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Identification

Personal identification

Full name
Sónia Patrícia Dias Duarte

Citation names

  • Duarte, S.P.
  • Duarte S.
  • Sónia P. Duarte

Author identifiers

Ciência ID
CD1E-CEC0-AFFC

Email addresses

  • sonia.duarte@cnc.uc.pt (Professional)

Telephones

Telephone
  • 239820190 (Professional)

Addresses

  • Centro de Inovação em Biomedicina e Biotecnologia (CIBB)/Centro de Neurociências e Biologia Celular (CNC). Universidade de Coimbra, Rua Larga, Faculdade de Medicina Pólo I, 1º andar, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Websites

Education
Degree Classification
2023/03/08 - 2023/03/08
Concluded
 Webinar on Enabling and advancing mRNA-LNP medicines from concept to clinic (VACCINE INSIGHTS) (Outros)
Bioinsights Publishing, United Kingdom
2023/03/01 - 2023/03/01
Concluded
 Webinar on Optimize your mRNA process from pDNA template to LNP encapsulation (CELL & GENE THERAPY INSIGHTS) (Outros)
Bioinsights Publishing, United Kingdom
2020/06/18 - 2020/06/18
Concluded
 X-omics workshop: data standards and multi-omics data integration (Outros)
X-omics Organization, Netherlands
2020/06/10 - 2020/06/10
Concluded
 Workshop: "QIAGEN miRNA solutions" (Outros)
QIAGEN LLC, United States
2019/06/12 - 2019/06/12
Concluded
 Workshop: "Everything you need to know about miRNA qPCR" (Outros)
QIAGEN LLC, United States
2013/02/01 - 2018/07/04
Concluded
 Investigating the role of the Let-7 microRNA in Machado-Joseph disease (Pós-doutoramento)
Major in Neurosciences
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 N/A
2015/07/16 - 2015/07/16
Concluded
 Workshop: Bioestatística para trabalhos de investigação (Outros)
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2015/02/05 - 2015/02/06
Concluded
 Neuroepigenetics Advanced course of BEB PhD programme (Outros)
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2014 - 2014
Concluded
 Course in laboratory animal science- category B + Certificate of Researcher-coordinator for the practice of animal experimentation (Outros)
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal

Direcção-Geral de Alimentação e Veterinária, Portugal
2013/01/15 - 2013/01/17
Concluded
 Workshops at the Biogenesis and turnover of small RNAs meeting from Biochemical Society, Advancing Molecular Bioscience (Outros)
Biochemical Society, United Kingdom

Royal Society of Edinburgh, United Kingdom
2008/03/01 - 2012/07/24
Concluded
 PhD in Biochemistry (Doutoramento)
Major in Biochemical Technology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"On the development of antitumoural therapeutic strategies: Suicide gene therapy mediated by lipid-based systems and cancer stem cell-based vaccination" (THESIS/DISSERTATION)
 PhD with distinction and honors approved by unanim
2009/10 - 2010/07
Concluded
 Advanced Communication Skills in English I and II (Outros)
Universidade de Coimbra Faculdade de Letras, Portugal
2010/04 - 2010/06
Concluded
 Curso de Formação Inicial de Formadores to acquire the CAP certificate (106 h) (Outros)
Tecla Center, Portugal
2010/03/04 - 2010/03/05
Concluded
 Workshop: "RNA Therapeutics" (Outros)
Harvard Medical School, United States

Fundação Calouste Gulbenkian, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
2009/09/03 - 2009/09/04
Concluded
 GTRV- Summer School « Targeted Drug Delivery » (Outros)
École Polytechnique Fédérale de Lausanne, Switzerland
2005/02/22 - 2005/02/25
Concluded
 Advanced Course on Gene Therapy (Outros)
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2000/09 - 2004/07/23
Concluded
 Biochemistry (Licenciatura)
Major in Biochemistry
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Validação de uma técnica de HPLC para determinação de anti-inflamatórios do grupo do Etofenamato" (THESIS/DISSERTATION)
 Final grade of 16 (out of 20).
Affiliation

Science

Category
Host institution 		Employer
2023/09/01 - Current Research Assistant (Research) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2019/02/01 - 2023/08/31 Contracted Researcher (Research) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2018/07/05 - 2019/01/31 Contracted Researcher (Research) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2013/02/01 - 2018/07/04 Postdoc (Research) Foundation for Science and Technology (Lisbon, Portugal) , Portugal
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2012/06/01 - 2012/12/31 Postdoc (Research) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2008/03/01 - 2012/07/24 Researcher (Research) Foundation for Science and Technology (Lisbon, Portugal) , Portugal
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2011/05/01 - 2011/08/05 Visiting Researcher (Research) Foundation for Science and Technology (Lisbon, Portugal) , Portugal
Centre National de la Recherche Scientifique (UMR 6235 CNRS), France
2010/09/06 - 2010/12/20 Visiting Researcher (Research) Foundation for Science and Technology (Lisbon, Portugal) , Portugal
Centre National de la Recherche Scientifique (UMR 6235 CNRS), France
2007/06/01 - 2008/02/29 Researcher (Research) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2005/01/01 - 2007/05/31 Researcher (Research) Universidade do Minho, Portugal
Universidade do Minho, Portugal
2003/09/01 - 2004/07/31 Research Trainee (Research) Laboratorios Basi S.A.-Industria Farmaceutica, Portugal
Laboratorios Basi S.A.-Industria Farmaceutica, Portugal

Others

Category
Host institution 		Employer
2023/04/05 - 2023/09/01 CAREER BREAK: Maternity Leave: Coimbra, Portugal Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2014/07/01 - 2015/01/01 CAREER BREAK: Pregnancy/Maternity Leave: Coimbra, Portugal Foundation for Science and Technology (Lisbon, Portugal) , Portugal
Center for Neurosciences and Cell Biology, Portugal
Projects

