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With a Chemical Engineering background (Instituto Superior Técnico, 1997), Helena L. A. Vieira did her PhD thesis in the fields of Cell Death and Oncobiology at CNRS, France (2002), under the supervision of Guido Kroemer, publishing in Science, Oncogene, JExp Med, Cancer Research and Cell Death Diff. To broaden her expertise, Helena did 3 postdocs in distinct areas: (i) Microbiology (2003), (ii) Biotechnology (2004-2006) and (iii) Neurobiology (2007-2011). In 2007, as a senior postdoc at iBET, she started her own research line, focusing on apoptosis modulation in the Central Nervous System, in particular on carbon monoxide-induced preconditioning and neuroprotection. In the period of 2012-2019, she has been principal investigator at CEDOC, Nova Medical School, Universidade Nova de Lisboa. In 2020, Helena became professor at UCIBIO, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa.____________________________________________________________________________________________________________________ Nowadays, her team is well established in the Carbon monoxide (CO) Scientific Community through studies about the role of CO on cell death, cell metabolism, mitochondrial function, ROS signaling, hypoxia response, preconditioning, neuronal differentiation, neuroinflammation and phagocytosis. Moreover, Helena also has a Translational Research Line in collaboration with the Neurology Service of Centro Hospitalar Lisboa Ocidental (CHLO) with two main purposes: (i) disclosing the mechanisms of remote ischemic conditioning in humans and (ii) identifying new blood biomarkers for stroke diagnostics..___________________________________________________________________________________________________________________ With publications as corresponding author in Redox Biology, Progress in Neurobiology, J CellScience, Mol Neurobiology, J Neurochemistry, J Biological Chemistry, PlosONE, J Physiology, British J Pharmacology. ___________________________________________ 73 peer reviewed publications (48 as first, last or corresponding author) __________________________________________________________ Total number of citations: 10205 (2.02.2024) ______________________________________________________________________________________ H-index: 36 (Scopus)
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Identification

Personal identification

Full name
Helena Luisa de Araujo Vieira

Citation names

  • Vieira, Helena L A

Author identifiers

Ciência ID
CE1F-4B0A-6DBE
ORCID iD
0000-0001-9415-3742
Google Scholar ID
x34GQDIAAAAJ
Scopus Author Id
7003272572

Email addresses

  • hl.vieira@fct.unl.pt (Professional)

Addresses

  • Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 , Caparica, Caparica, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Advanced (C1) Advanced (C1) Upper intermediate (B2) Advanced (C1) Upper intermediate (B2)
Spanish; Castilian Intermediate (B1) Advanced (C1) Beginner (A1) Intermediate (B1) Intermediate (B1)
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2002
Concluded
 Bases Fondamentales de Oncogenese (Docteur)
Université Paris Diderot, France
"“Fonction du translocateur des nucleotides à adenine (ANT) dans l’apoptose”" (THESIS/DISSERTATION)
 Tres Honorable
1992 - 1997
Concluded
 Engenharia Química (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"n/a" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2011 - 2019 Contracted Researcher (Research) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2007 - 2010 Postdoc (Research) Instituto de Biologia Experimental e Tecnológica, Portugal
2004 - 2006 Postdoc (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2003 - 2003 Postdoc (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1999 - 2002 Research Trainee (Research) Université Paris Diderot, France
1998 - 1998 Research Trainee (Research) Centre National de la Recherche Scientifique, France
1997 - 1997 Research Trainee (Research) Universite de Technologie de Compiegne - Centre Benjamin Franklin, France

Teaching in Higher Education

Category
Host institution 		Employer
2020/01 - Current Assistant Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2015 - 2019 Invited Assistant Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2004 - 2007 Invited Assistant Professor (University Teacher) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
Projects

