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Elsa’s main goal is to characterize the regulatory pathways involved in brain cholesterol homeostasis, and therefore provide a basis for the development of therapeutic approaches for diseases that stretch from genetic disorders, such as Niemann Pick Type C, to neurodegenerative disorders such as Alzheimer’s Disease. Her focus has been on the potential beneficial modulation of cholesterol homeostasis through ectopic expression or pharmacological up-regulation/activation of neuronal specific cholesterol 24-hydroxylase encoded by the cytochrome P450 CYP46A1 gene. Moreover, she has been focusing in the discovery of transcriptional regulators that can modulate neuronal cholesterol levels and in the different cellular players involved in this response.
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Identification

Personal identification

Full name
Elsa Margarida Teixeira Rodrigues

Citation names

  • Rodrigues, Elsa

Author identifiers

Ciência ID
CE1D-5FF6-DA93
ORCID iD
0000-0003-1669-365X
Researcher Id
J-3100-2012
Scopus Author Id
7102572600

Email addresses

  • elsa.rodrigues@ff.ulisboa.pt (Professional)

Telephones

Fax
  • 217946491 (Professional)
Telephone
  • 217946496 Ext.: 14528 (Professional)

Addresses

  • iMED.ULisboa - Research Institute for Medicines. Faculty of Pharmacy. Universidade de Lisboa. Av Prof. Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
French Upper intermediate (B2) Upper intermediate (B2) Elementary (A2) Upper intermediate (B2) Intermediate (B1)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese (Mother tongue)
Education
Degree Classification
2003
Concluded
 Biology (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Molecular mechanisms of the in vivo CYP3A1 induction by synthetic glucocorticoids. Interplay of transcription factors in the development- dependent response" (THESIS/DISSERTATION)
 Approved, with honour and laureate
1993
Concluded
 Recurso Faunísticos e Ambiente (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Detecção de marcadores genéticos na diferenciação das populações de Chondrostoma lusitanicum Collares-Pereira, 1980 (Pisces: Cyprinidae), das bacias da Samarra e do Mira" (THESIS/DISSERTATION)
 15/20
Affiliation

Science

Category
Host institution 		Employer
1994/10/01 - 1995/09/30 Research Trainee (Research) Instituto Gulbenkian de Ciência, Portugal
1994/01/01 - 1994/09/30 Research Trainee (Research) Universidade de Lisboa Faculdade de Ciências, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2021 - Current Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2007 - 2020 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
2001/09/01 - 2006/09/30 Assistant (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
1997/01/01 - 2001/09/30 PhD Student (PRAXIS 4/4.1/BD/2999) Universidade de Lisboa Faculdade de Farmácia, Portugal
2000/01/01 - 2000/06/30 Chercheur sur contract - Poste Rouge Inserm U1061, France
Projects

Grant

Designation Funders
2022/01 - 2023/06 Modulação da disfunção mitocondrial por sinalização redox via modificações pós-tradução
Provided by PTCRIS: EXPL/BIA-BQM/0793/2021
 Fundação para a Ciência e a Tecnologia
1999 - 2001 Role of nuclear factors PXR and C/EBPalfa in the transcriptional activation of CYP3A1 gene by glucocorticoids (Team member)
POCTI/BME/35047/99
PhD Student Fellow
Fundação para a Ciência e a Tecnologia, Portugal
1997 - 1999 Rôle du facteur de transcription C/EBP dans l’induction du gène CYP3A1 dans le foie de rat (Team Member)
PRAXIS/2/2.1/BIA/234/94
PhD Student Fellow
Fundação para a Ciência e a Tecnologia, Portugal
Concluded

