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-----» Sofia Duque Santos is a Senior Post-Doctoral Researcher at the nanoBiomaterials for Targeted Therapies group (nBTT), at Instituto de Investigação e Inovação em Saúde (i3S), University of Porto. -----» SD Santos has a PhD degree in Biomedical Sciences (2005) at ICBAS and a Bsc degree in Biochemistry (2000) at FCUP. ----» SD Santos has authored 24 articles in high impact journals, ranging from Neurobiology, Pathology to the Biomaterials field. Her h-index is 14 and the 5-year impact factor is 6,5. Her research line is focused to therapeutic strategies in Stroke based on nanomaterials to deliver nucleic acids, using pre-clinical animal models. -----» SD Santos has participated in 7 funded projects (at national and international level) (2012-2015; 2016-2018; 2016-2020; 2019-2020; 2018-2020; 2017-2022; 2018-2022) as task leader or team member. -----» SD Santos has supervised or co-supervised more than 30 students in different levels, including 5 PhD students (2 ongoing), in projects related to neurological conditions and in cerebral protection for stroke. -----» As an invited teacher, SD Santos lectures for master and doctoral programs, at the Faculty of Medicine from the University of Porto. -----» Her awards include: 1 Ph.D. Fellowship (2001-2004); 3 Post-Doctoral Fellowships (2005-2008; 2008-2009; 2016-2018 ), 2 awards to attend an international scientific meeting (2010, 2017), 1st prize in Bioimaging photo competition (2016), 3rd prize in Biomedicine Photo, 2 prizes related to entrepreneurship in 2022 (Chaperone and iUP25kUP). -----» SD Santos contributes as opponent for PhD/MSc thesis examinations (17 since 2009). -----» SD Santos is an expert evaluator for a national (1) and international (4) funding agencies. SD Santos has also participated as an independent expert in various evaluation committees. Additionally, as a reviewer, she has been performing several revisions for distinct journals, since 2007. -----» As outreach activities, SD Santos has participated in: school visits (2010-2014); science fairs (2011-2014); Brain awareness week (BAW) 2011, 2014, 2020, 2021 and 2023; Science ambassador program (2010-2014 and 2016-present), Dopplegangers 2018 (Abcam); Openlab initiative (2020 and 2021), European Researcher night 2021, 2024 and Ciencia et al i3s educational program (2021 - present). -----» SD Santos has organized seminars at the national level (2010, 2011, 2021), one week course (2011), workshops (2021) and she was part of the organizing and scientific committee in 3 international scientific events (2019 and 2021). -----» In SD Santos' Ciência Vitae, the most relevant terms used are Health Sciences; Molecular Biology; Brain; Stroke; Cerebral neurorepair; Neurorestoration; Animal models; Nucleic acid therapies; Neurotherapeutics; Nanomaterials, Nanomedicine and RNAi.
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Identification

Personal identification

Full name
Sofia Santos

Citation names

  • Santos, Sofia Duque
  • Santos, SD
  • Duque Santos, S

Author identifiers

Ciência ID
CD1A-A923-7DC6
ORCID iD
0000-0002-8086-3310
Google Scholar ID
https://scholar.google.pt/citations?hl=en&user=2MZnSxAAAAAJ
Scopus Author Id
14058977000

Email addresses

  • sasantos@i3s.up.pt (Professional)
  • sasantos@ineb.up.pt (Professional)

Telephones

Telephone
  • 220408800 (Professional)

Addresses

  • Instituto de Investigação e Inovação em Saúde (i3S). Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Natural sciences - Biological Sciences - Behavioural Sciences Biology
  • Engineering and Technology - Nano-technology - Nano-materials

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Intermediate (B1) Upper intermediate (B2) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Intermediate (B1) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2) Intermediate (B1)
Portuguese (Mother tongue)
Education
Degree Classification
2005/10/04
Concluded
 NA (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"The stress response in transthyretin amyloidosis" (THESIS/DISSERTATION)
 Aprovado por unanimidade
2000/09
Concluded
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"The diazotrophic activity of Acetobacter Diazotrophicus: nitrogen protection from oxygen stress." (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2019/01/01 - Current Contracted Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/01/01 - 2018/12/31 Postdoc (Research) Instituto Nacional de Engenharia Biomédica, Portugal
2010/01/01 - 2014/06/30 Auxiliary Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2008/10/01 - 2009/06/30 Postdoc (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2005/10/01 - 2008/09/30 Postdoc (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2006/10/01 - 2006/12/15 Visiting Researcher (Research) Syddansk Universitet Institut for Molekylær Medicin, Denmark
2001/01/01 - 2005/09/30 Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2002/10/01 - 2002/11/30 Visiting Researcher (Research) Columbia University Department of Biochemistry and Molecular Biophysics, United States
2000/03/01 - 2000/08/31 Research Trainee (Research) Stockholms Universitet Institutionen för biokemi och biofysik, Sweden
Projects

Grant

Designation Funders
2018/09 - 2022/03 iDNArT - Intelligent DNA nanostructures aimed at brain therapeutics
iDNArT - PTDC/NAN-MAT/30898/2017
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciencia e a Tecnologia (FCT)
Concluded
2019 - 2021 Engineering Precision Bionanotheranostics
Cooperação Transnacional_DAAD - 2018
Post-doc
Ongoing
2018/11/01 - 2020/11/01 MECHANO - From the mechanobiology of the glial scar to the management of multiple sclerosis.
UTAP-EXPL/NTec/0057/2017
Other
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciencia e a Tecnologia (FCT)
Ongoing
2016/07 - 2020/07 BaiTS - Biodegradable dendrimers for Targeted neuroprotective therapies in Stroke.
PTDC/CTM-NAN/3547/2014.
Researcher
Fundação para a Ciencia e a Tecnologia (FCT)
2019/02/01 - 2019/10/21 From the mechanobiology of the glial to the management of multiple sclerosis
UTAP-EXPL/NTec/0057/2017
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/09 - 2018/09 nanoTerapias Neuroprotetoras avançadas para o tratamento de acidentes vasculares cerebrais.
FIS-FIS -2015-01_CCV_20150630-88
Researcher
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
INFARMED
Concluded
2012/02 - 2015/03 NeurON - Molecularly-designed hydrogels for neural stem cell transplantation: a combinatorial approach for successful regeneration and functional recovery in spinal cord injury
PTDC/SAU-BMA/118869/2010
Supervisor
Fundação para a Ciência e a Tecnologia
2003 - 2007 Mecanismos moleculares e celulares no metabolismo de lipoproteinas e de transtirretina
POCTI/BCI/49459/2002
PhD Student Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciencia e a Tecnologia (FCT)
2000 - 2004 A amiloidogénese na polineuropatia amiloidótica familiar: factores e prevenção
POCTI/CBO/35785/99
PhD Student Fellow
Fundação para a Ciencia e a Tecnologia (FCT)