Contract

Designation Funders
2019/10/10 - 2025/10/09 Professore Auxiliar CEEC INstitucional
CEECINST/00102/2018/CP1567/CT0008
10.54499/CEECINST/00102/2018/CP1567/CT0008
Principal investigator
Universidade NOVA de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/01/01 - 2024/12/31 METABOLISM REPROGRAMMING IN NEUROBLASTOMA (NEUROMET)
2022.15035.CBM
Principal investigator
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/10 - 2021/09 Remote ischemic post-conditioning in acute phase of ischemic stroke – disclosing novel circulating biomarkers and clinical trial for improving outcome
PTDC/MEC-NEU/28750/2017
FCT/MEC-NEU/28750/2017
FCT/MEC-NEU/28750/2017
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2014/02/01 - 2016 Mechanisms of cardioprotection by Berries Driven Polyphenols
info:eu-repo/grantAgreement/FCT/3599-PPCDT/135793/PT
Researcher
Instituto de Biologia Experimental e Tecnológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2016 Translational and mechanistic approaches on carbon monoxide as a modulator of neuroinflammation and neuroprotection in glial cells
ANR-FCT/NEU-NMC/0022/2012
ANR-12- ISV5-0001-01
ANR-FCT/NEU-NMC/0022/2012
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2012 Preconditioning triggered by Carbon monoxide: new strategies to prevent brain damage due to hypoxia-ischemia and reperfusion
PTDC/SAU-NEU/089747/2008
PTDC/SAU-NEU/089747/2008
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2012 Chronic Intermittent Eucapnic Hypoxia: systemic effects and evaluation of anti-hypertensive drugs efficacy
PTDC/SAU-TOX/112264/2009
PTDC/SAU-TOX/112264/2009
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007 - 2009 Carbon monoxide as neuroprotector against hypoxia-ischemia and reperfusion
PTDC/SAU-NEU/64327/2006
PTDC/SAU-NEU/64327/2006
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Daniela Dias-Pedroso; Nuno Soares; Helena L. A. Vieira. "Carbon monoxide and energy metabolism". 88-96. United States: Wiley, 2022.
    10.1002/9781119783435.ch4
  2. Ana S. Almeida; Cláudia Figueiredo-Pereira; Helena L. A. Vieira. "Assessment of Mitochondrial Protein Glutathionylation as Signaling for CO Pathway". 249-257. Humana Press, 2021.
    10.1007/978-1-0716-1266-8_19
  3. Wang, Z.; Figueiredo-Pereira, C.; Oudot, C.; Vieira, H.L.A.; Brenner, C.. "Mitochondrion: A Common Organelle for Distinct Cell Deaths?". In International Review of Cell and Molecular Biology, 245-287. Elsevier, 2017.
    10.1016/bs.ircmb.2016.09.010
  4. Carlos C. Romão; Helena L. A. Vieira. "Metal Carbonyl Prodrugs: CO Delivery and Beyond". In CO Delivery and Beyond. WILEY-BLACKWELL, 2015.
  5. Ana S. Almeida; Helena L. A. Vieira; Almeida, Ana S; Vieira, Helena L A; Cláudia S.f. Queiroga; Ana Sofia Cabral E Sousa de Almeida; Cláudia Figueiredo Pereira. "Assessment of mitochondrial protein glutathionylation as signaling for CO pathway". In Methods in Molecular Biology, 343-350. Springer New York, 2015.
    10.1007/978-1-4939-2257-4_30
  6. Romão, Carlos C.; Vieira, Helena L. A.. "Metal Carbonyls for Co-Based Therapies: Challenges and Successes". In Advances in Organometallic Chemistry and Catalysis, 543-561. John Wiley & Sons, Inc., 2013.
    10.1002/9781118742952.ch41
  7. Brenner, Catherine; Marzo, Isabel; de Araujo Vieira, Helena L.; Kroemer, Guido. "Purification and Liposomal Reconstitution of Permeability Transition Pore Complex". In Methods in Enzymology, 243-252. Elsevier, 2000.
    10.1016/s0076-6879(00)22025-9
Journal article
  1. João Pedro Marto; Carvalho AS; Inês Guerra Mollet; Marcelo Mendonça; Manuel Salavisa; Bruna Meira; Marco Fernandes; et al. "Proteomics to Identify New Blood Biomarkers for Diagnosing Patients With Acute Stroke". Journal of the American Heart Association 12 22 (2023): https://novaresearch.unl.pt/en/publications/368304ac-08e7-4afc-b24b-b41f6d4278d4.
    10.1161/JAHA.123.030021
  2. André Carrola; Carlos C. Romão; Helena L. A. Vieira. "Carboxyhemoglobin (COHb): Unavoidable Bystander or Protective Player?". Antioxidants (2023): https://doi.org/10.3390/antiox12061198.
    10.3390/antiox12061198
  3. Marta Machado-Pereira; Alba Grayston; Miguel Garcia-Gabilondo; Vitor Francisco; Ana Cristóvão; João Marto; Helena Vieira; et al. "Retinoic Acid–Loaded Nanoparticles Promote Neurovascular Protection in Stroke". Stroke (2023): https://doi.org/10.1161/STROKEAHA.122.041839.
    10.1161/STROKEAHA.122.041839
  4. Cláudia Figueiredo-Pereira; Beatriz Villarejo-Zori; Pedro C. Cipriano; Diana Tavares; Ignacio Ramírez-Pardo; Patricia Boya; Helena L. A. Vieira. "Carbon Monoxide Stimulates Both Mitophagy And Mitochondrial Biogenesis to Mediate Protection Against Oxidative Stress in Astrocytes". Molecular Neurobiology (2023): https://doi.org/10.1007/s12035-022-03108-7.
    10.1007/s12035-022-03108-7
  5. Inês Guerra Mollet; Catarina Martins; Miguel Ângelo-Dias; Carvalho AS; Kerman Aloria; Rune Matthiesen; M Viana-Baptista; LUIS MIGUEL BORREGO; Helena L. A. Vieira. "Pilot study in human healthy volunteers on the mechanisms underlying remote ischemic conditioning (RIC) – Targeting circulating immune cells and immune-related proteins". Journal of Neuroimmunology 367 (2022): https://novaresearch.unl.pt/en/publications/79ebfba3-7d0d-4751-be20-4013611d67f3.
    10.1016/j.jneuroim.2022.577847
  6. Manuela Morleo; Helena L. A. Vieira; Petra Pennekamp; Alessandro Palma; Liliana Lopes, Liliana Bento-Lopes; Heymut Omran; susana santos lopes; Duarte C. Barral; Brunella Franco. "Crosstalk between cilia and autophagy". Autophagy (2022): 1-20. https://novaresearch.unl.pt/en/publications/f366ff3f-e507-43a1-9794-5fd9a3c7f3e0.
