Identification
Personal identification
- Full name
- Diana Filipa Ferreira da Silva
Citation names
- Silva, Diana
- Silva DF
Author identifiers
- Ciência ID
- D514-41E7-3DF1
- Google Scholar ID
- https://scholar.google.com/citations?user=Fc0lqlsAAAAJ&hl=en
Knowledge fields
- Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
- Medical and Health Sciences - Basic Medicine - Neurosciences
- Natural sciences - Biological Sciences - Cell Biology
- Medical and Health Sciences - Basic Medicine - Physiology
Languages
Language | Speaking | Reading | Writing | Listening | Peer-review |
---|---|---|---|---|---|
English | Proficiency (C2) | Proficiency (C2) | Proficiency (C2) | Proficiency (C2) | Proficiency (C2) |
French | Intermediate (B1) | Upper intermediate (B2) | Intermediate (B1) | Elementary (A2) | Elementary (A2) |
Education
Degree | Classification | |
---|---|---|
2019/11/04 - 2019/11/15
Concluded
|
Modular Training in Laboratory Animal Science (Diploma de especialização)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Approved |
2015/04 - 2019/01
Concluded
|
The effect of bacterial Pathogen-Associated Molecular Patterns on Parkinson´s disease-like pathology hallmarks (Pós-doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
|
2014
Concluded
|
Doutoramento em Biociências (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Mitochondrial signaling pathway in Alzheimer´s disease: disclosure of new therapeutic targets" (THESIS/DISSERTATION)
|
Aprovado com distinção e louvor por unanimidade |
2008/09/01 - 2010/07/13
Concluded
|
Mestrado em Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Mitochondrial dysfunction mediated autophagy: relevance to Alzheimer´s disease" (THESIS/DISSERTATION)
|
18 |
2008
Concluded
|
Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
|
15 |
Affiliation
Science
Category Host institution |
Employer | |
---|---|---|
2019/02/01 - Current | Contracted Researcher (Research) | Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
2015/04/01 - 2019/01/31 | Postdoc (Research) | Fundação para a Ciência e a Tecnologia, Portugal |
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal | ||
2015/08/01 - 2016/07/31 | Visiting Researcher (Research) | Katholieke Universiteit Leuven, Belgium |
VIB KU Leuven Center for Brain & Disease Research, Belgium |
Others
Category Host institution |
Employer | |
---|---|---|
2010/09/01 - 2014/12/15 | PhD student with a FCT fellowship (SFRH/BD/62644/2011). | Fundação para a Ciência e a Tecnologia, Portugal |
2011/11/01 - 2012/06/15 | PhD visiting student at Research Institute de Kansas City, USA | University of Kansas School of Medicine, United States |
2009/09/01 - 2010/07/13 | Intership/Master thesis development with final classification of 19/20. | Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
Projects
Grant
Designation | Funders | |
---|---|---|
2024/09 - Current | Modulation of primary cilia as a new strategy to mitigate aging.
2023.09788.CBM
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2022/01/01 - 2022/08/14 | Microbiome-miRNAs axis in Parkinson´s disease: involvement of mitochondial mediated inflammatory response
EXPL/MED-NEU/1515/2021
Researcher
Universidade de Coimbra, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2021 - 2022 | The Gut-Brain-Immune system axis in Parkinson´s disease.
PTDC/MED-NEU/3644/2020
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2019 - 2021 | The role of quality control mechanisms in the loss of proteostasis in age-dependent neurodegenerative disorders
PTDC/MED-NEU/30712/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2018 - 2021 | The ups and downs of cellular stress: the "MAM hypothesis" for Bipolar disorder pathophysiology.
PTDC/MED-NEU/28214/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2017 - 2020 | The toxinogenic gut microbiome in sporadic Parkinson´s Disease: a quest for new antiPDbiotics.
Prémio Santa Casa Mantero Belard 2016
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Santa Casa da Misericórdia de Lisboa
Ongoing
|
2014 - 2014 | Validate tau acetylation as an AD biomarker.
