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Raquel A Oliveira is an Associate Professor at Católica Medical School, Universidade Católica Portuguesa and vice-director of the Católica Biomedical Research Centre. Her research group aims to understand how mitotic chromosomes are assembled, how their structure impacts processes involving the DNA molecule (e.g. transcription), and how failures in these processes perturb mitotic fidelity, cell physiology and organism development. Raquel Oliveira's interest in Chromosome biology started during her PhD studies at IBMC-Univ. Porto (2007), under the supervision of Prof. Claudio E. Sunkel. She completed her PhD in 2007, awarded by Universidade de Coimbra Faculdade de Ciencias e Tecnologia, and previously a Licenciatura in Bioquimica - Especialização em Bioquímica Aplicada in 2002 by Universidade do Porto Faculdade de Ciências. She published over 30 publications in highly prestigious international journals (e.g. Nat Cell Biol, Science Advances, Plos Biology, Current Biology, Cell Reports, eLife). She holds over 1000 citations, with an average of 53 citations per publication (Google Scholar, research papers only). Since starting her independent group (2012), Raquel Oliveira has participated in several international and national conferences (2 as keynote speaker, 17 as an invited speaker /6 selected oral communications). She also (co)organised several highly prestigious international conferences (3 EMBO workshops, 1 EMBO Young Scientists Forum and 2 JEDI meetings), further underscoring her position as a leader in the field. Over her academic career, she consolidated a vast network of scientific acquaintances, including several past and present collaborations, numerous researchers she hosted at the IGC, and several invited seminars at various national and international institutes. She routinely reviews papers for the most prestigious journal in the field and participated as a panel member or external evaluator for various grant agencies. Raquel Oliveira also continuously teaches graduate courses: our in-house programme (Integrative Biology and Biomedicine); PGCD, a program dedicated to Portuguese-speaking African students 8http://www.igc.gulbenkian.pt/education/pgcd) and at the EMBO YIP PhD Course. Since 2012, Raquel Oliveira has attracted talented people to her team, acquired considerable supervision skills (5 PhD and 3 MSc degrees completed) and secured highly competitive funding (~4MEUR), including an ERC Starting Grant, an ERC Consolidator Grant, an EMBO Installation Grant and a Marie Curie Career Integration Grant. She was elected an EMBO member in 2022. CAREER BREAKS Raquel Oliveira was on maternity leave from October 2018-February 2019, followed by a reduced working-hours schedule until October 2019.
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Identification

Personal identification

Full name
Raquel Aguiar Cardoso de Oliveira

Citation names

  • Oliveira, Raquel A

Author identifiers

Ciência ID
D51E-6355-683E
ORCID iD
0000-0002-8293-8603
Google Scholar ID
0-I0UeQAAAAJ&hl
Researcher Id
F-4405-2012

Email addresses

  • raaoliveira@ucp.pt (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2007
Concluded
 Doutoramento em Bioquímica, especialidade de Biologia Molecular (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Condensins and mitotic chromosome structure: functional and dynamic analysis in Drosophila melanogaster" (THESIS/DISSERTATION)
 Aprovada com distinção e louvor
2002
Concluded
 Bioquimica - Especialização em Bioquímica Aplicada (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Barley 14-3-3 interacting proteins purified by affinity chromatography" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2022/09 - Current Principal Investigator (Research) Universidade Católica Portuguesa, Portugal
Universidade Católica Portuguesa - Católica Biomedical Research Centre, Portugal
2012/06/01 - Current Principal Investigator (Research) Instituto Gulbenkian de Ciência, Portugal
2007/02/01 - 2012/05/31 Postdoc (Research) University of Oxford, United Kingdom
University of Oxford, United Kingdom
2003/03/01 - 2007/01/31 Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2005/10/04 - 2006/06/30 Visiting Researcher (Research) Universität Bayreuth, Germany
Universität Bayreuth, Germany

Teaching in Higher Education

Category
Host institution 		Employer
2022/09 - Current Associate Professor (University Teacher) Universidade Católica Portuguesa, Portugal
Projects

Grant

Designation Funders
2023/01 - 2026/12 CohesiNet - Cohesin and its regulators: from chromosome dynamics and nuclear architecture to human diseases
CohesiNet - GA101072505
Supervisor
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions, Belgium
Ongoing
2021/10/01 - 2026/09/30 Chromosome-based mechanisms of transcriptional inactivation during mitosis
101002391 - ChromoSilence
ERC-2020-COG-101002391 - ChromoSilence
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 European Research Council
Ongoing
2023/03/01 - 2026/02/28 Controlo do tráfico de proteínas em fisiologia e patologia vascular
2022.09228.PTDC
Researcher
Universidade Católica Portuguesa, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/01/01 - 2025/12/31 Novel mitotic DNA topology regulators
2022.01782.PTDC
10.54499/2022.01782.PTDC
Principal investigator
Universidade Católica Portuguesa, Portugal

