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Mafalda Lopes da Silva. Completed her Bachelor in Biology with Microbiology em 2005 at Imperial College London. Completed her PhD in Cellular Biology in 2011 at the Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica. Has been a Post-doc at the Laboratory of Molecular Cell Biology at University College London (UCL), and is currently a Post-doc at Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas. She has published 11 peer-review articles in specialised journals.
Identification

Personal identification

Full name
Mafalda Lopes da Silva

Citation names

  • Lopes-da-Silva, Mafalda
  • Lopes da Silva, Mafalda

Author identifiers

Ciência ID
D61C-CD89-BE32
ORCID iD
0000-0001-7651-8656

Addresses

  • Universidade NOVA de Lisboa – NOVA Medical School – Chronic Diseases Research Center (CEDOC). Rua Câmara Pestana 6, 1150-081, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Microbiology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Spanish; Castilian Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2) Intermediate (B1)
Education
Degree Classification
2011/05/01
Concluded
 Biologia Celular (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Dissecting the molecular interaction between hepatocytes and Plasmodium liver parasites" (THESIS/DISSERTATION)
 aprovada por unanimidade
2005/06/30
Concluded
 Biology with Microbiology (Bachelor)
Imperial College London, United Kingdom
 16
Affiliation

Science

Category
Host institution 		Employer
2020/08 - 2025/08 Contracted Researcher (Research) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Others

Category
Host institution 		Employer
2018/05 - 2020/08 Pos-Doc Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2012/04/01 - 2018/04/01 Post-Doc MRC Laboratory for Molecular Cell Biology, United Kingdom
2011/06/01 - 2012/04/01 Post-Doc National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, United Kingdom
2006/01/01 - 2011/05/25 PhD in Cellular Biology Instituto Gulbenkian de Ciência, Portugal
Projects