Project GAI
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Universidade de Coimbra Faculdade de Medicina
Concluded
|
2010 - 2012 | Mitochondrial-dependent impairment of intracellular trafficking in Parkinson´s disease
PTDC/SAU-NEU/102710/2008
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2010 - 2011 | Early Diagnosis of Alzheimer’s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools
PIC/IC/83206/2007
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Centro Hospitalar e Universitário de Coimbra EPE, Portugal |
Fundação para a Ciência e a Tecnologia
Concluded
|
Outputs
Publications
Book chapter |
|
Conference poster |
|
Journal article |
|
Thesis / Dissertation |
|
Other
Other output |
|
Activities
Oral presentation
Presentation title | Event name Host (Event location) |
|
---|---|---|
2021/06/10 | Bacterial endotoxin-mediated innate immunity activation through mitochondrial dysfunction in Parkinson´s disease | 55th Annual Scientific Meeting (online event)
European Society for Clinical Investigation (Spain)
|
2019/05 | The gut hypothesis for Alzheimer´s disease: bacterial metabolites cause bioenergetic failure and activation of innate immunity in cortical neurons. | 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Coimbra, Portugal)
|
2014/09 | Bridging Tau and Amyloid-ß pathologies in sporadic Alzheimer´s disease: mitochondria under the spotlight | 2nd International Conference on Alzheimer´s Disease and Dementia
OMICS group (Valencia , Spain)
|
2014/06 | Mitochondria: the unifying entity from amyloid-ß and Tau pathology to neurodegeneration in sporadic Alzheimer´s disease | EuroMit 2014- International Meeting on Mitochondrial Pathology
EuroMit (Tampere, Finland)
|
2013/12 | Mitochondria in the road to neurodegeneration in sporadic Alzheimer´s disease. | XI Annual CNC Meeting
Center for Neuroscience and Cell Biology (Cantanhede, Portugal)
|
2013/05/30 | Mitochondrial dysfunction-dependent microtubule depolarization drives autophagic-lysosomal pathway impairment in MCI and AD cybrids | XIII Reunião da Sociedade Portuguesa de Neurociências
Sociedade Portuguesa de Neurociências (Luso, Portugal)
|
2011/06 | Mitochondrial function and oxidative stress markers in Mild Cognitive Impairment cybrids containing an NT2 neuron-like nuclear background. | 25ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência
Grupo de Estudos de Envelhecimento Cerebral e Demência (Tomar, Portugal)
|
2010/06/25 | Mitochondrial dysfunction-mediated autophagy: relevance to Alzheimer´s disease | 24ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência, 25-26 June, Tomar, Portugal
Grupo de Estudos de Envelhecimento Cerebral e Demência (Tomar, Portugal)
|
Supervision
Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
---|---|---|
2019/09 - 2020/11/13 | Mitochondrial impact in innate immunity activation in Parkinson’s disease
Co-supervisor of Diogo Cardetas Banha
|
Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
|
Event organisation
Event name Type of event (Role) |
Institution / Organization | |
---|---|---|
2018/03/23 - 2018/03/23 | Defining a career plan is a challenging task for young scientists. In the last years, investment by the Government has allowed
Life Science and Biomedicine students to pursue a PhD in Portugal, but after graduation many face a future of uncertainty.