Grant

Designation Funders
2023/03/01 - Current Pre-clinical evaluation of the brain-targeting AAV-PHP.eB encoding cholesterol hydroxylase CYP46A1 as a therapeutic strategy for spinocerebellar ataxia type 3 - towards the understanding of the neuroprotective mechanism
2022.04788.PTDC
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2023/01/01 - Current Direct Conversion of Astrocytes into Cerebellar Neurons as an Innovative Treatment for Spinocerebellar Ataxia Type-3
2022.06127.PTDC
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/09/01 - 2024/02/28 MicroRNA-specific small molecule modifiers as a new and promising therapeutic approach for Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3)
NAF Young Investigator Award
Principal investigator
Center for Neurosciences and Cell Biology, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
National Ataxia Foundation
Ongoing
2021/09/16 - 2024 "Repurposing FDA-approved Drugs as microRNA-specific modifiers towards a new and promising therapeutic approach for Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3)"
Trampoline Grant 23755
Principal investigator
Center for Neurosciences and Cell Biology, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
AFM-Téléthon
Ongoing
2018/07/06 - 2022/04/05 Role of microRNA deregulation in Machado-Joseph Disease: On the development of a microRNA-based therapeutic strategy
POCI-01-0145-FEDER-032309
Principal investigator
Center for Neurosciences and Cell Biology, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Fundação para a Ciência e a Tecnologia

Comissão de Coordenação e Desenvolvimento Regional do Centro
Ongoing
2020 - 2022/02/28 Intravenous delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of spinocerebellar ataxia type 3: a promising non-invasive therapeutic strategy
686213
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 National Ataxia Foundation
2019 - 2021/12 Gene Therapy for Cerebellar Ataxias: restoring cholesterol metabolism by targeting brain cholesterol 24 hydroxylase (CYP46A1) - SCA-CYP (International Consortium)
E-Rare-3 JTC 2017 (International Consortium)
Researcher
CNC.IBILI, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2018/06 - 2021/06 The impact of induced pluripotent stem cells-derived neuroepithelial stem cells transplantation in Machado-Joseph disease
POCI-01-0145-FEDER-030737
Researcher
Center for Neurosciences and Cell Biology, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro

Fundação para a Ciência e a Tecnologia
Ongoing
2017/01 - 2020/12 BRAIN HEALTH 2020-Detecção Precoce,Neuro-modulação e TerapiasAvançadas para Neuropatologias
CENTRO-01-0145-FEDER-000008
Researcher
Center for Neurosciences and Cell Biology, Portugal
 Centro2020 - Programa Operacional Centro 2020 (FEDER/FSE)

Foundation for Science and Technology (Lisbon, Portugal)
Ongoing
2016/04 - 2020/05 ModelPolyQ: Advanced models of polyglutamine disorders (HD, SCA3 and SCA7)
JPCOFUND/0005/2015 (International Consortium)
Researcher
Center for Neurosciences and Cell Biology, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
EU Joint Programme Neurodegenerative Disease Research
2016 - 2020/05 JPND European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative
JPCOFUND/0001/2015-ESMI (International Consortium)
Researcher
Center for Neurosciences and Cell Biology, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
EU Joint Programme Neurodegenerative Disease Research
Ongoing
2017/03/27 - 2020/03/26 LifeSciences ByCENTRO
CENTRO-01-0246-FEDER-000011
Researcher
CNC.IBILI, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Centro2020 - Programa Operacional Centro 2020 (FEDER/FSE)
2016/04 - 2019/03 Gene repair and repression strategies to alleviate Machado-Joseph disease
PTDC/NEU-NMC/0084/2014
Researcher
Center for Neurosciences and Cell Biology, Portugal
 Foundation for Science and Technology (Lisbon, Portugal)
Concluded
2015/03 - 2018/12 Roles and mechanisms of synuclein and ataxin-3 spreading in Parkinson and Machado-Joseph diseases
JPND SynSpread: CD/0001/2013 (International consortium)
Researcher
Center for Neurosciences and Cell Biology, Portugal
 EU Joint Programme Neurodegenerative Disease Research

Foundation for Science and Technology (Lisbon, Portugal)
Concluded
2013/02/01 - 2018/07/04 Investigating the role of the Let-7 microRNA in Machado-Joseph disease
SFRH/BPD/87552/2012
Post-doc Fellow
Center for Neurosciences and Cell Biology, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/03 - 2016/02 Machado-Joseph-Disease, protein aggregation, protein degradation, stem cell biology, proteostasis, neurodegeneration
E-Rare4/0003/2012 (International consortium)
Researcher
Center for Neurosciences and Cell Biology, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/03 - 2015/08 Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease
PTDC/BIM-MEC/0651/2012
Researcher
Center for Neurosciences and Cell Biology, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/03 - 2015/06 Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid-based nanosystem for systemic delivery
PTDC/DTP-FTO/0265/2012
Researcher
Center for Neurosciences and Cell Biology, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/06 - 2012/12 Non-invasive Non-viral Silencing of Machado-Joseph disease
PTDC/SAU-FAR/116535/2010
Research Fellow
Center for Neurosciences and Cell Biology, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/03/01 - 2012/03/01 ON THE DEVELOPMENT OF ANTITUMOURAL THERAPEUTIC STRATEGIES: Suicide gene therapy mediated by lipid-based systems and cancer stem cell-based vaccination
SFRH/BD/32797/2007
PhD Student Fellow
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Center for Neurosciences and Cell Biology, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/06 - 2008/02 Development of a novel approach for anti-tumor therapy based on the S413-PV cell penetrating peptide to improve the intracellular delivery of therapeutic proteins and nucleic acids
PTDC/BIO/65627/2006
Research Fellow
Center for Neurosciences and Cell Biology, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/01 - 2007/05 Preparação de agentes para Terapia Molecular por purificação e condensação simultânea de plasmídeos em sistemas de duas fases aquosas
POCTI BIO/47245/2002
Research Fellow
Universidade do Minho, Portugal
 Universidade do Minho
Concluded

