Ana Espada de Sousa (D015-D3A2-992D)

Curriculum Vitae

Ana Espada de Sousa

Ana E Sousa is Full Professor and Investigator Coordinator at the Faculdade de Medicina da Universidade de Lisboa, where she leads the Clinical Immunology Laboratory since 2014, and Group Leader at the Instituto de Medicina Molecular João Lobo Antunes (iMM) since 2003 until 2024, and Group Leader at the Gulbenkian Institute for Molecular Medicine (GIMM) since 2024 . After completing her formal training as an Internist and a subsequent PhD in the field of HIV/AIDS immunopathogenesis, she has pursued a career as full-time researcher, leading a group dedicated to human immunodeficiencies at the iMM and posteriorly GIMM, reference institutes for science in Portugal. The main research topic is human T cell development and homeostasis. Her research group gathers clinical and basic investigators in such a way to guarantee the scientific training of MD, biomedical and computational researchers with the ultimate goal of identifying new strategies for immunological reconstitution. Between 2009 and 2012, she served as President of Portuguese Society for Immunology. Among her scientific contributions to the HIV/AIDS field, it is worth emphasizing a couple of key papers that helped establish hyper-immune activation as a main determinant of HIV disease progression (Sousa, JI2002; Grossman, NatureMed2002), and that her work represents an international reference source for the study of HIV-2 infection, a naturally-occurring model of attenuated HIV disease. Additionally, her lab integrates a reference centre that performs diagnosis, specialized follow-up and research in primary immunodeficiencies, rare diseases considered natural experiments to better understand the human immune system. The ultimate goal is that her research on T-cell development in the human thymus and lymphoid tissue preservation, particularly in the context of persistent immune activation, translates into innovative immune-based therapies.

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Identification

Personal identification

Full name: Ana Espada de Sousa

Citation names

Sousa, Ana E
Ana E Sousa
Ana Espada de Sousa

Author identifiers

Ciência ID: D015-D3A2-992D
ORCID iD: 0000-0002-4618-9799

Email addresses

asousa@medicina.ulisboa.pt (Professional)
ana.e.sousa@gimm.pt (Professional)
anaespadadesousa@gmail.com (Personal)

Telephones

Fax

217999527 (Professional)

Mobile phone

938335104 (Personal)

Telephone

217999525 (Professional)

Addresses

Gulbenkian Institute for Molecular Medicine, Faculdade de Medicina, Universidade de Lisboa. Av Prof. Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Websites

https://gimm.pt/ (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Immunology
Medical and Health Sciences - Clinical Medicine
Medical and Health Sciences - Health Sciences - Infectious Diseases
Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
Medical and Health Sciences - Clinical Medicine - Allergy
Medical and Health Sciences - Clinical Medicine - General and Internal Medicine
Medical and Health Sciences - Basic Medicine - Human Genetics

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
French	Intermediate (B1)	Advanced (C1)	Upper intermediate (B2)	Advanced (C1)

Education

	Degree	Classification
2012/10/10 Concluded	Agregation (Título de Agregado) Universidade de Lisboa Faculdade de Medicina, Portugal "N/A" (THESIS/DISSERTATION)	N/A
2000/11/20 Concluded	PhD (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal "DOIS MODELOS CLÍNICOS DE INVESTIGAÇÃO DA IMUNOPATOGÉNESE DA SIDA: A RECONSTITUIÇÃO IMUNOLÓGICA APÓS TERAPÊUTICA ANTIRETROVIRAL E A INFECÇÃO PELO HIV2 " (THESIS/DISSERTATION)	20/20
1989 - 1994 Concluded	Medicina Interna (Título de especialista) Hospital de Santa Maria, Portugal	19,8/20
1986 Concluded	MD (Licenciatura) Universidade de Lisboa Faculdade de Medicina, Portugal "N/A" (THESIS/DISSERTATION)	17,1/20

Affiliation

Science

	Category Host institution	Employer
2017/01/11 - Current	Coordinating Researcher (Research)	Faculdade de Medicina da Universidade de Lisboa, Portugal
	Faculdade de Medicina da Universidade de Lisboa, Portugal (...)
2013/09/01 - 2017/01/10	Principal Investigator (Research)	Faculdade de Medicina da Universidade de Lisboa, Portugal

2007/09/01 - 2013/08/31	Auxiliary Researcher (Research)	Faculdade de Medicina da Universidade de Lisboa, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2018/05/02 - Current	Invited Full Professor (University Teacher)	Faculdade de Medicina da Universidade de Lisboa, Portugal

2013 - 2018/05/01	Invited Associate Professor (University Teacher)	Faculdade de Medicina da Universidade de Lisboa, Portugal

2005 - 2013	Invited Assistant Professor (University Teacher)	Faculdade de Medicina da Universidade de Lisboa, Portugal

Positions / Appointments

	Category Host institution	Employer
2009/11/01 - 2012/11/26	President	Portuguese Society for Immunology, Portugal

Others

	Category Host institution	Employer
2024/10/01 - Current	Group Leader	GIMM - Gulbenkian Institute for Molecular Medicine, Portugal
	GIMM - Gulbenkian Institute for Molecular Medicine, Portugal
2014/06/16 - Current	Director of the Clinical Immunology Laboratory	Faculdade de Medicina da Universidade de Lisboa, Portugal

2007/11/21 - Current	Co-Coordinator of the Center for Primary Immunodeficiency	Centro Académico de Medicina de Lisboa, Portugal

2003/01/01 - 2024/09/30	Group Leader	Instituto de Medicina Molecular, Portugal

2016/03/14 - 2022/09/01	Coordinator of the GAPIC (Department for the promotion of scientific investigation for medical students)	Faculdade de Medicina da Universidade de Lisboa, Portugal

2009/06/01 - 2016/03/14	Member of the Directive Board of the GAPIC (Department for the promotion of scientific investigation for medical students)	Faculdade de Medicina da Universidade de Lisboa, Portugal

