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Daniela M. Sousa concluded her Ph.D in Biomedical Engineering from the Faculty of Engineering of the University of Porto in 2012. She is currently a Postdoctoral Fellow at the Neuro & Skeletal Circuits Group, led by Meriem Lamghari at i3S (Instituto de Investigação e Inovação em Saúde) and the leader of the Sympathetic Team. In the framework of her Ph.D research, Daniela focused her studies on the pharmacological potential of targeting a specific neuropeptide receptor, as a clinical therapeutic strategy to modulate bone regeneration/repair. These studies led her to join the Neuroscience Group and Bone Research Group at the Garvan institute of Medical Research (Sydney, Australia), where she was able to consolidate her scientific path on the characterization of bone phenotype by means of using murine knockout and bone fracture models. Currently, Daniela has been enrolled in deepening the role of the sympathetic nervous system and the adrenergic signaling pathways in the progression of osteolytic lesions in breast cancer bone metastasis. In the framework of her research, she has developed in vivo mouse bone models to study bone metastasis, fracture and regeneration as well as in vitro 3D models in microfluidic devices for skeletal-non skeletal cells communication studies. Daniela authored 32 papers in international peer-reviewed journals and 1 book chapter with a total of 688 citations (h-index 15; Source: SCOPUS). She has established several national and international collaborations that resulted in several joint publications. Currently, Daniela is the principal investigator of a financed project and has been participating as team member in 12 projects (8 national and 4 international). She supervised and co-supervised 1 PhD and several MSc thesis (including 4 ERASMUS students), and undergraduate trainees. She is ad hoc reviewer for several international journals. Daniela has been awarded with an ECTS New Investigator Award in recognition of outstanding work, by the European Calcified Tissue Society (2014). She participate regularly in several public exhibitions, school visits and open days. Daniela was the co-founder and current coordinator of the i3S GreenLab Initiative, which aims to implement green laboratory practices at i3S.
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Identification

Personal identification

Full name
Daniela dos Santos Monteiro e Sousa

Citation names

  • Sousa, Daniela
  • Daniela M. Sousa
  • Monteiro-Sousa, D.

Author identifiers

Ciência ID
D411-F413-30B0
ORCID iD
0000-0001-8498-0664

Email addresses

  • danisous@ineb.up.pt (Professional)

Telephones

Telephone
  • 220408800 Ext.: 7130 (Professional)

Addresses

  • Neuro & Skeletal Circuits (NeSK) Group, Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biology
  • Medical and Health Sciences - Health Sciences
  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Elementary (A2) Beginner (A1) Elementary (A2) Beginner (A1)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2023
Concluded
 Course in Research Project management (Curso de Especialização Tecnológica)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021 - 2022
Concluded
 Training Course in Research Ethics & Integrity (Curso de Especialização Tecnológica)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014
Concluded
 Training Course in mouse/rat Perfusion (Curso de Especialização Tecnológica)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2013
Concluded
 Training Course in mice and rat blood collection (Curso de Especialização Tecnológica)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2008 - 2012
Concluded
 PhD in Biomedical Engineering (Doutoramento)
Universidade do Porto Faculdade de Engenharia, Portugal
"NPY signalling pathway in bone homeostasis: Y1 receptor as a potential drug target" (THESIS/DISSERTATION)
 Aprovado com distinção
2009
Concluded
 Course in Laboratory Animal Science - FELASA Category C (Curso de Especialização Tecnológica)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2006 - 2007
Concluded
 MSc in Toxicology and Ecotoxicology (Mestrado)
Universidade de Aveiro Departamento de Biologia, Portugal
"Efeitos miocárdicos da Endotelina-1 na insuficiência cardíaca" (THESIS/DISSERTATION)
 17
2001 - 2006
Concluded
 BSc in Biology (Licenciatura)
Universidade de Aveiro Departamento de Biologia, Portugal
 16
Affiliation

Science

Category
Host institution 		Employer
2017 - Current Postdoc (Research) i3S/INEB, Portugal
i3S/INEB, Portugal
2016 - 2017 Contracted Researcher (Research) i3S/INEB, Portugal
2013 - 2016 Postdoc (Research) Instituto Nacional de Engenharia Biomédica, Portugal
2008/01/01 - 2012/11/13 Research Trainee (Research) Instituto Nacional de Engenharia Biomédica, Portugal
Instituto Nacional de Engenharia Biomédica, Portugal
2010 - 2011 Visiting Researcher (Research) Garvan Institute of Medical Research, Australia
2005 - 2007 Research Trainee (Research) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2004 - 2005 Research Trainee (Research) Universidade de Aveiro, Portugal
Universidade de Aveiro Departamento de Biologia, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2012 - 2013 Invited Assistant (University Teacher) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal

Positions / Appointments

Category
Host institution 		Employer
2020/04 - 2020/08 Volunteer to perform PCR tests - (as part of The NATIONAL TASK FORCE FOR COVID19) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Others

Category
Host institution 		Employer
2022 - Current Member of the Board of Reviewing Editors of Frontiers in Molecular BioSciences Frontiers Media SA, Switzerland
2021/03 - 2021/07 Maternity Leave i3S/INEB, Portugal
2017/06 - 2017/10 Maternity Leave i3S/INEB, Portugal
Projects

Grant

Designation Funders
2022/01/01 - Current BoneMetas - STRESS AND BREAST CANCER METASTASIS TO BONE: Exploring the Yin-Yang of sympathetic adrenergic signaling
EXPL/BIA-BQM/0255/2021
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e Tecnologia (FCT)
Ongoing
2022 - Current SINPAIN - A game changer for the treatment of osteoarthritis: a cost effective combined advanced therapy to treat knee osteoarthritis
101057778
Researcher
Horizon 2020
Ongoing
2021 - Current FLAMIN-GO - From pathobioLogy to synoviA on chip: driving rheuMatoId arthritis to the precisioN medicine GOal
953121
Researcher
Horizon 2020
Ongoing
2022 - 2024 Bone SAAver: Identification of mechanisms and biomarkers of bone loss in patients with Cystic Fibrosis
003055G221
Researcher
Cystic Fibrosis Foundation
Ongoing
2018 - 2022 SproutOC - Pathological nerve sprouting in bone metastases: OSTEOCLASTS, what are you doing?
PTDC/MED-PAT/30158/2017
Researcher
i3S/INEB, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/07/01 - 2021/12/31 AntINFECT - Bioengineered Advanced Therapies for Problematic Infected Wounds
PTDC/NAN-MAT/31781/2017
Researcher
Instituto Nacional de Engenharia Biomédica, Portugal
 Fundação para a Ciência e Tecnologia (FCT)
Concluded
2016 - 2019 MiNerv - Sensory innervation in the complex orchestration of bone regeneration: interplay in microfluidics platforms
PTDC/BIM­MED/4041/2014
Researcher
Fundação para a Ciência e Tecnologia (FCT), Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2015 YTag - Y1 receptor based therapy for local bone repair - Antagonist behaviour and delivery in challenged bone microenvironment.
PTDC/BIM-MED/1047/2012
Researcher
Fundação para a Ciência e Tecnologia (FCT)
2012 - 2013 MIMESIS - Marine invertebrate models & engineered substrates for innovative bio- scaffolds
MIMESIS
Post-doc Fellow
Fondazione Cariplo
2010 - 2013 NPwhY - Innervation and angiogenesis for the benefit of osteogenesis - the involvement of NPY neuronal pathway in bone repair
PTDC/SAU-OSM/101469/2008
 Fundação para a Ciência e Tecnologia (FCT)
Concluded
2008/01 - 2011/12 NPY signalling Pathway in Bone Homeostasis: Y1 receptor as a Drug Target
SFRH/BD/37654/2007
PhD Student Fellow
Fundação para a Ciência e Tecnologia (FCT)
2005 - 2007 Modulation of myocardial diastolic properties by endothelin-1 and angiotensin II - Pathophysiologic and therapeutic implications in heart failure.
POCI/SAU-FCF/60803/2004
Master Student Fellow
Fundação para a Ciência e Tecnologia (FCT)
Concluded