Contract

Designation Funders
2020/07 - Current "miRSilencing" project
international collaborative project between the Center for Neuroscience and Cell Biology (CNC, UC, Portugal) and PTC Therapeutics (USA)
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
PTC Therapeutics Inc
Ongoing
2018/05 - Current "Targeting mutant ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using allele-specific ASOs
International collaborative project between CNC and Wave Life Sciences USA, Inc
Researcher
Center for Neurosciences and Cell Biology, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Wave Life Sciences USA, Inc
Ongoing
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Center for Innovative Biomedicine and Biotechnology
UIDB/04539/2020
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2019/02 - 2019/10 Targeting ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using AAV5 and an artificial microRNA
International Collaborative Project between CNC and uniQure Company
Researcher
Center for Neurosciences and Cell Biology, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
uniQure NV
Concluded
2015/01 - 2017/12 “CNC. IBILI”
UID/NEU/04539/2013
Researcher
Center for Neurosciences and Cell Biology, Portugal
 Foundation for Science and Technology (Lisbon, Portugal)
Concluded

Other

Designation Funders
2018 - Current Lab management (organizing/ordering/managing the lab products, space/people in the lab)
LAB MANAGMENT
Other
Center for Neurosciences and Cell Biology, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Ongoing
2013 - Current Collaboration with La Spada AR, who first discovered polyglutamine disorders at the University of Duke
INTERNATIONAL NETWORK
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Ongoing
Outputs

