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Andreia Albuquerque-Wendt graduated from the Medical School of Hannover in 2018 where she focused on glycan modifications of TSRs in C. elegans and Toxoplasma gondii proteins, as part of the Marie Curie International Training Network "GLYCOPAR". As a Marie Curie postdoctoral fellow she joined the University of Oxford, where she first started exploring the function of transporter proteins in the biology of Leishmania parasites using CRISPR/Cas9. She then continued the functional dissection of the Leishmania transportome in this parasites' life cycle using BARseq strategies at the University of Glasgow and the University of Bern. Currently, she is a member of the Vector Borne Diseases group of the Global Health and Tropical Medicine Centre, hosted by IHMT-UNL and a Marie Curie Global fellow at both Charles University and Swiss TPH.
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Identification

Personal identification

Full name
Andreia Albuquerque Wendt

Citation names

  • Wendt, Andreia
  • Albuquerque, Andreia
  • Albuquerque-Wendt, Andreia

Author identifiers

Ciência ID
D71C-9907-63EB
ORCID iD
0000-0001-5794-5417

Email addresses

  • andreia.albuquerquewendt@swisstph.ch (Professional)

Addresses

  • Swiss Tropical And Public Health Institute, Kreuzstrasse 2, 4123, Allschwil, Basel, Switzerland (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Entomology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
German Elementary (A2) Intermediate (B1) Elementary (A2) Intermediate (B1)
Education
Degree Classification
2018
Concluded
 Molecular Medicine (Doktor (PhD))
Medizinische Hochschule Hannover, Germany
"Glycosylation of thrombospondin type 1 repeat containing proteins: Importance of C-mannosylation in Toxoplasma gondii." (THESIS/DISSERTATION)
 n/a
2013
Concluded
 Biomedical Sciences (Mestrado)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
"New Leishmania species and their hybrids – implications in pathogeny of infection" (THESIS/DISSERTATION)
 n/a
2011
Concluded
 Bioquímica (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010
Concluded
 Química Aplicada - Ramo de Biotecnologia (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Estudo do comportamento biológico in vitro e in vivo de estirpes e Leishmania infantum" (THESIS/DISSERTATION)
 n/a
Affiliation

Science

Category
Host institution 		Employer
2022/09/01 - 2024/10 Postdoc (Research) Universität Bern, Switzerland
Universität Bern Institut für Zellbiologie, Switzerland
2020/09/01 - 2023/08/31 Postdoc (Research) University of Glasgow, United Kingdom
University of Glasgow Wellcome Centre for Molecular Parasitology, United Kingdom
2018/09/01 - 2020/08/31 Postdoc (Research) Sir William Dunn School of Pathology, United Kingdom
2018/02/01 - 2018/08/30 Postdoc (Research) Medizinische Hochschule Hannover, Germany
2011/06/01 - 2014/06/30 Research Assistant (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Others

Category
Host institution 		Employer
2018 - Current Researcher Global Health and Tropical Medicine, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Projects

Grant

Designation Funders
2021/02/12 - Current Essential calcium transporters in Leishmania: Biochemical characterisation of L. mexicana SERCA and LETM1
unknown
Researcher
University of Glasgow, United Kingdom
 Scottish Universities Life Sciences Alliance
Ongoing
2024/11/01 - 2027/11/30 LeishBlock: Exploring an antileishmanial drug toolbox for blocking pathogen transmission in the sand fly vector
NA
Research Fellow
Univerzita Karlova, Czech Republic

Schweizerisches Tropen- und Public Health-Institut, Switzerland
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
Ongoing
2020/09/01 - 2023/08/31 TransLeish: Fitness phenotyping of Leishmania transporter mutants
MR/V000446/1
Post-doc Fellow
Medical Research Council, United Kingdom
 Medical Research Council
Concluded
2022/10/21 - 2023/07/31 The Leishmania Transportome Atlas - A map to fight Leishmaniasis
NA
Principal investigator
University of Glasgow, United Kingdom
 Biochemical Society
Ongoing
2022/09/01 - 2022/12/31 LINFTAG - Adapting CRISPR/Cas9 protein tagging in Leishmania infantum Portuguese strains
BRF 2022
Principal investigator
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