Contract

Designation Funders
2018/10/01 - 2021/09/30 Exploring the biophysical link between Gaucher disease and Parkinson's disease (Team Member)
PTDC/BIA-BFS/29448/2017
Invited Scientist Fellow
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/08/01 - 2021/07/31 CYP46A1 como um novo alvo terapêutico na Doença de Niemann-Pick de tipo C (Principal Investigator)
PTDC/MED-NEU/29455/2017
Principal investigator
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/08/01 - 2021/07/31 PGC-1alpha Isoforms as novel Therapeutic targets in Parkinson's Disease ( Co-Principal Investigator)
PTDC/MED-FSL/30104/2017
 Fundação para a Ciência e a Tecnologia
Concluded
2013/06 - 2015/11 S-Glutathionylation in Parkinson´s Disease. (Team Member)
Provided by PTCRIS: 124942
Invited Scientist Fellow
Fundação para a Ciência e a Tecnologia
2013/06 - 2015/11 Unraveling the neuroprotective role of TUDCA in Parkinson´s disease: targeting oxidative stress and mitophagy (Team Member)
Provided by PTCRIS: 124452
Invited Scientist Fellow
Fundação para a Ciência e a Tecnologia
2011/01 - 2014/06 Control of neuronal signaling pathways by CYP46A1, an enzyme involved in brain cholesterol turnover (Principal Investigator)
Provided by PTCRIS: 110809
Principal investigator
Fundação para a Ciência e a Tecnologia
2007/08 - 2010/12 Estrogen signaling and epigenetic modifications in the regulation of the CYP46A1 expression in the brain (Principal Investigator)
Provided by PTCRIS: 64176
Principal investigator
Fundação para a Ciência e a Tecnologia
2007/01 - 2009/12 Somatic expression of PDHA2 gene - a long dreamed therapy (Team Member)
Provided by PTCRIS: 82551
Invited Scientist Fellow
Fundação para a Ciência e a Tecnologia
2007/01 - 2009/10 Evaluation of the protective role of Glutathione S-Transferase pi against MPTP neurotoxicity (Team Member)
Provided by PTCRIS: 82406
Invited Scientist Fellow
Fundação para a Ciência e a Tecnologia
2007/01 - 2009/10 Molecular mechanisms involved in the transcriptional regulation of the human CYP46 gene - Implications in brain cholesterol homeostasis (Principal Investigator)
Provided by PTCRIS: 82707
Principal investigator
Fundação para a Ciência e a Tecnologia
2007/01 - 2009/07 Acute and long-term injury of bilirubin to nerve cells - Looking for sensors, susceptibilities and modulators (Team Member)
Provided by PTCRIS: 82303
Invited Scientist Fellow
Fundação para a Ciência e a Tecnologia
2005/09 - 2008/06 Acute and long-term injury of bilirubin to nerve cells - Looking for sensors, susceptibilities and modulators (Team Member)
Provided by PTCRIS: 55955
Invited Scientist Fellow
Fundação para a Ciência e a Tecnologia
2005/07 - 2008/04 Evaluation of the protective role of Glutathione S-Transferase pi against MPTP neurotoxicity (Team Member)
Provided by PTCRIS: 58171
Invited Scientist Fellow
Fundação para a Ciência e a Tecnologia
2005/09 - 2008/03 Somatic expression of PDHA2 gene - a long dreamed therapy (Team Member)
Provided by PTCRIS: 57052
Invited Scientist Fellow
Fundação para a Ciência e a Tecnologia
2005/09 - 2008/02 Molecular mechanisms involved in the transcriptional regulation of the human CYP46 gene - Implications in brain cholesterol homeostasis. (Principal Investigator)
Provided by PTCRIS: 55919
Principal investigator
Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference abstract
  1. Rodrigues, Elsa. "Rodrigues E, Costa D, Moutinho M, Nunes MJ, Silva MF, Mendes De Almeida R, Carvalho AN, Castro-Caldas M, Gama MJ, Rodrigues CM and Cartier N. CYP46A1 expression modulates mitochondrial function and integrity in Niemann-Pick type C disease. Frontiers in Cellular Neuroscience 2019". 2019.
  2. Rodrigues, Elsa. "Nunes MJ, Caria I, Carvalho AN, Costa D, Castro-Caldas M, Gama MJ, Rodrigues E and Ruas JL. Unanswered role of cholesterol homeostasis in Parkinson’s disease. Frontiers in Cellular Neuroscience 2019". 2019.
  3. Rodrigues, Elsa. "Nunes MJ, Costa D, Mendes De Almeida R, Castro-Caldas M, Gama M and Rodrigues E. Targeting cholesterol metabolism in neuroblastoma by acting on HDACs. Front. Cell. Neurosci. 2019". 2019.
  4. Rodrigues, Elsa. "Carvalho AN, Tavares CLA, Rodrigues E, Castro-Caldas M, van Horssen J and Gama MJ. S-glutathionylation and endoplasmic reticulum stress in Parkinson's disease. Free Radical Biology and Medicine 2018; 120: S160". 2018.
  5. Rodrigues, Elsa. "Roberto VP, Conceição N, Nunes MJ, Rodrigues E, Cancela ML, Tiago DM. miR-214: A Novel Regulator of Chondrogenesis? Bone Abstracts 2016; 5: P221a". 2016.
  6. Rodrigues, Elsa. "Moreira S, Fonseca I, Silva-Azevedo C, Lemos L, Nunes MJ, Rodrigues E, Gama MJ, Rodrigues CMP, Castro-Caldas M. Tauroursodeoxycholic acid activates Nrf2 antioxidant system in the MPTP mouse model of Parkinson's disease. Febs Journal 2015; 282: 182-183.". 2015.
  7. Rodrigues, Elsa. "Carvalho AN, Marques C, Castro-Caldas M, Rodrigues E, Henderson CJ, Wolf RC, Pereira P, Gama MJ. In vivo Keap1 S-glutathionylation. Febs Journal 2014; 281: 134.". 2014.
  8. Rodrigues, Elsa. "Gordino G, Gama MJ, Rodrigues E, Rodrigues CMP, Castro-Caldas M. Neuroprotective effects of tauroursodeoxycholic acid upon mitochondrial dysfunction. Febs Journal 2014; 281: 357.". 2014.
  9. Rodrigues, Elsa. "Pinheiro A, Nunes MJ, Milagre I, Rodrigues E, Silva MJ, Tavares de Almeida I, Rivera I. Unveiling the regulatory mechanisms of PDHA2 gene. Journal of Inherited Metabolic Disease 2011; 34 (Suppl 3): S49-S286.". 2011.
  10. Rodrigues, Elsa. "Pinheiro A, Milagre I, Nunes MJ, Rodrigues E, Silva MJ, Almeida IT, Rivera I. Demethylation of PDHA2 gene leads to its expression in somatic tissues. Journal of Inherited Metabolic Diseases 2010; 33 (suppl 1): S93-S93.". 2010.
  11. Rodrigues, Elsa. "Neves Carvalho A, Marques C, Rodrigues E, Pereira P, Gama MJ. Effect of proteasome inhibition on MPP+- induced GSTP1 expression in SH-SY5Y cells. Neurodegenerative Disorders 2009; 6 (suppl 1): 1906.". 2009.
  12. Rodrigues, Elsa. "Castro-Caldas, M, Neves Carvalho A, Rodrigues E, Henderson CJ, Wolf CR and Gama MJ. GSTpi mediates MPTP-induced JNK activation in nigrostriatal pathways. Drug Metabolism Reviews 2009; 41 (suppl 1).". 2009.
  13. Rodrigues, Elsa. "Milagre I, Nunes MJ, Gama MJ and Rodrigues E. DNA Demethylation and histone deacetylation inhibition in the deprepression of CYP46A1 expression. Drug Metabolism Reviews 2009; 41 (suppl 1).". 2009.
  14. Rodrigues, Elsa. "Milagre I, Nunes MJ, Gama MJ, Silva RFM, Pascussi JM, Lechner MC, Rodrigues E. Role of Sp proteins in the transcriptional regulation of the brain specific CYP46A1 gene. Alzheimer's and Dementia 2008; 4 (4): T591". 2008.
  15. Rodrigues, Elsa. "Rodrigues E, Nunes MJ, Milagre I, Gama MJ. Derepression of the CYP46A1 gene transcription by histone deacetylase inhibition. Alzheimer's and Dementia 2008; 4 (4): T597.". 2008.
  16. Rodrigues, Elsa. "Castro-Caldas M, Peixeiro I, Rodrigues E, Lechner MC, Gama MJ. MPTP increases GSTP1 expression and JNK phosphorylation in C57BL/6 in mouse midbrain and striatum. Neurodegenerative Disorders 2007; 4 (suppl 1) 244.". 2007.
  17. Rodrigues, Elsa. "Castro-Caldas M, Rodrigues E, Lechner MC, Gama MJ. Glutathione S-transferase pi regulates UV-induced JNK signaling in SH-SY5Y cells. Cell Stress and Chaperones 2007; 12 (2): 2A_04_P.". 2007.