The symposium Overcoming Challenges in Scientific Careers, the Biomedical Research Post-Doctoral Forum@UC aimed to create
an opportunity for PhD holders and PhD students to reflect on their career paths and make informed choices, by contacting
and hearing from people of diverse scientific backgrounds (2018/03/23)
Symposium (Member of the Organising Committee)
|
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
Jury of academic degree
Topic Role |
Candidate name (Type of degree) Institution / Organization |
|
---|---|---|
2021/06/25 | c-Src/Fyn- mediated mitochondrial dysfunction in Huntington’s Disease
(Thesis) Main arguer
|
Joana Fernandes dos Santos (Other)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
|
Ad Hoc journal article review
Journal title (ISSN) | Publisher | |
---|---|---|
2019 - Current | International Journal of Molecular Sciences | MDPI |
2019 - Current | Frontiers in Aging Neuroscience | Frontiers |
2018 - Current | Biomedicine & Pharmacotherapy | Elsevier |
2017 - Current | Journal of Alzheimer´s disease | IOS Press |
Committee member
Activity description Role |
Institution / Organization | |
---|---|---|
2023/06 - 2026 | Member of the PhD committee/external advisor of Inês Moniz during the completion of her PhD in Experimental Biology and Biomedicine
(BEB). These committe meets once a year for follow up advisory.
Member
|
Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
Course / Discipline taught
Academic session | Degree Subject (Type) | Institution / Organization | |
---|---|---|---|
2023/11/18 - Current | Primary cilia and their relevance in disease mechanisms | Master in Pharmaceutical Biotechnology (Mestrado) | Universidade de Coimbra Faculdade de Farmácia, Portugal |
2021/03/19 - 2022 | Mitochondria and Aging. Basic notions of what is aging; the role of mitochondria in controling Aging process; mitochodrial function; mitochondrial DNA; Aging associated diseases - Alzheimer´s and Parkinson´s disease; mitochondrial-dependent activation of innate immunity. | Biologia do Envelhecimento (Mestrado integrado) | Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal |
2017/02/23 - 2022 | Investigação Aplicada | Mestrado Integrado em Medicina (Mestrado integrado) | Universidade de Coimbra Faculdade de Medicina, Portugal |
2015/04 - 2020/02 | Oxidative stress, free radicals and e aging process. Oxidative stress – concepto; free radicals; oxidative species and reactive oxygen species (ROS) – basic notions. Sources of oxidants: mitochondria and phagocytes. Physiological relevance of oxidation: the role of ROS in signaling pathways. Oxidative damage of Biomolecules by ROS. Mechanisms of defense against ROS: enzymatic systems and physiological antioxidants. Evidence of oxidative stress in normal aging: alterations of redox state with aging; lesions accumulation. | Ciências de Engenharia Biomédica (Mestrado integrado) | Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal |
Journal scientific committee
Journal title (ISSN) | Publisher | |
---|---|---|
2021 - 2022 | Antioxidants | MDPI |
Mentoring / Tutoring
Topic | Student name | |
---|---|---|
2023/02/06 - 2023/05/18 | Primary cilia modulation as a new strategy to mitigate aging phenotype of progeria experimental models | Francisco Costa |
2022/03/07 - 2022/03/25 | MITOCHONDRIAL REGULATION OF INNATE IMMUNITY ACTIVATION IN SPORADIC PARKINSON’S DISEASE | Laura Nóbrega |
2019/09 - 2020/11 | MITOCHONDRIAL IMPACT IN INNATE IMMUNITY ACTIVATION IN SPORADIC PARKINSON’S DISEASE | Diogo Cardetas Banha |
2017/03 - 2017/06 | Bacteria metabolites impairment of mitochondrial function in cortical primary neurons | Francisco Mano |
2014/09 - 2015/07 | Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's disease pathology. | Rui Gomes |
2015/05 - 2015/06 | Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology. | Luís Gomes |
2014/04 - 2014/05 | Sirtuin 2 activation modulated by mitochondrial dysfunction | Alberto Soares |
2014/01 - 2014/04 | Mitochondrial dysfunction and autophagy regulation in Alzheimer´s disease | Júlia Reis |
2009/09 - 2010/07 | NAP effect in Alzheimer´s disease rat model | Diana Raposo |
Distinctions
Other distinction
2014 | Best presentation award. |
2013 | Travel grant from Seahorse Biosciences
Seahorse Biosciences , Portugal
|
2011 | FEBS Youth Travel Fund (YTF) grant |