Henrique Matos Fernandes de Oliveira Duarte (CE14-D4A9-61C8)

Curriculum Vitae

Henrique Matos Fernandes de Oliveira Duarte

Henrique O. Duarte has an international PhD in Molecular and Cellular Biotechnology Applied to Health Sciences (ICBAS/FFUP, University of Porto, 2020), funded by FCT and the European Association for Cancer Research (EACR). Host Institution: Glycobiology in Cancer group of the Institute for Research and Innovation in Health, University of Porto (i3S) and the Center for Proteomics and Metabolomics of the Leiden University Medical Center (CPM/LUMC), Leiden, The Netherlands. During his PhD, Henrique has comprehensively dissected the glycosylation profile of the ErbB2 oncogenic receptor in gastric cancer and identified glycan-mediated pathways of molecular resistance to the clinically implemented trastuzumab therapeutic agent. Using translational multidisciplinary approaches, including genetically glycoengineered tumor cell models and mass spectrometry-guided workflows for glycan structural elucidation, his research work has provided clinically relevant insights on the mechanistic role played by glycans on ErbB2-positive advanced gastric cancer. Henrique's PhD research work has been acknowledged, funded and awarded by multiple renowned Institutions of Biomedical and Cancer Research (including the European Society for Medical Oncology (ESMO), The European Molecular Biology Laboratory (EMBL), the European Association for Cancer Research (EACR), the International Glycoconjugate Organization (IGO), the Utrecht University, and Portuguese Society for Human Genetics). Currently: Junior Researcher and Project Leader at i3S, where he is dissecting the role played by cancer-associated glycosylation signatures in the emergence of molecular resistance to both conventional and targeted therapies in the advanced gastric cancer setting. His work has selected for presentation in multiple international scientific meetings related to Cancer Biology, and has been awarded as both the poster and oral communication (including the Porto Cancer Meeting). He has co-authored 16 publications in internationally recognized peer-reviewed journals (including high profile publications in Trends in Cancer, Oncogene, Cancer Cell, Molecular Aspects of Medicine, FEBS Letters, Plant Biotechnology journal), and 3 book chapters edited by prestigious scientific publishers (Nova Publishers, Wiley and Elsevier). He has secured funding as PI in two competitive calls: 3rd edition "Prémio Francisco Augusto da Fonseca Dias e Maria José Melenas da Fonseca para Jovens Investigadores" (LOGIC 2021, 50.000€), and an FCT-funded project (EMERGENCE 2022.04138.PTDC, 50.000€). He served as Co-PI of an FCT-funded project (GlycOrganoid 2021, 50.000€), and has integrated the teams of multiple FCT- and pharmaceutical industry-funded projects (~1.5M€). He currently manages a team composed by one Research Trainee, one MSc student, and he co-supervises one MSc student. He has integrated the organizing and scientific committees of national and international scientific meetings (including the IV BiotechHealth Annual Symposium (Porto, 2017), EU-funded COST Action Young Researchers Meeting (Iasi, 2023) and the 15th Jenner Glycobiology and Medicine Symposium (Porto, 2023)). He serves as a reviewer for high impact scientific journals (Nature Comumnications, Molecular Oncology, Oncotarget, American Journal of Cell Physiology, Cancers, iScience). Previous studies: Integrated Master in Bioengineering, with a specialization in Molecular Biotechnology (2014, FEUP/ICBAS) awarded by the University of Porto, for which he was awarded with a Merit Scholarship for Exceptional Achievement as a student of the University of Porto by the Portuguese Ministry of Education (3rd best student of the 2009-2014 class). Research intern at the Department of Infectious Diseases of the National Health Institute (2012). Research intern at the Structural Biology Department of the Vrije University Amsterdam, The Netherlands (ERASMUS international mobility programme, 2013).

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Identification

Personal identification

Full name: Henrique Matos Fernandes de Oliveira Duarte

Citation names

Duarte, Henrique O.