2009/10/01 - 2013/05/14	Member of the Directive Board, Treasurer	Sociedade de Ciências Médica de Lisboa, Portugal

2004/01/01 - 2006/09/01	Director of the Flow Cytometry Unit	Instituto de Medicina Molecular, Portugal

2004/01/01 - 2005/12/31	Management Committee of the Egas Moniz Building (site of the Instituto de Medicina Molecular)	Faculdade de Medicina da Universidade de Lisboa, Portugal

2000/10/01 - 2001/09/30	Specialist in Internal Medicine	Hospital de Santa Maria, Portugal

1996/10/01 - 2001/09/30	Honorary Lecturer - Clinical Immunology	Faculdade de Medicina da Universidade de Lisboa, Portugal

1996/01/01 - 2000/10/01	PhD Scholarship from Portuguese Science Foundation	Fundação para a Ciência e a Tecnologia, Portugal

1992/10/01 - 1996/10/01	Honorary Lecturer - Medicine 2	Faculdade de Medicina da Universidade de Lisboa, Portugal

1986/01/01 - 1995/12/31	General internship / Residency / Specialist in Internal Medicine	Hospital de Santa Maria, Portugal

Projects

Grant

	Designation	Funders
2021/10/06 - 2025/10/05	Mye-InfoBank - Converting molecular profiles of myeloid cells into biomarkers for inflammation and cancer CA20117 Researcher Instituto de Medicina Molecular, Portugal	European Union Ongoing
2021/03/29 - 2024/03/28	Targeting naïve CD4 T cells to avoid human immunodeficiency PTDC/MED-IMU/0938/2020 Principal investigator Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/10/01 - 2021/09/30	Exploring the role of microRNAs in T cell function and anti-HIV defense PTDC/BIA-CEL/29257/2017 Researcher Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/08/06 - 2021/08/05	Quantitative Studies of HIV Latency PTDC/MAT-APL/31602/2017 Researcher Universidade de Lisboa Faculdade de Medicina, Portugal Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/06/01 - 2021/05/31	Investigation of a Human Virus Tumor Gene through a Chimera Virus Mouse Infection Model PTDC/BIA-VIR/27947/2017 Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/06/01 - 2021/05/31	Harnessing Follicular Helper T Cells to Control HIV PTDC/MED-IMU/30474/2017 Principal investigator Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2016/12/01 - 2021/01/31	Accelerating progress toward the new era of precision medicine (PAC-PRECISE) PAC – PRECISE - LISBOA-01-0145-FEDER-016394 Researcher Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2017/01/01 - 2020/12/31	An Omics Network to Prevent and Control Infectious Diseases and Antimicrobial Resistance (PAC-ONEIDA) PAC - ONEIDA - LISBOA-01-0145-FEDER-016417 Researcher Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/06/30 - 2020/12/30	COVID-19 prognosis: innate immune determinants Projecto nº 803; FCT - RESEARCH4COVID 19 Researcher Instituto de Medicina Molecular, Portugal	Ongoing
2016/12 - 2020/11	Accelerating progress toward the new era of precision medicine (PAC-PRECISE) PAC PRECISE - LISBOA-01-0145-FEDER-016394	Fundação para a Ciência e a Tecnologia
2020/05/02 - 2020/07/31	COVID-19 pneumonia outcome: an immunological approach 125_596759906 Researcher Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2015 - 2018	European Network linking informatics and genomics of helper T cells (ENLIGHT-TEN) "Enlight-Ten" - MSCA-ITN-2015-ETN "Enlight-Ten" - MSCA-ITN-2015-ETN Researcher Instituto de Medicina Molecular, Portugal	European Commission Concluded
2014 - 2018	European Network of Investigators Triggering Exploratory Research on Myeloid Regulatory Cells (Mye-EUNITER) COST BM1404 Researcher Instituto de Medicina Molecular, Portugal	European Commission Concluded
2015/01/01 - 2017/12/31	Targeting Germinal Centre Dysregulation in Allergy HMSP-ICT/0034/2013 HMSP-ICT/0034/2013 Researcher Instituto de Medicina Molecular, Portugal Fundação Calouste Gulbenkian, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013 - 2016	Platform for the Development of Young Physician-Scientists 2013FCG-IMM Principal investigator Instituto de Medicina Molecular, Portugal	Fundação Calouste Gulbenkian Concluded
2013/06/01 - 2015/08/31	Bee Venom as a tool to expand the human regulatory T-cell compartment PTDC/DTP-PIC/0508/2012 Researcher Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2014/01/01 - 2014/12/31	Achieving gut integrity in HIV/AIDS through IL-22 EXPL/DTP-PIC/0854/2013 Researcher Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011 - 2014	MODULATION OF HIV REPLICATION AND LATENCY IN HUMAN CD4 T CELLS BY REGULATORY SMALL RNAS #39114 #39114 Principal investigator Instituto de Medicina Molecular, Portugal	Merck Sharp and Dohme Ltd
2010 - 2014	HIV/AIDS: contribute of naïve CD4 T cell homeostasis. PTDC/SAU-MIC/109786/2009 PTDC/SAU-MIC/109786/2009 Principal investigator Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/03/01 - 2013/12/31	Cellular and molecular requirements in human Regulatory T cell development PTDC/SAU-IMU/113541/2009 Researcher Instituto de Medicina Molecular, Portugal Fundação Calouste Gulbenkian, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009 - 2012	Lymphoid tissues in HIV-2 infected patients PIC/IC/82712/2007 PIC/IC/82712/2007 Principal investigator Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009 - 2012	Long-term impact of thymectomy performed in early infancy PIC/IC/83068/2007 PIC/IC/83068/2007 Researcher Instituto de Medicina Molecular, Portugal Hospital de Santa Cruz, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007/11/01 - 2011/04/30	HIV-2 infection and thymus PTDC/SAU-MII/66248/2006 PTDC/SAU-MII/66248/2006 Principal investigator Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008 - 2011	Cellular and Molecular Response of HIV-2 and HIV-1 infection to integration modulation IISP ID#35271 IISP ID#35271 Principal investigator Instituto de Medicina Molecular, Portugal	Merck Sharp and Dohme Ltd Concluded
