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Filomena Silva completed her Biochemistry Degree "Licenciatura" from the University of Beira Interior (UBI), in 2006. In 2014 Filomena completed her PhD in Health Sciences and Technologies, specialty in Biochemistry from the Faculty of Pharmacy, Universidade de Coimbra. During her PhD, Filomena Silva centralized her activity in Toxicology and Clinical Biochemistry fields, with emphasis on the characterization of pharmacological and toxicological mechanisms of action of anti-inflammatory and cytostatic molecules. Filomena was dedicated to the study of new therapeutic associations with potential application for treatment of skin inflammatory diseases or for the chemoprevention of cancer, in order to increase the clinical efficiency and to reduce side effects of these molecules, individually. In her first post-doctoral period (2014-2015) in Centre of Agronomic and Agro-Industrial Biotechnology of Alentejo (CEBAL, Portugal) Filomena was focused on the study of biological activity of natural compounds on different cancer cell models. From 2015 until now, FS is part of the Mitochondrial Toxicology and Experimental Therapeutics (MitoXT) group at Center for Neuroscience and Cell Biology (CNC). In her first year in this group (2015-2016), FS investigated the modulation of mitochondrial oxidative stress by targeted antioxidant compounds. From 2017 until now, her interests include the role of mitochondrial dysfunctions and oxidative stress mechanisms in the progression of SOD1-fALS. During this time, FS has been dedicated to study differences in metabolic phenotype between lymphoblasts from ALS patients with and without SOD1 mutations, to discern mutant-SOD1 effects on mitochondrial function. Since May 2018, FS is a principal investigator of the project entitled: “Mito4ALS - Development of Novel Mitochondria-Targeted Antioxidants for Improving SOD1-Familial Amyotrophic Lateral Sclerosis Phenotype” funded by Portuguese Foundation for Science and Technology.
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Identification

Personal identification

Full name
Filomena José Pereira da Silva Grilo da Silva

Citation names

  • Silva, Filomena S.G.

Author identifiers

Ciência ID
D112-1890-AD44
ORCID iD
0000-0001-7143-8905
Researcher Id
J-8041-2016

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Toxicology
  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2017/05/01 - 2019/08/11
Concluded
 Development of Novel Mitochondria-Targeted Antioxidants for Improving SOD1-Familial Amyotrophic Lateral Sclerosis Phenotype (Pós-doutoramento)
Fundação para a Ciência e a Tecnologia, Portugal
2019/01 - 2019/04
Concluded
 Postgraduate Course on Animal Experimentation (Pós-Graduação)
Major in Researcher/Coordinator accreditation - FELASA C category, DGAV, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Approved
2015/12/01 - 2016/07/31
Concluded
 Modulation of mitochondrial oxidative stress by targeted antioxidant compounds (Pós-doutoramento)
Centro de Neurociências e Biologia Celular, Portugal
2014/06/01 - 2015/09/30
Concluded
 Study of the biological activity of Eucalyptus spp. Bark Extracts rich in triterpenic acids on different cancer cell models (Pós-doutoramento)
Centro de Biotecnologia Agrícola e Agro-Alimentar do Alentejo, Portugal
2007/10/01 - 2014/02/21
Concluded
 PhD in Health Sciences and Technologies, specialty in Biochemistry (Doutoramento)
Universidade de Coimbra, Portugal
"“Acitretin and isotretinoin: mitochondrial, cellular and cytogenotoxic studies. Combined action with antiestrogens, NBUVB or PUVA”" (THESIS/DISSERTATION)
 Praise and Distinction
2008 - 2008
Concluded
 Postgraduate course in Biomedical Data Analysis with SPSS support program (Pós-Graduação)
Universidade Nova de Lisboa, Portugal
 19/20
2001 - 2006
Concluded
 Graduation in Biochemistry (Licenciatura)
Universidade da Beira Interior, Portugal
""Separation of plasmid DNA isoforms by pseudo-affinity chromatography with ligands L-histidine"" (THESIS/DISSERTATION)
 17/20
Affiliation