Author identifiers

Ciência ID: CE14-D4A9-61C8
ORCID iD: 0000-0001-8641-8368
Google Scholar ID: https://scholar.google.com/citations?user=N8wMNcYAAAAJ&hl=en&oi=ao
Researcher Id: rid75594
Scopus Author Id: 57193257827

Email addresses

hduarte@ipatimup.pt (Professional)

Telephones

Telephone

(+351) 22 607 490 Ext.: 6067 (Professional)

Addresses

Rua Alfredo Allen 208, 4200-235, Porto, Porto, Portugal (Professional)

Websites

https://www.i3s.up.pt/content/people?id=1107&idg=26 (Professional)
https://www.linkedin.com/in/henrique-oliveira-duarte-a52446202/ (Professional)

Knowledge fields

Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)

Education

	Degree	Classification
2020/09/21 Concluded	Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (Doutoramento) Major in Sem especialidade Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "Cracking the ErbB2 Sugar Code in Gastric Cancer: A Bitter Sweet Functional Target " (THESIS/DISSERTATION)	NA
2018/09/16 - 2018/09/21 Concluded	Genome Engineering: CRISPR / Cas (Curso de Especialização Tecnológica) EMBL Heidelberg Genomics Core Facility, Germany
2017/07/17 - 2017/07/21 Concluded	Utrecht Summer School - Molecular Mechanisms in Cancer (Curso de Especialização Tecnológica) Hubrecht Institute, Netherlands Universiteit Utrecht Faculteit Geneeskunde, Netherlands
2016/09 - 2016/09 Concluded	FELASA C (Federation of European Laboratory Animal Science ASsociations) training in Laboratory Animal Science (Curso de Especialização Tecnológica) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014/07/14 Concluded	Bioengenharia (Mestrado) Major in Área de especialização: Biotecnologia Molecular Universidade do Porto Faculdade de Engenharia, Portugal "Exploiting the interplay between c.-Myc and novel micrornas in prostate carcinogenesis" (THESIS/DISSERTATION)	18.06 (out of 20)

Affiliation

Science

	Category Host institution	Employer
2021/06/01 - Current	Principal Investigator (Research)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

2020/09/22 - 2021/05/31	Postdoc (Research)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/01/01 - 2015/12/31	Research Trainee (Research)	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Others

	Category Host institution	Employer
2016/01/01 - 2020/09/21	PhD Student (enrolled in the BiotechHealth International PhD Programme)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2013/09/15 - 2014/09/15	Master Student	Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
	Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2013/02/01 - 2013/07/31	Research Intern (curricular internship within the Integrated Master in Bioengineering)	Vrije Universiteit Amsterdam, Netherlands
	Vrije Universiteit Amsterdam, Netherlands
2012/01/01 - 2012/12/31	Research Intern (curricular internship within the Integrated Master in Bioengineering)	Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
	Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Projects