Contract

Designation Funders
2023/12/01 - Current Blood as energy source to power smart cardiac devices
Grant agreement ID: 101115525
Post-doc Fellow
2021/01/01 - 2025/12/31 Institute for Research and Innovation in Health
LA/P/0070/2020
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2021/06/30 Pathological nerve sprouting in bone metastases: OSTEOCLASTS, what are you doing
PTDC/MED-PAT/30158/2017
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Instituto de Investigação e Inovação em Saúde
UID/BIM/04293/2019
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/05 - 2017/04 In-vivo approaches in Neuroscience: Development of animal models and research infrastructures
i3S.NEURO_RL3_IASE_01_2016
Post-doc Fellow
i3S/INEB
2011/01/01 - 2012/12/31 Strategic Project - LA 2 - 2011-2012
PEst-C/SAU/LA0002/2011
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Caldeira, J.; Sousa, A.; Sousa, D.M.; Barros, D.. "Extracellular matrix constitution and function for tissue regeneration and repair". 29-72. 2018.
Conference paper
  1. Sousa DM, Conceição F, Silva DI, Alencastre IS, Nave J, Neto E, Alves CJ, McDonald MM, Baldock PA, Herzog H, Lamghari M. "Exploring a Novel Y1 Receptor-Based Therapeutic Strategy for Bone Regeneration". 2015.
  2. Sousa DM, Leite DM, Neto E, Silva DI, Martins J, Alencastre IS, Alves CJ, Pego AP, Lamghari M. "Design of Nanoparticle-Delivery Systems for Bone Therapies". 2015.
  3. Martins, J.P.; Alves, C.J.; Neto, E.; Moreira, D.M.; Xavier, M.; Sousa, D.; Alencastre, I.; Lamghari, M.. "An in vitro approach to unravel the modulation of the hypothalamic system by blood-circulating factors". 2015.
    10.1109/ENBENG.2015.7088886
  4. Sousa DM, Baldock PA, Henriquez RE, Lamghari M, Herzog H. "Neuropeptide Y Y1 receptor antagonism: a novel anabolic tool for bone regeneration". 2014.
  5. Sousa DM, McDonald MM, Mikulec K, Peacock L, Little DG, Herzog H, Lamghari M, Baldock PA. "The role of Neuropeptide Y Y1 receptor signalling in fracture healing". 2014.
  6. Alencastre I, Almeida C, Leite D, Alves CM, Sousa DM, Neto E, Lamghari M. "Characterization of an Y1R antagonist as a drug for bone regeneration". 2013.
  7. Teixeira L, Sousa DM, Nunes AF, Mendes-Sousa M, Herzog H, Lamghari M. "Neuronal signaling and the regulation of bone remodeling new insights into the role of neuropeptide Y Y1 and Y2 receptors in osteoblast function". 2009.
  8. Sousa DM, Lamghari M. "Osteoblast proliferation and apoptosis: role of Neuropeptide Y and Y1 receptor". 2009.
  9. Brás-Silva, Monteiro-Sousa D, Duarte AJ, Leite-Moreira AF. "Functional evidence for the existence of ETA and ETB receptor crosstalk in the heart". 2007.
  10. Martins J, Pires AL, Ladeiras-Lopes R, Monteiro-Sousa D, Brás-Silva C, Leite-Moreira A. "Time dependent increase in myocardial distensibility after acute muscle stretch: the diastolic side of anrep effect". 2007.
  11. Brás-Silva, Duarte AJ, Monteiro-Sousa D, Leite-Moreira AF. "Urocortin 2 acutely decreases myocardial stiffness". 2007.
  12. Brás-Silva, Monteiro-Sousa D, Duarte AJ, Leite-Moreira AF. "Functional evidence for the existence of ETA and ETB receptor crostalk in the heart". 2007.
  13. Martins J, Pires AL, Ladeiras-Lopes R, Monteiro-Sousa D, Brás-Silva C, Leite-Moreira A. "Time dependent increase in myocardial distensibility after an acute preload elevation". 2007.
  14. Brás-Silva C, Monteiro-Sousa D, Duarte AJ, Leite-Moreira AF. "Evidência funcional para a existência de interacção dos receptores ETA e ETB no coração". 2007.
  15. Brás-Silva C, Duarte AJ, Monteiro-Sousa D, Leite-Moreira AF. "Efeitos Miocárdicos da Urocortina 2". 2007.
  16. Fontes-Sousa AP, Brás-Silva C, Pires AL, Monteiro-Sousa D, Leite-Moreira AF. "Mecanismos subjacentes ao aumento da distensibilidade miocárdica induzida pela urotensina II". 2007.
  17. Brás-Silva C, Castro-Chaves P, Monteiro-Sousa D, Duarte AJ, Nunes P, Fontes-Sousa AP, Leite-Moreira AF. "Disturbed myocardial response to endothelin-1 and angiotensin II in heart failure". 2006.
  18. Brás-Silva C, Duarte AJ, Monteiro-Sousa D, Fontes-Sousa AP, Leite-Moreira AF. "Endothelin-1 increases myocardial distensibility through nitric oxide prostaglandins release". 2006.
  19. Fontes-Sousa AP, Brás-Silva C, Pires A, Monteiro-Sousa D, Leite-Moreira AF. "Urotensin II: a novel neurohumoral modulator of diastolic function". 2006.
  20. Fontes-Sousa AP, Brás-Silva C, Pires AL, Monteiro-Sousa D, Leite-Moreira AF. "Urotensin II: a novel neurohumoral modulator of diastolic function". 2006.
  21. Brás-Silva C, Castro-Chaves P, Fontes-Sousa AP, Nunes P, Monteiro-Sousa D, Duarte AJ, Leite-Moreira AF. "Impaired systolic and diastolic myocardial response to ET-1 and AngII in heart failure". 2006.
  22. "NO and prostaglandins are required for the increase in myocardial distensibility induced by ET-1". 2006.
  23. Brás-Silva C, Monteiro-Sousa D, Duarte AJ, Fontes-Sousa AP, Leite-Moreira AF. "NO and prostaglandins are required for the increase in myocardial distensibility induced by ET-1". 2006.
  24. Fontes-Sousa A P, Bras-Silva C, Monteiro-Sousa D, Leite-Moreira AF. "Urotensin II as a novel neurohumoral modulator of diastolic function". 2006.
  25. Fontes-Sousa AP, Brás-Silva C, Monteiro-Sousa D, Leite-Moreira AF. "Urotensin II as a novel neurohumoral modulator of diastolic function". 2006.
