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Maria José Umbelino Ferreira is Full Professor of Medicinal Chemistry at Faculty of Pharmacy, University of Lisbon, where she is currently the Coordinator of the Master in Medicinal and Biopharmaceutical Chemistry. She was the head of the Department of Pharmaceutical Chemistry from 2018 -2020. MJU Ferreira has published more than 130 indexed peer-reviewed papers/book chapters (Scopus: h-index 37; Google Scholar: h-index 43) and supervised/co-supervised 44 PhD/MSc students and postdoctoral fellows. She is the President of the Phytochemical Society of Europe since May 2024 and was the Vice -president(2022-2024) and the Regional Representative of the same Society for Iberia (2016-2020). She leads the research group of Natural Products Chemistry at Research Institute for Medicines (IMed.ULisboa), Faculty of Pharmacy, University of Lisbon (https://imed.ulisboa.pt/labs/maria-jose-ferreira/). She is co-founder the startup Beat Therapeutics, which main goal is to develop an anticancer drug candidate for personalized therapy. MJU Ferreira is currently member of COST Action CA17104 and she was member COST Action CM1407, COST Action BM0701 and member of management committee of COST Action B16-Multidrug Resistance Reversal. She is currently member of the Editorial board of Molecules (MDPI), Plants (MDPI) and Phytochemical Analyses (WILEY). Moreover, she was also guest editor of Frontiers in Pharmacology (Frontiers) and Phytochemistry Reviews (Springer) and International Journal of Molecular Sciences (MDPI). Having background in Organic and Medicinal Chemistry and advanced spectroscopic techniques, Maria José main research interest is the isolation of new bioactive chemical scaffolds from plant sources and molecular derivatization of selected compounds, using hemi-synthetic methodologies. Her main goal is to discover anticancer compounds for targeting multidrug-resistant cancer cells, namely ABC-transporter modulators.
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Identification

Personal identification

Full name
Maria José Umbelino Ferreira

Citation names

  • Maria-José U. Ferreira

Author identifiers

Ciência ID
CE1A-3108-AC3C
ORCID iD
0000-0002-8742-1486
Researcher Id
M-8053-2013
Scopus Author Id
7402787141

Email addresses

  • mjuferreira@ff.ulisboa.pt (Professional)

Telephones

Telephone
  • (+351) 217946475 (Professional)

Addresses

  • Faculdade de Farmácia, Universidade de Lisboa. Av. Prof. Gama Pinto, 1649-003 , Lisboa, Lisboa, Portugal (Professional)

Websites

Education
Degree Classification
2007
Concluded
 Química Farmacêutica (Título de Agregado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Unanimidade (maximal classification)
1986 - 1990
Concluded
 Farmácia (Doutoramento)
Major in Química Farmacêutica
Universidade de Lisboa Faculdade de Farmácia, Portugal
"-" (THESIS/DISSERTATION)
 Distinção e louvor/Very Good (maximal class.)
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2023/07/01 - Current Full Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal

Positions / Appointments

Category
Host institution 		Employer
2019/11 - Current Coordinator of the Master of Science in Medicinal and Biopharmaceutical Chemistry Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/01/12 - Current Group Leader- Natural Products Chemistry Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2007/09/01 - 2023/06 Associate Professor with Habilitation Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2022 Coordinator of the Second Cycles of Study at FFULisboa Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/09/07 - 2020/12 Head of the Pharmaceutical and Medicinal Chemistry Department Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/05/31 - 2020/09 Representative of Portugal and Spain in the Directive Board of the Phytochemical Society of Europe (PSE) Phytochemical Society of Europe, United Kingdom
2008/01/01 - 2019 Coordinator of the Master of Science in Pharmaceutical and Medicinal Chemistry Universidade de Lisboa Faculdade de Farmácia, Portugal
Outputs