Contract

Designation Funders
2018/05 - 2023/05 Advanced Integrative solutions to corrosion problems beyond micro-scale: towards long-term durability of miniaturized biomedical, electronic and energy systems.
764977 mCBEEs - H2020 MSCA ITN 2017
 N/A
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 2 - 2011-2012
PEst-C/SAU/LA0002/2011
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Marília Torrado; Silva, Duarte; Leiro, Victoria; Santos, Sofia Duque; Pêgo, Ana. "The empire strikes back: Biodegradable dendrimers as delivery vectors of neuroprotective therapies for stroke". Paper presented in 10th i3S annual meeting, Póvoa de Varzim, 2023.
  2. Marília Torrado; Leiro, Victoria; Santos, Sofia Duque; Pêgo, Ana Paula. "Biodegradable dendrimers for mRNA therapeutics: crossing the BBB of the ischemic brain". Paper presented in 32nd Annual Conference of the European Society for Biomaterials (ESB2022), Bordeaux, 2022.
  3. Martins, Ana S.G.; Reis, S.D.; Ruxandra Baboi; Cortinhas, João; Domingues, M.M.; Santos, N.C.; Santos, Sofia Duque; Pêgo, Ana Paula; Moreno, P.M.D.. Corresponding author: Moreno, P.M.D.. "Nucleic acid-based nanostructures functionalized with neurotrophin-mimetic aptamer aiming at neuronal targeting". Paper presented in 31st Conference of the European Society for Biomaterials (ESB), Porto, 2021.
  4. Santos, Sofia Duque; Saraiva MJ. "A compromised heat shock response increases systemic extracellular transthyretin deposition and affects the peripheral and autonomic systems: New model for familial amyloid polyneuropathy". Paper presented in Peripheral Nerve Society 2007 Biennial Meeting, Cliff Lodge Snowbird, Utah, 2007.
  5. Cerca F; Santos, Sofia Duque; Teixeira P.; Saraiva MJ. "Endoplasmic reticulum stress associated with protein extracellular aggregates: Evidence from transthyretin deposition in FAP". Paper presented in 11th International Symposium on Amyloidosis, Woods Hole, 2006.
Conference paper
  1. Torrado, Marília; Leiro, Victoria; Santos, Sofia Duque; Pêgo, Ana. "New Nanobiomaterials for Stroke Neuroprotection and Neurorecovery: A Novel Biodegradable Vector Applied In Vivo for mRNA Therapeutics". Paper presented in XLIV Congreso de la Sociedad Ibérica de Biomecánica y Biomateriales, Cáceres, 2022.
    Published
Conference poster
  1. Moreira, Débora; Santos, SD; Leiro, Victoria; Pêgo, Ana. "Dendrimers as Alzheimer´s Disease Nanotherapeutics: Exploring their Effect on Aß1-42 Fibrillation.". 2023.
  2. Moreira, Débora; Santos, Sofia Duque; Leiro, Victoria; Pêgo, Ana Paula. Corresponding author: Moreira, Débora. "The Potential of Dendrimers as Alzheimer's Disease Nanotherapeutics - Evidence of Antiamyloidogenic Properties Against Aß42". Paper presented in Alzheimer's Association International Conference (AAIC) 23, 2023.
  3. Marília Torrado; Leiro, Victoria; Santos, Sofia Duque; Pêgo, Ana Paula. Corresponding author: Marília Torrado. "Engineering Botulinum Neurotoxins towards an innovative neuroprotective nanosystem in the context of stroke". Paper presented in ETOX 2023 - European Workshop on Bacterial Protein Toxins, 2023.
  4. Custódio, Beatriz; Joana F Marques; Gomez-Lazaro, Maria; Maria M Azevedo; Santos, Sofia Duque; Pêgo, Ana Paula. "Swim upstream to tackle ischemic stroke: Zebrafish as an alternative model for neuroprotective nanoparticle screening". Paper presented in FENS Regional Meeting, 2023.
  5. Maria lopes; Marília Torrado; Santos, SD; Pêgo, Ana; João Borges; Mano, Joao F.. "Bioinstructive Peptide-based Supramolecular Multilayered Nanobiomaterials for Stimulating Neurite Outgrowth.". Paper presented in SupraLife First School - Functional Supramolecular Polymeric Biomaterials, 2023.
  6. Custódio, Beatriz; Marques, Joana; Gomez-Lazaro, Maria; Azevedo, Maria; Santos, Sofia Duque; Bessa, Jose; Pêgo, Ana Paula; et al. "THE UNDERWATER BATTLE TO TREAT ISCHEMIC STROKE: NEUROPROTECTIVE NANOPARTICLE SCREENING WITH ZEBRAFISH". Paper presented in 12th European Zebrafish Meeting, Krakow, 2023.
  7. Torrado, Marília; Sinthon, Clara; Leiro, Victoria; Santos, Sofia Duque; Pêgo, Ana Paula. Corresponding author: Torrado, Marília. "Biodegradable dendrimers as shuttles to neuroprotection: Final stop - the ischemic brain". Paper presented in 5th PhDay: Building Paths: The Science Behind Us, 2022.
  8. A MARTINS; Santos, SD; Moreno, Pedro; ana pego. "Exploring DNA nanostructures for neuronal cell delivery of nucleic acid drugs.". 2022.
  9. Custódio, Beatriz; Santos, SD; Pêgo, Ana Paula. "There is other fish in the sea: Zebrafish as an alternative model for nanoparticle screening in ischemic stroke". 2022.
  10. Torrado, Marília; Sinthon, Clara; Leiro, Victoria; Santos, Sofia Duque; Pêgo, Ana Paula. Corresponding author: Torrado, Marília. "Exploring biodegradable dendrimers as carriers of CNS neuroprotective therapeutics". Paper presented in 2nd International Meeting of the Portuguese Research Network on Spinal Cord Injury, 2022.
  11. Ana S. Martins; Santos, Sofia Duque; Moreno, Pedro; Pêgo, Ana. "Neuronal targeting with functionalized tetrahedral DNA nanostructures". Paper presented in 5th Functional DNA Nanotechnology., 2022.
  12. Gulino, Maurizio; Santos, SD; Pêgo, Ana. "Biocompatibility assessment of magnetoelectric cobalt ferrite CFO-BCZT nanoparticles for non-invasive deep brain stimulation". Paper presented in 31st Annual Conference of the European Society of Biomaterials, 2021.
  13. Moreira, Débora; Leiro, Victoria; Santos, SD; Pêgo, Ana; Custódio, Beatriz; Pêgo, Ana Paula. "Exploring the antiamyloidogenic properties of dendrimers for an Alzheimer's disease nanotherapy.". Paper presented in 31st Annual Conference of the European Society of Biomaterials. Porto, Portugal, 2021.
  14. Marília Torrado; Santos, SD; Pêgo, Ana. "Exploring a biodegradable dendrimer as carrier of neuroprotective mRNA to reach the ischemic brain". Paper presented in 31st Conference of the European Society for Biomaterials (ESB 2021). Porto, Portugal, 2021.
  15. Custódio, Beatriz; Joana F Marques; José Bessa; Santos, Sofia Duque; Pêgo, Ana Paula; Bessa J; Santos, SD. "If live gives you nanoparticles, screen them with zebrafish". Paper presented in 31st Conference of the European Society for Biomaterials (ESB), 2021.
  16. Custódio, Beatriz; Bessa J; Santos, SD; Pêgo AP. "SIZeD: Fishing through stroke: Novel neuroprotective nanomedicine targeting ischemic brain.". Paper presented in VII BiotechHealth Annual Symposium - BiotechDay. ICBAS, University of Porto, Portugal, 2021.
  17. Moreira, Débora; Leiro, Victoria; Santos, SD; Pêgo AP. "Dendrimers as nanotherapeutics for Alzheimer's disease.". Paper presented in 4th Doctoral Congress in Engineering. Porto, Portugal., 2021.
  18. Mota, Gil; Santos, SD; Pêgo, Ana. "Nanomedicine for stroke: polymeric carriers of neurotherapies towards the diseased brain. Polypeptide-based nanosystems and curcumin.". Paper presented in 14th Encontro de Investigação Jovem da Universidade do Porto (IJUP)., 2021.
  19. Martins ASG; Santos, SD; Domingues MM; Santos NC; Pêgo, Ana; Moreno, PMD. "Neuronal Targeted Nucleic-Acid Nanostructures aiming at Neurotherapies". Paper presented in World Biomaterials Congress 2020 (WBC 2020). Glasgow, United Kingdom., 2020.
  20. Torrado, Marília; Leiro, Victoria; Santos, Sofia Duque; Pêgo, Ana Paula. Corresponding author: Torrado, Marília. "Tackling the beginnings of DETOX: an innovative neuroprotective nanosystem". Paper presented in 3rd PhDay: Back to the Future, 2020.
  21. Custódio, Beatriz; Marques JF; Bessa J; Santos, SD; Pêgo AP. "Let the fish save the brain: Zebrafish as a model to screen nanoparticle delivery in ischemic brain.". Paper presented in 3rd PhDay - Back to the Future. i3S, Porto, Portugal., 2020.
  22. Torrado M; Santos, SD; Leiro, Victoria; Pêgo, Ana. "Tackling the beginnings of DETOX: an innovative neuroprotective nanosystem at the". Paper presented in 3rd PhDay Back to the Future. i3S Institute for Research and Innovation in Health, Porto (Portugal)., 2020.
  23. Borges, J; Barth D; Torrado M; Santos, SD; Cleymand F; Cinar G; Pêgo, Ana; Mano J. "Bottom-up supramolecular design of modular self-assembling biopolymeric multicomponent nanomaterials to orchestrate cell functions.". Paper presented in 8th EuChemS Chemistry Congress. Lisbon, Portugal, 2020.
  24. Torrado, Marília; Leiro V; Santos, Sofia Duque; Pêgo AP. "From bench to ischemic brain: Biodegradable dendrimers as novel tools to be applied as a neuroprotective strategy". Paper presented in 12th FENS Forum of Neuroscience, Glasgow, UK., 2020.
