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Maria José Umbelino Ferreira is Full Professor of Medicinal Chemistry at Faculty of Pharmacy, University of Lisbon, where she is currently the Coordinator of the Master in Medicinal and Biopharmaceutical Chemistry. She was the head of the Department of Pharmaceutical Chemistry from 2018 -2020. MJU Ferreira has published more than 130 indexed peer-reviewed papers/book chapters (Scopus: h-index 37; Google Scholar: h-index 43) and supervised/co-supervised 44 PhD/MSc students and postdoctoral fellows. She is the President of the Phytochemical Society of Europe since May 2024 and was the Vice -president(2022-2024) and the Regional Representative of the same Society for Iberia (2016-2020). She leads the research group of Natural Products Chemistry at Research Institute for Medicines (IMed.ULisboa), Faculty of Pharmacy, University of Lisbon (https://imed.ulisboa.pt/labs/maria-jose-ferreira/). She is co-founder the startup Beat Therapeutics, which main goal is to develop an anticancer drug candidate for personalized therapy. MJU Ferreira is currently member of COST Action CA17104 and she was member COST Action CM1407, COST Action BM0701 and member of management committee of COST Action B16-Multidrug Resistance Reversal. She is currently member of the Editorial board of Molecules (MDPI), Plants (MDPI) and Phytochemical Analyses (WILEY). Moreover, she was also guest editor of Frontiers in Pharmacology (Frontiers) and Phytochemistry Reviews (Springer) and International Journal of Molecular Sciences (MDPI). Having background in Organic and Medicinal Chemistry and advanced spectroscopic techniques, Maria José main research interest is the isolation of new bioactive chemical scaffolds from plant sources and molecular derivatization of selected compounds, using hemi-synthetic methodologies. Her main goal is to discover anticancer compounds for targeting multidrug-resistant cancer cells, namely ABC-transporter modulators.
Identification

Personal identification

Full name
Maria José Umbelino Ferreira

Citation names

  • Maria-José U. Ferreira

Author identifiers

Ciência ID
CE1A-3108-AC3C
ORCID iD
0000-0002-8742-1486
Researcher Id
M-8053-2013
Scopus Author Id
7402787141

Email addresses

  • mjuferreira@ff.ulisboa.pt (Professional)

Telephones

Telephone
  • (+351) 217946475 (Professional)

Addresses

  • Faculdade de Farmácia, Universidade de Lisboa. Av. Prof. Gama Pinto, 1649-003 , Lisboa, Lisboa, Portugal (Professional)

Websites

Education
Degree Classification
2007
Concluded
Química Farmacêutica (Título de Agregado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
Unanimidade (maximal classification)
1986 - 1990
Concluded
Farmácia (Doutoramento)
Major in Química Farmacêutica
Universidade de Lisboa Faculdade de Farmácia, Portugal
"-" (THESIS/DISSERTATION)
Distinção e louvor/Very Good (maximal class.)
Affiliation

Teaching in Higher Education

Category
Host institution
Employer
2023/07/01 - Current Full Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal

Positions / Appointments

Category
Host institution
Employer
2019/11 - Current Coordinator of the Master of Science in Medicinal and Biopharmaceutical Chemistry Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/01/12 - Current Group Leader- Natural Products Chemistry Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2007/09/01 - 2023/06 Associate Professor with Habilitation Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2022 Coordinator of the Second Cycles of Study at FFULisboa Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/09/07 - 2020/12 Head of the Pharmaceutical and Medicinal Chemistry Department Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/05/31 - 2020/09 Representative of Portugal and Spain in the Directive Board of the Phytochemical Society of Europe (PSE) Phytochemical Society of Europe, United Kingdom
2008/01/01 - 2019 Coordinator of the Master of Science in Pharmaceutical and Medicinal Chemistry Universidade de Lisboa Faculdade de Farmácia, Portugal
Outputs