  18. Rodrigues, Elsa. "Milagre I, Rodrigues E, Gama MJ, Lechner MC. Identification of a CCAAT/enhancer binding protein (C/EBP) responsive region in the human CYP46A promoter” Alzheimer's and Dementia 2006; 2 (3): S202-3.". 2006.
Conference paper
  1. Rodrigues, Elsa. "Neves Carvalho A, Marques C, Rodrigues E, Pereira P, Gama MJ. Effect of proteasome inhibition on MPP+-induced GSTP1 expression in SH-SY5Y cells. In: New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2009. Fisher E and Hanin I (eds), Medimond International Proceedings 2009: L311C1906: 279-287.". 2009.
Conference poster
  1. Caria, Inês; Nunes, Sofia; Nunes, Maria João; Carvalho, Andreia Neves; Reis, Joana; Almeida, Rita Mendes; Castro-Caldas, Margarida; et al. "CYP46A1 Expression in NPC1 Cells May Ameliorate Autophagic Dysfunction By Facilitating Autophagosome-Lysosome Fusion". Paper presented in 20th International Symposium of the Portuguese Society for Metabolic Disorders, 2024.
  2. Caria, Inês; Nunes, Sofia; Nunes, Maria João; Carvalho, Andreia Neves; Reis, Joana; Mateus, Joana; Almeida, Rita Mendes; et al. "CYP46A1 Ameliorates Autophagic Block In NPC1 KO Hela Cells By Facilitating Direct Autophagosome-Lysosome Fusion". Paper presented in XIV Encontro de Estudantes Pós-Graduados do iMed.ULisboa, 2023.
  3. Caria, Inês; Nunes, Maria João; Ciracci, Viviana; Castanheira, Mariana; Carvalho, Andreia Neves; Castro-Caldas, Margarida; Gama, Maria João; Rodrigues, Elsa; Ruas, Jorge. "Waiting for the Green Light: Is there a cholesterol traffic jam in Parkinson's Disease?". Paper presented in 5.ª Conferência Anual da redeSAÚDE "A Health Research Agenda Towards 2030", 2021.
  4. Rodrigues, Elsa. "Caria I, Nunes, MJ, Carvalho AN, Castro-Caldas M, Gama MJ, Rodrigues E and Ruas JL. Inhibition of the mitochondrial complex I by a Parkinson’s Disease-inducing neurotoxin leads to a NPC1 phenotype in neuronal cells. 16th International Symposium of the Portuguese Society of Metabolic Disorders. Portugal, 2020. (Honorable Mention Award)". 2020.
  5. Caria, Inês; Carvalho, Andreia N.; Costa, Daniela; Castro-Caldas, Margarida; Gama, Maria João; Rodrigues, Elsa; Ruas, Jorge L.. "Deciphering the role of cholesterol homeostasis in Parkinson's disease". Paper presented in 5th Annual Meeting of the Mind-Brain College and 17th Biomedical Engineering Meeting, 2019.
  6. Faleiro, Inês; Rodrigues, Elsa; Castelo-Branco, Pedro. "Epigenetic alterations of the PI3K/Akt signaling pathway as potential pancreatic cancer biomarkers". Paper presented in Translational Research and Innovation in Human and Health Sciences, 2nd International Congress of CiiEM, 2017.
  7. Marques, Carla; Carvalho, Andreia N; Rodrigues, Elsa; Pereira, Paulo; Gama, Maria João. "Effect of proteasome inhibition on GSTpi expression in C57BL/6 mice nigrostriatal pathway in response to MPTP-induced oxidative stress". Paper presented in Translational aspects of proteolysis in neurodegenerative diseases – satellite of the FENS Forum 2010, 2010.
Journal article
  1. Nunes, M.J.; Carvalho, A.N.; Sá-Lemos, C.; Colaço, M.; Cervenka, I.; Ciraci, V.; Santos, S.G.; et al. "Sustained PGC-1a2 or PGC-1a3 expression induces astrocyte dysfunction and degeneration". European Journal of Cell Biology 103 1 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85177852769&partnerID=MN8TOARS.
    10.1016/j.ejcb.2023.151377
  2. Caria, I.; Nunes, M.J.; Ciraci, V.; Carvalho, A.N.; Ranito, C.; Santos, S.G.; Gama, M.J.; et al. "NPC1-like phenotype, with intracellular cholesterol accumulation and altered mTORC1 signaling in models of Parkinson's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1870 2 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85179468022&partnerID=MN8TOARS.
    10.1016/j.bbadis.2023.166980
  3. Nunes, M.J.; Carvalho, A.N.; Reis, J.; Costa, D.; Moutinho, M.; Mateus, J.; Mendes de Almeida, R.; et al. "Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hallmarks of Niemann-Pick type C disease but is not sufficient to halt neurodegeneration". Biochimica et Biophysica Acta - Molecular Basis of Disease 1870 3 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85181842546&partnerID=MN8TOARS.
    10.1016/j.bbadis.2023.166993
  4. Nunes, M.J.; Carvalho, A.N.; Rosa, A.I.; Videira, P.A.; Gama, M.J.; Rodrigues, E.; Castro-Caldas, M.. "Altered expression of Sialyl Lewis X in experimental models of Parkinson’s disease". Journal of Molecular Medicine (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85181870597&partnerID=MN8TOARS.
    10.1007/s00109-023-02415-3
  5. Kovalchuk, Daria Alexandrovna; Anjo, Sandra I.; Nunes, Maria João; Branco, Vasco; Santos, Fabiana; Caria, Inês; Castro-Caldas, Margarida; et al. "Cysteine redox post-translational modifications: the missing link between redox-signalling and mitochondrial dynamics and function in Parkinson's disease?". Free Radical Biology and Medicine 201 (2023): 35. http://dx.doi.org/10.1016/j.freeradbiomed.2023.03.142.
    10.1016/j.freeradbiomed.2023.03.142
  6. Mendes, M.O.; Rosa, A.I.; Carvalho, A.N.; Nunes, M.J.; Dionísio, P.; Rodrigues, E.; Costa, D.; et al. "Corrigendum to “Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy” [Mol. Cell. Neurosci., Volume 96, April 2019, Pages 1–9.] (Molecular and Cellular Neuroscience (2019) 96 (1–9), (S1044743118303907), (10.1016/j.mcn.2019.01.003))". Molecular and Cellular Neuroscience 114 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85105752069&partnerID=MN8TOARS.
    10.1016/j.mcn.2021.103626
  7. Mendes, M.O.; Rosa, A.I.; Carvalho, A.N.; Nunes, M.J.; Dionísio, P.; Rodrigues, E.; Costa, D.; et al. "Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy". Molecular and Cellular Neuroscience 96 (2019): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062101670&partnerID=MN8TOARS.
    10.1016/j.mcn.2019.01.003
  8. Carvalho, Andreia; Ranito, Catarina; Tavares, Carolina; Castro-Caldas, Margarida; Rodrigues, Elsa; Ruas, Jorge; Van Horssen, Jack; Gama, Maria. "Activation of the Unfolded Protein Response in Parkinson's disease". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/conf.fncel.2019.01.00051.
    10.3389/conf.fncel.2019.01.00051
  9. Nunes, Maria; Caria, Ines; Carvalho, Andreia; Costa, Daniela; Castro-Caldas, Margarida; Gama, Maria; Rodrigues, Elsa; Ruas, Jorge. "Unanswered role of cholesterol homeostasis in Parkinson's disease". 13 (2019):
    10.3389/conf.fncel.2019.01.00024
  10. Rodrigues, Elsa; Costa, Daniela; Moutinho, Miguel; Nunes, Maria; Silva, Margarida; Mendes De Almeida, Rita; Carvalho, Andreia; et al. "CYP46A1 expression modulates mitochondrial function and integrity in Niemann-Pick type C disease". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/conf.fncel.2019.01.00030.
    10.3389/conf.fncel.2019.01.00030
  11. Carvalho, Andreia Neves; Tavares, Carolina Pereira; Rodrigues, Elsa; Castro-Caldas, Margarida; van Horssen, Jack; Gama, Maria João. "S-glutathionylation and endoplasmic reticulum stress in Parkinson's disease". Free Radical Biology and Medicine 120 (2018): S160. http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.527.
    10.1016/j.freeradbiomed.2018.04.527
  12. Roberto, Vania Palma; Gavaia, Paulo; Nunes, Maria Joao; Rodrigues, Elsa; Cancela, Maria Leonor; Tiago, Daniel Martins. "Evidences for a New Role of miR-214 in Chondrogenesis". Scientific Reports 8 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000426151800037&KeyUID=WOS:000426151800037.