Publications

Book chapter
  1. Nóbrega, Clévio; Simões, Ana Teresa; Duarte-Neves, Joana; Duarte, Sónia; Vasconcelos-Ferreira, Ana; Cunha-Santos, Janete; Pereira, Dina; et al. "Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis". In Polyglutamine Disorders in Advances in Experimental Medicine and Biology, 349-367. Springer International Publishing, 2018.
    Published • 10.1007/978-3-319-71779-1_18
  2. Cardoso, Ana Luísa; Trabulo, Sara; Duarte, Sónia; Costa, Pedro M; Pereira de Almeida, Luis; Pedroso De Lima, M.C.. "Gene silencing as a promising strategy to target CNS and neurological disorders". In Gene Silencing: Theory, Techniques and Applications, 81-110. Nova Science Publishers, 2013.
    Published
  3. Faneca, Henrique; Cardoso, Ana Luísa; Trabulo, Sara; Duarte, Sónia; de Lima, Maria C. Pedroso. "Cationic Liposome-Based Systems for Nucleic Acid Delivery: From the Formulation Development to Therapeutic Applications". In Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment, 153-184. Springer Netherlands, 2013.
    10.1007/978-94-007-6010-3_6
Conference abstract
  1. C Henriques, M Lopes, P Albuquerque, D Rufino?Ramos, L Gaspar, D Lobo, A C Silva, R Baganha, S Duarte; C Maguire, M Santana, L Pereira de Almeida, R J Nobre. "P087 Production and isolation of natural and biologically active exo-AAvs for brain gene delivery". Paper presented in ESGCT 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11–14, Edinburgh, 2022.
    Published • http://doi.org/10.1089/hum.2022.29225.abstracts
  2. A C Silva, D D Lobo, C Henriques, I M Martins, S M Lopes, S P Duarte; E Wagner, R J Nobre, L Pereira de Almeida. "P214 Silencing of mutant ATXN3 through antisense oligonucleotides rescues molecular and neuropathological features in Machado-Joseph disease mice". Paper presented in European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, Edinburgh, 2022.
    Published • http://doi.org/10.1089/hum.2022.29225.abstracts
  3. B Serra, S P Duarte, N Cartier, S Alves, L P de Almeida, R Perfeito. "P221 Systemic delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of Machado-Joseph disease: a promising therapeutic strategy". Paper presented in European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, Edinburgh, 2022.
    Published • http://doi.org/10.1089/hum.2022.29225.abstracts
  4. Carlos A. Matos; Frederico Pena; Andre Conceicao; Sara Lopes; Sónia Duarte; et al.. "CRISPR-Cas9-Mediated Pre-Transcriptional Silencing of Mutant ATXN3 Decreases Motor Impairments of an In Vivo Machado-Joseph Disease Model. MOLECULAR THERAPY (2019) 27 (4): 120-121". Paper presented in 22nd Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT), Washington, DC, USA, 2019, 2019.
    Published
  5. Catarina Oliveira Miranda; Adriana Marcelo; Teresa Pereira Silva; Joao Barata; Ana Vasconcelos-Ferreira; Dina Pereira; Sónia Duarte; et al.. "Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy, In European Journal of Clinical Investigation (2019) 49 (S1): 44-44". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), May 22-24, 2019, Coimbra, Portugal., 2019.
    Published • 10.1111/eci.13109
  6. C Matos; F Pena; A Conceicao; Lopes S.; Duarte, S.P; et al.. "CRISPR interference-mediated silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model, In European Journal of Clinical Investigation (2019) 49 (S1): 86-87". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), May 22-24, 2019, Coimbra, Portugal., 2019.
    Published • 10.1111/eci.13109
  7. Duarte, Sónia; Beatriz Estremores; Janete Cunha-Santos; Miranda, Catarina; João Barata; AR La Spada; Pereira de Almeida, Luis. "Let-7 microRNA overexpression mediated by lentivirus alleviates neuropathology, balance and motor deficits in Machado-Joseph disease mouse models, HUMAN GENE THERAPY (2018) 29 (12), A81-A81". Paper presented in 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland, 2018.
    Published • 10.1089/hum.2018.29077.abstracts
  8. CO Miranda; A Marcelo; TP Silva; J Barata; A Vasconcelos-Ferreira; D Pereira; S Duarte; et al.. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease/spinocerebellar ataxia type-3, HUMAN GENE THERAPY (2018) 29 (12), A56-A56". Paper presented in 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland, 2018.
    Published • 10.1089/hum.2018.29077.abstracts
  9. L Mendonça; D Henriques; R Moreira; Sónia Duarte; JC Schwamborn; L Pereira de Almeida. "Generation and transplantation of patient-specific iPSC-derived neuroepithelial stem cells for Machado-Joseph disease treatment, HUMAN GENE THERAPY (2018) 29 (12), A66-A66". Paper presented in 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland, 2018.
    Published • 10.1089/hum.2018.29077.abstracts
  10. Duarte, S.; de Almeida LP; La Spada, A.R.. "Unravelling let-7 role in Machado-Joseph Disease, In Human Gene Therapy (2016) 27 (11), A1-A185". Paper presented in XXIVth Annual Congress of European Society of Gene and cell Therapy, October 18-21, 2016, Florence, Italy, 2016.
    Published • 10.1089/hum.2016.29035.abstracts
  11. Duarte, S.; Faneca, H.; Pedroso de Lima, M.C.. "Development of folate-lipid-based systems for tumour-targeted gene delivery, In Ejc Supplements (2010) 8 (5): 72-72". Paper presented in 21st Meeting of the European Association for Cancer Research, June 26-29, 2010, Oslo, Norway., 2010.
    Published • 10.1016/s1359-6349(10)71079-x
  12. Trabulo, S.; Mano, M; Faneca, H.; Cardoso, A.L.; Duarte, S.; Gomes, P.; Simões, S.; Pedroso De Lima, M.C.. "Association of S4 (13)-PV cell penetrating peptide with cationic liposomes: A synergistic effect on the intracellular delivery of plasmid DNA, In Journal of Peptide Science (2008) 14 (8), 135-135". Paper presented in 30th European Peptide Symposium (30EPS), August 31-September 5, 2008, Helsinki, Finland, 2008.
    Published • 10.1002/psc.1090
  13. Duarte, S.; Faneca, H.; Trabulo, S.; Cardoso, A.L.; Pedroso de Lima, M.C.. "Folate-associated cationic liposomes as a promising system for tumor-targeted gene delivery, Human Gene Therapy (2008) 19 (10): 1153". Paper presented in XVIth European Society of Gene and Cell Therapy Meeting, November 12-16, 2008, Bruges, Belgium, 2008.
    Published • 10.1089/hum.2008.1034