    10.1080/15548627.2022.2067383
  7. Daniela Dias-Pedroso; José S. Ramalho; Vilma A. Sardão; John G. Jones; Carlos C. Romão; Paulo J. Oliveira; Helena L.A. Vieira. "Carbon Monoxide-Neuroglobin Axis Targeting Metabolism Against Inflammation in BV-2 Microglial Cells". Molecular Neurobiology (2022): https://doi.org/10.1007/s12035-021-02630-4.
    10.1007/s12035-021-02630-4
  8. Inês Mollet; João Pedro Marto; Marcelo Mendonça; Miguel Viana Baptista; Helena L. A. Vieira. "Remote but not Distant: a Review on Experimental Models and Clinical Trials in Remote Ischemic Conditioning as Potential Therapy in Ischemic Stroke". Molecular Neurobiology 59 1 (2022): 294-325. https://doi.org/10.1007/s12035-021-02585-6.
    10.1007/s12035-021-02585-6
  9. Nuno L. Soares; Inês Paiva; Joana Bravo; Cláudia S. F. Queiroga; Bernadete F. Melo; Silvia V Conde; Carlos C. Romão; Teresa Summavielle; Helena L. A. Vieira. "Carbon Monoxide Modulation of Microglia-Neuron Communication: Anti-Neuroinflammatory and Neurotrophic Role". Molecular Neurobiology (2021): https://novaresearch.unl.pt/en/publications/2647604e-d379-4cb3-85e8-43c5f0b11e74.
    10.1007/s12035-021-02643-z
  10. Figueiredo-Pereira, Cláudia; Dias-Pedroso, Daniela; Soares, Nuno L.; Vieira, Helena L.A.. "CO-mediated cytoprotection is dependent on cell metabolism modulation". Redox Biology 32 (2020): 101470. http://dx.doi.org/10.1016/j.redox.2020.101470.
    10.1016/j.redox.2020.101470
  11. Oliveira, Sara R.; Castelhano, João; Sereno, José; Vieira, Helena L.A.; Duarte, Carlos B.; Castelo-Branco, Miguel. "Response of the cerebral vasculature to systemic carbon monoxide administration – regional differences and sexual dimorphism". European Journal of Neuroscience (2020): http://dx.doi.org/10.1111/ejn.14725.
    10.1111/ejn.14725
  12. Ines Rosignol; Beatriz Villarejo-Zori; Petra Teresak; Elena Sierra-Filardi; Xandra Pereiro; Natalia Rodríguez-Muela; Elena Vecino; et al. "The mito-QC reporter for quantitative mitophagy assessment in primary retinal ganglion cells and experimental glaucoma models". International Journal of Molecular Sciences 21 5 (2020): https://novaresearch.unl.pt/en/publications/5b748fcf-270b-4756-9abc-7f200299b112.
    10.3390/ijms21051882
  13. Daniel Noronha Osório; Ricardo Viana-Soares; João Pedro Marto; Marcelo D. Mendonça; Hugo P. Silva; Cláudia Quaresma; Miguel Viana-Baptista; Hugo Gamboa; Helena L. A. Vieira. "Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment". BMC Cardiovascular Disorders (2019): https://doi.org/10.1186/s12872-019-1181-5.
    10.1186/s12872-019-1181-5
  14. Cláudia Figueiredo-Pereira; Regina Menezes; Sofia Ferreira; Cláudia N Santos; Helena L A Vieira. "Carbon monoxide released by CORM-A1 prevents yeast cell death via autophagy stimulation". FEMS Yeast Research 19 5 (2019): https://doi.org/10.1093/femsyr/foz051.
    10.1093/femsyr/foz051
  15. Oudot, Carole; Gomes, Andreia; Nicolas, Valérie; Le Gall, Morgane; Chaffey, Philippe; Broussard, Cédric; Calamita, Giuseppe; et al. "CSRP3 mediates polyphenols-induced cardioprotection in hypertension". The Journal of Nutritional Biochemistry 66 (2019): 29-42. http://dx.doi.org/10.1016/j.jnutbio.2019.01.001.
    10.1016/j.jnutbio.2019.01.001
  16. Dias-Pedroso, Daniela; Guerra, Joel; Gomes, Andreia; Oudot, Carole; Brenner, Catherine; Santos, Cláudia N.; Vieira, Helena L. A.. "Phenolic Metabolites Modulate Cardiomyocyte Beating in Response to Isoproterenol". Cardiovascular Toxicology (2018): http://dx.doi.org/10.1007/s12012-018-9485-8.
    10.1007/s12012-018-9485-8
  17. Santos, Claudia N.; Gomes, Andreia; Oudot, Carole; Dias-Pedroso, Daniela; Rodriguez-Mateos, Ana; Vieira, Helena L.A.; Brenner, Catherine. "Pure Polyphenols Applications for Cardiac Health and Disease". Current Pharmaceutical Design 24 19 (2018): 2137-2156. http://dx.doi.org/10.2174/1381612824666180608102344.
    10.2174/1381612824666180608102344
  18. Oliveira, Sara R.; Figueiredo-Pereira, Cláudia; Duarte, Carlos B.; Vieira, Helena L. A.. "P2X7 Receptors Mediate CO-Induced Alterations in Gene Expression in Cultured Cortical Astrocytes—Transcriptomic Study". Molecular Neurobiology (2018): http://dx.doi.org/10.1007/s12035-018-1302-7.
    10.1007/s12035-018-1302-7
  19. Almeida, Ana S.; Soares, Nuno L.; Sequeira, Catarina O.; Pereira, Sofia A.; Sonnewald, Ursula; Vieira, Helena L.A.. "Improvement of neuronal differentiation by carbon monoxide: Role of pentose phosphate pathway". Redox Biology 17 (2018): 338-347. http://dx.doi.org/10.1016/j.redox.2018.05.004.
    10.1016/j.redox.2018.05.004
  20. Dreyer-Andersen, Nanna; Almeida, Ana Sofia; Jensen, Pia; Kamand, Morad; Okarmus, Justyna; Rosenberg, Tine; Friis, Stig Düring; et al. "Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells". PLOS ONE 13 1 (2018): e0191207. http://dx.doi.org/10.1371/journal.pone.0191207.
    10.1371/journal.pone.0191207
  21. Wilson, Jayne Louise; Bouillaud, Frédéric; Almeida, Ana S.; Vieira, Helena L.; Ouidja, Mohand Ouidir; Dubois-Randé, Jean-Luc; Foresti, Roberta; Motterlini, Roberto. "Carbon monoxide reverses the metabolic adaptation of microglia cells to an inflammatory stimulus". Free Radical Biology and Medicine 104 (2017): 311-323. http://dx.doi.org/10.1016/j.freeradbiomed.2017.01.022.
    10.1016/j.freeradbiomed.2017.01.022
  22. Almeida, Ana S.; Vieira, Helena L. A.. "Role of Cell Metabolism and Mitochondrial Function During Adult Neurogenesis". Neurochemical Research 42 6 (2016): 1787-1794. http://dx.doi.org/10.1007/s11064-016-2150-3.
    10.1007/s11064-016-2150-3