    10.1038/s41598-018-21735-w
  13. Rosa, Alexandra Isabel; Duarte-Silva, Sara; Silva-Fernandes, Anabela; Nunes, Maria Joao; Carvalho, Andreia Neves; Rodrigues, Elsa; Gama, Maria Joao; et al. "Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson's Disease". Molecular Neurobiology 55 12 (2018): 9139-9155. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000448483400027&KeyUID=WOS:000448483400027.
    10.1007/s12035-018-1062-4
  14. Fonseca, I.; Gordino, G.; Moreira, S.; Nunes, M.J.; Azevedo, C.; Gama, M.J.; Rodrigues, E.; Rodrigues, C.M.P.; Castro-Caldas, M.. "Tauroursodeoxycholic Acid Protects Against Mitochondrial Dysfunction and Cell Death via Mitophagy in Human Neuroblastoma Cells". Molecular Neurobiology 54 8 (2017): 6107-6119. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989831585&partnerID=MN8TOARS.
    10.1007/s12035-016-0145-3
  15. Moutinho, M.; Nunes, M.J.; Rodrigues, E.. "The mevalonate pathway in neurons: It's not just about cholesterol". Experimental Cell Research 360 1 (2017): 55-60. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013387700&partnerID=MN8TOARS.
    10.1016/j.yexcr.2017.02.034
  16. Moreira, S.; Fonseca, I.; Nunes, M.J.; Rosa, A.; Lemos, L.; Rodrigues, E.; Carvalho, A.N.; et al. "Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease". Experimental Neurology 295 (2017): 77-87. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020310862&partnerID=MN8TOARS.
    10.1016/j.expneurol.2017.05.009
  17. Rosa, A.I.; Fonseca, I.; Nunes, M.J.; Moreira, S.; Rodrigues, E.; Carvalho, A.N.; Rodrigues, C.M.P.; Gama, M.J.; Castro-Caldas, M.. "Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1863 9 (2017): 2171-2181. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021192126&partnerID=MN8TOARS.
    10.1016/j.bbadis.2017.06.004
  18. Reis-Pardal, J.; Rodrigues, A.; Rodrigues, E.; Fernandez-Llimos, F.. "Comparing cytochrome P450 pharmacogenetic information available on United States drug labels and European Union Summaries of Product Characteristics". Pharmacogenomics Journal 17 6 (2017): 488-493. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973157319&partnerID=MN8TOARS.
    10.1038/tpj.2016.40
  19. Fonseca, I.; Gordino, G.; Moreira, S.; Nunes, M.J.; Azevedo, C.; Gama, M.J.; Rodrigues, E.; Rodrigues, C.M.P.; Castro-Caldas, M.. "Erratum to: Tauroursodeoxycholic Acid Protects Against Mitochondrial Dysfunction and Cell Death via Mitophagy in Human Neuroblastoma Cells (Molecular Neurobiology, (2017), 54, 8, (6107-6119), 10.1007/s12035-016-0145-3)". Molecular Neurobiology 54 8 (2017): 6120-6120. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992146179&partnerID=MN8TOARS.
    10.1007/s12035-016-0228-1
  20. Roberto, Vania P; Conceicao, Natercia; Nunes, Maria J; Rodrigues, Elsa; Cancela, M Leonor; Tiago, Daniel M. "miR-214: a novel regulator of chondrogenesis?". Bone Abstracts (2016): http://dx.doi.org/10.1530/boneabs.5.p221a.
    10.1530/boneabs.5.p221a
  21. Carvalho, A.N.; Marques, C.; Guedes, R.C.; Castro-Caldas, M.; Rodrigues, E.; Van Horssen, J.; Gama, M.J.. "S-Glutathionylation of Keap1: A new role for glutathione S-transferase pi in neuronal protection". FEBS Letters 590 10 (2016): 1455-1466. http://www.scopus.com/inward/record.url?eid=2-s2.0-84965157697&partnerID=MN8TOARS.
    10.1002/1873-3468.12177
  22. Moutinho, M.; Nunes, M.J.; Correia, J.C.; Gama, M.J.; Castro-Caldas, M.; Cedazo-Minguez, A.; Rodrigues, C.M.P.; et al. "Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84981276916&partnerID=MN8TOARS.
    10.1038/srep30928
  23. Moutinho, M.; Nunes, M.J.; Rodrigues, E.. "Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond". Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1861 12 (2016): 1911-1920. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988615453&partnerID=MN8TOARS.
    10.1016/j.bbalip.2016.09.011
  24. Moutinho, M.; Nunes, M.J.; Gomes, A.Q.; Gama, M.J.; Cedazo-Minguez, A.; Rodrigues, C.M.P.; Björkhem, I.; Rodrigues, E.. "Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells". Molecular Neurobiology 51 3 (2015): 1489-1503. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939872953&partnerID=MN8TOARS.
    10.1007/s12035-014-8828-0
  25. Nunes, M.J.; Moutinho, M.; Gama, M.J.; Rodrigues, C.M.P.; Rodrigues, E.. "Histone Deacetylase Inhibition Decreases Cholesterol Levels in Neuronal Cells by Modulating Key Genes in Cholesterol Synthesis, Uptake and Efflux". PLoS ONE 8 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84872249052&partnerID=MN8TOARS.
    10.1371/journal.pone.0053394
  26. Carvalho, A.N.; Marques, C.; Rodrigues, E.; Henderson, C.J.; Wolf, C.R.; Pereira, P.; Gama, M.J.. "Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice.". Molecular neurobiology 47 2 (2013): 662-672. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886087240&partnerID=MN8TOARS.
  27. Castro-Caldas, M.; Carvalho, A.N.; Rodrigues, E.; Henderson, C.J.; Wolf, C.R.; Rodrigues, C.M.P.; Gama, M.J.. "Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease". Molecular Neurobiology 46 2 (2012): 475-486. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868089556&partnerID=MN8TOARS.
    10.1007/s12035-012-8295-4
  28. Carvalho, A.N.; Marques, C.; Rodrigues, E.; Henderson, C.J.; Wolf, C.R.; Pereira, P.; Gama, M.J.. "Ubiquitin-Proteasome System Impairment and MPTP-Induced Oxidative Stress in the Brain of C57BL/6 Wild-type and GSTP Knockout Mice". Molecular Neurobiology (2012): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868249992&partnerID=MN8TOARS.
    10.1007/s12035-012-8368-4
  29. Milagre, I.; Nunes, M.J.; Castro-Caldas, M.; Moutinho, M.; Gama, M.J.; Rodrigues, E.. "Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter". Journal of Neurochemistry 120 2 (2012): 220-229. http://www.scopus.com/inward/record.url?eid=2-s2.0-84155160627&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2011.07577.x
  30. Milagre, I.; Olin, M.; Nunes, M.J.; Moutinho, M.; Lövgren-Sandblom, A.; Gama, M.J.; Björkhem, I.; Rodrigues, E.. "Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells". Neurochemistry International 60 2 (2012): 192-198. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855464848&partnerID=MN8TOARS.
    10.1016/j.neuint.2011.12.003
  31. Pinheiro, A.; Nunes, M.J.; Milagre, I.; Rodrigues, E.; Silva, M.J.; de Almeida, I.T.; Rivera, I.. "Demethylation of the coding region triggers the activation of the human testis-specific PDHA2 gene in somatic tissues". PLoS ONE 7 6 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84861752214&partnerID=MN8TOARS.
    10.1371/journal.pone.0038076
  32. Castro-Caldas, M.; Carvalho, A.N.; Rodrigues, E.; Henderson, C.; Wolf, C.R.; Gama, M.J.. "Glutathione S-transferase pi mediates MPTP-induced c-Jun N-terminal kinase activation in the nigrostriatal pathway". Molecular Neurobiology 45 3 (2012): 466-477. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867475229&partnerID=MN8TOARS.
    10.1007/s12035-012-8266-9
  33. Nunes, M.J.; Moutinho, M.; Milagre, I.; Gama, M.J.; Rodrigues, E.. "Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway". Journal of Lipid Research 53 9 (2012): 1910-1919. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864848297&partnerID=MN8TOARS.
    10.1194/jlr.M027680