  25. Torrado, Marília; Leiro, Victoria; Santos, Sofia Duque; Pêgo, Ana Paula. Corresponding author: Torrado, Marília. "From bench to the ischemic brain: Biodegradable dendrimers as novel tools to be applied as a neuroprotective strategy". Paper presented in FENS 2020 Virtual Forum, 2020.
  26. Custódio, Beatriz; Bessa J; Santos, SD; Pêgo, Ana. "SIZeD - Fishing through stroke: Novel neuroprotective nanomedicine targeting ischemic brain.". Paper presented in VII BiotechHealth Annual Symposium - BiotechDay, ICBAS, University of Porto, Portugal., 2020.
  27. O’Neill K; Santos, Sofia Duque; Amaral IF; Pêgo AP. "Development of a neuron specific non-viral delivery system for Rho-Kinase 2 small interfering RNA". Paper presented in 8th i3S Annual Meeting, Póvoa de Varzim, Portugal, 2019.
  28. Santos, SD; Bola D; Teixeira S.; Sousa SS; Leiro V; Pêgo AP. "Unravelling the potential of chitosan derived nanoparticles for therapeutic synergism in stroke using antagomiR technology and neurotrophin mimetics". Paper presented in 8th i3S Annual Meeting. Póvoa de Varzim, Portugal, 2019.
  29. Custódio, Beatriz; Magalhães N.; Marques JF; Silva-Reis SC; Mota P; Leiro, V.; Bessa J; Santos, Sofia Duque; Pêgo AP. "The blood-brain barrier as a challenge to face in the delivery of nucleic acids mediated by dendrimers in brain ischemia". Paper presented in 8th i3S Annual Meeting. Póvoa de Varzim, Portugal, 2019.
  30. Santos, SD. "Functionalized Nucleic-Acid Nanostructures for Neuronal Targeting.". Paper presented in 8th i3S Annual Meeting. Póvoa de Varzim, Portugal., 2019.
  31. Leiro, V.; Santos, Sofia Duque; Spencer AP; Torrado, Marília; Custódio, Beatriz; Magalhães N.; Mota P.; Reis S.; Pêgo AP. "From Peripheral to Central Nervous System: A Journey Towards Targeted Neuronal Delivery". Paper presented in IDS11 - 11th International Dendrimer Symposium. Funchal, Madeira, Portugal., 2019.
  32. Borges J; Barth D; Torrado, Marília; Santos, Sofia Duque; Sousa M.; Cleymand F; Cinar G; et al. "Supramolecular design of self-assembling nanobiomaterials to direct cell fate". Paper presented in 47th IUPAC World Chemistry Congress, Paris, France, 2019.
  33. Martins ASG; Moreno PMD; Santos, Sofia Duque; Pêgo AP. "Neuronal Targeted Multifunctional DNA Nanostructures". Paper presented in 3rd Doctoral Congress in Engineering (DCE 2019), Faculdade de Engenharia, Universidade do Porto, Porto, Portugal, 2019.
  34. Custódio, Beatriz; Magalhães N.; Leiro V; Santos, Sofia Duque; Pêgo AP. "In vitro assessment of the blood-brain barrier permeation with dendrimers transporting nucleic acids in ischemia". Paper presented in Interrogations at the Biointerface - 7th Advanced Summer School: Do organoids fill the in vivo/in vitro gap?, Biblioteca Municipal Almeida Garrett, Porto, Portugal, 2019.
  35. O’Neill K; Santos, Sofia Duque; Amaral IF; Pêgo AP. "Development of a neuron specific non-viral delivery system for Rho-Kinase 2 short interfering RNA". Paper presented in Interrogations at the Biointerface, 7th Advanced Summer School: Do organoids fill the in vivo/in vitro gap?, Biblioteca Municipal Almeida Garrett, Porto, Portugal, 2019.
  36. Torrado, Marília; Leiro V; Santos, Sofia Duque; Pêgo AP. "Biodegradable dendrimers as delivery systems: developing a neuroprotective strategy to reach ischemic neurons". Paper presented in Interrogations at the Biointerface, 7th Advanced Summer School: Do organoids fill the in vivo/in vitro gap?, Biblioteca Municipal Almeida Garrett, Porto, Portugal, 2019.
  37. Santos, Sofia Duque; Xavier M; Leite DM; Moreira DA; Custódio, Beatriz; Torrado, Marília; Castro R.; et al. "The transport of therapeutic molecules to the ischemic brain: dendrimers as carriers in pre-clinical studies". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience. Lisbon, Portugal, 2019.
  38. Torrado, Marília; Leiro, V.; Santos, Sofia Duque; Pêgo AP. "Biodegradable dendrimers as novel tools to deliver neuroprotective nucleic acids in stroke". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN meeting 2019), Lisboa, Portugal, 2019.
  39. Custódio, Beatriz; Santos, Sofia Duque; Pêgo AP. "Delivery of nucleic acids in brain ischemia mediated by dendrimers: The challenge of crossing the blood-brain barrier". Paper presented in VII AEICBAS Biomedical Congress (ABC). Portugal, 2019.
  40. Martins ASG; Santos, Sofia Duque; Pêgo AP; Moreno PMD. "DNA Nanostructures as Potential Neuronal Targeting Carriers Envisioning Neurotherapies". Paper presented in VII AEICBAS Biomedical Congress (ABC). Porto, Portugal, 2019.
  41. Leiro V; Spencer AP; Magalhães N.; Torrado, Marília; Santos, Sofia Duque; Pêgo AP. "On the Fully Biodegradablity of PEG-Dendrimers for Nucleic Acids (siRNA & mRNA) Delivery". Paper presented in Tanja Weil Group Retreat. Ebernburg, Germany, 2019.
  42. Leiro V; Santos, Sofia Duque; Spencer AP; Magalhães N.; Torrado, Marília; Custódio, Beatriz; Pêgo AP. "Fully biodegradable PEG-dendrimers for nucleic acid delivery". Paper presented in MAD-Nano18 Madeira International Conference, Emerging trends and future of Nanomaterials for Human Health, Funchal, Portugal, 2018.
  43. Santos, Sofia Duque; Xavier M; Leite DM; Moreira DA; Custódio, Beatriz; Torrado, Marília; Castro R.; et al. "Blood-Brain Barrier Transport and Neuronal Uptake of PAMAM Dendrimers after Focal Brain Ischemia". Paper presented in 7th i3S Annual Meeting. Póvoa do Varzim, Portugal, 2018.
  44. Torrado, Marília; Santos, Sofia Duque; Leiro V; Pêgo AP; Leiro, Victoria. "Biological assessment of PEG based dendrimers for neuroprotective therapies in stroke in stroke". Paper presented in i3S annual meeting. Póvoa de Varzim, Portugal, 2018.
  45. Martins ASG; Santos, Sofia Duque; Pêgo AP; Moreno, PMD. "Developing Aptamer-functionalized DNA Nanostructures as a Potential Neurotropic Therapy". Paper presented in 7th i3S Annual Meeting, Póvoa de Varzim, Portugal., 2018.
  46. Santos, Sofia Duque; Xavier MA; Leite DM; Moreira DA; Castro R.; Leiro V; Rodrigues J.; Tomás H; Pêgo AP. "Nanoparticle-mediated Blood-Brain Barrier Transport for Neuronal Delivery in Focal Brain Ischemia". Paper presented in 10th International Symposium on Neuroprotection and Neurorepair. Dresden (Radebeul), Germany, 2018.
  47. Martins ASG; Santos, Sofia Duque; Pêgo AP; Moreno, PMD. "Aptamer functionalized DNA nanostructures for the development of potential neurotropic devices". Paper presented in 11º Encontro de Investigação Jovem da Universidade do Porto (IJUP). Porto, Portugal, 2018.
  48. Santos, Sofia Duque; Leiro V; Lopes CDF; Xavier MA; Leite D.; Tomás H; Pêgo AP. "PAMAM dendrimers as delivery vehicle in the injured ischemic brain". Paper presented in 6th i3S Annual Meeting, Póvoa de Varzim, Portugal, 2017.
  49. Santos, Sofia Duque; Leiro, V.; Lopes CDF; Xavier MA; Leite D.; Tomás H; Pêgo AP. "Blood-Brain Barrier Transport and Brain Uptake of Poly(Ethylene Glycol)-Modified PAMAM Dendrimers in brain ischemia". Paper presented in XV Meeting of the Portuguese Society for Neuroscience., Braga, Portugal, 2017.
  50. Santos, Sofia Duque; Leiro V; Lopes CDF; Xavier MA; Leite D.; Tomás H; Pêgo AP. "PEGylated PAMAM dendrimers can effectively reach the injured ischemic brain". Paper presented in 6th China-Europe Symposium on Biomaterials in Regenerative Medicine. CESB 2017, Porto, Portugal., 2017.
  51. Fonseca, AC; Bettencourt Relvas, João; Santos, SD. "The role of RhoA in stroke recovery.". Paper presented in XXIX Jornadas de Terapêutica. ICBAS. Porto, Portugal., 2017.
  52. Karabiyik C; Fernandes R.; Figueiredo FR; Brakebusch C; Lambertsen KL; Relvas JB; Santos, Sofia Duque. "Neuronal Rho GTPase Rac1 elimination confers neuroprotection in brain ischemia". Paper presented in 5th Symposium in Applied Bioimaging, Bioimaging 2016. Disease in focus. Porto, Portugal, 2016.
  53. Santos, Sofia Duque; Fonseca AC; Ribeiro TS; Abreu AA; Lambertsen KL; Relvas JB. "Dissecting RhoA contribution to neurodegeneration and neurorepair in brain ischemia". Paper presented in 7th International Symposium on Neuroprotection and Neurorepair. Potsdam, Germany., 2012.
  54. Rosa AI; Santos, Sofia Duque; Bernardino, L.; Chen TC; Relvas, J.; Malva JO; Hofman FM; Agasse F. "Heterocellular contacts with mouse brain endothelial cells via laminin-1 and alpha6 beta1 integrin sustains subventricular zone (SVZ) stem/progenitor cells properties". Paper presented in Society for Neuroscience 41st Annual Meeting, Washington DC, USA, 2011.
  55. Santos, Sofia Duque; Ribeiro T.; Lambertsen KL; Relvas JB. "Brain Ischemia and Rho GTPases". Paper presented in 5th Annual Meeting on Cell Signalling. Coimbra, Portugal, 2011.
  56. Santos, Sofia Duque; Neto F; Fonseca AC; Lambertsen KL; Ribeiro T.; Relvas JB. "Small Rho GTPases in Brain Ischemia". Paper presented in 6th International Symposium on Neuroprotection and Neurorepair. Cerebral Ischemia and Stroke. Rostock, Germany, 2010.