2008 - 2011	Immune Reconstitution after Unrelated and Haplotype-Mismatched Stem Cell Transplantation. PTDC/SAU-MII/67662/2006 PTDC/SAU-MII/67662/2006 Researcher Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007 - 2011	Programa VIH-SIDA IMM-FCG 2007FCG-IMM Principal investigator Instituto de Medicina Molecular, Portugal	Fundação Calouste Gulbenkian Concluded
2005 - 2008	The role of IL- 7 in the regulation of CD4+ T cell populations in humans POCI/BIA-BCM/61079-2004 Researcher Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005/06/01 - 2007/12/31	T cell production in HIV immunodeficiency POCI/SAU-MMO/60333/2004 POCI/SAU-MMO/60333/2004 Principal investigator Instituto de Medicina Molecular, Portugal Fundação Calouste Gulbenkian, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005/06/01 - 2007/06/30	The role of IL-7 in the homeostatic regulation of CD4+ T lymphocyte populations in humans POCI/BIA-BCM/61079/2004 Researcher Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005 - 2007	HIV-2 specific T cells POCI/SAU-IMI/55368/2004 POCI/SAU-IMI/55368/2004 Principal investigator Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2001 - 2004	HIV-2 infection as a model for the investigation of AIDS pathogenesis. POCTI 36312/CBO2000 Researcher Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book	Ana Espada de Sousa. VIH/SIDA: Imunopatogénese e Resposta Imunológica.. Lisboa, Portugal: Permanyer. 2007. Published
Book chapter	Foxall, Russell B.; Tendeiro, Rita; Sousa, Ana E.. "Role of Dendritic Cells in HIV-2 Pathogenesis". In Encyclopedia of AIDS, edited by Editors: Douglas D. Richman, Mario Stevenson and Thomas Hope. Section Editor: Sarah Rowland-Jones., 1-10. Springer New York, 2013. 10.1007/978-1-4614-9610-6_37-1 Ana Espada de Sousa. "VIH/SIDA: Imunopatogénese e Resposta Imunológica". In Manual sobre Sida. Lisboa, Portugal: Permanyer Portugal, 2011. Ana Espada de Sousa. "VIH/SIDA: Imunopatogénese e Resposta Imunológica.". In Manual sobre SIDA. Lisboa, Portugal: Permanyer, 2007. Published Ana Espada de Sousa. "VIH/SIDA: Imunopatogénese e Resposta Imunológica.". In Manual sobre SIDA. Lisboa, Portugal: Permanyer, 2004. Ana Espada de Sousa. "Reconstituição Imune com Tratamento Antirretroviral". In Biblioteca da SIDA, 3-39. Lisboa, Portugal: Edição Permanyer, 2001. Published Ana Espada de Sousa. "Citocinas e HIV - Revisitação do Tema através da Análise a Nível Celular Individualizado.". In 2º HIV/AIDS Virtual Congress http://www.aidscongress.net/article.php?sid=43.. 2001. Published Ana Espada de Sousa. "VIH/SIDA: Imunopatogénese e Resposta Imunológica.". In Manual sobre SIDA. l, Portugal: Permanyer, 2001. Published
Journal article	Torres-Valle, Alba; Aragon, Larraitz; Silva, Susana L.; Serrano, Cristina; Marcos, Miguel; Melero, Josefa; Bonroy, Carolien; et al. "In-depth blood immune profiling of Good syndrome patients". Frontiers in Immunology 14 (2023): http://dx.doi.org/10.3389/fimmu.2023.1285088. 10.3389/fimmu.2023.1285088 Vicente, Manuel M.; Alves, Inês; Fernandes, Ângela; Dias, Ana M.; Santos-Pereira, Beatriz; Pérez-Anton, Elena; Santos, Sofia; et al. "Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity". Cellular & Molecular Immunology (2023): http://dx.doi.org/10.1038/s41423-023-01052-7. 10.1038/s41423-023-01052-7 Gomes, André M. C.; Farias, Guilherme B.; Trombetta, Amelia C.; Godinho-Santos, Ana; Parreira, Inês; Gonçalves, Hélder Diogo; Simões, Mariana Lessa; et al. "Phenotype of BTK-lacking myeloid cells during prolonged COVID-19 and upon convalescent plasma". European Journal of Haematology 110 2 (2023): 209-212. http://dx.doi.org/10.1111/ejh.13881. Published • 10.1111/ejh.13881 Cláudia Varandas; Maria Conceição Pereira-Santos; Marta Neto; Ana E. Sousa; Anabela Lopes; Susana L. Silva. "Serum IL-22 binding protein as a marker for atopic dermatitis activity and response to dupilumab treatment". Clinical & Experimental Allergy 52 6 (2022): 820-823. https://doi.org/10.1111/cea.14147. 10.1111/cea.14147 Motta-Raymundo, Adriana; Rosmaninho, Pedro; Santos, Diana F.; Ferreira, Ruben D.; Silva, Sara P.; Ferreira, Cristina; Sousa, Ana E.; Silva, Susana L.. "Contribution of Helicobacter pylori to the Inflammatory Complications of Common Variable Immunodeficiency". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.834137. 10.3389/fimmu.2022.834137 Nunes-Cabaço, Helena; Ramalho-dos-Santos, Andreia; Pires, Ana R.; Martins, Leila R.; Barata, João T.; Sousa, Ana E.. "Human CD4 T Cells From Thymus and Cord Blood Are Convertible Into CD8 T Cells by IL-4". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.834033. 10.3389/fimmu.2022.834033 Passos, Vânia; Pires, Ana R.; Foxall, Russell B.; Nunes-Cabaço, Helena; Sousa, Ana E.. "Expression of Human Endogenous Retroviruses in the Human Thymus Along T Cell Development". Frontiers in Virology 2 (2022): http://dx.doi.org/10.3389/fviro.2022.826393. 