Grant

Designation Funders
2019/05 - 2020/07 Molecular mechanisms of melanin internalization and processing by keratinocytes
PTDC/BIA-CEL/29765/2017
Post-doc
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/05 - 2019/05 Developing novel modulators of skin pigmentation.
UID/Multi/04462/2013
Post-doc
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 iNOVA4Health
Concluded
2012/04 - 2018/03 Modulation of endothelial organelle size as an antithrombotic strategy
MC_UU_12018/2
Post-doc
MRC Laboratory for Molecular Cell Biology, United Kingdom
 Medical Research Council
Concluded
2010/02 - 2013/07 Subversion of the host endocytic pathway by Plasmodium sporozoites
PTDC/SAU-MII/108206/2008
PhD Student Fellow
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/10 - 2010/03 Molecular mechanisms of formation of the parasitic vacuole in Malaria infection
PTDC/SAU-MII/72027/2006
PhD Student Fellow
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2020/08 - 2025/08 Keratinocyte and melanocyte cross-talk during pigmentation
CEECIND/01536/2018
Researcher
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2006/01 - 2011/01 Dissecting the molecular interactions between hepatocytes and Plasmodium liver parasites
SFRH/BD/27705/2006
PhD Student Fellow
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Journal article
  1. Tatiana Burrinha; César Cunha; Michael J. Hall; Mafalda Lopes-da-Silva; Miguel C. Seabra; Cláudia Guimas Almeida. "Deacidification of endolysosomes by neuronal aging drives synapse loss". Traffic (2023): https://doi.org/10.1111/tra.12889.
    10.1111/tra.12889
  2. Rita Rosado-Ramos; Gonçalo Manuel Poças; Daniela Marques; Alexandre Foito; David M. Sevillano; Mafalda Lopes-da-Silva; Luís G. Gonçalves; et al. "Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage". Nature Communications (2023): http://dx.doi.org/10.1038/s41467-023-37561-2.
    10.1038/s41467-023-37561-2
  3. Ana F. Raimundo; Sofia Ferreira; Vânia Pobre; Mafalda Lopes-da-Silva; José A. Brito; Daniel J. V. A. dos Santos; Nuno Saraiva; Cláudia N. dos Santos; Regina Menezes. "Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes". Frontiers in Endocrinology (2022): http://dx.doi.org/10.3389/fendo.2022.1008418.
    10.3389/fendo.2022.1008418
  4. Karen M. Page; Jessica J. McCormack; Mafalda Lopes-da-Silva; Francesca Patella; Kimberly Harrison-Lavoie; Jemima J. Burden; Ying-Yi Bernadette Quah; et al. "Structure modeling hints at a granular organization of the Golgi ribbon". BMC Biology (2022): https://doi.org/10.1186/s12915-022-01305-3.
    10.1186/s12915-022-01305-3
  5. Eva Alegre Cortés; Alberto Giménez-Bejarano; Elisabet Uribe Carretero; Marta Paredes-Barquero; André R. A. Marques; Mafalda Lopes-da-Silva; vieira o; et al. "Delay of EGF-Stimulated EGFR Degradation in Myotonic Dystrophy Type 1 (DM1)". Cells (2022): http://dx.doi.org/10.3390/cells11193018.
    10.3390/cells11193018
  6. Karen M. Page; Jessica J. McCormack; Lopes-da-Silva, Mafalda; Francesca Patella; Kimberly Harrison-Lavoie; Jemima J. Burden; Ying-Yi Bernadette Quah; et al. Corresponding author: Daniel F. Cutler. "Structure modeling hints at a granular organization of the Vertebrate Golgi ribbon". bioRxiv 08 30 (2021): 458089. https://www.biorxiv.org/content/10.1101/2021.08.30.458089v1.
    Open access • Accepted
  7. Escrevente, Cristina; Falcão, Ana S.; Hall, Michael J.; Lopes-da-Silva, Mafalda; Antas, Pedro; Mesquita, Miguel M.; Ferreira, Inês S.; et al. "Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction". Investigative Opthalmology & Visual Science 62 9 (2021): 39. http://dx.doi.org/10.1167/iovs.62.9.39.
    10.1167/iovs.62.9.39
  8. Moreiras H; Lopes-da-Silva M; Seabra MC; Barral DC. "Melanin processing by keratinocytes: A non-microbial type of host-pathogen interaction?". Traffic (Copenhagen, Denmark) (2019): http://europepmc.org/abstract/med/30801937.
    10.1111/tra.12638
  9. Lopes-da-Silva M; McCormack JJ; Burden JJ; Harrison-Lavoie KJ; Ferraro F; Cutler DF. "A GBF1-Dependent Mechanism for Environmentally Responsive Regulation of ER-Golgi Transport.". Developmental cell (2019): http://europepmc.org/abstract/med/31056345.
    10.1016/j.devcel.2019.04.006
  10. Nightingale TD; McCormack JJ; Grimes W; Robinson C; Lopes da Silva M; White IJ; Vaughan A; Cramer LP; Cutler DF. "Tuning the endothelial response: differential release of exocytic cargos from Weibel-Palade bodies.". Journal of thrombosis and haemostasis : JTH (2018): http://europepmc.org/abstract/med/29956444.