  34. Nunes, M.J.; Milagre, I.; Schnekenburger, M.; Gama, M.J.; Diederich, M.; Rodrigues, E.. "Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription". Journal of Neurochemistry 113 2 (2010): 418-431. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949724640&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2010.06612.x
  35. Milagre, I.; Nunes, M.J.; Moutinho, M.; Rivera, I.; Fuso, A.; Scarpa, S.; Gama, M.J.; Rodrigues, E.. "Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination". Journal of Alzheimer's Disease 22 4 (2010): 1209-1221. http://www.scopus.com/inward/record.url?eid=2-s2.0-79751484908&partnerID=MN8TOARS.
    10.3233/JAD-2010-100651
  36. Castro-Caldas, M.; Neves Carvalho, A.; Peixeiro, I.; Rodrigues, E.; Lechner, M.C.; Gama, M.J.. "GSTpi expression in MPTP-induced dopaminergic neurodegeneration of C57BL/6 mouse midbrain and striatum". Journal of Molecular Neuroscience 38 2 (2009): 114-127. http://www.scopus.com/inward/record.url?eid=2-s2.0-69249220443&partnerID=MN8TOARS.
    10.1007/s12031-008-9141-z
  37. Castro-Caldas, M.; Milagre, I.; Rodrigues, E.; Gama, M.J.. "Glutathione S-transferase pi regulates UV-induced JNK signaling in SH-SY5Y neuroblastoma cells". Neuroscience Letters 451 3 (2009): 241-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-59149094693&partnerID=MN8TOARS.
    10.1016/j.neulet.2009.01.017
  38. Milagre, Ines; Nunes, Maria Joao; Gama, Maria Joao; Rodrigues, Elsa. "DNA Demethylation and Histone Deacetylation Inhibition in the Derepression of CYP46A1 Expression". Drug Metabolism Reviews 41 (2009): 22-23. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000280164800042&KeyUID=WOS:000280164800042.
  39. Milagre, I.; Nunes, M.J.; Gama, M.J.; Silva, R.F.; Pascussi, J.M.; Lechner, M.C.; Rodrigues, E.. "Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors". Journal of Neurochemistry 106 2 (2008): 835-849. http://www.scopus.com/inward/record.url?eid=2-s2.0-51649087490&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2008.05442.x
  40. Milagre, I.; Nunes, M.J.; Gama, M.J.; Silva, R.F.; Pascussi, J.M.; Lechner, M.C.; Rodrigues, E.. "Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors (Journal of Neurochemistry (2008) 106, (835-849))". Journal of Neurochemistry 107 4 (2008): 1168-1168. http://www.scopus.com/inward/record.url?eid=2-s2.0-54349103837&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2008.05654.x
  41. Vilar, R.; Coelho, H.; Rodrigues, E.; Gama, M.J.; Rivera, I.; Taioli, E.; Lechner, M.C.. "Association of A313 G polymorphism (GSTP1*B) in the glutathione-S-transferase P1 gene with sporadic Parkinson's disease". European Journal of Neurology 14 2 (2007): 156-161. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846433663&partnerID=MN8TOARS.
    10.1111/j.1468-1331.2006.01590.x
  42. Rodrigues, E.; Vilarem, M.-J.; Ribeiro, V.; Maurel, P.; Lechner, M.C.. "Two CCAAT/enhancer binding protein sites in the cytochrome p4503A1 locus: Potencial role in the glucocorticoid response". European Journal of Biochemistry 270 3 (2003): 556-564. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037315606&partnerID=MN8TOARS.
    10.1046/j.1432-1033.2003.03413.x
  43. Ferrini, J.-B.; Rodrigues, E.; Dulic, V.; Pichard-Garcia, L.; Fabre, J.-M.; Blanc, P.; Maurel, P.. "Expression and DNA-binding activity of C/EBPa and C/EBPß in human liver and differentiated primary hepatocytes". Journal of Hepatology 35 2 (2001): 170-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034868521&partnerID=MN8TOARS.
    10.1016/S0168-8278(01)00112-X
  44. Collares-Pereira, M.J.; Próspero, M.I.; Biléu, R.I.; Rodrigues, E.M.. "Leuciscus (Pisces, Cyprinidae) karyotypes: Transect of Portuguese populations". Genetics and Molecular Biology 21 1 (1998): 63-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-2642615376&partnerID=MN8TOARS.
    10.1590/S1415-47571998000100011
  45. Coelho, M.M.; Alves, M.J.; Rodrigues, E.. "Patterns of genetic divergence in Chondrostoma lusitanicum Collares-Pereira, in intermittent Portuguese rivers". Fisheries Management and Ecology 4 3 (1997): 223-232. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000079911&partnerID=MN8TOARS.
    10.1046/j.1365-2400.1997.00124.x
  46. Rodrigues, E.; Collares-Pereira, M.J.. "NOR polymorphism in the Iberian species Chondrostoma lusitanicum (Pisces: Cyprinidae)". Genetica 98 1 (1996): 59-63. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029847445&partnerID=MN8TOARS.
    10.1007/BF00120219
Magazine article
  1. Rodrigues, Elsa. "E Rodrigues. Agressões ambientais e factores genéticos de risco individual na doença de Parkinson. Mundo Farmacêutico.16: 16-7.", 2005
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/06 Nunes MJ, Carvalho A, Costa D, Mendes de Almeida R, Risso D, Brito S, Mateus J, Xapelli S, Di genes MJ, Piguet F, Gama MJ, Castro-Caldas M, Cartier N and Elsa Rodrigues. CYP46A1 ectopic expression corrects pathological cholesterol accumulation in Npc1tm(I1061T) mice cerebellum. Michael, Marcia, and Christa Parseghian Scientific Conference for Niemann-Pick Type C Research, Virtual Symposiums. June 2021. [selected oral communication] Michael, Marcia, and Christa Parseghian Scientific Conference for Niemann-Pick Type C Research, Virtual Symposiums.
2019 Rodrigues E. CYP46A1 as a new therapeutic target in Niemann-Pick type C disease. 15th International Symposium of the Portuguese Society for Metabolic Diseases. Coimbra, Portugal, 2019.
(Portugal)
2019 Rodrigues E. CYP46A1 in neurons: it’s not just about cholesterol hydroxylation. The 7th Mediterranean Neuroscience Conference. Marrakech, Morocco, 2019.
(Morocco)
2019 Nunes MJ, Costa D, Mendes de Almeida R, Castro-Caldas M, Gama MJ and Rodrigues E. Identification of HDACs involved in the control of brain cholesterol metabolism. The 7th Mediterranean Neuroscience Conference. Marrakech, Morocco, 2019.
(Morocco)
2019 Costa D, Moutinho M, Nunes MJ, Silva MF, Mendes de Almeida R, Carvalho AN, Castro-Caldas M, Gama MJ, Rodrigues CM and Cartier N, Rodrigues E. CYP46A1 expression modulates mitochondrial function and integrity in Niemann-Pick type C disease. XVI Congresso da Sociedade Portuguesa de Neurociências (SPN2019). Lisboa, 2019.
(Portugal)
2018 Rosa AI, Duarte-Silva S, Silva-Fernandes A, Nunes MJ, Carvalho AN, Rodrigues E, Gama MJ, Rodrigues CMP, Maciel P, Castro-Caldas M. Tauroursodeoxycholic acid improves motor symptoms in a mouse model of Parkinson's disease. Congresso Sociedade Portuguesa de Doenças do Movimento 2018 - “Genética nas Doenças do Movimento”. Curia, 2018
(Portugal)
2017 Rodrigues E. Brain cholesterol metabolism: Secrets and lies. Saint Joseph University Seminars, Macau, China, 2017.
(Macau SAR China)
2017 Rodrigues E. Brain cholesterol metabolism: Secrets and lies. CEDOC Seminars. Lisboa, 2017.
(Portugal)
2017 Rodrigues E. Cholesterol 24S-hydroxylase as a new therapeutic target in Niemann-Pick type C disease 13th Symposium of the Portuguese Society for Metabolic Disorders. Évora, 2017.
(Portugal)
2017 Nunes MJ, Moutinho M, Costa D, Castro-Caldas M, Gama MJ, Rodrigues CMP, Rodrigues E. CYP46A1 as a therapeutic target in neurodegenerative disorders with altered brain cholesterol homeostasis 4.ª Conferência Anual da Rede Saúde, Lisboa, Reitoria da Universidade de Lisboa, 2017.
(Portugal)
