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João David Panão da Costa. Completed the Mestrado integrado in Pharmaceutical Sciences in 2017/09/22 by Universidade de Coimbra Faculdade de Farmácia. Attends the Doutoramento in PhD in Pharmaceutical Sciences (Pharmaceutical Biotechnology) by Universidade de Coimbra Faculdade de Farmácia since 2018/07/03. Is PhD student working on the project: "Development of a therapeutic hepatitis B vaccine: designing a particulate-based multicomponent prototype for immunomodulation" in Fundação para a Ciência e a Tecnologia and Researcher in Universidade de Coimbra. Published 7 articles in journals. Has 1 section(s) of books. Participated in 1 event(s). Co-supervised 2 MSc dissertation(s). Has received 4 awards and/or honors. Participates and/or participated as Master Student Fellow in 1 project(s) and Researcher in 3 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Medical Biotechnology with emphasis on Health-Related Biotechnology, Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Immunology, Medical and Health Sciences with emphasis on Clinical Medicine with emphasis on Gastroenterology and hepatology, Medical and Health Sciences with emphasis on Medical Biotechnology with emphasis on Biomaterials, Natural sciences with emphasis on Biological Sciences with emphasis on Virology and Medical and Health Sciences with emphasis on Health Sciences with emphasis on Infectious Diseases. In their professional activities interacted with 53 collaborator(s) co-authorship of scientific papers.
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Identification

Personal identification

Full name
João David Panão da Costa

Citation names

  • Panão Costa, João
  • Costa, João
  • Panão-Costa, João

Author identifiers

Ciência ID
D812-B92E-4FCD
ORCID iD
0000-0002-2414-8945

Email addresses

  • jpanao94@gmail.com (Professional)
  • uc45732@uc.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Clinical Medicine - Gastroenterology and hepatology
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Natural sciences - Biological Sciences - Virology
  • Medical and Health Sciences - Health Sciences - Infectious Diseases
  • Medical and Health Sciences - Clinical Medicine - Oncology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2018/01/01 - 2024/11/15
Concluded
 PhD in Pharmaceutical Sciences (Pharmaceutical Biotechnology) (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"DEVELOPMENT OF A THERAPEUTIC HEPATITIS B VACCINE: DESIGNING A PARTICULATE-BASED MULTICOMPONENT PROTOTYPE FOR IMMUNOMODULATION" (THESIS/DISSERTATION)
2023/03/06 - 2023/03/08
Attended
 Flow Cytometry and Cell Sorting - From Basic Concepts to Artificial Intelligence applied to Data Analysis (Outros)
CNC.IBILI, Portugal
2019/07/15
Concluded
 Course on Laboratory Animal Science, Felasa Category B (Outros)
Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2019/03/28
Attended
 Training Course on Adjuvants and Vaccine Formulation (Outros)
Vaccine Formulation Institute, Switzerland
2019/01/18
Attended
 Course on Biostatistics (Outros)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/08/20 - 2018/06/02
Concluded
 Pharmaceutical Biotechnology (Curso de mestrado (conclusão do curso de especialização))
Universidade de Coimbra Faculdade de Farmácia, Portugal
 17
2012/09/10 - 2017/09/22
Concluded
 Pharmaceutical Sciences (Mestrado integrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Internship Reports and Monograph titled "Chitosan-based Nanoparticles for Gene Delivery"" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2023/07/19 - Current Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
(...)
2018/04/16 - 2018/12/31 Researcher (Research) CNC.IBILI, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/09/25 - 2018/04/13 Research Trainee (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/11/14 - 2017/09/22 Research Trainee (Research) Universidade de Coimbra Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2019/01/01 - 2024/11/15 PhD student Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
(...)
Projects

Grant

Designation Funders
2021/10/10 - 2022/12/31 Vacina Intranasal genética contra o COVID: estudos de imunização em murganhos
13824
Researcher
Gilead Sciences Lda
2018 - 2021 Hepatitis B therapeutic vaccine: Production of glucan-based particles towards selective delivery hepatitis B antigens to immune cells to induce antiviral activity - POCI-01-0145-FEDER-030331
POCI-01-0145-FEDER-030331
Researcher
2018/04 - 2019/12 Polymeric NanoBioMaterials for drug delivery: developing and implementation of safe-by-design concept enabling safe healthcare solutions - ProSafe JTC/0001/2016
ProSafe JTC/0001/2016
Master Student Fellow
Concluded