Instituto Gulbenkian de Ciência, Portugal

Universidade do Algarve, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/01 - 2024/08/31 Estudo do BUB1 em neurodesenvolvimento: identificação de novas funções
10.54499/2022.01028.PTDC
Consultant
Fundação para a Ciência e a Tecnologia
Ongoing
2018/09/29 - 2021/09/28 O despertar do oócito: reactivação transcricional após um estado quiescente prolongado.
PTDC/BIA-BID/28441/2017
Researcher
Universidade do Algarve, Portugal

Universidade do Porto, Portugal

Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2015/10 - 2021/09 Chromosome Architecture and the Fidelity of Mitosis during Development
ERC-2014-STG-638917
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 European Research Council
Concluded
2018 - 2021 Function and regulation of mitotic bookmarking by RBPJ/Notch during vertebrate neurogenesis
PTDC/BIA-BID/29663/2017
Co-Principal Investigator (Co-PI)
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2014/01/01 - 2019/12/31 The active chromosome: the role of chromosome structure in the fidelity of mitosis
IG2778
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 European Molecular Biology Organization (EMBO)
Concluded
2013/07/01 - 2016/12/31 Imaging the structure and dynamics of molecules and complexes in living organisms
RECI/BEX-BCM/0083/2012
Researcher
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Fundação Calouste Gulbenkian, Portugal

Instituto Gulbenkian de Ciência, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/01/01 - 2016/12 Chromosome Condensation and Cohesion
info:eu-repo/grantAgreement/EC/FP7/321883/EU
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 European Commission
Concluded

