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Identification

Personal identification

Full name
Sónia Patrícia Dias Duarte

Citation names

  • Duarte, S.P.
  • Duarte S.
  • Sónia P. Duarte

Author identifiers

Ciência ID
CD1E-CEC0-AFFC

Email addresses

  • sonia.duarte@cnc.uc.pt (Professional)

Telephones

Telephone
  • 239820190 (Professional)

Addresses

  • Centro de Inovação em Biomedicina e Biotecnologia (CIBB)/Centro de Neurociências e Biologia Celular (CNC). Universidade de Coimbra, Rua Larga, Faculdade de Medicina Pólo I, 1º andar, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Websites

Education
Degree Classification
2023/03/08 - 2023/03/08
Concluded
Webinar on Enabling and advancing mRNA-LNP medicines from concept to clinic (VACCINE INSIGHTS) (Outros)
Bioinsights Publishing, United Kingdom
2023/03/01 - 2023/03/01
Concluded
Webinar on Optimize your mRNA process from pDNA template to LNP encapsulation (CELL & GENE THERAPY INSIGHTS) (Outros)
Bioinsights Publishing, United Kingdom
2020/06/18 - 2020/06/18
Concluded
X-omics workshop: data standards and multi-omics data integration (Outros)
X-omics Organization, Netherlands
2020/06/10 - 2020/06/10
Concluded
Workshop: "QIAGEN miRNA solutions" (Outros)
QIAGEN LLC, United States
2019/06/12 - 2019/06/12
Concluded
Workshop: "Everything you need to know about miRNA qPCR" (Outros)
QIAGEN LLC, United States
2013/02/01 - 2018/07/04
Concluded
Investigating the role of the Let-7 microRNA in Machado-Joseph disease (Pós-doutoramento)
Major in Neurosciences
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
N/A
2015/07/16 - 2015/07/16
Concluded
Workshop: Bioestatística para trabalhos de investigação (Outros)
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2015/02/05 - 2015/02/06
Concluded
Neuroepigenetics Advanced course of BEB PhD programme (Outros)
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2014 - 2014
Concluded
Course in laboratory animal science- category B + Certificate of Researcher-coordinator for the practice of animal experimentation (Outros)
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal

Direcção-Geral de Alimentação e Veterinária, Portugal
2013/01/15 - 2013/01/17
Concluded
Workshops at the Biogenesis and turnover of small RNAs meeting from Biochemical Society, Advancing Molecular Bioscience (Outros)
Biochemical Society, United Kingdom

Royal Society of Edinburgh, United Kingdom
2008/03/01 - 2012/07/24
Concluded
PhD in Biochemistry (Doutoramento)
Major in Biochemical Technology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"On the development of antitumoural therapeutic strategies: Suicide gene therapy mediated by lipid-based systems and cancer stem cell-based vaccination" (THESIS/DISSERTATION)
PhD with distinction and honors approved by unanim
2009/10 - 2010/07
Concluded
Advanced Communication Skills in English I and II (Outros)
Universidade de Coimbra Faculdade de Letras, Portugal
2010/04 - 2010/06
Concluded
Curso de Formação Inicial de Formadores to acquire the CAP certificate (106 h) (Outros)
Tecla Center, Portugal
2010/03/04 - 2010/03/05
Concluded
Workshop: "RNA Therapeutics" (Outros)
Harvard Medical School, United States

Fundação Calouste Gulbenkian, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
2009/09/03 - 2009/09/04
Concluded
GTRV- Summer School « Targeted Drug Delivery » (Outros)
École Polytechnique Fédérale de Lausanne, Switzerland
2005/02/22 - 2005/02/25
Concluded
Advanced Course on Gene Therapy (Outros)
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2000/09 - 2004/07/23
Concluded
Biochemistry (Licenciatura)
Major in Biochemistry
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Validação de uma técnica de HPLC para determinação de anti-inflamatórios do grupo do Etofenamato" (THESIS/DISSERTATION)
Final grade of 16 (out of 20).
Affiliation

Science

Category
Host institution
Employer
2023/09/01 - Current Auxiliary Researcher (Research) Universidade de Coimbra, Portugal
Center for Neurosciences and Cell Biology, Portugal
(...)
2019/02/01 - 2023/08/31 Contracted Researcher (Research) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2018/07/05 - 2019/01/31 Contracted Researcher (Research) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2013/02/01 - 2018/07/04 Postdoc (Research) Foundation for Science and Technology (Lisbon, Portugal) , Portugal
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2012/06/01 - 2012/12/31 Postdoc (Research) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2008/03/01 - 2012/07/24 Researcher (Research) Foundation for Science and Technology (Lisbon, Portugal) , Portugal
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2011/05/01 - 2011/08/05 Visiting Researcher (Research) Foundation for Science and Technology (Lisbon, Portugal) , Portugal
Centre National de la Recherche Scientifique (UMR 6235 CNRS), France
2010/09/06 - 2010/12/20 Visiting Researcher (Research) Foundation for Science and Technology (Lisbon, Portugal) , Portugal
Centre National de la Recherche Scientifique (UMR 6235 CNRS), France
2007/06/01 - 2008/02/29 Researcher (Research) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2005/01/01 - 2007/05/31 Researcher (Research) Universidade do Minho, Portugal
Universidade do Minho, Portugal
2003/09/01 - 2004/07/31 Research Trainee (Research) Laboratorios Basi S.A.-Industria Farmaceutica, Portugal
Laboratorios Basi S.A.-Industria Farmaceutica, Portugal

Others

Category
Host institution
Employer
2023/04/05 - 2023/09/01 CAREER BREAK: Maternity Leave: Coimbra, Portugal Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2014/07/01 - 2015/01/01 CAREER BREAK: Pregnancy/Maternity Leave: Coimbra, Portugal Foundation for Science and Technology (Lisbon, Portugal) , Portugal
Center for Neurosciences and Cell Biology, Portugal
Projects

Grant

Designation Funders
2023/03/01 - Current Pre-clinical evaluation of the brain-targeting AAV-PHP.eB encoding cholesterol hydroxylase CYP46A1 as a therapeutic strategy for spinocerebellar ataxia type 3 - towards the understanding of the neuroprotective mechanism
2022.04788.PTDC
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2023/01/01 - Current Direct Conversion of Astrocytes into Cerebellar Neurons as an Innovative Treatment for Spinocerebellar Ataxia Type-3
2022.06127.PTDC
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/09/01 - 2024/02/28 MicroRNA-specific small molecule modifiers as a new and promising therapeutic approach for Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3)
NAF Young Investigator Award
Principal investigator
Center for Neurosciences and Cell Biology, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
National Ataxia Foundation
Ongoing
2021/09/16 - 2024 "Repurposing FDA-approved Drugs as microRNA-specific modifiers towards a new and promising therapeutic approach for Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3)"
Trampoline Grant 23755
Principal investigator
Center for Neurosciences and Cell Biology, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
AFM-Téléthon
Ongoing
2018/07/06 - 2022/04/05 Role of microRNA deregulation in Machado-Joseph Disease: On the development of a microRNA-based therapeutic strategy
POCI-01-0145-FEDER-032309
Principal investigator
Center for Neurosciences and Cell Biology, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Fundação para a Ciência e a Tecnologia

Comissão de Coordenação e Desenvolvimento Regional do Centro
Ongoing
2020 - 2022/02/28 Intravenous delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of spinocerebellar ataxia type 3: a promising non-invasive therapeutic strategy
686213
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
National Ataxia Foundation
2019 - 2021/12 Gene Therapy for Cerebellar Ataxias: restoring cholesterol metabolism by targeting brain cholesterol 24 hydroxylase (CYP46A1) - SCA-CYP (International Consortium)
E-Rare-3 JTC 2017 (International Consortium)
Researcher
CNC.IBILI, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2018/06 - 2021/06 The impact of induced pluripotent stem cells-derived neuroepithelial stem cells transplantation in Machado-Joseph disease
POCI-01-0145-FEDER-030737
Researcher
Center for Neurosciences and Cell Biology, Portugal
Comissão de Coordenação e Desenvolvimento Regional do Centro

Fundação para a Ciência e a Tecnologia
Ongoing
2017/01 - 2020/12 BRAIN HEALTH 2020-Detecção Precoce,Neuro-modulação e TerapiasAvançadas para Neuropatologias
CENTRO-01-0145-FEDER-000008
Researcher
Center for Neurosciences and Cell Biology, Portugal
Centro2020 - Programa Operacional Centro 2020 (FEDER/FSE)

Foundation for Science and Technology (Lisbon, Portugal)
Ongoing
2016/04 - 2020/05 ModelPolyQ: Advanced models of polyglutamine disorders (HD, SCA3 and SCA7)
Researcher
Center for Neurosciences and Cell Biology, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
EU Joint Programme Neurodegenerative Disease Research
2016 - 2020/05 JPND European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative
JPCOFUND/0001/2015-ESMI (International Consortium)
Researcher
Center for Neurosciences and Cell Biology, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
EU Joint Programme Neurodegenerative Disease Research
Ongoing
2017/03/27 - 2020/03/26 LifeSciences ByCENTRO
CENTRO-01-0246-FEDER-000011
Researcher
CNC.IBILI, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Centro2020 - Programa Operacional Centro 2020 (FEDER/FSE)
2016/04 - 2019/03 Gene repair and repression strategies to alleviate Machado-Joseph disease
PTDC/NEU-NMC/0084/2014
Researcher
Center for Neurosciences and Cell Biology, Portugal
Foundation for Science and Technology (Lisbon, Portugal)
Concluded
2015/03 - 2018/12 Roles and mechanisms of synuclein and ataxin-3 spreading in Parkinson and Machado-Joseph diseases
JPND SynSpread: CD/0001/2013 (International consortium)
Researcher
Center for Neurosciences and Cell Biology, Portugal
EU Joint Programme Neurodegenerative Disease Research