  57. Santos, Sofia Duque; Relvas JB. "Experimental models in the study of cerebral ischemia". Paper presented in 4th Portuguese Meeting for the Cerebrovascular Accident. Porto, Portugal., 2010.
  58. Magalhaes, Joana; Santos, Sofia Duque; Saraiva, Maria João. "aß-crystallin in Familial Amyloidotic Polyneuropathy". Paper presented in XII International Symposium on Amyloidosis, 2010.
  59. Santos, Sofia Duque; Lambertsen KL; Finsen B; Saraiva MJ. "A role for heat shock transcription factor 1 in focal cerebral ischemia in mice.". Paper presented in 5th International Symposium on Neuroprotection and Neurorepair. Cerebral Ischemia and Stroke. Magdeburg, Germany., 2008.
  60. Santos, Sofia Duque; Cardoso I.; Magalhães J.; Saraiva MJ. "Impairment of the Ubiquitin-Proteasome System associated with extracellular Transthyretin aggregates in Familial Amyloidotic Polyneuropathy". Paper presented in 2nd World Conference of Stress.. Budapest, Hungary., 2007.
    10.1002/path.2224
  61. Santos, Sofia Duque; Fernandes R.; Saraiva MJ. "An improved transgenic mouse for the study of familial amyloidotic polyneuropathy – hTTR V30M/HSF1.-KO: neuropathological characterization". Paper presented in 10th meeting of the Portuguese Society for Neurosciences. Ofir, Portugal., 2007.
  62. Santos, Sofia Duque; Saraiva MJ. "HSF1-KO mice expressing human mutant transthyretin V30M: a novel model for familial amyloidotic polyneuropathy". Paper presented in Society for Neuroscience 35th Annual Meeting, Washington DC, USA., 2005.
  63. Santos, Sofia Duque; Saraiva MJ. "Brain abnormalities of HSF1 null mouse". Paper presented in 33th annual meeting of the Society for Neuroscience. New Orleans, Lousiana, USA., 2004.
  64. Santos, Sofia Duque; Gottesman ME; Saraiva MJ. "Function of prokariotic TTR-like sequences". Paper presented in XIII Congresso Nacional de Bioquímica. Hotel Alfa, Lisboa, Portugal, 2002.
Journal article
  1. Correia, Ana Salomé; Torrado, Marília; Costa-Coelho, Tiago; Carvalho, Eva Daniela; Inteiro-Oliveira, Sara; Diógenes, Maria José; Pêgo, Ana Paula; et al. "Brain-derived neurotrophic factor modulation in response to oxidative stress and corticosterone: role of scopolamine and mirtazapine". Life Sciences 358 (2024): 123133. http://dx.doi.org/10.1016/j.lfs.2024.123133.
    10.1016/j.lfs.2024.123133
  2. Beatriz Custódio; Patrícia Carneiro; Joana Marques; Victoria Leiro; Ana M. Valentim; Mafalda Sousa; Sofia D. Santos; et al. "Biological Response Following the Systemic Injection of PEG–PAMAM–Rhodamine Conjugates in Zebrafish". Pharmaceutics 16 5 (2024): 608. https://doi.org/10.3390/pharmaceutics16050608.
    Published • 10.3390/pharmaceutics16050608
  3. Ana S. G. Martins; Sara D. Reis; Erik Benson; Marco M. Domingues; João Cortinhas; Joana A. Vidal Silva; Sofia D. Santos; et al. "Enhancing Neuronal Cell Uptake of Therapeutic Nucleic Acids with Tetrahedral DNA Nanostructures". Small (2024): https://doi.org/10.1002/smll.202309140.
    10.1002/smll.202309140
  4. Pereira, Raquel L.; Oliveira, Daniela; Pêgo, Ana P.; Santos, Sofia D.; Moreira, Felismina T.C.. "Electrochemical miRNA-34a-based biosensor for the diagnosis of Alzheimer’s disease". Bioelectrochemistry 154 (2023): 108553. http://dx.doi.org/10.1016/j.bioelechem.2023.108553.
    Published • 10.1016/j.bioelechem.2023.108553
  5. Débora A. Moreira; Sofia D. Santos; Victoria Leiro; Ana P. Pêgo. "Dendrimers and Derivatives as Multifunctional Nanotherapeutics for Alzheimer's Disease". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15041054.
    10.3390/pharmaceutics15041054
  6. Maria Lopes; Marília Torrado; Daryl Barth; Sofia D. Santos; Melike Sever-Bahcekapili; Ayse B. Tekinay; Mustafa O. Guler; et al. "Supramolecular presentation of bioinstructive peptides on soft multilayered nanobiomaterials stimulates neurite outgrowth". Biomaterials Science (2023): https://doi.org/10.1039/D3BM00438D.
    10.1039/D3BM00438D
  7. Gulino, Maurizio; Santos, Sofia Duque; Pêgo, Ana Paula. "Biocompatibility of Platinum Nanoparticles in Brain ex vivo Models in Physiological and Pathological Conditions". Frontiers in Neuroscience 15 (2021): http://dx.doi.org/10.3389/fnins.2021.787518.
    Published • 10.3389/fnins.2021.787518
  8. Spencer, Ana P.; Torrado, Marília; Custódio, Beatriz; Silva-Reis, Sara C.; Santos, Sofia D.; Leiro, Victoria; Pêgo, Ana P.. "Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the Central Nervous System". Pharmaceutics 12 2 (2020): 192. http://dx.doi.org/10.3390/pharmaceutics12020192.
    Published • 10.3390/pharmaceutics12020192
  9. Gulino, Maurizio; Kim, Donghoon; Pané, Salvador; Santos, Sofia Duque; Pêgo, Ana Paula. "Tissue Response to Neural Implants: The Use of Model Systems Toward New Design Solutions of Implantable Microelectrodes". Frontiers in Neuroscience 13 (2019): http://dx.doi.org/10.3389/fnins.2019.00689.
    10.3389/fnins.2019.00689
  10. Santos, Sofia D.; Xavier, Miguel; Leite, Diana M.; Moreira, Débora A.; Custódio, Beatriz; Torrado, Marília; Castro, Rita; et al. "PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal brain ischemia". Journal of Controlled Release 291 (2018): 65-79. http://dx.doi.org/10.1016/j.jconrel.2018.10.006.
    Published • 10.1016/j.jconrel.2018.10.006
  11. Cansu Karabiyik; Rui Fernandes; Francisco Rosário Figueiredo; Renato Socodato; Cord Brakebusch; Kate Lykke Lambertsen; João Bettencourt Relvas; Sofia Duque Santos. "Neuronal Rho GTPase Rac1 elimination confers neuroprotection in a mouse model of permanent ischemic stroke". Brain Pathology 28 4 (2018): 569-580. https://doi.org/10.1111/bpa.12562.
    10.1111/bpa.12562
  12. Leiro, V.; Santos, S.D.; Pêgo, A.P.. "Delivering siRNA with dendrimers: In vivo applications". Current Gene Therapy 17 2 (2017): 105-119. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027834551&partnerID=MN8TOARS.
    10.2174/1566523217666170510160527
  13. Leiro, V.; Duque Santos, S.; Lopes, C.D.F.; Paula Pêgo, A.. "Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine". Advanced Functional Materials (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85019665316&partnerID=MN8TOARS.
    10.1002/adfm.201700313
  14. Rosa, A.I.; Grade, S.; Santos, S.D.; Bernardino, L.; Chen, T.C.; Relvas, J.; Hofman, F.M.; Agasse, F.. "Heterocellular contacts with mouse brain endothelial cells via laminin and a6ß1 integrin sustain subventricular zone (SVZ) stem/progenitor cells properties". Frontiers in Cellular Neuroscience 10 DEC2016 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85007483072&partnerID=MN8TOARS.
    10.3389/fncel.2016.00284
  15. Gomes, J.R.; Nogueira, R.S.; Vieira, M.; Santos, S.D.; Ferraz-Nogueira, J.P.; Relvas, J.B.; Saraiva, M.J.. "Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia". Cell Death and Differentiation 23 11 (2016): 1749-1764. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982105742&partnerID=MN8TOARS.
    10.1038/cdd.2016.64
  16. Barateiro, A.; Miron, V.E.; Santos, S.D.; Relvas, J.B.; Fernandes, A.; ffrench-Constant, C.; Brites, D.. "Unconjugated Bilirubin Restricts Oligodendrocyte Differentiation and Axonal Myelination". Molecular Neurobiology 47 2 (2012): 1-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867505724&partnerID=MN8TOARS.
    10.1007/s12035-012-8364-8
  17. Santos, Sofia Duque; Lambertsen, Kate Lykke; Clausen, Bettina Hjelm; Akinc, Akin; Alvarez, Rene; Finsen, Bente; Saraiva, Maria Joao. "CSF transthyretin neuroprotection in a mouse model of brain ischemia". Journal of Neurochemistry 115 6 (2010): 1434-1444.
    10.1111/j.1471-4159.2010.07047.x
  18. Santos, Sofia Duque; Fernandes, Rui; Saraiva, Maria Joao. "The heat shock response modulates transthyretin deposition in the peripheral and autonomic nervous systems". Neurobiology of Aging 31 2 (2010): 280-289.
    10.1016/j.neurobiolaging.2008.04.001
  19. Magalhães, J.; Santos, S.D.; Saraiva, M.J.. "aB-crystallin (HspB5) in familial amyloidotic polyneuropathy". International Journal of Experimental Pathology 91 6 (2010): 515-521. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649515958&partnerID=MN8TOARS.
    10.1111/j.1365-2613.2010.00735.x
  20. Nunes, A.F.; Montero, M.; Franquinho, F.; Santos, S.D.; Malva, J.; Zimmer, J.; Sousa, M.M.. "Transthyretin knockout mice display decreased susceptibility to AMPA-induced neurodegeneration". Neurochemistry International 55 7 (2009): 454-457. http://www.scopus.com/inward/record.url?eid=2-s2.0-69349100059&partnerID=MN8TOARS.
    10.1016/j.neuint.2009.07.001