Publications

Book chapter
  1. Duarte, Noélia; Ramalhete, Cátia; Rijo, Patrícia; Reis, Mariana Alves; Ferreira, Maria-José U.. "Stilbenoids in Grapes and Wine". In Handbook of Dietary Phytochemicals, 1005-1032. Springer Singapore, 2021.
    10.1007/978-981-15-4148-3_21
  2. Maria-José. U. Ferreira; Madureira, A.M.. Corresponding author: Maria-José. U. Ferreira. "Caffeine extraction from tea and coffee". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. United Kingdom: Royal Society of Chemistry, 2017.
    Published
  3. Zachariah, T. J.; Parthasarathy, V. A.. "Isolation and structural identification of piperine, the major alkaloid of black pepper". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, 21-40. United Kingdom: Royal Society of Chemistry, 2016.
    Published • 10.1079/9781845934057.0021
  4. Maria-José U. Ferreira. "Thin layer chromatography of plants pigments.". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom.. Royal Society of Chemistry, 2016.
  5. Maria-José U. Ferreira. "Synthesis of dibenzalacetone 2,4-dinitrophenylhydrazone derivative". In Comprehensive Organic Chemistry Experiments. 2016.
  6. Smith, Tom; Chitnis, Nakul; Penny, Melissa A.. "Malária no contexto da Química Medicinal". In DOENÇAS NEGLIGENCIADAS SOB A ÓTICA DA QUÍMICA MEDICINAL, 1-7. Brazil: EDITORA CRV, 2015.
    10.1007/978-1-4614-8757-9_80-1
  7. Maria-José U. Ferreira. "Reversal of Multidrug Resistance by Macrocyclic and Polycyclic Diterpenoids from Euphorbia species". 2012.
    Published
  8. Ferreira, M.-J.U.; Duarte, N.-A.; Michalak, K.; Varga, A.; Molnár, J.. "Piceatannol, an antitumor compound from euphorbia lagascae seeds". Elsevier, 2011.
    10.1016/B978-0-12-375688-6.10054-4
Conference paper
  1. Maria-José U. Ferreira. "SEARCHING FOR NATURAL ANTITUBERCULARS FROM MOZAMBICAN MEDICINAL PLANTS". Paper presented in Congresso Internacional Saber Tropical em Moçambique: História, Memória e Ciência Instituto de Investigação Cientifica Tropical- IICT – JBT/Jardim Botânico Tropical. Lisboa, 24-26 outubro de 2012, 2012.
  2. Maria-José U. Ferreira. "Antimalarial Activity of Some Plants Traditionally used in Mozambique". Paper presented in Workshop Plantas medicinais e práticas fitoterapêuticas nos trópicos, 2009.
  3. Maria-José U. Ferreira. "Macrocyclic diterpenes as promising effective MDR modulators in cancer cells. European Conference on the Reversal of Multidrug Resistance from Bacteria to Cancer Cells and Parasites.". Paper presented in European Conference on the Reversal of Multidrug Resistance from Bacteria to Cancer Cells and Parasites. COST Action B16 Conference Proceedings., 2006.
  4. Maria-José U. Ferreira. "Study of the Acetone and Methanol Extracts of Euphorbia segetalis in Natural Products in the New Millenium: Prospects and Industrial Application". 2002.
  5. Maria-José U. Ferreira. "A Short Side Chain Cycloartane and other Triterpenes from Euphorbia tuckeyana in Natural Products in the New Millenium: Prospects and Industrial Application". 2002.
Journal article
  1. Shirley A.R. Sancha; Simona Dobiasová; Tomáš Nejedlý; Ondrej Strnad; Jitka Viktorová; Maria-José U. Ferreira. "Lycorine and homolycorine derivatives for chemo-sensitizing resistant human ovarian adenocarcinoma cells". Phytomedicine (2024): https://doi.org/10.1016/j.phymed.2024.155460.
    10.1016/j.phymed.2024.155460
  2. Joana Ribeiro; Nikoletta Szemerédib; Bruno M.F. Gonçalves; Gabriella Spengler; Carlos Alberto Mateus Afonso; Maria-José Umbelino Ferreira. "Nitrogen-containing andrographolide derivatives with multidrug resistance reversal effects in cancer cells". RSC Medicinal Chemistry (2024): http://dx.doi.org/10.1039/d3md00711a.
    10.1039/d3md00711a
  3. Maria-José U. Ferreira. "Natural Product-Derived Compounds for Targeting Multidrug Resistance in Cancer and Microorganisms". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241814321.
    10.3390/ijms241814321
  4. Cátia A. Bonito; Ricardo J. Ferreira; Maria-José U. Ferreira; Jean-Pierre Gillet; M. Natália D. S. Cordeiro; Daniel J. V. A. dos Santos. "Long-range communication between transmembrane- and nucleotide-binding domains does not depend on drug binding to mutant P-glycoprotein". Journal of Biomolecular Structure and Dynamics (2023): 1-10. http://dx.doi.org/10.1080/07391102.2023.2181633.
    10.1080/07391102.2023.2181633
  5. Shirley A. R. Sancha; Nikoletta Szemerédi; Gabriella Spengler; Maria-José U. Ferreira. "Lycorine Carbamate Derivatives for Reversing P-glycoprotein-Mediated Multidrug Resistance in Human Colon Adenocarcinoma Cells". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24032061.
    10.3390/ijms24032061
  6. Bharathiraja, P.; Cardoso, D.S.P.; Rajendra Prasad, N.; Mulhovo, S.; Lakra, D.S.; Ferreira, M.-J.U.. "Reversal of P-glycoprotein-mediated multidrug resistance by natural N-alkylated indole alkaloid derivatives in KB-ChR-8-5 drug-resistant cancer cells". Journal of Biochemical and Molecular Toxicology 37 9 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85162634507&partnerID=MN8TOARS.
    10.1002/jbt.23421
  7. Shirley A. R. Sancha; Adriana V. Gomes; Joana B. Loureiro; Lucília Saraiva; Maria José U. Ferreira. "Amaryllidaceae-Type Alkaloids from Pancratium maritimum: Apoptosis-Inducing Effect and Cell Cycle Arrest on Triple-Negative Breast Cancer Cells". Molecules (2022): https://doi.org/10.3390/molecules27185759.
    10.3390/molecules27185759
  8. Maria-José U. Ferreira. "Alkaloids in Future Drug Discovery". Molecules (2022): https://doi.org/10.3390/molecules27041347.
    10.3390/molecules27041347
  9. Cátia Ramalhete; Bruno M. F. Gonçalves; Filipa Barbosa; Noélia Duarte; Maria-José U. Ferreira. "Momordica balsamina: phytochemistry and pharmacological potential of a gifted species". Phytochemistry Reviews (2022): https://doi.org/10.1007/s11101-022-09802-7.
    10.1007/s11101-022-09802-7
  10. Deng, Z.-F.; Bakunina, I.; Yu, H.; Han, J.; Dömling, A.; Ferreira, M.-J.U.; Zhang, J.-Y.. "Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance". Frontiers in Pharmacology 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85128434911&partnerID=MN8TOARS.
    10.3389/fphar.2022.815603
  11. Silva, C.D.; Ramalhete, C.; Spengler, G.; Mulhovo, S.; Molnar, J.; Ferreira, M.-J.U.. "Triterpenes from Momordica balsamina (African pumpkin): ABCB1 inhibition and synergistic interaction with doxorubicin in resistant cancer cells". Phytochemistry 203 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85135934829&partnerID=MN8TOARS.
    10.1016/j.phytochem.2022.113354
  12. David S. P. Cardoso; Nikoletta Szemerédi; Gabriella Spengler; Silva Mulhovo; Daniel J. V. A. dos Santos; Maria-José U. Ferreira. "Exploring the Monoterpene Indole Alkaloid Scaffold for Reversing P-Glycoprotein-Mediated Multidrug Resistance in Cancer". Pharmaceuticals 14 9 (2021): 862-862. https://doi.org/10.3390/ph14090862.
    10.3390/ph14090862
  13. Rijo P; Estévez F; Sitarek P; Ferreira MU. "Editorial: "Natural Products as a Tool to Design New anti-MDR Lead Molecules."". Frontiers in pharmacology (2021): http://europepmc.org/abstract/med/34234680.
    10.3389/fphar.2021.694674
  14. Maria-José U. Ferreira. "BBIT20 inhibits homologous DNA repair with disruption of the BRCA1-BARD1 interaction in breast and ovarian cancer". British Journal of Pharmacology (2021): http://dx.doi.org/10.1111/bph.15506.
    10.1111/bph.15506
  15. Ricardo J. Ferreira; Gabriella Spengler; Andreas Orthaber; Daniel J. V. A. dos Santos; Maria-José U. Ferreira. "Pedrolane, a Polycyclic Diterpene Scaffold Containing a Bicyclo[2.2.1]heptane System, from Euphorbia pedroi". Organic Letters (2021): https://doi.org/10.1021/acs.orglett.0c03647.
    10.1021/acs.orglett.0c03647
  16. Cardoso, D.S.P.; Kincses, A.; Nové, M.; Spengler, G.; Mulhovo, S.; Aires-de-Sousa, J.; dos Santos, D.J.V.A.; Ferreira, M.-J.U.. "Alkylated monoterpene indole alkaloid derivatives as potent P-glycoprotein inhibitors in resistant cancer cells". European Journal of Medicinal Chemistry 210 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85096047821&partnerID=MN8TOARS.