Science

Category
Host institution 		Employer
2019/08/12 - 2021/04/30 Contracted Researcher (Research) CNC.IBILI, Portugal
2017/05/01 - 2019/08/11 Postdoc (Research) CNC.IBILI, Portugal
2015/12/01 - 2016/07/31 Postdoc (Research) CNC.IBILI, Portugal
2014/06/01 - 2015/09/30 Postdoc (Research) Centro de Biotecnologia Agrícola e Agro-Alimentar do Alentejo, Portugal
Projects

Grant

Designation Funders
2018/05/01 - 2021/04/30 Development of Novel Mitochondria-Targeted Agents for Improving SOD1-Familial Amyotrophic Lateral Sclerosis Phenotype
PTDC/MED-FAR/29391/2017
Principal investigator
CNC.IBILI, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017/05/05 - 2019/08/11 Postdoctoral fellowship
SFRH/BPD/122648/2016
Post-doc Fellow
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia, I.P
Ongoing
2014/06 - 2015/09 NEucBark – New valorization strategies for Eucalyptus spp. Bark Extracts (PTDC/AGR-FOR/3187/2012)
GRANT_NUMBER: PTDC/AGR-FOR/3187/2012
 Fundação para a Ciência e a Tecnologia
2007/10/01 - 2011/09/30 Acitretin and isotretinoin: mitochondrial, cellular and cytogenotoxic studies. Combined action with antiestrogens, NBUVB or PUVA
SFRH/BD/37684/2007
PhD Student Fellow
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Silva, Filomena S. G.; Costa, Cláudio F.; Marques, Ricardo J.; Oliveira, Paulo J.; Pereira, Gonçalo C.. "Pharmacological Targeting of the Mitochondrial Permeability Transition Pore for Cardioprotection". In Mitochondrial Biology and Experimental Therapeutics, edited by Oliveira, Paulo J., 423-490. NewYork: Springer International Publishing, 2018.
    Published • 10.1007/978-3-319-73344-9_20
  2. Silva, F; Guerra, A; Duarte, M; Soares, B; Freire, S; Silvestre, A; Calçada, C; Pereira-Wilson, C; Lima, C. "New valorization strategies for Eucalyptus spp: bark extracts". In WASTES 2015 – Solutions, Treatments and Opportunities, 311-316. London: Taylor & Francis Group, 2015.
    Published • 10.1201/b18853-52
Conference poster
  1. Silva, Filomena S.G.; Cunha-Oliveira, Teresa (7F1D-6E9A-C5EA); Débora, Mena; Sardão, Vilma; Duarte, Ana I.; Oliveira, Paulo J (E41F-4FB7-5948). "Unraveling glycolic pathways on amyotrophic lateral sclerosis patients presenting mutant SOD1 or unknown mutations.". Paper presented in AD/PD 2021: 15th International Conference on Alzheimer‘s & Parkinson‘s Diseases, 2021.
  2. Silva, Filomena S.G.; Cunha-Oliveira, Teresa (7F1D-6E9A-C5EA); Silva, Daniela F.; Segura, Luís; Rosenstock, Tatiana; Oliveira, Paulo J (E41F-4FB7-5948). "Oxidant/antioxidant imbalance in lymphoblasts from amyotrophic lateral sclerosis patients with SOD1 mutations and unknown mutations.". Paper presented in 11th Targeting Mitochondria 2020 Workshop & Congress, Virtual Meeting, 2020.
  3. Cunha-Oliveira, Teresa (7F1D-6E9A-C5EA); Oliveira, Paulo J (E41F-4FB7-5948); Silva, Filomena S.G.. "Exploratory analysis of mitochondrial metabolism in lymphoblasts from Amyotrophic Lateral Sclerosis patients to reveal discriminant biomarkers.". Paper presented in 54th Annual Meeting of the European Society for Clinical Investigation, Virtual Event., 2020.
  4. Silva, Filomena S.G.; Cunha-Oliveira, Teresa (7F1D-6E9A-C5EA); Oliveira, Paulo J (E41F-4FB7-5948). "Glycolytic fluxes and metabolic profiles distinguish amyotrophic lateral sclerosis patients from healthy controls.". Paper presented in 54th Annual Meeting of the European Society for Clinical Investigation, Virtual Event., 2020.