Grant

	Designation	Funders
2024/01/01 - Current	GLYCO_BRIDGE: Bridging skills in glycosciences to leap forward cancer glycobiology knowledge 2023.09792.CBM Institut de Biologie Structurale, France Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Campus France Ongoing
2020/06/01 - Current	Norway-Portugal European Economic Agreement (EEA) ---- Invited Scientist Fellow Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Oslo universitetssykehus, Norway	EEA Grants Ongoing
2023/02/01 - 2024/07/31	EMERGENCE - ErbB2 Molecular Heterogeneity Drives Glycan-Mediated Trastuzumab Resistance 2022.04138.PTDC 10.54499/2022.04138.PTDC Principal investigator Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2016/05/01 - 2019/12/31	Glycosylation of Tyrosine Kinase Receptors as Novel Biomarkers for Targeted Therapy NORTE-01-0145-FEDER-000029 PhD Student Fellow Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Comissao de Coordenacao e Desenvolvimento Regional do Norte Concluded
2016/03/01 - 2018/02/28	Glycosylation of Tyrosine Kinase Receptors in Gastric Cancer: Novel Biomarkers for Targeted Therapy 441.00 DAAD PhD Student Fellow Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Deutscher Akademischer Austauschdienst Concluded
2015/10/01 - 2015/12/31	Glycosylation of Cellular Receptors in Cancer ------ Integration into Research Grant Fellow Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Merck KGaA Concluded
2013/06/01 - 2015/09	Zinc-finger nuclease-glycoengineered SimpleCell lines for characterization of the O-glycoproteome of cancer cells. PTDC/BBB-EBI/0786/2012 Integration into Research Grant Fellow Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/04/01 - 2014/07/31	Discovery of novel microRNA genes epigenetically down-regulated in prostate cancer EXPL/BIM-ONC/0556/2012 Master Student Fellow Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2022/01/01 - Current	LOGIC - Glycoform-Specific Detection of ErbB2 in Gastric Cancer: Improving Patient Stratification and Redefining Eligibility for Anti-ErbB2 Targeted Therapy ----- Principal investigator Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Universidade do Porto Instituto de Patologia e Imunologia Molecular Ongoing
2023/02/01 - 2029/01/31	CHOICE - Cracking tHe erbb2 sugar cOde In CancEr: towards prognostic and therapeutic stratificationCracking the ErbB2 Sugar Code in Cancer: Towards Prognostic and Therapeutic Stratification 2022.00943.CEECIND/CP1735/CT0017 10.54499/2022.00943.CEECIND/CP1735/CT0017 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/01/01 - 2024/12/31	GLYCOTARGET. A NEW FRONTIER IN EXTRACELLULAR VESICLE-MEDIATED CANCER IMMUNOMODULATION<br> PTDC/MEC-ONC/0491/2021 10.54499/PTDC/MEC-ONC/0491/2021 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal Instituto de Astrofísica e Ciências do Espaço, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/01/01 - 2024/12/31	SweetKiller: Monosaccharide analogues as novel therapeutic agents to block glycan-driven cancer cell metastasis. PTDC/MED-QUI/2335/2021 10.54499/PTDC/MED-QUI/2335/2021 Instituto de Astrofísica e Ciências do Espaço, Portugal FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/01/01 - 2023/12/31	Glycan-defined organoids as gastric cancer avatars for patient stratification and prediction of therapeutic response EXPL/BTM-ORG/1450/2021 10.54499/EXPL/BTM-ORG/1450/2021 Co-Principal Investigator (Co-PI) Instituto de Astrofísica e Ciências do Espaço, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016/07/01 - 2020/03/31	CELLULAR GLYCOENGINEERING FOR EVALUATION OF POST-TRANSLATIONAL MODIFICATIONS OF RECEPTORS IN CANCER: THERAGNOSTIC APPLICATIONS PTDC/BBB-EBI/0567/2014 Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Instituto de Investigação e Inovação em Saúde UID/BIM/04293/2019 Instituto Nacional de Engenharia Biomédica, Portugal Universidade do Porto, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Instituto de Astrofísica e Ciências do Espaço, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2017/01/01 - 2019/12/31	Glyco Tech: Using glycoengineered Cell Lines as Biotechnological Tools to Unravel Resistance Mechanisms in Cancer Therapy PD/BD/128407/2017 Instituto de Investigaciones Biomédicas Sols-Morreale, Spain	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter	Magalhães, Ana; Duarte, Henrique O.; Reis, Celso A.. "Glycans and Cancer". In Encyclopedia of Cell Biology, 373-384. Amsterdam, Netherlands: Elsevier, 2023. 10.1016/b978-0-12-821618-7.00019-5 Duarte, Henrique O.. "Targeting Carbohydrates in Cancer: Analytical and Biotechnological Tools". In Carbohydrate-based Therapeutics and Diagnostics, edited by Luigi Lay; Roberto Adamo. Hoboken, United States: WILEY-VCH GmbH, 2022. Published Duarte, Henrique O.. "Glycans as Gastrointestinal Cancer Biomarkers: Old and New Diagnostic, Predictive and Stratifying Tools". In Glycome: The Hidden Code in Biology, 231-246. New York, United States: Nova Science Publishers, 2021. Published