    10.1016/j.ejmech.2020.112985
  17. Ferreira, M.-J.U.. "Natural products in drug discovery and human health". Phytochemistry Reviews (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85098688547&partnerID=MN8TOARS.
    10.1007/s11101-020-09736-y
  18. Ferreira, M.-J.U.. "Correction to: Natural products in drug discovery and human health (Phytochemistry Reviews, (2021), 20, 1, (1-4), 10.1007/s11101-020-09736-y)". Phytochemistry Reviews 20 1 (2021): 5-5. http://www.scopus.com/inward/record.url?eid=2-s2.0-85102046563&partnerID=MN8TOARS.
    10.1007/s11101-021-09747-3
  19. Bruno M. F. Gonçalves; David S. P. Cardoso; Maria-José U. Ferreira. "Overcoming Multidrug Resistance: Flavonoid and Terpenoid Nitrogen-Containing Derivatives as ABC Transporter Modulators". Molecules 25 15 (2020): 3364-3364. https://doi.org/10.3390/molecules25153364.
    10.3390/molecules25153364
  20. Bonito, C.A.; Ferreira, R.J.; Ferreira, M.-J.U.; Gillet, J.-P.; Cordeiro, M.N.D.S.; dos Santos, D.J.V.A.. "Theoretical insights on helix repacking as the origin of P-glycoprotein promiscuity". Scientific Reports 10 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85086600933&partnerID=MN8TOARS.
    10.1038/s41598-020-66587-5
  21. Reis, M.A.; Matos, A.M.; Duarte, N.; Ahmed, O.B.; Ferreira, R.J.; Lage, H.; Ferreira, M.-J.U.. "Epoxylathyrane Derivatives as MDR-Selective Compounds for Disabling Multidrug Resistance in Cancer". Frontiers in Pharmacology 11 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85085216314&partnerID=MN8TOARS.
    10.3389/fphar.2020.00599
  22. Ferreira, R.J.; Gajdács, M.; Kincses, A.; Spengler, G.; dos Santos, D.J.V.A.; Ferreira, M.-J.U.. "Nitrogen-containing naringenin derivatives for reversing multidrug resistance in cancer". Bioorganic and Medicinal Chemistry 28 23 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85092096903&partnerID=MN8TOARS.
    10.1016/j.bmc.2020.115798
  23. Andreia Mónico; Cátia Ramalhete; Vânia André; Gabriella Spengler; Silva Mulhovo; M. Teresa Duarte; Maria-José U. Ferreira. "Cucurbalsaminones A–C, Rearranged Triterpenoids with a 5/6/3/6/5-Fused Pentacyclic Carbon Skeleton from Momordica balsamina, as Multidrug Resistance Reversers". Journal of Natural Products (2019): https://doi.org/10.1021/acs.jnatprod.9b00019.
    10.1021/acs.jnatprod.9b00019
  24. Neto, Sara; Duarte, Noélia; Pedro, Cecília; Spengler, Gabriella; Molnár, Joséph; Ferreira, Maria-José U.. "Effective MDR reversers through phytochemical study of Euphorbia boetica". Phytochemical Analysis 30 5 (2019): 498-511. http://dx.doi.org/10.1002/pca.2841.
    10.1002/pca.2841
  25. Ferreira, Maria-José U.; Paterna, Angela. "Monoterpene indole alkaloids as leads for targeting multidrug resistant cancer cells from the African medicinal plant Tabernaemontana elegans". Phytochemistry Reviews 18 4 (2019): 971-987. http://dx.doi.org/10.1007/s11101-019-09615-1.
    Published • 10.1007/s11101-019-09615-1
  26. Ferreira, Ricardo J.; Kincses, Annamária; Gajdács, Márió; Spengler, Gabriella; dos Santos, Daniel J. V. A.; Molnár, Joseph; Ferreira, Maria-José U.. "Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers". Journal of Natural Products 81 9 (2018): 2032-2040. http://dx.doi.org/10.1021/acs.jnatprod.8b00326.
    10.1021/acs.jnatprod.8b00326
  27. Ramalhete, Cátia; Mulhovo, Silva; Lage, Hermann; Ferreira, Maria-José. "Triterpenoids from Momordica balsamina with a Collateral Sensitivity Effect for Tackling Multidrug Resistance in Cancer Cells". Planta Medica 84 18 (2018): 1372-1379. http://dx.doi.org/10.1055/a-0651-8141.
    10.1055/a-0651-8141
  28. Ferreira, Ricardo J; Baptista, Rafael; Moreno, Alexis; Madeira, Patricia G; Khonkarn, Ruttiros; Baubichon-Cortay, Hélène; dos Santos, Daniel JVA; Falson, Pierre; Ferreira, Maria-José U. "Optimizing the flavanone core toward new selective nitrogen-containing modulators of ABC transporters". Future Medicinal Chemistry 10 7 (2018): 725-741. http://dx.doi.org/10.4155/fmc-2017-0228.
    10.4155/fmc-2017-0228
  29. Kincses, Annamária; Varga, Borisz; Csonka, Ákos; Sancha, Shirley; Mulhovo, Silva; Madureira, Ana Margarida; Ferreira, Maria-José U.; Spengler, Gabriella. "Bioactive compounds from the African medicinal plant Cleistochlamys kirkii as resistance modifiers in bacteria". Phytotherapy Research 32 6 (2018): 1039-1046. http://dx.doi.org/10.1002/ptr.6042.
    10.1002/ptr.6042
  30. Paterna, A.; Khonkarn, R.; Mulhovo, S.; Moreno, A.; Madeira Girio, P.; Baubichon-Cortay, H.; Falson, P.; Ferreira, M.-J.U.. "Monoterpene indole alkaloid azine derivatives as MDR reversal agents". Bioorganic and Medicinal Chemistry 26 2 (2018): 421-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037656553&partnerID=MN8TOARS.
    10.1016/j.bmc.2017.11.052
  31. Ferreira, Ricardo J.; Bonito, Cátia A.; Ferreira, Maria José U.; dos Santos, Daniel J.V.A.. "About P-glycoprotein: a new drugable domain is emerging from structural data". Wiley Interdisciplinary Reviews: Computational Molecular Science 7 5 (2017): e1316. http://dx.doi.org/10.1002/wcms.1316.
    10.1002/wcms.1316
  32. Reis, M.A.; Ahmed, O.B.; Spengler, G.; Molnár, J.; Lage, H.; Ferreira, M.-J.U.. "Exploring Jolkinol D Derivatives to Overcome Multidrug Resistance in Cancer". Journal of Natural Products 80 5 (2017): 1411-1420. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019719063&partnerID=MN8TOARS.
    Published • 10.1021/acs.jnatprod.6b01084
  33. Paterna, A.; Kincses, A.; Spengler, G.; Mulhovo, S.; Moln�r, J.; Ferreira, M.-J.U.. "Dregamine and tabernaemontanine derivatives as ABCB1 modulators on resistant cancer cells". European Journal of Medicinal Chemistry 128 (2017): 247-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011960889&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.01.044
  34. Ferreira, R.J.; Bonito, C.A.; Cordeiro, M.N.D.S.; Ferreira, M.-J.U.; Dos Santos, D.J.V.A.. "Structure-function relationships in ABCG2: Insights from molecular dynamics simulations and molecular docking studies". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85034244902&partnerID=MN8TOARS.
    10.1038/s41598-017-15452-z
  35. Mónico, A.; Nim, S.; Duarte, N.; Rawal, M.K.; Prasad, R.; Di Pietro, A.; Ferreira, M.-J.U.. "Lathyrol and epoxylathyrol derivatives: Modulation of Cdr1p and Mdr1p drug-efflux transporters of Candida albicans in Saccharomyces cerevisiae model". Bioorganic and Medicinal Chemistry 25 13 (2017): 3278-3284. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018347859&partnerID=MN8TOARS.
    10.1016/j.bmc.2017.04.016
  36. Paterna, A.; Gomes, S.E.; Borralho, P.M.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "(3'R)-hydroxytabernaelegantine C: A bisindole alkaloid with potent apoptosis inducing activity in colon (HCT116, SW620) and liver (HepG2) cancer cells". Journal of Ethnopharmacology 194 (2016): 236-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987934442&partnerID=MN8TOARS.
    10.1016/j.jep.2016.09.020
  37. Wisniewski, J.; Wesolowska, O.; Sroda-Pomianek, K.; Paprocka, M.; Bielawska-Pohl, A.; Krawczenko, A.; Duarte, N.; et al. "Euphorbia species-derived diterpenes and coumarins as multidrug resistance modulators in human colon carcinoma cells". Anticancer Research 36 5 (2016): 2259-2264. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017889260&partnerID=MN8TOARS.
  38. Nim, S.; Mónico, A.; Rawal, M.K.; Duarte, N.; Prasad, R.; Di Pietro, A.; Ferreira, M.-J.U.. "Overcoming Multidrug Resistance in Candida albicans: Macrocyclic Diterpenes from Euphorbia Species as Potent Inhibitors of Drug Efflux Pumps". Planta Medica 82 13 (2016): 1180-1185. http://www.scopus.com/inward/record.url?eid=2-s2.0-84965006976&partnerID=MN8TOARS.
    10.1055/s-0042-106169
