopes". AIDS 25 4 (2011): 419-428. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951514918&partnerID=MN8TOARS.
    10.1097/QAD.0b013e328342ff11
  112. Castanho, M.; Santos, N.C.. "Peptide Drug Discovery and Development: Translational Research in Academia and Industry". Peptide Drug Discovery and Development: Translational Research in Academia and Industry (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-84869033333&partnerID=MN8TOARS.
    10.1002/9783527636730
  113. Martins, A.P.; Lopes, P.A.; Costa, A.S.H.; Martins, S.V.; Santos, N.C.; Prates, J.A.M.; Moura, T.F.; Soveral, G.. "Differential mesenteric fat deposition in bovines fed on silage or concentrate is independent of glycerol membrane permeability". Animal 5 12 (2011): 1949-1956. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955160624&partnerID=MN8TOARS.
    10.1017/S1751731111001091
  114. Rodrigues, M.; De La Torre, B.G.; Rádis-Baptista, G.; Santos, N.C.; Andreu, D.. "Efficient cellular delivery of ß-galactosidase mediated by NrTPs, a new family of cell-penetrating peptides". Bioconjugate Chemistry 22 11 (2011): 2339-2344. http://www.scopus.com/inward/record.url?eid=2-s2.0-81255189096&partnerID=MN8TOARS.
    10.1021/bc200421z
  115. Franquelim, H.G.; De-Sousa, F.F.; Veiga, A.S.; Santos, N.C.; Castanho, M.A.R.B.. "Cationic liposomes are possible drug-delivery systems for HIV fusion inhibitor sifuvirtide". Soft Matter 7 23 (2011): 11089-11092. http://www.scopus.com/inward/record.url?eid=2-s2.0-81355123272&partnerID=MN8TOARS.
    10.1039/c1sm06553j
  116. Franquelim, H.G.; Veiga, A.S.; Weissmüller, G.; Santos, N.C.; Castanho, M.A.R.B.. "Unravelling the molecular basis of the selectivity of the HIV-1 fusion inhibitor sifuvirtide towards phosphatidylcholine-rich rigid membranes". Biochimica et Biophysica Acta - Biomembranes 1798 6 (2010): 1234-1243. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952551415&partnerID=MN8TOARS.
    10.1016/j.bbamem.2010.02.010
  117. Santos, N.C.. "In and out - Biochemical and biophysical mechanisms of viral fusion and assembly". TheScientificWorldJournal 10 (2010): 419-421. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951761669&partnerID=MN8TOARS.
    10.1100/tsw.2010.53
  118. Santos, N.C.; Martins E Silva, J.; Freitas, T.; Doroana, M.; Duarte, N.; Tavares, L.; Antunes, F.; Saldanha, C.. "Blood cell membrane fluidity and intracellular Ca2+changes in antiretroviral-naïve and -treated HIV-1-infected patients". TheScientificWorldJournal 10 (2010): 350-355. http://www.scopus.com/inward/record.url?eid=2-s2.0-77749327970&partnerID=MN8TOARS.
    10.1100/tsw.2010.34
  119. Alves, C.S.; Melo, M.N.; Franquelim, H.G.; Ferre, R.; Planas, M.; Feliu, L.; Bardají, E.; et al. "Escherichia coli cell surface perturbation and disruption induced by antimicrobial peptides BP100 and pepR". Journal of Biological Chemistry 285 36 (2010): 27536-27544. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956238793&partnerID=MN8TOARS.
    10.1074/jbc.M110.130955
  120. Matos, P.M.; Castanho, M.A.R.B.; Santos, N.C.. "HIV-1 fusion inhibitor peptides enfuvirtide and T-1249 interact with erythrocyte and lymphocyte membranes". PLoS ONE 5 3 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956502249&partnerID=MN8TOARS.
    10.1371/journal.pone.0009830
  121. Matos, P.M.; Franquelim, H.G.; Castanho, M.A.R.B.; Santos, N.C.. "Quantitative assessment of peptide-lipid interactions. Ubiquitous fluorescence methodologies". Biochimica et Biophysica Acta - Biomembranes 1798 11 (2010): 1999-2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953139417&partnerID=MN8TOARS.
    10.1016/j.bbamem.2010.07.012
  122. Santiago, P.S.; Carvalho, J.W.P.; Domingues, M.M.; Santos, N.C.; Tabak, M.. "Thermal stability of extracellular hemoglobin of Glossoscolex paulistus: Determination of activation parameters by optical spectroscopic and differential scanning calorimetric studies". Biophysical Chemistry 152 1-3 (2010): 128-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149282480&partnerID=MN8TOARS.