Contract

Designation Funders
2018/10/01 - 2022/08/31 Mitotic chromosome architecture and the fidelity of mitosis during development
CEECIND/01092/2017
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/10/01 - 2018/09/30 Chromosome Dynamics during mitosis
IF/00851/2012/CP0185/CT0004
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Oliveira, Raquel. "Microinjection Techniques in Fly Embryos to Study the Function and Dynamics of SMC Complexes". 2019.
    10.1007/978-1-4939-9520-2_19
  2. Mirkovic, Mihailo; Oliveira, Raquel A.. Corresponding author: Oliveira, Raquel A.. "Centromeric Cohesin: Molecular Glue and Much More". In Progress in Molecular and Subcellular Biology, 485-513. Springer International Publishing, 2017.
    Published • 10.1007/978-3-319-58592-5_20
  3. "Cromatina e cromossomas (Capítulo 8)". In Biologia Molecular e Celular, 139-165. Portugal: Lidel - Edições Técnicas, 2012.
    Published
Journal article
  1. Catarina Carmo; João Coelho; Rui D Silva; Alexandra Tavares; Ana Boavida; Paola Gaetani; Leonardo G Guilgur; Rui Gonçalo Martinho; Raquel A Oliveira. "A dual-function SNF2 protein drives chromatid resolution and nascent transcript removal in mitosis". EMBO reports (2023): https://doi.org/10.15252/embr.202256463.
    10.15252/embr.202256463
  2. Inês Milagre; Carolina Pereira; Raquel A. Oliveira. "Compromised Mitotic Fidelity in Human Pluripotent Stem Cells". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241511933.
    10.3390/ijms241511933
  3. Margarida Araújo; Alexandra Tavares; Diana V Vieira; Ivo A Telley; Raquel A Oliveira. "Endoplasmic reticulum membranes are continuously required to maintain mitotic spindle size and forces". Life Science Alliance (2023): https://doi.org/10.26508/lsa.202201540.
    10.26508/lsa.202201540
  4. Mário A. F. Soares; Raquel A. Oliveira; Diogo S. Castro. "Function and regulation of transcription factors during mitosis-to-G1 transition". Open Biology (2022): https://doi.org/10.1098/rsob.220062.
    10.1098/rsob.220062
  5. Carvalhal, Sara; Bader, Ingrid; Rooimans, Martin A.; Oostra, Anneke B.; Balk, Jesper A.; Feichtinger, René G.; Beichler, Christine; et al. Corresponding author: Oliveira, Raquel A.. "Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation". Science Advances 8 3 (2022): http://dx.doi.org/10.1126/sciadv.abk0114.
    Published • 10.1126/sciadv.abk0114
  6. Mário A.F. Soares; Diogo S. Soares; Vera Teixeira; Abeer Heskol; Raul Bardini Bressan; Steven M. Pollard; Raquel A. Oliveira; Diogo S. Castro. "Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells". Genes & Development (2021): https://doi.org/10.1101/gad.348174.120.
    10.1101/gad.348174.120
  7. Milagre, Inês; Pereira, Carolina; Oliveira, Raquel A.; Jansen, Lars E. T.. "Reprogramming of human cells to pluripotency induces CENP-A chromatin depletion". Open Biology 10 10 (2020): 200227. http://dx.doi.org/10.1098/rsob.200227.
    10.1098/rsob.200227
  8. Mihailo Mirkovic; Leonardo G. Guilgur; Alexandra Tavares; Diogo Passagem-Santos; Raquel A. Oliveira. "Induced aneuploidy in neural stem cells triggers a delayed stress response and impairs adult life span in flies". PLOS Biology 17 2 (2019): e3000016-e3000016. https://doi.org/10.1371/journal.pbio.3000016.
    10.1371/journal.pbio.3000016
  9. Sara Carvalhal; Alexandra Tavares; Mariana B. Santos; Mihailo Mirkovic; Raquel A. Oliveira. "A quantitative analysis of cohesin decay in mitotic fidelity". The Journal of Cell Biology 217 10 (2018): 3343-3353. https://doi.org/10.1083/jcb.201801111.
    10.1083/jcb.201801111
  10. Silva, Rui D.; Mirkovic, Mihailo; Guilgur, Leonardo G.; Rathore, Om S.; Martinho, Rui Gonçalo; Oliveira, Raquel A.. "Absence of the Spindle Assembly Checkpoint Restores Mitotic Fidelity upon Loss of Sister Chromatid Cohesion". Current Biology 28 17 (2018): 2837-2844.e3. http://dx.doi.org/10.1016/j.cub.2018.06.062.
    10.1016/j.cub.2018.06.062
  11. Piskadlo, E.; Oliveira, R.A.. "A topology-centric view on mitotic chromosome architecture". International Journal of Molecular Sciences 18 12 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85038438457&partnerID=MN8TOARS.
    10.3390/ijms18122751
  12. Piskadlo, E.; Tavares, A.; Oliveira, R.A.. "Metaphase chromosome structure is dynamically maintained by condensin I-directed DNA (de)catenation". eLife 6 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85020385825&partnerID=MN8TOARS.
    10.7554/eLife.26120
  13. Piskadlo, E.; Oliveira, R.A.. "Novel insights into mitotic chromosome condensation [version 1; referees: 2 approved]". F1000Research 5 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85010934339&partnerID=MN8TOARS.
    10.12688/F1000RESEARCH.8727.1
  14. Mirkovic, M.; Hutter, L.H.; Novák, B.; Oliveira, R.A.. "Premature Sister Chromatid Separation Is Poorly Detected by the Spindle Assembly Checkpoint as a Result of System-Level Feedback". Cell Reports 13 3 (2015): 469-478. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944674560&partnerID=MN8TOARS.
    10.1016/j.celrep.2015.09.020
  15. Oliveira, R.A.; Kotadia, S.; Tavares, A.; Mirkovic, M.; Bowlin, K.; Eichinger, C.S.; Nasmyth, K.; Sullivan, W.. "Centromere-Independent Accumulation of Cohesin at Ectopic Heterochromatin Sites Induces Chromosome Stretching during Anaphase". PLoS Biology 12 10 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84920449718&partnerID=MN8TOARS.
    10.1371/journal.pbio.1001962
  16. Zhang, T.; Oliveira, R.A.; Schmierer, B.; Novák, B.. "Dynamical scenarios for chromosome bi-orientation". Biophysical Journal 104 12 (2013): 2595-2606. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879230092&partnerID=MN8TOARS.
    10.1016/j.bpj.2013.05.005