Publications

Book chapter
  1. Duarte, Noélia; Ramalhete, Cátia; Rijo, Patrícia; Reis, Mariana Alves; Ferreira, Maria-José U.. "Stilbenoids in Grapes and Wine". In Handbook of Dietary Phytochemicals, 1005-1032. Springer Singapore, 2021.
    10.1007/978-981-15-4148-3_21
  2. Maria-José. U. Ferreira; Madureira, A.M.. Corresponding author: Maria-José. U. Ferreira. "Caffeine extraction from tea and coffee". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. United Kingdom: Royal Society of Chemistry, 2017.
    Published
  3. Zachariah, T. J.; Parthasarathy, V. A.. "Isolation and structural identification of piperine, the major alkaloid of black pepper". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, 21-40. United Kingdom: Royal Society of Chemistry, 2016.
    Published • 10.1079/9781845934057.0021
  4. Maria-José U. Ferreira. "Thin layer chromatography of plants pigments.". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom.. Royal Society of Chemistry, 2016.
  5. Maria-José U. Ferreira. "Synthesis of dibenzalacetone 2,4-dinitrophenylhydrazone derivative". In Comprehensive Organic Chemistry Experiments. 2016.
  6. Smith, Tom; Chitnis, Nakul; Penny, Melissa A.. "Malária no contexto da Química Medicinal". In DOENÇAS NEGLIGENCIADAS SOB A ÓTICA DA QUÍMICA MEDICINAL, 1-7. Brazil: EDITORA CRV, 2015.
    10.1007/978-1-4614-8757-9_80-1
  7. Maria-José U. Ferreira. "Reversal of Multidrug Resistance by Macrocyclic and Polycyclic Diterpenoids from Euphorbia species". 2012.
    Published
  8. Ferreira, M.-J.U.; Duarte, N.-A.; Michalak, K.; Varga, A.; Molnár, J.. "Piceatannol, an antitumor compound from euphorbia lagascae seeds". Elsevier, 2011.
    10.1016/B978-0-12-375688-6.10054-4
Conference paper
  1. Maria-José U. Ferreira. "SEARCHING FOR NATURAL ANTITUBERCULARS FROM MOZAMBICAN MEDICINAL PLANTS". Paper presented in Congresso Internacional Saber Tropical em Moçambique: História, Memória e Ciência Instituto de Investigação Cientifica Tropical- IICT – JBT/Jardim Botânico Tropical. Lisboa, 24-26 outubro de 2012, 2012.
  2. Maria-José U. Ferreira. "Antimalarial Activity of Some Plants Traditionally used in Mozambique". Paper presented in Workshop Plantas medicinais e práticas fitoterapêuticas nos trópicos, 2009.
  3. Maria-José U. Ferreira. "Macrocyclic diterpenes as promising effective MDR modulators in cancer cells. European Conference on the Reversal of Multidrug Resistance from Bacteria to Cancer Cells and Parasites.". Paper presented in European Conference on the Reversal of Multidrug Resistance from Bacteria to Cancer Cells and Parasites. COST Action B16 Conference Proceedings., 2006.
  4. Maria-José U. Ferreira. "Study of the Acetone and Methanol Extracts of Euphorbia segetalis in Natural Products in the New Millenium: Prospects and Industrial Application". 2002.
  5. Maria-José U. Ferreira. "A Short Side Chain Cycloartane and other Triterpenes from Euphorbia tuckeyana in Natural Products in the New Millenium: Prospects and Industrial Application". 2002.
Journal article
  1. Shirley A.R. Sancha; Simona Dobiasová; Tomáš Nejedlý; Ondrej Strnad; Jitka Viktorová; Maria-José U. Ferreira. "Lycorine and homolycorine derivatives for chemo-sensitizing resistant human ovarian adenocarcinoma cells". Phytomedicine (2024): https://doi.org/10.1016/j.phymed.2024.155460.
    10.1016/j.phymed.2024.155460
  2. Joana Ribeiro; Nikoletta Szemerédib; Bruno M.F. Gonçalves; Gabriella Spengler; Carlos Alberto Mateus Afonso; Maria-José Umbelino Ferreira. "Nitrogen-containing andrographolide derivatives with multidrug resistance reversal effects in cancer cells". RSC Medicinal Chemistry (2024): http://dx.doi.org/10.1039/d3md00711a.