2015 Carvalho AN, Azevedo C, Rodrigues E, Castro-Caldas M and Gama MJ. Modulation of the Unfolded Protein Response and Antioxidant Response by S-glutathionylation. Young Scientist Program of the 23rd Congress of the International Union of Biochemistry and Molecular Biology (IUBMB) and 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology (SBBq), São Paulo, Brazil, 2015.
(Brazil)
2015 Moutinho M, Nunes MJ, Gama MJ, Rodrigues CMP, Björkhem I, Ruas JL and Rodrigues E. CYP46A1 as a putative target for diabetes-induced brain dysfunction. SRP Diabetes Retreat, Estocolmo, Suécia, 2015.
(Sweden)
2015 Silva-Azevedo C, Carvalho AN, Santos M, Nunes MJ, Rodrigues E, Castro-Caldas M, Gama MJ. TUDCA modulates the ER stress response in the brain of C57BL/6 mice. XLV Annual SPF Meeting, NOVA Medical School, Lisboa, 2015.
(Portugal)
2015 Moutinho M, Nunes MJ, Gama MJ, Rodrigues CMP, Björkhem I, Ruas JL, Rodrigues E. Neuronal cholesterol metabolism activates GGTase-I and Trk increasing dendritic outgrowth and protrusion density 1º Encontro de Alunos de Doutoramento do Colégio Mente-Cérebro da Universidade de Lisboa. Reitoria da Universidade de Lisboa, Lisboa, 2015.
(Portugal)
2015 Moutinho M, Nunes MJ, Gama MJ, Rodrigues CMP, Björkhem I, Ruas JL, Rodrigues E. Neuronal cholesterol metabolism induces dendritic outgrowth and synaptic function by regulating Trk-GGTase-I interaction. 7th iMed.ULisboa Postgraduate Students Meeting. Faculdade de Farmácia, Universidade de Lisboa, Lisboa, 2015.
(Portugal)
2015 Santos MA, Carvalho AN, Silva-Azevedo C, Castro-Caldas M, Rodrigues E, Gama MJ Characterization of the effects of MPTP insult on endoplasmic reticulum stress response in C57/BL6 wild type and Gstp null mice brain. 29ª Reunião do Grupo de Estudo de Envelhecimento Cerebral e Demências (GEECD), Aveiro, 2015
(Portugal)
2014 Moutinho M, Nunes, MJ, Gama MJ, Rodrigues CMP, Bjorkhem I, and Rodrigues E. CYP46A1 increases neuronal development and the content of synaptic proteins in a prenylation-dependent manner. 4TH ENOR Symposium - Translational Research on Oxysterols. Coimbra, Portugal 2014.
(Portugal)
2014 Silva SC, Lucas SD, Guedes RA, Rodrigues E, Guedes RC. Novel Selective HDAC1 and HDAC2 Inhibitors Guided By Structure-Based Design. XXIII International Symposium on Medicinal Chemistry (EFMC-ISMC 2014), Lisbon, Portugal, 2014
(Portugal)
2014 Fonseca I, Moreira S, Silva-Azevedo C, Nunes MJ, Gordino G, Gama MJ, Rodrigues E, Rodrigues CMP, Castro-Caldas C. Mechanisms involved in TUDCA-dependent neuroprotection: Is mitophagy involved? Reunião Anual da Sociedade Portuguesa de Farmacologia, Lisbon, Portugal, February 2014
(Portugal)
2014 Moreira S, Fonseca I, Silva-Azevedo C, Nunes MJ, Gama MJ, Rodrigues E, Rodrigues CMP, Castro-Caldas M. Nrf2 regulation by TUDCA in a mouse model of Parkinson's disease. Reunião Anual da Sociedade Portuguesa de Farmacologia, Lisboa, 2014
(Portugal)
2013 Nunes MJ, Milagre I, Moutinho M, Gama MJ and Rodrigues E. Retinoic acid represses CYP46A1 gene transcription by inducing the recruitment of phosporylated ERK1/2 to the Sp3-rich proximal promoter 54th International Conference on the Bioscience of Lipids: Linking Transcription to Physiology in Lipidomics, Bari, Italy 2013
(Italy)
2013 Moutinho M, Nunes, MJ, Gama MJ, Rodrigues CMP and Rodrigues E. CYP46A1 overexpression enhances sGTPases membrane association and consequently inhibits the LXR pathway in neurons. 54th International Conference on the Bioscience of Lipids: Linking Transcription to Physiology in Lipidomics, Bari, Itália 2013.
(Italy)
2012 Rodrigues E. Brain cytochrome P450 enzymes: from xenobiotic metabolism to a role in cognitive functions. V Congresso Científico da APEF – Farmacogenómica – Luxo ou Necessidade. Porto, 2012.
(Portugal)
2012 Nunes MJ, Moutinho M, Milagre I, Gama MJ, Rodrigues E. The usual suspects: How Sp3-ERK1/2 mediate the derepression of CYP46A1 gene by the histone deacetylase inhibitor trichostatin A. RNA 2012. Lisboa, 2012.
(Portugal)
2011 Nunes MJ, Milagre I, Castro-Caldas M, Moutinho M, Gama MJ, Rodrigues E. Neuronal differentiation alter the ratio of Sp transcription factors recruited to the CYP46A1 promoter. 17th International Conference on Cytochromes P450. Manchester, Reino Unido, 2011
(United Kingdom)
2011 Moutinho M, Nunes MJ, Milagre I, Gama MJ, Rodrigues E. Role of CYP46A1 in small GTPases isoprenylation. 25ª Reunião do Grupo de Estudo de Envelhecimento Cerebral e Demências, Tomar, 2011.
(Portugal)
2011 Nunes MJ, Milagre I, Castro-Caldas M, Moutinho M, Gama MJ, Rodrigues E. Neuronal differentiation alter the ratio of Sp transcription factors recruited to the CYP46A1 promoter. 25ª Reunião do Grupo de Estudo de Envelhecimento Cerebral e Demências, Tomar, 2011.
(Portugal)
2011 Nunes, MJ, Moutinho, M, Milagre I, Gama, MJ, Rodrigues, E. The usual suspects: How Sp3 transcription factor mediates the inhibitory effect of okadaic acid treatment in the derepression of CYP46A1 gene by the histone deacetylase inhibitor trichostatin A. 3rd iMed.UL Post-­-Graduate Students Meeting, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, 2011
(Portugal)
2010 HDAC inhibitors on CYP46A1 gene expression. Tuesday Seminars in Biosciences - Université du Luxembourg. Luxemburgo, 2010.
(Luxembourg)
2010 Carvalho AN, Marques C, Rodrigues E, Pereira P, Gama MJ. Effect of proteasome inhibition on GSTpi expression in C57BL/6 mice nigrostriatal pathway in response to MPTP-induced oxidative stress. Translational aspects of proteolysis in neurodegenerative diseases – satellite of the 7th FENS Forum of European Neuroscience Maastricht, Holanda, 2010.
(Netherlands)
2010 Rodrigues E. Epigenetic regulation of CYP46A1, a key player in brain cholesterol elimination. Lisbon Area Neuroscience Meeting. IMM, Lisboa, 2010.
(Portugal)
2010 Milagre I, Nunes MJ, Moutinho M, Rivera I, Fuso A, Scarpa S, Gama MJ, Rodrigues E. Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination. 24ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência. Tomar, 2010.
(Portugal)
2010 Milagre I, Nunes MJ, Moutinho M, Rivera I, Fuso A, Scarpa S, Gama MJ, Rodrigues E. Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination. 2nd Post-Graduate iMed.UL Students Meeting. Faculdade de Farmácia, Universidade de Lisboa, Lisboa, 2010.
(Portugal)
2010 Moutinho M, Nunes MJ, Milagre I, Gama MJ, Rodrigues E. CYP46A1 induction by HDAC inhibitors depends on protein phosphatase 2a activity. 24ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência. Tomar, 2010.
(Portugal)
2010 Carvalho AN, Marques C, Rodrigues E, Pereira P, Gama MJ. Gstpi expression in C57Bl/6 mice nigrostriatal pathway in response to MPTP-induced oxidative stress and proteasome inhibition. 24ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência. Tomar, 2010.
(Portugal)
2010 Nunes MJ, Milagre I, Moutinho M, Castro-Caldas M, Gama MJ, Rodrigues E. Cross-talk between RAR¿ and Sp transcripition factors is responsible for repression of CYP46A1 gene expression by retinoic acid. 24ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência. Tomar, 2010.
(Portugal)
2010 Pinheiro A, Faustino I, Milagre I, Nunes MJ, Rodrigues E, Silva MJ, Tavares de Almeida I, Rivera I. PDH2 gene activation: could a testis-specific gene rescue the somatic energy metabolism? XVII Congresso Nacional de Bioquímica. Porto, 2010.
(Portugal)