  23. Pedroso, Daniela; Nunes, Ana R.; Diogo, Lucília N.; Oudot, Carole; Monteiro, Emília C.; Brenner, Catherine; Vieira, Helena L.A.. "Hippocampal neurogenesis response: What can we expect from two different models of hypertension?". Brain Research 1646 (2016): 199-206. http://dx.doi.org/10.1016/j.brainres.2016.05.044.
    10.1016/j.brainres.2016.05.044
  24. Queiroga, Cláudia S. F.; Alves, Raquel M. A.; Conde, Sílvia V.; Alves, Paula M.; Vieira, Helena L. A.. "Paracrine effect of carbon monoxide – astrocytes promote neuroprotection through purinergic signaling in mice". Journal of Cell Science 129 16 (2016): 3178-3188. http://dx.doi.org/10.1242/jcs.187260.
    10.1242/jcs.187260
  25. Almeida, Ana S.; Sonnewald, Ursula; Alves, Paula M.; Vieira, Helena L.A.. "Carbon monoxide improves neuronal differentiation and yield by increasing the functioning and number of mitochondria". Journal of Neurochemistry 138 3 (2016): 423-435. http://dx.doi.org/10.1111/jnc.13653.
    10.1111/jnc.13653
  26. Almeida, Ana S.; Soares, Nuno L.; Vieira, Melissa; Gramsbergen, Jan Bert; Vieira, Helena L. A.. "Carbon Monoxide Releasing Molecule-A1 (CORM-A1) Improves Neurogenesis: Increase of Neuronal Differentiation Yield by Preventing Cell Death". PLOS ONE 11 5 (2016): e0154781. http://dx.doi.org/10.1371/journal.pone.0154781.
    10.1371/journal.pone.0154781
  27. Klionsky, Daniel J; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Acevedo Arozena, Abraham; Adachi, Hiroaki; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy 12 1 (2016): 1-222. http://dx.doi.org/10.1080/15548627.2015.1100356.
    10.1080/15548627.2015.1100356
  28. R. Oliveira, Sara; Queiroga, Cláudia S. F.; Vieira, Helena L. A.; Vieira, Helena L A. "Mitochondria and carbon monoxide: cytoprotection and control of cell metabolism - a role for Ca2+?". The Journal of Physiology 594 15 (2015): 4131-4138. http://dx.doi.org/10.1113/jp270955.
    10.1113/jp270955
  29. Oliveira, Sara R.; Vieira, Helena L.A.; Duarte, Carlos B.. "Effect of carbon monoxide on gene expression in cerebrocortical astrocytes: Validation of reference genes for quantitative real-time PCR". Nitric Oxide 49 (2015): 80-89. http://dx.doi.org/10.1016/j.niox.2015.07.003.
    10.1016/j.niox.2015.07.003
  30. Almeida, Ana S.; Figueiredo-Pereira, Cláudia; Vieira, Helena L. A.. "Carbon monoxide and mitochondria: modulation of cell metabolism, redox response and cell death". Frontiers in Physiology 6 (2015): http://dx.doi.org/10.3389/fphys.2015.00033.
    10.3389/fphys.2015.00033
  31. Vieira, Helena L A; Mauro-Lizcano, Marta; Esteban-Martínez, Lorena; Seco, Esther; Serrano-Puebla, Ana; Garcia-Ledo, Lucia; Figueiredo-Pereira, Cláudia; Vieira, Helena L A; Boya, Patricia. "New method to assess mitophagy flux by flow cytometry". Autophagy 11 5 (2015): 833-843. http://dx.doi.org/10.1080/15548627.2015.1034403.
    10.1080/15548627.2015.1034403
  32. Queiroga C; Almeida A; Tomasi S; Vercelli A; Paula P; Vieira H. "Unravelling carbon monoxide protection in cerebral ischemia: from the organelle to the organism.". SpringerPlus (2015): http://europepmc.org/abstract/med/27386189.
    10.1186/2193-1801-4-s1-l26
  33. Oliveira S; Vieira H; Duarte C. "Validation of astrocytic reference genes for qRT-PCR in CO treatment studies.". SpringerPlus (2015): http://europepmc.org/abstract/PMC/PMC4796674.
  34. Queiroga, Cláudia S F; Vercelli, Alessandro; Vieira, Helena L A; Vieira, Helena L A. "Carbon monoxide and the CNS: challenges and achievements". British Journal of Pharmacology 172 6 (2014): 1533-1545. http://dx.doi.org/10.1111/bph.12729.
    10.1111/bph.12729
  35. Queiroga, Cláudia S. F.; Tomasi, Simone; Widerøe, Marius; Alves, Paula M.; Vercelli, Alessandro; Vieira, Helena L. A.. "Preconditioning Triggered by Carbon Monoxide (CO) Provides Neuronal Protection Following Perinatal Hypoxia-Ischemia". PLoS ONE 7 8 (2012): e42632. http://dx.doi.org/10.1371/journal.pone.0042632.
    10.1371/journal.pone.0042632
  36. Tavares, Lucélia; Figueira, Inês; Macedo, Diana; McDougall, Gordon J.; Leitão, Maria Cristina; Vieira, Helena L.A.; Stewart, Derek; et al. "Neuroprotective effect of blackberry (Rubus sp.) polyphenols is potentiated after simulated gastrointestinal digestion". Food Chemistry 131 4 (2012): 1443-1452. http://dx.doi.org/10.1016/j.foodchem.2011.10.025.
    10.1016/j.foodchem.2011.10.025
  37. Ana Sofia Cabral e Sousa de Almeida; Cláudia S.F. Queiroga; Marcos F Q Sousa; Alves PM; Helena L. A. Vieira. "Carbon monoxide modulates apoptosis by reinforcing oxidative metabolism in astrocytes: role of BCL-2.". Journal of Biological Chemistry 287 14 (2012): 10761-10770. https://research.unl.pt/en/publications/carbon-monoxide-modulates-apoptosis-by-reinforcing-oxidative-metabolism-in-astrocytes-role-of-bcl2(308d4a76-3dc9-44bc-81b3-cfd325b0084c).html.
    10.1074/jbc.M111.306738
  38. Tavares, Lucélia; Figueira, Inês; McDougall, Gordon J.; Vieira, Helena L. A.; Stewart, Derek; Alves, Paula M.; Ferreira, Ricardo B.; Santos, Cláudia N.. "Neuroprotective effects of digested polyphenols from wild blackberry species". European Journal of Nutrition 52 1 (2012): 225-236. http://dx.doi.org/10.1007/s00394-012-0307-7.
    10.1007/s00394-012-0307-7
  39. Queiroga, Cláudia S. F.; Almeida, Ana S.; Vieira, Helena L. A.. "Carbon Monoxide Targeting Mitochondria". Biochemistry Research International 2012 (2012): 1-9. http://dx.doi.org/10.1155/2012/749845.
    10.1155/2012/749845
  40. Vieira, Helena L.A.; Alves, Paula M.; Vercelli, Alessandro. "Modulation of neuronal stem cell differentiation by hypoxia and reactive oxygen species". Progress in Neurobiology 93 3 (2011): 444-455. http://dx.doi.org/10.1016/j.pneurobio.2011.01.007.