  39. Reis, M.A.; Ahmed, O.B.; Spengler, G.; Molnár, J.; Lage, H.; Ferreira, M.-J.U.. "Jatrophane diterpenes and cancer multidrug resistance - ABCB1 efflux modulation and selective cell death induction". Phytomedicine 23 9 (2016): 968-978. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975318127&partnerID=MN8TOARS.
    10.1016/j.phymed.2016.05.007
  40. Paterna, A.; Gomes, S.E.; Borralho, P.M.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "Vobasinyl-Iboga Alkaloids from Tabernaemontana elegans: Cell Cycle Arrest and Apoptosis-Inducing Activity in HCT116 Colon Cancer Cells". Journal of Natural Products 79 10 (2016): 2624-2634. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994056083&partnerID=MN8TOARS.
    10.1021/acs.jnatprod.6b00552
  41. Ramalhete, C.; Mulhovo, S.; Molnar, J.; Ferreira, M.-J.U.. "Triterpenoids from Momordica balsamina: Reversal of ABCB1-mediated multidrug resistance". Bioorganic and Medicinal Chemistry 24 21 (2016): 5061-5067. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991710925&partnerID=MN8TOARS.
    10.1016/j.bmc.2016.08.022
  42. Baptista, R.; Ferreira, R.J.; Dos Santos, D.J.V.A.; Fernandes, M.X.; Ferreira, M.-J.U.. "Optimizing the macrocyclic diterpenic core toward the reversal of multidrug resistance in cancer". Future Medicinal Chemistry 8 6 (2016): 629-645. http://www.scopus.com/inward/record.url?eid=2-s2.0-84966473176&partnerID=MN8TOARS.
    10.4155/fmc.16.11
  43. Pereira, F.; Madureira, A.M.; Sancha, S.; Mulhovo, S.; Luo, X.; Duarte, A.; Ferreira, M.-J.U.. "Cleistochlamys kirkii chemical constituents: Antibacterial activity and synergistic effects against resistant Staphylococcus aureus strains". Journal of Ethnopharmacology 178 (2016): 180-187. http://www.scopus.com/inward/record.url?eid=2-s2.0-84950131229&partnerID=MN8TOARS.
    10.1016/j.jep.2015.12.009
  44. Paterna, A.; Borralho, P.M.; Gomes, S.E.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "Monoterpene indole alkaloid hydrazone derivatives with apoptosis inducing activity in human HCT116 colon and HepG2 liver carcinoma cells". Bioorganic and Medicinal Chemistry Letters 25 17 (2015): 3556-3559. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938292387&partnerID=MN8TOARS.
    10.1016/j.bmcl.2015.06.084
  45. Reis, M.A.; André, V.; Duarte, M.T.; Lage, H.; Ferreira, M.-J.U.. "12,17-Cyclojatrophane and Jatrophane Constituents of Euphorbia welwitschii". Journal of Natural Products 78 11 (2015): 2684-2690. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948844292&partnerID=MN8TOARS.
    10.1021/acs.jnatprod.5b00631
  46. Ferreira, R.J.; Ferreira, M.-J.U.; Dos Santos, D.J.V.A.. "Do Drugs Have Access to the P-Glycoprotein Drug-Binding Pocket through Gates?". Journal of Chemical Theory and Computation 11 10 (2015): 4525-4529. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944233434&partnerID=MN8TOARS.
    10.1021/acs.jctc.5b00652
  47. Ferreira, R.J.; Ferreira, M.-J.U.; Dos Santos, D.J.V.A.. "Do adsorbed drugs onto P-glycoprotein influence its efflux capability?". Physical Chemistry Chemical Physics 17 34 (2015): 22023-22034. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939839565&partnerID=MN8TOARS.
    10.1039/c5cp03216d
  48. Ferreira, R.J.; Ferreira, M.-J.U.; dos Santos, D.J.V.A.. "Reversing cancer multidrug resistance: Insights into the efflux by ABC transports from in silico studies". Wiley Interdisciplinary Reviews: Computational Molecular Science 5 1 (2015): 27-55. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919463679&partnerID=MN8TOARS.
    10.1002/wcms.1196
  49. Ferreira, R.J.; Dos Santos, D.J.; Ferreira, M.-J.U.. "P-glycoprotein and membrane roles in multidrug resistance". Future Medicinal Chemistry 7 7 (2015): 929-946. http://www.scopus.com/inward/record.url?eid=2-s2.0-84931097415&partnerID=MN8TOARS.
    10.4155/fmc.15.36
  50. Cabral, V.; Luo, X.; Junqueira, E.; Costa, S.S.; Mulhovo, S.; Duarte, A.; Couto, I.; Viveiros, M.; Ferreira, M.-J.U.. "Enhancing activity of antibiotics against Staphylococcus aureus: Zanthoxylum capense constituents and derivatives". Phytomedicine 22 4 (2015): 469-476. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964270861&partnerID=MN8TOARS.
    10.1016/j.phymed.2015.02.003
  51. Matos, A.M.; Reis, M.; Duarte, N.; Spengler, G.; Molnár, J.; Ferreira, M.-J.U.. "Epoxylathyrol Derivatives: Modulation of ABCB1-Mediated Multidrug Resistance in Human Colon Adenocarcinoma and Mouse T-Lymphoma Cells". Journal of Natural Products 78 9 (2015): 2215-2228. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942693549&partnerID=MN8TOARS.
    10.1021/acs.jnatprod.5b00370
  52. Rocha E Silva, L.F.; Ramalhete, C.; Nogueira, K.L.; Mulhovo, S.; Ferreira, M.-J.U.; Pohlit, A.M.. "In vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents". European Journal of Medicinal Chemistry 102 (2015): 398-402. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939811697&partnerID=MN8TOARS.
    10.1016/j.ejmech.2015.08.022
  53. Reis, M.A.; Paterna, A.; Mónico, A.; Molnar, J.; Lage, H.; Ferreira, M.-J.U.. "Diterpenes from Euphorbia piscatoria: Synergistic interaction of lathyranes with doxorubicin on resistant cancer cells". Planta Medica 80 18 (2014): 1739-1745. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919354129&partnerID=MN8TOARS.
    10.1055/s-0034-1383244
  54. Mansoor, T.A.; Borralho, P.M.; Luo, X.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "6-Acetonyldihydrochelerythrine is a potent inducer of apoptosis in HCT116 and SW620 colon cancer cells". Journal of Natural Products 77 8 (2014): 1825-1830. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906678560&partnerID=MN8TOARS.
    10.1021/np500161n
  55. Vieira, C.; Duarte, N.; Reis, M.A.; Spengler, G.; Madureira, A.M.; Molnár, J.; Ferreira, M.-J.U.. "Improving the MDR reversal activity of 6,17-epoxylathyrane diterpenes". Bioorganic and Medicinal Chemistry 22 22 (2014): 6392-6400. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908377069&partnerID=MN8TOARS.
    10.1016/j.bmc.2014.09.041
  56. Ramalhete, C.; Da Cruz, F.P.; Mulhovo, S.; Sousa, I.J.; Fernandes, M.X.; Prudêncio, M.; Ferreira, M.-J.U.. "Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite". Bioorganic and Medicinal Chemistry 22 15 (2014): 3887-3890. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905560275&partnerID=MN8TOARS.
    10.1016/j.bmc.2014.06.019
  57. Ferreira, M.-J.U.; Duarte, N.; Reis, M.; Madureira, A.M.; Molnár, J.. "Euphorbia and Momordica metabolites for overcoming multidrug resistance". Phytochemistry Reviews (2014): 1-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894472325&partnerID=MN8TOARS.
    10.1007/s11101-014-9342-8
  58. Reis, M.A.; Paterna, A.; Ferreira, R.J.; Lage, H.; Ferreira, M.-J.U.. "Macrocyclic diterpenes resensitizing multidrug resistant phenotypes". Bioorganic and Medicinal Chemistry 22 14 (2014): 3696-3702. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902551451&partnerID=MN8TOARS.
    10.1016/j.bmc.2014.05.006
  59. Ferreira, R.J.; Ferreira, M.-J.U.; Dos Santos, D.J.V.A.. "Assessing the stabilization of P-glycoprotein's nucleotide-binding domains by the linker, using molecular dynamics". Molecular Informatics 32 5-6 (2013): 529-540. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879792902&partnerID=MN8TOARS.
    10.1002/minf.201200175
  60. Reis, M.; Ferreira, R.J.; Santos, M.M.M.; Dos Santos, D.J.V.A.; Molnár, J.; Ferreira, M.-J.U.. "Enhancing macrocyclic diterpenes as multidrug-resistance reversers: Structure-activity studies on jolkinol D derivatives". Journal of Medicinal Chemistry 56 3 (2013): 748-760. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873898843&partnerID=MN8TOARS.
    10.1021/jm301441w
  61. Ferreira, R.J.; Ferreira, M.-J.U.; Dos Santos, D.J.V.A.. "Molecular docking characterizes substrate-binding sites and efflux modulation mechanisms within P-glycoprotein.". Journal of Chemical Information and Modeling 53 7 (2013): 1747-1760. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880519085&partnerID=MN8TOARS.
    10.1021/ci400195v