2010 Pinheiro A, Milagre I, Rodrigues E, Silva MJ, Tavares de Almeida I, Rivera I. Unravelling the mechanisms of PDHA2 gene regulation. 2nd Post-Graduate iMed.UL Students Meeting. Faculdade de Farmácia, Universidade de Lisboa, Lisboa, 2010.
(Portugal)
2009 Carvalho AN, Marques C, Rodrigues E, Pereira P, Gama MJ. Effect of proteasomal modulation on GSTPi expression in response to MPTP/MPP+-induced oxidative stress. 1st Post-Graduated iMed.UL Students Meeting. Faculdade de Farmácia, Universidade de Lisboa, Lisboa, 2009.
(Portugal)
2009 Nunes MJ, Milagre I, Gama MJ, Rodrigues E. Sp proteins have a critical role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription. 23ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência. Tomar, 2009
(Portugal)
2008 Rodrigues E. Role of CYP46A1 in brain cholesterol homeostasis. Simpósio From Biochemistry to Pharmacogenetics: a journey of a life-time - A tribute to honour Professor Maria Celeste Lechner. Faculdade de Farmácia da Universidade de Lisboa, Lisboa, 2008
(Portugal)
2008 Gama MJ, Carvalho AN, Rodrigues E, Castro-Caldas M, Rodrigues CMP. Evaluation of the protective role of glutathione S-transferase pi against MPTP neurotoxicity. 1st iMed.UL Meeting. Faculdade de Farmácia, Universidade de Lisboa, Lisboa, 2008.
(Portugal)
2008 Rodrigues CMP, Gama MJ, Moreira da Silva IB, Rodrigues E, Solá S, Castro Caldas M, Castro RE, Ramalho RM, Nunes AF, Amaral JD, Borralho PM, Aranha MM, Viana RJS, Milagre I, Santos DM, Carvalho AN, Nunes MJ. Molecular and Cell Biology of Eukaryotic Systems. 1st iMed.UL Meeting. Faculdade de Farmácia, Universidade de Lisboa, Lisboa, 2008
(Portugal)
2008 Rodrigues E, Milagre I, Nunes MJ, Gama MJ, Rodrigues CM. Role of CYP46A1 in brain cholesterol homeostasis. 1st iMed.UL Meeting. Faculdade de Farmácia, Universidade de Lisboa, Lisboa, 2008
(Portugal)
2007 Nunes MJ, Milagre I, Gama MJ, Silva RFM, Fernandes A, Lechner MC, Rodrigues E. The brain-specific Sp4 transcription factor is a major regulator of the CYP46A1 gene. 21ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência. Luso, 2007
(Portugal)
2006 Rodrigues E. Agressões ambientais na etiologia das doenças neurodegenerativas. I Congresso Científico de Saúde AEFFUL – Doenças Neurodegenerativas – A Ciência ao dispor da Mente. Faculdade de Farmácia da Universidade de Lisboa, Lisboa, 2006.
(Portugal)
2006 Milagre I, Gama MJ, Lechner MC, Rodrigues E. The brain-specific expression of the CYP46A1 gene is regulated by Sp1 and Sp3 transcription factors. 20ª Reunião do Grupo de Envelhecimento Cerebral e Demência. Tomar, 2006.
(Portugal)
2005 Bruno S, Rodrigues E, Coelho H, Lechner MC. CYP2E1 polymorphism and susceptibility to Parkinson’s disease in a portuguese population. 2º Congresso da Sociedade Portuguesa de Ciências Farmacêuticas. Coimbra, 2005.
(Portugal)
2005 Castro-Caldas M, Gama MJ, Carvalho AN, Rodrigues E, Lechner MC. Changes in apoptotic pathways in the MPTP mouse model of Parkinson’s Disease. 19ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência. Tomar, 2005.
(Portugal)
2005 Milagre I, Rodrigues E, Gama MJ, Lechner MC. Identification of a CCAAT/Enhancer binding protein (C/EBP) responsive region in the proximal promoter of the human CYP46 gene. 19ª Reunião do Grupo de Estudos do Envelhecimento Cerebral e Demência. Tomar, 2005.
(Portugal)
2005 Carvalho AN, Gama MJ, Castro-Caldas M, Rodrigues E, Lechner MC. Effect of in vivo chronic MPTP treatment on mice global gene expression. 19ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência. Tomar, 2005.
(Portugal)
2004 S Bruno, Rodrigues E, Coelho H, Lechner MC. Polymorphism in the CYP2E1 gene: is there a link between environmental and genetic factors in Parkinson's disease?. I Congresso Científico APEF - Farmacogenómica: O Amanhã das Ciências Farmacêuticas. Faculdade de Farmácia da Universidade de Lisboa, Lisboa, 2004
(Portugal)
2004 Gama MJ, Rodrigues E, Pinto Mendes I, Bruno S, Lechner MC. Expression of drug metabolizing enzyme genes in rat brain. Effect of in vivo MPTP treatment. XIV Congresso Nacional de Bioquímica. Vilamoura, 2004.
(Portugal)
2003 Rodrigues E, Vilarem MJ, Maurel P, Lechner MC. Interplay of PXR, RXRa, COUP-TF and CAR in the development-dependent induction of CYP3A1 by synthetic glucocorticoids. EMBO Workshop – Liver Development, Gene Regulation and Disease. Creta, Grécia, 2003.
(Greece)
2003 Rodrigues E. Molecular mechanisms of P450 development-dependent inductive response. Workshop: Detoxication, Molecular Mechanisms and Hepatic Physiopathology. Faculdade de Farmácia da Universidade de Lisboa, Lisboa, 2003,
(Portugal)
2002 Amaral J, Rodrigues E, Garcia C, Lechner MC. NAT2 e susceptibilidade à Doença de Alzheimer: Importância do genótipo NAT2 na degenerescência neuronal. 16ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência. Tomar, 2002.
(Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/09 - Current CYP46A1-dependent regulation of neuronal intracellular traffic (PhD Thesis - Supervisor)
Supervisor
 Pharmacy (PhD)
2021/09/01 - 2022 Restoring cholesterol homeostasis in neurons by cyp46a1 does not stall the progression of Niemann-Pick type c Disease (Master Thesis - Co-supervisor)
Co-supervisor of Joana Pinheiro Leite da Anunciação dos Reis
 Master in Biopharmaceutical Sciences. (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/09 - 2022 New role of PGC-1a2 and PGC-1a3 isoforms in the control of astrocyte phenotype (Master Thesis - Co-supervisor)
Supervisor of Margarida Colaço
 Master in Biopharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020 - 2022 Differential role of PGC-1a Isoforms in the modulation of astrocytes reactive phenotype (Master Thesis - Supervisor)
Supervisor
 Master in Molecular Genetics and Biomedicine (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020 - 2022 Signaling pathways and players activated upon neuronal mitochondrial dysfunction and involved in antioxidant response ¿ Specific role of PGC-1a isoforms. (Master Thesis - Supervisor)
Supervisor
 Master in Biopharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2021/02/02 Therapeutic rescue of Niemman-Pick type C phenotype by CYP46A1 cerebellar ectopic expression (Master Thesis - Supervisor)
Supervisor of Sara Filipa Correia de Brito
 Mestrado em Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 - 2021 Effect of CYP46A1 ectopic expression on recovery from liver disease in a Niemann-Pick type C mouse model (Master Thesis - Supervisor)
Supervisor of Daniela Filipa Portela Risso
 Mestrado em Ciências Biofarmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2020 Unanswered role of cholesterol homeostasis in Parkinson’s Disease (Master Thesis - Supervisor)
Supervisor of Inês de Sousa Caria
 Mestrado em Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2019 Development of a NanoBiT-based celular system to characterize PROTACs in live kinetic assays (Master Thesis - Co-supervisor)
Co-supervisor of Inês Graça Raposo
 Mestrado em Ciências Biofarmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2019 How the lncRNA Zeb2-NAT regulates the expression of Zeb2 (Master Thesis - Co-supervisor)
Co-supervisor of Miguel Francisco Cruz Romano Guedes
 Mestrado em Ciências Biofarmacêuticas, (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2019 Evaluating cortical transcriptomic differences between Alzheimer’s Disease PSEN-1 mutated mouse models and human patients, and their implications in drug development (Master Thesis - Co-supervisor)