  17. Eichinger, C.S.; Kurze, A.; Oliveira, R.A.; Nasmyth, K.. "Disengaging the Smc3/kleisin interface releases cohesin from Drosophila chromosomes during interphase and mitosis". EMBO Journal 32 5 (2013): 656-665. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875226268&partnerID=MN8TOARS.
    10.1038/emboj.2012.346
  18. Oliveira, R.A.; Nasmyth, K.. "Cohesin cleavage is insufficient for centriole disengagement in Drosophila". Current Biology 23 14 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880688089&partnerID=MN8TOARS.
    10.1016/j.cub.2013.04.003
  19. He, E.; Kapuy, O.; Oliveira, R.A.; Uhlmann, F.; Tyson, J.J.; Novák, B.. "System-level feedbacks make the anaphase switch irreversible". Proceedings of the National Academy of Sciences of the United States of America 108 24 (2011): 10016-10021. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959918208&partnerID=MN8TOARS.
    10.1073/pnas.1102106108
  20. Nasmyth, K.; Oliveira, R. A.. "Splitting the Nucleus: What's Wrong with the Tripartite Ring Model?". Cold Spring Harbor Symposia on Quantitative Biology 75 0 (2010): 375-388. http://dx.doi.org/10.1101/sqb.2010.75.019.
    10.1101/sqb.2010.75.019
  21. Oliveira, R.A.; Nasmyth, K.. "Getting through anaphase: Splitting the sisters and beyond". Biochemical Society Transactions 38 6 (2010): 1639-1644. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649751231&partnerID=MN8TOARS.
    10.1042/BST0381639
  22. Pauli, A.; Van Bemmel, J.G.; Oliveira, R.A.; Itoh, T.; Shirahige, K.; Van Steensel, B.; Nasmyth, K.. "A direct role for cohesin in gene regulation and ecdysone response in drosophila salivary glands". Current Biology 20 20 (2010): 1787-1798. http://www.scopus.com/inward/record.url?eid=2-s2.0-78049277571&partnerID=MN8TOARS.
    10.1016/j.cub.2010.09.006
  23. Hamilton, R.S.; Parton, R.M.; Oliveira, R.A.; Vendra, G.; Ball, G.; Nasmyth, K.; Davis, I.. "ParticleStats: Open source software for the analysis of particle motility and cytoskeletal polarity". Nucleic Acids Research 38 SUPPL. 2 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77954250305&partnerID=MN8TOARS.
    10.1093/nar/gkq542
  24. Oliveira, R.A.; Hamilton, R.S.; Pauli, A.; Davis, I.; Nasmyth, K.. "Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei". Nature Cell Biology 12 2 (2010): 185-192. http://www.scopus.com/inward/record.url?eid=2-s2.0-75949117626&partnerID=MN8TOARS.
    10.1038/ncb2018
  25. Pauli, A.; Althoff, F.; Oliveira, R.A.; Heidmann, S.; Schuldiner, O.; Lehner, C.F.; Dickson, B.J.; Nasmyth, K.. "Cell-Type-Specific TEV Protease Cleavage Reveals Cohesin Functions in Drosophila Neurons". Developmental Cell 14 2 (2008): 239-251. http://www.scopus.com/inward/record.url?eid=2-s2.0-38849173178&partnerID=MN8TOARS.
    10.1016/j.devcel.2007.12.009
  26. Oliveira, R.A.; Heidmann, S.; Sunkel, C.E.. "Condensin I binds chromatin early in prophase and displays a highly dynamic association with Drosophila mitotic chromosomes". Chromosoma 116 3 (2007): 259-274. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248146555&partnerID=MN8TOARS.
    10.1007/s00412-007-0097-5
  27. Oliveira, R.A.; Coelho, P.A.; Sunkel, C.E.. "The condensin I subunit Barren/CAP-H is essential for the structural integrity of centromeric heterochromatin during mitosis". Molecular and Cellular Biology 25 20 (2005): 8971-8984. http://www.scopus.com/inward/record.url?eid=2-s2.0-26444433291&partnerID=MN8TOARS.
    10.1128/MCB.25.20.8971-8984.2005
Preprint
  1. Jacob D. Bowman; Neide Silva; Erik Schüftan; Joana M. Almeida; Rion Brattig-Correia; Raquel A Oliveira; Frank Tüttelmann; et al. "Pervasive relaxed selection on spermatogenesis genes coincident with the evolution of polygyny in gorillas". 2023. http://dx.doi.org/10.1101/2023.10.27.564379.
    10.1101/2023.10.27.564379
  2. Cintia Horta; Alexandra Tavares; Raquel A Oliveira. Corresponding author: Raquel A Oliveira. "Condensin II is required for efficient Spindle Assembly Checkpoint activation in Drosophila male meiosis". 2022. Condensin II is required for efficient Spindle Assembly Checkpoint activation in Drosophila male meiosis.
    10.1101/2022.02.23.481572
  3. Catarina Carmo; João Coelho; Rui Silva; Alexandra Tavares; Ana Boavida; Paola Gaetani; Rui Gonçalo Martinho; Raquel A. Oliveira. "An SNF2 helicase-like protein links mitotic transcription termination to sister chromatid resolution". 2022. https://doi.org/10.1101/2022.11.21.517340.
    10.1101/2022.11.21.517340
  4. Margarida Araújo; Alexandra Tavares; Diana V. Vieira; Ivo A. Telley; Raquel A. Oliveira. "Endoplasmic Reticulum membranes are continuously required to maintain mitotic spindle size and forces". 2022. https://doi.org/10.1101/2022.05.14.491942.
    10.1101/2022.05.14.491942
  5. Soares, Mário A. F.; Soares, Diogo S.; Teixeira, Vera; Bressan, Raul Bardini; Pollard, Steven M.; Oliveira, Raquel A.; Castro, Diogo S.. "Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells". 2021. http://dx.doi.org/10.1101/2021.02.17.431407.
    10.1101/2021.02.17.431407
  6. Mirkovic, Mihailo; Guilgur, Leonardo G.; Passagem-Santos, Diogo; Oliveira, Raquel A.. "Delayed aneuploidy stress response of neural stem cells impairs adult lifespan in flies". 2018. http://dx.doi.org/10.1101/392746.
    10.1101/392746
  7. Silva, Rui D.; Mirkovic, Mihailo; Guilgur, Leonardo G.; Rathore, Om S.; Martinho, Rui Gonçalo; Oliveira, Raquel A.. "Absence of the Spindle Assembly Checkpoint restores mitotic fidelity upon loss of sister chromatid cohesion". 2018. http://dx.doi.org/10.1101/262204.
    10.1101/262204
Thesis / Dissertation
  1. Oliveira, Raquel. "Condensins and mitotic chromosome structure: functional and dynamic analysis in Drosophila melanogaster". PhD, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2007.
  2. Oliveira, Raquel. "Barley 14-3-3 interacting proteins purified by affinity chromatography". Degree, Vrije Universiteit Amsterdam, 2002.