    10.1016/j.bpc.2010.08.010
  123. Ribeiro, M.M.B.; Melo, M.N.; Serrano, I.D.; Santos, N.C.; Castanho, M.A.R.B.. "Drug-lipid interaction evaluation: Why a 19th century solution?". Trends in Pharmacological Sciences 31 10 (2010): 449-454. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956909526&partnerID=MN8TOARS.
    10.1016/j.tips.2010.06.007
  124. Matos, P.M.; Freitas, T.; Castanho, M.A.R.B.; Santos, N.C.. "The role of blood cell membrane lipids on the mode of action of HIV-1 fusion inhibitor sifuvirtide". Biochemical and Biophysical Research Communications 403 3-4 (2010): 270-274. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650172669&partnerID=MN8TOARS.
    10.1016/j.bbrc.2010.11.013
  125. Carvalho, F.A.; Connell, S.; Miltenberger-Miltenyi, G.; Pereira, S.V.; Tavares, A.; Ariëns, R.A.S.; Santos, N.C.. "Atomic force microscopy-based molecular recognition of a fibrinogen receptor on human erythrocytes". ACS Nano 4 8 (2010): 4609-4620. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650138418&partnerID=MN8TOARS.
    10.1021/nn1009648
  126. Martins, A.P.; Lopes, P.A.; Martins, S.V.; Madeira, A.; Santos, N.C.; Prates, J.A.M.; Moura, T.F.; Soveral, G.. "Conjugated linoleic acid reduces permeability and fluidity of adipose plasma membranes from obese Zucker rats". Biochemical and Biophysical Research Communications 398 2 (2010): 199-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955057876&partnerID=MN8TOARS.
    10.1016/j.bbrc.2010.06.059
  127. Santiago, P.S.; Carvalho, F.A.O.; Domingues, M.M.; Carvalho, J.W.P.; Santos, N.C.; Tabak, M.. "Isoelectric point determination for Glossoscolex paulistus extracellular hemoglobin: Oligomeric stability in acidic pH and relevance to protein-surfactant interactions". Langmuir 26 12 (2010): 9794-9801. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956081477&partnerID=MN8TOARS.
    10.1021/la100060p
  128. Domingues, M.M.; Lopes, S.C.D.N.; Santos, N.C.; Quintas, A.; Castanho, M.A.R.B.. "Fold-Unfold transitions in the selectivity and mechanism of action of the N-Terminal fragment of the bactericidal/permeability-increasing protein (rBPI21)". Biophysical Journal 96 3 (2009): 987-996. http://www.scopus.com/inward/record.url?eid=2-s2.0-61549096250&partnerID=MN8TOARS.
    10.1016/j.bpj.2008.10.044
  129. Domingues, M.M.; Castanho, M.A.R.B.; Santos, N.C.. "rBPI21 promotes lipopolysaccharide aggregation and exerts its antimicrobial effects by (hemi)fusion of PG-containing membranes". PLoS ONE 4 12 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-77949517357&partnerID=MN8TOARS.
    10.1371/journal.pone.0008385
  130. Vieira, C.R.; Castanho, M.; Saldanha, C.; Santos, N.C.. "Enfuvirtide effects on human erythrocytes and lymphocytes functional properties". Journal of Peptide Science 14 4 (2008): 448-454. http://www.scopus.com/inward/record.url?eid=2-s2.0-42149163387&partnerID=MN8TOARS.
    10.1002/psc.1006
  131. Matos, P.M.; Gonçalves, S.; Santos, N.C.. "Interaction of peptides with biomembranes assessed by potential-sensitive fluorescent probes". Journal of Peptide Science 14 4 (2008): 407-415. http://www.scopus.com/inward/record.url?eid=2-s2.0-42149117742&partnerID=MN8TOARS.
    10.1002/psc.1005
  132. Domingues, M.M.; Santiago, P.S.; Castanho, M.A.R.B.; Santos, N.C.. "What can light scattering spectroscopy do for membrane-active peptide studies?". Journal of Peptide Science 14 4 (2008): 394-400. http://www.scopus.com/inward/record.url?eid=2-s2.0-42149116252&partnerID=MN8TOARS.
    10.1002/psc.1007
  133. Santiago, P.S.; Moura, F.; Moreira, L.M.; Domingues, M.M.; Santos, N.C.; Tabak, M.. "Dynamic light scattering and optical absorption spectroscopy study of pH and temperature stabilities of the extracellular hemoglobin of glossoscolex paulistus". Biophysical Journal 94 6 (2008): 2228-2240. http://www.scopus.com/inward/record.url?eid=2-s2.0-44049099950&partnerID=MN8TOARS.