  5. Cunha-Oliveira, Teresa (7F1D-6E9A-C5EA); Silva, Filomena S.G.; Pinho, Sónia A; Costa, Cláudio F.; Miranda-Santos, I.; Oliveira, Paulo J (E41F-4FB7-5948). "Mitochondria as biosensors for disease staging and therapeutic response.". Paper presented in 54th Annual Meeting of the European Society for Clinical Investigation, Virtual Event., 2020.
  6. Soares, Pedro; Silva, Catia; Silva, Filomena S.G.; Batie, Michael; Oliveira, Catarina; Cagide, Fernando; Oliveira, Paulo J (E41F-4FB7-5948); Rocha, Sonia; Borges, Fernanda. "Mitochondriotropic antioxidants as novel therapeutics for ALS: development of multitarget agents to prevent stress induced MN death.". Paper presented in MuTaLig COST ACTION CA15135, 5th WG meeting, 2020.
  7. Silva, Filomena S.G.; Cunha-Oliveira, Teresa (7F1D-6E9A-C5EA); Bento, Guida; Lourenço, Nuno; Oliveira, Paulo J (E41F-4FB7-5948). "Data mining analysis of respiratory and glycolytic rates from amyotrophic lateral sclerosis patients: unravelling the effect of SOD1 mutation.". Paper presented in 2nd FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2019.
  8. Cho, Sunghyoun; Byeon, Haewon. "Alterations in mitochondrial biogenesis and regulation of morphology in lymphoblasts from amyotrophic lateral sclerosis patients". Paper presented in 2nd FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2019.
    10.14257/astl.2016.132.36
  9. Cho, Sunghyoun; Byeon, Haewon. "Understanding the influence of SOD1 mutation on mitochondrial mechanisms of autophagy and apoptosis in lymphoblasts from amyotrophic lateral sclerosis patients". Paper presented in 2nd FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2019.
    10.14257/astl.2016.132.36
  10. Leduc, A.. "Reprogramming forwards oxidative phosphorylation in breast cancer cell as potential drug targets". Paper presented in 2nd FEBS Advanced Lecture Course on Oncometabolism: From Conceptual Knowledge to Clinical Applications, 2019.
    10.1051/jtsfen/2016chi05p
  11. Silva, Filomena S.G.; Bento, Guida; Cunha-Oliveira, Teresa ; Oliveira, Paulo J. "Influence of SOD1 mutation on lymphoblast respiration and glycolytic rates from amyotrophic lateral sclerosis patients.". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation, 2019.
  12. Bento, Guida; Siewiera, Karolina; Montezinho, Liliana ; Oliveira, Paulo J ; Silva, Filomena SG. "Understanding the cell growth profile of lymphoblasts to study as a model to discover the amyotrophic lateral sclerosis disease mechanisms.". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation, 2019.
  13. Silva, Filomena S.G.; Komlodi, Timea; Garcia-Souza, Luiz F ; Oliveira, Paulo J ; Gnaiger, Erich. "Effect of etomoxir on mitochondrial function assessed by high-resolution respirometry.". Paper presented in 52th Annual Scientific Meeting of the European Society for Clinical Investigation, 2018.
  14. Silva, Filomena S.G.. "Establishing a new model for toxicological evaluation combining Sulforhodamine B and resazurin in human cells.". Paper presented in 50th Annual Scientific Meeting of the European Society for Clinical Investigation, 2016.
  15. Ribeiro MP; Silva FS; Sousa MC; Santos AE; Custódio JB. "Retinoids and antiestrogens: a new combined therapy for cancer treatment?". Paper presented in XX Porto Cancer Meeting, 2011.
  16. Ribeiro MP; Silva FS; Santos AE; Custódio JB. "Effects of endoxifen on mitochondrial functions". Paper presented in Targeting Mitochondria, 2011.