10.3389/fviro.2022.826393 Guilherme B. Farias; Robert Badura; Carolina M Conceição; André Gomes; Ana Godinho-Santos; Joel Laia; Pedro Rosmaninho; et al. "Acute HIV-1 and SARS-CoV-2 Infections Share Slan+ Monocyte Depletion—Evidence from an Hyperacute HIV-1 Case Report". Viruses (2021): https://www.mdpi.com/1999-4915/13/9/1805. 10.3390/v13091805 Aguiar de Sousa, Diana; Pereira-Santos, Maria Conceição; Serra-Caetano, Ana; Neto, Lia Lucas; Sousa, Ana Luísa; Gabriel, Denis; Correia, Manuel; et al. "Matrix Metalloproteinase-9 Levels are Associated with Brain Lesion and Persistent Venous Occlusion in Patients with Cerebral Venous Thrombosis". Thrombosis and Haemostasis 121 11 (2021): 1476-1482. http://dx.doi.org/10.1055/s-0041-1726094. 10.1055/s-0041-1726094 del Pino-Molina, Lucía; López-Granados, Eduardo; Lecrevisse, Quentin; Torres Canizales, Juan; Pérez-Andrés, Martín; Blanco, Elena; Wentink, Marjolein; et al. "Dissection of the Pre-Germinal Center B-Cell Maturation Pathway in Common Variable Immunodeficiency Based on Standardized Flow Cytometric EuroFlow Tools". Frontiers in Immunology 11 (2021): http://dx.doi.org/10.3389/fimmu.2020.603972. 10.3389/fimmu.2020.603972 Ferreira JA; Neves M; Alpalhão M; Pereira P; Cunha D; Ferreira F; Santus R; Sousa AE; Filipe PL. "EDU (5-Ethynyl-2'-Deoxyuridine)-Coupled Fluorescence-Intensity Analysis: Determining Absolute Parameters of the Cell Cycle.". Methods in molecular biology (Clifton, N.J.) (2021): http://europepmc.org/abstract/med/34085222. 10.1007/978-1-0716-1538-6_12 Giardino, G.; Sharapova, S.O.; Ciznar, P.; Dhalla, F.; Maragliano, L.; Radha Rama Devi, A.; Islamoglu, C.; et al. "Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations". Journal of Clinical Immunology (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85100001252&partnerID=MN8TOARS. 10.1007/s10875-021-00967-y Aguiar de Sousa, D.; Pereira-Santos, M.C.; Serra-Caetano, A.; Lucas Neto, L.; Sousa, A.L.; Gabriel, D.; Correia, M.; et al. "Blood biomarkers associated with inflammation predict poor prognosis in cerebral venous thrombosis:: a multicenter prospective observational study". European Journal of Neurology 28 1 (2021): 202-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-85092163063&partnerID=MN8TOARS. 10.1111/ene.14526 Lhermitte, Ludovic; Barreau, Sylvain; Morf, Daniela; Fernandez, Paula; Grigore, Georgiana; Barrena, Susana; de Bie, Maaike; et al. "Automated identification of leukocyte subsets improves standardization of database-guided expert-supervised diagnostic orientation in acute leukemia: a EuroFlow study". Modern Pathology 34 1 (2020): 59-69. http://dx.doi.org/10.1038/s41379-020-00677-7. 10.1038/s41379-020-00677-7 Cassetta, Luca; Bruderek, Kirsten; Skrzeczynska-Moncznik, Joanna; Osiecka, Oktawia; Hu, Xiaoying; Rundgren, Ida Marie; Lin, Ang; et al. "Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation". Journal for ImmunoTherapy of Cancer 8 2 (2020): e001223. http://dx.doi.org/10.1136/jitc-2020-001223. 10.1136/jitc-2020-001223 Gullo, Irene; Costa, Catarina; Silva, Susana L; Ferreira, Cristina; Motta, Adriana; Silva, Sara P; Ferreira, Rúben Duarte; et al. "The Dysfunctional Immune System in Common Variable Immunodeficiency Increases the Susceptibility to Gastric Cancer". Cells 9 6 (2020): 1498. http://dx.doi.org/10.3390/cells9061498. 10.3390/cells9061498 Grossman, Zvi; Singh, Nevil J.; Simonetti, Francesco R.; Lederman, Michael M.; Douek, Daniel C.; Deeks, Steven G.; And 8 contibuting authors with full authorship. "‘Rinse and Replace’: Boosting T Cell Turnover To Reduce HIV-1 Reservoirs". Trends in Immunology (2020): http://dx.doi.org/10.1016/j.it.2020.04.003. 10.1016/j.it.2020.04.003 Godinho-Santos, A.; Foxall, R.B.; Antão, A.V.; Tavares, B.; Ferreira, T.; Serra-Caetano, A.; Matoso, P.; Sousa, A.E.. "Follicular Helper T Cells Are Major Human Immunodeficiency Virus-2 Reservoirs and Support Productive Infection". The Journal of infectious diseases 221 1 (2020): 122-126. http://www.scopus.com/inward/record.url?eid=2-s2.0-85076502884&partnerID=MN8TOARS. 10.1093/infdis/jiz431 Badura, R.; Foxall, R.B.; Ligeiro, D.; Rocha, M.; Godinho-Santos, A.; Trombetta, A.C.; Sousa, A.E.. "Early ART in Acute HIV-1 Infection: Impact on the B-Cell Compartment". Frontiers in Cellular and Infection Microbiology 10 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85088815505&partnerID=MN8TOARS. 10.3389/fcimb.2020.00347 M. C. P. Santos; A. Serra-Caetano; E. Pedro; A. Melo; I. Caramalho; M. P. Barbosa; R. M. M. Victorino; A. E. Sousa. "Expansion of FOXP3+ regulatory CD4 T cells upon exposure to hymenoptera venom during the beekeeping season". Allergy (2019): https://doi.org/10.1111/all.13713. 10.1111/all.13713 Ana E Sousa. "EuroFlow-Based Flowcytometric Diagnostic Screening and Classification of Primary Immunodeficiencies of the Lymphoid System". Frontiers in Immunology (2019): http://dx.doi.org/10.3389/fimmu.2019.01271. 10.3389/fimmu.2019.01271 van der Burg M; Kalina T; Perez-Andres M; Vlkova M; Lopez-Granados E; Blanco E; Bonroy C; et al. "The EuroFlow PID Orientation Tube for Flow Cytometric Diagnostic Screening of Primary Immunodeficiencies of the Lymphoid System.". Frontiers in immunology (2019): http://europepmc.org/abstract/med/30886612. 