  26. Brás-Silva C, Monteiro-Sousa D, Fontes-Sousa AP, Leite-Moreira AF. "The increase in myocardial distensibility induced by ET-1 is dependent on NO and prostaglandins release". 2006.
  27. Brás-Silva C, Castro-Chaves P, Fontes-Sousa AP, Nunes P, Monteiro-Sousa D, Duarte AJ, Leite-Moreira AF. "Atenuação da resposta miocárdica à endotelina-1 e à angiotensina II com evidência de disfunção endotelial endocárdica na insuficiência cardíaca". 2006.
  28. Brás-Silva C, Monteiro-Sousa D, Duarte AJ, Fontes-Sousa AP, Leite-Moreira AF. "O aumento da distensibilidade miocárdica induzido pela endotelina-1 depende da libertação endotelial de NO e prostaglandinas". 2006.
  29. Fontes-Sousa AP, Brás-Silva C, Monteiro-Sousa D, Leite-Moreira AF. "Urotensina II: um novo modulador neurohumoral da função diastólica". 2006.
Conference poster
  1. Daniela M. Sousa; Lamghari, Meriem. "Exploring an in vivo Stress model on Breast Cancer Bone Metastasis". Paper presented in 1st IMMUNO-model COST Action Conference, 2023.
  2. F. Conceição, D. M. Sousa, J. Loessberg-Zahl, A. Vollertsen, A. Leferink, M. Lamghari. "A Metastasis-On-a-Chip Approach to Explore the Sympathetic Control of Breast Cancer Bone Metastasis". Paper presented in EUROoCs conference 2022 (Grenoble, France), 2022.
  3. F. Conceição, D.M. Sousa, J. Loessberg-Zahl, A. Vollertsen, E. Neto, L. Leitão, C. J. Alves, A. Leferink, M. Lamghari. "Modelling the effect of sympathetic stimuli on the bone metastatic niche: a new microfluidic model". Paper presented in 4th PhDay: Break borders and build opportunities (Porto, Portugal), 2021.
  4. L. Leitão, F. Conceição, E. Neto, A.C. Monteiro, M. Couto, C. J. Alves, D. M. Sousa, M. Lamghari. "Osteoblasts are inherently programmed to repel sensory innervation". Paper presented in Cie^ncia21 – Encontro com a cie^ncia e tecnologia em Portugal (Lisboa, Portugal), 2021.
  5. F. Conceição, D. M. Sousa, J. Loessberg-Zahl, A. Vollertsen, E. Neto, L. Leitão, C. J. Alves, A. Leferink, M. Lamghar. "Exploring the bone metastatic niche: a new microfluidic model". Paper presented in 3rd PhDay: Back to the Future (Porto, Portugal), 2020.
  6. F. Conceição, D. M. Sousa, A. R. Pereira, L. Leitão, E. Neto, C. J. Alves, M. Lamghari. "ß2- Adrenergic Receptor on Osteoclast resorption: a player on bone metastasis?". Paper presented in 2º encontro 3CCB (Porto, Portugal), 2019.
  7. Neto E, Simões M, Leitão L, Sousa DM, Alves CJ, Conceição F, Chu V, Conde JP and Lamghari M. "Bone cells interaction at microfluidic platforms: establishment of tri-culture models to mimic bone innervation and vascularization". Paper presented in Workshop 2019, COST Action CA16119 CellFit “Cells communicate!” (Belgrade, Serbia), 2019.
  8. F.Conceição, D. M. Sousa, C. Lourenço, A. R. Pereira, L. Leitão, E. Neto, C. J. Alves, I. S. Alencastre, M. Lamghari. "ß2-AR in breast cancer-bone metastases: a novel microfluidic approach". Paper presented in 1st I3S PhDay (Porto, Portugal), 2018.
  9. Leitão L, Neto E, Sousa DM, Conceição F, Lourenço C, Simões M, Alves CJ, Alencastre IS, Lamghari M. "Effect of the secretome of osteoblastic-lineage cells on axonal outgrowth of sensory neurons". Paper presented in 1st 3CCB Meeting (Porto, Portugal), 2018.
  10. Alves CJ, Ribeiro-da-Silva M, Vasconcelos DM, Mateus A, Neto E, Leitão L, Conceição F, Sousa DM, Alencastre IS, Henrique. "The interplay between sympathetic signalling and inflammation in aseptic loosening of hip joint replacement". Paper presented in I3S Annual Meeting 2017, 2017.
  11. Conceição, Francisco; Daniela M. Sousa; Alves, Cecília J; I. S. Alencastre; Aguiar, Paulo; Lamghari, Meriem. "The Deficiency of Y1 Receptor Signalling Leads to Defective Osteoclast Bone-Resorbing Activity". Paper presented in GPCR-Ligand Interactions, Structures, and Transmembrane Signalling: a European Research Network (GLISTEN) Symposium, 2017.
  12. NETO, ESTRELA; D. Paramos; Daniela M. Sousa; Conceição, Francisco; L. Leitão; Lamghari, Meriem. "Osteoclasts culture in compartmantalized microfluidic platforms and bone-like mineralized substrates". Paper presented in 10th World Biomaterials Congress, 2016.
  13. Conceição F, Sousa DM, Aguiar P, Lamghari M.. "Computational Tool for Bone Resorption Analysis.". Paper presented in 4th International Symposium in Applied Bioimaging (Porto, Portugal), 2015.
  14. Conceição, Francisco; Daniela M. Sousa; Aguiar, Paulo; Lamghari, Meriem. "A Computational Tool for Bone Resorption Analysis". Paper presented in 4th International Symposium in applied Bioimaging, 2015.
  15. Sousa DM, Conceição F, Silva DI, Alencastre IS, Nave J, Neto E, Alves CJ, McDonald MM, Baldock PA, Herzog H, Lamghari M. "Exploring a Novel Y1 Receptor-Based Therapeutic Strategy for Bone Regeneration.". Paper presented in TERMIS World Congress (Boston - Massachusetts, USA), 2015.
  16. Sousa DM, Leite DM, Neto E, Silva D, Martins J, Alencastre IS, Alves CJ, Pego AP, Lamghari M. "Design of Nanoparticle-Delivery Systems for Bone Therapies". Paper presented in 4th Joint Meeting of European Calcified Tissue Society (ECTS) and the International Bone and Mineral Society (IBMS) (Rotterdam, The Netherlands), 2015.