University of Glasgow, United Kingdom
PARSUK
Ongoing
2021/07 - 2021/08 Defining the localisation of calcium transporter proteins in Leishmania mexicana parasites
PARSUK Xperience
Supervisor
Portuguese Association of Researchers and Students in the UK, United Kingdom
Concluded
2018/09/01 - 2020/08/31 A targeted knockout screen for identification of Leishmania membrane transporters required for infection of macrophages - TransLeishIon
EU project 798736
Post-doc Fellow
Sir William Dunn School of Pathology, University of Oxford, United Kingdom
 EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
Concluded
2014/07/01 - 2018/08/31 Parasite glycobiology and anti-parasitic strategies - GlycoPar
FP7-PEOPLE-2013-ITN
PhD Student Fellow
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
Concluded
2011 - 2014 New Leishmania species and hybrids- risk of introduction and implications to the pathogeny of infection - Leishybrid
PTDC/CVT/112371/2009
Research Fellow
Fundação para a Ciência e a Tecnologia, Portugal
Outputs

Publications

Conference paper
  1. Albuquerque-Wendt, Andreia; S. Cortes; A. Albuquerque-Wendt; J. Canudo; L. Campino. "In vitro biological behavior of Leishmania infantum/L. major hybrid strains from Mediterranean basin, Portugal.". Paper presented in In XI European Multicolloquium of Parasitology, V. Cosma (Ed.), Medimond International Proceedings, Bolonha, 2012.
Conference poster
  1. Albuquerque-Wendt, Andreia; Ricce Espada, Caroline; Gluenz, Eva. "'High-throughput Genetic Screen of the Leishmania mexicana transportome highlights transporter proteins important for parasite fitness in vitro and in vivo.". Paper presented in Membrane proteins workshop & SMALP 2022, 2022.
  2. A. Albuquerque-Wendt (D71C-9907-63EB); C. Hoppe; A. Shcherbakova; F. Buettner; G. Bandini; D. Leon; C. Costello; et al. "Apicomplexan C-mannosyltransferases modify adhesins of the TRAP family.". Paper presented in BSP Spring Meeting 2018, 2018.
  3. A. Albuquerque-Wendt (D71C-9907-63EB); C. Hoppe; A. Shcherbakova; L. Izquierdo; F. Buettner; H. Bakker; F. Routier. "C-mannosylation of Apicomplexan TSR containing adhesins.". Paper presented in TOXO14, 2017.
  4. A. Albuquerque-Wendt (D71C-9907-63EB); L. Cardoso; L. Campino; S. Cortes. "Comparative evaluation of molecular methods to detect Leishmania DNA in dogs". Paper presented in BSP Spring Meeting 2017, 2017.
  5. A. Albuquerque-Wendt (D71C-9907-63EB); C. Hoppe; A. Shcherbakova; L. Izquierdo; F. Buettner; H. Bakker; F. Routier. "C-mannosylation of Toxoplasma gondii Thrombospondin Type 1 Repeats". Paper presented in Glycobiology Gordon Research Conference, 2017.
  6. Albuquerque-Wendt, Andreia. "Glycosylation of Toxoplasma gondii Thrombospondin Type 1 Repeats". Paper presented in GlycoPar symposium & Workshop, 2016.
  7. Albuquerque-Wendt, Andreia. "Targeting C-mannosylation in Apicomplexan parasites". Paper presented in BREATH Summer School, 2015.
  8. A. Albuquerque-Wendt (D71C-9907-63EB); S. Cortes; C. Maia; M. Carvalho; L. AR de Freitas; W. LC dos-Santos; L. Campino. "Insights on immunological and histopathological features of L. infantum/L. major hybrid strains in BALB/c mice infection". Paper presented in BSP Spring Meeting 2014, 2014.
  9. A. Albuquerque-Wendt (D71C-9907-63EB); G. Manjate; L. Campino; S. Cortes. "Evaluation of RAW 264.7 cell line permissiveness to Leishmania parasites.". Paper presented in Microscopy in Research, 2013.
  10. S.Cortes; Albuquerque-Wendt, Andreia; L. Cabral; M.L. Cristiano; L. Campino. "In vitro evaluation of the leishmanicidal effect of selected peroxides". Paper presented in WorldLeish 2013, 2013.