  21. Santos, Sofia Duque; Costa, Rita; Teixeira, Pedro Filipe; Gottesman, Max; Cardoso, Isabel; Saraiva, Maria Joao. "Amyloidogenic properties of transthyretin-like protein (TLP) from Escherichia coli". Febs Letters 582 19 (2008): 2893-2898.
    10.1016/j.febslet.2008.07.025
  22. Santos, S.D.; Magalhães, J.; Saraiva, M.J.. "Activation of the heat shock response in familial amyloidotic polyneuropathy". Journal of Neuropathology and Experimental Neurology 67 5 (2008): 449-455. http://www.scopus.com/inward/record.url?eid=2-s2.0-43249124993&partnerID=MN8TOARS.
    10.1097/NEN.0b013e31816fd648
  23. Santos, S.D.; Cardoso, I.; Magalhães, J.; Saraiva, M.J.. "Impairment of the ubiquitin-proteasome system associated with extracellular transthyretin aggregates in familial amyloidotic polyneuropathy". Journal of Pathology 213 2 (2007): 200-209. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348937731&partnerID=MN8TOARS.
    10.1002/path.2224
  24. Teixeira, P.F.; Cerca, F.; Santos, S.D.; Saraiva, M.J.. "Endoplasmic reticulum stress associated with extracellular aggregates: Evidence from transthyretin deposition in familial amyloid polyneuropathy". Journal of Biological Chemistry 281 31 (2006): 21998-22003. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746814859&partnerID=MN8TOARS.
    10.1074/jbc.M602302200
  25. Santos, S.D.; Saraiva, M.J.. "Enlarged ventricles, astrogliosis and neurodegeneration in heat shock factor 1 null mouse brain". Neuroscience 126 3 (2004): 657-663. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942525558&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2004.03.023
Thesis / Dissertation
  1. "Tracing the In Vivo Fate of Dendrimeric Nanoparticles after Stroke with Zebrafish". Master, Universidade do Porto Faculdade de Medicina, 2024.
  2. "Nervous Tissue Response to Smart Nanomaterials for Deep Brain Stimulation: studies in In Vitro and Ex Vivo Brain Models of Different Complexity". PhD, Universidade do Porto Faculdade de Engenharia, 2023.
  3. "miR-based biossensor for the detection of Alzheimer's Disease". Master, Universidade do Porto Faculdade de Engenharia, 2022.
  4. "Engineering therapeutic proteins to treat the ischemic brain". Master, Universidade de Aveiro Departamento de Química, 2022.
  5. "Nanobiomaterials for neuro regeneration". Master, Università degli Studi di Genova, 2022.
  6. "Nanomedicine for stroke: polymeric carriers of neurotherapies towards the diseased brain". Master, Universidade do Porto Faculdade de Medicina, 2022.
  7. Santos, SD. "Development of Neurotherapeutic Polyplexes for Oxidative Stress in Ischemic Stroke". Master, Universidade do Porto Instituto de Investigação e Inovação em Saúde, 2020.
  8. Santos, SD. "Development of a neuron specific non-viral delivery system for Rho-Kinase 2 short interfering RNA". Master, Universidade do Porto Instituto de Investigação e Inovação em Saúde, 2019.
  9. Santos, SD. "Delivery of neuroprotective nanoparticles in brain ischemia". Master, 2019.
  10. Santos, SD. "Delivery of nucleic acids in brain ischemia mediated by dendrimers: the challenge of crossing the blood brain barrier". Master, Universidade do Porto Instituto de Investigação e Inovação em Saúde, 2018.
  11. Santos, SD. "Trimethyl-Chitosan-based Polyplexes for Neurotrophin Mimicking in Brain Ischaemia". Master, Universidade do Porto Instituto de Investigação e Inovação em Saúde, 2017.
  12. Santos, SD. "Implementation of an in vitro blood-brain barrier model to study nanoparticle administration in stroke". Master, Universidade do Porto Instituto de Investigação e Inovação em Saúde, 2017.
  13. Santos, SD. "Aptamer functionalized DNA nanostructures for neuronal targeting and TrkB receptor activation". Master, Universidade do Porto Instituto de Investigação e Inovação em Saúde, 2017.
  14. Santos, SD. "Delivery of Rac1 RNAi in ischemic neurons". Master, Universidade do Porto Instituto de Investigação e Inovação em Saúde, 2017.
  15. Santos, SD. "Developmental response of the cerebrovasculature to inflammation". PhD, University of Oxford, 2017.
  16. Santos, SD. "Study of the Rho GTPase Rac1 in the pathological mechanism of brain ischemia". Master, Syddansk Universitet, 2015.
  17. Santos, SD. "SLICK RhoA mice in brain ischemia". Master, Universidade do Porto, 2012.
  18. Santos, SD. "The role of neuronal beta1 integrin in infarct formation after permanent focal brain ischemia". Degree, Universidade do Porto, 2012.
  19. Santos, SD. "The role of oligodendrocyte RhoA in cerebral ischemia". Degree, Universidade do Porto, 2011.
  20. Santos, SD. "siRNA for Rho GTPases in hypoxia induced in vitro". Degree, Universidade do Porto, 2010.
  21. Santos, Sofia Alexandra Duque. "The Stress response in transthyretin amyloidosis". PhD, 2005. http://hdl.handle.net/10216/10615.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/09/04 Biodegradable dendrimers for mRNA therapeutics: crossing the BBB of the ischemic brain. . 4-8/09/2022, Bordeaux, France. 32nd Conference of the European Society for Biomaterials (ESB 2022)
European Society for Biomaterials (France)
2022/07/24 Supramolecular engineering of modular ECM-like functional nanobiomaterials to instruct cell behavior. XXVI Encontro Nacional da Sociedade Portuguesa de Química
Faculdade de Ciências, Universidade do Porto (Portugal)
2022/06/28 A zebrafish model to screen nanoparticle delivery in ischemic stroke. IX BiotechHealth Annual Symposium
(Portugal)
2022/06/21 A zebrafish stroke model to screen neuroprotective nanoformulations. 21-22/6/2022. Porto Portugal. 8th Advanced Summer School. Interrogations at the biointerface: Fibrosis from mechanisms to the clinic.
i3S | Instituto de Investigação e Inovação em Saúde da Universidade do Porto (Portugal)
2021/09/05 Exploring a biodegradable dendrimer as carrier of neuroprotective mRNA to reach the ischemic brain. 31st Conference of the European Society for Biomaterials (ESB 2021). Porto, Portugal
European Society for Biomaterials (Porto, Portugal)
2021/05/18 O Cérebro na saúde e na doença. (H)a.. conversa com...
Laboratório aberto. Universidade do Porto. (Porto, Portugal)
2021/05/05 Nanomedicine for stroke: polymeric carriers of neurotherapies towards the diseased brain. Polypeptide-based nanosystems and curcumin. 14th Encontro de Investigação Jovem da Universidade do Porto (IJUP).
University of Porto (PORTO, Portugal)
2021 Take a chance on zebrafish: A model to screen nanoparticle delivery in ischemic stroke. PhDay 2021
i3S | Instituto de Investigação e Inovação em Saúde da Universidade do Porto (Porto, Portugal)
2020/10/28 Nanomedicine for the next era of RNA therapeutics in Stroke i3S seminar series
Instituto de Investigação e Inovação em Saúde - i3S (PORTO, Portugal)
2020/01/28 O cérebro a descoberto. (H)a.. conversa com...
Laboratório aberto. Universidade do Porto. (Porto, Portugal)
2019/09/25 PAMAM PEG-Dendrimers for neurotherapeutic delivery in stroke 1st Discoveries Forum on Regenerative and Precision Medicine.
(Porto, Portugal)
2019/05/22 The dynamic blood-brain barrier and the quest to find the entrance Advanced Course on In vitro models of biological barriers
Faculty of Pharmacy. Porto University. (Porto, Portugal)
2019/03 On the Fully Biodegradablity of PEG-Dendrimers for Nucleic Acids (siRNA & mRNA) Delivery Tanja Weil Group Retreat
(Ebernburg, Germany)
2018/11/29 Blood-Brain Barrier Transport and Neuronal Uptake of PAMAM Dendrimers after Focal Brain Ischemia. i3S annual meeting
(Póvoa de Varzim, Portugal)
2011/04/15 The Cerebrovascular Accident III Jornadas de Neurofisiologia da ESTSP_IPP. I International Conference of Neurophysiology
Escola Superior de Tecnologia da Saúde do Porto (Porto, Portugal)
2007/05/23 Protective role of HSF1 in the central nervous system. 10th meeting of the Portuguese Society for Neurosciences
(Porto, Portugal)
2005/09/24 HSF1-KO mice expressing human mutant transthyretin V30M: a novel model for Familial Amyloidotic Polyneuropathy The 2nd International Congress on Stress Responses in Biology and Medicine
(Tomar, Portugal)
2004/06/12 Brain abnormalities of HSF1 null mouse 8th meeting of the Portuguese Society for Neurosciences
(Curia, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020/12/01 - Current Multifunctional biodegradable dendrimers as therapeutics for Alzheimer's disease
Co-supervisor
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/09/01 - Current Nanomedicine for stroke: polymeric carriers of neurotherapies towards the diseased brain
Supervisor of Gil Mota
 Neurobiology (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2020/01 - Current Fishing through stroke: Novel neuroprotective nanomedicine targeting ischemic brain
Co-supervisor