    10.1039/d3md00711a
  3. Maria-José U. Ferreira. "Natural Product-Derived Compounds for Targeting Multidrug Resistance in Cancer and Microorganisms". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241814321.
    10.3390/ijms241814321
  4. Cátia A. Bonito; Ricardo J. Ferreira; Maria-José U. Ferreira; Jean-Pierre Gillet; M. Natália D. S. Cordeiro; Daniel J. V. A. dos Santos. "Long-range communication between transmembrane- and nucleotide-binding domains does not depend on drug binding to mutant P-glycoprotein". Journal of Biomolecular Structure and Dynamics (2023): 1-10. http://dx.doi.org/10.1080/07391102.2023.2181633.
    10.1080/07391102.2023.2181633
  5. Shirley A. R. Sancha; Nikoletta Szemerédi; Gabriella Spengler; Maria-José U. Ferreira. "Lycorine Carbamate Derivatives for Reversing P-glycoprotein-Mediated Multidrug Resistance in Human Colon Adenocarcinoma Cells". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24032061.
    10.3390/ijms24032061
  6. Bharathiraja, P.; Cardoso, D.S.P.; Rajendra Prasad, N.; Mulhovo, S.; Lakra, D.S.; Ferreira, M.-J.U.. "Reversal of P-glycoprotein-mediated multidrug resistance by natural N-alkylated indole alkaloid derivatives in KB-ChR-8-5 drug-resistant cancer cells". Journal of Biochemical and Molecular Toxicology 37 9 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85162634507&partnerID=MN8TOARS.
    10.1002/jbt.23421
  7. Shirley A. R. Sancha; Adriana V. Gomes; Joana B. Loureiro; Lucília Saraiva; Maria José U. Ferreira. "Amaryllidaceae-Type Alkaloids from Pancratium maritimum: Apoptosis-Inducing Effect and Cell Cycle Arrest on Triple-Negative Breast Cancer Cells". Molecules (2022): https://doi.org/10.3390/molecules27185759.
    10.3390/molecules27185759
  8. Maria-José U. Ferreira. "Alkaloids in Future Drug Discovery". Molecules (2022): https://doi.org/10.3390/molecules27041347.
    10.3390/molecules27041347
  9. Cátia Ramalhete; Bruno M. F. Gonçalves; Filipa Barbosa; Noélia Duarte; Maria-José U. Ferreira. "Momordica balsamina: phytochemistry and pharmacological potential of a gifted species". Phytochemistry Reviews (2022): https://doi.org/10.1007/s11101-022-09802-7.
    10.1007/s11101-022-09802-7
  10. Deng, Z.-F.; Bakunina, I.; Yu, H.; Han, J.; Dömling, A.; Ferreira, M.-J.U.; Zhang, J.-Y.. "Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance". Frontiers in Pharmacology 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85128434911&partnerID=MN8TOARS.
    10.3389/fphar.2022.815603
  11. Silva, C.D.; Ramalhete, C.; Spengler, G.; Mulhovo, S.; Molnar, J.; Ferreira, M.-J.U.. "Triterpenes from Momordica balsamina (African pumpkin): ABCB1 inhibition and synergistic interaction with doxorubicin in resistant cancer cells". Phytochemistry 203 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85135934829&partnerID=MN8TOARS.
    10.1016/j.phytochem.2022.113354
  12. David S. P. Cardoso; Nikoletta Szemerédi; Gabriella Spengler; Silva Mulhovo; Daniel J. V. A. dos Santos; Maria-José U. Ferreira. "Exploring the Monoterpene Indole Alkaloid Scaffold for Reversing P-Glycoprotein-Mediated Multidrug Resistance in Cancer". Pharmaceuticals 14 9 (2021): 862-862. https://doi.org/10.3390/ph14090862.
    10.3390/ph14090862
  13. Rijo P; Estévez F; Sitarek P; Ferreira MU. "Editorial: "Natural Products as a Tool to Design New anti-MDR Lead Molecules."". Frontiers in pharmacology (2021): http://europepmc.org/abstract/med/34234680.
    10.3389/fphar.2021.694674