Other

Other output
  1. Erratum. Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells (Genes & Development (2021) 35 (1020–1034) DOI: 10.1101/gad.348174.120). 2023. Mario A.F. Soares; Diogo S. Soares; Vera Teixeira; Abeer Heskol; Raul Bardini Bressan; Steven M. Pollard; Raquel A Oliveira; Diogo S. Castro. https://ciencia.ucp.pt/en/publications/776b3496-3652-49d0-aa52-feefc314c2a8.
    10.1101/gad.350810.123
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/02/05 Silencing chromosomes in mitosis CohesiNet knock-off meeting
CohesiNet Doctoral Network (Amsterdam, Netherlands)
2023/11 Silencing Chromosomes during mitosis genorg-2023 : Workshop on Genome Organizers
ENS de Lyon (France)
2023/11 A dança dos cromossomas durante a mitose Seminário Escolar
Agrupamento de Escolas D Dinis (Portugal)
2023/10 Silencing chromosomes in mitosis EMBO Young Scientists Forum
European Molecular Biology Organisation (Portugal)
2023/10 CHROMOSOME DYNAMICS IN MITOSIS EMBO members meeting
European Molecular Biology Organisation (Germany)
2023/10 PARSUK 15 anos… o passado LUSO 2023
PARSUK (United Kingdom)
2023/10 A criatividade no método científico Inovação na Morfose
Faculdade de Arquitetura - Universidade de Lisboa (Portugal)
2023/10 Mitotic chromosome organization: from basic principles to human disease iMed Conference
Faculdade de Medicina - Universidade Nova de Lisboa (Portugal)
2023/09 Chromosome dynamics during mitosis Opening session of the PDBEB PhD programme
Universidade de Coimbra (Portugal)
2023/09 Abnormal TOP2A distribution on mitotic chromosomes from rare developmental disorders EMBO Workshop on DNA topology and topoisomerases in genome dynamics
European Molecular Biology Organisation (Switzerland)
2022/12 Silencing chromosomes for mitosis Drostuga2022
Portuguese Drosophila meeting (Batalha, Portugal)
2022/10 Bridging mitotic transcriptional inactivation with sister chromatid resolution EMBO Workshop: The cell cycle: One engine – many cycles
EMBO (Konstanz, Germany)
2022/06 Gluing chromosomes in mitosis i3S Cancer Program Retreat
I3S Cancer Program (Porto, Portugal)
2022/05 Silencing chromosomes for mitosis EMBO Workshop: Chromosome segregation and aneuploidy
EMBO (Vienna, Austria)
2022 A mosca da fruta em investigação biomédica Workshop em Modelos Animais
Universidade de évora (Évora, Portugal)
2021/06 Chromosome dynamics during mitosis Ciencia 2021
Fundação para a Ciencia e Tecnologia (FCT) (Lisbon, Portugal)
2021/02/15 Guiding topoisomerase 2 activity during mitosis 3rd meeting of EUTOPIA
http://eutopia3.campus.ciencias.ulisboa.pt
2021/02 The chromosome Dance International Day of Women and Girls in Science: how ¿ scientists do it!
Joint Research Center (JRC)
2021 Bridging mitotic transcription inactivation and sister chromatid resolution by the dual function SNF2 helicase-like protein Lodestar EMBO Workshop “DNA Topology in genomic transactions”
2020/12/16 Biallelic mutations in BUB1 causes different chromosome segregation errors in mitosis in patients with intrinsic aneuploidy Aneuploidy and CIN Zoom forum - in remembrance of Angelika Amon
2019/09/18 New (and old) regulators of faithful chromosome segregation - EMBO Workshop on DNA topology and topoisomerases in genome dynamics, Les Diablerets, Switzerland EMBO Workshop on DNA topology and topoisomerases in genome dynamics
EMBO (Les Diablerets, Switzerland)
2019/06 Condensin II in Drosophila male meiosis, EMBO workshop: Organization of bacterial and eukaryotic genomes by SMC complexes, Vienna, Austria Organization of bacterial and eukaryotic genomes by SMC complexes
EMBO (Vienna, Austria)
2018/09/17 Aneuploidy tolerance of neural stem cells impairs adult lifespan in flies, Annual meeting Portuguese Genetics Society, Porto, Portugal Annual meeting Portuguese Genetics Society
Portuguese Genetics Society (Porto, Portugal)
2018/06/06 Coping with wrong chromosome numbers during development, EMBO Workshop: Molecular and developmental biology of Drosophila. Crete, Greece EMBO Workshop: Molecular and developmental biology of drosophila Greece
EMBO (Crete, Greece)
2017/09/15 Coping with wrong chromosome numbers during development, 2017 JEDI Meeting, Italy 2017 JEDI Meeting
JEDI (Italy)
2017/09/10 Chromosome Dynamics, EMBO workshop on DNA topoisomerases and DNA topology Switzerland EMBO workshop on DNA topoisomerases and DNA topology
EMBO (Les Diablerets, Switzerland)
2017/06/16 Chromosome dynamics during mitosis, Research Seminar: University of Bayreuth Research Seminar: University of Bayreuth
Stefan Heidmann, University of Bayreuth (Bayreuth, Germany)
2017/05/15 Condensin I Directs Sister Chromatid Resolution Throughout Metaphase, Chromosome Dynamics, Gordon Research Conference, Lucca Italy Chromosome Dynamics, Gordon Research Conference
Gordon Research Conferences (Lucca, Italy)
2016/09/12 Chromosome dynamics during mitosis, EMBO Young Scientists Forum, Lisbon, Portugal EMBO Young Scientists Forum
EMBO (Lisbon, Portugal)
2016/07/05 Dissecting chromosome structure by acute protein inactivation, EMBO workshop Chromosome Segregation and Aneuploidy - Chromo2016, Galway Ireland EMBO workshop Chromosome Segregation and Aneuploidy - Chromo2016
EMBO (Galway, Ireland)
2016/06/11 Immediate and long-term consequences of premature loss of sister chromatid cohesion”, Causes and consequences of aneuploidy, Les Treilles, France Causes and consequences of aneuploidy
Les treilles Foundation (Les Treilles, France)
2016/05/15 Chromosome dynamics during mitosis, EMBO YIP meeting, Heidelberg, Germany EMBO YIP meeting
(Heidelberg,, Germany)
2015/09/15 Building up mitotic chromosomes: sister chromatid resolution and chromatin compaction, EMBO Workshop on DNA Topoisomerases, DNA topology and Human Health , Les Diablerets, Switzerland EMBO Workshop on DNA Topoisomerases, DNA topology and Human Health
EMBO (Les Diablerets, Switzerland)
2015/05/21 How do cells deal with premature sister chromatid separation?, EMBO workshop: Dynamic kinetochore, Copenhagen, Denmark EMBO workshop: Dynamic kinetochore
EMBO (Copenhagen,, Denmark)