  14. Duarte, Sónia; Fortes, António G.; Prazeres, Duarte. M.; Marcos, João C.. "Integration of plasmid DNA purification and molecular therapy agent preparation using aqueous two-phase systems, In Journal of Biotechnology (2007) 131 (2): S6". Paper presented in 13th European Congress on Biotechnology, September 16-19, 2007, Barcelona, Spain, 2007.
    Published • 10.1016/j.jbiotec.2007.07.012
Conference poster
  1. A C Silva, C Henriques, D D Lobo, A R Fernandes, M Lopes, D Pereira,; S P Duarte, R Baganha, S M Lopes, M Santana, R J Nobre L Pereira de Almeida. "Allele-specific silencing of mutant ATXN3 rescues motordeficits and neuropathology in a severely impaired mouse model of spinocerebellar ataxia type 3 (SCA3) upon intra-cisterna magna administration". Paper presented in 30th ESGCT meeting, 24th-27th October 2023, 2023.
  2. Silva, Patrick; Santana, Magda M; Pinto, Maria; Gaspar, Laetitia S; Nobre, Rui Jorge; Duarte, Sónia; Monteiro Marques, Tania; et al. "Discrimitating spinocerebellar ataxia type 3 ataxic mutation carriers from control and pre-ataxic throuh miRNA expression profiles in plasma-derived extracellular vesicles". Paper presented in EMBO|EMBL Symposium: The non-coding genome, 2023.
  3. Silva, Ana Carolina; Henriques, Carina; Lobo, Diana Duarte; Pereira, Dina; Duarte, Sónia; Lopes, Sara Monteiro; Lopes, Miguel Monteiro; et al. "Investigating routes of administration and AAV serotypes for development of a gene-based therapy for spinocerebellar ataxia type 3 (SCA3)". Paper presented in ESGCT 30th Congress, 2023.
  4. Santos, Bárbara; Afonso, Mariana; Alves, André; Amaral, Sandra; Candeias, Emanuel,; Cardoso, Maria; Cortes, Luísa; Cruz, Teresa; Da Silva, Jéssica; Duarte, Sónia P., et al.. "GreenLabsCIBB - One path for sustainable research". Paper presented in Green Labs Portugal Symposium: Promoting sustainability in Research, 2023.
  5. Mendes, Cândida; Marques, Carla; Mota, Sandra I.; Afonso, Mariana; Alves, André; Amaral, Sandra; Candeias, Emanuel; Cardoso, Maria; Cortes, Luísa; Cruz, Teresa; Da Silva, Jéssica; Duarte, Sónia P. et al.. ""Collection Points"-Reuse and Recycling". Paper presented in Green Labs Portugal Symposium: Promoting sustainability in Research, 2023.
  6. Alarico, S., Afonso M., Alves A., Amaral S., Amorim R., Candeias E., Cardoso M., Cortes L., Cruz T., Duarte S.P., Faria ; Gonçalves M., Lavoura N., Léger H., Manadas B., Marques C., Marques C.I., Mele M., Mendes C., Miranda C., Mota S.I., Rib; Romera L., Roxo I. , Santos B., Santiago A.R., Santos D., Sebastião A.I., Simões I.. "GreenLabsCiBB | One path for sustainable research". Paper presented in Envisioning the research centres of the future | EU-LIFE, June 2023, Gulbenkian, 2023.
  7. Carina Henriques, Miguel Lopes, Patricia Albuquerque, David Rufino-Ramos, Laetitia Gaspar, Diana Lobo, Ana Carolina Silv; Sónia Duarte, Casey A. Maguire, Magda Santana, Luis Pereira de Almeida*, Rui Jorge Nobre*. "ISOLATION OF NATURAL AND BIOLOGICALLY ACTIVE EV-AAVs FOR BRAIN GENE DELIVERY". Paper presented in American Society of Gene & Cell Therapy (ASGCT), 26th Annual Meeting, May 16-20, 2023 | Los Angeles, CA, 2023.
  8. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Martins, Inês; Duarte, Sónia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Miranda, Catarina. Corresponding author: Miranda, Catarina. "Mesenchymal Stromal Cell Therapeutic Potential to Restore Blood-Brain Barrier Integrity in Machado-Joseph Disease". Paper presented in FENS Regional Meeting 2023 (FRM), 2023.
  9. Serra, Beatriz; Duarte, Sónia; Françoise, PIGUET; Nathalie Cartier; Alves, Sandro; de Almeida, Luis Pereira; Perfeito, Rita. "Validation of the brain-targeting AAV- PHP.eB encoding cholesterol hydroxylase CYP46A1: a promising non-invasive therapeutic strategy for Spinocerebellar Ataxia Type 3". Paper presented in FENS Regional Meeting 2023, 2023.
  10. Beatriz Guedes, Sónia Duarte, Sandra Morais Cardoso, Ana Raquel Esteves. "Unmasking miRNA 486-5p role in Parkinson's disease: inflammation in the spotlight". Paper presented in AD/PD 2023 International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders. 28 March-1 April, Gothenburg, Sweden., 2023.
  11. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Nobre, Rui Jorge; Martins, Inês; Silva, António; Duarte, Sónia; Pereira de Almeida, L; Miranda, Catarina Oliveira. "Altered Tight Junction-Associated Proteins Subcellular Localization in Machado-Joseph Disease/Spinocerebellar Ataxia Type 3.". Paper presented in 26ª Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH), 2022.
  12. D Santos, MI Santos, R Baganha, RJ Nobre, M Figiel, ; L Pereira de Almeida, ; and SP Duarte. Corresponding author: and SP Duarte. "P231 MicroRNAs as cornerstones in Machado-Joseph disease pathogenesis: Development of a microRNA-based gene therapy". Paper presented in European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, 2022.
  13. C Henriques, M Lopes, P Albuquerque, D Rufino-Ramos, L Gaspar, D Lobo, A C Silva, ; R Baganha, S Duarte, C Maguire, M Santana, L Pereira de Almeida, R J Nobre. "P087 Production and isolation of natural and biologically active exo-AAvs for brain gene delivery". Paper presented in European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, 2022.
  14. A C Silva, D D Lobo, C Henriques, I M Martins, S M Lopes, S P Duarte,; E Wagner, R J Nobre, L Pereira de Almeida. "P214 Silencing of mutant ATXN3 through antisense oligonucleotides rescues molecular and neuropathological features in Machado-Joseph disease mice". Paper presented in European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, 2022.
  15. B Serra, S P Duarte, N Cartier, S Alves, L P de Almeida, R Perfeito. "P221 Systemic delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of Machado-Joseph disease: a promising therapeutic strategy". Paper presented in European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, 2022.
  16. Diana Santos, Maria Inês Santos, Rafael Baganha, Rui Jorge Nobre; Maciej Figiel, Luís Pereira de Almeida; Sónia Patrícia Duarte (Presenter). Corresponding author: Sónia Patrícia Duarte (Presenter). "Investigating microRNA dysregulation towards the development of a microRNA-based therapy for Spinocerebellar ataxia type-3|Machado-Joseph disease (SCA3|MJD)". Paper presented in CONGRESSO SPDMOV (Sociedade Portuguesa das Doenças do Movimento) 2022, April 1, 2, 2022.