  62. Mansoor, T.A.; Borralho, P.M.; Dewanjee, S.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "Monoterpene bisindole alkaloids, from the African medicinal plant Tabernaemontana elegans, induce apoptosis in HCT116 human colon carcinoma cells". Journal of Ethnopharmacology 149 2 (2013): 463-470. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883183604&partnerID=MN8TOARS.
    10.1016/j.jep.2013.06.051
  63. Sousa, I.J.; Ferreira, M.-J.U.; Molnár, J.; Fernandes, M.X.. "QSAR studies of macrocyclic diterpenes with P-glycoprotein inhibitory activity". European Journal of Pharmaceutical Sciences 48 3 (2013): 542-553. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872528917&partnerID=MN8TOARS.
    10.1016/j.ejps.2012.11.012
  64. Luo, X.; Pires, D.; Aínsa, J.A.; Gracia, B.; Duarte, N.; Mulhovo, S.; Anes, E.; Ferreira, M.-J.U.. "Zanthoxylum capense constituents with antimycobacterial activity against Mycobacterium tuberculosis in vitro and ex vivo within human macrophages". Journal of Ethnopharmacology 146 1 (2013): 417-422. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874112005&partnerID=MN8TOARS.
    10.1016/j.jep.2013.01.013
  65. Mendes, S.A.C.; Mansoor, T.A.; Rodrigues, A.; Armas, J.B.; Ferreira, M.-J.U.. "Anti-inflammatory guaiane-type sesquiterpenes from the fruits of Pittosporum undulatum". Phytochemistry 95 (2013): 308-314. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893810932&partnerID=MN8TOARS.
    10.1016/j.phytochem.2013.06.019
  66. Mansoor, T.A.; Borralho, P.M.; Luo, X.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "Apoptosis inducing activity of benzophenanthridine-type alkaloids and 2-arylbenzofuran neolignans in HCT116 colon carcinoma cells". Phytomedicine 20 10 (2013): 923-929. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879888690&partnerID=MN8TOARS.
    10.1016/j.phymed.2013.03.026
  67. Madureira, A.M.; Ramalhete, C.; Mulhovo, S.; Duarte, A.; Ferreira, M.-J.U.. "Antibacterial activity of some African medicinal plants used traditionally against infectious diseases". Pharmaceutical Biology 50 4 (2012): 481-489. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856169762&partnerID=MN8TOARS.
    10.3109/13880209.2011.615841
  68. Luo, X.; Pedro, L.; Milic, V.; Mulhovo, S.; Duarte, A.; Duarte, N.; Ferreira, M.-J.U.. "Antibacterial benzofuran neolignans and benzophenanthridine alkaloids from the roots of Zanthoxylum capense". Planta Medica 78 2 (2012): 148-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856270569&partnerID=MN8TOARS.
    10.1055/s-0031-1280289
  69. Reis, M.; Ferreira, R.J.; Serly, J.; Duarte, N.; Madureira, A.M.; Santos, D.J.V.A.; Molnár, J.; Ferreira, M.-J.U.. "Colon adenocarcinoma multidrug resistance reverted by Euphorbia diterpenes: Structure-activity relationships and pharmacophore modeling". Anti-Cancer Agents in Medicinal Chemistry 12 9 (2012): 1015-1024. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872231481&partnerID=MN8TOARS.
    10.2174/187152012803529655
  70. Mansoor, T.A.; Ramalho, R.M.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "Dibenzylbutane- and butyrolactone-type lignans as apoptosis inducers in human hepatoma HuH-7 cells". Phytotherapy Research 26 5 (2012): 692-696. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859911852&partnerID=MN8TOARS.
    10.1002/ptr.3629
  71. Ramalhete, C.; Magalhães, L.; Rodrigues, V.; Mulhovo, S.; Da Silva Filho, A.A.; Ferreira, M.-J.U.. "In vitro schistosomicidal activity of balsaminol F and karavilagenin C". Planta Medica 78 18 (2012): 1912-1917. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871621180&partnerID=MN8TOARS.
    10.1055/s-0032-1327832
  72. Ferreira, R.J.; Ferreira, M.-J.U.; Dos Santos, D.J.V.A.. "Insights on P-glycoproteins efflux mechanism obtained by molecular dynamics simulations". Journal of Chemical Theory and Computation 8 6 (2012): 1853-1864. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862203273&partnerID=MN8TOARS.
    10.1021/ct300083m
  73. Valente, I.; Reis, M.; Duarte, N.; Serly, J.; Molnár, J.; Ferreira, M.-J.U.. "Jatrophane diterpenes from euphorbia mellifera and their activity as P-glycoprotein modulators on multidrug-resistant mouse lymphoma and human colon adenocarcinoma cells". Journal of Natural Products 75 11 (2012): 1915-1921. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870204747&partnerID=MN8TOARS.
    10.1021/np3004003
  74. Wesolowska, O.; Wisniewski, J.; Sroda-Pomianek, K.; Bielawska-Pohl, A.; Paprocka, M.; Dus, D.; Duarte, N.; Ferreira, M.-J.U.; Michalak, K.. "Multidrug resistance reversal and apoptosis induction in human colon cancer cells by some flavonoids present in citrus plants". Journal of Natural Products 75 11 (2012): 1896-1902. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870216847&partnerID=MN8TOARS.
    10.1021/np3003468
  75. Mansoor, T.A.; Ramalho, R.M.; Luo, X.; Ramalhete, C.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "Isoflavones as apoptosis inducers in human hepatoma HuH-7 cells". Phytotherapy Research 25 12 (2011): 1819-1824. http://www.scopus.com/inward/record.url?eid=2-s2.0-82155183108&partnerID=MN8TOARS.
    10.1002/ptr.3498
  76. Ramalhete, C.; Lopes, D.; Molnár, J.; Mulhovo, S.; Rosário, V.E.; Ferreira, M.-J.U.. "Karavilagenin C derivatives as antimalarials". Bioorganic and Medicinal Chemistry 19 1 (2011): 330-338. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650740963&partnerID=MN8TOARS.
    10.1016/j.bmc.2010.11.015
  77. Ferreira, R.J.; Dos Santos, D.J.V.A.; Ferreira, M.-J.U.; Guedes, R.C.. "Toward a better pharmacophore description of P-glycoprotein modulators, based on macrocyclic diterpenes from euphorbia species". Journal of Chemical Information and Modeling 51 6 (2011): 1315-1324. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959764016&partnerID=MN8TOARS.
    10.1021/ci200145p
  78. Ramalhete, C.; Da Cruz, F.P.; Lopes, D.; Mulhovo, S.; Rosário, V.E.; Prudêncio, M.; Ferreira, M.-J.U.. "Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections". Bioorganic and Medicinal Chemistry 19 24 (2011): 7474-7481. http://www.scopus.com/inward/record.url?eid=2-s2.0-82255192175&partnerID=MN8TOARS.
    10.1016/j.bmc.2011.10.044
  79. Ramalhete, C.; Spengler, G.; Martins, A.; Martins, M.; Viveiros, M.; Mulhovo, S.; Ferreira, M.-J.U.; Amaral, L.. "Inhibition of efflux pumps in meticillin-resistant Staphylococcus aureus and Enterococcus faecalis resistant strains by triterpenoids from Momordica balsamina". International Journal of Antimicrobial Agents 37 1 (2011): 70-74. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650262885&partnerID=MN8TOARS.
    10.1016/j.ijantimicag.2010.09.011
  80. Luo, X.; Pires, D.; Aínsa, J.A.; Gracia, B.; Mulhovo, S.; Duarte, A.; Anes, E.; Ferreira, M.-J.U.. "Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique". Journal of Ethnopharmacology 137 1 (2011): 114-120. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052034181&partnerID=MN8TOARS.
    10.1016/j.jep.2011.04.062
  81. Duarte, N.; Lage, H.; Abrantes, M.; Ferreira, M.-J.U.. "Phenolic compounds as selective antineoplasic agents against multidrug-resistant human cancer cells". Planta Medica 76 10 (2010): 975-980. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954916701&partnerID=MN8TOARS.
    10.1055/s-0029-1240892
  82. Duarte, N.; Lage, H.; Abrantes, M.; Ferreira, M.-J.U.. "Erratum: Phenolic compounds as selective antineoplasic agents against multidrug-resistant human cancer cells (Planta Medica (2010) DOI: 10.1055/s-0029-1240892)". Planta Medica 76 10 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-79952247821&partnerID=MN8TOARS.
    10.1055/s-0030-1249912
  83. Wesolowska, O.; Wisniewski, J.; Bielawska-Pohl, A.; Paprocka, M.; Duarte, N.; Ferreira, M.-J.U.; Dus, D.; Michalak, K.. "Stilbenes as multidrug resistance modulators and apoptosis inducers in human adenocarcinoma cells". Anticancer Research 30 11 (2010): 4587-4593. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650252900&partnerID=MN8TOARS.