  17. Neto E, Sousa DM, Alves CJ, Alencastre IS, Martins J, Aguiar P, Lamghari M. "Microfluidic-Based Co-Cultures: an Open Door to Bone Innervation Studies". Paper presented in 4th Joint Meeting of European Calcified Tissue Society (ECTS) and the International Bone and Mineral Society (IBMS) (Rotterdam, The Netherlands), 2015.
  18. Pinto A, Gonçalves C, Sousa DM, Moreira A, Gonçalves I, Magalhães F. "Effect of Size and Oxidation in Biocompatibility of Graphene-based Materials". Paper presented in 12th International Chemical and Biological Engineering Conference (ChemPor) (Porto, Portugal), 2014.
  19. Neto E, Paramos D, Silva D, Sousa DM, Alves CJ, Alencastre I, Aguiar P and Lamghari M. "Sensorial innervation and bone cells: the treasured relation disclosed in microfluidic platforms". Paper presented in Conference Series Microfluidics (Heidelberg, Germany), 2014.
  20. Martins JP, Alves CJ, Neto E, Sousa DM, Leite D, Xavier M, Alencastre I and Lamghari M. "In vitro tools to explore the communication between injured bone and nervous system: the humoral pathway". Paper presented in IJUP, 7º xi Encontro de Investigação Jovem da Universidade do Porto (Porto, Prtugal), 2014.
  21. Sousa DM, McDonald MM, Herzog H, Baldock PA and Lamghari M. "Imaging techniques and Bone Research: Exploring Tools to Study Fracture Healing in Y1 Receptor Knockout Models". Paper presented in 2nd International Symposium on Applied Bioimaging (Porto, Portugal), 2013.
  22. Alencastre I, Almeida C, Leite D, Alves CM, Sousa DM, Neto E and Lamghari M. "Characterization of an Y1R antagonist as a drug for bone regeneration". Paper presented in 0th European Symposium on Calcified Tissues (Lisbon, Portugal), 2013.
  23. Sousa DM, Baldock PA, Enriquez RF, Sainsbury A, Lamghari M, Herzog H. "Therapeutic effects of orally administered Y1 receptor antagonist in bone mass". Paper presented in I3S scientific retreat (Póvoa do Varzim, Portugal), 2012.
  24. Sousa DM, Enriquez R, Sainsbury A, Baldock PA, Lamghari M, Herzog H. "Y1 receptor antagonism increases bone formation in mice". Paper presented in JBMR Annual Meeting (San Diego, USA), 2011.
  25. Lee N, Sousa DM, Sainsbury A, Baldock PA, Herzog H. "NPY signalling in osteoblats controls glucose metabolism in mice". Paper presented in ENDO 93rd Annual Meeting (Boston, USA), 2011.
  26. Sousa DM, Neto EC, Estêvão MI, Lamghari M. "Role of NPY Y1 receptor signalling blockade on osteoblast activity". Paper presented in XII Meeting Portuguese Society for Neuroscience (Lisbon, Portugal), 2011.
  27. Sousa DM, Neto EC, Estêvão MI, Lamghari M. "Role of NPY Y1 receptor signalling blockade on osteoblast activity". Paper presented in ANZBMS 20th Annual Scientific Meeting (Adelaide, Australia), 2010.
  28. Sousa DM, Neto E, Estêvão M, Rocha D, Summavielle T, Herzog H and Lamghari M. "Neuropeptide Y1 receptor signaling blockbade modulates osteoblast proliferation and survival". Paper presented in I3S scientific retreat (Póvoa do Varzim, Portugal), 2010.
  29. Sousa DM, Neto E, Lamghari M. "Neuropeptide Y stimulates osteoblast proliferation: role of Y1 receptor". Paper presented in 10th Advanced Summer Course in Cell-Materials Interactions: from nature to clinics lectures (Porto, Portugal), 2009.
  30. Teixeira L, Sousa DM, Nunes AF, Sousa MM, Herzog H, Lamghari M. "Neuronal signaling and the regulation of bone remodeling. New insights into the role of Neuropeptide Y Y1 and Y2 receptors in osteoblast function". Paper presented in 11th Meeting Portuguese Society for Neurosciences (Braga, Portugal), 2009.
  31. Sousa DM, Lamghari M. "Osteoblast proliferation and apoptosis: role of Neuropeptide Y and Y1 receptor". Paper presented in 36th European Symposium on Calcified Tissues (Vienna, Austria), 2009.
  32. Sousa DM, Lamghari M. "Neuropeptide Y stimulates osteoblast proliferation: role of Y1 receptor". Paper presented in 9th Advanced Summer Course in Cell-Materials Interactions: Bioinspired matrices for tissue regeneration (Porto, Portugal), 2008.
  33. Fontes-Sousa AP, Brás-Silva C, Pires AL, Monteiro-Sousa D, Leite-Moreira AF. "The acute decrease of myocardial stiffness induced by the release by urotensin II is dependent on the activation of its receptor and the release of nitric oxide and prostaglandins". Paper presented in XI Workshop of the ESH Young Investigator Initiative Group (Milan, Italy), 2007.
  34. Brás-Silva, Monteiro-Sousa D, Duarte AJ, Leite-Moreira AF. "Functional evidence for the existence of ETA and ETB receptor crosstalk in the heart". Paper presented in Seventeenth European Meeting on Hypertension (Milan, Italy), 2007.
  35. Martins J, Pires AL, Ladeiras-Lopes R, Monteiro-Sousa D, Brás-Silva C, Leite-Moreira A. "Time dependent increase in myocardial distensibility after acute muscle stretch: the diastolic side of anrep effect". Paper presented in Seventeenth European Meeting on Hypertension (Milan, Italy), 2007.
  36. Brás-Silva, Monteiro-Sousa D, Duarte AJ, Leite-Moreira AF. "Functional evidence for the existence of ETA and ETB receptor crosstalk in the heart". Paper presented in Heart Failure (Hamburg, Germany), 2007.
  37. Brás-Silva, Duarte AJ, Monteiro-Sousa D, Leite-Moreira AF. "Urocortin 2 acutely decreases myocardial stiffness". Paper presented in Heart Failure (Hamburg, Germany), 2007.
  38. Martins J, Pires AL, Ladeiras-Lopes R, Monteiro-Sousa D, Brás-Silva C, Leite-Moreira A. "Time dependent increase in myocardial distensibility after an acute preload elevation". Paper presented in Heart Failure (Hamburg, Germany), 2007.