  17. Silva FS; Fernandes JC; Rocha-Pereira P; Custódio JB; Santos-Silva A. "Evaluation of the cytogenotoxic potential of isotretinoin and acitretin in cultured human blood lymphocytes in vitro". Paper presented in International Courses in Toxicology 2010 – Survival or Death as Matter of Fat, 2010.
  18. Silva FS; Fernandes JC; Rocha S; Rocha-Pereira P; Custódio JB; Santos-Silva A. "The cytogenotoxic effects of isotretinoin and acitretin on human lymphocytes cultures in vitro". Paper presented in IV Workshop em Bioquímica Clínica, 2010.
  19. Santos M; Almeida S; Silva FS; Santos-Silva E; Santos-Silva A; Rocha-Pereira P. "Baixo peso ao nascimento - O papel do laboratório na avaliação de fatores de risco para doença cardiovascular". Paper presented in 3º Congresso Cientifico da Associação Nacional de Laboratórios de Análises Clínicas, 2009.
  20. Capote TC; Silva FS; Marques PF; Santos-Silva A; Rocha-Pereira P; Custódio JB. "Effect of homocysteine in the mitochondrial permeability transition pore opening". Paper presented in Metabolic Toxicology: From Pathway to Organism. International Courses on Toxicology, 2008.
  21. Marques PF; Silva FS; Capote TC; Machado M; Sousa MC; Rocha-Pereira P; Custódio JB. "p-Cymene and 2-nitro-p-cymene effects on the oxidative phosphorylation of rat liver mitochondria". Paper presented in Metabolic Toxicology: From Pathway to Organism. International Courses on Toxicology, 2008.
  22. Silva FS; Marques PF; Capote TC; Machado M; Sousa MC; Rocha-Pereira P; Custódio JB. "Effects of essential oils constituent p-cymene on bioenergetic functions of rat liver mitochondria". Paper presented in 15th International Congress on in vitro toxicology, 2008.
  23. Silva FS; Santos MS; Sousa MC; Santos-Silva A; Rocha-Pereira P; Custódio JB. "Therapeutical association of retinoic acids with antiestrogenic compounds: potential application in therapy of inflammatory skin disorders and breast cancer". Paper presented in Workshop Bioquímica Clínica, Doenças Emergentes Século XXI, 2008.
  24. Silva FS; Sardão VA; Oliveira PJ; Santos MS; Sousa MC; Santos-Silva A; Rocha-Pereira P; Custódio JB. "Effect of 13-cis-RA and acitretin on tumour cell proliferation and isolated liver mitochondria". Paper presented in XVIth National Congresso of Biochemistry, 2008.
  25. Custódio JB; Silva FS; Capote TC; Marques RJ; Machado M; Rocha-Pereira P; Cavaleiro C; Sousa MC. "Essential oils constituent p-cymene induces proton leak in rat liver mitochondria". Paper presented in XVIth National Congresso of Biochemistry, 2008.
  26. Silva FS; Santos MS; Sousa MC; Santos-Silva A; Rocha-Pereira P; Custódio JB. "Effect of 13-cis-retinoic acid and acitretin on bioenergetic functions of rat liver mitochondria". Paper presented in XVIth National Congresso of Biochemistry, 2008.
  27. Santos M; Almeida S; Silva FS; Santos-Silva E; Santos-Silva A; Rocha-Pereira P. "Low birth weight –prognostic risk value". Paper presented in XVI National Congress of Biochemistry, 2008.
  28. Silva FS; Santos MS; Moreira PI; Santos-Silva A; Rocha-Pereira P; Custódio JB. "Effects of the 13-cis-retinoic acid on the oxidative phosphorylation of rat liver mitochondria". Paper presented in First Iberic Meeting on Medicinal Chemistry, 2007.
  29. Custódio JB; Silva FS; Moreira PI; Santos-Silva A; Rocha-Pereira P; Santos MS. "13-cis-retinoic acid interacting with adenosine nucleotide translocase causes mitochondrial permeability transition". Paper presented in First Iberic Meeting on Medicinal Chemistry, 2007.
