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PhD in Pharmacy with emphasis in Toxicology, with a thesis entitled “Thioredoxin Reductase Inhibitors in anticancer therapy: Thimerosal Efficacy in Glioblastoma”. Researcher Fellow at NANOPLASTOX, a project that elucidates the mechanisms underlying an inflammatory response of intestinal cells to nanoplastics and the link to genotoxicity and evaluates the interaction of nanoplastics with environmental carcinogens. Researcher Fellow at the "PAHMIX - Mixtures of Environmental Carcinogens: a molecular approach to improve environmental risk assessment strategies" project at Faculty of Sciences and Technology - University Nova of Lisbon. Participated at the project Target_Cancer at the Toxicology laboratory at the Faculty of Pharmacy of University of Lisbon. Masters in Pharmaceutical Sciences at the State University of Western Paraná - Unioeste (Brazil) , with emphasis in Cellular Toxicology Research, diploma recognized by a Portuguese institution. Former integrant at the Cellular Toxicity Mechanisms Group of Research at Unioeste. Pharmacist graduated at the Pharmacy Course of State University of Western Paraná - Unioeste (Brazil), with diploma recognized by a Portuguese institution . During graduation developed activities in Basic Chemistry, Parasitology and Clinical Toxicology. Good command of laboratory techniques, Cell culture, Cell viability assays, Biomolecular techniques (Protein determination, Western blot, protein activity, protein expression, RT-PCR). Experience working with Atomic Absorption Spectroscopy - mainly graphite furnace. Experience working and manipulating animals, rats and mices (Course habilitation acquired in Brazil).
Identification

Personal identification

Full name
Isabella Calvo Bramatti

Citation names

  • Bramatti, Isabella

Author identifiers

Ciência ID
D41D-0E82-B973

Telephones

Mobile phone
  • 932538684 (Personal)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Basic Medicine - Toxicology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Italian Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2019/01 - 2024/03
Concluded
Farmácia (Doutoramento)
Major in Toxicologia
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Thioredoxin Reductase Inhibitors in anticancer therapy: Thimerosal Efficacy in Glioblastoma" (THESIS/DISSERTATION)
2015/03/02 - 2017/02/06
Concluded
Mestrado em Ciências Farmacêuticas (Master)
Major in Toxicologia
Universidade Estadual do Oeste do Paraná, Brazil
"Effect of the coadministration of quercetin with tamoxifen at the antioxidant and cholinergic activity in hippocampus of ovariectomized rats" (THESIS/DISSERTATION)
17
2010/02/01 - 2014/12/13
Concluded
Farmácia (Bachelor)
Universidade Estadual do Oeste do Paraná, Brazil
"Effects of quercetin on cardiovascular risk of ovariectomized rats treated with tamoxifen" (THESIS/DISSERTATION)
14
Affiliation

Science

Category
Host institution
Employer
2023/01 - 2023/12 Research Assistant (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/01/01 - 2022/12/30 Researcher (Research) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/06 - 2020/02 Contracted Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/05 - 2017/02 Researcher (Research) Universidade Estadual do Oeste do Paraná, Brazil
Universidade Estadual do Oeste do Paraná, Brazil
2011/03 - 2012/03 Research Trainee (Research) Universidade Estadual do Oeste do Paraná, Brazil
Universidade Estadual do Oeste do Paraná, Brazil

Others

Category
Host institution
Employer
2016/02 - 2016/12 Internship in Teaching at the Pharmacy Course Universidade Estadual do Oeste do Paraná, Brazil
2014/09 - 2015/12 Internship at an Oncologic Hospitalar Pharmacy Hospital do Câncer de Cascavel UOPPECAN, Brazil
2014/06 - 2014/08 Internship at an Oncologic Hospitalar Pharmacy Hospital Erasto Gaertner, Brazil
Projects

Grant

Designation Funders
2023/04/17 - Current Nanoplastic Toxicity: from gut inflammation to systemic effects
2022.04884.PTDC
Research Fellow
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - Current PAHMIX - Mixtures of Environmental Carcinogens: a molecular approach to improve environmental risk assessment strategies
PTDC/CTA-AMB/29173/2017
Research Fellow
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Ongoing
2018/11 - Current Target_Cancer
PTDC/MED-FAR/31136/2017
Researcher
Concluded

Other

Designation Funders
2013 - Current Intestinal parasites control at students of a state school in Cascavel - PR - Brazil
no number
Integration into Research Grant Fellow
2015 - 2017 Evaluation of the influence of butyrylcholinesterase upon the cardiovascular risk factors at ovariectomized rats treated with tamoxifen
no number
Concluded
2011 - 2012 Identification of drug interaction between fluoxetine and drugs with action at the Central Nervous System.
no number
Integration into Research Grant Fellow
Concluded
Outputs