    10.1529/biophysj.107.116780
  134. Gomes, I.; Santos, N.C.; Oliveira, L.M.-A.; Quintas, A.; Eaton, P.; Pereira, E.; Franco, R.. "Probing surface properties of cytochrome c at Au bionanoconjugates". Journal of Physical Chemistry C 112 42 (2008): 16340-16347. http://www.scopus.com/inward/record.url?eid=2-s2.0-55649094472&partnerID=MN8TOARS.
    10.1021/jp804766v
  135. Franquelim, H.G.; Loura, L.M.S.; Santos, N.C.; Castanho, M.A.R.B.. "Sifuvirtide screens rigid membrane surfaces. Establishment of a correlation between efficacy and membrane domain selectivity among HIV fusion inhibitor peptides". Journal of the American Chemical Society 130 19 (2008): 6215-6223. http://www.scopus.com/inward/record.url?eid=2-s2.0-43249117737&partnerID=MN8TOARS.
    10.1021/ja711247n
  136. Gonçalves, S.; Santos, N.C.; Martins-Silva, J.; Saldanha, C.. "Fluorescence spectroscopy evaluation of fibrinogen-ß-estradiol binding". Journal of Photochemistry and Photobiology B: Biology 86 2 (2007): 170-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845567319&partnerID=MN8TOARS.
    10.1016/j.jphotobiol.2006.09.001
  137. Veiga, S.; Yuan, Y.; Li, X.; Santos, N.C.; Liu, G.; Castanho, M.A.R.B.. "Why are HIV-1 fusion inhibitors not effective against SARS-CoV? Biophysical evaluation of molecular interactions". Biochimica et Biophysica Acta - General Subjects 1760 1 (2006): 55-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-29044440663&partnerID=MN8TOARS.
    10.1016/j.bbagen.2005.10.001
  138. Martins-Silva, J.; Santos, N.C.; Doroana, M.; Duarte, N.; Tavares, L.; Antunes, F.; Saldanha, C.. "Changes in blood cell membrane properties in HIV type-1-infected patients". AIDS Research and Human Retroviruses 22 9 (2006): 849-853. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751026185&partnerID=MN8TOARS.
    10.1089/aid.2006.22.849
  139. Gonçalves, S.; Santos, N.C.; Martins-Silva, J.; Saldanha, C.. "Fibrinogen-ß-estradiol binding studied by fluorescence spectroscopy: Denaturation and pH effects". Journal of Fluorescence 16 2 (2006): 207-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646711479&partnerID=MN8TOARS.
    10.1007/s10895-005-0051-y
  140. Veiga, A.S.; Santos, N.C.; Castanho, M.A.. "An insight on the leading HIV entry inhibitors.". Recent patents on anti-infective drug discovery 1 1 (2006): 67-73. http://www.scopus.com/inward/record.url?eid=2-s2.0-39049093808&partnerID=MN8TOARS.
    10.2174/157489106775244046
  141. Santos, N.C.; Martins-Silva, J.; Saldanha, C.. "Gramicidin D and dithiothreitol effects on erythrocyte exovesiculation". Cell Biochemistry and Biophysics 43 3 (2005): 419-430. http://www.scopus.com/inward/record.url?eid=2-s2.0-27144489727&partnerID=MN8TOARS.
    10.1385/CBB:43:3:419
  142. Santos, N.C.; Martins-Silva, J.; Saldanha, C.. "PTEN "meets" DMSO". Leukemia Research 29 4 (2005): 361-362. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844272086&partnerID=MN8TOARS.
    10.1016/j.leukres.2004.09.009
  143. Saldanha, C.; Santos, N.C.; Martins-Silva, J.. "A colorimetric process to visualize erythrocyte exovesicles aggregates". Biochemistry and Molecular Biology Education 32 4 (2004): 250-253. http://www.scopus.com/inward/record.url?eid=2-s2.0-3242803480&partnerID=MN8TOARS.
    10.1002/bmb.2004.494032040374
  144. Santos, N.C.; Castanho, M.A.R.B.. "An overview of the biophysical applications of atomic force microscopy". Biophysical Chemistry 107 2 (2004): 133-149. http://www.scopus.com/inward/record.url?eid=2-s2.0-1242271244&partnerID=MN8TOARS.
    10.1016/j.bpc.2003.09.001
  145. Veiga, S.; Henriques, S.; Santos, N.C.; Castanho, M.. "Putative role of membranes in the HIV fusion inhibitor enfuvirtide mode of action at the molecular level". Biochemical Journal 377 1 (2004): 107-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642494594&partnerID=MN8TOARS.