  84. Kolaczkowski, M.; Kolaczkowska, A.; Sroda, K.; Ramalhete, C.; Michalak, K.; Mulhovo, S.; Ferreira, M.J.U.. "Substrates and modulators of the multidrug transporter Cdr1p of Candida albicans in antifungal extracts of medicinal plants". Mycoses 53 4 (2010): 305-310. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953346870&partnerID=MN8TOARS.
    10.1111/j.1439-0507.2009.01711.x
  85. Reis, M.; Trinca, A.; Ferreira, M.J.U.; Monsalve-Puello, A.R.; Grácio, M.A.A.. "Toxocara canis: Potential activity of natural products against second-stage larvae in vitro and in vivo". Experimental Parasitology 126 2 (2010): 191-197. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955266446&partnerID=MN8TOARS.
    10.1016/j.exppara.2010.04.023
  86. Lage, H.; Duarte, N.; Coburger, C.; Hilgeroth, A.; Ferreira, M.J.U.. "Antitumor activity of terpenoids against classical and atypical multidrug resistant cancer cells". Phytomedicine 17 6 (2010): 441-448. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950297689&partnerID=MN8TOARS.
    10.1016/j.phymed.2009.07.009
  87. Pusztai, R.; Abrantes, M.; Sherly, J.; Duarte, N.; Molnar, J.; Ferreira, M.-J.U.. "Antitumor-promoting activity of lignans: Inhibition of human cytomegalovirus IE gene expression". Anticancer Research 30 2 (2010): 451-454. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950544499&partnerID=MN8TOARS.
  88. Ramalhete, C.; Lopes, D.; Mulhovo, S.; Molnár, J.; Rosário, V.E.; Ferreira, M.-J.U.. "New antimalarials with a triterpenic scaffold from Momordica balsamina". Bioorganic and Medicinal Chemistry 18 14 (2010): 5254-5260. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955336658&partnerID=MN8TOARS.
    10.1016/j.bmc.2010.05.054
  89. Teisseyre, A.; Duarte, N.; Ferreira, M.-J.U.; Michalak, K.. "Influence of the multidrug transporter inhibitors on the activity of KV1.3 voltage-gated potassium channels". Journal of Physiology and Pharmacology 60 1 (2009): 69-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-65949088566&partnerID=MN8TOARS.
  90. Duarte, N.; Ramalhete, C.; Varga, A.; Molnár, J.; Ferreira, M.-J.U.. "Multidrug resistance modulation and apoptosis induction of cancer cells by terpenic compounds isolated from Euphorbia species". Anticancer Research 29 11 (2009): 4467-4472. http://www.scopus.com/inward/record.url?eid=2-s2.0-75149181690&partnerID=MN8TOARS.
  91. Ramalhete, C.; Molnár, J.; Mulhovo, S.; Rosário, V.E.; Ferreira, M.-J.U.. "New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells". Bioorganic and Medicinal Chemistry 17 19 (2009): 6942-6951. http://www.scopus.com/inward/record.url?eid=2-s2.0-69949133418&partnerID=MN8TOARS.
    10.1016/j.bmc.2009.08.020
  92. Mansoor, T.A.; Ramalhete, C.; Molnár, J.; Mulhovo, S.; Ferreira, M.J.U.. "Tabernines A-C, ß-carbolines from the leaves of Tabernaemontana elegans". Journal of Natural Products 72 6 (2009): 1147-1150. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650216170&partnerID=MN8TOARS.
    10.1021/np9001477
  93. Ramalhete, C.; Mansoor, T.A.; Mulhovo, S.; Molnár, J.; Ferreira, M.-J.U.. "Cucurbitane-type triterpenoids from the African plant Momordica balsamina". Journal of Natural Products 72 11 (2009): 2009-2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-73349132375&partnerID=MN8TOARS.
    10.1021/np900457u
  94. Spengler, G.; Ramalhete, C.; Martins, M.; Martins, A.; Serly, J.; Viveiros, M.; Molnár, J.; et al. "Evaluation of cucurbitane-type triterpenoids from Momordica balsamina on P-glycoprotein (ABCB1) by flow cytometry and real-time fluorometry". Anticancer Research 29 10 (2009): 3989-3993. http://www.scopus.com/inward/record.url?eid=2-s2.0-71949083688&partnerID=MN8TOARS.
  95. Mansoor, T.A.; Ramalho, R.M.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.J.U.. "Induction of apoptosis in HuH-7 cancer cells by monoterpene and ß-carboline indole alkaloids isolated from the leaves of Tabernaemontana elegans". Bioorganic and Medicinal Chemistry Letters 19 15 (2009): 4255-4258. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649949958&partnerID=MN8TOARS.
    10.1016/j.bmcl.2009.05.104
  96. Duarte, N.; Kayser, O.; Abreu, P.; Ferreira, M.J.U.. "Antileishmanial activity of piceatannol isolated from Euphorbia lagascae seeds". Phytotherapy Research 22 4 (2008): 455-457. http://www.scopus.com/inward/record.url?eid=2-s2.0-42949100387&partnerID=MN8TOARS.
    10.1002/ptr.2334
  97. Abrantes, M.; Mil-Homens, T.; Duarte, N.; Lopes, D.; Cravo, P.; Do Céu Madureira, M.; Ferreira, M.-J.U.. "Antiplasmodial activity of lignans and extracts from Pycnanthus angolensis". Planta Medica 74 11 (2008): 1408-1412. http://www.scopus.com/inward/record.url?eid=2-s2.0-52949122155&partnerID=MN8TOARS.
    10.1055/s-2008-1081317
  98. Duarte, N.; Járdánházy, A.; Molnár, J.; Hilgeroth, A.; Ferreira, M.-J.U.. "Synergistic interaction between p-glycoprotein modulators and epirubicine on resistant cancer cells". Bioorganic and Medicinal Chemistry 16 20 (2008): 9323-9330. http://www.scopus.com/inward/record.url?eid=2-s2.0-53249105258&partnerID=MN8TOARS.
    10.1016/j.bmc.2008.08.071
  99. Duarte, N.; Lage, H.; Ferreira, M.-J.U.. "Three new jatrophane polyesters and antiproliferative constituents from Euphorbia tuckeyana". Planta Medica 74 1 (2008): 61-68. http://www.scopus.com/inward/record.url?eid=2-s2.0-39149087948&partnerID=MN8TOARS.
    10.1055/s-2007-993765
  100. Duarte, N.; Ferreira, M.-J.U.; Martins, M.; Viveiros, M.; Amaral, L.. "Antibacterial activity of ergosterol peroxide against Mycobacterium tuberculosis: Dependence upon system and medium employed". Phytotherapy Research 21 7 (2007): 601-604. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447558018&partnerID=MN8TOARS.
    10.1002/ptr.2119
  101. Duarte, N.; Varga, A.; Cherepnev, G.; Radics, R.; Molnár, J.; Ferreira, M.-J.U.. "Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids". Bioorganic and Medicinal Chemistry 15 1 (2007): 546-554. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750953574&partnerID=MN8TOARS.
    10.1016/j.bmc.2006.09.028
  102. Wesolowska, O.; Wisniewski, J.; Duarte, N.; Ferreira, M.-J.U.; Michalak, K.. "Inhibition of MRP1 transport activity by phenolic and terpenic compounds isolated from Euphorbia species". Anticancer Research 27 6 B (2007): 4127-4133. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549037789&partnerID=MN8TOARS.
  103. Duarte, N.; Ferreira, M.-J.U.. "Lagaspholones A and B: Two new jatropholane-type diterpenes from euphorbia iagascae". Organic Letters 9 3 (2007): 489-492. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847079662&partnerID=MN8TOARS.
    10.1021/ol062854f
  104. Pusztai, R.; Ferreira, M.-J.U.; Duarte, N.; Engi, H.; Molnar, J.. "Macrocyclic lathyrane diterpenes as antitumor promoters". Anticancer Research 27 1 A (2007): 201-206. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847658888&partnerID=MN8TOARS.
  105. Duarte, N.; Gyémánt, N.; Abreu, P.M.; Molnár, J.; Ferreira, M.J.U.. "New macrocyclic lathyrane diterpenes, from Euphorbia lagascae, as inhibitors of multidrug resistance of tumour cells". Planta Medica 72 2 (2006): 162-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644534548&partnerID=MN8TOARS.
    10.1055/s-2005-873196
  106. Madureira, A.M.; Gyémánt, N.; Ascenso, J.R.; Abreu, P.M.; Molnár, J.; Ferreira, M.-J.U.. "Euphoportlandols A and B, tetracylic diterpene polyesters from Euphorbia portlandica and their anti-MDR effects in cancer cells". Journal of Natural Products 69 6 (2006): 950-953. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746566150&partnerID=MN8TOARS.
    10.1021/np060046r
  107. Molnár, J.; Gyémánt, N.; Tanaka, M.; Hohmann, J.; Bergmann-Leitner, E.; Molnár, P.; Deli, J.; Didiziapetris, R.; Umbelino Ferreira, M.J.. "Inhibition of multidrug resistance of cancer cells by natural diterpenes, triterpenes and carotenoids". Current Pharmaceutical Design 12 3 (2006): 287-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644854911&partnerID=MN8TOARS.