Conference poster	Ribeiro, Ana Raquel; Marques, Catarina; Gomes, Catarina; Faria-Ramos, Isabel; Reis, Celso A.; Duarte, Henrique O.; Magalhães, Ana. "Compreender o impacto da glicosilação com Heparano Sulfato na modulação da atividade de Recetores Tirosina Cinase em cancro". Paper presented in ENJIO - 5º Encontro Nacional de Jovens Investigadores em Oncologia, 2023. Duarte, Henrique O.. "ST6Gal1 Targets the ErbB2 Ectodomain in a Site-Specific Manner and Regulates Gastric Cancer Cell Sensitivity to Trastuzumab". Paper presented in EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine, 2022. Duarte, Henrique O.. "a2,6-Linked Sialic Acid Regulates ErbB2 Biology and Gastric Cancer Cell Response to Trastuzumab in a Glycosite-Specific Manner". Paper presented in 25th Symposium on Glycoconjugates, 2019. Duarte, Henrique O.. "Unravelling ErbB2 Glycosylation Signature in Gastric Cancer Cells". Paper presented in 29th International Carbohydrate Symposium, 2018. Duarte, Henrique O.. "Deciphering ErbB2 Glycosylation Profile in Gastric Cancer Cells". Paper presented in 2nd edition of the practical course - From Protein Structure to Biological Function through Interactomics: An Integrated View, 2018. Duarte, Henrique O.. "Phosphorylation of the Estrogen Receptor Alpha in Breast Cancer: The Hunt for the Elusive Kinase". Paper presented in 10th edition of the Young European Scientist (YES) Meeting, 2015.
Journal article	Duarte, Henrique O.. "Patient-derived organoids to study glycosylation dynamics during gastric disease". Biorxiv (2025): https://www.biorxiv.org/content/10.1101/2025.02.21.639100v1. Open access • Published • 10.1101/2025.02.21.639100 Duarte, Henrique O.. Corresponding author: Duarte, Henrique O.. "HER2 and PD-L1 Expression in Gastric and Gastroesophageal Junction Cancer: Insights for Combinatorial Targeting Approaches". Cancers 16 6 (2024): 1227. https://www.mdpi.com/2072-6694/16/6/1227. Open access • Published • 10.3390/cancers16061227 Izadi, Shiva; Gumpelmair, Simon; Coelho, Pedro; Duarte, Henrique O.; Gomes, Joana; Leitner, Judith; Kunnummel, Vinny; et al. "Plant-derived Durvalumab variants show efficient PD-1/PD-L1 blockade and therapeutically favourable FcR binding". Plant Biotechnology Journal (2023): https://onlinelibrary.wiley.com/doi/10.1111/pbi.14260. Open access • Published • 10.1111/pbi.14260 Costa-Barbosa, Augusto; Ferreira, Diogo; Pacheco, Maria Inês; Casal, Margarida; Duarte, Henrique Oliveira; Gomes, Catarina; Barbosa, Ana Margarida; et al. "Candida albicans chitinase 3 with potential as a vaccine antigen: Production, purification and characterisation". Biotechnology Journal (2023): 2300219. https://onlinelibrary.wiley.com/doi/full/10.1002/biot.202300219. Open access • Published • 10.1002/biot.202300219 Duarte, Henrique O.; Reis, Celso A.; Gomes, Joana. "Insights on ErbB glycosylation – contributions to precision oncology". Trends in Cancer (2022): https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00039-5. 10.1016/j.trecan.2022.02.003 Francisca Diniz; Pedro Coelho; Henrique O. Duarte; Bruno Sarmento; Celso A. Reis; Joana Gomes. "Glycans as Targets for Drug Delivery in Cancer". Cancers (2022): https://doi.org/10.3390/cancers14040911. 10.3390/cancers14040911 Abrantes, Rafaela; Duarte, Henrique O.; Gomes, Catarina; Wälchli, Sébastien; Reis, Celso A.. "CAR-Ts: New Perspectives in Cancer Therapy". FEBS Letters 596 4 (2022): 403-416. https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14270. Open access • Published • 10.1002/1873-3468.14270 Magalhães, Ana; Duarte, Henrique O.; Reis, Celso A.. "The role of O-glycosylation in human disease". Molecular Aspects of Medicine 79 (2021): 100964. https://www.sciencedirect.com/science/article/abs/pii/S0098299721000248#:~:text=O%2Dglycans%20are%20key%20modulators,pathogen%20interplay%20and%20immune%20response.