    10.1042/BJ20031350
  146. Veiga, A.S.; Santos, N.C.; Loura, L.M.S.; Fedorov, A.; Castanho, M.A.R.B.. "HIV fusion inhibitor peptide T-1249 is able to insert or adsorb to lipidic bilayers. Putative correlation with improved efficiency". Journal of the American Chemical Society 126 45 (2004): 14758-14763. http://www.scopus.com/inward/record.url?eid=2-s2.0-8844228894&partnerID=MN8TOARS.
    10.1021/ja0459882
  147. Santos, N.C.; Figueira-Coelho, J.; Martins-Silva, J.; Saldanha, C.. "Multidisciplinary utilization of dimethyl sulfoxide: Pharmacological, cellular, and molecular aspects". Biochemical Pharmacology 65 7 (2003): 1035-1041. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037379110&partnerID=MN8TOARS.
    10.1016/S0006-2952(03)00002-9
  148. Santos, N.C.; Silva, A.C.; Castanho, M.A.R.B.; Martins-Silva, J.; Saldanha, C.. "Evaluation of Lipopolysaccharide aggregation by light scattering spectroscopy". ChemBioChem 4 1 (2003): 96-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037415015&partnerID=MN8TOARS.
    10.1002/cbic.200390020
  149. Santos, N.C.; Prieto, M.; Castanho, M.A.R.B.. "Quantifying molecular partition into model systems of biomembranes: An emphasis on optical spectroscopic methods". Biochimica et Biophysica Acta - Biomembranes 1612 2 (2003): 123-135. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038392423&partnerID=MN8TOARS.
    10.1016/S0005-2736(03)00112-3
  150. Saldanha, C.; Santos, N.C.; Martins-Silva, J.. "Fluorescent probes DPH, TMA-DPH and C17-HC induce erythrocyte exovesiculation". Journal of Membrane Biology 190 1 (2002): 75-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042266862&partnerID=MN8TOARS.
    10.1007/s00232-002-1025-5
  151. Santos, N.C.; Figueira-Coelho, J.; Saldanha, C.; Martins-Silva, J.. "Biochemical, biophysical and haemorheological effects of dimethylsulphoxide on human erythrocyte calcium loading". Cell Calcium 31 4 (2002): 183-188. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035992044&partnerID=MN8TOARS.
    10.1054/ceca.2002.0271
  152. Santos, N.C.; Fernandes, M.X.J.J.; Castanho, M.A.R.B.. "Overcoming angular dependency when teaching light scattering using a spectrofluorometer: The molecular weights of latex beads". Journal of Chemical Education 76 9 (1999): http://www.scopus.com/inward/record.url?eid=2-s2.0-0040886162&partnerID=MN8TOARS.
  153. Fernandes, M.X.J.J.; Santos, N.C.; Castanho, M.A.R.B.. "Continuous particle size distribution analysis with dynamic light scatteringMAXAMPER: A regularization method using the maximum amplitude for the average error and the Lagrange's multipliers method". Journal of Biochemical and Biophysical Methods 36 2-3 (1998): 101-117. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031776218&partnerID=MN8TOARS.
    10.1016/S0165-022X(98)00002-5
  154. Santos, N.C.; Ter-Ovanesyan, E.; Zasadzinski, J.A.; Castanho, M.A.R.B.. "Reconstitution of phospholipid bilayer by an atomic force microscope tip [2]". Biophysical Journal 75 4 (1998): 2119-2120. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031682589&partnerID=MN8TOARS.
  155. Santos, N.C.; Ter-Ovanesyan, E.; Zasadzinski, J.A.; Prieto, M.; Castanho, M.A.R.B.. "Filipin-induced lesions in planar phospholipid bilayers imaged by atomic force microscopy". Biophysical Journal 75 4 (1998): 1869-1873. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031690831&partnerID=MN8TOARS.
  156. Santos, N.C.; Prieto, M.; Castanho, M.A.R.B.. "Interaction of the major epitope region of HIV protein gp41 with membrane model systems. A fluorescence spectroscopy study". Biochemistry 37 24 (1998): 8674-8682. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032537597&partnerID=MN8TOARS.
    10.1021/bi9803933
  157. Santos, N.C.; Castanho, M.A.R.B.. "Erratum: (Biophysical Journal (1996) 71 (1641-1650))". Biophysical Journal 72 3 (1997): http://www.scopus.com/inward/record.url?eid=2-s2.0-0031055305&partnerID=MN8TOARS.