Publications

Book chapter
  1. Bringhentti, Elouisa; Silva, Fernanda Coleraus; Bramatti, Isabella Calvo; Marek, Carla Brugin; Itinose, Ana Maria. "EFEITO DA COADMINISTRAÇÃO DE TAMOXIFENO E QUERCETINA SOBRE A LIPOPEROXIDAÇÃO EM FIGADOS DE RATOS DA LINHAGEM WISTAR: ESTUDOS IN VIVO E IN VITRO". In Sustentabilidade em Ciência e Tecnologia de Alimentos, 87-98. Brazil: Atena Editora, 2020.
    Published • 10.22533/at.ed.8412003069
Conference abstract
  1. Monteiro, Vânia; Bramatti, Isabella; Amaro, Filipa; Guedes de Pinho, Paula; Figueiredo, Neusa; Dias da Silva, Diana; Martins, Marta; Pinto, Joana. "Impact of benzo[a]pyrene, phenanthrene, and their mixtures on the metabolome of hepatocytes isolated from fish". Paper presented in APCF-TOXRUN International Congress. RevSALUS - Revista Científica Internacional da Rede Académica Das Ciências Da Saúde da Lusofonia, 2022.
    Published • 10.51126/revsalus.v4iSup.246
Conference poster
  1. Bramatti, Isabella; Antunes, Joana; Martins, Marta; Branco, Vasco. "Interaction of nanoplastics with intestinal epithelia: effect on permeability.". Paper presented in Eurotox 2023, 2023.
  2. Bramatti, Isabella; Branco, Vasco; Carvalho, Cristina. "Effect of ethylmercury-containing thimerosal over hypoxia-related factors in glioblastoma cells". Paper presented in XVI International Congress of Toxicology, 2022.
  3. Monteiro, Vânia; Bramatti, Isabella; Amaro, Filipa; Guedes de Pinho, Paula; Figueiredo, Neusa; Dias da Silva, Diana; Martins, Marta; Pinto, Joana. "Metabolic alterations induced by polycyclic aromatic hydrocarbons on the endometabolome of fish primary hepatocytes". Paper presented in Metabolomics 2022, 2022.
  4. Matos, Beatriz; Bramatti, Isabella; Diniz, Mário; Branco, Vasco; Marta Martins. Corresponding author: Matos, Beatriz. "Cytotoxic effects of PAHs mixtures in immortalized cells of Zebrafish (Danio rerio)". Paper presented in SETAC EUROPE 32nd ANNUAL MEETING 2022, 2022.
  5. Bramatti, Isabella; Figueiredo, Neusa; Matos, Beatriz; Marta Martins. "Interaction mechanisms of polycyclic aromatic hydrocarbons in fish primary hepatocyte cells: from molecular to genotoxic effects". Paper presented in CICTA 2021 - Blumenau, 2021.
  6. Branco, Vasco; Bramatti, Isabella. "Interaction mechanisms of Polycyclic Aromatic Hydrocarbons in fish primary hepatocyte cell: from molecular to genotoxic toxic effects". Paper presented in 9th Ibero-American Congress on Contamination and Environmental Toxicology, 2021.
  7. Bramatti, Isabella; Branco, Vasco; Carvalho, Cristina. "Effect of thimerosal over hypoxia-related factors in glioblastoma cells". Paper presented in EUROTOX 2021, 2021.
Journal article
  1. Bramatti, Isabella; Aschner, Michael; Branco, Vasco; Carvalho, Cristina. "Exposure of human glioblastoma cells to thimerosal inhibits the thioredoxin system and decreases tumor growth-related factors". Toxicology and Applied Pharmacology 484 (2024): 116844. http://dx.doi.org/10.1016/j.taap.2024.116844.
    10.1016/j.taap.2024.116844
  2. Bramatti, Isabella; Matos, Beatriz; Figueiredo, Neusa; Pousão-Ferreira, Pedro; Branco, Vasco; Martins, Marta. "Interaction of Polycyclic Aromatic Hydrocarbon compounds in fish primary hepatocytes: From molecular mechanisms to genotoxic effects". Science of The Total Environment (2022): 158783. http://dx.doi.org/10.1016/j.scitotenv.2022.158783.
    Published • 10.1016/j.scitotenv.2022.158783
  3. Pires, Vanessa; Bramatti, Isabella; Aschner, Michael; Branco, Vasco; Carvalho, Cristina. "Thioredoxin Reductase Inhibitors as Potential Antitumors: Mercury Compounds Efficacy in Glioma Cells". Frontiers in Molecular Biosciences 9 (2022): http://dx.doi.org/10.3389/fmolb.2022.889971.