    10.1111/jth.14218
  11. McCormack JJ; Lopes da Silva M; Ferraro F; Patella F; Cutler DF. "Weibel-Palade bodies at a glance.". Journal of cell science (2017): http://europepmc.org/abstract/med/29093059.
    10.1242/jcs.208033
  12. Ferraro F; da Silva ML; Grimes W; Lee HK; Ketteler R; Kriston-Vizi J; Cutler DF. "Erratum: Weibel-Palade body size modulates the adhesive activity of its von Willebrand Factor cargo in cultured endothelial cells.". Scientific reports (2016): http://europepmc.org/abstract/med/27666678.
    10.1038/srep33938
  13. Lopes da Silva M; O'Connor MN; Kriston-Vizi J; White IJ; Al-Shawi R; Simons JP; Mössinger J; Haucke V; Cutler DF. "Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells.". Journal of cell science (2016): http://europepmc.org/abstract/med/27068535.
    10.1242/jcs.187864
  14. Lopes da Silva M; Cutler DF. "von Willebrand factor multimerization and the polarity of secretory pathways in endothelial cells.". Blood (2016): http://europepmc.org/abstract/med/27106123.
    10.1182/blood-2015-10-677054
  15. Thieleke-Matos C; Lopes da Silva M; Cabrita-Santos L; Portal MD; Rodrigues IP; Zuzarte-Luis V; Ramalho JS; et al. "Host cell autophagy contributes to Plasmodium liver development.". Cellular microbiology (2015): http://europepmc.org/abstract/med/26399761.
    10.1111/cmi.12524
  16. Thieleke-Matos C; da Silva ML; Cabrita-Santos L; Pires CF; Ramalho JS; Ikonomov O; Seixas E; et al. "Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection.". Traffic (Copenhagen, Denmark) (2014): http://europepmc.org/abstract/med/24992508.
    10.1111/tra.12190
  17. Wavre-Shapton ST; Tolmachova T; Lopes da Silva M; Futter CE; Seabra MC. "Correction: Conditional Ablation of the Choroideremia Gene Causes Age-Related Changes in Mouse Retinal Pigment Epithelium.". PloS one (2013): http://europepmc.org/abstract/PMC/PMC3654017.
    10.1371/annotation/83a88285-e6a0-41fb-ae67-4315c21e5090
  18. Lopes da Silva M; Thieleke-Matos C; Cabrita-Santos L; Ramalho JS; Wavre-Shapton ST; Futter CE; Barral DC; Seabra MC. "The host endocytic pathway is essential for Plasmodium berghei late liver stage development.". Traffic (Copenhagen, Denmark) (2012): http://europepmc.org/abstract/med/22780869.
    10.1111/j.1600-0854.2012.01398.x
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/11/06 Using CLEM to unravel intracellular membrane trafficking defects SPAOM, Spanish and Portuguese Advanced Optical Microscopy meeting
Portuguese Microscopy Society (Coimbra, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020/02/09 - 2020/02/14 COST Training school on CLEM, Instituto Gulbenkian Ciencia, Oeiras, Portugal. Co-organiser and taught theoretical and practical sessions. (2020)
Workshop (Co-organisor)
 Instituto Gulbenkian de Ciência, Portugal
2009 - 2009 EMBO Course on Light Microscopy in Living Cells (2009 - 2009)
Workshop (Co-organisor)
 Instituto Gulbenkian de Ciência, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/12/01 - 2021/12/10 Cell Biology 2021 Virtual-an Online ASCB|EMBO Meeting
Conference
 Cell Biology 2021 Virtual-an Online ASCB|EMBO Meeting
2021/02/15 - 2021/02/17 ZEISS - From 3D Light to 3D Electron Microscopy Lobby
Conference
 ZEISS - From 3D Light to 3D Electron Microscopy Lobby
The Francis Crick Institute, United Kingdom
2020/12/18 - 2020/12/18 UK Membrane Trafficking meeting
Conference
MRC Laboratory for Molecular Cell Biology, United Kingdom
2020/12/02 - 2020/12/16 Cell Biology 2020 Virtual-an Online ASCB|EMBO Meeting
Conference
 Cell Bio 2020 Virtual-an Online ASCB|EMBO Meeting
The American Society for Cell Biology, United States
2018/05 - 2018/05 EMBO Lab management Course for future Group Leaders
Workshop
 Lab management Course for future Group Leaders
European Molecular Biology Laboratory, Germany

MRC Laboratory for Molecular Cell Biology, United Kingdom

Mentoring / Tutoring

Topic Student name
2021/09/01 - 2022/09/01 Supervised a Master’s student Rita Coelho
2020/01/05 - 2020/04/30 Co-supervised a Master's student Guglielmo Pacetta
2012 - 2015 Co-supervised a PhD student David Westmorland
Distinctions

Other distinction

2019 CEEC Contract (CEECIND/01536/2018)
Fundação para a Ciência e a Tecnologia, Portugal
2006 PhD fellowship
Fundação para a Ciência e a Tecnologia, Portugal