    10.2174/138161206775201893
  108. Ferreira, M.-J.U.; Duarte, N.; Gyémánt, N.; Radics, R.; Cherepnev, G.; Varga, A.; Molnár, J.. "Interaction between doxorubicin and the resistance modifier stilbene on multidrug resistant mouse lymphoma and human breast cancer cells". Anticancer Research 26 5 A (2006): 3541-3546. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750696293&partnerID=MN8TOARS.
  109. Ferreira, M.-J.U.; Gyémánt, N.; Madureira, A.M.; Molnár, J.. "Inhibition of P-glycoprotein transport activity in a resistant mouse lymphoma cell line by diterpenic lactones". Anticancer Research 25 5 (2005): 3259-3262. http://www.scopus.com/inward/record.url?eid=2-s2.0-23344452864&partnerID=MN8TOARS.
  110. Ferreira, M.-J.U.; Gyémánt, N.; Madureira, A.M.; Tanaka, M.; Koós, K.; Didziapetris, R.; Molnár, J.. "The effects of jatrophane derivatives on the reversion of MDR1- and MRP-mediated multidrug resistance in the MDA-MB-231 (HTB-26) cell line". Anticancer Research 25 6 B (2005): 4173-4178. http://www.scopus.com/inward/record.url?eid=2-s2.0-27944468181&partnerID=MN8TOARS.
  111. Valente, C.; Ferreira, M.J.U.; Abreu, P.M.; Gyémánt, N.; Ugocsai, K.; Hohmann, J.; Molnár, J.. "Pubescenes, Jatrophane Diterpenes, from Euphorbia pubescens, with Multidrug Resistance Reversing Activity on Mouse Lymphoma Cells". Planta Medica 70 1 (2004): 81-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-1242320318&partnerID=MN8TOARS.
    10.1055/s-2004-815464
  112. Madureira, A.M.; Ferreira, M.-J.U.; Gyémánt, N.; Ugocsai, K.; Ascenso, J.R.; Abreu, P.M.; Hohmann, J.; Molnár, J.. "Rearranged Jatrophane-Type Diterpenes from Euphorbia Species. Evaluation of their Effects on the Reversal of Multidrug Resistance". Planta Medica 70 1 (2004): 45-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-1242320327&partnerID=MN8TOARS.
    10.1055/s-2004-815454
  113. Madureira, A.M.; Molnár, A.; Abreu, P.M.; Molnár, J.; Ferreira, M.-J.U.. "A new sesquiterpene-coumarin ether and a new abietane diterpene and their effects as inhibitors of P-glycoprotein". Planta Medica 70 9 (2004): 828-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-5444270486&partnerID=MN8TOARS.
    10.1055/s-2004-827231
  114. Valente, C.; Pedro, M.; Duarte, A.; Nascimento Maria S.J., M.S.J.; Abreu, P.M.; Ferreira, M.-J.U.. "Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens". Journal of Natural Products 67 5 (2004): 902-904. http://www.scopus.com/inward/record.url?eid=2-s2.0-2642546475&partnerID=MN8TOARS.
    10.1021/np0400048
  115. Madureira, A.M.; Spengler, G.; Molnár, A.; Varga, A.; Molnár, J.; Abreu, P.M.; Ferreira, M.-J.U.. "Effect of Cycloartanes on Reversal of Multidrug Resistance and Apoptosis Induction on Mouse Lymphoma Cells". Anticancer Research 24 2 B (2004): 859-864. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442443147&partnerID=MN8TOARS.
  116. Valente, C.; Pedro, M.; Ascenso, J.R.; Abreu, P.M.; Nascimento, M.S.J.; Ferreira, M.-J.U.. "Euphopubescenol and euphopubescene, two new jatrophane polyesters, and lathyrane-type diterpenes from Euphorbia pubescens". Planta Medica 70 3 (2004): 244-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842536353&partnerID=MN8TOARS.
    10.1055/s-2004-815542
  117. Madureira, A.M.; Duarte, M.T.; Piedade, M.F.M.; Ascenso, J.R.; Ferreira, M.-J.U.. "Isoprenoid compounds from Euphorbia portlandica. X-ray structure of lupeportlandol, a new lupane triterpene". Journal of the Brazilian Chemical Society 15 5 (2004): 742-747. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644287810&partnerID=MN8TOARS.
    10.1590/S0103-50532004000500021
  118. Madureira, A.M.; Ascenso, J.R.; Valdeira, L.; Duarte, A.; Frade, J.P.; Freitas, G.; Ferreira, M.J.U.. "Evaluation of the antiviral and antimicrobial activities of triterpenes isolated from Euphorbia segetalis". Natural Product Research 17 5 (2003): 375-380. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141718842&partnerID=MN8TOARS.
    10.1080/14786410310001605841
  119. Valente, C.; Ferreira, M.J.U.; Abreu, P.M.; Pedro, M.; Cerqueira, F.; Nascimento, M.S.J.. "Three new jatrophane-type diterpenes from Euphorbia pubescens". Planta Medica 69 4 (2003): 361-366. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038290726&partnerID=MN8TOARS.
    10.1055/s-2003-38875
  120. Ferreira, M.-J.U.; Pinto, F.C.; Ascenso, J.R.. "Cycloartane triterpenes from Euphorbia tuckeyana". Natural Product Letters 15 5 (2001): 363-369. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035689534&partnerID=MN8TOARS.
    10.1080/10575630108041304
  121. Ferreira, M.-J.U.; Ascenso, J.R.. "Steroids and a tetracyclic diterpene from Euphorbia boetica". Phytochemistry 51 3 (1999): 439-444. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033024764&partnerID=MN8TOARS.
    10.1016/S0031-9422(98)00739-0
  122. Ferreira, M.-J.U.; Madureira, A.M.; Ascenso, J.R.. "A tetracyclic diterpene and triterpenes from Euphorbia segetalis". Phytochemistry 49 1 (1998): 179-183. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031670143&partnerID=MN8TOARS.
    10.1016/S0031-9422(97)01011-X
  123. Ascenso, J.R.; Ferreira, M.J.U.. "Assignment of carbon-13 and proton nuclear magnetic resonance spectra of madeirane triterpenes". Magnetic Resonance in Chemistry 35 9 (1997): 643-646. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031519495&partnerID=MN8TOARS.
    10.1002/(SICI)1097-458X(199709)35:9<643::AID-OMR142>3.0.CO;2-8
  124. Ferreira, M.J.U.; Duarte, A.; Ascenso, J.R.. "Antimicrobial activity and phytochemical study of Euphorbia tuckeyana". Fitoterapia 67 1 (1996): 85-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029866969&partnerID=MN8TOARS.
  125. Ferreira, M.J.; Ascenso, J.R.; Tavares, O.S.. "Boeticol, a new tetracyclic triterpene from euphorbia boetica". Journal of Natural Products 58 2 (1995): 275-279. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028940035&partnerID=MN8TOARS.
    10.1021/np50116a020
  126. Tavares, O.S.; Duarte, N.D.; Cunha, S.O.; Ascenso, J.R.; Ferreira, M.J.U.. "Triterpenoids from Euphorbia boetica". Fitoterapia 66 6 (1995): 551-552. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029558311&partnerID=MN8TOARS.
  127. Ferreira, M.J.U.; Lobo, A.M.; Nascimento, J.M.; Wyler, H.. "Tetra- and pentacyclic triterpenes from the aerial parts of Euphorbia piscatoria". Planta Medica 60 6 (1994): 581-582. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028096895&partnerID=MN8TOARS.
    10.1055/s-2006-959579
  128. Ferreira, M.J.U.; Lobo, A.M.; Wyler, H.. "Triterpenes of Euphorbia mellifera". Fitoterapia 64 4 (1993): 377-377. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027422841&partnerID=MN8TOARS.
  129. Ferreira, M.J.U.; Lobo, A.M.; Wyler, H.. "Triterpenoids and steroids from Euphorbia peplus". Fitoterapia 64 1 (1993): 85-87. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027414634&partnerID=MN8TOARS.
  130. Ferreira, M.U.; Lobo, A.M.; O'Mahoney, C.A.; Williams, D.J.; Wyler, H.. "Madeiranes, a New Class of Pentacyclic Triterpenes: D-Friedo-madeir-14-en-3ß-ol and -3-one, D:C-Friedomadeir-7-en-3ß-ol and -3-one". Helvetica Chimica Acta 74 6 (1991): 1329-1338. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001162706&partnerID=MN8TOARS.
    10.1002/hlca.19910740622
  131. Ferreira, M.J.U.; Lobo, A.M.; O'Mahoney, C.A.; Williams, D.J.; Wyler, H.. "Euferol and melliferol: Two novel triterpenoids from euphorbia mellifera". Journal of the Chemical Society, Perkin Transactions 1 1 (1990): 185-187. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049081482&partnerID=MN8TOARS.
Preprint
  1. Cátia A. Bonito; Ricardo J. Ferreira; Maria-José. U. Ferreira; Fernando Durães; Emília Sousa; Jean-Pierre Gillet; Maria Natália Cordeiro; et al. "Probing the allosteric modulation of P-glycoprotein: A medicinal chemistry approach towards the identification of non-competitive P-gp inhibitors.". 2022. https://doi.org/10.21203/rs.3.rs-2038969/v1.
    10.21203/rs.3.rs-2038969/v1