  39. Brás-Silva C, Monteiro-Sousa D, Duarte AJ, Leite-Moreira AF. "Evidência funcional para a existência de interacção dos receptores ETA e ETB no coração". Paper presented in XXVIII Congresso Português de Cardiologia (Vilamoura, Portugal), 2007.
  40. Fontes-Sousa AP, Brás-Silva C, Pires AL, Monteiro-Sousa D, Leite-Moreira AF. "Mecanismos subjacentes ao aumento da distensibilidade miocárdica induzida pela urotensina II". Paper presented in XXVIII Congresso Português de Cardiologia (Vilamoura, Portugal), 2007.
  41. Brás-Silva C, Castro-Chaves P, Monteiro-Sousa D, Duarte AJ, Nunes P, Fontes-Sousa AP, Leite-Moreira AF. "Disturbed myocardial response to endothelin-1 and angiotensin II in heart failure". Paper presented in 79th Scientific Sessions of the American Heart Association (Chicago, IL, USA), 2006.
  42. Fontes-Sousa AP, Brás-Silva C, Pires A, Monteiro-Sousa D, Leite-Moreira AF. "Urotensin II: a novel neurohumoral modulator of diastolic function". Paper presented in 79th Scientific Sessions of the American Heart Association (Chicago, IL, USA), 2006.
  43. Brás-Silva C, Duarte AJ, Monteiro-Sousa D, Fontes-Sousa AP, Leite-Moreira AF. "Endothelin-1 increases myocardial distensibility through nitric oxide prostaglandins release". Paper presented in 79th Scientific Sessions of the American Heart Association (Chicago, IL, USA), 2006.
  44. Brás-Silva C, Castro-Chaves P, Fontes-Sousa AP, Nunes P, Monteiro-Sousa D, Duarte AJ, Leite-Moreira AF. "Impaired systolic and diastolic myocardial response to ET-1 and Ang II in heart failure". Paper presented in Heart Failure (Helsinki, Finland), 2006.
  45. Brás-Silva C, Monteiro-Sousa D, Duarte AJ, Fontes-Sousa AP, Leite-Moreira AF. "NO and prostaglandins are required for the increase in myocardial distensibility induced by ET-1". Paper presented in Heart Failure (Helsinki, Finland), 2006.
  46. Fontes-Sousa A P, Bras-Silva C, Monteiro-Sousa D, Leite-Moreira AF. "Urotensin II as a novel neurohumoral modulator of diastolic function". Paper presented in Heart Failure (Helsinki, Finland), 2006.
  47. Fontes-Sousa A P, Brás-Silva C, Monteiro-Sousa D, Leite-Moreira AF. "Urotensin II as a novel neurohumoral modulator of diastolic function". Paper presented in Sixteenth European Meeting on Hypertension (Madrid, Spain), 2006.
  48. Brás-Silva C, Castro-Chaves P, Fontes-Sousa AP, Nunes P, Monteiro-Sousa D, Duarte AJ, Leite-Moreira AF. "Atenuação da resposta miocárdica à endotelina-1 e à angiotensina II com evidência de disfunção endotelial endocárdica na insuficiência cardíaca". Paper presented in XXVII Congresso Português de Cardiologia (Vilamoura, Portugal), 2006.
Journal article
  1. Sousa, D. M.; Cordeiro, Ana; Oliveira, Tiago Carvalho; Fonseca, Óscar; Pinto, Ricardo J.; Silvério, Diogo; Fernandes, Ana Isabel; et al. "Serum amyloid A proteins reduce bone mass during mycobacterial infections". Frontiers in Immunology 14 (2023): http://dx.doi.org/10.3389/fimmu.2023.1168607.
    10.3389/fimmu.2023.1168607
  2. Francisco Conceição; Daniela M. Sousa; Sofia Tojal; Catarina Lourenço; Carina Carvalho-Maia; Helena Estevão-Pereira; João Lobo; et al. "The Secretome of Parental and Bone Metastatic Breast Cancer Elicits Distinct Effects in Human Osteoclast Activity after Activation of ß2 Adrenergic Signaling". Biomolecules (2023): https://doi.org/10.3390/biom13040622.
    10.3390/biom13040622
  3. Daniela M. Sousa; Veronica Fernandes; Catarina Lourenço; Carina Carvalho-Maia; Helena Estevão-Pereira; João Lobo; Mariana Cantante; et al. "Profiling the Adrenergic System in Breast Cancer and the Development of Metastasis". Cancers (2022): https://doi.org/10.3390/cancers14225518.
    10.3390/cancers14225518
  4. Daniela M. Sousa; Neto E; Luís Leitão; José C. Mateus; Cecília J. Alves; Miguel Aroso; Ana C. Monteiro; et al. "Osteoclast-derived extracellular vesicles are implicated in sensory neurons sprouting through the activation of epidermal growth factor signaling". Cell & Bioscience 12 1 (2022): http://dx.doi.org/10.1186/s13578-022-00864-w.
    10.1186/s13578-022-00864-w
  5. Catarina Lourenço; Francisco Conceição; Carmen Jeronimo; Carmen Jerónimo; Meriem Lamghari; Daniela M. Sousa. "Stress in Metastatic Breast Cancer: To the Bone and Beyond". Cancers (2022): https://www.mdpi.com/2072-6694/14/8/1881.
    10.3390/cancers14081881
  6. Conceição, Francisco; Sousa, Daniela M.; Loessberg-Zahl, Joshua; Vollertsen, Anke R.; Neto, Estrela; Søe, Kent; Paredes, Joana; Leferink, Anne; Lamghari, Meriem. "A metastasis-on-a-chip approach to explore the sympathetic modulation of breast cancer bone metastasis". Materials Today Bio 13 (2022): 100219. http://dx.doi.org/10.1016/j.mtbio.2022.100219.
    10.1016/j.mtbio.2022.100219
  7. Mielan, Bartosz; Sousa, Daniela M.; Krok-Borkowicz, Malgorzata; Eloy, Pierre; Dupont, Christine; Lamghari, Meriem; Pamula, Elzbieta. "Polymeric Microspheres/Cells/Extracellular Matrix Constructs Produced by Auto-Assembly for Bone Modular Tissue Engineering". International Journal of Molecular Sciences 22 15 (2021): 7897. http://dx.doi.org/10.3390/ijms22157897.
    10.3390/ijms22157897
  8. Conceição, Francisco; Sousa, Daniela M.; Paredes, Joana; Lamghari, Meriem. "Sympathetic activity in breast cancer and metastasis: partners in crime". Bone Research 9 1 (2021): http://dx.doi.org/10.1038/s41413-021-00137-1.