&text=Aberrant%20cellular%20O%2Dglycosylation%20promotes%20oncogenic%20signaling%20and%20tu. Published • 10.1016/j.mam.2021.100964 Duarte, Henrique O.; Rodrigues, Joana G.; Gomes, Catarina; Hensbergen, Paul J.; Ederveen, Agnes L. Hipgrave; de Ru, Arnoud H.; Mereiter, Stefan; et al. "ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab". Oncogene 40 21 (2021): 3719-3733. https://www.nature.com/articles/s41388-021-01801-w. Published • 10.1038/s41388-021-01801-w Rodrigues, Joana G.; Duarte, Henrique O.; Gomes, Catarina; Balmaña, Meritxell; Martins, Álvaro M.; Hensbergen, Paul J.; de Ru, Arnoud H.; et al. "Terminal a2,6-sialylation of epidermal growth factor receptor modulates antibody therapy response of colorectal cancer cells". Cellular Oncology 44 4 (2021): 835-850. https://link.springer.com/article/10.1007%2Fs13402-021-00606-z. Open access • Published • 10.1007/s13402-021-00606-z Rodrigues, Joana G.; Duarte, Henrique O.; Reis, Celso A.; Gomes, Joana. "Aberrant protein glycosylation in cancer: implications in targeted therapy". Biochemical Society Transactions 49 2 (2021): 843-854. https://portlandpress.com/biochemsoctrans/article-abstract/49/2/843/228064/Aberrant-protein-glycosylation-in-cancer?redirectedFrom=fulltext. Published • 10.1042/bst20200763 Leão, Beatriz; Wen, Xiaogang; Duarte, Henrique O.; Gullo, Irene; Gonçalves, Gilza; Pontes, Patrícia; Castelli, Claudia; et al. "Expression of Thomsen–Friedenreich Antigen in Colorectal Cancer and Association with Microsatellite Instability". International Journal of Molecular Sciences 22 3 (2021): 1340. https://www.mdpi.com/1422-0067/22/3/1340. Open access • Published • 10.3390/ijms22031340 Duarte, Henrique O.; Gomes, Joana; Machado, José C.; Reis, Celso A.. "Gastric cancer: Basic aspects". Helicobacter 23 (2018): e12523. https://onlinelibrary.wiley.com/doi/epdf/10.1111/hel.12523. Published • 10.1111/hel.12523 Duarte, H.O.; Balmaña, M.; Mereiter, S.; Osório, H.; Polónia, A.; Santos, L.L.; Gomes, J.; Reis, C.A.. "PO-174 ErbB2 glycosylation landscape in gastric cancer cells: a novel functional target?". ESMO Open 3 (2018): A295. https://www.esmoopen.com/article/S2059-7029(20)31742-7/fulltext#relatedArticles. Open access • Published • 10.1136/esmoopen-2018-eacr25.696 Barros-Silva D; Costa-Pinheiro P; Duarte H; Sousa EJ; Evangelista AF; Graça I; Carneiro I; et al. "MicroRNA-27a-5p regulation by promoter methylation and MYC signaling in prostate carcinogenesis.". Cell death & disease 9 167 (2018): https://www.nature.com/articles/s41419-017-0241-y. Open access • Published • 10.1038/s41419-017-0241-y Duarte, H.O.; Balmaña, M.; Mereiter, S.; Osório, H.; Gomes, J.; Reis, C.A.. "Gastric cancer cell glycosylation as a modulator of the ErbB2 oncogenic receptor". International Journal of Molecular Sciences 18 11 (2017): 2262-2280. https://www.mdpi.com/1422-0067/18/11/2262. Open access • Published • 10.3390/ijms18112262 Magalhães, Ana; Duarte, Henrique O.; Reis, Celso A.. "Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis". Cancer Cell 31 6 (2017): 733-735. https://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30208-8. Open access • Published • 10.1016/j.ccell.2017.05.012 Duarte, H.O.; Freitas, D.; Gomes, C.; Gomes, J.; Magalhães, A.; Reis, C.A.. "Mucin-type O-glycosylation in gastric carcinogenesis". Biomolecules 6(3) 33 (2016): E33. https://www.mdpi.com/2218-273X/6/3/33. Open access • Published • 10.3390/biom6030033
Preprint	Costa, Ana F.; Senra, Emanuel; Campos, Diana; Faria-Ramos, Isabel; Santos-Ferreira, Liliana; Lamas, Sofia; Gomes, Joana; et al. "Monensin as potential drug for treatment of SLeX-positive tumors". 2024. http://dx.doi.org/10.1101/2024.03.11.24304048. 10.1101/2024.03.11.24304048
Thesis / Dissertation	"Cracking the ErbB2 Sugar Code in Gastric Cancer: A Bitter Sweet Functional Target". PhD, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2021. https://repositorio-aberto.up.pt/handle/10216/129345. Duarte, Henrique O.. "Exploiting the Interplay between c-Myc and Novel MicroRNAs in Prostate Carcinogenesis". Master, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2014. https://sigarra.up.pt/reitoria/en/pub_geral.pub_view?pi_pub_base_id=31436.