  14. Maria-José U. Ferreira. "BBIT20 inhibits homologous DNA repair with disruption of the BRCA1-BARD1 interaction in breast and ovarian cancer". British Journal of Pharmacology (2021): http://dx.doi.org/10.1111/bph.15506.
    10.1111/bph.15506
  15. Ricardo J. Ferreira; Gabriella Spengler; Andreas Orthaber; Daniel J. V. A. dos Santos; Maria-José U. Ferreira. "Pedrolane, a Polycyclic Diterpene Scaffold Containing a Bicyclo[2.2.1]heptane System, from Euphorbia pedroi". Organic Letters (2021): https://doi.org/10.1021/acs.orglett.0c03647.
    10.1021/acs.orglett.0c03647
  16. Cardoso, D.S.P.; Kincses, A.; Nové, M.; Spengler, G.; Mulhovo, S.; Aires-de-Sousa, J.; dos Santos, D.J.V.A.; Ferreira, M.-J.U.. "Alkylated monoterpene indole alkaloid derivatives as potent P-glycoprotein inhibitors in resistant cancer cells". European Journal of Medicinal Chemistry 210 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85096047821&partnerID=MN8TOARS.
    10.1016/j.ejmech.2020.112985
  17. Ferreira, M.-J.U.. "Natural products in drug discovery and human health". Phytochemistry Reviews (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85098688547&partnerID=MN8TOARS.
    10.1007/s11101-020-09736-y
  18. Ferreira, M.-J.U.. "Correction to: Natural products in drug discovery and human health (Phytochemistry Reviews, (2021), 20, 1, (1-4), 10.1007/s11101-020-09736-y)". Phytochemistry Reviews 20 1 (2021): 5-5. http://www.scopus.com/inward/record.url?eid=2-s2.0-85102046563&partnerID=MN8TOARS.
    10.1007/s11101-021-09747-3
  19. Bruno M. F. Gonçalves; David S. P. Cardoso; Maria-José U. Ferreira. "Overcoming Multidrug Resistance: Flavonoid and Terpenoid Nitrogen-Containing Derivatives as ABC Transporter Modulators". Molecules 25 15 (2020): 3364-3364. https://doi.org/10.3390/molecules25153364.
    10.3390/molecules25153364
  20. Bonito, C.A.; Ferreira, R.J.; Ferreira, M.-J.U.; Gillet, J.-P.; Cordeiro, M.N.D.S.; dos Santos, D.J.V.A.. "Theoretical insights on helix repacking as the origin of P-glycoprotein promiscuity". Scientific Reports 10 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85086600933&partnerID=MN8TOARS.
    10.1038/s41598-020-66587-5
  21. Reis, M.A.; Matos, A.M.; Duarte, N.; Ahmed, O.B.; Ferreira, R.J.; Lage, H.; Ferreira, M.-J.U.. "Epoxylathyrane Derivatives as MDR-Selective Compounds for Disabling Multidrug Resistance in Cancer". Frontiers in Pharmacology 11 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85085216314&partnerID=MN8TOARS.
    10.3389/fphar.2020.00599
  22. Ferreira, R.J.; Gajdács, M.; Kincses, A.; Spengler, G.; dos Santos, D.J.V.A.; Ferreira, M.-J.U.. "Nitrogen-containing naringenin derivatives for reversing multidrug resistance in cancer". Bioorganic and Medicinal Chemistry 28 23 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85092096903&partnerID=MN8TOARS.
    10.1016/j.bmc.2020.115798
  23. Andreia Mónico; Cátia Ramalhete; Vânia André; Gabriella Spengler; Silva Mulhovo; M. Teresa Duarte; Maria-José U. Ferreira. "Cucurbalsaminones A–C, Rearranged Triterpenoids with a 5/6/3/6/5-Fused Pentacyclic Carbon Skeleton from Momordica balsamina, as Multidrug Resistance Reversers". Journal of Natural Products (2019): https://doi.org/10.1021/acs.jnatprod.9b00019.
    10.1021/acs.jnatprod.9b00019
  24. Neto, Sara; Duarte, Noélia; Pedro, Cecília; Spengler, Gabriella; Molnár, Joséph; Ferreira, Maria-José U.. "Effective MDR reversers through phytochemical study of Euphorbia boetica". Phytochemical Analysis 30 5 (2019): 498-511. http://dx.doi.org/10.1002/pca.2841.
    10.1002/pca.2841