10.3389/fimmu.2019.00246 Blanco, E.; Pérez-Andrés, M.; Arriba-Méndez, S.; Serrano, C.; Criado, I.; Del Pino-Molina, L.; Silva, S.; et al. "Defects in memory B-cell and plasma cell subsets expressing different immunoglobulin-subclasses in patients with CVID and immunoglobulin subclass deficiencies". Journal of Allergy and Clinical Immunology (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85063670071&partnerID=MN8TOARS. 10.1016/j.jaci.2019.02.017 Silva, S.L.; Fonseca, M.; Pereira, M.L.M.; Silva, S.P.; Barbosa, R.R.; Serra-Caetano, A.; Blanco, E.; et al. "Monozygotic Twins Concordant for Common Variable Immunodeficiency: Strikingly Similar Clinical and Immune Profile Associated With a Polygenic Burden". Frontiers in Immunology 10 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85076341519&partnerID=MN8TOARS. 10.3389/fimmu.2019.02503 Dorhoi A; Glaría E; Garcia-Tellez T; Nieuwenhuizen NE; Zelinskyy G; Favier B; Singh A; et al. "MDSCs in infectious diseases: regulation, roles, and readjustment.". Cancer immunology, immunotherapy : CII (2018): http://europepmc.org/abstract/med/30569204. 10.1007/s00262-018-2277-y Blanco E; Pérez-Andrés M; Arriba-Méndez S; Contreras-Sanfeliciano T; Criado I; Pelak O; Serra-Caetano A; et al. "Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood.". The Journal of allergy and clinical immunology (2018): http://europepmc.org/abstract/med/29505809. 10.1016/j.jaci.2018.02.017 Valter R. Fonseca; Ana Agua-Doce; Ana Raquel Maceiras; Wim Pierson; Filipa Ribeiro; Vasco C. Romão; Ana Rita Pires; et al. "Human blood T fr cells are indicators of ongoing humoral activity not fully licensed with suppressive function". Science Immunology 2 14 (2017): eaan1487-eaan1487. https://doi.org/10.1126%2Fsciimmunol.aan1487. 10.1126/sciimmunol.aan1487 Fernandes SM; Pires AR; Matoso P; Ferreira C; Nunes-Cabaço H; Correia L; Valadas E; et al. "HIV-2 infection is associated with preserved GALT homeostasis and epithelial integrity despite ongoing mucosal viral replication.". (2017): http://europepmc.org/abstract/med/28513595. 10.1038/mi.2017.44 Pereira PD; Serra-Caetano A; Cabrita M; Bekman E; Braga J; Rino J; Santus R; et al. 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Journal of Virology 80 24 (2006): 12425-12429. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845410584&partnerID=MN8TOARS. 10.1128/JVI.01557-06 Maria, V.; Albuquerque, A.; Loureiro, A.; Sousa, A.; Victorino, R.. "Lesson of the week: Severe cholestatic hepatitis induced by pyritinol". British Medical Journal 328 7439 (2004): 572-574. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642288622&partnerID=MN8TOARS. Sousa, A.E.; Carneiro, J.; Meier-Schellersheim, M.; Grossman, Z.; Victorino, R.M.M.; Sousa AE; Carneiro J; et al. "CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load". Journal of Immunology 169 6 (2002): 3400-3406. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037105617&partnerID=MN8TOARS. 10.4049/jimmunol.169.6.3400 João, M.; Silva, N.; Lucas, M.; Sousa, A.; Corujo, C.; Alves do Carmo, J.; Victorino, R.M.M.. "Long lasting myelodysplastic syndrome complicated by autoimmune hemolytic anemia and non-Hodgkin's lymphoma [2]". European Journal of Haematology 68 2 (2002): 122-124. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036251242&partnerID=MN8TOARS. 10.1034/j.1600-0609.2002.00557.x Grossman, Z.; Meier-Schellersheim, M.; Sousa, A.E.; Victorino, R.M.M.; Paul, W.E.. "CD4⁺ T-cell depletion in HIV infection: Are we closer to understanding the cause?". Nature Medicine 8 4 (2002): 319-323. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036103096&partnerID=MN8TOARS. 10.1038/nm0402-319 Sousa, A.E.; Chaves, A.F.; Loureiro, A.; Victorino, R.M.M.. "Comparison of the frequency of interleukin (IL)-2-, interferon-¿-, and IL-4-producing T cells in 2 diseases, human immunodeficiency virus types 1 and 2, with distinct clinical outcomes". Journal of Infectious Diseases 184 5 (2001): 552-559. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035450638&partnerID=MN8TOARS. 10.1086/322804 Sousa, A.E.; Chaves, A.F.; Doroana, M.; Antunes, F.; Victorino, R.M.M.. "Bulk cytokine production versus frequency of cytokine-producing cells in HIV1 infection before and during HAART". Clinical Immunology 97 2 (2000): 162-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033778273&partnerID=MN8TOARS. 10.1006/clim.2000.4930 Nunes da Silva MJ; Oliveira V; Sousa AE; Lucas M; Victorino RM. "[Headaches, otalgia and peripheral facial palsy as a form of presentation of neurosyphilis]". (2000): http://europepmc.org/abstract/med/11055060. Cavaleiro, R.; Sousa, A.E.; Loureiro, A.; Victorino, R.M.M.. "Marked immunosuppressive effects of the HIV-2 envelope protein in spite of the lower HIV-2 pathogenicity". AIDS 14 17 (2000): 2679-2686. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034492881&partnerID=MN8TOARS. 10.1097/00002030-200012010-00007 Sousa AE; Chaves AF; Doroana M; Antunes F; Victorino RM; Sousa, A.E.; Chaves, A.F.; et al. "Kinetics of the changes of lymphocyte subsets defined by cytokine production at single cell level during highly active antiretroviral therapy for HIV-1 infection.". Journal of immunology (Baltimore, Md. : 1950) 162 6 (1999): 3718-3726. http://europepmc.org/abstract/med/10092835. Sousa, A.E.; Chaves, A.F.; Doroana, M.; Antunes, F.; Victorino, R.M.M.. "Early reduction of the over-expression of CD40L, OX40 and Fas on T cells in HIV-1 infection during triple anti-retroviral therapy: Possible implications for lymphocyte traffic and functional recovery". Clinical and Experimental Immunology 116 2 (1999): 307-315. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032894849&partnerID=MN8TOARS. 10.1046/j.1365-2249.1999.00872.x Lucas, M.; Rebocho, L.; Sousa, A.E.; Palhano, M.J.; Victorino, R.M.M.. "Adenocarcinoma of the lung in HIV2 infection". European Journal of Internal Medicine 9 1 (1998): 49-52. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031812555&partnerID=MN8TOARS. Sousa, A.E.; Victorino, R.M.M.. "Single-cell analysis of lymphokine imbalance in asymptomatic HIV-1 infection: Evidence for a major alteration within the cd8⁺ T cell subset". Clinical and Experimental Immunology 112 2 (1998): 294-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031751013&partnerID=MN8TOARS. 10.1046/j.1365-2249.1998.00585.x Sousa AE; Ventura F; Silva AC; Baptista A; Victorino RM; de Moura MC; Sousa, A.E.; et al. "Centrocytic lymphoma presenting as a subphrenic abscess and a solitary liver nodule.". Hepato-gastroenterology 44 15 (1997): 664-666. http://europepmc.org/abstract/med/9222667. Sousa, A.E.; Lucas, M.; Mayer da Silva, J.; Victorino, R.M.M.. "HIV2 infection and porphyria cutanea tarda". European Journal of Internal Medicine 7 1 (1996): 65-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029955703&partnerID=MN8TOARS. Maria VA; Pimpão MV; Carvalho ML; Sousa AE; Lucas MM; Victorino RM. "[The use of serological tests for detecting HIV infection in general clinical consultations and hospital consultations]". Acta medica portuguesa (1995): http://europepmc.org/abstract/med/8533615. Victorino RM; Sousa AE; Ruprecht, RuthM.; Baba, TimothyW.; Greene, MichaelF.; Almond, N.; Cranage, M.; et al. "Attenuated vaccines for AIDS.". Lancet (London, England) 346 8968 (1995): 177-179. http://europepmc.org/abstract/med/7603240. 10.1016/s0140-6736(95)91235-5 Sousa AE; Lucas M; Palhano MJ; de Deus J; Damião J; Victorino RM. "[Cytomegalovirus-induced colitis in HIV infection. Considerations on its diagnosis, treatment and complications]". Acta medica portuguesa (1995): http://europepmc.org/abstract/med/7625221. Sousa, A.E.; Lucas, M.; Palhano, M.J.; de Deus, J.; Damião, J.; Victorino, R.M.. "Cytomegalovirus-induced colitis in HIV infection. Considerations on its diagnosis, treatment and complications,Colite pelo citomegalovirus na infecção pelo VIH. Considerações sobre o diagnóstico, terapêutica e complicações.". Acta medica portuguesa 8 4 (1995): 247-251. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029284373&partnerID=MN8TOARS. Maria, V.A.; Pimpão, M.V.; Carvalho, M.L.; Sousa, A.E.; Lucas, M.M.; Victorino, R.M.. "The use of serological tests for detecting HIV infection in general clinical consultations and hospital consultations,Utilização de testes serológicos para detecção de infecção pelo VIH em consultas de clínica geral e em consultas hospitalares.". Acta médica portuguesa 8 10 (1995): 543-552. http://www.scopus.com/inward/record.url?eid=2-s2.0-18344409680&partnerID=MN8TOARS. Sousa, A.E.; Lucas, M.; Victorino, R.M.; De Moura, M.C.. "Liver cirrhosis associated with severe haemolytic anaemia interstitial lung disease and autoimmune thyroiditis". European Journal of Gastroenterology and Hepatology 6 11 (1994): 1067-1069. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027997901&partnerID=MN8TOARS. Sousa, A.E.; Lucas, M.; Esperanca, P.; Victorino, R.M.M.. "Asymmetric paraparesis and hematologic autoimmune phenomena in HIV2 infection". European Journal of Internal Medicine 4 4 (1993): 333-335. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027882524&partnerID=MN8TOARS. Sousa, A.E.; Lucas, M.; Tavoral, I.; Victorino, R.M.M.. "Takayasu's disease presenting as a nephrotic syndrome due to amyloidosis". Postgraduate Medical Journal 69 812 (1993): 488-489. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027252603&partnerID=MN8TOARS. 10.1136/pgmj.69.812.488
Preprint	Stuchly, Jan; Novak, David; Brdickova, Nadezda; Hadlova, Petra; Iksi, Ahmad; Kuzilkova, Daniela; Svaton, Michael; et al. "Deconstructing Complexity: A Computational Topology Approach to Trajectory Inference in the Human Thymus withtviblindi". 2023. http://dx.doi.org/10.1101/2023.07.13.547329. 10.1101/2023.07.13.547329 Raposo, Alexandre A. S. F.; Rosmaninho, Pedro; Silva, Susana L.; Paço, Susana; Brazão, Maria E.; Godinho-Santos, Ana; Tokunaga, Yumie; et al. "Decoding mutational hotspots in human disease through the gene modules governing thymic regulatory T cells". 2023. http://dx.doi.org/10.1101/2023.12.27.573411. 10.1101/2023.12.27.573411 Manuel M Vicente; Inês Alves; Ângela Fernandes; Ana M Dias; Elena Pérez-Anton; Alexandra Correia; Afonso R M Almeida; et al. "N-glycans mannosylation controls T-cell development by reprogramming thymocyte commitment, fate and repertoire". 2022. https://doi.org/10.1101/2022.02.04.22270265. 10.1101/2022.02.04.22270265
Thesis / Dissertation	Ana Espada de Sousa. "Two clinical models in the investigation of AIDS pathogenesis: The post-HAART immune reconstitution and the HIV2 infection.". PhD, Faculdade de Medicina da Universidade de Lisboa, 2000.