Intellectual property

Provisional application for patent

2021. "ErbB2 site-specific alpha2,6-sialylation as a biomarker of gastric cancer cell sensitivity to trastuzumab".
Protected

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2024/01/17	ErbB2 Glycosylation in Gastric Cancer: Unravelling the Bittersweet Road to Molecular Resistance	7th Iberian Carbohydrate Meeting Real Sociedad Española de Química (RSEQ) and Sociedade Portuguesa de Química (SPQ) (Sitges, Spain)
2023/10	ErbB2 Glycosylation in Gastric Cancer: Unraveling the Bittersweet Road to Molecular Resistance	10th Anniversary of the BiotechHealth International Doctoral Program Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (ICBAS) (Porto, Portugal)
2023/06/15	ST6Gal1 Modifies ErbB2 Trastuzumab-Binding Domain in a Site-Specific Manner to Support Molecular Resistance to Trastuzumab	15th Jenner Glycobiology and Medicine Symposium Royal Society of Medicine; Institute for Research and Innovation in Health, University of Porto (i3S) (Porto, Portugal)
2023/05/11	Cracking the ErbB2 Sugar Code in Gastric Cancer – A Bittersweet Functional Target.	29th Porto Cancer Meeting – Glycosylation in Tumor Biology and Its Clinical Implications: The Cancer Bittersweet Portrait Institute for Research and Innovation in Health, University of Porto (i3S) (Porto, Portugal)
2023/04/21	ST6Gal1 Modifies ErbB2 Trastuzumab-Binding Domain in a Site-Specific Manner to Support Molecular Resistance to Trastuzumab	International Meeting of Young Researchers 2023 - Sour Turned Sweet: Glycans Bridging Technology and Precision Medicine COST Actions 18103 INNOGLY and 18132 GLYCONanoPROBES (Ia¿i, Romania)
2022/11/19	ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab	26th Annual Meeting of the Portuguese Society of Human Genetics (SPGH) Sociedade Portuguesa de Genética Humana (SPGH) (Coimbra, Portugal)
2021/10/14	Cracking the ErbB2 Sugar Code in Gastric Cancer - A Bitter Sweet Functional Target	II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer ASPIC-ASEICA
2021/09/27	Cracking the ErbB2 Sugar Code in Gastric Cancer - A Bitter Sweet Functional Target	INNOGLY-ECI-WG3-2021: Young Glyco-Scientists on stage INNOGLY
2019/11/28	Cracking the ErbB2 Sugar Code in Gastric Cancer - A Novel Biomarker for the Prediction of Trastuzumab Therapeutic Response	Institute for Research and Innovation in Health (i3S) Annual Meeting Institute for Research and Innovation in Health (i3S), University of Porto (Póvoa de Varzim, Portugal)
2019/09/03	Unraveling the ErbB2 Glycan Repertoire in Gastric Cancer - A Bitter Sweet Functional Target	13th International Meeting of the Portuguese Carbohydrate Group – GLUPOR 13 Sociedade Portuguesa de Química (Porto, Portugal)
2019/05/02	Cracking the ErbB2 Sugar Code in Gastric Cancer - A Bitter Sweet Functional Target	26th Porto Cancer Meeting – The Cancer Ecosystem: from Research to Pathology & Treatment. Institute for Research and Innovation in Health (Porto, Portugal)
2018/11/30	ErbB2 Glycosylation in Gastric Cancer – A Bitter Sweet Functional Target	Institute for Research and Innovation in Health (i3S) Annual Meeting Institute for Research and Innovation in Health (i3S), University of Porto (Póvoa de Varzim, Portugal)
2018/07/14	Unravelling ErbB2 Glycosylation Signature in Gastric Cancer Cells	29th International Carbohydrate Symposium International Carbohydrate Organization (Lisboa, Portugal)
2018/05/30	Glycosylation Landscape in Gastric Cancer Cells – A Novel Functional Target?	1st PhDay at i3S – From Bench to Stage, From Desk to Forum Institute for Research and Innovation in Health (i3S), University of Porto (Porto, Portugal)
2017/09/11	Deciphering ErbB2 Glycosylation Profile in Gastric Cancer Cells	12ª Reunião do Grupo de Glúcidos - GLUPOR12 Sociedade Portuguesa de Química (Aveiro, Portugal)
2015/05/14	Phosphorylation of the Estrogen Receptor Alpha in Breast Cancer: The Hunt for the Elusive Kinase	8th edition of the Meeting of Young Researchers of the University of Porto (IJUP) University of Porto (Porto, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023/09/01 - 2024/11/11	Combining Mass Spectrometry Analytical Workflows and Automated Image Analysis to Uncover the Spatial Heterogeneity of Tumor-Associated Glycan Networks in Gastric Cancer Supervisor of Rodrigo Gregório Samico	Master's Degree in Bioinformatics and Computational Biology (Master) Universidade do Porto Faculdade de Ciências, Portugal
2023/01/01 - 2024/06/06	Unravelling the impact of Heparan Sulfate profiles in Receptor Tyrosine Kinase activation using gastric cancer as model Co-supervisor	Master's Degree in Medicine and Molecular Oncology (Master) Universidade do Porto Faculdade de Medicina, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/04/01 - 2023/09/15	EMERGENCE - ErbB2 Molecular Heterogeneity Drives Glycan-Mediated Trastuzumab Resistance Supervisor	Research Fellowship (Other) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/02/01 - 2023/07/31	Unraveling the ErbB2 Glycome in Gastric Cancer - Functional and Clinical Impact Supervisor of Ângela Faria	Project/Internship (Degree) Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2025/02/03 - 2025/02/03	Round Table "Encontramo-nos no fim: à procura de resposta", XX Jornadas de Engenharia Biomédica da Universidade do Minho. Round table	XX Jornadas de Engenharia Biomédica da Universidade do Minho Universidade do Minho, Portugal