  25. Ferreira, Maria-José U.; Paterna, Angela. "Monoterpene indole alkaloids as leads for targeting multidrug resistant cancer cells from the African medicinal plant Tabernaemontana elegans". Phytochemistry Reviews 18 4 (2019): 971-987. http://dx.doi.org/10.1007/s11101-019-09615-1.
    Published • 10.1007/s11101-019-09615-1
  26. Ferreira, Ricardo J.; Kincses, Annamária; Gajdács, Márió; Spengler, Gabriella; dos Santos, Daniel J. V. A.; Molnár, Joseph; Ferreira, Maria-José U.. "Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers". Journal of Natural Products 81 9 (2018): 2032-2040. http://dx.doi.org/10.1021/acs.jnatprod.8b00326.
    10.1021/acs.jnatprod.8b00326
  27. Ramalhete, Cátia; Mulhovo, Silva; Lage, Hermann; Ferreira, Maria-José. "Triterpenoids from Momordica balsamina with a Collateral Sensitivity Effect for Tackling Multidrug Resistance in Cancer Cells". Planta Medica 84 18 (2018): 1372-1379. http://dx.doi.org/10.1055/a-0651-8141.
    10.1055/a-0651-8141
  28. Ferreira, Ricardo J; Baptista, Rafael; Moreno, Alexis; Madeira, Patricia G; Khonkarn, Ruttiros; Baubichon-Cortay, Hélène; dos Santos, Daniel JVA; Falson, Pierre; Ferreira, Maria-José U. "Optimizing the flavanone core toward new selective nitrogen-containing modulators of ABC transporters". Future Medicinal Chemistry 10 7 (2018): 725-741. http://dx.doi.org/10.4155/fmc-2017-0228.
    10.4155/fmc-2017-0228
  29. Kincses, Annamária; Varga, Borisz; Csonka, Ákos; Sancha, Shirley; Mulhovo, Silva; Madureira, Ana Margarida; Ferreira, Maria-José U.; Spengler, Gabriella. "Bioactive compounds from the African medicinal plant Cleistochlamys kirkii as resistance modifiers in bacteria". Phytotherapy Research 32 6 (2018): 1039-1046. http://dx.doi.org/10.1002/ptr.6042.
    10.1002/ptr.6042
  30. Paterna, A.; Khonkarn, R.; Mulhovo, S.; Moreno, A.; Madeira Girio, P.; Baubichon-Cortay, H.; Falson, P.; Ferreira, M.-J.U.. "Monoterpene indole alkaloid azine derivatives as MDR reversal agents". Bioorganic and Medicinal Chemistry 26 2 (2018): 421-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037656553&partnerID=MN8TOARS.
    10.1016/j.bmc.2017.11.052
  31. Ferreira, Ricardo J.; Bonito, Cátia A.; Ferreira, Maria José U.; dos Santos, Daniel J.V.A.. "About P-glycoprotein: a new drugable domain is emerging from structural data". Wiley Interdisciplinary Reviews: Computational Molecular Science 7 5 (2017): e1316. http://dx.doi.org/10.1002/wcms.1316.
    10.1002/wcms.1316
  32. Reis, M.A.; Ahmed, O.B.; Spengler, G.; Molnár, J.; Lage, H.; Ferreira, M.-J.U.. "Exploring Jolkinol D Derivatives to Overcome Multidrug Resistance in Cancer". Journal of Natural Products 80 5 (2017): 1411-1420. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019719063&partnerID=MN8TOARS.
    Published • 10.1021/acs.jnatprod.6b01084
  33. Paterna, A.; Kincses, A.; Spengler, G.; Mulhovo, S.; Moln�r, J.; Ferreira, M.-J.U.. "Dregamine and tabernaemontanine derivatives as ABCB1 modulators on resistant cancer cells". European Journal of Medicinal Chemistry 128 (2017): 247-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011960889&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.01.044
  34. Ferreira, R.J.; Bonito, C.A.; Cordeiro, M.N.D.S.; Ferreira, M.-J.U.; Dos Santos, D.J.V.A.. "Structure-function relationships in ABCG2: Insights from molecular dynamics simulations and molecular docking studies". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85034244902&partnerID=MN8TOARS.
    10.1038/s41598-017-15452-z