2015/05/14 Condensins and mitotic chromosome organization: sister chromatid resolution vs chromatin compaction, EMBO Workshop: SMC proteins - Chromosomal organizers from bacteria to human, Vienna, Austria EMBO Workshop: SMC proteins - Chromosomal organizers from bacteria to human
EMBO (Vienna, Austria)
2014/06/30 Sister chromatid cohesion: not too little, not too much, Institute seminar: Karolinska Institute Institute seminar: Karolinska Institute
Karolinska Institute (Stockholm, Sweden)
2014/06/15 Packing and Gluing DNA molecules for mitosis, Annual Young Investigator Programme meeting (YIP), Heidelberg, Germany Annual Young Investigator Programme meeting (YIP)
EMBO YIP (Heidelberg, Germany)
2013/09/14 Centromere-independent accumulation of cohesin at ectopic heterochromatin sites induces chromosome stretching during anaphase, EMBO Drosophila Cell Cycle Workshop, Devon, UK EMBO Drosophila Cell Cycle Workshop
EMBO (Devon, United Kingdom)
2013/08/14 Packing and gluing DNA molecules for mitosis, Research Seminar: MRC Clinical Sciences Centre, Imperial College London, UK Research Seminar: MRC Clinical Sciences Centre, Imperial College London, UK
Luis Aragon (London, United Kingdom)
2013/05/16 Centromere vs heterochromatin: What determines cohesin’s pericentromeric accumulation? Dynamic Kinetochore workshop, Porto, Portugal Dynamic Kinetochore workshop
European Molecular Biology Organization (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09 - Current Examining the impact of novel cohesion regulators in chromosomal segregation fidelity
Supervisor
 Biomedical Science and Engineering (PhD)
Universidade Católica Portuguesa - Católica Biomedical Research Centre, Portugal
2022 - Current Mechanisms of mitotic transcription inactivation
Supervisor
 Biological Sciences (PhD)
Instituto Gulbenkian de Ciência, Portugal
2021 - Current Improving Mitotic Fidelity in Pluripotent Stem Cells
Supervisor
 Biological Sciences (PhD)
Instituto Gulbenkian de Ciência, Portugal
2021 - Current How mitotic transcription inactivation can modulate cell fate and cell identity?
Supervisor
 Biological Sciences (PhD)
Instituto Gulbenkian de Ciência, Portugal
2017 - Current Deciphering the Minimal Histone Landscape required for mitotic chromosome compaction
Supervisor
Instituto Gulbenkian de Ciência, Portugal
2023 - 2024 Identification and characterization of novel regulators of mitotic fidelity
Supervisor
 Biochemistry for Health (Master)
Universidade NOVA de Lisboa, Portugal
2017 - 2023/01 Endoplasmic Reticulum membranes are continuously required to maintain mitotic spindle size and forces
Supervisor
 Integretive Biology and Biomedicine (PhD)
Instituto Gulbenkian de Ciência, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020 - 2021 A comprehensive analysis of the role of TTF2/ Lds throughout the cell cycle
Co-supervisor
 Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/07/01 - 2019/12/09 Transcription factor-dependent regulation of neural stem cell identity throughout mitosis
Co-supervisor
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/07/01 - 2019/07/22 Dissecting Non-Canonical Roles of Condensin Complexes
Supervisor
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/07/01 - 2018/07/18 Cohesion failure and Mitosis: From Molecular Mechanisms to Organismal Consequences
Supervisor of Mihailo Mirkovic
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013/07/01 - 2017/10/20 Maintenance of metaphase chromosome architecture by condensin I
Supervisor of Ewa Renata Piskadlo
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013/07/01 - 2014/09/15 Cohesion decay: quantitative analysis of partial sister chromatid cohesion
Supervisor of Mariana Batista Santos
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012/07/01 - 2013/12/06 Super-resolution imaging of the structural maintenance of chromosome (SMC) complexes cohesin and condensin
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023 - 2023 EMBO Workshop DNA topology and topoisomerases in genome dynamics (2023/09/03 - 2023/09/07)
Conference (Co-organisor)
 European Molecular Biology Organization (EMBO), Germany
2019/05/11 - 2019/05/15 2019 EMBO workshop on Chromosome Segregation and Aneuploidy 11 – 15 May 2019 | Cascais, Portugal (2019/05/11 - 2019/05/15)
Conference (Co-organisor)
 European Molecular Biology Organization (EMBO), Germany
2017/09/17 - 2017/09/21 2017 EMBO workshop on DNA topoisomerases and Topology (http://meetings.embo.org/event/17-topoisomerase) 17 – 21 September | Les Diablerets, Switzerland (2017/09/17 - 2017/09/21)
Conference (Co-organisor)
 European Molecular Biology Organization (EMBO), Germany
2016 - 2017 2016&2017 Co-organizer of JEDI meeting (http://jedi2016.hu/ and https://jedi2017.azuleon.org) (2016 - 2017)
Conference (Co-organisor)
 JEDI - Junior European Drosophila Investigators, United Kingdom
2016 - 2016 2016 EMBO Young Scientists Forum (http://events.embo.org/16-eysf/) (2016 - 2016)
Conference (President of the Organising Committee)
 European Molecular Biology Organization (EMBO), Germany
2012 - 2015 2012 and 2015 DrosTuga meeting, Annual meeting of Portuguese Researcher using Drosophila Melanogaster as model system (2012 - 2015)
Conference (Co-organisor)
2010 - 2012 2010 & 2012 Organizer of “PARSUK Communicating Science”, a workshop sponsored by the Portuguese Association of Researchers and Students in the United Kingdom, aiming to teach young scientists to discuss their research with the media and lay audiences. Oriel College, Oxford (2010) and Homerton College, Cambridge (2012), United Kingdom (~20 participants) (2010 - 2012)
Workshop (Co-organisor)
 Portuguese Association of Students and Researchers in the United Kingdom (PARSUK), United Kingdom
2008 - 2008 2008 Organizer of LUSO2008, the second annual meeting of Portuguese students and researchers in the United Kingdom, held in Oxford on the 21st of June, 2008 (~200 participants). (2008 - 2008)
Conference (Co-organisor)
 Portuguese Association of Students and Researchers in the United Kingdom (PARSUK), United Kingdom