  30. Silva FS; Carvalho C; Marques RJ; Santos-Silva A; Rocha-Pereira P. "O papel da diabetes mellitus na doença cardiovascular em mulheres pós-menopausicas". Paper presented in 10as Jornadas Científicas de Análises Clínicas, 2006.
Journal article
  1. Teresa Cunha-Oliveira; Liliana Montezinho; Catarina Mendes; Omidreza Firuzi; Luciano Saso; Paulo J. Oliveira; Filomena S. G. Silva; Jos L. Quiles. "Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention". Oxidative Medicine and Cellular Longevity 2020 (2020): 1-29. https://doi.org/10.1155/2020/5021694.
    10.1155/2020/5021694
  2. Silva, Filomena. "Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated H9c2 cardiomyoblasts.". Biochimica et biophysica acta (2017): http://europepmc.org/abstract/med/28760703.
    10.1016/j.bbadis.2017.07.030
  3. Silva, Filomena S. G.; Oliveira, Paulo J.; Duarte, Maria F.. "Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?". Journal of Agricultural and Food Chemistry 64 15 (2016): 2991-3008.
    Published • 10.1021/acs.jafc.5b06021
  4. Silva, Filomena S. G.; Simoes, Rui F.; Couto, Renata; Oliveira, Paulo J.. "Targeting Mitochondria in Cardiovascular Diseases". Current Pharmaceutical Design 22 37 (2016): 5698-5717. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000388519800006&KeyUID=WOS:000388519800006.
    10.2174/1381612822666160822150243
  5. Silva, Filomena. "Determination of Cell Mass and Viability Using a Dual Sulforhodamine B/resazurin Assay.". Curr Protoc Toxicol. (2016):
    10.1002/cptx.1
  6. Silva FS; Ribeiro MP; Santos MS; Rocha-Pereira P; Santos-Silva A; Custódio JB. "Acitretin affects bioenergetics of liver mitochondria and promotes mitochondrial permeability transition: Potential mechanisms of hepatotoxicity". Toxicology 306 -- (2013): 93-100.
    Published • 10.1016/j.tox.2013.01.020
  7. Silva FS; Oliveira H; Moreiras A; Fernandes JC; Bronze-da-Rocha E; Figueiredo A; Custódio JB; Rocha-Pereira P; Santos-Silva A. "Cytotoxic and genotoxic effects of acitretin, alone or in combination with psoralen–ultraviolet A or narrow-band ultraviolet B-therapy in psoriatic patients". Mutation Research/Genetic Toxicology and Environmental Mutagenesis 753 1 (2013): 42-47.
    Published • 10.1016/j.mrgentox.2012.12.017
  8. Ribeiro MP; Silva FS; Paixão J; Santos AE; Custódio JB. "The combination of the antiestrogen endoxifen with all-trans-retinoic acid has anti-proliferative and anti-migration effects on melanoma cells without inducing significant toxicity in non-neoplasic cells". European Journal of Pharmacology 715 -- (2013): 354-362.
    Published • 10.1016/j.ejphar.2013.04.038
  9. Silva FS; Ribeiro MP; Santos MS; Rocha-Pereira P; Santos-Silva A; Custódio JB. "The antiestrogen 4-hydroxytamoxifen protects against isotretinoin-induced permeability transition and bioenergetic dysfunction of liver mitochondria: comparison with tamoxifen". Journal of Bioenergetics and Biomembranes -- (2013): 383-396.
    Published • 10.1007/s10863-013-9517-9
  10. Ribeiro MP; Silva FS; Santos AE; Santos MS; Custódio JB. "The antiestrogen endoxifen protects rat liver mitochondria from permeability transition pore opening and oxidative stress at concentrations that do not affect the phosphorylation efficiency". Toxicology and Applied Pharmacology 267 1 (2013): 104-112.
    Published • 10.1016/j.taap.2012.12.012