  17. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Martins, Inês; Silva, António; Duarte, Sónia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Miranda, Catarina Oliveira. Corresponding author: Miranda, Catarina Oliveira. "Unravelling Mesenchymal Stromal Cells Potential for Alleviation of Blood-Brain Barrier Disruption in Machado-Joseph Disease". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022.
  18. Maria Inês Barros, António da Silva, Inês Martins, Sónia Duarte, Rui Jorge Nobre, Ana Teresa Simões, ; Luís Pereira de Almeida* and Catarina Oliveira Miranda*. "Therapeutic effects of Mesenchymal Stromal Cells Secretome in Machado-Joseph Disease Models". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021.
  19. Sandra O. Braz, Catarina Vinhas, Daniel Henriques, Ricardo Moreira, Rosário Faro, Sónia Duarte, ; Luis Pereira de Almeida and Liliana S. Mendonça. "Cerebellar transplantation of iPSC-derived neuroepithelial stem cells silenced for mutant ATXN3 for Machado-Joseph disease". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021.
  20. Diana Santos, Maria Inês Santos, Rafael Baganha, Rui Jorge Nobre, Luis Pereira de Almeida* ; Sónia P. Duarte*. Corresponding author: Sónia P. Duarte*. "Restoration of dysregulated microRNA levels in a transgenic mouse model of Machado-Joseph disease as a novel therapeutic approach". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021.
  21. Maria Inês Santos, Ana Daniela Oliveira, Maria M. Pinto, Magda M. Santana, Diana Santos, Ana Rita Álvaro,; Luís Pereira de Almeida* ; Sónia P. Duarte*. Corresponding author: Sónia P. Duarte*. "miRNA dysregulation in Machado-Joseph disease: what can we learn from human induced pluripotent stem cell-based models?". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021.
  22. Beatriz Serra; Sónia P. Duarte; Nathalie Cartier; Sandro Alves; Luís Pereira de Almeida; Rita Perfeito. "Intravenous delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of spinocerebellar ataxia type 3: a promising non- invasive therapeutic strategy". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021.
  23. Ana Carolina Silva, Diana D. Lobo, Carina Henriques, Inês M. Martins, Sara M. Lopes, Sónia P. Duarte, Elizabeth Wagner,; Rui Jorge Nobre* and Lui´s Pereira de Almeida*; *Equal contribution. "Antisense oligonucleotide mediated allele-specific silencing of mutant ATXN3 improves disease features in mouse models of Machado-Joseph disease". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021.
  24. Silva, Ana Carolina; Lobo, Diana Duarte; Henriques, Carina; Martins, Maria Inês; Lopes, Sara Monteiro; Duarte, Sónia Patrícia; Wagner, E; Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. "Allele-specific silencing of Machado-Joseph disease using antisense oligonucleotide therapeutics". Paper presented in 1st Symposium on Oligonucleotide Technologies and Therapeutics@Portugal, 2021.
  25. Sónia Patrícia Duarte, Beatriz Estremores, Janete Cunha-Santos, Catarina Oliveira Miranda, João Barata, Diana Santos,; Maciej Figiel, Albert La Spada, Luis Pereira de Almeida. "MicroRNA profiling in Spinocerebellar ataxia type-3: On the development of a miRNA-based therapy". Paper presented in NAF's biennial Ataxia Investigators Meeting (AIM 2020)---Postponed to May 24-27, 2021, virtual AIM due to COVID pandemics, 2021.
  26. Mendonça Liliana; Daniel Henriques; Vanessa Fernandes; Ricardo Moreira; Ana C. Vinhas; Rosário Faro; Sónia Duarte; et al.. ""Patient specific IPSC-derived neuroepithelial stem cells for cell-based therapy in Machado-Joseph disease"". Paper presented in FENS 2020 Virtual Forum (accepted for electronic poster presentation), July 11-15, 2020, 2020.
  27. Lodewilk Toonen, Raygene Martier, Rui Nobre, Astrid Valles, Janice Stricker-Shaver,; Jeannette Hübener-Schmid, Sonia Duarte, et al.. "Assessment of the Novel AAV-Based miQURE Gene Therapy in SCA3 Animal Models". Paper presented in ASGCT 23rd Annual meeting, 2020.
  28. Henriques C; Lopes, M; Albuquerque PR; Rufino-Ramos D; Gaspar L; Lobo D; Duarte S; et al. "Extracellular vesicles-associated AAVs as new gene delivery vectors for the treatment of brain disorders". Paper presented in 3rd BEB Day (2019), 2019.
  29. Barros MI; Martins Inês; Duarte, S.P.; Nobre RJ; Simões AT; Miranda CO; Pereira de Almeida L. "Assessing the putative role of mesenchymal stromal cells effectors in Machado-Joseph disease". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences (Coimbra, Portugal), 2019, 2019.
  30. Ricardo Moreira; Liliana S. Mendonça; Daniel Henriques; Sónia Duarte; et al.. ""Investigation of Mutant Ataxin-3 spreading in Machado-Joseph Disease"". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences (Coimbra, Portugal), 2019, 2019.
  31. Henriques C; Lopes, M; Albuquerque PR; Rufino-Ramos D; Gaspar L; Lobo D; Duarte S; et al. "Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases". Paper presented in 5th GEIVEX Symposium, November 6-8, 2019, 2019.
  32. Carlos A. Matos; André Conceição; Frederico Pena; Sara Lopes; Duarte, Sónia; Catarina Miranda; Luis Pereira de Almeida. "TRANSCRIPTIONAL REPRESSION OF MUTANT HUMAN ATNX3 USING CRISPR INTERFERENCE MITIGATES THE PATHOLOGICAL PHENOTYPE OF AN IN VIVO MACHADO-JOSEPH DISEASE MODEL". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), May 30-June 1, 2019, Lisbon, Portugal., 2019.
  33. Liliana S. Mendonça; Ricardo Moreira; Daniel Henriques; Duarte, Sónia; Teresa Rodrigues; Henrique Girão; Jens C. Schwamborn; Luis Pereira de Almeida. "INVESTIGATION OF MUTANT ATAXIN-3 SPREADING IN MACHADO-JOSEPH DISEASE". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), May 30-June 1, 2019, Lisbon, Portugal., 2019.
  34. Catarina Oliveira Miranda; Adriana Marcelo; Teresa P. Silva; Joao Barata; Ana Vasconcelos-Ferreira; Dina Pereira; Duarte S; et al.. "Sustainable phenotypic ameliorations in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells and can be monitored through proton Magnetic Resonance Spectroscopy biomarkers". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), May 30-June 1, 2019, Lisbon, Portugal., 2019.