Intellectual property

Patent
  1. Maria-José U. Ferreira. 2021. "NEW PHARMACEUTICAL COMPOUNDS, METHODS AND USES THEREOF".
    Allowed
Provisional application for patent
  1. 2020. "BBIT20: A NEW INHIBITOR OF BRCA1 MEDIATED HOMOLOGOUS RECOMBINATION DNA REPAIR. Reference PPP: nº 116714. https://upin.up.pt/en/tecnologias/bbit20-new-inhibitor-brca1-mediated-homologous-recombination-dna-repair".

Other

Other output
  1. Long-range communication between transmembrane- and nucleotide-binding domains does not depend on drug binding to mutant P-glycoprotein. 2022. Bonito, C.A.; Ferreira, R.J.; Ferreira, M.-J.U.; Gillet, J.-P.; Natália Cordeiro, M.D.S.; dos Santos, D.J.V.A.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85136508438&partnerID=MN8TOARS.
    10.1101/2022.06.30.498271
  2. Does human P-glycoprotein efflux involve transmembrane alpha helix breakage?. 2019. Bonito, C.A.; Ferreira, M.U.-J.; Ferreira, R.J.; dos Santos, D.J.V.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095624350&partnerID=MN8TOARS.
    10.1101/692988
Activities

Event organisation

Event name
Type of event (Role)
Institution / Organization
2019/07/28 - 2019/07/31 Chairman of the Phytochemical Society of Europe (PSE) conference: Natural Products in Drug Discovery and Human Health (NatProdDDH)-Lisbon, Portugal, on July 28-31, 2019. (2019/07/28 - 2019/07/31)
Congress (President of the Organising Committee)
Phytochemical Society of Europe, United Kingdom

Committee member

Activity description
Role
Institution / Organization
2018 - 2022/09 Membro do Conselho Científico da Faculdade de Farmácia da Universidade de Lisboa
2016/05 - 2020/09 Membro do Conselho Diretivo (representante de Portugal e Espanha) da Phtytochemical Society of Europe
Member
2008 - 2011 Membro da Comissão Coordenadora do Conselho Científico da Faculdade de Farmácia de Lisboa
Distinctions

Award

2021 2021 Early Career Researcher Prize for Scientific Novelty (awarded to the PhD student Liliana Raimundo by BJP) BBIT20 inhibits homologous DNA repair with disruption of the BRCA1-BARD1 interaction in breast and ovarian cancer
2019 Planta Medica Award for the Most Innovative Paper 2019 https://www.thieme.de/de/planta-medica/thieme-award-winners-102968.htm

Other distinction

2022 Guest Editor Special Issue in International Journal of Molecular Sciences (MDPI): Natural Product-Derived Compounds for Targeting Multidrug Resistance in Cancer and Microorganisms
2020 Member of the Editorial Board of Plants [MDPI)
2020 Guest Editor of Special issue in Molecules (MDPI): Alkaloids in Future Drug Discovery
2019 Chairman of the Phytochemical Society of Europe (PSE) conference: Natural Products in Drug Discovery and Human Health (NatProdDDH)-Lisbon, Portugal, on July 28-31, 2019.
2019 Member of the Editorial Board of Molecules (MDPI)
2019 Guest Editor of Special issue in Phytochemistry Reviews (Springer): Natural Products in Drug Discovery and Human Health
2019 Member of the Editorial Board of Phytochemical Analysis
2019 Guest Editor of Special issue in Frontiers in Pharmacology (Frontiers): Natural Products as a Tool to Design New anti-MDR Lead Molecules
2019 Member of the Editorial Board of eFood (Wiley since 2022)
2016 Representative of Portugal and Spain in the Directive Board of the Phytochemical Society of Europe (PSE)
2016 Member of Editorial Board of Asian Pacific Journal of Tropical Biomedicine (WOLTERS KLUWER MEDKNOW)