  11. A. Albuquerque-Wendt (D71C-9907-63EB); S. Cortes; L. Cardoso; L. Campino. "Evaluation of different PCR protocols for the detection of Leishmania DNA in the diagnosis of canine leishmaniasis". Paper presented in WorldLeish 2013, 2013.
  12. S. Cortes; J. M. Cristóvão; J. Oliveira; A. Albuquerque-Wendt (D71C-9907-63EB); J. Nina; L. Campino. "Casos importados de leishmaniose cutânea em Portugal". Paper presented in 2º Congresso Nacional de Medicina Tropical, 2013.
  13. A. Albuquerque-Wendt (D71C-9907-63EB); L. Campino; S. Cortes. "Susceptibilidade de estirpes de Leishmania spp. do Velho Mundo à Anfotericina B - Resultados preliminares". Paper presented in 2º Congresso Nacional de Medicina Tropical, 2013.
  14. A. Albuquerque-Wendt (D71C-9907-63EB); L. Campino; S. Cortes. "Estudos fenotípicos de estirpes híbridas de Leishmania sp. Do Velho Mundo". Paper presented in XVI Congresso Português de Parasitologia, 2012.
Journal article
  1. Ricce Espada, Caroline; Quilles Jr., Jose Carlos; Albuquerque-Wendt, Andreia; C. Cruz, Mario; Beneke, Tom; B. Lorenzo, Lucas; Gluenz, Eva; K. Cruz, Angela; R. B. Uliana, Silvia. "Effective Genome Editing in Leishmania (Viannia) braziliensis Stably Expressing Cas9 and T7 RNA Polymerase". Frontiers in Cellular and Infection Microbiology 11 (2021): http://dx.doi.org/10.3389/fcimb.2021.772311.
    10.3389/fcimb.2021.772311
  2. Espada, C.R.; Albuquerque-Wendt, A.; Hornillos, V.; Gluenz, E.; Coelho, A.C.; Uliana, S.R.B.; Ricce Espada, Caroline; et al. "Ros3 (Lem3p/CDC50) Gene Dosage Is Implicated in Miltefosine Susceptibility in Leishmania (Viannia) braziliensis Clinical Isolates and in Leishmania (Leishmania) major". ACS Infectious Diseases 7 4 (2021): 849-858. http://www.scopus.com/inward/record.url?eid=2-s2.0-85103766178&partnerID=MN8TOARS.
    Accepted • 10.1021/acsinfecdis.0c00857
  3. Albuquerque-Wendt, Andreia; Jacot, Damien; Dos Santos Pacheco, Nicolas; Seegers, Carla; Zarnovican, Patricia; Buettner, Falk F. R.; Bakker, Hans; Soldati-Favre, Dominique; Routier, Françoise H.. "C-Mannosylation of Toxoplasma gondii proteins promotes attachment to host cells and parasite virulence". Journal of Biological Chemistry 295 4 (2019): 1066-1076. http://dx.doi.org/10.1074/jbc.ra119.010590.
    10.1074/jbc.ra119.010590
  4. Albuquerque-Wendt, Andreia; Hütte, Hermann J.; Buettner, Falk F. R.; Routier, Françoise H.; Bakker, Hans. "Membrane Topological Model of Glycosyltransferases of the GT-C Superfamily". International Journal of Molecular Sciences 20 19 (2019): 4842. http://dx.doi.org/10.3390/ijms20194842.
    10.3390/ijms20194842
  5. Bandini, G.; Albuquerque-Wendt, A.; Hegermann, J.; Samuelson, J.; Routier, F.H.; Bandini, Giulia; Albuquerque-Wendt, Andreia; et al. "Protein O- And C-Glycosylation pathways in Toxoplasma gondii and Plasmodium falciparum". Parasitology 146 14 (2019): 1755-1766. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061751385&partnerID=MN8TOARS.
    Published • 10.1017/S0031182019000040
  6. Cortes, S.; Albuquerque-Wendt, A.; Maia, C.; Carvalho, M.; Lima, I. A.; de Freitas, L. A. R.; dos-Santos, W. L. C.; et al. "Elucidating in vitro and in vivo phenotypic behaviour of L. infantum/L. major natural hybrids". Parasitology 146 5 (2018): 580-587. http://dx.doi.org/10.1017/s0031182018001993.
    10.1017/s0031182018001993