    10.1038/s41413-021-00137-1
  9. Alves, C. J.; Couto, M.; Sousa, D. M.; Magalhães, A.; Neto, E.; Leitão, L.; Conceição, F.; et al. "Nociceptive mechanisms driving pain in a post-traumatic osteoarthritis mouse model". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-72227-9.
    10.1038/s41598-020-72227-9
  10. Couto, Marina; Vasconcelos, Daniela P.; Sousa, Daniela M.; Sousa, Beatriz; Conceição, Francisco; Neto, Estrela; Lamghari, Meriem; Alves, Cecília J.. "The Mechanisms Underlying the Biological Response to Wear Debris in Periprosthetic Inflammation". Frontiers in Materials 7 (2020): http://dx.doi.org/10.3389/fmats.2020.00274.
    10.3389/fmats.2020.00274
  11. Leitão, Luís; Neto, Estrela; Conceição, Francisco; Monteiro, Ana; Couto, Marina; Alves, Cecília J.; Sousa, Daniela M.; Lamghari, Meriem. "Osteoblasts are inherently programmed to repel sensory innervation". Bone Research 8 1 (2020): http://dx.doi.org/10.1038/s41413-020-0096-1.
    10.1038/s41413-020-0096-1
  12. Sousa, Daniela; Martins, Pedro S.; Leitão, Luís; Alves, Cecília J; Gomez-Lazaro, Maria; NETO, ESTRELA; Conceição, Francisco; Herzog, Herbert; Lamghari, Meriem. "The lack of neuropeptide Y-Y 1 receptor signaling modulates the chemical and mechanical properties of bone matrix". The FASEB Journal 34 3 (2020): 4163-4177. http://dx.doi.org/10.1096/fj.201902796r.
    Accepted • 10.1096/fj.201902796r
  13. Leite, D.M.; Sousa, D.M.; Lamghari, M.; Pêgo, A.P.. "Exploring Poly(Ethylene Glycol)-Poly(Trimethylene Carbonate) Nanoparticles as Carriers of Hydrophobic Drugs to Modulate Osteoblastic Activity". Journal of Pharmaceutical Sciences (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078853149&partnerID=MN8TOARS.
    10.1016/j.xphs.2020.01.007
  14. Sousa, D.M.; Martins, P.S.; Leitão, L.; Alves, C.J.; Gomez-Lazaro, M.; Neto, E.; Conceição, F.; Herzog, H.; Lamghari, M.. "The lack of neuropeptide Y-Y1 receptor signaling modulates the chemical and mechanical properties of bone matrix". FASEB Journal (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078663541&partnerID=MN8TOARS.
    10.1096/fj.201902796R
  15. Leitão, L.; Alves, C.J.; Alencastre, I.S.; Sousa, D.M.; Neto, E.; Conceição, F.; Leitão, C.; et al. "Bone marrow cell response after injury and during early stage of regeneration is independent of the tissue-of-injury in 2 injury models". FASEB Journal 33 1 (2019): 857-872. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059244844&partnerID=MN8TOARS.
    10.1096/fj.201800610RR
  16. Leitão, L.; Alves, C.J.; Sousa, D.M.; Neto, E.; Conceição, F.; Lamghari, M.. "The alliance between nerve fibers and stem cell populations in bone marrow: life partners in sickness and health". FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33 8 (2019): 8697-8710. http://www.scopus.com/inward/record.url?eid=2-s2.0-85070787227&partnerID=MN8TOARS.
    10.1096/fj.201900454R
  17. Costa, F.; Sousa, D.M.; Parreira, P.; Lamghari, M.; Gomes, P.; Martins, M.C.L.. "N-acetylcysteine-functionalized coating avoids bacterial adhesion and biofilm formation". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85037721926&partnerID=MN8TOARS.
    10.1038/s41598-017-17310-4
  18. Sousa, D.M.; Alencastre, I.S.; Leitão, L.; Neto, E.; Alves, C.J.; Lamghari, M.. "Therapeutic drugs in bone loss-associated disorders: Clinical outcom es and challenges". Current Drug Targets 18 6 (2017): 696-704. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019548793&partnerID=MN8TOARS.
    10.2174/1389450117666160709024547
  19. Neto, E.; Alves, C.J.; Leitão, L.; Sousa, D.M.; Alencastre, I.S.; Conceição, F.; Lamghari, M.. "Axonal outgrowth, neuropeptides expression and receptors tyrosine kinase phosphorylation in 3D organotypic cultures of adult dorsal root ganglia". PLoS ONE 12 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85025176517&partnerID=MN8TOARS.
    10.1371/journal.pone.0181612
  20. Alencastre, I.S.; Sousa, D.M.; Alves, C.J.; Leitão, L.; Neto, E.; Aguiar, P.; Lamghari, M.. "Delivery of pharmaceutics to bone: Nanotechnologies, high-throughput processing and in silico mathematical models". European Cells and Materials 31 (2016): 355-381. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973639341&partnerID=MN8TOARS.
    10.22203/eCM.v031a23
  21. Neto, E.; Leitão, L.; Sousa, D.M.; Alves, C.J.; Alencastre, I.S.; Aguiar, P.; Lamghari, M.. "Compartmentalized microfluidic platforms: The unrivaled breakthrough of in vitro tools for neurobiological research". Journal of Neuroscience 36 46 (2016): 11573-11584. http://www.scopus.com/inward/record.url?eid=2-s2.0-84996552043&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.1748-16.2016
  22. Alves, C.J.; Alencastre, I.S.; Neto, E.; Ribas, J.; Ferreira, S.; Vasconcelos, D.M.; Sousa, D.M.; Summavielle, T.; Lamghari, M.. "Bone injury and repair trigger central and peripheral NPY neuronal pathways". PLoS ONE 11 11 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84993996075&partnerID=MN8TOARS.
    10.1371/journal.pone.0165465
  23. Pinto, A.M.; Goncalves, C.; Sousa, D.M.; Ferreira, A.R.; Moreira, J.A.; Goncalves, I.C.; Magalhães, F.D.. "Smaller particle size and higher oxidation improves biocompatibility of graphene-based materials". Carbon 99 (2016): 318-329. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959449298&partnerID=MN8TOARS.