    10.1016/j.pneurobio.2011.01.007
  41. Queiroga, Cláudia SF; Almeida, Ana S; Alves, Paula M; Brenner, Catherine; Vieira, Helena LA. "Carbon monoxide prevents hepatic mitochondrial membrane permeabilization". BMC Cell Biology 12 1 (2011): 10. http://dx.doi.org/10.1186/1471-2121-12-10.
    10.1186/1471-2121-12-10
  42. Vieira, Helena L. A.; Pereira, Ana C. P.; Peixoto, Cristina C.; Moraes, Roberto H. P.; Alves, Paula M.; Mendonça, Ronaldo Z.. "Improvement of recombinant protein production by an anti-apoptotic protein from hemolymph of Lonomia obliqua". Cytotechnology 62 6 (2010): 547-555. http://dx.doi.org/10.1007/s10616-010-9305-x.
    10.1007/s10616-010-9305-x
  43. Queiroga, Cláudia S. F.; Almeida, Ana S.; Martel, Cécile; Brenner, Catherine; Alves, Paula M.; Vieira, Helena L. A.. "Glutathionylation of Adenine Nucleotide Translocase Induced by Carbon Monoxide Prevents Mitochondrial Membrane Permeabilization and Apoptosis". Journal of Biological Chemistry 285 22 (2010): 17077-17088. http://dx.doi.org/10.1074/jbc.m109.065052.
    10.1074/jbc.m109.065052
  44. Bannenberg, Gerard L; Vieira, Helena LA. "Therapeutic applications of the gaseous mediators carbon monoxide and hydrogen sulfide". Expert Opinion on Therapeutic Patents 19 5 (2009): 663-682. http://dx.doi.org/10.1517/13543770902858824.
    10.1517/13543770902858824
  45. Vieira, Helena L.A.; Cunha, Liliana; Goldmacher, Victor S.; Alves, Paula M.. "The effect of the cell death suppressor vMIA on the production of a recombinant protein in the adenovirus-293 expression system". Protein Expression and Purification 64 2 (2009): 179-184. http://dx.doi.org/10.1016/j.pep.2008.11.004.
    10.1016/j.pep.2008.11.004
  46. Vieira, Helena L. A.; Queiroga, Cláudia S. F.; Alves, Paula M.. "Pre-conditioning induced by carbon monoxide provides neuronal protection against apoptosis". Journal of Neurochemistry 107 2 (2008): 375-384. http://dx.doi.org/10.1111/j.1471-4159.2008.05610.x.
    10.1111/j.1471-4159.2008.05610.x
  47. Roldão, António; Vieira, Helena L.A.; Charpilienne, Annie; Poncet, Didier; Roy, Polly; Carrondo, Manuel J.T.; Alves, Paula M.; Oliveira, R.. "Modeling rotavirus-like particles production in a baculovirus expression vector system: Infection kinetics, baculovirus DNA replication, mRNA synthesis and protein production". Journal of Biotechnology 128 4 (2007): 875-894. http://dx.doi.org/10.1016/j.jbiotec.2007.01.003.
    10.1016/j.jbiotec.2007.01.003
  48. Vieira, Helena L. A.; Pereira, Ana C. P.; Carrondo, Manuel J. T.; Alves, Paula M.. "Catalase effect on cell death for the improvement of recombinant protein production in baculovirus-insect cell system". Bioprocess and Biosystems Engineering 29 5-6 (2006): 409-414. http://dx.doi.org/10.1007/s00449-006-0093-9.
    10.1007/s00449-006-0093-9
  49. António Roldão; Helena L. A. Vieira; Alves PM; Rui Manuel Freitas Oliveira; Manuel J T Carrondo. "Intracellular dynamics in rotavirus-like particles production: Evaluation of multigene and monocistronic infection strategies". Process Biochemistry 41 10 (2006): 2188-2199. https://research.unl.pt/en/publications/intracellular-dynamics-in-rotaviruslike-particles-production-evaluation-of-multigene-and-monocistronic-infection-strategies(1ae0def9-3466-4a90-a525-bf52e9d3c5d7).html.
    10.1016/j.procbio.2006.06.019
  50. Freire, Patrick; Vieira, Helena L.A.; Furtado, Ana R.; de Pedro, Miguel A.; Arraiano, Cecília M.. "Effect of the morphogenebolAon the permeability of theEscherichia coliouter membrane". FEMS Microbiology Letters 260 1 (2006): 106-111. http://dx.doi.org/10.1111/j.1574-6968.2006.00307.x.
    10.1111/j.1574-6968.2006.00307.x
  51. Roldão, A.; Vieira, H.L.A.; Carrondo, M.J.T.; Alves, P.M.; Oliveira, R.. "Rotavirus-like particle production: Simulation of protein production and particle assembly". Computer Aided Chemical Engineering 21 C (2006): 1673-1678. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956742564&partnerID=MN8TOARS.
    10.1016/S1570-7946(06)80288-9
  52. Vieira, Helena L.A.; Estêvão, Catarina; Roldão, António; Peixoto, Cristina C.; Sousa, Marcos F.Q.; Cruz, Pedro E.; Carrondo, Manuel J.T.; Alves, Paula M.. "Triple layered rotavirus VLP production: Kinetics of vector replication, mRNA stability and recombinant protein production". Journal of Biotechnology 120 1 (2005): 72-82. http://dx.doi.org/10.1016/j.jbiotec.2005.03.026.
    10.1016/j.jbiotec.2005.03.026
  53. Vieira, H. L. A.; Freire, P.; Arraiano, C. M.; Vieira, H.L.A.; Arraiano, C.M.. "Effect of Escherichia coli Morphogene bolA on Biofilms". Applied and Environmental Microbiology 70 9 (2004): 5682-5684. http://dx.doi.org/10.1128/aem.70.9.5682-5684.2004.
    10.1128/aem.70.9.5682-5684.2004
  54. Boya, Patricia; Gonzalez-Polo, Rosa-Ana; Poncet, Delphine; Andreau, Karine; Vieira, Helena LA; Roumier, Thomas; Perfettini, Jean-Luc; Kroemer, Guido. "Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine". Oncogene 22 25 (2003): 3927-3936. http://dx.doi.org/10.1038/sj.onc.1206622.
    10.1038/sj.onc.1206622
  55. Belzacq, A-S; Vieira, H LA; Verrier, F; Vandecasteele , G; Cohen, I; Prevost, MC; Brenner, C; et al. "Bcl-2 and Bax Modulate Adenine Nucleotide Translocase Activity". Cancer Research 63 2 (2003): 541-546. http://cancerres.aacrjournals.org/content/canres/63/2/541.full.pdf.
    Published
  56. Vieira, H.; Kroemer, G.. "Mitochondria as Targets of Apoptosis Regulation by Nitric Oxide". IUBMB Life 55 10-11 (2003): 613-616. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346991918&partnerID=MN8TOARS.