  35. Sónia Patrícia Duarte, Beatriz Estremores, Janete Cunha-Santos, Catarina Miranda, João Barata, Albert La Spada, ; Luis Pereira de Almeida. "Upregulation of let-7 microrna in mouse models of Machado-Joseph disease ameliorates neuropathology and motor phenotype". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), May 22-24, 2019, Coimbra, Portugal., 2019.
  36. Miranda CO; Adriana Machado; Silva Teresa P; Barata, J.; Vasconcelos-Ferreira A; Pereira, Dina; Duarte S; et al.. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease and Its Efficacy Can Be Monitored With Neurospectroscopic Biomarkers". Paper presented in 1st international symposium Secretome With]Out[ Borders, December 6 - 7th, 2018, 2018.
  37. Duarte, Sónia; B Estremores, J Cunha-Santos, C O Miranda, J Barata, A R La Spada, L P de Almeida. "Let-7 microRNA overexpression mediated by lentivirus alleviates neuropathology, balance and motor deficits in Machado-joseph disease mouse models". Paper presented in 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland., 2018.
  38. Miranda CO, Machado A, Silva T, Barata J, Vasconcelos-Ferreira A, Pereira D, Duarte S, Nóbrega C; Sereno J, Peretrella L, Paiva V, Castelhano J, Nobre R, Gomes C, Castelo-Branco M and de Almeida LP. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3". Paper presented in 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland., 2018.
  39. L Mendonça, D Henriques, R Moreira, S Duarte, JC Schwamborn and L Pereira de Almeida. "Generation and transplantation of patient-specific iPSC-derived neuroepithelial stem cells for Machado-Joseph disease treatment". Paper presented in 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland., 2018.
  40. Miranda C.O., Machado A., Silva T., Barata J., Pereira D., Vasconcelos-Ferreira A., Nóbrega C., Peretrella L.; Sereno J., Castelhano J., Duarte S., Nobre R., Paiva V., Castelo-Branco M. and de Almeida L.P.. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3 through neuroprotection of GABAergic neurons". Paper presented in 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), October 12-14, 2017, Covilhã, Portugal., 2017.
  41. Duarte, Sónia; Miranda, C.O., Cunha-Santos, J., Barata, J., Estremores, B., La Spada, A.R., de Almeida, L.P.. "Let-7 activates autophagy and alleviates motor and neuropathological deficits in pre- and post-symptomatic Machado-Joseph disease mouse models". Paper presented in International Ataxia Research Conference, September 27-30, 2017, Pisa, Italy., 2017.
  42. Miranda C.O., Machado A., Silva T., Barata J., Nóbrega C., Duarte S.; Nobre R., Sereno J., Paiva V., Castelhano J., Castelo-Branco M. and de Almeida L.P. "Repeated systemic injection of mesenchymal stem cells sustainably alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease". Paper presented in XV Meeting of the Portuguese Society for Neuroscience, May 25-26, 2017, Braga, Portugal., 2017.
  43. Duarte, Sónia; Catarina Oliveira Miranda, Janete Cunha-Santos, João Barata, Albert R. La Spada, Luís Pereira de Almeida. "Autophagy activation mediated by let-7 alleviates motor and neuropathological deficits in pre- and post-symptomatic Machado-Joseph disease mouse models". Paper presented in XV Meeting of the Portuguese Society for Neuroscience, May 25-26, 2017, Braga, Portugal., 2017.
  44. Duarte, Sónia; La Spada A.R., de Almeida L.P.. "Unravelling let-7 role in Machado-Joseph Disease". Paper presented in XXIVth Annual Congress of European Society of Gene and cell Therapy, October 18-21, 2016, Florence, Italy, 2016.
  45. Magda M Santana; Nóbrega, Clévio David Rodrigues ; Nobre, Rui Jorge; Miranda, Catarina; Sousa-Ferreira, Ligia; Simões, Ana Teresa; Duarte, Sónia; et al. "Gene therapy approaches to investigate pathogenesis and disease modifying strategies for neurodegenerative diseases". Paper presented in Showcasing Portuguese Pharma Science:Advances in Discovery, Development and Manufacturing. Hovione and MIT Portugal Pharma Science Symposium, 2014.
  46. Duarte, Sónia; Faneca H. and Pedroso de Lima M.C.. "A novel folate-associated lipoplex formulation for gene delivery: evaluation of the potential for HSV-tk/valganciclovir suicide gene therapy in vitro and in vivo". Paper presented in XX Porto cancer meeting, April 28-29, 2011, Porto, Portugal., 2011.
  47. Duarte, Sónia; Faneca H. and Pedroso de Lima M.C.. "Development of folate-lipid-based systems for tumor-targeted gene delivery". Paper presented in 21st Meeting of the European Association for Cancer Research, June 26-29, 2010, Oslo, Norway., 2010.
  48. Duarte, Sónia; Faneca H., Trabulo S., Cardoso A.L. and Pedroso de Lima M.C.. "Folate-associated cationic liposomes as a promising system for tumor-targeted gene delivery". Paper presented in XVIth European Society of Gene and Cell Therapy Meeting, November 12-16, 2008, Bruges, Belgium., 2008.
  49. Trabulo S., Mano M., Faneca H., Cardoso A.L., Duarte S., Gomes P., Simões S., de Lima M.C.. "Association of S413-PV cell penetrating peptide with cationic liposomes: a synergistic effect on the intracellular delivery of plasmid DNA". Paper presented in 30th European Peptide Symposium (30EPS), August 31-September 5, 2008, Helsinki, Finland., 2008.
  50. Trabulo S., Mano M., Faneca H., Cardoso A.L., Duarte S., Simões S., Pedroso de Lima M.C. "S4(13)-PV cell penetrating peptide-based systems for the intracellular delivery of plasmid DNS and siRNA". Paper presented in V Encontro anual do CNC, December 20-21, 2007, Coimbra, Portugal., 2007.
  51. Duarte S., Marcos J.C.. "Quantification of plasmid DNA in the presence of PEGylated polyethyleneimine by hydrophobic interaction chromatography". Paper presented in 5º Encontro Nacional de Cromatografia, December 10-12, 2007, Aveiro, 2007.
  52. Trabulo S., Mano M., Faneca H., Cardoso A.L., Duarte S., Simões S., de Lima M.C.. "Enhancement of the intracellular delivery of siRNA and plasmid DNA using S4(13)-PV cell penetrating peptide-based systems". Paper presented in 2nd Intracellular Delivery of Therapeutic Molecules – From Concept to Application, September 19-21, 2007, Grenoble, France., 2007.