Foundation for Science and Technology (Lisbon, Portugal)
Concluded
2013/02/01 - 2018/07/04 Investigating the role of the Let-7 microRNA in Machado-Joseph disease
SFRH/BPD/87552/2012
Post-doc Fellow
Center for Neurosciences and Cell Biology, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/03 - 2016/02 Machado-Joseph-Disease, protein aggregation, protein degradation, stem cell biology, proteostasis, neurodegeneration
E-Rare4/0003/2012 (International consortium)
Researcher
Center for Neurosciences and Cell Biology, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/03 - 2015/08 Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease
PTDC/BIM-MEC/0651/2012
Researcher
Center for Neurosciences and Cell Biology, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/03 - 2015/06 Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid-based nanosystem for systemic delivery
PTDC/DTP-FTO/0265/2012
Researcher
Center for Neurosciences and Cell Biology, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/06 - 2012/12 Non-invasive Non-viral Silencing of Machado-Joseph disease
PTDC/SAU-FAR/116535/2010
Research Fellow
Center for Neurosciences and Cell Biology, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/03/01 - 2012/03/01 ON THE DEVELOPMENT OF ANTITUMOURAL THERAPEUTIC STRATEGIES: Suicide gene therapy mediated by lipid-based systems and cancer stem cell-based vaccination
SFRH/BD/32797/2007
PhD Student Fellow
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Center for Neurosciences and Cell Biology, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/06 - 2008/02 Development of a novel approach for anti-tumor therapy based on the S413-PV cell penetrating peptide to improve the intracellular delivery of therapeutic proteins and nucleic acids
PTDC/BIO/65627/2006
Research Fellow
Center for Neurosciences and Cell Biology, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/01 - 2007/05 Preparação de agentes para Terapia Molecular por purificação e condensação simultânea de plasmídeos em sistemas de duas fases aquosas
POCTI BIO/47245/2002
Research Fellow
Universidade do Minho, Portugal
Universidade do Minho
Concluded

Contract

Designation Funders
2023/09/01 - Current CinTech - Technological Hub for Innovation, Translation and Industrialization of Complex Injectable Drugs
12345
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2020/07 - Current "miRSilencing" project
international collaborative project between the Center for Neuroscience and Cell Biology (CNC, UC, Portugal) and PTC Therapeutics (USA)
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
PTC Therapeutics Inc
Ongoing
2018/05 - Current "Targeting mutant ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using allele-specific ASOs
International collaborative project between CNC and Wave Life Sciences USA, Inc
Researcher
Center for Neurosciences and Cell Biology, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Wave Life Sciences USA, Inc
Ongoing
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Center for Innovative Biomedicine and Biotechnology
UIDB/04539/2020
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2019/02 - 2019/10 Targeting ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using AAV5 and an artificial microRNA
International Collaborative Project between CNC and uniQure Company
Researcher
Center for Neurosciences and Cell Biology, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
uniQure NV
Concluded
2015/01 - 2017/12 “CNC. IBILI”
UID/NEU/04539/2013
Researcher
Center for Neurosciences and Cell Biology, Portugal
Foundation for Science and Technology (Lisbon, Portugal)
Concluded

Other

Designation Funders
2022 - Current greenLabsCIBB (gLCIBB)
gLCIBB
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Ongoing
2018/05/01 - Current Collaboration with Wave Life Sciences company, uniQure and Brainvectis in the development of a gene therapy product applied to neurodegenerative disorders, particularly to polyglutamine disorders.
INTERNATIONAL NETWORKS
Researcher
Center for Neurosciences and Cell Biology, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Ongoing
2018 - Current Lab management (organizing/ordering/managing the lab products, space/people in the lab)
LAB MANAGMENT
Other
Center for Neurosciences and Cell Biology, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Ongoing
2013 - Current Collaboration with La Spada AR, who first discovered polyglutamine disorders at the University of Duke
INTERNATIONAL NETWORK
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Ongoing
Outputs