Contract

Designation Funders
2023/07/19 - Current CInTech: Technological Hub for Innovation, Translation and Industrialization of Complex Injectable Drugs
7131
Researcher
CNC.IBILI, Portugal

Bluepharma, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Ongoing
Outputs

Publications

Book chapter
  1. Colaço, Mariana; Panão Costa, João; Borges, Olga. "Glucan Particles: Choosing the Appropriate Size to Use as a Vaccine Adjuvant". In Methods in Molecular Biology, 269-280. Springer US, 2021.
    10.1007/978-1-0716-1892-9_13
Conference poster
  1. Batista, A.; Nikitin, T.; Voronovska, Anastasiya; Cardoso, H.; Panão Costa, João; Amaral, A. T.; Moreira, J. N.. "Confocal Raman Microscopy for Exploring Lipid-Nanoparticle Intracellular Trafficking in Cancer Cells". Paper presented in Applied Biophysics Forum in Drug Delivery, 2024.
  2. Batista, Ana; Nikitin, T.; Cardoso, H.; Voronoska, A.; Panão Costa, João; Pedroso, S.; Amaral, A. T.; Moreira, J. N.. Corresponding author: Batista, Ana. "Towards tracing lipid-nanoparticle intracellular trafficking in cancer cells by confocal Raman microscopy". Paper presented in 6th ASPIC International Congress, 2024.
  3. Panão Costa, João; Colaço, M.; Félix, P.; Melo, A. A.; Lebre, F.; Cruz, M. T.; Alfaro-Moreno, E.; Moreira, J. N.; Borges, O.. Corresponding author: Panão Costa, João. "ß-glucan polymeric microparticles: innovating cancer immunotherapy through targeted antigen delivery". Paper presented in 6th ASPIC International Congress, 2024.
  4. Félix, Paulo; Panão Costa, João; Colaço, Mariana; Borges, Olga. "Toll-like Receptor Ligands as Oral Vaccine Adjuvants: Immunomodulatory Effects against SARS-CoV-2". Paper presented in X Congresso Iberoamericano de Ciências Farmacêuticas. Coimbra, Portugal, 2023.
  5. A. Melo, Alexandra; Colaço, Mariana; Panão Costa, João; Borges, Olga. "Effect of the Roots of Withania somnifera Encapsulated Into ß-Glucan Particles". Paper presented in X Congresso Iberoamericano de Ciências Farmacêuticas. Coimbra, Portugal, 2023.
  6. Félix, Paulo; Panão Costa, João; Colaço, Mariana; Borges, Olga. "The immunomodulatory potential of a dual TLR agonist strategy as an oral vaccine adjuvant for SARS-CoV-2". Paper presented in iMed Conference 15.0 Lisbon 2023, 2023.
  7. FÉLIX, PAULO; Panão Costa, João; Colaço, Mariana; Borges, Olga. "The immunomodulatory potential of a dual TLR agonist strategy as a vaccine adjuvant". Paper presented in IV Young Scientist Meeting of the Spanish Portuguese Local Chapter-Controlled Release Society (SPLC-CRS), 2023.
  8. Colaço, Mariana; Panão Costa, João; Jesus, Sandra; Borges, Olga. "The contamination of nanoparticles with endotoxins does not always influence immunotoxicity studies: chitosan as a case study". Paper presented in IV Young Scientist Meeting of the Spanish Portuguese Local Chapter-Controlled Release Society (SPLC-CRS), 2023.
  9. Panão Costa, João; Colaço, Mariana; Jesus, Sandra; Borges, Olga. Corresponding author: Panão Costa, João. "Immunotoxicological properties of yeast-derived glucan particles". Paper presented in XIV Spanish-Portuguese Conference on Controlled Drug Delivery, Tenerife, 2022, 2022.
  10. Jesus, Sandra; Duarte, Henrique; Panão Costa, João; Colaço, Mariana; Borges, Olga. "Inulin-PCL nanoparticles as an adjuvant delivery system for highly purified recombinant antigens". Paper presented in XIV Spanish-Portuguese Conference on Controlled Drug Delivery, Tenerife, 2022, 2022.
  11. Colaço, Mariana; Panão Costa, João; Roquito, Tiago; Jesus, Sandra; Borges, Olga. "Evaluation of the hemocompatibility and immunotoxicity properties of two sized curcumin-loaded glucan nanoparticles". Paper presented in XIV Spanish-Portuguese Conference on Controlled Drug Delivery, Tenerife, 2022, 2022.
  12. Jesus, Sandra; Colaço, Mariana; Panão Costa, João; Borges, Olga. "Chronic Hepatitis B (CHB) vaccine: Shedding light on the immunotoxicity of chitosan as a nano-delivery system". Paper presented in CIBB Metting, Coimbra, Portugal, 2019.
  13. Jesus, Sandra; Da Silva, Jessica; Bernardi, Natália; Panão Costa, João; Borges, Olga. "Polyester nanoparticles: Relationship between structure and activity". Paper presented in 46th Controlled Release Society Annual Meeting & Exposition, Valencia, Spain, 2019.
  14. Jesus, Sandra; Marques, Ana Patrícia; Duarte, Alana; Soares, Edna; Colaço, Mariana; Panão Costa, João; Som, Claudia; et al. "Safe-by-design of chitosan nanoparticles: the role of immunotoxicological properties". Paper presented in SPI XLV Annual Meeting, Coimbra, Portugal, 2019.
  15. Jesus, Sandra; Da Silva, Jéssica; Bernardi, Natália; Panão Costa, João; Borges, Olga. "Polyester Nanoparticle Immunotoxicological Profile". Paper presented in SPI XLV Annual Meeting, Coimbra, Portugal, 2019.
  16. Raquel Araújo; Mariana Colaço; Panão Costa, João; Natalia Bernardi; Sandra Jesus; Olga Borges. "Nanocapsules containing sucupira oil: cytotoxicity and hemolysis evaluation". Paper presented in 22nd International Symposium on Microencapsulation, 2019.
  17. Duarte, Alana; Marques, Ana Patrícia; Jesus, Sandra; Panão Costa, João; Soares, Edna; Colaço, Mariana; Borges, Olga. "Assessment of immunotoxicological features of chitosan nanoparticles.". Paper presented in 2nd SPLC-CRS Young Scientists Meeting, Santiago de Compostela, Spain, 2019.