  53. Duarte, Sónia; Fortes A.G., Prazeres D.M.F., Marcos J.C.. "Integration of plasmid DNA purification and molecular therapy agent preparation using aqueous two-phase systems". Paper presented in 13th European Congress on Biotechnology, September 16-19, 2007, Barcelona, Spain., 2007.
  54. Duarte, Sónia; Barbosa H., Prazeres D.M.F. and Marcos J.C.. "Isolation of DNA Plasmid from Polyethyleneimine Polyplexes in Aqueous Two-Phase Systems". Paper presented in International Conference on Biopartitioning and Purification (BPP 2005), June 20-24, 2005, Netherlands., 2005.
Journal article
  1. Mendonça, Liliana S.; Henriques, Daniel; Fernandes, Vanessa; Moreira, Ricardo; Brás, João; Duarte, Sónia; Schwamborn, Jens C.; de Almeida, Luís Pereira. "Graft-derived neurons and bystander effects are maintained for six months after human iPSC-derived NESC transplantation in mice’s cerebella". Scientific Reports 14 1 (2024): http://dx.doi.org/10.1038/s41598-024-53542-x.
    Published • 10.1038/s41598-024-53542-x
  2. Nobre, Rui Jorge; Lobo, Diana D.; Henriques, Carina; Duarte, Sonia P.; Lopes, Sara M.; Silva, Ana C.; Lopes, Miguel M.; et al. "miRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3". Nucleic Acid Therapeutics 32 3 (2022): 194-205. http://dx.doi.org/10.1089/nat.2021.0020.
    10.1089/nat.2021.0020
  3. Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif et al.. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy (2021): https://www.tandfonline.com/doi/citedby/10.1080/15548627.2020.1797280?scroll=top&needAccess=true.
    Published • 10.1080/15548627.2020.1797280
  4. Silva, Ana C; Lobo, Diana D; Martins, Inês M; Lopes, Sara M; Henriques, Carina; Duarte, Sónia P; Dodart, Jean-Cosme; Nobre, Rui Jorge; Pereira de Almeida, Luis. "Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders". Brain 143 2 (2019): 407-429. http://dx.doi.org/10.1093/brain/awz328.
    Open access • Published • 10.1093/brain/awz328
  5. Oliveira Miranda, C.; Marcelo, A.; Silva, T.P.; Barata, J.; Vasconcelos-Ferreira, A.; Pereira, D.; Nóbrega, C.; et al. "Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease". Molecular Therapy 26 9 (2018): 2131-2151. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050950218&partnerID=MN8TOARS.
    Published • 10.1016/j.ymthe.2018.07.007
  6. Dubinsky, A.N.; Dastidar, S.G.; Hsu, C.L.; Zahra, R.; Djakovic, S.N.; Duarte, S.; Esau, C.C.; et al. "Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy". Cell Metabolism 20 4 (2014): 626-638. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907967415&partnerID=MN8TOARS.
    Published • 10.1016/j.cmet.2014.09.001
  7. Duarte, S.; Momier, D.; Baqué, P.; Casanova, V.; Loubat, A.; Samson, M.; Guigonis, J.-M.; et al. "Preventive cancer stem cell-based vaccination reduces liver metastasis development in a rat colon carcinoma syngeneic model". Stem Cells 31 3 (2013): 423-432. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874818661&partnerID=MN8TOARS.
    Published • 10.1002/stem.1292
  8. Duarte, S.; Carle, G.; Faneca, H.; Lima, M.C.P.D.; Pierrefite-Carle, V.. "Suicide gene therapy in cancer: Where do we stand now?". Cancer Letters 324 2 (2012): 160-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864392111&partnerID=MN8TOARS.
    Published • 10.1016/j.canlet.2012.05.023
  9. Duarte, S.; Loubat, A.; Momier, D.; Topi, M.; Faneca, H.; Pedroso De Lima, M.C.; Carle, G.F.; Pierrefite-Carle, V.. "Isolation of head and neck squamous carcinoma cancer stem-like cells in a syngeneic mouse model and analysis of hypoxia effect". Oncology Reports 28 3 (2012): 1057-1062. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865312688&partnerID=MN8TOARS.
    Published • 10.3892/or.2012.1904
  10. Duarte, S.; Faneca, H.; Lima, M.C.P.D.. "Folate-associated lipoplexes mediate efficient gene delivery and potent antitumoral activity in vitro and in vivo". International Journal of Pharmaceutics 423 2 (2012): 365-377. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856552664&partnerID=MN8TOARS.
    Published • 10.1016/j.ijpharm.2011.12.035
  11. Duarte, S.; Faneca, H.; Pedroso De Lima, M.C.. "Non-covalent association of folate to lipoplexes: A promising strategy to improve gene delivery in the presence of serum". Journal of Controlled Release 149 3 (2011): 264-272. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951941675&partnerID=MN8TOARS.
    Published • 10.1016/j.jconrel.2010.10.032
  12. Trabulo, Sara; Mano, Miguel; Faneca, Henrique; Cardoso, Ana Luísa; Duarte, Sónia; Henriques, Ana; Paiva, Artur; et al. "S413-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA". The Journal of Gene Medicine 10 11 (2008): 1210-1222. http://dx.doi.org/10.1002/jgm.1247.
    Published • 10.1002/jgm.1247
  13. Duarte, S.P.; Fortes, A.G.; Prazeres, D.M.F.; Marcos, J.C.. "Preparation of plasmid DNA polyplexes from alkaline lysates by a two-step aqueous two-phase extraction process". Journal of Chromatography A 1164 1-2 (2007): 105-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548030710&partnerID=MN8TOARS.
    Published • 10.1016/j.chroma.2007.06.061
Newspaper article
  1. Ana Catarina Vinhas; Ana Cristina Ferreira; Carina Henriques; Carolina Silva; et al.. "DOENÇAS RARAS: Uma viagem rara - Cartoon created on purpose for the Journal "THE PUBLIC" to explain a rare disease that affects many Portuguese, Machado-Joseph disease.", Público, 2020, https://www.publico.pt/2020/02/28/ciencia/fotogaleria/viagem-rara-400481.
Thesis / Dissertation
  1. Duarte, Sónia. "ON THE DEVELOPMENT OF ANTITUMOURAL THERAPEUTIC STRATEGIES: Suicide gene therapy mediated by lipid-based systems and cancer stem cell-based vaccination". PhD, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2012. http://hdl.handle.net/10316/20480.
  2. Duarte, Sónia. "Validação de uma técnica de HPLC para determinação de anti-inflamatórios do grupo do Etofenamato". Degree, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2004.

Other

Other output
  1. MicroRNA profiling in human cell-based models of Machado-Joseph disease. 2020. Maria Inês Santos, Sónia Patrícia Duarte. http://hdl.handle.net/10316/92999.
  2. The role of autophagy activation-mediated by Let-7 in a transgenic mouse model of Machado-Joseph Disease. 2018. Estremores, Beatriz; Duarte, Sónia Patricia. http://hdl.handle.net/10316/86233.