    10.1080/15216540310001639652
  57. Roumier, T; Vieira, H LA; Castedo, M; Ferri, K F; Boya, P; Andreau, K; Druillennec, S; et al. "The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway". Cell Death & Differentiation 9 11 (2002): 1212-1219. http://dx.doi.org/10.1038/sj.cdd.4401089.
    10.1038/sj.cdd.4401089
  58. Boya, P; Cohen, I; Zamzami, N; Vieira, H L A; Kroemer, G. "Endoplasmic reticulum stress-induced cell death requires mitochondrial membrane permeabilization". Cell Death & Differentiation 9 4 (2002): 465-467. http://dx.doi.org/10.1038/sj.cdd.4401006.
    10.1038/sj.cdd.4401006
  59. Belzacq, A.-S.; Vieira, H.L.A.; Kroemer, G.; Brenner, C.. "The adenine nucleotide translocator in apoptosis". Biochimie 84 2-3 (2002): 167-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036478993&partnerID=MN8TOARS.
    10.1016/S0300-9084(02)01366-4
  60. Vieira, H.L.A.; Boya, P.; Cohen, I.; El Hamel, C.; Haouzi, D.; Druillenec, S.; Belzacq, A.-S.; et al. "Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-XL". Oncogene 21 13 (2002): 1963-1977. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037150242&partnerID=MN8TOARS.
    10.1038/sj/onc/1205270
  61. Haouzi, D.; Cohen, I.; Vieira, H.L.A.; Poncet, D.; Boya, P.; Castedo, M.; Vadrot, N.; et al. "Mitochondrial permeability transition as a novel principle of hepatorenal toxicity in vivo". Apoptosis 7 5 (2002): 395-405. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036792660&partnerID=MN8TOARS.
    10.1023/A:1020026923038
  62. Belzacq, Anne-Sophie; El Hamel, Chahrazed; Vieira, Helena L A; Cohen, Isabel; Haouzi, Delphine; Métivier, Didier; Marchetti, Philippe; et al. "Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437". Oncogene 20 52 (2001): 7579-7587. http://dx.doi.org/10.1038/sj.onc.1204953.
    10.1038/sj.onc.1204953
  63. Vieira, Helena LA; Belzacq, Anne-Sophie; Haouzi, Delphine; Bernassola, Francesca; Cohen, Isabel; Jacotot, Etienne; Ferri, Karine F; et al. "The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite and 4-hydroxynonenal". Oncogene 20 32 (2001): 4305-4316. http://dx.doi.org/10.1038/sj.onc.1204575.
    10.1038/sj.onc.1204575
  64. Jacotot, Etienne; Ferri, Karine F.; El Hamel, Chahrazed; Brenner, Catherine; Druillennec, Sabine; Hoebeke, Johan; Rustin, Pierre; et al. "Control of Mitochondrial Membrane Permeabilization by Adenine Nucleotide Translocator Interacting with HIV-1 Viral Protein R and Bcl-2". The Journal of Experimental Medicine 193 4 (2001): 509-520. http://dx.doi.org/10.1084/jem.193.4.509.
    Open access • 10.1084/jem.193.4.509
  65. Belzacq, Anne-Sophie; Jacotot, Etienne; Vieira, Helena; Mistro, D.; Granville, D.J.; Xie, Zhihua; Reed, John C; et al. "Apoptosis Induction by the Photosensitizer Verteporfin: Identification of Mitochondrial Adenine Nucleotide Translocator as a Critical Target". Cancer Research 61 4 (2001): 1260-1264. http://cancerres.aacrjournals.org/content/61/4/1260.full-text.pdf.
  66. Vieira, H L A; Haouzi, D; El Hamel, C; Jacotot, E; Belzacq, A-S; Brenner, C; Kroemer, G. "Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator". Cell Death & Differentiation 7 12 (2000): 1146-1154. http://dx.doi.org/10.1038/sj.cdd.4400778.
    10.1038/sj.cdd.4400778
  67. Zamzami, Naoufal; Hamel, Chahrazed El; Maisse, Carine; Brenner, Catherine; Muñoz-Pinedo, Cristina; Belzacq, Anne-Sophie; Costantini, Paola; et al. "Bid acts on the permeability transition pore complex to induce apoptosis". Oncogene 19 54 (2000): 6342-6350. http://dx.doi.org/10.1038/sj.onc.1204030.
    10.1038/sj.onc.1204030
  68. Jacotot, Etienne; Ravagnan, Luigi; Loeffler, Markus; Ferri, Karine F.; Vieira, Helena L.A.; Zamzami, Naoufal; Costantini, Paola; et al. "The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore". The Journal of Experimental Medicine 191 1 (2000): 33-46. http://dx.doi.org/10.1084/jem.191.1.33.
    10.1084/jem.191.1.33
  69. Brenner C; Cadiou H; Vieira HL; Zamzami N; Marzo I; Xie Z; Leber B; et al. "Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator.". Oncogene 19 3 (2000): 329-336. http://europepmc.org/abstract/med/10656679.
    10.1038/sj.onc.1203298
  70. Costantini, P.; Belzacq, A.-S.; Vieira, H.L.A.; Larochette, N.; De Pablo, M.A.; Zamzami, N.; Susin, S.A.; et al. "Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis". Oncogene 19 2 (2000): 307-314. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034642510&partnerID=MN8TOARS.
    10.1038/sj.onc.1203299
  71. Vieira, H. L. A.; Kroemer, G.. "Pathophysiology of mitochondrial cell death control". Cellular and Molecular Life Sciences (CMLS) 56 11-12 (1999): 971-976. http://dx.doi.org/10.1007/s000180050486.
    10.1007/s000180050486
  72. Marzo, I.. "Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis". Science 281 5385 (1998): 2027-2031. http://dx.doi.org/10.1126/science.281.5385.2027.
    10.1126/science.281.5385.2027
  73. Brenner, C.; Marzo, I.; Zamzami, N.; Susin, S.A.; Vieira, H.L.A.; Kroemer, G.. "Coopération mortelle entre la protéine pro-apoptotique Bax et le translocateur àadénine nucléotide pour le contrôle mitochondrial de l'apoptose". Medecine/Sciences 14 12 (1998): 1399-1401. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745530976&partnerID=MN8TOARS.
Preprint
  1. Sara R. Oliveira; João Castelhano; José Sereno; Lorena Petrella; Miguel Castelo-Branco; Helena L. A. Vieira; Carlos B. Duarte. "Pilot MRI study of carbon monoxide (CO) against ischemic stroke in mice: blood brain barrier integrity and metabolic pattern". 2022. https://doi.org/10.1101/2022.11.10.515956.
    10.1101/2022.11.10.515956