  18. Panão Costa, João; Jesus, Sandra; Soares, Edna; Borges, Olga. "Chitosan-based nanoparticles for gene delivery". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, Coimbra, Portugal, 2018.
Journal article
  1. Roquito, Tiago; Colaço, Mariana; Panão Costa, João; Borges, Olga. "Curcumin-encapsulated glucan nanoparticles as an oxidative stress modulator against human hepatic cancer cells". Colloids and Surfaces B: Biointerfaces 245 (2025): 114326. http://dx.doi.org/10.1016/j.colsurfb.2024.114326.
    Published • 10.1016/j.colsurfb.2024.114326
  2. Panão Costa, João; de Carvalho, Armando; Paiva, Artur; Borges, Olga. "Insights into Immune Exhaustion in Chronic Hepatitis B: A Review of Checkpoint Receptor Expression". Pharmaceuticals 17 7 (2024): 964. http://dx.doi.org/10.3390/ph17070964.
    10.3390/ph17070964
  3. Panão Costa, João; Jesus, Sandra; Colaço, Mariana; Lebre, Filipa; Mateus, Daniela; Sebastião, Ana Isabel; Cruz, Maria Teresa; Alfaro-Moreno, Ernesto; Borges, Olga. "Exploring the immunomodulatory properties of glucan particles in human primary cells". International Journal of Pharmaceutics 655 123996 (2024): https://www.sciencedirect.com/science/article/pii/S0378517324002308?via%3Dihub.
    Open access • Published
  4. Panão Costa, João; Jesus, Sandra; Colaço, Mariana; Duarte, Alana; Soares, Edna; Borges, Olga. Corresponding author: Borges, Olga. "Endotoxin contamination of nanoparticle formulations: A concern in vaccine adjuvant mechanistic studies.". Vaccine 41 23 (2023): 3481-3485.
    Published • https://doi.org/10.1016/j.vaccine.2023.04.063
  5. Colaço, Mariana; Roquito, Tiago; Panão Costa, João; Cruz, Maria Teresa; Borges, Olga. Corresponding author: Borges, Olga. "The Effect of Curcumin-Loaded Glucan Nanoparticles on Immune Cells: Size as a Critical Quality Attribute". Pharmaceutics 15 2 (2023): 623. http://dx.doi.org/10.3390/pharmaceutics15020623.
    Published • 10.3390/pharmaceutics15020623
  6. Jesus, Sandra; Bernardi, Natalia; da Silva, Jessica; Colaço, Mariana; Panão Costa, João; Fonte, Pedro; Borges, Olga. "Unravelling the Immunotoxicity of Polycaprolactone Nanoparticles—Effects of Polymer Molecular Weight, Hydrolysis, and Blends". Chemical Research in Toxicology 33 11 (2020): 2819-2833.
    Published
  7. Jesus, Sandra; Marques, Ana Patrícia; Duarte, Alana; Soares, Edna; Costa, João Panão; Colaço, Mariana; Schmutz, Mélanie; et al. "Chitosan Nanoparticles: Shedding Light on Immunotoxicity and Hemocompatibility". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.00100.
    Open access • Published • 10.3389/fbioe.2020.00100
  8. Panão Costa, João; Carvalho, Sofia; Jesus, Sandra; Soares, Edna; Marques, Ana Patrícia; Borges, Olga. "Optimization of Chitosan-a-casein Nanoparticles for Improved Gene Delivery: Characterization, Stability, and Transfection Efficiency". AAPS PharmSciTech 20 3 (2019): http://dx.doi.org/10.1208/s12249-019-1342-y.
    Published • 10.1208/s12249-019-1342-y
  9. Jesus, Sandra; Soares, Edna; Costa, João; Borchard, Gerrit; Borges, Olga. "Immune response elicited by an intranasally delivered HBsAg low-dose adsorbed to poly-e-caprolactone based nanoparticles". International Journal of Pharmaceutics 504 1-2 (2016): 59-69. http://dx.doi.org/10.1016/j.ijpharm.2016.03.013.
    Published • 10.1016/j.ijpharm.2016.03.013
Thesis / Dissertation
  1. Panão Costa, João. "Chitosan-based nanoparticles for gene delivery". Master, Universidade de Coimbra Faculdade de Farmácia, 2017.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/02/14 Hepatic-Targeted Dual Oral Vaccine Formulation for Chronic Hepatitis B: Amplifying Immune Efficacy with Glucan Particles. XV Spanish Portuguese Conference on Controlled Drug Delivery
(Lisbon, Portugal)
2023/02/06 ß-glucan and TLR 7/8 agonist combination as a new adjuvant against chronic hepatitis B 4th SPLC-CRS Young Scientists Meeting
Spanish Portuguese Local Chapter-Controlled Release Society (SPLC-CRS) (Porto, Portugal)
2022/02/10 Immunotoxicological properties of yeast-derived glucan particles SPF Meeting 2022
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2021/07/27 The immunostimulatory ability of glucan particles on human DCs: a promising platform for the design of a chronic hepatitis B vaccine Controlled Release Society 2021 Virtual Annual Meeting
Controlled Release Society (CRS)
2019/02/07 Endotoxin-free chitosan does not stimulate human PBMCs proinflammatory cytokine secretion SPF Meeting 2019
Sociedade Portuguesa de Farmacologia (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/09/01 - Current Lactobionic acid-modified polylactic acid nanoparticles as a vaccine adjuvant delivery system
Co-supervisor
2022/09/01 - 2023/10/16 The immunomodulatory potential of a dual TLR agonist strategy as a vaccine adjuvant
Co-supervisor
Universidade de Coimbra Faculdade de Farmácia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/02/27 - 2019/02/27 Análise de partículas do Nanómetro ao Milímetro
Workshop
 Análise de partículas do Nanómetro ao Milímetro
Paralab SA, Portugal