Intellectual property

Provisional application for patent

2023. "Genomic Mutations".
Protected

Activities

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2017 - Current	Gene therapy for HIV cure using RNA replicons Co-supervisor	Microbiology (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - Current	Bioengineered approaches for the manufacture of an artificial human thymus mimicking device Co-supervisor	Bioengineering MIT Portugal Program, Portugal
2021/03/01 - 2025/02/28	Deciphering complex inborn errors of immunity through the integration of clinical data, high-dimensional immune profile and whole-genome sequencing Co-supervisor of Adriana Motta Raymundo	CAML PhD (PhD) Instituto de Medicina Molecular, Portugal
2020/09/01 - 2024/08/31	Revealing lung repair after ARDS through the IL-22 path Co-supervisor of André Miguel Carapinha Gomes	CAML PhD (PhD) Instituto de Medicina Molecular, Portugal
2017 - 2018	Human regulatory vs conventional T cells: a transcriptomic analysis Co-supervisor	Biologia Molecular e Celular (Master) Universidade de Coimbra, Portugal
2012 - 2016	Living without thymus: lessons from adults thymectomized in early infancy. Supervisor	Clinical Immunology (PhD) Faculdade de Medicina da Universidade de Lisboa, Portugal
2011 - 2015	HIV Infection and Gut-Associated Lymphoid Tissue. Supervisor	Clinical Immunology (PhD) Faculdade de Medicina da Universidade de Lisboa, Portugal
2008 - 2012	B cells at the crossroad of immune responses: insights from primary B-cell immunodeficiencies Supervisor	Immunology (PhD) Faculdade de Medicina da Universidade de Lisboa, Portugal
2007 - 2012	HIV-2 immunopathology: how the immune system deals with long-lasting infection. Supervisor	Immunology (PhD) Faculdade de Medicina da Universidade de Lisboa, Portugal
2006 - 2011	Papel da carga viral celular na imunodeficiência HIV/SIDA: contributo do estudo da infecção pelo HIV-2. Supervisor	Immunology (PhD) Faculdade de Medicina da Universidade de Lisboa, Portugal
2006 - 2010	Development of regulatory T cells in the human thymus: one step beyond. Supervisor	Immunology (PhD) Faculdade de Medicina da Universidade de Lisboa, Portugal
2006 - 2010	Strategies for T-cell reconstitution: insights from human clinical models. Supervisor	Immunology (PhD) Faculdade de Medicina da Universidade de Lisboa, Portugal
2005 - 2009	HIV-specific responses, T-cell activation and regulatory T-cells in AIDS pathogenesis: lessons from the HIV-2 model. Supervisor	Immunology (PhD) Faculdade de Medicina da Universidade de Lisboa, Portugal
2005 - 2009	Modulação de Células Dendríticas e Monócitos pelo Vírus da Imunodeficiência Humana Tipo 2. Supervisor	Immunolgy (PhD) Faculdade de Medicina da Universidade de Lisboa, Portugal
2004 - 2009	Title: Studies on a human model and a murine model of immunodeficiency: HIV-2 infection and TACI deficiency. Supervisor	Immunology (PhD) Faculdade de Medicina da Universidade de Lisboa, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2019/06/11 - 2019/06/12	HIV Pathogenesis: Lessons from HIV-2. ANRS AC41 International Workshop, Paris, France, June 11-12, 2019. (2019/06/11 - 2019/06/12) Conference (Member of the Organising Committee)	Agence Nationale de Recherches sur le SIDA et les Hépatites Virales, France
2019 - 2019	26th International HIV Dynamics & Evolution, Cascais, Portugal, March 24-27, 2019. (2019/03/24 - 2019/03/27) Conference (Member of the Organising Committee)	UC San Diego School of Medicine Continuing Medical Education, United States

Association member

	Society Organization name	Role
2018 - Current	EFIS-Immunology Letters (IL) Study Group titled “T_CELL_CONNECT_EUROPE”, European Federation of Immunology Societies (EFIS). https://www.efis.org/efis-support/efis-il-study-groups/index.html	member
2015 - Current	Euroflow Consortium https://euroflow.org/	Member and currently part of the Euroflow Board
2014 - Current	International AIDS Society (IAS)	member
2006 - Current	European Society for Immunodeficiency (ESID)	Member
1996 - Current	The American Association of Immunologists (AAI)	member
1990 - Current	Portuguese Society for Immunology	Member and Presidente from 2009-12
1990 - Current	Sociedade de Ciências Médica de Lisboa, Portugal	Member and Member of the Directive Board, Treasurer 2009-2013
1990 - Current	Sociedade Portuguesa de Medicina Interna	member