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2012 - Current Participation in several Science Communication activities (IGC Open Day, “Café Ciência”, “Amigos dos Castelos and Portugueses na Ciência”, “Lab escolas”, “Music and Science, FCG”).

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023 Influenza A virus inclusions are liquid condensates that can be pharmacologically hardened
(Thesis) Arguer
 Temitope Akhigbe Etibor (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2023 Understanding Plk4’s role in Cancer
(Thesis) Arguer
 Irina Suheila Martins Leal Fonseca (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2023 Improvement of aging hallmarks through mitotic epigenetic bookmarking
(Thesis) Main arguer
 Maria Mendes da Silva (Master)
Universidade de Coimbra, Portugal
2023 Shifting gears: insights into the head to trunk transition Exploring the regulatory changes underlying the head to trunk developmental transition
(Thesis) Arguer
 Patricia Duarte (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2022 SR Proteins and Pre-mRNA Splicing in ABA Signaling and Metabolism
(Thesis) Arguer
 Rui Filipe dos Reis Mata Albuquerque Martins (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2022 Identification of novel CENP-A maintenance mechanisms
(Thesis) Arguer
 Sebastiaan van den Berg (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/06/04 Genetic instability: from genome content variations to gene expression plasticity
(Thesis) Main arguer
 Alix GOUPIL (PhD)
Institut Curie, France
2021/03/19 Dissecting the role of Polo kinase in the regulation of kinetochore-microtubule attachments
(Thesis) Main arguer
 João Francisco Portugal Antas de Barros Barbosa (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/10/31 On the origins of chromosomal instability and karyotype heterogeneity in colorectal cancer
(Thesis) Main arguer
 Ana Bolhaqueiro (PhD)
Hubrecht Institute, Netherlands
2019/10/20 Identification of novel conserved dynein pathway genes using a genome-wide synthetic lethal screen in C. elegans
(Thesis) Main arguer
 Helder Henrique Ribeiro Rocha (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/11/10 Deciphering the consequences of polyploidy in an in vivo epithelium
(Thesis) Main arguer
 Carmo Castilho Soares (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2017/01/12 A bioinformatics and systems biology approach to investigate Drosophila melanogaster kinetochore proteins
(Thesis) Main arguer
 Yaseen Noorahmed Ladak (PhD)
University of Oxford, United Kingdom
2015 Mimicking chromosomal instability observed in cancer - a study in Mouse Embryonic Fibroblasts
(Thesis) Main arguer
 Rita Gaspar Cabrita (Master)
Universidade de Lisboa, Portugal
2014/05/22 Kinetochore-microtubule interaction regulation
(Thesis) Main arguer
 Tália Cláudia Feijão Moreira Figueiredo (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012/07/17 Microtubule Dynamics in interphase and tension sensing in mitosis
(Thesis) Main arguer
 Aureliana Filipa de Castro e Sousa (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Association member