Publications

Book chapter
  1. Nóbrega, Clévio; Simões, Ana Teresa; Duarte-Neves, Joana; Duarte, Sónia; Vasconcelos-Ferreira, Ana; Cunha-Santos, Janete; Pereira, Dina; et al. "Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis". In Polyglutamine Disorders in Advances in Experimental Medicine and Biology, 349-367. Springer International Publishing, 2018.
    Published • 10.1007/978-3-319-71779-1_18
  2. Cardoso, Ana Luísa; Trabulo, Sara; Duarte, Sónia; Costa, Pedro M; Pereira de Almeida, Luis; Pedroso De Lima, M.C.. "Gene silencing as a promising strategy to target CNS and neurological disorders". In Gene Silencing: Theory, Techniques and Applications, 81-110. Nova Science Publishers, 2013.
    Published
  3. Faneca, Henrique; Cardoso, Ana Luísa; Trabulo, Sara; Duarte, Sónia; de Lima, Maria C. Pedroso. "Cationic Liposome-Based Systems for Nucleic Acid Delivery: From the Formulation Development to Therapeutic Applications". In Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment, 153-184. Springer Netherlands, 2013.
    10.1007/978-94-007-6010-3_6
Conference abstract
  1. C Henriques, M Lopes, P Albuquerque, D Rufino?Ramos, L Gaspar, D Lobo, A C Silva, R Baganha, S Duarte; C Maguire, M Santana, L Pereira de Almeida, R J Nobre. "P087 Production and isolation of natural and biologically active exo-AAvs for brain gene delivery". Paper presented in ESGCT 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11–14, Edinburgh, 2022.
    Published • http://doi.org/10.1089/hum.2022.29225.abstracts
  2. A C Silva, D D Lobo, C Henriques, I M Martins, S M Lopes, S P Duarte; E Wagner, R J Nobre, L Pereira de Almeida. "P214 Silencing of mutant ATXN3 through antisense oligonucleotides rescues molecular and neuropathological features in Machado-Joseph disease mice". Paper presented in European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, Edinburgh, 2022.
    Published • http://doi.org/10.1089/hum.2022.29225.abstracts
  3. B Serra, S P Duarte, N Cartier, S Alves, L P de Almeida, R Perfeito. "P221 Systemic delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of Machado-Joseph disease: a promising therapeutic strategy". Paper presented in European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, Edinburgh, 2022.
    Published • http://doi.org/10.1089/hum.2022.29225.abstracts
  4. Carlos A. Matos; Frederico Pena; Andre Conceicao; Sara Lopes; Sónia Duarte; et al.. "CRISPR-Cas9-Mediated Pre-Transcriptional Silencing of Mutant ATXN3 Decreases Motor Impairments of an In Vivo Machado-Joseph Disease Model. MOLECULAR THERAPY (2019) 27 (4): 120-121". Paper presented in 22nd Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT), Washington, DC, USA, 2019, 2019.
    Published
  5. Catarina Oliveira Miranda; Adriana Marcelo; Teresa Pereira Silva; Joao Barata; Ana Vasconcelos-Ferreira; Dina Pereira; Sónia Duarte; et al.. "Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy, In European Journal of Clinical Investigation (2019) 49 (S1): 44-44". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), May 22-24, 2019, Coimbra, Portugal., 2019.
    Published • 10.1111/eci.13109
  6. C Matos; F Pena; A Conceicao; Lopes S.; Duarte, S.P; et al.. "CRISPR interference-mediated silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model, In European Journal of Clinical Investigation (2019) 49 (S1): 86-87". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), May 22-24, 2019, Coimbra, Portugal., 2019.
    Published • 10.1111/eci.13109
  7. Duarte, Sónia; Beatriz Estremores; Janete Cunha-Santos; Miranda, Catarina; João Barata; AR La Spada; Pereira de Almeida, Luis. "Let-7 microRNA overexpression mediated by lentivirus alleviates neuropathology, balance and motor deficits in Machado-Joseph disease mouse models, HUMAN GENE THERAPY (2018) 29 (12), A81-A81". Paper presented in 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland, 2018.
    Published • 10.1089/hum.2018.29077.abstracts
  8. CO Miranda; A Marcelo; TP Silva; J Barata; A Vasconcelos-Ferreira; D Pereira; S Duarte; et al.. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease/spinocerebellar ataxia type-3, HUMAN GENE THERAPY (2018) 29 (12), A56-A56". Paper presented in 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland, 2018.
    Published • 10.1089/hum.2018.29077.abstracts
  9. L Mendonça; D Henriques; R Moreira; Sónia Duarte; JC Schwamborn; L Pereira de Almeida. "Generation and transplantation of patient-specific iPSC-derived neuroepithelial stem cells for Machado-Joseph disease treatment, HUMAN GENE THERAPY (2018) 29 (12), A66-A66". Paper presented in 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland, 2018.
    Published • 10.1089/hum.2018.29077.abstracts
  10. Duarte, S.; de Almeida LP; La Spada, A.R.. "Unravelling let-7 role in Machado-Joseph Disease, In Human Gene Therapy (2016) 27 (11), A1-A185". Paper presented in XXIVth Annual Congress of European Society of Gene and cell Therapy, October 18-21, 2016, Florence, Italy, 2016.
    Published • 10.1089/hum.2016.29035.abstracts
  11. Duarte, S.; Faneca, H.; Pedroso de Lima, M.C.. "Development of folate-lipid-based systems for tumour-targeted gene delivery, In Ejc Supplements (2010) 8 (5): 72-72". Paper presented in 21st Meeting of the European Association for Cancer Research, June 26-29, 2010, Oslo, Norway., 2010.
    Published • 10.1016/s1359-6349(10)71079-x
  12. Trabulo, S.; Mano, M; Faneca, H.; Cardoso, A.L.; Duarte, S.; Gomes, P.; Simões, S.; Pedroso De Lima, M.C.. "Association of S4 (13)-PV cell penetrating peptide with cationic liposomes: A synergistic effect on the intracellular delivery of plasmid DNA, In Journal of Peptide Science (2008) 14 (8), 135-135". Paper presented in 30th European Peptide Symposium (30EPS), August 31-September 5, 2008, Helsinki, Finland, 2008.
    Published • 10.1002/psc.1090
  13. Duarte, S.; Faneca, H.; Trabulo, S.; Cardoso, A.L.; Pedroso de Lima, M.C.. "Folate-associated cationic liposomes as a promising system for tumor-targeted gene delivery, Human Gene Therapy (2008) 19 (10): 1153". Paper presented in XVIth European Society of Gene and Cell Therapy Meeting, November 12-16, 2008, Bruges, Belgium, 2008.
    Published • 10.1089/hum.2008.1034
  14. Duarte, Sónia; Fortes, António G.; Prazeres, Duarte. M.; Marcos, João C.. "Integration of plasmid DNA purification and molecular therapy agent preparation using aqueous two-phase systems, In Journal of Biotechnology (2007) 131 (2): S6". Paper presented in 13th European Congress on Biotechnology, September 16-19, 2007, Barcelona, Spain, 2007.
    Published • 10.1016/j.jbiotec.2007.07.012
Conference poster
  1. A C Silva, C Henriques, D D Lobo, A R Fernandes, M Lopes, D Pereira,; S P Duarte, R Baganha, S M Lopes, M Santana, R J Nobre L Pereira de Almeida. "Allele-specific silencing of mutant ATXN3 rescues motordeficits and neuropathology in a severely impaired mouse model of spinocerebellar ataxia type 3 (SCA3) upon intra-cisterna magna administration". Paper presented in 30th ESGCT meeting, 24th-27th October 2023, 2023.
  2. Silva, Patrick; Santana, Magda M; Pinto, Maria; Gaspar, Laetitia S; Nobre, Rui Jorge; Duarte, Sónia; Monteiro Marques, Tania; et al. "Discrimitating spinocerebellar ataxia type 3 ataxic mutation carriers from control and pre-ataxic throuh miRNA expression profiles in plasma-derived extracellular vesicles". Paper presented in EMBO|EMBL Symposium: The non-coding genome, 2023.
  3. Silva, Ana Carolina; Henriques, Carina; Lobo, Diana Duarte; Pereira, Dina; Duarte, Sónia; Lopes, Sara Monteiro; Lopes, Miguel Monteiro; et al. "Investigating routes of administration and AAV serotypes for development of a gene-based therapy for spinocerebellar ataxia type 3 (SCA3)". Paper presented in ESGCT 30th Congress, 2023.
  4. Santos, Bárbara; Afonso, Mariana; Alves, André; Amaral, Sandra; Candeias, Emanuel,; Cardoso, Maria; Cortes, Luísa; Cruz, Teresa; Da Silva, Jéssica; Duarte, Sónia P., et al.. "GreenLabsCIBB - One path for sustainable research". Paper presented in Green Labs Portugal Symposium: Promoting sustainability in Research, 2023.
  5. Mendes, Cândida; Marques, Carla; Mota, Sandra I.; Afonso, Mariana; Alves, André; Amaral, Sandra; Candeias, Emanuel; Cardoso, Maria; Cortes, Luísa; Cruz, Teresa; Da Silva, Jéssica; Duarte, Sónia P. et al.. ""Collection Points"-Reuse and Recycling". Paper presented in Green Labs Portugal Symposium: Promoting sustainability in Research, 2023.
  6. Alarico, S., Afonso M., Alves A., Amaral S., Amorim R., Candeias E., Cardoso M., Cortes L., Cruz T., Duarte S.P., Faria ; Gonçalves M., Lavoura N., Léger H., Manadas B., Marques C., Marques C.I., Mele M., Mendes C., Miranda C., Mota S.I., Rib; Romera L., Roxo I. , Santos B., Santiago A.R., Santos D., Sebastião A.I., Simões I.. "GreenLabsCiBB | One path for sustainable research". Paper presented in Envisioning the research centres of the future | EU-LIFE, June 2023, Gulbenkian, 2023.
  7. Carina Henriques, Miguel Lopes, Patricia Albuquerque, David Rufino-Ramos, Laetitia Gaspar, Diana Lobo, Ana Carolina Silv; Sónia Duarte, Casey A. Maguire, Magda Santana, Luis Pereira de Almeida*, Rui Jorge Nobre*. "ISOLATION OF NATURAL AND BIOLOGICALLY ACTIVE EV-AAVs FOR BRAIN GENE DELIVERY". Paper presented in American Society of Gene & Cell Therapy (ASGCT), 26th Annual Meeting, May 16-20, 2023 | Los Angeles, CA, 2023.
  8. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Martins, Inês; Duarte, Sónia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Miranda, Catarina. Corresponding author: Miranda, Catarina. "Mesenchymal Stromal Cell Therapeutic Potential to Restore Blood-Brain Barrier Integrity in Machado-Joseph Disease". Paper presented in FENS Regional Meeting 2023 (FRM), 2023.
  9. Serra, Beatriz; Duarte, Sónia; Françoise, PIGUET; Nathalie Cartier; Alves, Sandro; de Almeida, Luis Pereira; Perfeito, Rita. "Validation of the brain-targeting AAV- PHP.eB encoding cholesterol hydroxylase CYP46A1: a promising non-invasive therapeutic strategy for Spinocerebellar Ataxia Type 3". Paper presented in FENS Regional Meeting 2023, 2023.
  10. Beatriz Guedes, Sónia Duarte, Sandra Morais Cardoso, Ana Raquel Esteves. "Unmasking miRNA 486-5p role in Parkinson's disease: inflammation in the spotlight". Paper presented in AD/PD 2023 International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders. 28 March-1 April, Gothenburg, Sweden., 2023.
  11. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Nobre, Rui Jorge; Martins, Inês; Silva, António; Duarte, Sónia; Pereira de Almeida, L; Miranda, Catarina Oliveira. "Altered Tight Junction-Associated Proteins Subcellular Localization in Machado-Joseph Disease/Spinocerebellar Ataxia Type 3.". Paper presented in 26ª Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH), 2022.
