Mariana Antunes Castelôa (D81A-1E0E-3E72)

Curriculum Vitae

Mariana Antunes Castelôa

Mariana Castelôa completed her BSc in Biochemistry in 2019 and her MSc in Applications in Biotechnology and Synthetic Biology in 2021, at FCUP - Faculty of Sciences of the University of Porto. During her Master's dissertation, she worked at FFUP - Faculty of Pharmacy of the University of Porto, evaluating the pharmacological effects of bioactive compounds, where she was also a co-supervisor of a BSc international student. In 2022, she worked with a Master Research Grant at CIQUP - Research Center in Chemistry of the University of Porto, integrated with the FCT-funded project NOXIOUS (EXPL/BIABQM/0492/2021), which aims to develop targeted covalent inhibitors to unravel NOX2 crystal structure, counting with the collaboration of Prof. Andrea Mattevi (UniPV, Italy). Currently, she is enrolled in the Doctoral Program in Chemistry at FCUP, developing her PhD thesis entitled "Bona fide NOX2 inhibitors: a new therapeutic solution for neurodegenerative diseases". In her academic curriculum, she has 3 oral communications with abstract publication, 6 posters, and is the first author of 1 article published in a peer-review international journal.

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Identification

Personal identification

Full name: Mariana Antunes Castelôa

Citation names

Castelôa, Mariana
Castelôa, M.

Author identifiers

Ciência ID: D81A-1E0E-3E72
ORCID iD: 0000-0002-0913-3219

Websites

https://drugdiscoveryup.pt/ (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Biochemistry
Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2022/10 - 2026 Ongoing	Química (Doutoramento) Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Faculdade de Engenharia, Portugal "Bona fide NOX2 inhibitors: a new therapeutic solution for neurodegenerative diseases" (THESIS/DISSERTATION)
2022/04 - 2022/09 Concluded	Curso de Estudos Avançados em Projeto Científico e Tecnológico (Outros) Universidade do Porto Faculdade de Ciências, Portugal	19
2019 - 2021 Concluded	Aplicações em Biotecnologia e Biologia Sintética (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal "In vitro effects of mitochondria-targeted antioxidants in ovarian and endometrial cancer " (THESIS/DISSERTATION)	18
2016 - 2019 Concluded	Bioquímica (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "The importance of fertility preservation in cancer patients treated with cyclophosphamide" (THESIS/DISSERTATION)	15

Affiliation

Others

	Category Host institution	Employer
2022/10 - Current	PhD Student (FCT Grant - 2022.13356.BD)	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal
2022/04 - 2022/09	Master Research Fellow (NOXIous Project - EXPL/BIA-BQM/0492/2021)	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal

Projects

Grant

	Designation	Funders
2022/05 - 2023/07	NOXIous - Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure EXPL/BIA-BQM/0492/2021 PhD Student Fellow Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Centro de Investigação em Química, Portugal Università degli Studi di Pavia Dipartimento di Biologia e Biotecnologie L. Spallanzani, Italy	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Conference abstract	Castelôa, Mariana; Reis, Joana; Lima, Carla; Massari, Marta; Marchese, Sara; Basile, Lorenzo; Borges, Fernanda; et al. "Insights into the Development of Isoform-Selective, Non-Interfering NOX Inhibitors". Paper presented in MedChem 2024 - XIII Meeting of the Paul Ehrlich Euro-PhD Network & COST ACTION, Rome, 2024. Published Lima, Inês; Castelôa, Mariana; Chavarria, Daniel; Conde, Carlos; Pombinho, António; Borges, Fernanda. "High throughput screening of heterocyclic compounds to identify new spindle assembly checkpoint inhibitors". Paper presented in 17th University of Porto Young Research Meeting (IJUP), Porto, 2024. Published Castelôa, Mariana; Lima, Carla; Benfeito, Sofia; Aguiar, Brandon; Soares, Pedro; Borges, Fernanda; Chavarria, Daniel. "Fine-tuning the reactivity and drug-like profile of potential covalent NOX2 inhibitors". Paper presented in MedChem 2023 - XII Meeting of the Paul Ehrlich Euro PhD Network, Thessaloniki, 2023. Published Castelôa, Mariana; Soares, Pedro; Benfeito, Sofia; Lima, Carla; Borges, Fernanda; Chavarria, Daniel. "Tailoring VAS2870 scaffold to develop new covalent NOX2 inhibitors". Paper presented in XXVI Galician-Portuguese International Conference on Chemistry, Santiago de Compostela, 2022. Published Castelôa, Mariana; Moreira-Pinto, Beatriz; Benfeito, Sofia; Borges, Fernanda; Fonseca, Bruno; Rebelo, Irene. "Evaluation of the effects of a TPP-based mitocan and two derivatives in ovarian and endometrial cancer cell lines". Paper presented in 14th University of Porto Young Research Meeting (IJUP), Porto, 2021. Published Castelôa, Mariana; Moreira-Pinto, Beatriz; Benfeito, Sofia; Borges, Fernanda; Fonseca, Bruno; Rebelo, Irene. "The effects of a TPP-based compound and two derivatives in ovarian and endometrial cancer cells". Paper presented in 1st One-Day Meeting on Biotechnology and Synthetic Biology, Porto, 2021. Published Magalhães, Ana; Castelôa, Mariana; Moreira-Pinto, Beatriz; Fonseca, Bruno; Rebelo, Irene. "In vitro study of the granulosa cells response to activated THP-1 derived macrophages". Paper presented in 13th University of Porto Young Research Meeting (IJUP), Porto, 2020. Published Magalhães, Ana; Moreira-Pinto, Beatriz; Castelôa, Mariana; Fonseca, Bruno; Rebelo, Irene. "Activated macrophages induce inflammatory COX-2 expression in human ovarian granulosa cells". Paper presented in 15th Edition of YES (Young European Scientist) Meeting, Porto, 2020. Published Castelôa, Mariana; Moreira-Pinto, Beatriz; Benfeito, Sofia; Borges, Fernanda; Fonseca, Bruno; Rebelo, Irene. "In vitro study of the effects of a TPP-based mitocan and two derivatives in type 1 and type 2 endometrial cancer cell lines". Paper presented in University Olympiad in Biochemistry COVID-19 Special Edition, Coimbra, 2020. Published
Conference poster	Castelôa, Mariana; Reis, Joana; Lima, Carla; Massari, Marta; Marchese, Sara; Basile, Lorenzo; Borges, Fernanda; et al. "Recent Advances in the Discovery of Isoform-Selective NOX Inhibitors". Paper presented in Encontro Ciência 2024, 2024. Castelôa, Mariana; Reis, Joana; Lima, Carla; Massari, Marta; Marchese, Sara; Basile, Lorenzo; Borges, Fernanda; et al. "Insights into the Development of Isoform-Selective, Non-Interfering NOX Inhibitors". Paper presented in MedChem 2024 - XIII Meeting of the Paul Ehrlich Euro-PhD Network & COST ACTION, 2024. Lima, Inês; Castelôa, Mariana; Chavarria, Daniel; Conde, Carlos; Pombinho, António; Borges, Fernanda. "High throughput screening of heterocyclic compounds to identify new spindle assembly checkpoint inhibitors". Paper presented in 17th University of Porto Young Research Meeting (IJUP), 2024. Castelôa, Mariana; Lima, Carla; Benfeito, Sofia; Aguiar, Brandon; Soares, Pedro; Borges, Fernanda; Chavarria, Daniel. "Fine-tuning the reactivity and drug-like profile of potential covalent NOX2 inhibitors". Paper presented in MedChem 2023 - XII Meeting of the Paul Ehrlich Euro PhD Network, 2023. Castelôa, Mariana; Soares, Pedro; Benfeito, Sofia; Lima, Carla; Borges, Fernanda; Chavarria, Daniel. "Tailoring VAS2870 scaffold to develop new covalent NOX2 inhibitors". Paper presented in XXVI Galician-Portuguese International Conference on Chemistry, 2022. Castelôa, Mariana; Moreira-Pinto, Beatriz; Benfeito, Sofia; Borges, Fernanda; Fonseca, Bruno M.; Rebelo, Irene. "In vitro study of the effects of a TPP-based mitocan and two derivatives in type 1 and type 2 endometrial cancer cell lines". Paper presented in University Olympiad in Biochemistry COVID-19 Special Edition, 2021. Magalhães, Ana; Moreira-Pinto, Beatriz; Castelôa, Mariana; Fonseca, Bruno M.; Rebelo, Irene. "Activated macrophages induce inflammatory COX-2 expression in human ovarian granulosa cells". Paper presented in 15th Edition of YES (Young European Scientist) Meeting, 2020.