  11. Silva, F.S.G.; Oliveira, H.; Moreiras, A.; Fernandes, J.C.; Bronze-da-Rocha, E.; Figueiredo, A.; Custódio, J.B.A.; Rocha-Pereira, P.; Santos-Silva, A.. "The in vitro and in vivo genotoxicity of isotretinoin assessed by cytokinesis blocked micronucleus assay and comet assay". Toxicology in Vitro 27 2 (2013): 900-907. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873165561&partnerID=MN8TOARS.
    10.1016/j.tiv.2013.01.002
  12. Silva, Filomena. "The essential oils component p-cymene induces proton leak through Fo-ATP synthase and uncoupling of mitochondrial respiration". Journal of Experimental Pharmacology (2011): http://www.dovepress.com/the-essential-oils-component-p-cymene-induces-proton-leak-through-fo-a-peer-reviewed-article-JEP.
    http://dx.doi.org/10.2147/JEP.S16387
Thesis / Dissertation
  1. Silva, Filomena S.G.. "Acitretin and isotretinoin: mitochondrial, cellular and cytogenotoxic studies. Combined action with antiestrogens, NBUVB or PUVA". PhD, Universidade de Coimbra, 2014.
  2. Silva, Filomena S.G.. ""Separation of plasmid DNA isoforms by pseudo-affinity chromatography with ligands L-histidine.". Degree, Universidade da Beira Interior, 2006.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/07/08 Off-target effects of etomoxir on mitochondrial complex I. 12th MiP/MitoEAGLE Training School 2019. Mitochondrial respiratory physiology: Challenges on data sharing, reproducibility, and interpretation.
(Coimbra, Portugal)
2019/05/22 Can fatty acid oxidation be specifically blocked by the CPT1 inhibitor etomoxir? Pre-congress session | MitoEAGLE COST Action: Mitochondrial - fitness mapping – Quality management network. 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Coimbra, Portugal)
2018/09/18 The unspecific effect of etomoxir on mitochondrial respiration. 13th Conference on Mitochondrial Physiology: The role of mitochondria in health, disease and drug discovery - COST MitoEAGLE perspectives and MitoEAGLE WG and MC Meeting
(Jurmala, Latvia)
2015/09/14 New valorization strategies for Eucalyptus spp. bark extracts. New valorization strategies for Eucalyptus spp. bark extracts, 3rd Edition of the International Conference WASTES: Solutions, Treatments and Opportunities
(Viana do Castelo, Portugal)
2014/11/13 Characterization of toxicological effects of acitretin alone or in combination with psoralen–ultraviolet A or narrow-band ultraviolet B- therapy. II Jornadas Ibéricas de Toxicologia
University of Beira Interior (Covilhã, Portugal)
2011 The combination of antiestrogens with retinoic acid does not enhance the toxic effects induced by the retinoid on bioenergetic functions XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião de Farmacologia Clínica, X Reunião de Toxicologia
(Coimbra, Portugal)
2011 Evaluation of the cytogenotoxic potential of acitretin in combination with antiestrogenic compounds on human lymphocytes cultures in vitro XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião de Farmacologia Clínica, X Reunião de Toxicologia
(Coimbra, Portugal)
2009 Inflamação, Dislipidémia, Hemostase- Que relação? 3º Congresso Cientifico da Associação Nacional de Laboratórios de Análises Clínicas
(Porto, Portugal)
2009 Adiponectina e risco cardiovascular em diabéticos tipo 2 3º Congresso Cientifico da Associação nacional de Laboratórios de Análises Clínicas
(Porto, Portugal)
2008/05/30 Estudo de novas estratégias terapêuticas no cancro da pele e da mama. Da Investigação à Pratica Clinica
University of Beira Interior (Covilhã, Portugal)