  12. D Santos, MI Santos, R Baganha, RJ Nobre, M Figiel, ; L Pereira de Almeida, ; and SP Duarte. Corresponding author: and SP Duarte. "P231 MicroRNAs as cornerstones in Machado-Joseph disease pathogenesis: Development of a microRNA-based gene therapy". Paper presented in European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, 2022.
  13. C Henriques, M Lopes, P Albuquerque, D Rufino-Ramos, L Gaspar, D Lobo, A C Silva, ; R Baganha, S Duarte, C Maguire, M Santana, L Pereira de Almeida, R J Nobre. "P087 Production and isolation of natural and biologically active exo-AAvs for brain gene delivery". Paper presented in European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, 2022.
  14. A C Silva, D D Lobo, C Henriques, I M Martins, S M Lopes, S P Duarte,; E Wagner, R J Nobre, L Pereira de Almeida. "P214 Silencing of mutant ATXN3 through antisense oligonucleotides rescues molecular and neuropathological features in Machado-Joseph disease mice". Paper presented in European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, 2022.
  15. B Serra, S P Duarte, N Cartier, S Alves, L P de Almeida, R Perfeito. "P221 Systemic delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of Machado-Joseph disease: a promising therapeutic strategy". Paper presented in European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, 2022.
  16. Diana Santos, Maria Inês Santos, Rafael Baganha, Rui Jorge Nobre; Maciej Figiel, Luís Pereira de Almeida; Sónia Patrícia Duarte (Presenter). Corresponding author: Sónia Patrícia Duarte (Presenter). "Investigating microRNA dysregulation towards the development of a microRNA-based therapy for Spinocerebellar ataxia type-3|Machado-Joseph disease (SCA3|MJD)". Paper presented in CONGRESSO SPDMOV (Sociedade Portuguesa das Doenças do Movimento) 2022, April 1, 2, 2022.
  17. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Martins, Inês; Silva, António; Duarte, Sónia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Miranda, Catarina Oliveira. Corresponding author: Miranda, Catarina Oliveira. "Unravelling Mesenchymal Stromal Cells Potential for Alleviation of Blood-Brain Barrier Disruption in Machado-Joseph Disease". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022.
  18. Maria Inês Barros, António da Silva, Inês Martins, Sónia Duarte, Rui Jorge Nobre, Ana Teresa Simões, ; Luís Pereira de Almeida* and Catarina Oliveira Miranda*. "Therapeutic effects of Mesenchymal Stromal Cells Secretome in Machado-Joseph Disease Models". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021.
  19. Sandra O. Braz, Catarina Vinhas, Daniel Henriques, Ricardo Moreira, Rosário Faro, Sónia Duarte, ; Luis Pereira de Almeida and Liliana S. Mendonça. "Cerebellar transplantation of iPSC-derived neuroepithelial stem cells silenced for mutant ATXN3 for Machado-Joseph disease". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021.
  20. Diana Santos, Maria Inês Santos, Rafael Baganha, Rui Jorge Nobre, Luis Pereira de Almeida* ; Sónia P. Duarte*. Corresponding author: Sónia P. Duarte*. "Restoration of dysregulated microRNA levels in a transgenic mouse model of Machado-Joseph disease as a novel therapeutic approach". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021.
  21. Maria Inês Santos, Ana Daniela Oliveira, Maria M. Pinto, Magda M. Santana, Diana Santos, Ana Rita Álvaro,; Luís Pereira de Almeida* ; Sónia P. Duarte*. Corresponding author: Sónia P. Duarte*. "miRNA dysregulation in Machado-Joseph disease: what can we learn from human induced pluripotent stem cell-based models?". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021.
  22. Beatriz Serra; Sónia P. Duarte; Nathalie Cartier; Sandro Alves; Luís Pereira de Almeida; Rita Perfeito. "Intravenous delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of spinocerebellar ataxia type 3: a promising non- invasive therapeutic strategy". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021.
  23. Ana Carolina Silva, Diana D. Lobo, Carina Henriques, Inês M. Martins, Sara M. Lopes, Sónia P. Duarte, Elizabeth Wagner,; Rui Jorge Nobre* and Lui´s Pereira de Almeida*; *Equal contribution. "Antisense oligonucleotide mediated allele-specific silencing of mutant ATXN3 improves disease features in mouse models of Machado-Joseph disease". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021.
  24. Silva, Ana Carolina; Lobo, Diana Duarte; Henriques, Carina; Martins, Maria Inês; Lopes, Sara Monteiro; Duarte, Sónia Patrícia; Wagner, E; Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. "Allele-specific silencing of Machado-Joseph disease using antisense oligonucleotide therapeutics". Paper presented in 1st Symposium on Oligonucleotide Technologies and Therapeutics@Portugal, 2021.
  25. Sónia Patrícia Duarte, Beatriz Estremores, Janete Cunha-Santos, Catarina Oliveira Miranda, João Barata, Diana Santos,; Maciej Figiel, Albert La Spada, Luis Pereira de Almeida. "MicroRNA profiling in Spinocerebellar ataxia type-3: On the development of a miRNA-based therapy". Paper presented in NAF's biennial Ataxia Investigators Meeting (AIM 2020)---Postponed to May 24-27, 2021, virtual AIM due to COVID pandemics, 2021.
  26. Mendonça Liliana; Daniel Henriques; Vanessa Fernandes; Ricardo Moreira; Ana C. Vinhas; Rosário Faro; Sónia Duarte; et al.. ""Patient specific IPSC-derived neuroepithelial stem cells for cell-based therapy in Machado-Joseph disease"". Paper presented in FENS 2020 Virtual Forum (accepted for electronic poster presentation), July 11-15, 2020, 2020.
  27. Lodewilk Toonen, Raygene Martier, Rui Nobre, Astrid Valles, Janice Stricker-Shaver,; Jeannette Hübener-Schmid, Sonia Duarte, et al.. "Assessment of the Novel AAV-Based miQURE Gene Therapy in SCA3 Animal Models". Paper presented in ASGCT 23rd Annual meeting, 2020.
  28. Henriques C; Lopes, M; Albuquerque PR; Rufino-Ramos D; Gaspar L; Lobo D; Duarte S; et al. "Extracellular vesicles-associated AAVs as new gene delivery vectors for the treatment of brain disorders". Paper presented in 3rd BEB Day (2019), 2019.
  29. Barros MI; Martins Inês; Duarte, S.P.; Nobre RJ; Simões AT; Miranda CO; Pereira de Almeida L. "Assessing the putative role of mesenchymal stromal cells effectors in Machado-Joseph disease". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences (Coimbra, Portugal), 2019, 2019.
  30. Ricardo Moreira; Liliana S. Mendonça; Daniel Henriques; Sónia Duarte; et al.. ""Investigation of Mutant Ataxin-3 spreading in Machado-Joseph Disease"". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences (Coimbra, Portugal), 2019, 2019.
  31. Henriques C; Lopes, M; Albuquerque PR; Rufino-Ramos D; Gaspar L; Lobo D; Duarte S; et al. "Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases". Paper presented in 5th GEIVEX Symposium, November 6-8, 2019, 2019.
  32. Carlos A. Matos; André Conceição; Frederico Pena; Sara Lopes; Duarte, Sónia; Catarina Miranda; Luis Pereira de Almeida. "TRANSCRIPTIONAL REPRESSION OF MUTANT HUMAN ATNX3 USING CRISPR INTERFERENCE MITIGATES THE PATHOLOGICAL PHENOTYPE OF AN IN VIVO MACHADO-JOSEPH DISEASE MODEL". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), May 30-June 1, 2019, Lisbon, Portugal., 2019.
  33. Liliana S. Mendonça; Ricardo Moreira; Daniel Henriques; Duarte, Sónia; Teresa Rodrigues; Henrique Girão; Jens C. Schwamborn; Luis Pereira de Almeida. "INVESTIGATION OF MUTANT ATAXIN-3 SPREADING IN MACHADO-JOSEPH DISEASE". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), May 30-June 1, 2019, Lisbon, Portugal., 2019.
  34. Catarina Oliveira Miranda; Adriana Marcelo; Teresa P. Silva; Joao Barata; Ana Vasconcelos-Ferreira; Dina Pereira; Duarte S; et al.. "Sustainable phenotypic ameliorations in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells and can be monitored through proton Magnetic Resonance Spectroscopy biomarkers". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), May 30-June 1, 2019, Lisbon, Portugal., 2019.
  35. Sónia Patrícia Duarte, Beatriz Estremores, Janete Cunha-Santos, Catarina Miranda, João Barata, Albert La Spada, ; Luis Pereira de Almeida. "Upregulation of let-7 microrna in mouse models of Machado-Joseph disease ameliorates neuropathology and motor phenotype". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), May 22-24, 2019, Coimbra, Portugal., 2019.
  36. Miranda CO; Adriana Machado; Silva Teresa P; Barata, J.; Vasconcelos-Ferreira A; Pereira, Dina; Duarte S; et al.. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease and Its Efficacy Can Be Monitored With Neurospectroscopic Biomarkers". Paper presented in 1st international symposium Secretome With]Out[ Borders, December 6 - 7th, 2018, 2018.
  37. Duarte, Sónia; B Estremores, J Cunha-Santos, C O Miranda, J Barata, A R La Spada, L P de Almeida. "Let-7 microRNA overexpression mediated by lentivirus alleviates neuropathology, balance and motor deficits in Machado-joseph disease mouse models". Paper presented in 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland., 2018.
  38. Miranda CO, Machado A, Silva T, Barata J, Vasconcelos-Ferreira A, Pereira D, Duarte S, Nóbrega C; Sereno J, Peretrella L, Paiva V, Castelhano J, Nobre R, Gomes C, Castelo-Branco M and de Almeida LP. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3". Paper presented in 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland., 2018.
  39. L Mendonça, D Henriques, R Moreira, S Duarte, JC Schwamborn and L Pereira de Almeida. "Generation and transplantation of patient-specific iPSC-derived neuroepithelial stem cells for Machado-Joseph disease treatment". Paper presented in 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland., 2018.
  40. Miranda C.O., Machado A., Silva T., Barata J., Pereira D., Vasconcelos-Ferreira A., Nóbrega C., Peretrella L.; Sereno J., Castelhano J., Duarte S., Nobre R., Paiva V., Castelo-Branco M. and de Almeida L.P.. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3 through neuroprotection of GABAergic neurons". Paper presented in 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), October 12-14, 2017, Covilhã, Portugal., 2017.
  41. Duarte, Sónia; Miranda, C.O., Cunha-Santos, J., Barata, J., Estremores, B., La Spada, A.R., de Almeida, L.P.. "Let-7 activates autophagy and alleviates motor and neuropathological deficits in pre- and post-symptomatic Machado-Joseph disease mouse models". Paper presented in International Ataxia Research Conference, September 27-30, 2017, Pisa, Italy., 2017.