Journal article	Castelôa, M.; Moreira-Pinto, B.; Benfeito, S.; Borges, F.; Fonseca, B. M.; Rebelo, I.. "In Vitro Effects of Mitochondria-Targeted Antioxidants in a Small-Cell Carcinoma of the Ovary of Hypercalcemic Type and in Type 1 and Type 2 Endometrial Cancer". Biomedicines 10 4 (2022): Open access • Published • 10.3390/biomedicines10040800
Thesis / Dissertation	Castelôa, Mariana. "In vitro effects of mitochondria-targeted antioxidants in ovarian and endometrial cancer". Master, Universidade do Porto Faculdade de Ciências, 2021. https://hdl.handle.net/10216/137988. Castelôa, Mariana. "The importance of fertility preservation in cancer patients treated with cyclophosphamide". Degree, Universidade do Porto Faculdade de Ciências, 2019.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2021/05	Evaluation of the effects of a TPP-based mitocan and two derivatives in ovarian and endometrial cancer cell lines	14th University of Porto Young Research Meeting (IJUP) Universidade do Porto (Porto, Portugal)
2021/04	The effects of a TPP-based compound and two derivatives in ovarian and endometrial cancer cells	1st One-Day Meeting on Biotechnology and Synthetic Biology Universidade do Porto Faculdade de Ciências (Portugal)
2020/02	In vitro study of the granulosa cells response to activated THP-1 derived macrophages	13th University of Porto Young Research Meeting (IJUP) Universidade do Porto (Porto, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2021/05 - 2021/07	The inflammatory microenvironment within the ovary and female infertility: effects on granulosa cells function Co-supervisor of Symeon Gerasimou	BSc Hons in Immunology & Microbiology (Degree) University of Strathclyde Institute of Pharmacy & Biomedical Sciences, United Kingdom Universidade do Porto Faculdade de Farmácia, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2023/06/26 - 2023/07/12	Co-organizer/Trainer of the international course "Drug Discovery 2030: A Roadmap for a New Decade". This course aimed to improve, via virtual classes and a week of intensive training, the participants' skills in Medicinal Chemistry and Chemistry Biology. This course was funded with support from the European Commission and implemented within the framework of Blended Intensive Programmes (BIPs), a new format of Erasmus+ mobility. https://drugdiscovery2030.pt/ (2023/06/26 - 2023/07/12) Other	Erasmus Plus, Belgium Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Centro de Investigação em Química, Portugal Università degli Studi di Cagliari, Italy Università degli Studi di Pisa, Italy Universiteit Gent Faculteit Farmaceutische Wetenschappen, Belgium
2023/04/20 - 2023/04/23	2023 University of Porto Showcase (MostraUP) (2023/04/20 - 2023/04/23) Exhibition (Co-organisor)	Universidade do Porto, Portugal
2023/03/31 - 2023/04/03	IX National Encounter of Chemistry Students (2023/03/31 - 2023/04/03) Meeting (Member of the Organising Committee)	Universidade do Porto Faculdade de Ciências, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2024/06/17 - 2024/06/19	MedChem 2024 - XIII Meeting of the Paul Ehrlich Euro PhD Network Conference	Università degli Studi di Roma La Sapienza Dipartimento di Chimica e Tecnologia del Farmaco, Italy
2023/07/16 - 2023/07/18	MedChem 2023 - XII Meeting of the Paul Ehrlich Euro PhD Network Conference	Aristoteleio Panepistemio Thessalonikes Tmema Pharmakeutikes, Greece
2022/11/16 - 2022/11/18	XXVI Galician-Portuguese International Conference on Chemistry Conference	Universidade de Santiago de Compostela Facultade de Química, Spain
2021/05/05 - 2021/05/07	14th University of Porto Young Research Meeting (IJUP) Meeting	Universidade do Porto, Portugal
2021/04/23 - 2021/04/23	1st One-Day Meeting on Biotechnology and Synthetic Biology Meeting	Universidade do Porto Faculdade de Ciências, Portugal
2021/03/06 - 2021/03/06	University Olympiad in Biochemistry COVID-19 Special Edition Meeting	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/03/14 - 2019/03/17	VII AEICBAS Biomedical Congress Congress	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/03/23 - 2018/03/26	XI National Meeting of Biochemistry Students Meeting	Universidade do Porto Faculdade de Ciências, Portugal