    10.1016/j.carbon.2015.11.076
  24. Sousa, D.M.; Conceição, F.; Silva, D.I.; Leitão, L.; Neto, E.; Alves, C.J.; Alencastre, I.S.; et al. "Ablation of Y1 receptor impairs osteoclast bone-resorbing activity". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84988625216&partnerID=MN8TOARS.
    10.1038/srep33470
  25. Alves, C.J.; Neto, E.; Sousa, D.M.; Leitão, L.; Vasconcelos, D.M.; Ribeiro-Silva, M.; Alencastre, I.S.; Lamghari, M.. "Fracture pain-Traveling unknown pathways". Bone 85 (2016): 107-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957799290&partnerID=MN8TOARS.
    10.1016/j.bone.2016.01.026
  26. Kapoor, S.; Semitela, Â.; Goel, A.; Xiang, Y.; Du, J.; Lourenço, A.H.; Sousa, D.M.; Granja, P.L.; Ferreira, J.M.F.. "Understanding the composition-structure-bioactivity relationships in diopside (CaO·MgO·2SiO2)-tricalcium phosphate (3CaO·P2O5) glass system". Acta Biomaterialia 15 (2015): 210-226. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922677729&partnerID=MN8TOARS.
    10.1016/j.actbio.2015.01.001
  27. Neto, E.; Alves, C.J.; Sousa, D.M.; Alencastre, I.S.; Lourenço, A.H.; Leitão, L.; Ryu, H.R.; et al. "Sensory neurons and osteoblasts: Close partners in a microfluidic platform". Integrative Biology (United Kingdom) 6 6 (2014): 586-595. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901624359&partnerID=MN8TOARS.
    10.1039/c4ib00035h
  28. Sousa, D.M.; McDonald, M.M.; Mikulec, K.; Peacock, L.; Herzog, H.; Lamghari, M.; Little, D.G.; Baldock, P.A.. "Neuropeptide y modulates fracture healing through Y1 receptor signaling". Journal of Orthopaedic Research 31 10 (2013): 1570-1578. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882886747&partnerID=MN8TOARS.
    10.1002/jor.22400
  29. Sousa, D.M.; Baldock, P.A.; Enriquez, R.F.; Zhang, L.; Sainsbury, A.; Lamghari, M.; Herzog, H.. "Neuropeptide Y Y1 receptor antagonism increases bone mass in mice". Bone 51 1 (2012): 8-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859915620&partnerID=MN8TOARS.
    10.1016/j.bone.2012.03.020
  30. Teixeira, L.; Sousa, D.M.; Nunes, A.F.; Sousa, M.M.; Herzog, H.; Lamghari, M.. "NPY revealed as a critical modulator of osteoblast function in vitro: New insights into the role of Y1 and Y2 receptors". Journal of Cellular Biochemistry 107 5 (2009): 908-916. http://www.scopus.com/inward/record.url?eid=2-s2.0-67749108153&partnerID=MN8TOARS.
    10.1002/jcb.22194
  31. Sousa, D.M.; Herzog, H.; Lamghari, M.. "NPY signalling pathway in bone homeostasis: Y1 receptor as a potential drug target". Current Drug Targets 10 1 (2009): 9-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-63049117952&partnerID=MN8TOARS.
    10.2174/138945009787122888
  32. Brás-Silva, C.; Monteiro-Sousa, D.; Duarte, A.J.; Guerra, M.; Fontes-Sousa, A.P.; Moura, C.; Areias, J.C.; Leite-Moreira, A.F.. "Nitric oxide and prostaglandins - Important players in endothelin-1 induced myocardial distensibility". Physiological Research 57 2 (2008): 165-174. http://www.scopus.com/inward/record.url?eid=2-s2.0-45849091552&partnerID=MN8TOARS.
  33. Fontes-Sousa, A.P.; Brás-Silva, C.; Pires, A.L.; Monteiro-Sousa, D.; Leite-Moreira, A.F.. "Urotensin II acutely increases myocardial length and distensibility: Potential implications for diastolic function and ventricular remodeling". Naunyn-Schmiedeberg's Archives of Pharmacology 376 1-2 (2007): 107-115. http://www.scopus.com/inward/record.url?eid=2-s2.0-38449119600&partnerID=MN8TOARS.
    10.1007/s00210-007-0180-8
  34. Ferreira-Martins, J.; Pires, A. L.; Ladeiras-Lopes, R.; Bras-Silva, C.; Monteiro-Sousa, D.; Castro-Chaves, P.; Leite-Moreira, A.. "Acute muscle stretch induces a time-dependent decrease in myocardial stiffness that is partially mediated by PKC activation". European Heart Journal 28 (2007): 426-426. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000208702202259&KeyUID=WOS:000208702202259.
  35. Bras-Silva, C.; Monteiro-Sousa, D.; Duarte, A.; Leite-Moreira, A.; Duarte, A. J.; Leite-Moreira, A. F.. "Functional evidence for the existence of ETA-ETB receptor crosstalk in the heart". Journal of Hypertension 25 (2007): S60-S60. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000248395100205&KeyUID=WOS:000248395100205.
  36. Ferreira-Martins, J.; Pires, A. Luisa; Ladeiras-Lopes, R.; Bras-Silva, C.; Monteiro-Sousa, D.; Castro-Chaves, P.; Leite-Moreira, A.. "Time dependent increase in myocardial distensibility after acute muscle stretch: The diastolic side of the Anrep effect". Journal of Hypertension 25 (2007): S310-S310. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000248395101378&KeyUID=WOS:000248395101378.
  37. Bras-Silva, C.; Monteiro-Sousa, D.; Duarte, A. J.; Lete-Moreira, A. F.. "Urocortin 2 as a novel neurohumoral modulator of diastolic function". European Heart Journal 28 (2007): 304-304. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000208702201429&KeyUID=WOS:000208702201429.
  38. Fontes-Sousa, A. P.; Bras-Silva, C.; Monteiro-Sousa, D.; Leite-Moreira, A. F.. "The novel role of urotensin II on the diastolic properties of myocardium". European Heart Journal 27 (2006): 846-846. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000240668406069&KeyUID=WOS:000240668406069.