  42. Miranda C.O., Machado A., Silva T., Barata J., Nóbrega C., Duarte S.; Nobre R., Sereno J., Paiva V., Castelhano J., Castelo-Branco M. and de Almeida L.P. "Repeated systemic injection of mesenchymal stem cells sustainably alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease". Paper presented in XV Meeting of the Portuguese Society for Neuroscience, May 25-26, 2017, Braga, Portugal., 2017.
  43. Duarte, Sónia; Catarina Oliveira Miranda, Janete Cunha-Santos, João Barata, Albert R. La Spada, Luís Pereira de Almeida. "Autophagy activation mediated by let-7 alleviates motor and neuropathological deficits in pre- and post-symptomatic Machado-Joseph disease mouse models". Paper presented in XV Meeting of the Portuguese Society for Neuroscience, May 25-26, 2017, Braga, Portugal., 2017.
  44. Duarte, Sónia; La Spada A.R., de Almeida L.P.. "Unravelling let-7 role in Machado-Joseph Disease". Paper presented in XXIVth Annual Congress of European Society of Gene and cell Therapy, October 18-21, 2016, Florence, Italy, 2016.
  45. Magda M Santana; Nóbrega, Clévio David Rodrigues ; Nobre, Rui Jorge; Miranda, Catarina; Sousa-Ferreira, Ligia; Simões, Ana Teresa; Duarte, Sónia; et al. "Gene therapy approaches to investigate pathogenesis and disease modifying strategies for neurodegenerative diseases". Paper presented in Showcasing Portuguese Pharma Science:Advances in Discovery, Development and Manufacturing. Hovione and MIT Portugal Pharma Science Symposium, 2014.
  46. Duarte, Sónia; Faneca H. and Pedroso de Lima M.C.. "A novel folate-associated lipoplex formulation for gene delivery: evaluation of the potential for HSV-tk/valganciclovir suicide gene therapy in vitro and in vivo". Paper presented in XX Porto cancer meeting, April 28-29, 2011, Porto, Portugal., 2011.
  47. Duarte, Sónia; Faneca H. and Pedroso de Lima M.C.. "Development of folate-lipid-based systems for tumor-targeted gene delivery". Paper presented in 21st Meeting of the European Association for Cancer Research, June 26-29, 2010, Oslo, Norway., 2010.
  48. Duarte, Sónia; Faneca H., Trabulo S., Cardoso A.L. and Pedroso de Lima M.C.. "Folate-associated cationic liposomes as a promising system for tumor-targeted gene delivery". Paper presented in XVIth European Society of Gene and Cell Therapy Meeting, November 12-16, 2008, Bruges, Belgium., 2008.
  49. Trabulo S., Mano M., Faneca H., Cardoso A.L., Duarte S., Gomes P., Simões S., de Lima M.C.. "Association of S413-PV cell penetrating peptide with cationic liposomes: a synergistic effect on the intracellular delivery of plasmid DNA". Paper presented in 30th European Peptide Symposium (30EPS), August 31-September 5, 2008, Helsinki, Finland., 2008.
  50. Trabulo S., Mano M., Faneca H., Cardoso A.L., Duarte S., Simões S., Pedroso de Lima M.C. "S4(13)-PV cell penetrating peptide-based systems for the intracellular delivery of plasmid DNS and siRNA". Paper presented in V Encontro anual do CNC, December 20-21, 2007, Coimbra, Portugal., 2007.
  51. Duarte S., Marcos J.C.. "Quantification of plasmid DNA in the presence of PEGylated polyethyleneimine by hydrophobic interaction chromatography". Paper presented in 5º Encontro Nacional de Cromatografia, December 10-12, 2007, Aveiro, 2007.
  52. Trabulo S., Mano M., Faneca H., Cardoso A.L., Duarte S., Simões S., de Lima M.C.. "Enhancement of the intracellular delivery of siRNA and plasmid DNA using S4(13)-PV cell penetrating peptide-based systems". Paper presented in 2nd Intracellular Delivery of Therapeutic Molecules – From Concept to Application, September 19-21, 2007, Grenoble, France., 2007.
  53. Duarte, Sónia; Fortes A.G., Prazeres D.M.F., Marcos J.C.. "Integration of plasmid DNA purification and molecular therapy agent preparation using aqueous two-phase systems". Paper presented in 13th European Congress on Biotechnology, September 16-19, 2007, Barcelona, Spain., 2007.
  54. Duarte, Sónia; Barbosa H., Prazeres D.M.F. and Marcos J.C.. "Isolation of DNA Plasmid from Polyethyleneimine Polyplexes in Aqueous Two-Phase Systems". Paper presented in International Conference on Biopartitioning and Purification (BPP 2005), June 20-24, 2005, Netherlands., 2005.
Journal article
  1. Mendonça, Liliana S.; Henriques, Daniel; Fernandes, Vanessa; Moreira, Ricardo; Brás, João; Duarte, Sónia; Schwamborn, Jens C.; de Almeida, Luís Pereira. "Graft-derived neurons and bystander effects are maintained for six months after human iPSC-derived NESC transplantation in mice’s cerebella". Scientific Reports 14 1 (2024): http://dx.doi.org/10.1038/s41598-024-53542-x.
    10.1038/s41598-024-53542-x
  2. D Santos, MI Santos, R Baganha, RJ Nobre, M Figiel; L Pereira de Almeida, S P Duarte. "MicroRNAs as cornerstones in Machado-Joseph disease pathogenesis: Development of a microRNA-based gene therapy". Human Gene Therapy 33 23-24 (2022): A1-A212. http://dx.doi.org/10.1089/hum.2022.29225.abstracts.
    Published • 10.1089/hum.2022.29225.abstracts
  3. Rui Jorge Nobre; Diana D. Lobo; Carina Henriques; Sonia P. Duarte; Sara M. Lopes; Ana C. Silva; Miguel M. Lopes; et al. "MiRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3". Nucleic Acid Therapeutics (2021): https://doi.org/10.1089/nat.2021.0020.
    10.1089/nat.2021.0020
  4. Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif et al.. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy (2021): https://www.tandfonline.com/doi/citedby/10.1080/15548627.2020.1797280?scroll=top&needAccess=true.
    Published • 10.1080/15548627.2020.1797280
  5. Silva, Ana C; Lobo, Diana D; Martins, Inês M; Lopes, Sara M; Henriques, Carina; Duarte, Sónia P; Dodart, Jean-Cosme; Nobre, Rui Jorge; Pereira de Almeida, Luis. "Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders". Brain 143 2 (2019): 407-429. http://dx.doi.org/10.1093/brain/awz328.
    Open access • Published • 10.1093/brain/awz328
  6. Sónia Patrícia Duarte; Beatriz Estremores; Janete Cunha-Santos; Catarina Miranda; João Barata; Albert La Spada; Luis Pereira de Almeida. "Upregulation of let-7 microrna in mouse models of Machado-Joseph disease ameliorates neuropathology and motor phenotype". European Journal of Clinical Investigation 49 S1 (2019): 101-221. http://dx.doi.org/10.1111/eci.13109.
    Published • 10.1111/eci.13109
  7. Duarte, Sónia; Estremores, Beatriz; Cunha-Santos, Janete; Miranda, Catarina; Barata, João; La Spada, Albert; De Almeida, Luis. "Autophagy activation induced by let-7 microRNA overexpression counteracts disease phenotype in Machado-Joseph disease mouse models". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/conf.fncel.2019.01.00026.
    Published • 10.3389/conf.fncel.2019.01.00026
  8. Oliveira Miranda, C.; Marcelo, A.; Silva, T.P.; Barata, J.; Vasconcelos-Ferreira, A.; Pereira, D.; Nóbrega, C.; et al. "Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease". Molecular Therapy 26 9 (2018): 2131-2151. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050950218&partnerID=MN8TOARS.
    Published • 10.1016/j.ymthe.2018.07.007
  9. Dubinsky, A.N.; Dastidar, S.G.; Hsu, C.L.; Zahra, R.; Djakovic, S.N.; Duarte, S.; Esau, C.C.; et al. "Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy". Cell Metabolism 20 4 (2014): 626-638. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907967415&partnerID=MN8TOARS.
    Published • 10.1016/j.cmet.2014.09.001
  10. Duarte, S.; Momier, D.; Baqué, P.; Casanova, V.; Loubat, A.; Samson, M.; Guigonis, J.-M.; et al. "Preventive cancer stem cell-based vaccination reduces liver metastasis development in a rat colon carcinoma syngeneic model". Stem Cells 31 3 (2013): 423-432. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874818661&partnerID=MN8TOARS.
    Published • 10.1002/stem.1292
  11. Duarte, S.; Carle, G.; Faneca, H.; Lima, M.C.P.D.; Pierrefite-Carle, V.. "Suicide gene therapy in cancer: Where do we stand now?". Cancer Letters 324 2 (2012): 160-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864392111&partnerID=MN8TOARS.
    Published • 10.1016/j.canlet.2012.05.023
  12. Duarte, S.; Loubat, A.; Momier, D.; Topi, M.; Faneca, H.; Pedroso De Lima, M.C.; Carle, G.F.; Pierrefite-Carle, V.. "Isolation of head and neck squamous carcinoma cancer stem-like cells in a syngeneic mouse model and analysis of hypoxia effect". Oncology Reports 28 3 (2012): 1057-1062. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865312688&partnerID=MN8TOARS.
    Published • 10.3892/or.2012.1904
  13. Duarte, S.; Faneca, H.; Lima, M.C.P.D.. "Folate-associated lipoplexes mediate efficient gene delivery and potent antitumoral activity in vitro and in vivo". International Journal of Pharmaceutics 423 2 (2012): 365-377. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856552664&partnerID=MN8TOARS.
    Published • 10.1016/j.ijpharm.2011.12.035
  14. Duarte, S.; Faneca, H.; Pedroso De Lima, M.C.. "Non-covalent association of folate to lipoplexes: A promising strategy to improve gene delivery in the presence of serum". Journal of Controlled Release 149 3 (2011): 264-272. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951941675&partnerID=MN8TOARS.
    Published • 10.1016/j.jconrel.2010.10.032
  15. Trabulo, Sara; Mano, Miguel; Faneca, Henrique; Cardoso, Ana Luísa; Duarte, Sónia; Henriques, Ana; Paiva, Artur; et al. "S413-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA". The Journal of Gene Medicine 10 11 (2008): 1210-1222. http://dx.doi.org/10.1002/jgm.1247.
    Published • 10.1002/jgm.1247
  16. Duarte, S.P.; Fortes, A.G.; Prazeres, D.M.F.; Marcos, J.C.. "Preparation of plasmid DNA polyplexes from alkaline lysates by a two-step aqueous two-phase extraction process". Journal of Chromatography A 1164 1-2 (2007): 105-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548030710&partnerID=MN8TOARS.
    Published • 10.1016/j.chroma.2007.06.061
Newspaper article
  1. Ana Catarina Vinhas; Ana Cristina Ferreira; Carina Henriques; Carolina Silva; et al.. "DOENÇAS RARAS: Uma viagem rara - Cartoon created on purpose for the Journal "THE PUBLIC" to explain a rare disease that affects many Portuguese, Machado-Joseph disease.", Público, 2020, https://www.publico.pt/2020/02/28/ciencia/fotogaleria/viagem-rara-400481.
Thesis / Dissertation
  1. Duarte, Sónia. "ON THE DEVELOPMENT OF ANTITUMOURAL THERAPEUTIC STRATEGIES: Suicide gene therapy mediated by lipid-based systems and cancer stem cell-based vaccination". PhD, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2012. http://hdl.handle.net/10316/20480.
  2. Duarte, Sónia. "Validação de uma técnica de HPLC para determinação de anti-inflamatórios do grupo do Etofenamato". Degree, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2004.