Association member

Society Organization name Role
2024/01/01 - Current Sociedade Portuguesa de Imunologia (SPI)
2023/01/01 - Current Associação Portuguesa de Investigação em Cancro (ASPIC)
2023/01/01 - Current European Association for Cancer Research (EACR)
2022/01/01 - Current Spanish Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS)
2021/05/01 - 2021/12/31 Controlled Release Society (CRS)
2019/03/11 - 2020/03/10 Sociedade Portuguesa de Ciências em Animais de Laboratório (SPCAL)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/04/09 - Current Lecture on: Glucan-based particle adjuvants as a strategy for an oral vaccine Nanoparticles & Immune System (Doutoramento) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Distinctions

Award

2021 Bolsa de Investigação APEF/MSD 2021
Associação Portuguesa para o Estudo do Fígado, Portugal
2019 TRANSVAC2/ ENOVA Adjuvant and Vaccine Formulation Training School Studentship
European Network on Vaccine Adjuvants (ENOVA), United Kingdom
2018 FCT individual PhD studentship (SFRH/BD/139142/2018)
Fundação para a Ciência e a Tecnologia, Portugal

Title

2019 Accreditation as Investigator for scientific experimentation involving animals (FELASA category B, certified by DGAV, Portugal)
Direcção-Geral de Alimentação e Veterinária, Portugal, Portugal