  158. Castanho, MARB; Santos, NC; Loura, LMS. "Separating the turbidity spectra of vesicles from the absorption spectra of membrane probes and other chromophores". European Biophysics Journal With Biophysics Letters 26 3 (1997): 253-259.
    10.1007/s002490050078
  159. Santos, N.C.; Sousa, A.M.A.; Betbeder, D.; Prieto, M.; Castanho, M.A.R.B.. "Structural characterization of organized systems of polysaccharides and phospholipids by light scattering spectroscopy and electron microscopy". Carbohydrate Research 300 1 (1997): 31-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030988131&partnerID=MN8TOARS.
    10.1016/S0008-6215(97)00025-6
  160. Santos, N.C.; Prieto, M.J.E.; Morna-Gomes, A.; Betbeder, D.; Castanho, M.A.R.B.. "Structural characterization (shape and dimensions) and stability of polysaccharide/lipid nanoparticles". Biopolymers 41 5 (1997): 511-520. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031127551&partnerID=MN8TOARS.
    10.1002/(SICI)1097-0282(19970415)41:5<511::AID-BIP3>3.0.CO;2-P
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Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2017 - 2023/03/10 Flavivirus capsid proteins interaction with host lipid systems and viral RNA
Co-supervisor
 Programa Doutoral do Centro Académico de Medicina de Lisboa (ramo de Medicina; ramo de Ciências Biomédicas; ramo de Ciências e Tecnologias da Saúde) (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015 - 2020/10/08 Design and mechanistic characterization of novel antimicrobial and anticancer peptides
Co-supervisor
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - 2020/04/17 Desenho racional de peptídeos análogos ao neuropeptídeo Y para o tratamento da obesidade
Co-supervisor of Beatriz Torres Meneguetti Mandruzzato
 Biotecnologia (PhD)
Universidade Católica Dom Bosco, Brazil
2014 - 2018/12/18 Enveloped viruses - a peptide inhibition strategy
Supervisor of Marcelo Alexandre da Costa Tavares Augusto
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2018/10/12 Characterization of enveloped viruses inhibition by 25-hydroxycholesterol at the membrane level
Supervisor of Bárbara Sofia Lopes Gomes
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2018/07/11 Molecular characterization of the fibrinogen-erythrocyte interaction as a cardiovascular risk
Supervisor of Ana Filipa Barata Duarte Guedes
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2012 - 2016/07/04 Dengue virus capsid protein structural and functional studies: a gateway for possible dengue inhibition strategies
Supervisor of André Filipe da Costa Faustino
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2008 - 2014/03/03 Molecular determinants of the celular internalization of crotamine-derived peptides
Supervisor of Margarida Filipe Dias Rodrigues
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - 2013/07/10 Shedding light on enveloped viruses entry and its inhibition using optical techniques
Supervisor of Pedro Miguel Baptista de Matos
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - 2012/12/19 Study of the mechanism of action of the antimicrobial peptide rBPI21 in Gram-negative bacteria
Supervisor of Marco André Manso Domingues
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - 2012/07/12 The role of lipid membranes in the mechanism of action of sifuvirtide and other HIV-1 fusion inhibitors
Co-supervisor of Henri Girão Franquelim
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - 2012/07/03 Studying single-molecule protein interactions and its biological and biomedical applications by AFM-based force spectroscopy
Supervisor of Filomena Maria Dias Almeida Carvalho Arede
 Ciências Biomédicas (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal

Association member

Society Organization name Role
2019/09/04 - Current Ambassador of the Biophysical Society (USA) Ambassador
2019/07/23 - Current Member of the Executive Committee of the European Biophysical Societies' Association (EBSA) Member
2018/03/27 - Current National Representative of Portugal at the European Peptide Society National Representative
2017/04/01 - Current Presidente da Mesa da Assembleia do Colégio de Química da Universidade de Lisboa Presidente da Mesa da Assembleia
2015/05/13 - 2021/11/05 President of the Portuguese Biophysical Society President
2008/10/01 - 2015/05/13 Treasurer of the Portuguese Biophysical Society Treasurer
Distinctions

Award

2023 ULisboa / Caixa Geral de Depósitos Prize (Biology, Biological Engineering, Biochemistry and Biotechnology)
Universidade de Lisboa, Portugal

Caixa Geral de Depositos, Portugal
2017 ULisboa / Caixa Geral de Depósitos Prize (Biology, Biological Engineering, Biochemistry and Biotechnology)
2005 Dr. José Luís Champalimaud Prize (Applied Research and Technologies area)
2004 Dr. José Luís Champalimaud Prize (Basic Research area)
2001 Programa Gulbenkian de Estímulo à Investigação
Fundação Calouste Gulbenkian, Portugal