Artistic / Performance

Script
  1. Carolina Simões; Rita Perfeito; Sónia Duarte; João Cardoso; Luís Pereira de Almeida.. Vale a pena financiar a investigação em doenças raras? - Conteúdo Multimédia "A Saúde no Saber: Um Mito Animado - Episódio 7". https://www.facebook.com/watch/?v=592303805091989. 2021.
Video recording
  1. Sónia Duarte and Luis Ribeiro; Carolina Caetano (Producer); Carolina Caetano, Luisa carreira, Susana Alarico and Sara Amaral (Director). 2022. Video Reusing/Recycling "Collection points"_GreenLabsCIBB. Social Media networks, namely twitter.

Other

Other output
  1. MicroRNA profiling in human cell-based models of Machado-Joseph disease. 2020. Maria Inês Santos, Sónia Patrícia Duarte. http://hdl.handle.net/10316/92999.
  2. The role of autophagy activation-mediated by Let-7 in a transgenic mouse model of Machado-Joseph Disease. 2018. Estremores, Beatriz; Duarte, Sónia Patricia. http://hdl.handle.net/10316/86233.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/02/07 Targeted silencing via AAV9 polycistronic microRNA therapy rescues SCA3 molecular, neuropathological and motor deficits 54th Annual meeting of the Portuguese Pharmacology Society, Lisboa, 7-9 February 2024
NOVA Medical School
2024/02/07 Mesenchymal Stromal Cell Therapeutic Potential to Restore Neurovascular Integrity in Spinocerebellar Ataxia Type 3 54th Meeting of the Portuguese Society of Pharmacology, Lisboa, 7-9 February 2024
NOVA Medical School
2022/10/28 MicroRNAs at the cornerstone of Machado-Joseph Disease pathogenesis: Leveraging disease-associated miRNA dysregulation to develop microRNA-based therapeutics (by invitation) 4th meeting of the CIBB thematic area ‘Innovative Therapies’
Anfiteatro Subunidade 3 | FMUC, Polo III (Coimbra, Portugal)
2022/06/01 MicroRNA pathway dysfunction in Machado-Joseph disease: implications in pathology and development of a microRNA-based therapy (by Invitation) DCV.Talks
Amphitheatre 1, S. Bento building, Polo 1, Coimbra, Portugal (Coimbra, Portugal)
2022/04/02 Non-invasive delivery of the brain-targeting AAV-PHP.eB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of spinocerebellar ataxia type 3: a promising therapeutic strategy CONGRESSO SPDMOV (Sociedade Portuguesa das Doenças do Movimento) 2022, April 1, 2
Grande Hotel do Luso, Portugal (Luso, Portugal)
2022/02/21 Induced Pluripotent Stem cells derived from Machado-Joseph Disease patients as a promising model to investigate microRNA dysregulation 52ª reunião da Sociedade Portuguesa de Farmacologia - SPF 2022 (9-11 fevereiro 2022)
ICBAS, Porto, (Portugal)
2022/02/09 Reverting dysregulation of microRNA levels as a promising therapeutic strategy for Machado-Joseph Disease 52ª reunião da Sociedade Portuguesa de Farmacologia - SPF 2022 (9-11 fevereiro 2022)
ICBAS, Porto (Portugal)
2022/02/09 Assessing the potential of mesenchymal stromal cells for alleviation of blood-brain barrier dysfunction in MachadoJoseph Disease 52ª reunião da Sociedade Portuguesa de Farmacologia - SPF 2022 (9-11 fevereiro 2022)
ICBAS, Porto (Portugal)
2022/02/09 Validation of the brain-targeting AAVPHPeB enconding cholesterol hydroxylase CYP46A1 as a therapeutic candidate for Spinocerebellar Ataxia Type-3 52ª reunião da Sociedade Portuguesa de Farmacologia - SPF 2022 (9-11 fevereiro 2022)
ICBAS, Porto (Portugal)
2021/04/21 MiRNA dysregulation in Machado-Joseph Disease Advanced Therapies in the Doctoral Programme in Experimental Biology and Biomedicine (PDBEB)
Center for Neurosciences and Cell Biology (Coimbra, Portugal) (Coimbra)
2021/02/19 IPSC-derived neuroepithelial stem cells depleted for mutant ataxin-3 for Machado-Joseph disease treatment 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia, February 17-19, 2021
Faculdade de Farmácia da Universidade de Lisboa. Virtual meeting (Portugal)
2021/02/19 Phenotypic characterization of neuronal cultures derived from Machado-Joseph disease induced pluripotent stem cells 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia, February 17-19, 2021
Faculdade de Farmácia da Universidade de Lisboa. Virtual meeting (Portugal)
2021/02/18 Allele-specific silencing of Machado-Joseph disease using antisense oligonucleotide therapeutics 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia, February 17-19, 2021
Faculdade de Farmácia da Universidade de Lisboa. Virtual meeting (Portugal)
2021/02/18 Identification of dysregulated mirnas in human induced pluripotent stem cell-based models of Machado-Joseph disease: one step closer to a therapeutic approach? 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia, February 17-19, 2021
Faculdade de Farmácia da Universidade de Lisboa. Virtual meeting (Portugal)
2021/02/18 Unravelling dysregulated micrornas in a transgenic mouse model of Machado-Joseph disease 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia, February 17-19, 2021
Faculdade de Farmácia da Universidade de Lisboa. Virtual meeting (Portugal)
2020/10/14 Thinking Small: Towards microRNA-based therapeutics for Machado-Joseph disease (by Invitation) Neuroscience and Disease Thematic Line Joint DataClub- a forum for discussion
Center for Innovative Biomedicine and Biotechnology (CIBB) (Portugal)
2020/03/03 Autophagy-regulation mediated by microRNAs in Neurodegenerative Diseases (by invitation) American Society for Experimental Neurotherapeutics 2020 (ASENT 2020)
American Society for Experimental Neurotherapeutics (Bethesda MD, Washington DC, United States)
2020/02/05 CRISPR-mediated silencing of mutant ataxin-3 ameliorates motor symptoms of a Machado-Joseph disease model in vivo 50.ª Reunião da Sociedade Portuguesa de Farmacologia, 38.ª Reunião de Farmacologia Clínica e 19.ª Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra , Portugal)
2020/02/05 Human IPSC-derived neuroepithelial stem cells for cell-based therapy in Machad-Joseph disease, 50.ª Reunião da Sociedade Portuguesa de Farmacologia, 38.ª Reunião de Farmacologia Clínica e 19.ª Reunião de Toxicologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2019/12/19 MSC Success in Promoting Ameliorations in Machado-Joseph Disease - Where do We Stand and Where We Should Go? (by invitation) Center for Innovative Biomedicine and Biotechnology (CIBB) Meeting
Center for Innovative Biomedicine and Biotechnology (CIBB) (Coimbra, Portugal)
2019/11/15 Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain disorders 1st Annual Meeting in Pharmaceutical Sciences
Pharmaceutical Sciences (Coimbra, Portugal)
2019/11/15 Human iPSC-derived neuroepithelial stem cells as a source for cell therapy in Machado-Joseph disease 1st Annual Meeting in Pharmaceutical Sciences. November 15, 2019, Coimbra, Portugal
(Portugal)
2019/11/13 "Mecanismos de doença - da alteração genética à disfunção celular e sua manifestação clínica (by invitation) Curso Ataxias hereditárias e paraparésias espásticas: da biologia molecular ao tratamento, Pré - Congresso de Neurologia 2019, November 13, 2019, Coimbra, Portugal
Sociedade Portuguesa de Neurologia (Coimbra, Portugal)
2019/10/10 Spectroscopic Biomarkers as a Way of Monitoring MSC Success in Promoting Neuropathological and Phenotypic Ameliorations in Machado-Joseph Disease Models 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) (Lisbon, Portugal)
2019/05/30 Autophagy activation induced by let-7 microrna overexpression counteracts disease phenotype in Machado-Joseph disease mouse models XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), May 30-June 1, 2019
Portuguese Society for Neuroscience (Lisbon, Portugal)
2019/05/30 Human IPSC-derived neuroepithelial stem cells for cell-based therapies in Machado-Joseph disease XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), May 30-June 1, 2019
Portuguese Society for Neuroscience (Lisbon, Portugal)
2019/05/22 CRISPR interference-mediated silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), May 22-24, 2019
European Society for Clinical Investigation (ESCI) (Coimbra, Portugal)
2019/05/22 Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sus- tainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy (by invitation) 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), May 22-24, 2019
European Society for Clinical Investigation (ESCI) (Coimbra, Portugal)
2019/05/10 Cerebellar transplantation of human iPSC-derived neuroepithelial stem cells for Machado-Joseph disease treatment (by invitation) Neuroscience and Diseases Retreat
Center for Innovative Biomedicine and Biotechnology (CIBB) (Miranda do corvo, Portugal)
2019/02/06 Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica e XVIII Reunião de Toxicologia, February 6-8, 2019
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019/02/06 Human IPSC-derived neuroepithelial stem cells for neuroprotection and neuroregeneration in Machado-Joseph disease XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica e XVIII Reunião de Toxicologia, February 6-8, 2019
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019/02/06 Mutant ataxin-3 spreading in Machado-Joseph disease, XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica e XVIII Reunião de Toxicologia, February 6-8, 2019
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019/01/17 Doenças de expansão de poliglutaminas - Machado-Joseph a ataxia dominante mais comum (by invitation) Conferências IEC and UNISOB
Universidade Sénior de Oliveira do Bairro (UNISOB), an initiative from Instituto de Educação e Cidadania (IEC) in collaboration with UNISOB (Oliveira do Bairro, Portugal)
2018/10/09 Patient-specific iPSC-derived neuroepithelial stem cells for neuroprotection and neuroregeneration in Machado-Joseph disease 10th International Symposium on Neuroprotection and Neurorepair, October 9-11, 2018
Federation of European Neuroscience Societies (Dresden, Germany)
2018/03/02 Let-7 microRNA-based therapy alleviates neuropathology, imbalance and motor incoordination in Machado-joseph disease Congresso da SPDMov 2018 - Genética das Doenças do Movimento, March 2-3, 2018
Sociedade Portuguesa das Doenças do Movimento (SPDMov) (Curia, Portugal)
2018/03/02 Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3 AND therapeutic success can be monitored by 1H-MRS Congresso da SPDMov 2018 - Genética das Doenças do Movimento, March 2-3, 2018
Sociedade Portuguesa das Doenças do Movimento (SPDMov) (Curia, Portugal)
2018/02/05 Let-7 mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease XLVIII Reunião da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia Clínica, e XVII Reunião de Toxicologia, February 5-7, 2018
Sociedade Portuguesa de Farmacologia (SPF) (Lisbon, Portugal)
2018/02/05 Microrna dysregulation in machado-joseph disease: from pathogenesis to therapy XLVIII Reunião da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia Clínica, e XVII Reunião de Toxicologia, February 5-7, 2018
Sociedade Portuguesa de Farmacologia (SPF) (Lisbon, Portugal)
2018/02/05 Repeated mesenchymal stromal cells treatment sustainably alleviates machado-joseph disease XLVIII Reunião da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia Clínica, e XVII Reunião de Toxicologia, February 5-7, 2018
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2017/12/21 Implications of microRNAs dysregulation in Machado-Joseph Disease: From pathogenesis to therapy (by Invitation) 2ND Meeting on Biomedical Research @ UC, December 21st, 2017
(Coimbra, Portugal)
2017/10/12 Human iPSCs-derived NESCs for cerebellar transplantation in Machado-Joseph disease 10th International meeting of the Portuguese society for Stem cells and Cell Therapies, October 12-14, 2017
Portuguese society for Stem cells and Cell Therapies (Covilhã, Portugal)
2017/09/27 Let-7 activates autophagy and alleviates motor and neuropathological deficits in pre- and post-symptomatic Machado-Joseph disease mouse models International Ataxia Research Conference, September 27-30, 2017
Ataxia UK, GoFar (Italian organisation) and FARA (American organisation) (Pisa, Italy)
2011/12/19 Efficient gene delivery and potent antitumoral activity in vitro and in vivo mediated by a new folate (FA)-associated lipoplex formulation IX Annual Meeting - Center for Neurosciences and Cell Biology & Doctoral Programme in Biology and Experimental Biomedicine, December 19-20, 2011
Center for Neurosciences and Cell Biology & Doctoral Programme in Biology and Experimental Biomedicine (coimbra, Portugal)
2009/12/21 Non-covalent strategies combining cationic lipids and CPPs to enhance the delivery of nucleic acids – looking at cellular internalization and biological activity VII Annual Meeting - Center for Neurosciences and Cell Biology & Doctoral Programme in Biology and Experimental Biomedicine, December 21-22, 2009
Center for Neurosciences and Cell Biology & Doctoral Programme in Biology and Experimental Biomedicine (Cantanhede, Portugal)
2009/09/03 Folate receptor-targeting delivery of lipid-based systems aiming at cancer gene therapy GTRV- Summer School «Targeted Drug Delivery», September 3-4, 2009
(Lausanne, Switzerland)
2009/08/31 Optimization of S4(13)-PV cell penetrating peptide-based vectors for the delivery of nucleic acids – study of cellular internalization and biological activity 3rd Intracellular Delivery of Therapeutic Molecules: From Bench to Bedside, August 31-September 2, 2009
(Montpellier, France)
2008/08/30 S413-PV cell penetrating peptide associated with different cargos: assessment of delivery efficiency and internalization mechanisms Cell-Penetrating Peptides Satellite Symposium of the 30th European Peptide Symposium, August 30-31, 2008
European Peptide Society (EPS) and the Finnish Peptide Society (FIPS) (Helsinki, Finland)
2006/08/27 Simultaneous purification and condensation of plasmid DNA with PEGylated Polyethyleneimine in Aqueous Two-Phase Systems 6th European Symposium on Biochemical Engineering Science (ESBES 6) | August 27 - 30, 2006
European Society of Biochemical Engineering Sciences (Salzburg, Austria)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2020/09 - Current Thesis: Unravelling microRNA dysregulation in Machado-Joseph Disease models (Co-supervisor Luis Pereira de Almeida, PhD)
Supervisor of José Miguel Amaral Pinto
Master in Pharmaceutical Biotechnology (Master)
2022/09 - 2024/03/19 Thesis: Identify miRNA-specific small molecules capable of selectively modulate miRNA levels (Co-supervisor Luis Pereira de Almeida, PhD)
Supervisor of Micaela Figueiredo Pintor
Master in Pharmaceutical Biotechnology (Master)
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2022/02/16 - 2023/02/15 Supervision of MSc Research fellow hired under the project funded by AFM 23755 entitled "Repurposing FDA-approved Drugs as microRNA-specific modifiers towards a new and promising therapeutic approach for Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3)"
Supervisor of Maria Inês Nunes dos Santos
Center for Neurosciences and Cell Biology, Portugal
2019/07/01 - 2022/02/28 Supervisor of the Post-Doctoral Researcher hired for the project funded by FCT (POCI-01-0145-FEDER-032309) entitled "Role of microRNA deregulation in Machado-Joseph Disease: On the development of a microRNA-based therapeutic strategy".
Supervisor of Diana Isabel da Silva Santos
Center for Neurosciences and Cell Biology, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2021/04/05 - 2021/10/04 Supervision of MSc Research fellow hired under the project funded by FCT (POCI-01-0145-FEDER-032309) entitled "Role of microRNA deregulation in Machado-Joseph Disease: On the development of a microRNA-based therapeutic strategy"
Supervisor of Maria Inês Nunes dos Santos
Center for Neurosciences and Cell Biology, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019/09/02 - 2020/12/16 Thesis: MicroRNA profiling in human cell-based models of Machado-Joseph disease (Co-supervisor Luis Pereira de Almeida, PhD)
Supervisor of Maria Inês Nunes dos Santos
Master in Pharmaceutical Biotechnology (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/09 - 2018/09/26 Thesis: The role of autophagy activation mediated by Let-7 in a transgenic mice model of Machado-Joseph Disease (Co-supervisor Carlos B. Duarte)
Supervisor of Beatriz Filipa Varela Estremores
Master in Molecular and Cell Biology, University of Coimbra (Master)
Center for Neurosciences and Cell Biology, Portugal

Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015/09 - 2016/09/09 Thesis: Autophagy deregulation in models of Parkinson's disease and Machado-Joseph disease (Co-supervisors Rita Perfeito, PhD and Luis Pereira de Almeida, PhD)
Supervisor of Chiara Soricelli
Master in Molecular and Cell Biology, University of Coimbra (Master)
Center for Neurosciences and Cell Biology, Portugal

Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2008 - 2009 Supervision of the project student/scientific internship
Supervisor of Cláudia Pinho
Bachelor Degree in Biochemistry, Faculty of Science and Technology, University of Coimbra, Portugal
2007 - 2008 Co-supervision of the project student/scientific internship under the topic "Development of antisense oligonucleotides delivery systems for splice correction"
Co-supervisor of Sara Varela Amaral
Degree in Biochemistry (Degree)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2006 - 2006 Participation in the Organization of the International Symposium: Agents for Molecular therapy: Preparation and applications, September 15th, 2006 in the School of Sciences, University of Minho, Braga (2006/09/15)
Symposium (Member of the Organising Committee)
Universidade do Minho, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2023/01/10 - 2023/01/10 Participating as Doctoral investigator in the Conference "Ética, Integridade e Transparência", January 10th, 2023, Auditório da Reitoria, University of Coimbra.
Conference
Conference "Ética, Integridade e Transparência"
Universidade de Coimbra, Portugal
2022/12/19 - 2022/12/19 Participating as Doctoral investigator in Encontro CIBB 2022 I CIBB Meeting 2022 at the Auditório da Unidade Central do Polo III
Meeting
Encontro CIBB 2022 I CIBB Meeting 2022
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2022/11/19 - 2022/11/19 Participating as Doctoral Investigator in the Event with MJD patients, INICIATIVA EUROPEIA para a Doença de Machado-Joseph: Passado, Presente e Futuro, November 19th, 2022, Exploratório, Coimbra
Meeting
INICIATIVA EUROPEIA para a Doença de Machado-Joseph: Passado, Presente e Futuro
Exploratório, Portugal
2022/09/30 - 2022/09/30 Participated as Doctoral Investigator in the activity "To be or not to be a GreenLab | Que tipo de plástico sou?, Less plastic, more planet!", European Researchers'Night, September 30, 2022, Baixa de Coimbra. https://noiteeuropeiadosinvestigadores.uc.pt/ https://www.facebook.com/photo/?fbid=10160084047153908&set=a.436047723907
Exhibition
European Researchers' Night
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Center for Neurosciences and Cell Biology, Portugal

Universidade de Coimbra, Portugal
2021/12/20 - 2021/12/20 Participting as a Doctoral Researcher in the CIBB MEETING 2021 (Online via Zoom)
Meeting
CIBB MEETING 2021
Center for Neurosciences and Cell Biology, Portugal
2021/11/24 - 2021/11/24 Participated as Doctoral Investigator in the activity of Science communication "Falando sobre o cérebro e construção de neurónios" for students at primary school of Bairro Norton de Matos. Event: https://www.facebook.com/media/set/?set=a.607551827328220&type=3
Exhibition
Semana da Ciência e Tecnologia 2021
Center for Neurosciences and Cell Biology, Portugal
2021/11/17 - 2021/11/18 Participting as Doctoral Investigator in the "2nd Retreat of CIBB's Metabolism, Aging and Disease Area". (Both live and virtual)
Meeting
2nd Retreat of CIBB's Metabolism, Aging and Disease Area
Center for Neurosciences and Cell Biology, Portugal
2021/05/24 - 2021/05/25 Participating as Doctoral Investigator in the 3rd CIBB Neuroscience and Disease retreat (Online via Zoom)
Meeting
3rd CIBB Neuroscience and Disease retreat
Center for Neurosciences and Cell Biology, Portugal
2021/01/20 - 2021/01/20 Participating as Doctoral Investigator in the Joint DataClub of Neuroscience and Disease Thematic Line
Conference
Neuroscience and Disease Thematic Line- Joint DataClub
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2020/10/14 - 2020/10/14 Participating as Doctoral Investigator in the event "O Cérebro e Ambiente: O Impacto da Pandemia"
Seminar
"O Cérebro e Ambiente: O Impacto da Pandemia"
Center for Neurosciences and Cell Biology, Portugal

Universidade do Algarve Centro de Investigação em Biomedicina, Portugal

Sociedade Portuguesa de Neurociências, Portugal
2020/09/19 - 2020/09/19 Participating as Doctoral Investigator in the 2nd CIBB INNOVATIVE THERAPIES RETREAT 2020
Conference
2nd CIBB INNOVATIVE THERAPIES RETREAT 2020
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2020/07/08 - 2020/07/08 Participating as Doctoral Investigator in the CIBB Neuroscience and Disease Online Retreat
Meeting
CIBB Neuroscience and Disease Online Retreat
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2020/02/29 - 2020/02/29 Participation as Doctoral investigator in the event "Doença de Machado-Joseph: do Laboratório para a Sociedade, 2ª Edição" at the Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, February 29th 2020.
Meeting
“Doença de Machado-Joseph: do Laboratório para a Sociedade, 2ª Edição”
Center for Neurosciences and Cell Biology, Portugal
2019/10/04 - 2019/10/04 Workshop: How to write a Great Research Paper, and Get it Accepted by a Good Journal.
Workshop
How to Get Published
Elsevier Ltd, United Kingdom
2019/10/03 - 2019/10/03 Workshop: First Aid Course | Formação em primeiros socorros
Workshop
First Aid Course provided by HIORSE (Hygien, Safety and Health at Work, LDA)
CNC.IBILI, Portugal
2019/09/27 - 2019/09/27 Participation as Doctoral investigator in the initiative European Researcher's night at the Jardim Botânico of University of Coimbra, September 27 2019.
Other
“European Researcher’s night”
Universidade de Coimbra, Portugal
2019/09/26 - 2019/09/26 Workshop: AniBio Software
Workshop
AniBio Software
Center for Neurosciences and Cell Biology, Portugal
2019/05/13 - 2019/05/13 Participation as Doctoral Investigator in the initiative "Escola Ciência Viva" at the Rómulo centro de Ciência viva of University of Coimbra, May 13rd 2019.
Other
“Escola Ciência Viva”
Rómulo Centro de Ciência Viva da Universiade de Coimbra, Portugal
2019/05/10 - 2019/05/10 Participating as Doctoral Investigator in the CIBB Neuroscience and Disease 1st Retreat, Miranda do Corvo, Portugal.
Meeting
CIBB Neuroscience and Disease 1st Retreat
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2012 - 2019 Participation as a Post-Doc Researcher in scientific divulgation related activities as part of the programmes "Brain Awareness Week" from 2012 - 2019.
Other
“Brain Awareness Week”
Center for Neurosciences and Cell Biology, Portugal
2012 - 2019 Participation as a Post-Doc Researcher in scientific divulgation related activities as part of the programme "National Science and Technology week" from 2012 - 2019.
Other
“National Science and Technology week”
Center for Neurosciences and Cell Biology, Portugal
2018/03/23 - 2018/03/23 Overcoming Challenges in Scientific Careers, Biomedical Research Post-Doctoral Forum @ UC, March 23rd, 2018, Faculty of Medicine- Polo III, University of Coimbra.
Symposium
“Overcoming Challenges in Scientific Careers”, Biomedical Research Post-Doctoral Forum
Universidade de Coimbra, Portugal
2018/02/28 - 2018/02/28 Participating as Doctoral Investigator in the event with MJD patients "Doença de Machado-Joseph: do Laboratório para a Sociedade" at the Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, February 28th 2018.
Meeting
“Doença de Machado-Joseph: do Laboratório para a Sociedade”
Center for Neurosciences and Cell Biology, Portugal
2017/05/22 - 2017/05/23 Participating as Post-Doc researcher in the 2nd EU joint Programme-Neurodegenerative Disease research (JPND) - European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative (ESMI) Meeting, Coimbra, Portugal
Conference
2nd EU joint Programme-Neurodegenerative Disease research (JPND) - European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative (ESMI) Meeting
Center for Neurosciences and Cell Biology, Portugal

EU Joint Programme Neurodegenerative Disease Research, Germany
2016/12/19 - 2016/12/20 Participating as Post-Doc researcher in the 1st meeting on Biomedical research at UC, Polo III Auditorium, University of Coimbra, Portugal.
Meeting
1st meeting on Biomedical research
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2016/11/18 - 2016/11/19 Participating as Post-Doc researcher in the Brain With]Out[Borders, Museu da Ciência, University of Coimbra, Portugal.
Meeting
Brain With]Out[Borders,
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2015/02/04 - 2015/02/06 Participating as Post-Doc researcher in the TreatPolyQ Final Meeting, Museum, Coimbra, Portugal.
Conference
TreatPolyQ Final Meeting
Center for Neurosciences and Cell Biology, Portugal
2012/12/04 - 2012/12/06 Advanced Fluorescence Microscopy Workshop at the Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, 4-6 December 2012.
Workshop
Advanced Fluorescence Microscopy Workshop
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008 - 2012 Participation as a PhD student in scientific divulgation related activities as part of the programme "Brain Awareness Week" from 2008 - 2012.
Other
“Brain Awareness Week"
Center for Neurosciences and Cell Biology, Portugal
2008 - 2012 Participation as a PhD student in scientific divulgation related activities as part of the programme National Science and Technology week from 2008 - 2012.
Other
“National Science and Technology week”
Center for Neurosciences and Cell Biology, Portugal
2009 - 2009 Participation as PhD student researcher in the event Cientistas ao Palco during the Researchers' Night international initiative (2009).
Other
“Cientistas ao Palco” during the “Researchers’ Night 2009” international initiative
Center for Neurosciences and Cell Biology, Portugal
2005/02 - 2006/02 Participation in the public initiative "Portas Abertas do Departamento de Química- Organização de actividades de divulgação científica", organized by the Biological Chemistry group in February 2005, University of Minho, Braga "Portas Abertas do Departamento de Química- Organização de actividades de divulgação científica"
Universidade do Minho, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2024/03/19 Identifying Mirna-Specific Small Molecules Capable of Selectively Modulate Mirna Levels in Machado-Joseph Disease Models
Supervisor
Micaela Figueiredo Pintor (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal

Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2020/12/16 Thesis tilte "MICRORNA PROFILING IN HUMAN CELL-BASED MODELS OF MACHADO-JOSEPH DISEASE"
Supervisor
Maria Inês Nunes dos Santos (Master)
Center for Neurosciences and Cell Biology, Portugal

Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/09/26 Thesis title "The role of autophagy activation mediated by Let-7 in a transgenic mice model of Machado-Joseph Disease"
Supervisor
Beatriz Filipa Varela Estremores (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2017/03/21 Thesis title "Role of microRNA deregulation in the pathogenesis of Machado-Joseph disease"
(Thesis) Arguer
Udaya Geetha Vijayakumar (PhD)
Universidade de Coimbra, Portugal
2016/09/28 Thesis title "MicroRNA based therapeutic approaches for obesity"
(Thesis) Main arguer
Ana Rita Carvalho Samões (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/09/09 Thesis title "Autophagy deregulation in models of Parkinson's disease and Machado-Joseph disease"
Supervisor
Chiara Soricelli (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Association member

Society Organization name Role
2019 - Current Sociedade Portuguesa de Neurociências (SPN) membership Society membership
2019 - Current FENS (Federation of European Neuroscience Societies)
2016 - Current European Society of Gene and Cell Therapy (ESGCT) Academic Membership Society membership
2008 - Current Portuguese Biochemical Society (SPB) Membership Society Membership

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/04/13 - 2022/04/13 Lecture on the topic "Thinking small: miRNA-mediated gene silencing and miRNA-based therapeutic approaches" Advanced Therapies in the Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) (Doutoramento) Center for Neurosciences and Cell Biology, Portugal

Universidade de Coimbra, Portugal
2021/04/21 - 2021/04/21 Lecture on the topic "Thinking small: miRNA-mediated gene silencing and miRNA-based therapeutic approaches" Advanced Therapies in the Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) (Doutoramento) Center for Neurosciences and Cell Biology, Portugal
2020/12/11 - 2020/12/11 Lecture on the topic "Papel regulador dos microRNAs na expressão génica" Gene and Cell Therapy course of the graduation in Biomedical Sciences (Licenciatura) Universidade do Algarve - Campus de Gambelas, Portugal
2020/10/07 - 2020/10/07 Lecture on the topic "Thinking Small: Towards microRNA-based therapeutics" Summer Course Metodologias de Investigação Científica (Curso Não Conferente de Grau do IIIUC) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2020/04/04 - 2020/04/04 Lecture on the topic "Papel regulador dos microRNAs na expressão génica" MÓDULO VIII: TERAPÊUTICA MOLECULAR E ENGENHARIA DE TECIDOS of the Master Course of Pharmaceutical Biotechnology (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/11/26 - 2019/11/26 Lecture on the topic "Autophagy in Machado-Joseph Disease" Curso de Regulação Celular in the Biomedical Investigation Master (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal

CNC.IBILI, Portugal
2019/04/23 - 2019/04/23 Lecture on the topic "MicroRNAs-mediated gene silencing in Neurodegenerative disorders" Advanced Therapies in the Doctoral Programme in Experimental Biology and Biomedicine (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/03/30 - 2019/03/30 Lecture on the topic "Papel regulador dos microRNAs na expressão génica" Módulo VIII: Terapêutica Molecular e Engenharia de tecidos of the Master Course of Pharmaceutical Biotechnology (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/05/08 - 2018/05/08 Lecture on the topic "MicroRNAs-mediated gene silencing in Neurodegenerative disorders" Advanced Therapies in the Doctoral Programme in Experimental Biology and Biomedicine (Doutoramento) Center for Neurosciences and Cell Biology, Portugal
2018/04/21 - 2018/04/21 Lecture on the topic "Papel regulador dos microRNAs na expressão génica" Módulo VIII: Terapêutica Molecular e Engenharia de tecidos in the Pharmaceutical Biotechnology Master (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/09/26 - 2017/10/06 Lecture on the topic "Stereotaxic surgery" Course of Sciences in Laboratory Animals-Module 21: “advanced anaesthesia for surgical or prolonged procedures in mice and rats” and Module 22: “Principles of surgery (skills)” (Curso de Especialização Tecnológica) CNC.IBILI, Portugal
2017/03/25 - 2017/03/25 Lecture on the topic "Papel regulador dos microRNAs na expressão génica" Módulo VIII: Terapêutica Molecular e Engenharia de tecidos in the Pharmaceutical Biotechnology Master (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/06/16 - 2016/06/16 Lecture on the topic "Let-7 activates autophagy and alleviates Machado-Joseph Disease" Advanced Therapies in the Doctoral Programme in Experimental Biology and Biomedicine (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/10 - 2012/10 Lecture on the topic "Western Blot and Immunohistochemistry" Doctoral Programme in Health Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2021/11/24 "Falando sobre o cérebro e construção de Neurónios" at Primary school of Bairro Norton de Matos 3.ª edição do "Bairrinho Notícias"

Interview (tv / radio show)

Program Topic
2017/09/28 - Current Interviewed at #IARC2017 under the program International public promotion in Friedreich's Ataxia News, BioNews Services, LLC, of the research projects ongoing #IARC2017 – MicroRNA Delivered to Brain Seen to Ease Neurological and Motor Problems in Machado-Joseph Mouse Model

Journal scientific committee

Journal title (ISSN) Publisher
2013/07 - Current Acta Neuropathologica (ANP-D-13-00404) Springer

Mentoring / Tutoring

Topic Student name
2020/08 - 2020/10 Mentoring and Evaluation in the Summer Course "Metodologias de investigação científica - I&D: Terapia génica e células estaminais" Maria Inês Nunes dos Santos
2019/07 - 2019/09 Mentoring of Laboratory Rotation Maria Inês Nunes dos Santos
2019/04/11 - 2019/07/21 Mentoring of Lab rotation of Master in Pharmaceutical Biotechnology Maria Inês Nunes dos Santos
2019/04 - 2019/07/12 Mentoring and Evaluation of Thesis Project Defense "MicroRNA profiling in Machado-Joseph Disease-On the development of a New Therapeutic Strategy" Maria Inês Nunes dos Santos
2019/04 - 2019/06 Mentoring of Lab rotation of Master in Pharmaceutical Biotechnology Maria Pinto
2019/04 - 2019/06 Mentoring of Lab rotation of Master in Pharmaceutical Biotechnology Ana Daniela Oliveira
2018/09 - 2019/02 Mentoring of Labrotation of Master in Pharmaceutical Biotechnology José Miguel Amaral Pinto
2017/07/05 - 2017/07/28 Mentoring and Evaluation of the Seminar in Neurobiology I Beatriz Filipa Varela Estremores
2017/07/01 - 2017/07/14 Mentoring of the Seminar in Neurobiology II Beatriz Filipa Varela Estremores
2017/06/05 - 2017/06/30 Mentoring of Laboratory Rotation III of Master in Molecular and Cell Biology, University of Coimbra Beatriz Filipa Varela Estremores
2017/01/30 - 2017/02/24 Mentoring of Laboratory Rotation I of Master in Molecular and Cell Biology, University of Coimbra Beatriz Filipa Varela Estremores
2008 - 2009 Laboratory co-supervision of a project student Liliana Antunes
2008 - 2009 Laboratorial co-supervision of a project student (Bachelor Degree in Biochemistry, Faculty of Science and Technology, University of Coimbra, Portugal) Joana Guedes

Other jury / evaluation

Activity description Institution / Organization
2023/12/07 - 2023/12/07 President of the Jury for the assignment of a Research Fellowship | IT137-23-392, under the project REPURPOSING FDA-APPROVED DRUGS AS MICRORNASPECIFIC MODIFIERS TOWARDS A NEW AND PROMISING THERAPEUTIC APPROACH FOR MACHADO JOSEPH DISEASE/SPINOCEREBELLAR ATAXIA TYPE 3 (MJD/SCA3) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2022/01/27 - 2022/01/27 President of the Jury for the assignment of a Master Researcher Fellowship (BI - AFM 23755 | Lugus 780589) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Center for Neurosciences and Cell Biology, Portugal
2021/02 - 2021/02 President of the Jury for the assignment of a Master Researcher Fellowship (BI - Atividades de I&D a realizar por estudantes de doutoramento ou mestres inscritos em cursos não conferentes de grau académico_BI: 032309) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/07/28 - 2020/07/28 Jury member for the assignment of Twelve Research Fellowships (BI- Curso de Verão "Metodologias de investigação científica - I&D: Terapia génica e células estaminais" | 12 BI | Lugus 685385) Universidade de Coimbra, Portugal
2020/07/28 - 2020/07/28 Jury member for the assignment of a Initiation Research Fellowship (BII-Curso de Verão "Metodologias de investigação científica - I&D: Terapia génica e células estaminais" | 1 BII | Lugus 685393 Universidade de Coimbra, Portugal
2019/11/19 - 2019/11/19 Jury member for the assignment of an MSc researcher fellowship (BIM POCI-01-0145-FEDER-030737) Center for Neurosciences and Cell Biology, Portugal
2019/05/06 - 2019/05/06 Jury member of an International selection tender procedure for Doctorate hiring (INV JR 2019 Nº 45. 032309) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/03/15 - 2019/03/15 Jury member in the application for Master fellowship with reference BIM 7.3, under the project BrainHealth 2020 - Detecção Precoce, Neuromodulação e Terapias Avançadas para Neuropatologias (CENTRO-01-0145-FEDER-000008) Center for Neurosciences and Cell Biology, Portugal
2018/11/19 - 2018/11/19 Jury member in the application for Master fellowship with reference BIM POCI-01-0145-FEDER-030737 Center for Neurosciences and Cell Biology, Portugal
Distinctions

Award

2021 NAF Young Investigator Award 2021
National Ataxia Foundation, United States
2021 AFM Trampolin Grant - 23755
AFM-Téléthon, France
2020 Travel Stipend awarded poster presenter to attend Ataxia Investigators Meeting (AIM) 2020
National Ataxia Foundation, United States
2012 Post-Doc fellowship (SFRH / BPD / 87552 / 2012) under a highly competitive application
Fundação para a Ciência e a Tecnologia, Portugal
2008 PhD fellowship (SFRH/BD/39727/2007) under a highly competitive application
Fundação para a Ciência e a Tecnologia, Portugal
2003 Fellowship under PRODEPIII-estágios 2003/2004
Universidade de Coimbra, Portugal

Other distinction

2019 PhD/Doctoral Research contract under DL 57/2016 (NT CNC 2018.01-35, position 8)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Fundação para a Ciência e a Tecnologia, Portugal
2018 PhD/Doctoral Research contract under the project POCI-01-0145-FEDER-032309
Fundação para a Ciência e a Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017 Work selected to be disseminated in Friedreich’s Ataxia News, BioNews Services, LLC "#IARC2017 – MicroRNA Delivered to Brain Seen to Ease Neurological and Motor Problems in Machado-Joseph Mouse Model."
2012 Research Fellowship under the project PTDC/SAU-FAR/116535/2010
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007 Research Fellowship under the project PTDC/BIO/65627/2006
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005 Research Fellowship under the Project POCTI BIO/47245/2002
Universidade do Minho, Portugal