  35. Mónico, A.; Nim, S.; Duarte, N.; Rawal, M.K.; Prasad, R.; Di Pietro, A.; Ferreira, M.-J.U.. "Lathyrol and epoxylathyrol derivatives: Modulation of Cdr1p and Mdr1p drug-efflux transporters of Candida albicans in Saccharomyces cerevisiae model". Bioorganic and Medicinal Chemistry 25 13 (2017): 3278-3284. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018347859&partnerID=MN8TOARS.
    10.1016/j.bmc.2017.04.016
  36. Paterna, A.; Gomes, S.E.; Borralho, P.M.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "(3'R)-hydroxytabernaelegantine C: A bisindole alkaloid with potent apoptosis inducing activity in colon (HCT116, SW620) and liver (HepG2) cancer cells". Journal of Ethnopharmacology 194 (2016): 236-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987934442&partnerID=MN8TOARS.
    10.1016/j.jep.2016.09.020
  37. Wisniewski, J.; Wesolowska, O.; Sroda-Pomianek, K.; Paprocka, M.; Bielawska-Pohl, A.; Krawczenko, A.; Duarte, N.; et al. "Euphorbia species-derived diterpenes and coumarins as multidrug resistance modulators in human colon carcinoma cells". Anticancer Research 36 5 (2016): 2259-2264. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017889260&partnerID=MN8TOARS.
  38. Nim, S.; Mónico, A.; Rawal, M.K.; Duarte, N.; Prasad, R.; Di Pietro, A.; Ferreira, M.-J.U.. "Overcoming Multidrug Resistance in Candida albicans: Macrocyclic Diterpenes from Euphorbia Species as Potent Inhibitors of Drug Efflux Pumps". Planta Medica 82 13 (2016): 1180-1185. http://www.scopus.com/inward/record.url?eid=2-s2.0-84965006976&partnerID=MN8TOARS.
    10.1055/s-0042-106169
  39. Reis, M.A.; Ahmed, O.B.; Spengler, G.; Molnár, J.; Lage, H.; Ferreira, M.-J.U.. "Jatrophane diterpenes and cancer multidrug resistance - ABCB1 efflux modulation and selective cell death induction". Phytomedicine 23 9 (2016): 968-978. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975318127&partnerID=MN8TOARS.
    10.1016/j.phymed.2016.05.007
  40. Paterna, A.; Gomes, S.E.; Borralho, P.M.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "Vobasinyl-Iboga Alkaloids from Tabernaemontana elegans: Cell Cycle Arrest and Apoptosis-Inducing Activity in HCT116 Colon Cancer Cells". Journal of Natural Products 79 10 (2016): 2624-2634. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994056083&partnerID=MN8TOARS.
    10.1021/acs.jnatprod.6b00552
  41. Ramalhete, C.; Mulhovo, S.; Molnar, J.; Ferreira, M.-J.U.. "Triterpenoids from Momordica balsamina: Reversal of ABCB1-mediated multidrug resistance". Bioorganic and Medicinal Chemistry 24 21 (2016): 5061-5067. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991710925&partnerID=MN8TOARS.
    10.1016/j.bmc.2016.08.022
  42. Baptista, R.; Ferreira, R.J.; Dos Santos, D.J.V.A.; Fernandes, M.X.; Ferreira, M.-J.U.. "Optimizing the macrocyclic diterpenic core toward the reversal of multidrug resistance in cancer". Future Medicinal Chemistry 8 6 (2016): 629-645. http://www.scopus.com/inward/record.url?eid=2-s2.0-84966473176&partnerID=MN8TOARS.
    10.4155/fmc.16.11
  43. Pereira, F.; Madureira, A.M.; Sancha, S.; Mulhovo, S.; Luo, X.; Duarte, A.; Ferreira, M.-J.U.. "Cleistochlamys kirkii chemical constituents: Antibacterial activity and synergistic effects against resistant Staphylococcus aureus strains". Journal of Ethnopharmacology 178 (2016): 180-187. http://www.scopus.com/inward/record.url?eid=2-s2.0-84950131229&partnerID=MN8TOARS.
    10.1016/j.jep.2015.12.009
  44. Paterna, A.; Borralho, P.M.; Gomes, S.E.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "Monoterpene indole alkaloid hydrazone derivatives with apoptosis inducing activity in human HCT116 colon and HepG2 liver carcinoma cells". Bioorganic and Medicinal Chemistry Letters 25 17 (2015): 3556-3559. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938292387&partnerID=MN8TOARS.