Other

Other output
  1. Carbon monoxide modulation of microglia-neuron communication. Anti- Neuroinflammatory and neurotrophic role. 2023. I Paiva; N Soares; J Bravo; C Queiroga; B Melo; Silvia V Conde; Carlos C. Romão; TT Summavielle; Helena L. A. Vieira. https://novaresearch.unl.pt/en/publications/074373ea-d929-49bf-970a-1503b5b72199.
  2. Anti-inflammatory effect of carbon monoxide on the neuron-microglia communication. 2019. N. Soares; C. Queiroga; Helena L. A. Vieira. https://novaresearch.unl.pt/en/publications/bc86c847-f04d-4182-9195-83cc369834b4.
  3. Selective mitochondrial autophagy as key pathway for carbon monoxide cytoprotection. 2019. C. Pereira; Helena L. A. Vieira. https://novaresearch.unl.pt/en/publications/cd9e4e9f-e508-4405-8f22-36c55006f783.
  4. Carbon monoxide-Neuroglobin axis on cytoprotection. 2019. D. Dias-Pedroso; Helena L. A. Vieira. https://novaresearch.unl.pt/en/publications/891bb7b2-cf2c-4077-bbcd-0cea512a62fd.
  5. Human bioavailable berries-driven polyphenol metabolites improve cardiomyocyte beating: role of mitochondria, ROS and Ca2+ signaling. 2016. Daniela Pedroso; J Guerra; A Gomes; Carole Oudot; Catherine Brenner; C N Santos; Helena L. A. Vieira. https://novaresearch.unl.pt/en/publications/b8c0ccae-1147-4db0-a4cb-ac5a83f8a6b6.
  6. Validation of astrocytic reference genes for qRT-PCR in CO treatment studies. 2015. Sara Oliveira; Helena L. A. Vieira; Carlos Duarte. https://novaresearch.unl.pt/en/publications/73b46c30-5ef0-46d9-880c-6f9b5b8625f2.
    10.1186/2193-1801-4-S1-P32
  7. Exogenous carbon monoxide improves neuronal differentiation: a near-death experience. 2015. Ana S. Almeida; Melissa Vieira; Diogo Fortunato; Helena L. A. Vieira. https://novaresearch.unl.pt/en/publications/4bc81192-8858-4b21-80b1-b1ce25539602.
    10.1186/2193-1801-4-S1-P9
  8. CARBON MONOXIDE PREVENTS NEURONAL APOPTOSIS BY ASTROCYTIC METABOLISM MODULATION: PURINERGIC SIGNALLING. 2011. C. S. Queiroga; R. M. Alves; Silvia V Conde; E.C. Monteiro; Alves PM; Helena L. A. Vieira. https://novaresearch.unl.pt/en/publications/d11446d2-3d36-4e74-a7fb-f7aa8e1abf93.
  9. CARBON MONOXIDE IN NEURONAL DIFFERENTIATION - NOVEL APPROACHES FOR CELL THERAPIES APPLICATIONS. 2011. Ana Sofia Almeida; Alves PM; Helena L. A. Vieira. https://novaresearch.unl.pt/en/publications/400c54e5-8cc0-4bfb-aa1d-69b62ade63f1.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/02/23 Carbon monoxide targeting mitochondria in CNS: cell energy and fate control Seminar at Neuroscience Institute Cavalieri Ottolenghi
Neuroscience Institute Cavalieri Ottolenghi (Torino)
2023/11/30 Carbon monoxide promotes mitochondrial homeostasis in astrocytes and microglia: effect on mitophagy, mitochondrial biogenesis and mitochondrial metabolism Mitochondria in Aging, Cancer and Cell death Meeting MAC 2023
MAC (Coimbra, Portugal)
2022/03/22 Carbon monoxide (CO) modulates cell metabolism implication on neuronal differentiation, anti-inflammation role and prevention of cell death Invited seminar
Institut Gustave Roussy (Paris, France)
2022/01/11 CO-mediated cytoprotection is dependent on cell metabolism modulation – implication on neuronal differentiation, anti-inflammation role and prevention of cell death BenBedPhar Online Scientific Marathon - COST Action meeting
COST Action (online meeting, Spain)
2021/10/19 Carbon monoxide targets mitochondria and modulates cell metabolism in brain cell Invited seminar
TIGEM (Nápoles, Italy)
2019/09 Mitochondrial quality control as key process for carbon monoxide-induced cytoprotection Worshop Lysocil Lysosomes (dys)function
Lysocil Twining (Portugal)
2019/07 Carbon monoxide modulation of cell metabolism, mitochondrial function and ROS signalling during adult neurogenesis Redox signalling in physiology, ageing and disease
Biochemical Society (Newcastle, United Kingdom)
2016/04 Human bioavailable berries-driven polyphenol metabolites improve cardiomyocyte beating: role of mitochondria, ROS and Ca2+ signaling 50th Annual Scientific Meeting of European Society for Clinical Investigation
European Society for Clinical Investigation (Paris, France)
2015/07 Gaseous regulation of Ca2+ homeostasis; for better or worse? Carbon monoxide and mitochondria: modulation of cell metabolism and cell death Physiology Society Meeting 2015
Physiology Society (Cardiff, United Kingdom)
2015/06 Carbon monoxide: signaling, neuroprotection and modulation of inflammation European Society for Neurochemistry 2015 - Molecular Mechanisms of Regulation in the Nervous System
European Society of Neurochemistry (Tartu, Estonia)
2015/05 Carbon monoxide and mitochondria: modulation of cell metabolism, redox response and cell death ENOG Gasotransmitters: from basic science to therapeutic applications
COST Action 1005 (Atenas, Greece)
2013/04 Carbon monoxide prevents neuronal apoptosis by modulating astrocytic metabolism – a non cell autonomous effect Meeting of ENOG: European Network on Gasotransmitters
COST Action 1005 ENOG (Smolenice, Slovakia)
2012/01 Preconditioning triggered by carbon monoxide: new strategies to prevent brain damage due to hypoxia-ischemia and reperfusion - in vitro approaches to in vivo applicability Meeting of ENOG: European Network on Gasotransmitters
COST Action ENOG 1005 (Madrid, Spain)
2011/08 Preconditioning triggered by carbon monoxide: new strategies to prevent brain damage due to hypoxia-ischemia and reperfusion - in vitro and in vivo approaches International Society for Neurochemistry Meeting
International Society of Neurochemistry (Atenas, Greece)
2007/05 Carbon Monoxide as a new protector against neuronal apoptosis ESN Meeting-3rd Conference on Advances in Molecular Mechanisms of Neurological Disorders
European Society of Neurochemistry (Salamanca, Spain)
2004/11 Stoicheometry and kinetics of production of viral proteins and assembly into VLP’s: tools for improved vector design Third Recombinant Protein Meeting: A comparative view on host physiology
(Tavira, Portugal)
2000/03 Bcl-2 and Bax Regulate the Channel Activity of the Mitochondrial Adenine Nucleotide Translocator Expression and Regulation of Mitochondrial Oxidative Phosphorylation and Disordes in Human Pathology, FEBS Advances Course
FEBS (Bari, Italy)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - Current Neuroprotective role of carboxyhemoglobin (COHb) against stroke
Supervisor
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023 - Current The role of peroxisomal function in CO modulation of neuroinflammation
Supervisor
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023 - Current Differential Stroke Diagnostics at point of care based Surfaced Enhanced Raman Spectroscopy (SERS) analysis
Supervisor
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - Current Early Diagnosis and Complications of Acute Ischemic Stroke
Co-supervisor
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022 - 2023 The role of glutathione signaling in mitophagy induced by oxidative stress: cytoprotective role in neurons and astrocytes?
Supervisor
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 - 2023 Carbon monoxide-mediated pro-regenerative and non-inflammatory microglial phagocytosis of dead neurons – role of CO in microglial engulfment of neurons
Supervisor
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 - 2023 Protective role of carboxyhemoglobin (COHb) on blood brain barrier (BBB) integrity
Supervisor
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021 - 2022 The role of glutathione signaling in mitophagy induced by oxidative stress: cytoprotective role in stroke?
Supervisor
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2021 - 2022 Carbon monoxide-mediated pro-regenerative and non-inflammatory microglial phagocytosis: towards clearance of dead neurons
Supervisor
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021 - 2022 Remote ischemic conditioning (RIC) in ischemic stroke: identification of circulating signalling factors
Supervisor
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020 - 2021 The role of carbon monoxide on modulation of microglial phagocytosis as neuroinflammatory response
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020 - 2021 The role of carbon monoxide (CO) in the balance between mitochondrial biogenesis and mitophagy
Supervisor
2017 - 2021 Carbon Monoxide – Neuroglobin axis on cytoprotection against perinatal cerebral ischemia
Supervisor of Daniela Dias Pedroso
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 - 2021 Anti-inflammatory effect of carbon monoxide on the neuron-microglia bidirectional communication
Supervisor of Nuno Ricardo Lucas Soares
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - 2020 Anti-inflammatory effect of carbon monoxide on the neuron-microglia bidirectional communication
Co-supervisor
 Mestrado em genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 - 2020 The role of ciliogenesis in carbon-monoxide induced astrocyte cytoprotection
Supervisor
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2019 Carbon monoxide against cerebral ischemia: role of mitophagy, mitochondria and cell metabolism
Supervisor of Cláudia Figueiredo Pereira
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2018 Carbon Monoxide Modulation of Astrocytic Viability Following an Ischemic Injury
Co-supervisor of Sara R. Oliveira
Universidade de Coimbra Faculdade de Medicina, Portugal
2013 - 2016/12 Carbon monoxide modulation of neuronal differentiation: novel cell therapy strategies for neurological disorders
Supervisor of Ana S. Almeida
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015 - 2016 Disclosing CO-induced cytoprotection in astrocytes: role of FosB
Supervisor of Deborah Zucolotto de Silva
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2015 Berries driven (poly)phenols-induced cytoprotection in cardiomyocytes
Supervisor of Joel Garcia Guerra
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2015 Non - cell autonomous neuroprotective effect of carbon monoxide: microglia-to-neuron communication
Co-supervisor of Nuno Ricardo Lucas Soares
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2014 Carbon monoxide: novel strategy to promote neuronal differentiation
Supervisor of Melissa Rebelo Vieira
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2013 Carbon monoxide, autophagy and cytoprotection in response to cerebral ischemia
Supervisor of Cláudia Figueiredo Pereira
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2009 - 2012/12/12 Disclosing Carbon Monoxide Protection in Cerebral Hypoxia-Ischemia: Insight in the cellular mechanisms
Supervisor of Cláudia S.F. Queiroga
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011 - 2012 Mono´xido de carbono como agente protector num modelo de hipo´xia-isque´mia e reperfusa~o atrave´s da activac¸a~o da autofagia
Supervisor
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010 - 2011 Estudo do efeito anti-apoptótico do monóxido de carbono: comunicação astrócito-neurónio por modulação da sinalização purinérgica
Supervisor of Raquel Azeitão Alves
Universidade de Lisboa Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020/01/16 - 2020/01/19 Winter retreat organization of Twining Lysocil (http://lysocil.com/) (2020/01/16 - 2020/01/19)
Meeting (Member of the Scientific Committee)
2019/04 - 2019/04 Teaming DiscoveriesCTR “Synapse function, dysfunction and repair” workshop (2019/04 - 2019/04)
Conference (Member of the Scientific Committee)
 Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2017 - 2019 Organisation of 5 Workshops on Translational Research for medical doctors in collaboration with Hospital Egas Moniz, Hospital São Francisco Xavier and Hospital D. Estefânia (2017 - 2019)
Workshop (President of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017/05/08 - 2017/05/09 Translational Workshop in Lisbon - Transautopagy COST Action (2017/05/08 - 2017/05/09)
Workshop (Member of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015/06 - 2015/06 Organization and chair of the symposium entitled “CO, Neuroprotection and Neuroinflammation” in the European Society for Neurochemistry Meeting, 14-17 June, 2015 in Tartu, Estonia (about 50 participants in the symposium and 200 participants in the meeting) (2015)
Symposium (Member of the Scientific Committee)
 Tartu Ülikool Centre of Translational Genomics, Estonia
2013/10/24 - 2013/10/25 Workshop of European Network of Gasotransmistters ENOG COST Action (2013/10/24 - 2013/10/25)
Workshop (President of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/12/13 Cell competition in Drosophila: the effect of suboptimal cells accumulation and an insight into the winner-loser communication in a competition scenario
(Thesis) Arguer
 Mariana Marques dos Reis (PhD)
2017/07/26 Evaluation Panel for PhD Thesis discussion entitled: Dissecting Lipocalin-2 as a novel modulator of brain processes
(Thesis) Main arguer
 Ana Catarina Oliveira Ferreira (PhD)
Universidade do Minho Escola de Medicina, Portugal
2017/06/28 Evaluation panel of PhD thesis discussion entitled: Nrf2 Confers Disease Tolerance to Bloodstream Infections
(Thesis) Main arguer
 Ana Martins Ribeiro (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Instituto Gulbenkian de Ciência, Portugal