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/09 - Current DETOX: an innovative neuroprotective nanosystem for the treatment of cerebrovascular accidents
Co-supervisor of Marília Torrado
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/05 - Current Organotypic brain slices as ex-vivo models for the study of the foreign body response to implantable microelectrodes
Co-supervisor
 Engenharia Biomédica (PhD)
Universidade do Porto Faculdade de Engenharia, Portugal
2021/10 - 2022/12 Engineering therapeutic proteins to treat the ischemic brain
Co-supervisor of Clara Sinthon
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/02 - 2022/10 miR-based biossensor for the detection of Alzheimer's Disease
Co-supervisor
Universidade do Porto Faculdade de Engenharia, Portugal
2021/09 - 2022/02 "Nanobiomaterials for neuro regeneration
Co-supervisor
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/09 - 2020/12/11 Development of Neurotherapeutic Polyplexes for Oxidative Stress in Ischemic Stroke
Supervisor
 Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/02 - 2019/10 Development of a neuron specific non-viral delivery system for Rho-Kinase 2 short interfering RNA
Co-supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/02 - 2019/09 Delivery Of Neuroprotective Nanoparticles In Brain Ischemia
Supervisor
 Engenharia Biomédica
Universidade do Porto Faculdade de Engenharia, Portugal
2017/07 - 2019/08 MSc researcher Fellow at Nanobiomaterials for Targeted Therapies group at INEB/i3S in the project "nanoTerapias Neuroprotetoras avançadas para o tratamento de acidentes vasculares cerebrais
Co-supervisor
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/02/02 - 2019/02/24 Preliminary studies of metal-organic framework composites for biomolecules delivery in vivo
Co-supervisor
2018/02 - 2018/09 Delivery of nucleic acids in brain ischemia mediated by dendrimers: the challenge of crossing the blood-brain-barrier
Supervisor
 Bioengenharia
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/01 - 2018/03 Microfluidic devices: applications using nanoparticles in targeted neuroprotective strategies
Co-supervisor
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/02 - 2017/10 Implementation of an in vitro blood-brain barrier model to study nanoparticle administration in stroke
Co-supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/02 - 2017/10 Aptamer functionalized DNA nanostructures for neuronal cell targeting and TrkB receptor activation
Co-supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/02 - 2017/10 Trimethyl-Chitosan-based Polyplexes for Neurotrophin Mimicking in Brain Ischaemia
Supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/10 - 2016/10 Modified-chitosan based nanoparticles for the delivery of Rac1 siRNA in neuronal ischemia
Supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/02 - 2015/02 MSc Researcher fellow at Nanobiomaterials for Targeted Therapies group at INEB in the project "Bioactivity of a neuron specific non-viral delivery system for Rho-kinase 1 and 2.
Co-supervisor
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/10 - 2015/02 Study of the Rho GTPase Rac1 in the pathological mechanism of brain ischemia
Supervisor
Faculty of Southern Denmark, Denmark
2012/11 - 2013/12 MSc Researcher fellow at NEWtherapies group at INEB in the project "Development and biological characterization of a neuron specific non-viral delivery system for anti-Rho-kinase 1 and 2 small interfering RNA (siRNA-ROCK1/2).
Co-supervisor
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012/12 - 2013 Developmental response of the cerebrovasculature to inflammation
Co-supervisor
 Biologia Básica e Aplicada (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2011/12 - 2012/09 SLICK RhoA mice in brain ischemia
Supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2012/02 - 2012/03 The role of neuronal beta1 integrin in infarct formation after permanent focal brain ischemia
Supervisor
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2011/03 - 2011/07 The role of oligodendrocyte RhoA in cerebral ischemia
Supervisor
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/03 - 2021/10 Workshops and seminars to promote wellbeing and mental health, using an interdisciplinary approach. Monthly events (2021/03 - 2021/10)
Other (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/09/24 - 2021/09/24 A temporary exhibition with hands-on experiments, science shows and quizzes, focused to sustainable development and research in the field of brain health. (2021/09/24 - 2021/09/24)
Exhibition (Co-organisor)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/03/15 - 2021/03/15 Opening of the Brain awareness week - Stress and Burnout: molecular and clinical perspectives. Conference to enlighten to importance of wellbeing and mental health in the research work context. (2021/03/15 - 2021/03/15)
Symposium (Member of the Organising Committee)
2020/03/16 - 2020/03/18 Workshop with 5 research workstations related to the brain for young students . Integrated in the "Brain Awarness Week" from Dana Foundation. http://www.cienciaviva.pt/divulgacao/semanacerebro2020/list.asp?accao=inscrever&tipoaccao=1&id_cerebroaccao=376 (2020/03/16 - 2020/03/18)
Workshop (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2011/06/02 - 2011/06/02 Mini-symposium: Stroke - Neuropathology and Neurorecovery, in the Course: Molecular Neuropathology and Neurorepair Graduate Program in Areas of Basic and Applied Biology (GABBA). University of Porto. (2011/05/30 - 2011/06/03) Universidade do Porto, Portugal
2010/09/03 - 2010/09/03 Seminar: Protective neuroinflammation in ischemic-induced neuroregeneration. Lecturer: Kate Lykke Lambertsen. Friday Noon Seminars, IBMC. (2010/09/03 - 2010/09/03) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/06/14 - Current TRANSLATION FROM BENCH TO BEDSIDE FOR SPINAL CORD INJURY:WHAT ARE THE MANY STEPS OF DRUG DEVELOPMENT AND CLINICAL TRIAL PLANNING?
Workshop
 TRANSLATION FROM BENCH TO BEDSIDE FOR SPINAL CORD INJURY:WHAT ARE THE MANY STEPS OF DRUG DEVELOPMENT AND CLINICAL TRIAL PLANNING?
Universidade do Porto Faculdade de Medicina, Portugal
2023/04 - 2023/06 Online Advanced Course on Biomedical Imaging 2023. 8 sessions.
Workshop
 Online Advanced Course on Biomedical Imaging 2023
Universidade de Coimbra Faculdade de Medicina, Portugal
2023/03/29 - 2023/03/29 Tech4innov: o Presente e o Futuro da Inovação, promovido pela Agência Nacional de Inovação. Santa Maria da Feira. Portugal
Exhibition
 Tech4innov: o Presente e o Futuro da Inovação
Agência Nacional de Inovação SA, Portugal
2023/03/17 - 2023/03/19 XIV Symposium on Bioengineering, Conference panel chair “Neuro-On to something.
Congress
 XIV Symposium on Bioengineering
Universidade do Porto Faculdade de Engenharia, Portugal
2023/02/07 - 2023/02/07 Imaris | AI Powered Filament Tracer for Neurons, Blood Vessels, and Cellular Components. Organization: Oxford instruments.
Workshop
2022/10/12 - 2022/10/12 World Stroke Academy Webinar: Effective Management of Post-Stroke Spasticity.
Seminar
 World Stroke Academy Webinar: Effective Management of Post-Stroke Spasticity.
2022/10/06 - 2022/10/06 Women's Brain Project: project updates
Seminar
2022/09/16 - 2022/09/16 Building a Synthetic Biology Platform for Drug Delivery. Organization: The Scientist.
Seminar
2022/07/25 - 2022/07/25 N=1 Collaborative Workshop: Preclinical Design and Testing of Individualized Antisense Oligonucleotides. Organization: The N1C Seminar Series
Seminar
 N=1 Collaborative Workshop: Preclinical Design and Testing of Individualized Antisense Oligonucleotides
2022/06/13 - 2022/06/14 2nd International meeting of the portuguese research network on spinal cord injury. Centro de Investigação Médica da Faculdade de Medicina da Universidade do Porto
Symposium
 2nd International meeting of the portuguese research network on spinal cord injury
Universidade do Porto Faculdade de Medicina, Portugal
2022/05/26 - 2022/05/26 Amplifying the Future of Vaccine Development with saRNA
Seminar
Precision NanoSystems Inc, Canada
2022/05/19 - 2022/05/23 8º edição do Concurso de Ideias de Negócio da Universidade do Porto - iUP25k. Bip Ignition, programa de capacitação (Bten). FEP, UPTEC, Univ. Porto.
Other
 Ideias de Negócio da Universidade do Porto
Universidade do Porto Faculdade de Economia, Portugal
2022/05/16 - 2022/05/16 Peer Review course. Researcher Academy Certificate (Elsevier). Online
Other
 Peer Review course
Editions Scientifiques Elsevier, France
2022/05/04 - 2022/05/06 Beyond the lab Entrepreneurship bootcamp for scientists. Organization: Chaperone. UPTEC and Fraunhofer Aicos.
Other
 Beyond the lab Entrepreneurship bootcamp for scientists