    10.1016/j.bmcl.2015.06.084
  45. Reis, M.A.; André, V.; Duarte, M.T.; Lage, H.; Ferreira, M.-J.U.. "12,17-Cyclojatrophane and Jatrophane Constituents of Euphorbia welwitschii". Journal of Natural Products 78 11 (2015): 2684-2690. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948844292&partnerID=MN8TOARS.
    10.1021/acs.jnatprod.5b00631
  46. Ferreira, R.J.; Ferreira, M.-J.U.; Dos Santos, D.J.V.A.. "Do Drugs Have Access to the P-Glycoprotein Drug-Binding Pocket through Gates?". Journal of Chemical Theory and Computation 11 10 (2015): 4525-4529. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944233434&partnerID=MN8TOARS.
    10.1021/acs.jctc.5b00652
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  110. Ferreira, M.-J.U.; Gyémánt, N.; Madureira, A.M.; Tanaka, M.; Koós, K.; Didziapetris, R.; Molnár, J.. "The effects of jatrophane derivatives on the reversion of MDR1- and MRP-mediated multidrug resistance in the MDA-MB-231 (HTB-26) cell line". Anticancer Research 25 6 B (2005): 4173-4178. http://www.scopus.com/inward/record.url?eid=2-s2.0-27944468181&partnerID=MN8TOARS.
  111. Valente, C.; Ferreira, M.J.U.; Abreu, P.M.; Gyémánt, N.; Ugocsai, K.; Hohmann, J.; Molnár, J.. "Pubescenes, Jatrophane Diterpenes, from Euphorbia pubescens, with Multidrug Resistance Reversing Activity on Mouse Lymphoma Cells". Planta Medica 70 1 (2004): 81-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-1242320318&partnerID=MN8TOARS.
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  112. Madureira, A.M.; Ferreira, M.-J.U.; Gyémánt, N.; Ugocsai, K.; Ascenso, J.R.; Abreu, P.M.; Hohmann, J.; Molnár, J.. "Rearranged Jatrophane-Type Diterpenes from Euphorbia Species. Evaluation of their Effects on the Reversal of Multidrug Resistance". Planta Medica 70 1 (2004): 45-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-1242320327&partnerID=MN8TOARS.
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  113. Madureira, A.M.; Molnár, A.; Abreu, P.M.; Molnár, J.; Ferreira, M.-J.U.. "A new sesquiterpene-coumarin ether and a new abietane diterpene and their effects as inhibitors of P-glycoprotein". Planta Medica 70 9 (2004): 828-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-5444270486&partnerID=MN8TOARS.
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  115. Madureira, A.M.; Spengler, G.; Molnár, A.; Varga, A.; Molnár, J.; Abreu, P.M.; Ferreira, M.-J.U.. "Effect of Cycloartanes on Reversal of Multidrug Resistance and Apoptosis Induction on Mouse Lymphoma Cells". Anticancer Research 24 2 B (2004): 859-864. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442443147&partnerID=MN8TOARS.
  116. Valente, C.; Pedro, M.; Ascenso, J.R.; Abreu, P.M.; Nascimento, M.S.J.; Ferreira, M.-J.U.. "Euphopubescenol and euphopubescene, two new jatrophane polyesters, and lathyrane-type diterpenes from Euphorbia pubescens". Planta Medica 70 3 (2004): 244-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842536353&partnerID=MN8TOARS.
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Preprint
  1. Cátia A. Bonito; Ricardo J. Ferreira; Maria-José. U. Ferreira; Fernando Durães; Emília Sousa; Jean-Pierre Gillet; Maria Natália Cordeiro; et al. "Probing the allosteric modulation of P-glycoprotein: A medicinal chemistry approach towards the identification of non-competitive P-gp inhibitors.". 2022. https://doi.org/10.21203/rs.3.rs-2038969/v1.
    10.21203/rs.3.rs-2038969/v1