2008 Inhibition of the adenine nucleotide translocar by 13-cis-retinoic acid and acitretin in vitro Metabolic Toxicology: From Pathway to Organism. International Courses on Toxicology
(Coimbra, Portugal)
2008 Associação terapêutica de ácidos retinóicos e anti-estrogénios no cancro da pele e da mama: mecanismos moleculares de citotoxicidade 2º Congresso Cientifico da Associação Nacional de Laboratórios de Análises Clínicas
(Vilamoura, Portugal)
2008 Combined therapy of retinoic acids with antiestrogenic compounds: a potential application for therapy of inflammatory skin disorders and breast cancer XXXIX Reunião Anual da Sociedade Portuguesa de Farmacologia, XXVI Reunião de Farmacologia Clínica, VIII Reunião de Toxicologia
(Lisboa, Portugal)
2008 Effect of carbamazepine, homocysteine and homocysteine tiolactone in the mitochondrial permeability transition pore opening XXXIX Reunião Anual da Sociedade Portuguesa de Farmacologia, XXVI Reunião de Farmacologia Clínica, VIII Reunião de Toxicologia
(Lisboa, Portugal)
2007 13-cis-retinoic acid induces changes on the oxidative phosphorylation capacity of rat liver mitochondria XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXV Reunião de Farmacologia Clínica, VII Reunião de Toxicologia
(Coimbra, Portugal)
2007 Interactions of 13-cis-retinoic acid with adenosine nucleotide translocase mechanisms of mitochondrial permeability transition induction XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXV Reunião de Farmacologia Clínica, VII Reunião de Toxicologia
(Coimbra, Portugal)
2007 Effect of acitretin in the mitochondrial permeability transition pore opening XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXV Reunião de Farmacologia Clínica, VII Reunião de Toxicologia
(Coimbra, Portugal)
2007 p-Cymene and 2-nitro-p-cymene effects on the oxidative phosphorylation of rat liver mitochondria XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXV Reunião de Farmacologia Clínica, VII Reunião de Toxicologia
(Coimbra, Portugal)
2006 Plasmids production and purification by pseudo-affinity chromatography I CICS Symposium, Universidade da Beira Interior
(Covilhã, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/09 - 2020/05 Oxidative stress mechanisms and parameters of mitochondrial dysfunction in lymphoblasts from patients with Amyotrophic Lateral Sclerosis.
Supervisor
2019/04/29 - 2019/08/30 Alterations in mitochondrial biogenesis and regulation of morphology in lymphoblasts from Amyotrophic Lateral Sclerosis patients
Supervisor
 Biotechnology (Degree)
Polytecnic Institute of Coimbra, Coimbra College of Agriculture , Portugal
2019/04/29 - 2019/08/30 A influência da mutação da SOD1 nos mecanismos mitocondriais de autofagia e apoptose em linfoblastos de pacientes com esclerose lateral amiotrófica - "Influence of SOD1 mutation on the mitochondrial mechanisms of autophagy and apoptosis in lymphoblasts from patients with amyotrophic lateral sclerosis"
Supervisor
 Biotechnology (Degree)
Distinctions

Other distinction

2008 Prize awarded to the best oral paper presented in “2º Congresso Científico da Associação Nacional de Laboratórios Clínicos”
Associação Nacional de Laboratórios Clínicos, Portugal
2007 Merit Scholarship for the best classification of Biochemistry graduation
Universidade da Beira Interior, Portugal
2004 Merit Scholarship for the best student of Biochemistry graduation (2003/4)
Universidade da Beira Interior, Portugal