Society Organization name Role
2018 - Current Portuguese Genetics Society member
2008 - Current PARSUK- Portuguese Association of Students and Researchers in the United Kingdom Co-Founder; President 2008-2009; President General Assembly 2009-2010 and 2010-2011; alumni member since 2012.
2005 - Current American Society for Cell Biology member
2000 - Current Portuguese Biochemical Society member

Committee member

Activity description
Role 		Institution / Organization
2021 - Current Scientific Advisory Board of PARSUK (Portuguese Association of Researchers and Students in the UK (PARSUK))
Member
 Portuguese Association of Researchers and Students in the United Kingdom (PARSUK), United Kingdom

Consulting

Activity description Institution / Organization
2021 - Current Career Advisor at Chaperone.online (Individual and personalized career guidance for scientists).
2012 - Current Reviewer for various journals in the field: Cell, Nature Cell Biology, Cell Reports, Science Advances, PNAS, EMBO Journal, EMBO Reports, eLife, Plos Genetics, Molecular Biology of the Cell, Journal of Cell Science and Open Biology
2012 - 2017 Faculty member at Faculty of 1000 Biology, Cell Growth & Division section (http://f1000biology.com/about/biography/8160652672451987) (2012-2017)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2013/01/01 - 2020/12/31 2019 EMBO Cell Biology Course, Heidelberg, Germany 2017 EMBO YIP PhD Course, Heidelberg, Germany 2012-2019 Gulbenkian PhD programme, Oeiras, Portugal (co-organizer of “Inside the Cell” module) 2014-2016 Graduate Program Science for Development (PGDC), Praia, Cape Verde 2012 GABBA Graduate Programme, IBMC, Porto, Portugal 2012-2013 Masters programme in Developmental and Evolutionary Biology”, Faculdade de Ciências, Universidade de Lisboa, Faculdade de Ciências, Lisbon, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2022 - 2024 Member of the LS1 Pannel for SNSF Consolidator Grants (SNSF Horizon Europe Transition Measures)
Evaluator
 Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung, Switzerland Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung
2019 - 2020 IBB PhD Programme Committee https://gulbenkian.pt/ciencia/training/phd-programmes/ibb/ Instituto Gulbenkian de Ciência, Portugal
2013 - 2014 2013 and 2014 Panel Member for evaluation of individual PhD/Postdoctoral Fellowships awarded by the Portuguese Research Council (Fundação para a Ciência e Tecnologia), Portugal Fundação para a Ciência e a Tecnologia, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2021 A summary of all media appearances can be found here: https://www.chromosomedynamicslab.com/in-the-news.html

Interview (tv / radio show)

Program Topic
2022 - Current RTP Telejornal Science Advances Paper (Carvalhal et al)
2022 - Current e=mc2 Detetados primeiros casos de doença rara por erros na divisão celular

Other jury / evaluation

Activity description Institution / Organization
2012 - Current External Reviewer for several National and International Grant Agencies: Vienna Science and Technology Fund (WWTF) (Austria); Vienna International Postdoctoral Program (VIP2) (Austria); BBSRC (UK); KWF Kankerbestrijding (Dutch Cancer Society), (The Netherlands); Dutch Research Council (NWO) Talent Programme, (The Netherlands); Science Foundation Ireland (SFI) (Ireland); Graduate Women in Science Fellowships (USA); Fundo iMM-Laço (Portugal).
2017 - 2018 • Jury in the “Fame-Lab” semi-finals, a science communication national competition (2017 and 2018) British Council Portugal, Portugal
Distinctions

Award

2016 Prémio Revelação Dona Antónia Adelaide Ferreira 2015

Title

2022 EMBO member
European Molecular Biology Organization (EMBO), Germany

Other distinction

2020 European Research Council - Consolidator Grant
European Research Council, Belgium
2018 CEEC-Ind 2017
Fundação para a Ciência e a Tecnologia, Portugal
2014 European Research Council Starting Grant
European Research Council, Belgium
2013 FCT Investigator
Fundação para a Ciência e a Tecnologia, Portugal
2013 Marie Curie Career Integration Grant
2013 EMBO Installation Grant
2011 Best Poster at departmental annual post-doc poster session
2008 Bolsa de Pós-doutoramento
Fundação para a Ciência e a Tecnologia, Portugal
2005 Predoctoral ASCB travel award
American Society for Cell Biology, United States
2002 Bolsa de Doutoramento (Programa Doutoral em Biologia Experimental e Biomedicina)
Fundação para a Ciência e a Tecnologia, Portugal
2002 Bolsa de mobilidade ERASMUS
Universidade do Porto, Portugal