Association member

	Society Organization name	Role
2022/10/20 - Current	European Cooperation in Science and Technology (COST)	Affiliated member
2017/03/14 - Current	European Association for Cancer Research	Affiliated member
2017/03/14 - Current	Associação Portuguesa de Investigação em Cancro (ASPIC)	Affiliated member

Committee member

	Activity description Role	Institution / Organization
2023/06/14 - 2023/06/16	15th Jenner Glycobiology and Medicine Symposium - Organizing Committee Member	The Royal Society of Medicine, United Kingdom Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Conference scientific committee

	Conference name	Conference host
2023/04/20 - 2023/04/21	International Meeting of Young Researchers 2023 - Sour Turned Sweet: Glycans Bridging Technology and Precision Medicine	COST Actions 18103 INNOGLY and 18132 GLYCONanoPROBES
2017/07/03 - 2017/07/04	IV BiotechHealth Annual Symposium - Spotting the differences: Biotechnology driving precision medicine	Institute for Research and Innovation in Health (i3S), University of Porto

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2023/08/22 - 2023/09/12	Dutch Research Council (NWO) Round Open Competition Domain Science Package 22-6 - Evaluation of Scientific Project Applications. Evaluator	Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Netherlands	Nederlandse Organisatie voor Wetenschappelijk Onderzoek
2022/04 - 2022/04	Croatia-China Scientific and Technological Cooperation Call for Project Proposals for R&D Projects. Evaluator		Department of International Cooperation Hrvatska zaklada za znanost

Mentoring / Tutoring

	Topic	Student name
2024/09/10 - 2024/11/30	Scientific Supervision of Visiting PhD Student Secondment - Jhenifer Santos dos Reis	Jhenifer Santos dos Reis
2023/02/01 - 2023/05/31	Scientific supervision of the PhD student Kristína Kianicková, from the Slovak Academy of Sciences, in the context of the National Scholarship Program from the Slovak Republic.	Kristína Kianicková
2022/09/01 - 2022/10/15	Scientific supervision of the PhD student Kristína Kianicková, from the Slovak Academy of Sciences, in the context of the COST Action CA18103	Kristína Kianicková
2022/04/01 - 2022/04/30	Scientific supervision of the MSc student Catarina Costa in the curricular unit Laboratorial Rotation of the Master in Biomedical Research of the University of Coimbra.	Catarina Costa
2021/10/01 - 2022/02/28	Scientific Mentoring - Integrated Master in Bioengineering (University of Porto), Project in Molecular Bioengineering	André Oliveira; Filipa Ferreira; Francisco Ferreira; Inês Faria; José Maria Costa
2021/10/01 - 2022/02/28	Curricular Unit Project in Biomedical Engineering of the Integrated Master in Bioengineering (FEUP/ICBAS)	Inês Faria; André Oliveira; Filipa Ferreira; Francisca Ferreira; José Maria Costa.
2020/01/14 - 2020/01/14	Invited speaker at Semana das Profissões of Colégio Nossa Senhora do Rosário, in the Health Sciences panel	Several
2016/06/27 - 2016/07/01	Mentor of the Ciência Viva educational program, organized by the Agência Nacional para a Cultura Científica e Tecnológica	Several
2015/03/21 - 2015/03/21	Invited speaker at the III AEICBAS Biomedical Congress	Several
2015/03/12 - 2015/03/15	Ipatimup representative at Mostra de Ciência, Ensino e Educação da Universidade do Porto	Several