Committee member

	Activity description Role	Institution / Organization
2018 - Current	Member of the Conselho Consultivo do GAT - Grupo de Ativistas em Tratamentos (www.gatportugal.org), a NGO with main participation of people living with HIV. Advisor / Consultant	Grupo de Ativistas em Tratamentos, Portugal
2016 - Current	Member of the "Comissão de Avaliação de Tecnologias de Saúde (CATS)" INFARMED, Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal Member	Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
2015 - Current	Member of the Biosciences Scientific Board Santa Casa da Misericórdia de Lisboa, Portugal Member	Santa Casa da Misericórdia de Lisboa, Portugal
2014 - Current	Member of the Board of the LisbonBioMed - FCT PhD Program Instituto de Medicina Molecular, Portugal Member	Instituto de Medicina Molecular, Portugal
2010 - Current	Member of the Scientific Board of the Lisbon Medical Academic Center (AMC) Doctoral Programme Member	Faculdade de Medicina da Universidade de Lisboa, Portugal
2009 - Current	Member of the Scientific Council (Management of the Scientific Area of the Medical School) Faculdade de Medicina da Universidade de Lisboa, Portugal Member	Faculdade de Medicina da Universidade de Lisboa, Portugal
2017/07/01 - 2024/07/31	Member of the Exceutive Board of the National Ethics Committee for Clinical Research, Portugal Member	National Ethics Committee for Clinical Research, Portugal
2014/07/02 - 2024/07/31	Member of the National Ethics Committee for Clinical Research, Portugal Member	National Ethics Committee for Clinical Research, Portugal
2012 - 2014	Board of Education & Advanced Training Coordinator	Instituto de Medicina Molecular, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2018 - Current	Master-course Clinical Microbiology and Emerging Infectious Diseases	Clinical Immunology (Mestrado)	Faculdade de Medicina da Universidade de Lisboa, Portugal
2015 - Current	Clinical Immunology / Medicina 2 - 5th year of the Medical Course - Faculdade de Medicina da Universidade de Lisboa	Estudos Básicos de Medicina	Faculdade de Medicina da Universidade de Lisboa, Portugal
2014 - Current	Immunology course for the PhD program LisbonBioMed and PhD program of the Lisbon Academic Medical Course	Immunology (Curso de doutoramento (conclusão de unidades curriculares))	Faculdade de Medicina da Universidade de Lisboa, Portugal Instituto de Medicina Molecular, Portugal
1996 - Current	Clinical Immunology - optative discipline of the Medical Course - Faculdade de Medicina da Universidade de Lisboa	Clinical Immunology (Mestrado integrado)	Faculdade de Medicina da Universidade de Lisboa, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2018 - Current	Member of the referee panel for evaluation of research projects in Medicine, Health Sciences and Biology Research Council of Norway (RCN), Norway Evaluator	Research Council of Norway (RCN), Norway	Research Council of Norway (RCN)
2010 - Current	Peer-Review of Grants/ Positions, namely for FCT, Welcome Trust UK, NIH, Multiple Sclerosis Research Australia, British HIV Association, Israel Science Foundation Evaluator
2005 - Current	Peer-Review Activity for several journals including: Journal of Clinical Investigation; Blood; Journal of Immunology; Clinical Immunology; Clinical and Experimental Immunology; Retrovirology; Viral Immunology; AIDS; JAIDS; AIDS Research and Human Retrovirology; Expert Review of Anti-infective Therapy; Clinical and Experimental Allergy; Journal of Immunology Methods; Journal of Infectious Diseases Evaluator
2014 - 2017	Coordinator of the FCT Board of Evaluators of the Final Project Reports of the area of Diagnosis, Therapeuthic and Public Health. Evaluator	Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia
2015 - 2015	Member of the evaluation committee of the research unit Centre International de recherche en infectiologie (CIRI), at Lyon – CIRI to be coordinated by HCERES – Haute conseil de l’evaluation de la recherche et de l’enseignement supérieur Evaluator	HCERES – Haute conseil de l’evaluation de la recherche et de l’enseignement supérieur, France	HCERES – Haute conseil de l’evaluation de la recherche et de l’enseignement supérieur
2007 - 2012	Member of the FCT board of evaluation of PhD and Post-Doc scholarship applications Evaluator	Fundação para a Ciência e a Tecnologia, Portugal

Mentoring / Tutoring

	Topic	Student name
2014 - Current	Master thesis of medical students	Several medical students
2010 - Current	Research initiation for medical students through annual projects funded by GAPIC	Several MD Students
2004 - Current	Laboratory and research training, as part as of the residency in the medical speciality of Immunolallergology,	Several MDs form different hospitals
2002 - Current	Post- doctoral and career development	Several PhDs
1996 - Current	Training in Clinical Immunology of physicians during their general internship training or residency in Internal Medicine	Several MDs

Distinctions

Award

2019	Prémio de Investigação em Autoimunidade NEDAI 2018 Sociedade Portuguesa de Medicina Interna, Portugal
2015	Prémio NEDAI de Investigação Básica em Autoimunidade Sociedade Portuguesa de Medicina Interna, Portugal
2012	Prémio NEDAI de Investigação Básica em AutoImunidade 2012 Sociedade Portuguesa de Medicina Interna, Portugal
2008	Prémio Pfizer de Investigação Clínica Sociedade de Ciências Médica de Lisboa, Portugal
2005	Prémio de Investigação Bristol-Myers Squibb em Infecção por Virus da Imunodeficiência Humana Associação Portuguesa para o Estudo Clínico da SIDA (APECS), Portugal
2004	AMI – Saúde / Doenças Infecciosas e Parasitárias – Menção Honrosa AMI - Associação Médica Internacional, Portugal
2004	Estudos VIH - Glaxo-Smith Kline Sociedade Portuguesa de Medicina Interna, Portugal
2003	Prémio LabMed Saúde - 1ª Menção Honrosa Laboratório LabMed, Portugal
2002	Prémio Dr. José Luís Champalimaud - Investigação aplicada Direcção-Geral da Saúde, Portugal
2002	Prémio Dr. José Luís Champalimaud - Investigação Básica (Menção Honrosa). Direcção-Geral da Saúde, Portugal
1998	Prémio Pfizer (Menção Honrosa) Sociedade de Ciências Médica de Lisboa, Portugal

Other distinction

2005	Projecto de Investigação Astra-Zeneca Fundação Astra-Zeneca, Portugal