  7. Hoppe, Carolin M; Albuquerque-Wendt, Andreia; Bandini, Giulia; Leon, Deborah R; Shcherbakova, Aleksandra; Buettner, Falk F R; Izquierdo, Luis; et al. "Apicomplexan C-Mannosyltransferases Modify Thrombospondin Type I-containing Adhesins of the TRAP Family". Glycobiology 28 5 (2018): 333-343. http://dx.doi.org/10.1093/glycob/cwy013.
    10.1093/glycob/cwy013
  8. Albuquerque, Andreia; Campino, Lenea; Cardoso, Luís; Cortes, Sofia. "Evaluation of four molecular methods to detect Leishmania infection in dogs". Parasites & Vectors 10 1 (2017): http://dx.doi.org/10.1186/s13071-017-2002-2.
    10.1186/s13071-017-2002-2
  9. Cortes, Sofia; Albuquerque, Andreia; Cabral, Lília I. L.; Lopes, Liliana; Campino, Lenea; Cristiano, Maria L. S.. "In VitroSusceptibility of Leishmania infantum to Artemisinin Derivatives and Selected Trioxolanes". Antimicrobial Agents and Chemotherapy 59 8 (2015): 5032-5035. http://dx.doi.org/10.1128/aac.00298-15.
    10.1128/aac.00298-15
Preprint
  1. Tom Beneke; Rachel Neish; Carolina M C Catta-Preta; James Smith; Jessica Valli; Ciaran J McCoy; Andreia Albuquerque-Wendt; Jeremy C Mottram; Eva Gluenz. "IFT and BBSome proteins are required for Leishmania mexicana pathogenicity, but flagellar motility is dispensable". 2024. https://doi.org/10.1101/2024.09.13.612850.
    10.1101/2024.09.13.612850
  2. Andreia Albuquerque-Wendt; Ciaran McCoy; Rachel Neish; Ulrich Dobramysl; Tom Beneke; Sally A. Cowley; Kathryn Crouch; et al. "TransLeish: Identification of membrane transporters essential for survival of intracellularLeishmaniaparasites in a systematic gene deletion screen". 2024. https://doi.org/10.1101/2024.06.21.600025.
    10.1101/2024.06.21.600025
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/11 Gliding into a sweet playground of Protozoan genetics Seminar
Unidade de Investigação LAQV e UCIBIO (Caparica, Portugal)
2018/10 L. infantum/ L. major natural hybrids: Insights on in vitro and in vivo phenotypic behavior Leishmaniasis 2018: 1st International congress on leishmaniasis
Bioscope, FCT-UNL (Caparica, Portugal)
2018/10 A Trypanosomatidae-Apicomplexan playground: A sweet and bumpy rollercoaster GHTM Sessions
GHTM - IHMT-UNL (Lisbon, Portugal)
2018/04 Apicomplexan C-mannosyltransferases modify adhesins of the TRAP family. BSP Spring Meeting 2018
British Society of Parasitology (Aberystwyth, United Kingdom)
2017/03 C-mannosylation of Toxoplasma gondii Thrombospondin Type 1 Repeats Glycobiology Gordon Research Seminar
(Ventura, United States)
2016 Glycosylation of Toxoplasma gondii Thrombospondin Type 1 Repeats GlycoPar symposium & Workshop
Liverpool School of Tropical Medicine (Liverpool , United Kingdom)
2013 Leishmania hybrids and their implication in pathogeny of infection 8th CCMAR seminar series
CCMAR, Universidade do Algarve (Algarve, Portugal)
2010 Estudo do comportamento biológico de estirpes dermotrópicas e viscerotrópicas de Leishmania infantum - Resultados Preliminares XIV Congresso Português de Parasitologia
Sociedade Portuguesa de Parasitologia (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2014 - 2014 Efeito leishmanicida de endoperóxidos sintéticos
Co-supervisor
2014 - 2014 Pesquisa de DNA de diferentes espécies de Leishmania em amostras biológicas
Co-supervisor
2013 - 2013 Avaliação da permissividade celular à infeção por estirpes de Leishmania spp.
Co-supervisor
2013 - 2013 Suscetibilidade de diferentes estirpes de Leishmania ao fármaco Anfotericina B
Co-supervisor
2013 - 2013 Impacto das culturas axénicas contínuas em Leishmania infantum.
Co-supervisor
2013 - 2013 Técnicas laboratoriais aplicadas ao diagnóstico e investigação em leishmaniose
Co-supervisor