Other jury / evaluation

	Activity description	Institution / Organization
2025/02/25 - 2025/02/25	Call for a Junior Researcher within the project: Addressing Malnutrition and Metabolic Health in Non-Communicable Diseases Through Precision Nutrition: Impact in Quality of Life and Prognosis of Lung Cancer Patients (HORIZON-EIC-2023PATHFINDERCHALLENGES-GA 101162297), member of the jury.	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024/12/01 - 2024/12/01	Call for a Research Technician within the FCT-funded project SweetKiller: Monosaccharide Analogues as Novel Therapeutic Agents to Block Glycan-Driven Cancer Cell Metastasis (PTDC/MED-QUI/2335/2021), alternate member of the jury.	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/06/14 - 2023/06/16	15th Jenner Glycobiology and Medicine Symposium. Royal Society of Medicine and i3S, Porto, Portugal. Evaluation of poster presentations.	The Royal Society of Medicine, United Kingdom Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/03/01 - 2023/03/01	Call for a Research Fellow (BI-M) within the FCT-funded project MGL4Life - Targeting Human Macrophage Galactose C-type Lectin Towards the Development of Innovative and Alternative Cancer Therapies (PTDC/QUI-OUT/2586/2020), member of the jury.	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/03/01 - 2023/03/01	Call for a Research Fellow (BI-M) within the FCT-funded project EMERGENCE – ErbB2 Molecular Heterogeneity Drives Glycan-Mediated Trastuzumab Resistance (2022.04138.PTDC), President of the jury.	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/02/23 - 2023/02/24	9th McBiology Symposium – Science: Everything, Everywhere All at Once. i3S, Porto, Portugal. Evaluation of oral communications.	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/07/01 - 2022/07/01	Call for a Junior Researcher holding a PhD degree within the FCT-funded project SweetKiller: Monosaccharide Analogues as Novel Therapeutic Agents to Block Glycan-Driven Cancer Cell Metastasis (PTDC/MED-QUI/2335/2021), member of the jury.	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/11/30 - 2021/11/30	4th PhDay at i3S – Break Borders, Build Opportunities. i3S, Porto, Portugal. Evaluation of oral communications and poster presentations.	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Distinctions

Award

2023	26th Annual Meeting of the Portuguese Society of Human Genetics (SPGH) – SPGH Annual Award for Best Scientific Paper Sociedade Portuguesa de Genética Humana, Portugal
2022	Travel and Registration Grant awarded by the European Association for Cancer Research, at the EACR 2022 Congress - Innovative Cancer Science: Translatin Biology to Medicine European Association For Cancer Research, United Kingdom
2021	Prémio Francisco Augusto da Fonseca Dias e Maria José Melenas da Fonseca para Jovens Investigadores Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2019	Travel and Registration Grant for the 25th International Symposium on Glycoconjugates
2019	Best Speed Talk Presentation at the 26th Porto Cancer Meeting - The Cancer Ecosystem: from Research to Pathology & Treatment
2019	Winner of the 1st edition of the i3S (Institute for Research and Innovation in Health) Fundraising Travel Grant Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019	EACR Travel Fellowship European Association For Cancer Research, United Kingdom
2018	Travel and Registration Grant for the practical course Genome Engineering: CRISPR / Cas organized by the European Molecular Biology Laboratory (EMBL) Boehringer Ingelheim Auslandsbeteiligungs GmbH, Germany
2018	Travel and Registration Grant awarded by the European Association for Cancer Research, at the EACR25 – 25th Biennal Congress of the European Association for Cancer Research European Association For Cancer Research, United Kingdom
2018	Best Poster Presentation and Travel Grant at the practical course “From Protein Structure to Biological Function through an Interactomics: An Integrated View
2018	Merit Scholarship for Exceptional Achievement as a student of the Faculty of Engineering of the University of Porto (2009/2010-2013/2014), attributed by the Directorate General of Higher Education and the Ministry of Education of the Portuguese government Governo da República Portuguesa, Portugal
2016	Travel and Registration Grant awarded by the European Society for Medical Oncology, at the ESMO Symposium on Signalling Pathways in Cancer 2016 European Society for Medical Oncology, Switzerland
2015	Oncology and Molecular Biology Poster Presentation First Prize for the work Phosphorylation of the Estrogen Receptor Alpha in Breast Cancer: The Hunt for the Elusive Kinase, at the 10th edition of the Young European Scientist (YES) Meeting

Other distinction

2022	FEBS Letters Issue Cover Illustration Federation of European Biochemical Societies, United Kingdom