Co-supervisor of Sara Rodrigues Mendes
 Mestrado em Ciências Biofarmacêuticas, (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018 Astrocyte-specific Transcriptomic Response to PGC-1a Isoforms. (Master Thesis - Supervisor)
Supervisor of Mariana Messias de Jesus Rufino Ribeiro
 Mestrado em Ciências Biofarmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2017 Epigenetic Regulation of Signalling Pathways in Pancreatic Cancer (Master Thesis - Co-supervisor)
Co-supervisor of Inês Correia da Silva Pires Faleiro
 Mestrado em Ciências Biofarmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2016 Control of neuronal signalling pathways by CYP46A1, an enzyme involved in brain cholesterol homeostasis (PhD Thesis - Supervision)
Supervisor of Miguel Moutinho (SFRH/BD/78041/2011) (currently Post-doc Prof. Gary Landreth, Indiana University
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2015 ER stress in Parkinson’s Disease (Master Thesis - Co-supervisor)
Co-supervisor of Miguel de Almeida Santos
 Mestrado em Ciências BioFarmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2015 Unraveling the neuroprotective role of TUDCA in Parkinson's disease (Master Thesis - Co-supervision)
Co-supervisor of Inês Martins Ribeiro da Fonseca
 Mestrado em Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2015 Histone deacetylase inhibitors as therapeutic agents in cancer: computational and biological studies (Master Thesis - Co-supervisor)
Co-supervisor of Sara Cristina Covas da Silva
 Mestrado em Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2012 Control of CYP46A1 gene expression by transcriptional mechanisms dependent on Sp transcription factors (PhD Thesis - Supervision)
Supervisor of Maria João Nunes (SFRH/BD/41848/2007) (currently Junior Researcher FFUL)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2007 - 2011 Identification of the regulatory mechanisms and factors involved in the brain specific expression of CYP46A1 (PhD Thesis - Supervision)
Supervisor of Inês Milagre da Silva (SFRH/BD/27660/2006) (currently Marie Curie Sklodowska Fellow no IGC)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2020 Avaliação do Sistema Colinérgico na Doença de Alzheimer (PhD Thesis)
(Thesis) Main arguer
 António José Gabriel (PhD)
Universidade de Coimbra, Portugal
2018 Targeting bile acid-activated receptors for preventing non-alcoholic fatty liver disease progression (Master Thesis)
(Thesis) Main arguer
 Md. Mohabbulla Mohib (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 Target S100B to reduce experimental autoimmune encephalomyelitis pathogenesis (Master Thesis)
(Thesis) Main arguer
 Catarina da Silva Barros (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 “Astrocyte-specific Transcriptomic Response to PGC-1a Isoforms (Master Thesis)
Thesis Member
 Mariana Messias de Jesus Rufino Ribeiro (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 Control of neuronal signalling pathways by CYP46A1, an enzyme involved in brain cholesterol homeostasis (PhD Thesis)
Thesis Member
 Miguel Alves Moutinho (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 Understanding chromatin dynamics during antigenic variation in Trypanosoma brucei (PhD Thesis)
Thesis Member
 Francisco Maria dos Santos e Silva Aresta Branco (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2016 Comparação da informação farmacogenética de metabolizadores CYP polimórficos entre US labels e RCMs (Master Thesis)
(Thesis) Main arguer
 Andreia Daniela dos Santos Rodrigues (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 Deciphering the mechanisms underlying the loss of BDNF neuroprotection in an Alzheimer’s Disease model (Master Thesis)
(Thesis) Main arguer
 Sara Luísa Ramalho Tanqueiro, (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2016 Study the function of the newly discovered TrkB receptor fragment (TrkB-ICD) formed by calpain cleavage (Master Thesis)
(Thesis) Main arguer
 João Filipe Fonseca Gomes (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2016 ALS pathogenesis: role of motor neuron-derived exosomes in microglia activation and dysfunction (Master Thesis)
(Thesis) Main arguer
 Sara Filipa Castro da Costa Pinto (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 Modulation of microglia reactivity by S100B in multiple sclerosis (Master Thesis)
(Thesis) Main arguer
 Carla Isabel Silveira Figueiredo (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 Insight on the function of MyT1L in Asc11 mediated neuronal programming (Master Thesis)
(Thesis) Main arguer
 Diogo Miguel Rosa Tomaz (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 Control of CYP46A1 gene expression by transcriptional mechanisms dependent on Sp transcription factors (PhD Thesis)
Thesis Member
 Maria João de Jesus Nunes (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 Somatic expression of the testis-specific PDH2 gene:mechaisms of activation/ silencing (PhD Thesis)
Thesis Member
 Ana Pinheiro (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 Chromatin remodeling in Alzheimer’s Disease Pathogenesis (PhD Thesis)
(Thesis) Main arguer
 Sueli Cristina Ferreira Marques (PhD)
Universidade de Coimbra, Portugal
2011 Apoptosis signaling associated with amyloid ß-induced cellular dysfunction and degeneration. Relevance for Alzheimer's Disease (PhD Thesis)
Thesis Member
 Ricardo Viana (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 Identification of the regulatory mechanisms and factors involved in the brain specific expression of CYP46A1 (PhD Thesis)
Thesis Member
 Inês Milagre da Silva (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 The role os detoxification in the mosquito Anopheles gambiae response to Plasmodium infection (PhD Thesis)
Thesis Member
 Rute Castelo Félix (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2011 Validação funcional de quimeras LEXAdbdGIM em Saccharomyces cerevisiae (Master Thesis)
(Thesis) Arguer
 Ana Fátima Amorim (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 Factores de transcrição artificiais na identificação de genes celulares importantes na infecciosidade do HIV-1 (Master Thesis)
(Thesis) Main arguer
 Joana Borges Pinto (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2007 Role of apoptosis and its modulation in Alzheimer’s disease: insights from in vitro and in vivo studies (PhD Thesis)
Thesis Member
 Rita Ramalho (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Mentoring / Tutoring

Topic Student name
2019 - Current Viviana Ciracci (Post-doctoral fellow) Viviana Ciracci
2019 - 2021 Rita Mendes de Almeida (Post-doctoral fellow) Rita Mendes de Almeida
2014 - 2019 Maria João de Jesus Nunes (SFRH/BPD/95855/2013) (Post-doctoral fellow) Maria João de Jesus Nunes (SFRH/BPD/95855/2013)
2005 - 2006 Molecular mechanisms involved in the transcriptional regulation of the human CYP46 gene - implications in brain cholesterol homeostasis (BI fellow - Supervision) Inês Milagre da Silva
Distinctions

Award

2018 Bolsa de Investigação da Sociedade Portuguesa de Doenças Metabólicas

Other distinction

1997 PhD Scholarship PRAXIS 4/4.1/BD/2999
Fundação para a Ciência e a Tecnologia, Portugal
1993 Erasmus Scholarship (PIC-92-F-1416)