Intellectual property

Patent
  1. Maria-José U. Ferreira. 2021. "NEW PHARMACEUTICAL COMPOUNDS, METHODS AND USES THEREOF".
    Allowed
Provisional application for patent
  1. 2020. "BBIT20: A NEW INHIBITOR OF BRCA1 MEDIATED HOMOLOGOUS RECOMBINATION DNA REPAIR. Reference PPP: nº 116714. https://upin.up.pt/en/tecnologias/bbit20-new-inhibitor-brca1-mediated-homologous-recombination-dna-repair".

Other

Other output
  1. Long-range communication between transmembrane- and nucleotide-binding domains does not depend on drug binding to mutant P-glycoprotein. 2022. Bonito, C.A.; Ferreira, R.J.; Ferreira, M.-J.U.; Gillet, J.-P.; Natália Cordeiro, M.D.S.; dos Santos, D.J.V.A.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85136508438&partnerID=MN8TOARS.
    10.1101/2022.06.30.498271
  2. Does human P-glycoprotein efflux involve transmembrane alpha helix breakage?. 2019. Bonito, C.A.; Ferreira, M.U.-J.; Ferreira, R.J.; dos Santos, D.J.V.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095624350&partnerID=MN8TOARS.
    10.1101/692988
Activities

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/07/28 - 2019/07/31 Chairman of the Phytochemical Society of Europe (PSE) conference: Natural Products in Drug Discovery and Human Health (NatProdDDH)-Lisbon, Portugal, on July 28-31, 2019. (2019/07/28 - 2019/07/31)
Congress (President of the Organising Committee)
 Phytochemical Society of Europe, United Kingdom

Committee member

Activity description
Role 		Institution / Organization
2018 - 2022/09 Membro do Conselho Científico da Faculdade de Farmácia da Universidade de Lisboa
2016/05 - 2020/09 Membro do Conselho Diretivo (representante de Portugal e Espanha) da Phtytochemical Society of Europe
Member
2008 - 2011 Membro da Comissão Coordenadora do Conselho Científico da Faculdade de Farmácia de Lisboa
Distinctions

Award

2021 2021 Early Career Researcher Prize for Scientific Novelty (awarded to the PhD student Liliana Raimundo by BJP) BBIT20 inhibits homologous DNA repair with disruption of the BRCA1-BARD1 interaction in breast and ovarian cancer
2019 Planta Medica Award for the Most Innovative Paper 2019 https://www.thieme.de/de/planta-medica/thieme-award-winners-102968.htm

Other distinction

2022 Guest Editor Special Issue in International Journal of Molecular Sciences (MDPI): Natural Product-Derived Compounds for Targeting Multidrug Resistance in Cancer and Microorganisms
2020 Member of the Editorial Board of Plants [MDPI)
2020 Guest Editor of Special issue in Molecules (MDPI): Alkaloids in Future Drug Discovery
2019 Chairman of the Phytochemical Society of Europe (PSE) conference: Natural Products in Drug Discovery and Human Health (NatProdDDH)-Lisbon, Portugal, on July 28-31, 2019.
2019 Member of the Editorial Board of Molecules (MDPI)
2019 Guest Editor of Special issue in Phytochemistry Reviews (Springer): Natural Products in Drug Discovery and Human Health
2019 Member of the Editorial Board of Phytochemical Analysis
2019 Guest Editor of Special issue in Frontiers in Pharmacology (Frontiers): Natural Products as a Tool to Design New anti-MDR Lead Molecules
2019 Member of the Editorial Board of eFood (Wiley since 2022)
2016 Representative of Portugal and Spain in the Directive Board of the Phytochemical Society of Europe (PSE)
2016 Member of Editorial Board of Asian Pacific Journal of Tropical Biomedicine (WOLTERS KLUWER MEDKNOW)