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/03/16 - 2024/03/16 MCAA Annual Conference and General Assembly Parallel session: Science Communication: Success Stories & Future Directions (Milan, Italy) (2024/03/16 - 2024/03/16)
Seminar (President of the Organising Committee)
 Marie Curie Alumni Association, United Kingdom

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022 - Current CU Molecular Parasitology (PT: Parasitologia Molecular), MSc Biomedical Sciences, Edição génica em tripanossomatídeos, IHMT-UNL (PT), (2h00, presential seminar) Biomedical Sciences (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2021 - Current CU Investigation in Leishmaniases and applied methodologies (PT: Investigação em Leishmanioses e metodologias aplicadas), MSc Medical Parasitology, Edição génica em tripanossomatídeos, IHMT-UNL (PT), (2h30, presential seminar) Medical Parasitology (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2021 - Current CU Parasitology topics (PT: Tópicos em Parasitologia), MSc Pharmaceutical Sciences, Edição génica em tripanossomatídeos, Universidade Federal do Rio Grande do Norte (BZ), (1h30, on-line seminar) Pharmaceutical Sciences (Master) Universidade Federal do Rio Grande do Norte, Brazil
2020 - Current Curricular Unit (CU) Cell Cultures: pratical applications, MSc Biomedical Sciences, Utilização de linhas celulares para o cultivo de protozoários intracelulares obrigatórios: Toxoplasma e Leishmania, IHMT-UNL (PT), (1h, on-line seminar) Biomedical Sciences (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2013 - 2014 CU Investigation in Leishmaniases and applied methodologies, MSc Medical Parasitology (preparation and demonstration of practical classes on the topic of Leishmania parasite genotyping and leishmaniases serological techniques), IHMT-UNL (PT) Medical Parasitology (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Distinctions

Award

2022 Best Poster Presentation
European SMALP, Birmingham University, United Kingdom
2022 Best Oral Presentation
Wellcome Centre for Integrative Parasitology, UofG (WCIP/ISAB retreat), United Kingdom
2022 Best Research Pitch
PARSUK, United Kingdom
2022 Biology of Vector-borne Diseases Course - Course Waiver
University of Idaho, United States
2020 Excellent Shotgun Communication Prize
Associação Científica Proteomass, Portugal
2019 C.C. Wang Prize in Molecular Parasitology
Marine Biological Laboratory, United States
2019 Best poster - post-doc symposium
Sir William Dunn School of Pathology, University of Oxford, United Kingdom
2019 Biology of Parasitism - Modern Approaches - Course Waiver
Burroughs Welcome Fund - Marine Biological Laboratory, Woods Hole, United States

Other distinction

2022 Travel Award
Biochemical Society, United Kingdom
2022 Travel Award
Microbiology Society, United Kingdom
2022 Travel Award
British Society for Cell Biology, United Kingdom
2022 Travel Award
PARSUK, United Kingdom
2020 Travel Award
University of Oxford, United Kingdom
2020 Travel Award
Biochemical Society, United Kingdom
2020 Travel Award
University of Oxford, United Kingdom
2019 Travel Award
University of Oxford, United Kingdom
2019 Travel Award
Marie Curie Alumni Association, United Kingdom
2017 Travel Award
British Society for Parasitology, United Kingdom
2017 Travel Award
Marie Curie Alumni Association, United Kingdom