Association member

Society Organization name Role
2018/11/01 - Current WIDESPREAD-05-2017: Twinning Excel in Rare Diseases’ Research: Focus on LYSOsomal Disorders and CILiopathies LYSOCYL Responsible for one WorkPackage
2016 - Current COST Action 15138 European Network of Multidisciplinary Research and Translation of Autophagy knowledge (TRANSAUTOPHAGY) Member of management Committee
2008 - Current European Society for Neurochemistry (ESN) Member
2011 - 2015 COST Action 1005 Gasotransmitters: from basic science to therapeutic applications (ENOG: European Network on Gasotransmitters) Member of management committee

Committee member

Activity description
Role 		Institution / Organization
2019 - 2019 Member of "Conselho da Faculdade"
Member
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - Current Coordination (Regente) and teaching "Physiology" at Biochemistry BSc Bioquímica (Licenciatura) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2019 Coordination (Regente) and teaching at the Advanced Course “Cell Regulation” of NOVA Biomedical Research Master NOVA Biomedical Research Master (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 - 2018 Teaching at “Tissue, Cells and Molecules” subject in the 1st year of Master in Medicine Tecido, Células e Moléculas (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 - 2018 Teaching at “Molecular Mechanisms of Disease” subject in the 5th year of Master in Medicine Molecular Mechanisms of Diseases (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2013 - 2018 Coordination (Regente) and teaching at the Advanced Course “Chronic and Degenerative Diseases” of the ProRegeM Doctoral Program Advanced Course “Chronic and Degenerative Diseases” (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2022 - 2024 Participation in the Panel for Cellular and Developmental Biology at Polish National Research Centre (NCN) for the Programme Sonata Bis, Poland
Evaluator
2017 - 2020 Review Board for PEPITA Program Grant
Evaluator
 Universidade de Coimbra, Portugal Universidade de Coimbra
2017 - 2020 Expert panel for National Science Centre, Poland (NCN) for the programs: Maestro, Sonata Bis, Sonata, Opus and Preludium
Evaluator
 Narodowe Centrum Nauki, Poland Narodowe Centrum Nauki
2018 - 2018 Review panel member for PhD fellowship evaluation
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2016 - 2016 Review panel member for research contract Investigador FCT 2016
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2013 - 2015 Scientific Evaluation at iMED/Fundação AstraZeneca Innovate Competition, Portugal
Evaluator
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal AstraZeneca Produtos Farmacêuticos Lda
2012 - 2012 Grant evaluation for Association Nationale pour la Recherche (ANR), France
Evaluator
 Association nationale de la recherche technique, France Association nationale de la recherche technique

Interview (tv / radio show)

Program Topic
2018 - 2018 90 segundos de Ciência Monóxido de carbono uma molécula neuroprotetora

Journal scientific committee

Journal title (ISSN) Publisher
2018 - Current Neurochemical Research (1573-6903) Springer-Verlag
2016 - Current Molecular Neurobiology (0893-7648) Springer-Verlag
2015 - Current Autophagy (1554-8635) Landes Bioscience
2014 - Current Redox Biology (2213-2317) Elsevier
2014 - Current Cell Death and Disease (2041-4889) Springer Nature
2014 - Current Journal of Neurochemistry (1471-4159) Wiley (Blackwell Publishing)
2011 - Current British Journal of Pharmacology (1476-5381) Wiley (Blackwell Publishing)
2011 - Current Antioxidants & Redox Signaling (1557-7716) Mary Ann Liebert
Distinctions

Award

2011 Começar em Oeiras
2011 Young Investigator Award, International Society for Neurochemistry
2001 French Citation Laureate, Institute for Scientific Information

Other distinction

2019 • 1st choice at competition for Auxiliary Professor position at Department of Chemistry, at Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 • 1st choice at competition for Auxiliar Reseacher position at CEDOC, NOVA Medical School, Universidade Nova de Lisboa
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 • 1st choice at competition for Auxiliary Professor position at Department of Life Sciences, at Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 Investigador FCT
Fundação para a Ciência e a Tecnologia, Portugal