UPTEC Associação de Transferência de Tecnologia da Asprela, Portugal
2022/04/28 - 2022/04/28 Modular and adaptive self-assembling dendrimers for nucleic acid delivery. Understanding nanoparticles through endocytic profiling. DARTER Virtual Seminar. Organization: DARTER COST action. Online.
Seminar
 Modular and adaptive self-assembling dendrimers for nucleic acid delivery.
2022/04/12 - 2022/04/12 ABC-RI International Forum Spring Edition 2022 - Gene and Cell Therapies for Healthy Ageing.
Conference
 ABC-RI International Forum Spring Edition 2022 - Gene and Cell Therapies for Healthy Ageing.
Universidade do Algarve Centro Académico de Investigação e Formação Biomédica do Algarve, Portugal
2022/04/06 - 2022/04/09 13th Symposium "Behind and Beyond the Brain".
Conference
 13h Symposium “Behind and Beyond the Brain”.
Fundação Bial, Portugal
2022/02/22 - 2022/02/22 Animal welfare during procedures. Instituto de Investigação e Inovação em Saúde (i3S). Online.
Workshop
 Animal welfare during procedures
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/02/09 - 2022/02/09 Scale-up and Manufacturing of Self-amplifying RNA-LNPs for a COVID-19 Vaccine. Online webinar
Seminar
2022/02/08 - 2022/02/08 Harnessing microRNAs for Cancer Therapeutics. Webinar Online.
Seminar
2021/11/23 - 2021/11/25 Spanish & Portuguese Advanced Optical Microscopy Meeting 2021 (SPAOM 2021).
Congress
 Spanish & Portuguese Advanced Optical Microscopy Meeting 2021 (SPAOM 2021).
2021/11 - 2021/11 Smart materials and Technologies in Regenerative medicine
Congress
 European Technology Platform for Nanomedicine
2021/11 - 2021/11 Translational Application of Biomaterials
Congress
 Translational Application of Biomaterials.
Flossie Wiley Elementary School, United States
2021/09/28 - 2021/09/28 Animal training webinar. Instituto de Investigação e Inovação em Saúde (i3S). Online.
Seminar
 Animal training webinar
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/07/19 - 2021/07/21 Delivery of Antisense RNA Therapeutics DARTER Virtual Workshop. Organization: DARTER COST action. Online.
Workshop
 Delivery of Antisense RNA Therapeutics DARTER Virtual Workshop
2021/06/21 - 2021/06/21 Science Communication Workshop. Organization: Soapbox Science. Online.
Workshop
 Science Communication Workshop
2021/05/27 - 2021/05/27 Course on BioImage Analysis for High Content Screening. Module 3. Cell profiler software.
Workshop
 BioImage Analysis for High Content Screening
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/05/27 - 2021/05/27 Course on BioImage Analysis for High Content Screening - module 3. Online.
Workshop
 BioImage Analysis for High Content Screening
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/02/10 - 2021/02/12 18th Advanced Imaging Methods Workshop 2021. Organization: Becker & Hickl. Online.
Workshop
 18th Advanced Imaging Methods
2019/12/04 - 2019/12/06 Course in experimental design and analysis of data for research with animals, 2nd edition
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/01/16 - 2019/01/18 NanoGateway Winter School 2019 - Nanotechnology for Therapy and Diagnostics
2018/03/19 - 2018/03/20 Applied Statistical Methods with R: Analysis of Variance - Module 2
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/10/19 - 2017/10/20 INL Summit. Nanotechnology: The New Economy. Braga, Portugal
2016/09/28 - 2016/09/30 Hands-on workshop on Image Analysis for Imaging flow Cytometry
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/01/16 - 2016/01/16 Workshop on Responsible Conduct of Research
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/06/11 - 2015/06/11 Entrepreneurship in the field of regenerative medicine: challenges and opportunities
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
2014/09/24 - 2014/09/24 Importância da Propriedade Industrial e Requisitos de Patenteabilidade
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
2014/05/06 - 2014/05/06 Workshop: Laboratory Animal Diseases and Pathology
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2013/09/25 - 2013/09/25 Training session: Mice and Rat Intravenous Injection
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2011/11/03 - 2011/11/03 Workshop: Communicating Animal Research
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2011/11 - 2011/11 FDA Guidance: Drug Products Containing Nanomaterial.
Congress
 COST
2010/11 - 2010/11 Bioinformatics course: Human Genome Bioinformatics
Instituto Gulbenkian de Ciência, Portugal
2010/10/18 - 2010/10/22 Harvard Medical School Workshop: Animal Models in Neuroscience
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2006/09/04 - 2006/09/15 FELASA category C in Laboratory Animal Science, certified by “Direção Geral de Veterinária”. Instituto de Investigação em Ciências da Vida e Saúde, Universidade do Minho, Braga, Portugal.
Universidade do Minho, Portugal
2005/07/05 - 2005/07/10 FENS/Blackwell Summer School, "Neuro-glia Interaction in Aging and Disease", Ofir, Portugal.
2004/06/03 - 2004/06/04 Introduction to Rodent Behaviour Testing: theory and applications
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/09/22 Synthesis of Sugar-coated Marine Polymeric Nanosystems for Topical Delivery of Bioactive Agents
(Thesis) Main arguer
 Filipa Serrasqueiro (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2020/12 Participation of Transthyretin in angiogenesis: biological and pathologic involvement
(Thesis) Main arguer
 Joana do Amaral Saavedra (Master)
Universidade de Aveiro Departamento de Biologia, Portugal
2020/11/09 The key role of periostin on bone metastatic niche and sensory neuron crosstalk
(Thesis) Main arguer
 Beatriz Silva Moura (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2019/10 Two birds, one study: evaluating the therapeutic potential of amphibian ocellatin-PT4 and -PT9 peptides for application in leishmaniasis and neuroinflammation-related diseases
(Thesis) Main arguer
 Anabela Moreira (Master)
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019 Control of microglia morphodynamics by the small RhoGTPase RhoA
(Thesis) Main arguer
 Francisco Nascimento (Master)
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/11/23 Birds of a (Different) Feather: PINCH1- and PINCH2-Mediated Signaling in CNS Myelination
(Thesis) Main arguer
 Raquel Sofia do Vale Silva (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2018/10 TTR-induced cytoskeleton remodelling: a double-edged sword
(Thesis) Main arguer
 Nídia Sampaio Macedo (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2018/01/23 Carbon Monoxide Modulation of Astrocytic Viability Following an Ischemic Injury. Metabolic Targets Disclosure
(Thesis) Main arguer
 Sara Raquel Reis de Oliveira (PhD)
Universidade de Coimbra, Portugal
2017/02/07 Regulation of the Ubiquitin-Proteasome System in brain ischemia impact on the neuronal proteome
(Thesis) Main arguer
 Ivan Lalanda Salazar (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2016/07/25 Dissecting the role of Transthyretin on neuritogenesis: impact on axonal transport?
(Thesis) Main arguer
 Inês Pires (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/07/24 In vitro ischemia-induced changes in the transcriptome of hippocampal neurons. Neuroprotective pathways in brain ischemia Joana Fernandes (PhD)
Universidade de Coimbra, Portugal
2013/12/30 Modulation of GABAA Receptors in Cerebral Ischemia: alterations in receptor trafficking coupled to neuronal death after oxygen/glucose deprivation Miranda Mele (PhD)
Universidade de Coimbra, Portugal
2013/10/21 Establishment of a Cell Culture System to Obtain Homogeneously Sized Neurospheres of Embryonic Stem Cell derived Neural Stem/Progenitor Cells Tiago Laundos dos Santos (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2013/07/05 Characterization of modulators of axonal regeneration: evaluation of myelin lipids and of chitosan scaffold-mediated cell-based therapy Marlene Morgado (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2009/11/24 Genetic characterization of Portuguese families with Dominantly Inherited Spastic Paraplegia: Pathogenic Mechanisms mediated by Atlastin-1 Mutants Ana Filipa Brandão (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2023 - 2023 Antioxidants (2076-3921) MDPI
2023 - 2023 Journal of Integrative Neuroscience (0219-6352) World Scientific Publishing
2022 - 2022 Cells (2073-4409) MDPI
2022 - 2022 Pharmaceutics (1999-4923) MDPI
2021 - 2021 Frontiers in Molecular Biosciences (2296-889X ) Frontiers
2019 - 2021 Biomedicine & Pharmacotherapy (0753-3322) Elsevier
2018 - 2021 Neurochemical Research (0364-3190 (print); 1) Springer
2018 - 2020 Biomaterials ( 0142-9612) Elsevier
2017 - 2017 PLOS ONE (1932-6203) Plos

