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João Camões dos Santos completed the Integrated Master¿s in Biological Engineering in 2022 by Instituto Superior Técnico (IST), Universidade de Lisboa, with a grade at the top of his class (19/20). His master thesis, titled "Using CRISPR/Cas9 to Generate an Isogenic Cell Line from Patient-Derived Induced Pluripotent Stem Cells to model Niemann-Pick type C1 Cerebellar Ataxia", was supervised by Dr. Evguenia Bekman and Prof. Tiago Fernandes, and graded 19 out of 20. His main scientific interest areas are genetic engineering; stem cell-based disease modeling; organoids and neuroscience. He has participated in 3 national and international congresses, where he presented posters on the work from his master thesis, and more recently on his work in Angelman Syndrome. For his excellent academic performance, he was awarded the ULisboa Merit Scolarship in 2021. He worked as a teaching assistant at IST for the Transport Phenomena in Biological Systems curricular unit, for three consecutive years, with very positive evaluation from the students (9 out of 9). He applied and was awarded with a research fellowship under the "Stem Cell tool kit for modelling cerebellar dysfunction in Angelman Syndrome" project, funded by the Angelman Syndrome Alliance, and co-supervised by Dr. Simão da Rocha and Dr. Evguenia Bekman. As a research assistant, he is currently working at the Stem Cell Engineering Research Group (SCERG) of the Institute for Bioengineering and Biosciences (iBB) on the generation of new induced pluripotent stem cells derived from Angelman syndrome patients and their parents, to be used in the derivation of organoid models of the disease. More recently he was co-authored a Review article titled "Stem cell models of Angelman Syndrome" in Frontiers in Cell and Developmental Biology (Impact factor: 6.081), published in October 2023.
Identification

Personal identification

Full name
João Rafael Camões dos Santos
Date of birth
1999/03/14
Gender
Male

Citation names

  • Camões dos Santos, João

Author identifiers

Ciência ID
D11B-8152-0CE0
ORCID iD
0000-0003-2913-3758

Email addresses

  • joao.r.camoes.santos@tecnico.ulisboa.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English
Education
Degree Classification
2024/02/01 - 2028/02/28
Ongoing
Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
"An Isogenic Stem Cell Toolkit to Advance Therapeutics in Angelman Syndrome" (THESIS/DISSERTATION)
2020/09 - 2022/11
Concluded
Engenharia Biológica (Mestrado integrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Using CRISPR-Cas9 to generate an isogenic cell line from patient-derived human induced pluripotent stem cells to model Niemann-Pick Type C1 Cerebellar Ataxia" (THESIS/DISSERTATION)
19
2017/09 - 2020/09
Concluded
Engenharia Biológica (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
18
Affiliation

Science

Category
Host institution
Employer
2023/01/23 - Current Research Assistant (Research) Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2024/11/09 - 2025/01/09 Assistant (University Teacher) Universidade de Lisboa Instituto Superior Técnico, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/09/14 - 2024/01/14 Assistant (University Teacher) Universidade de Lisboa Instituto Superior Técnico, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/10/01 - 2023/02/14 Tutor (University Teacher) Universidade de Lisboa Instituto Superior Técnico, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/10/01 - 2022/01/31 Tutor (University Teacher) Universidade de Lisboa Instituto Superior Técnico, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
Projects

Grant

Designation Funders
2023/09 - Current EUropean network for neurodevelopmental RASopathies (EURAS)
101080580
Assistance with gene editing experimental design and execution
Horizon Europe
Ongoing
2023/01/23 - Current Stem cell toolkit for modelling cerebellar dysfunction in Angelman Syndrome
1801P.01215
Research Fellow
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Angelman Syndrome Alliance
Ongoing
Outputs

Publications

Conference poster
  1. Camões dos Santos, João; Cazaux Mateus, Francisca; Arez, Maria; Bekman, Evguenia P.; da Rocha, Simão T.. Corresponding author: da Rocha, Simão T.. "Stem Cell Toolkit to Advance Therapeutics in Angelman Syndrome". Paper presented in 2024 ISSCR Annual Meeting, 2024.
  2. Cazaux Mateus, Francisca; Camões dos Santos, João; Arez, Maria; Bekman, Evguenia; da Rocha, Simão T.. "A novel Stem Cell Model for Angelman Syndrome caused by Paternal Uniparental Disomy of Chromosome 15". Paper presented in IBB Meeting 2023, 2023.
  3. Camões dos Santos, João. "Stem Cell Toolkit to Advance Therapeutics in Angelman Syndrome". Paper presented in ETRS & SPCE-TC 2023 Joint Meeting, 2023.
  4. Cazaux Mateus, Francisca; Camões dos Santos, João; Arez, Maria; Bekman, Evguenia; da Rocha, Simão T.. "Stem Cell-Based Disease Modeling Of Angelman Syndrome Caused by Paternal Uniparental Disomy for Chromosome 15". Paper presented in SPCE-ETRS Joint Annual Meeting 2023, 2023.
  5. Camões dos Santos, João. "Using CRISPR-Cas9 to generate an isogenic cell line from patient-derived human induced pluripotent stem cells to model Niemann-Pick type C1 cerebellar ataxia". Paper presented in 2nd iBB Workshop, 2022.
Journal article
  1. Camões dos Santos, João; Appleton, Carolina; Cazaux Mateus, Francisca; Covas, Rita; Bekman, Evguenia P.; da Rocha, Simão T.. Corresponding author: da Rocha, Simão T.. "Stem cell models of Angelman syndrome". Frontiers in Cell and Developmental Biology 11 (2023):
    Open access • Published
Activities

Event participation

Activity description
Type of event
Event name
Institution / Organization
2024/08/01 - 2024/08/03 Angelman Syndrome Alliance (ASA) Scientific Meeting held in Coventry, United Kingdom
Conference
2024 ASA Scientific Meeting
Angelman Syndrome Alliance, Netherlands
2024/07/10 - 2024/07/13 Annual meeting of the International Society for Stem Cell Research (ISSCR2024)
Conference
2024 ISSCR Annual Meeting
International Society for Stem Cell Research, United States
2023/10/11 - 2023/10/13 ETRS & SPCE-TC 2023 Joint Meeting
Conference
ETRS & SPCE-TC 2023 Joint Meeting
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal
2023/03/01 - 2023/03/03 Building Bridges in Biology Symposium
Symposium
Building Bridges in Biology
Instituto Gulbenkian de Ciência, Portugal
2022/09/23 - 2022/09/23 2nd iBB Workshop
Conference
2nd iBB Workshop
Universidade de Lisboa Instituto Superior Técnico, Portugal

Association member

Society Organization name Role
2018 - 2022 Núcleo de Estudantes de Engenharia Biológica Collaborator of the Repository Department
Distinctions

Other distinction

2021 ULisboa Merit Scholarship
Universidade de Lisboa, Portugal