    Published • 10.3389/fmolb.2022.889971
  4. Silva, Fernanda Coleraus; Bramatti, Isabella Calvo; Toledo, Adrieli Gorlin; Salles, Fernando Marques; Itinose, Ana Maria; Marek, Carla Brugin. "Antihyperglycemic Effect of Quercetin in Ovariectomized Rats Treated with Tamoxifen". Journal of Medicinal Food 20 3 (2017): 235-242. http://dx.doi.org/10.1089/jmf.2016.0078.
    Published • 10.1089/jmf.2016.0078
  5. Bramatti, I.C.; Marek, C.B.; Itinose, A.M.; Silva, F.C.. "Effects of quercetin on cardiovascular risk of ovariectomized rats treated with tamoxifen". Toxicology Letters 259 (2016): S134-S135. http://dx.doi.org/10.1016/j.toxlet.2016.07.345.
    Published • 10.1016/j.toxlet.2016.07.345
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/12/02 Interaction mechanisms of Polycyclic Aromatic Hydrocarbons in fish primary hepatocyte cell: from molecular to genotoxic effects CICTA 2021
(Brazil)
2019/02/07 THIOREDOXIN REDUCTASE INHIBITORS AS A POTENTIAL ANTITUMORAL: MERCURY COMPOUNDS EFFICACY IN TWO DIFERENTE GLIOMA CELLS XLIX REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA/ XXXVII REUNIÃO FARMACOLOGIA CLÍNICA/ XVIII REUNIÃO TOXICOLOGIA
Faculdade de Farmácia Universidade do Porto (Porto, Portugal)
2019 REPURPOSING THIMEROSAL TO TARGET GLIOBLASTOMA CELLS: COMPARISON TO TEMOZOLOMIDE 11th iMed.ULisboa Postgraduate Students Meeting & 4rd i3DU Meeting
Universidade de Lisboa (Lisboa, Portugal)
2016 Effects of quercetin on cardiovascular risk of ovariectomized rats treated with tamoxifen XIV International Congress of Toxicology and X Mexican Congress of Toxicology
(Mérida, Mexico)
2016 In vitro effect of quercetin at the acetylcholinesterase activity 4ta. Reunión Internacional de Ciencias Farmacéuticas
(Rosário, Argentina)
2016 In vitro effect of quercetin and tamoxifen at butyrylcholinesterase activity 6° Congresso de Ciências Farmacêuticas do Mercosul
(Cascavel, Brazil)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2013 - 2013 Participação em Congresso
Congress
5° COSIMP - Congresso de Ciências Farmacêuticas do Mercosul
Universidade Estadual do Oeste do Paraná, Brazil
2012 - 2012 Participação em Congresso
Congress
16° FARMAPOLIS
Universidade Federal de Santa Catarina, Brazil
2011 - 2011 Participação de Congresso
Congress
8th International Confress of Pharmaceutical Sciences - CIFARP
Universidade de São Paulo Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Brazil
2011 - 2011 Jornada Acadêmica 4° JOFARMA-Jornada Acadêmica da Farmácia da UNIOESTE
Universidade Estadual do Oeste do Paraná, Brazil
2011 - 2011 Participação em Congresso
Congress
4° COSIMP - Congresso de Ciências Farmacêuticas do Mercosul
Universidade Estadual do Oeste do Paraná, Brazil
2010 - 2010 Campanha Nacional pelo Uso Racional de Medicamentos

Committee member

Activity description
Role
Institution / Organization
2016 - 2016 Membro de Comissão do 6° Congresso de Ciências Farmacêuticas do Mercosul
Member
Universidade Estadual do Oeste do Paraná, Brazil

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/04/06 - 2021/04/26 Curso Comunicar Ciência Clara II
2012 - 2012 Curso em Congresso Análise de Casos Clínicos em Citopatologia Universidade Federal de Santa Catarina, Brazil
2011 - 2011 Curso de Perícias Forenses
2010/05/01 - 2010/05/01 Curso de Análise Forense de DNA

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2016 - 2016 Participação em banca de tese de conclusão de curso
Member
Distinctions

Award

2016 International Congress of Toxicology - ICT XIV Junior Fellowship
International Union of Toxicology, United States

Title

2017 TOEFL iBt