Association member

Society Organization name Role
2021 - Current Sociedade Portuguesa de Neurociências Efective Member
2020/02 - Current Portugal AVC
2010 - Current National Association of Researchers in Science and Technology (ANICT)

Committee member

Activity description
Role 		Institution / Organization
2021 - Current Member of the i3S Animal Welfare and Ethics Body - ORBEA
Member
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/03/15 - 2021/03/15 Opening of the Brain awareness week. Conference to enlighten to importance of wellbeing and mental health in the research work context.
Coordinator
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021 - 2021 Member of the Steering Committee for the human research excellence award, based on the Human Resources Strategy for Researchers (HRS4R) from the European commission.
Member
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Conference scientific committee

Conference name Conference host
2023/03/19 - 2023/03/19 XIV Symposium on Bioengineering | Neuro-On to something Faculdade de Engenharia da Universidade do Porto
2021/07/08 - 2021/07/09 1st symposium on Oligonucleotide Technologies and Therapeutics
2019/06/27 - 2019/06/28 Interrogations at the Biointerface - 7th Advanced Summer School

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2017 - Current Experimental models in Neuroscience - Master in Neurobiology. Neurobiologia (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2008 - Current Methodological approaches in Neurosciences - Neuroscience Doctoral program Neurociências (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2019/05/22 - 2019/05/22 Advanced Course on In vitro models of biological barriers. Title: The dynamic blood-brain barrier and the quest to find the entrance. (Pós-Graduação) Universidade do Porto Faculdade de Farmácia, Portugal
2017 - 2018 Invited lecturer at Workshop on Neuroscience. V AEICBAS Biomedical Congress, years 2017 and 2018 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/04/27 - 2017/04/28 Invited lecturer at Workshop on Neuroengineering: Revealing, Repairing & Enhancing Brains (Basics of Neuronal Cell Cultures) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/07/09 - 2013/07/13 Neurodegeneration and Neurorepair in Stroke - Graduate Program in Areas of Basic and Applied Biology (GABBA). University of Porto. GABBA- programa graduado em áreas da biologia basica e aplicada (Doutoramento) Universidade do Porto, Portugal
2011/10/19 - 2011/10/21 Brain Ischemia - Animal Models, Methods and Assessments. Excitotoxic Signaling graduate Course. Doctoral Programme in Experimental Biology and Biomedicine Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/05/30 - 2011/06/03 Stroke: Molecular Neuropathology and Neurorepair - Graduate Program in Areas of Basic and Applied Biology (GABBA). GABBA-programa graduado em áreas da biologia basica e aplicada (Doutoramento) Universidade do Porto, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2023/07 - 2023/09 International expert evaluator for M-ERA.NET Call 2023
Evaluator
 European Union's Research and Innovation
2023 - 2023 International expert evaluator for FWO postdoctoral fellowship. European Science Foundation.
Evaluator
 European Science Foundation, France European Science Foundation
2022 - 2022 Independent evaluator for «Comissão de avaliação das bolsas excecionais»
Evaluator
 Fundação para a Ciência e a Tecnologia
2021/04 - 2021/04 Abstracts evaluation for the 31st Conference of the European Society for Biomaterials (ESB 2021) scientific programme
Evaluator
 European Society for Biomaterials, France European Society for Biomaterials
2021 - 2021 International expert evaluator for UNA4CAREER fellowship program for the Universidad Complutense de Madrid
Evaluator
 Universidad Complutense de Madrid, Spain
2020/06 - 2020/06 Member of the PhD Advisory Committee. Title: Mimicking the bone in a 3D compartmentalized microfluidic chip to fight cancer associated bone pain. Student: Andrea Bortolin. Supervisor: Meriem Lamghari.
Evaluator
 Universidade do Porto, Portugal
2020 - 2020 International external evaluator for the Narodowe Centrum Nauki - National Science Centre, Poland, in the life sciences field.
Evaluator
 Narodowe Centrum Nauki, Poland
2019/09/26 - 2019/09/26 Abstracts evaluation for the 2nd PhDay - PhD countdown: a time for Science. Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018 - 2018 Evaluation committee for Biotech Health Doctoral program. Candidate selection. University of Porto Universidade do Porto, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2019 - 2021 Biomedicine & Pharmacotherapy (0753-3322) Elsevier
2018 - 2021 Neurochemical Research (1573-6903) Springer-Verlag
2018 - 2021 Journal of Biomaterials (2640-2602) Science Publishing Group
2020 - 2020 Frontiers in Molecular Biosciences (2296-889X)
2017 - 2017 PLoS ONE (1932-6203) Public Library of Science

Mentoring / Tutoring

Topic Student name
2019 - 2019 Federation for European Laboratory Animal Science Assocation (FELASA) course Helena Ferreira
2016/09 - 2017/01 Bioengineer Group of students
2017 - 2017 Federation for European Laboratory Animal Science Assocation (FELASA) course Marília Torrado
2015/09 - 2016/01 Bioengineer Group of students
2016 - 2016 Federation for European Laboratory Animal Science Assocation (FELASA) course Eva Carvalho

Other jury / evaluation

Activity description Institution / Organization
2023/07 - 2023/09 International expert evaluator for M-ERA.NET Call 2023 European Union's Research and Innovation, Belgium
2023 - 2023 International expert evaluator for FWO postdoctoral fellowship European Science Foundation, France
2021/04 - 2021/06 International expert evaluator for UNA4CAREER fellowship program for the Universidad Complutense de Madrid Universidad Complutense de Madrid, Spain
2021 - 2021 National Advisory Committee member and external evaluator of abstracts for the 31st Conference of the European Society for Biomaterials (ESB 2021) scientific programme European Society for Biomaterials, France
2020/04 - 2020/04 International external evaluator for the National Science Centre Poland, in the life science field. Narodowe Centrum Nauki, Poland
2016 - 2020 Jury member for selection of fellows in different projects at i3S/INEB. Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015 - 2020 External Reviewer of scientific projects in a national scientific agency - ANI
2012 - 2014 Jury member for selection of fellows in different projects at the Institute for Molecular and Cell Biology - IBMC Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Distinctions

Award

2022 2nd prize in Beyond the lab - Entrepreneurship Bootcamp for Scientists
2022 2nd prize in 8th edition Concurso de Ideias de Negócio da Universidade do Porto
Universidade do Porto, Portugal
2022 3rd prize in FLAMIN-GO photo contest
Horizon 2020, Belgium
2017 Researchers Travel Grants
2016 1st prize in the the Bioimaging Scientific Photo Competition 2016.
Instituto Nacional de Engenharia Biomédica, Portugal
2010 Award to attend the international meeting 6th International Symposium on Neuroprotection and Neurorepair
Fundação Calouste Gulbenkian, Portugal