Other

Other output
  1. Sensory neurons sprouting is dependent on osteoclast-derived extracellular vesicles involving the activation of epidermal growth factor receptors. 2018. Estrela Neto; Luís Leitão; José Mateus; Daniela M. Sousa; Francisco Conceição; Cecília J. Alves; Richard O. C. Oreffo; et al. https://doi.org/10.1101/259218.
    10.1101/259218
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/07/03 Vascularized and innervated bone deconstructed on a chip. , July 2-3, 2019, Austria. 2nd European Organ-on-Chip Conference (EUROoC 2019)
(Graz, Austria)
2019/05/27 Adhesion and growth of MC3T3 cells on surface-modified polymeric microspheres in different cell culture media TERMIS-EU 2019
(Rhodes, Greece)
2018/05/07 Bio-modeling breast cancer-bone metastases in microfluidic systems: a novel 3D approach 1º encontro 3CCB
(Porto, Portugal)
2017/06/19 Neurotrophic potential of Mesenchymal Stem Cells throughout osteoblast differentiation and under different ECM-like microenvironments Interrogation At The Biointerface, Advanced Summer School: The Research/ Clinic Interface At The Spine
(Porto, Portugal)
2017/06/19 Axonal outgrowth cues hidden in the osteoclasts secretome Interrogation At The Biointerface, Advanced Summer School: The Research/ Clinic Interface At The Spine
(Porto, Portugal)
2017/06/19 Bio-modeling breast cancer-bone metastases in microfluidic systems: a novel 3D approach Interrogation At The Biointerface, Advanced Summer School: The Research/ Clinic Interface At The Spine
(Porto, Portugal)
2016/10/27 Modelling breast cancer bone metastatic niche: an exploratory approach to study breast cancer-bone cells interactions 5th Symposium in Applied Bioimaging
(Porto, Portugal)
2016/06/23 In vivo bone marrow and cytokine dynamics in two experimentally injured tissues
(Davos, Switzerland)
2016/05/13 Neuropetide Y Y1 receptor deletion impairs matrix demineralization and resorption 43rd European Calcified Tissue Society Congress
(Rome, Italy)
2014/08/31 Improvement of graphene nanoplatelet biocompatibility by surface oxidation 26th European Conference on Biomaterials
(Liverpool, United Kingdom)
2014/06/10 Neuropeptide Y Y1 receptor antagonism: a novel anabolic tool for bone regeneration TERMIS EU
(Genova, Italy)
2014/05/17 The role of Neuropeptide Y Y1 receptor signalling in fracture healing 41st European Calcified Tissue Society Congress
(Prague, Czech Republic)
2011/10/19 Anabolic effects induced by oral administration of NPY Y1 receptor antagonist BIBO3304 in mice XXXI Congresso Nacional de Ortopedia e Traumatologia
(Estoril, Portugal)
2011/09/16 Neuropeptide Y receptor signaling in osteoblasts is required for normal glucose homeostasis in mice JBMR Annual Meeting
(San Diego, United States)
2007/06/16 Urocortin 2 acutely decreases myocardial stiffness XI Workshop of the ESH Young Investigator Initiative Group
(Milan, Italy)
2007/04/21 Efeitos Miocárdicos da Urocortina 2 XXVIII Congresso Português de Cardiologia
(Vilamoura, Portugal)
2007/01/24 Nitric oxide and prostaglandins – key downstream modulators of endothelin-1 induced increase in myocardial distensibility Winter Meeting on Translational Basic Science of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) - From Cardiac Adaptation to Failure and Back
(Garmisch-Partenkirchen, Germany)
2006/09/14 Urotensin II: a novel neurohumoral modulator of diastolic function The 16th ECVIM-CA (European College of Veterinary Internal Medicine- Companion Animal) Congress
(Amesterdan, Netherlands)
2006/09/02 NO and prostaglandins are required for the increase in myocardial distensibility induced by ET-1 XVth World Congress of Cardiology
(Barcelona, Spain)
2006/06/13 The novel role of urotensin II as a modulator of diastolic function Xth Workshop of the European Society of Hypertension Young Investigator Initiative Group
(Madrid, Spain)
2006/06/12 The increase in myocardial distensibility induced by ET-1 is dependent on NO and prostaglandins release Sixteenth European Meeting on Hypertension
(Madrid)
2006/04/22 Urotensina II: um novo modulador neurohumoral da função diastólica XXVII Congresso Português de Cardiologia
(Vilamoura, Portugal)
2006/04/22 O aumento da distensibilidade miocárdica induzido pela endotelina-1 depende da libertação endotelial de NO e prostaglandinas XXVII Congresso Português de Cardiologia
(Vilamoura, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/03/07 - Current Stress in Metastatic Breast Cancer
Supervisor
 Oncology (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2017 - Current Uncovering the role of beta-adrenergic signalling on breast cancer bone metastasis: a novel 3D biomodel
Co-supervisor of Francisco Conceição
 Bioengenharia (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020 - 2021 EXPLORING THE ROLE OF b2-ADRENERGIC SIGNALING PATHWAY IN BREAST CANCER BONE METASTASIS
Supervisor of Sofia Tojal Pinho
 Bioengenharia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
2020 - 2021 Sympathetic Innervation in Breast Cancer Bone Metastasis: Exploring the role of alpha2C-adrenergic signaling pathway in the bone metastatic niche
Supervisor of Ana Lúcia Fonseca
 Engenharia Biomédica (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2019/09 - 2020/11 The key role of periostin on bone metastatic niche and sensory neuron crosstalk
Co-supervisor of Beatriz Moura
 Bioengenharia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
2019 - 2019 ERASMUS - “Are gut hormones the key to combat osteoporosis?”
Co-supervisor of Jannika Oeke
 Master in Human Biology (Master)
Københavns Universitet, Denmark
2018 - 2018 ERASMUS - “Biological characteristics of polymeric PLGA microspheres for modular tissue engineering”
Co-supervisor of Bartosz Mielan
Akademia Górniczo-Hutnicza imienia Stanislawa Staszica w Krakowie, Poland
2017 - 2018 Identify the adrenergic signalling pathway(s) involved in breast cancer- induced bone metastasis
Supervisor of Catarina Martins Lourenço
 Oncologia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2016 - 2016 ERASMUS - "Drug delivery systems based on polymeric carriers to enhance bone tissue regeneration"
Co-supervisor of Liliana Joanna Szetlak
 Master degree in Biomedical Engineering (Master)
Akademia Górniczo-Hutnicza imienia Stanislawa Staszica w Krakowie, Poland
2016 - 2016 ERASMUS - "Drug delivery systems based on polymeric carriers to tune osteoclast behaviour".
Co-supervisor of Karolina Maria Strzebonska
 Master degree in Biomedical Engineering (Master)
Akademia Górniczo-Hutnicza imienia Stanislawa Staszica w Krakowie, Poland
2015 - 2016 Modelling breast cancer metastatic bone niche: a novel in vitro 3D microfluidic platform
Supervisor of Ana Rita Pereira
 Bioengenharia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
2014 - 2015 The role of Y1 receptor in osteoclastogenesis and bone resorption
Co-supervisor of Francisco Conceição
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017 - 2017 GLISTEN SYMPOSIUM The symposium provided a platform to share key advances and promote scientific collaboration, assembling leading experts to discuss the biology of GPCRs in physiological and pathological conditions. (2017/03/29 - 2017/03/31)
Symposium (Member of the Organising Committee)
 Instituto Nacional de Engenharia Biomédica, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/07/12 A Bottom-Up Approach to Model Tumor-Vascular Interactions
(Thesis) Main arguer
 Inês Oliveira Pereira Coutinho (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/07/28 Multifunctional Cell-Instructive Pectin Hydrogels for Wound Healing Applications
(Thesis) Main arguer
 Eduardo Filipe Mendes Capitão (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/06/19 Impacto da infeção por Mycobacterium avium na biologia do osso
(Thesis) Main arguer
 Tiago João Carvalho Oliveira (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2023 - Current Biomaterials Science Royal Society of Chemistry
2022 - Current Cancers MDPI
2018 - Current Neuropeptides Elsevier
2015 - Current PloS One Public Library of Science
2015 - Current Journal of the American Board of Family Medicine American Board of Family Medicine

Association member

Society Organization name Role
2011 - Current European Calcified Tissue Society (ECTS)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021 - Current Invited Lecturer: "ADVANCED CELL CULTURE TECHNOLOGIES: innovative approaches to study the interactions between the bone and the peripheral nervous system" Mestrado Escola Universitária Vasco da Gama Centro Investigação Vasco da Gama, Portugal
2017 - Current Lecturing “Bio-Imaging Technologies to Study Host-Biomaterial Interface” as part of the “Biological Responses To Biomaterials” classes Bioengenharia (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 - 2018 Invited speaker in the module “New Therapies and Technologies” of the GABBA Doctoral Program (Doutoramento) Universidade do Porto, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2019 - 2022 5th PhDay Evaluation panel (abstracts, oral and poster)
Evaluator
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Other jury / evaluation

Activity description Institution / Organization
2019/07/11 - Current Comissão de Acompanhamento: PhD Thesis - Ana Margarida da Silva Teixeira Title: “Biodegradable scaffolds for the regeneration of breast tissue” Biomedical Engineering Doctoral Program Universidade do Porto Faculdade de Engenharia, Portugal
Distinctions

Award

2016 Bioimaging 2016 Grant
i3S/INEB, Portugal
2015 ECTS-IBMS Travel Award
European Calcified Tissue Society, United Kingdom
2014 ECTS New Investigator Award (in recognition of outstanding work)
European Calcified Tissue Society, United Kingdom
2012 Best Poster “Regeneration, Bio-imaging and signals”
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Other distinction

2017 Post-Doctoral Fellowship (SFRH/BPD/115341/2016)
2007 PhD Fellowship (SFRH/BD/37654/2007)
2006 Professional Internship Program Scholarship
Universidade de Aveiro, Portugal